43,951 results match your criteria Hand Malignant Tumors


Lipoma in the pronator quadratus: A case report.

Medicine (Baltimore) 2020 May;99(21):e20248

Hand Surgery, the Second Hospital of Jilin University, No. 218, Lane Ziqiang, Nanguan District, Changchun City, Jilin.

Rationale: Lipomas are common benign tumors, constituting 16% of soft tissue mesenchymal tumors. They usually occur under the skin or in the large muscles of the thigh, shoulder, or upper arm. There are few reported cases of lipomas located in the forearm and hand muscles, accounting for less than 1% of all lipomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000020248DOI Listing

Risk Assessment and Considerations for Proper Management of Elderly Men with Advanced Prostate Cancer: A Systematic Review.

Eur Urol Oncol 2020 May 26. Epub 2020 May 26.

Northwestern University, Chicago, IL, USA. Electronic address:

Context: Treatment decisions for elderly men with prostate cancer are complicated by the intersection of competing risks of cancer, potential complications of treatment, and individual patients' comorbidities.

Objective: To perform a systematic review of data guiding the assessment of elderly prostate cancer patients that addresses the risk from cancer and treatment, and to discuss a patient-centered approach to incorporating these factors into decision making.

Evidence Acquisition: Evidence was gathered via a systematic review of the current literature. Read More

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http://dx.doi.org/10.1016/j.euo.2020.03.006DOI Listing

Risk factors of impairment of shoulder function after axillary dissection for breast cancer.

Support Care Cancer 2020 May 28. Epub 2020 May 28.

Department of Rehabilitation Medicine, National Hospital Organization Shikoku Cancer Center, Ko-160, Minamiumemoto-cho, Matsuyama City, 7910280, Japan.

Objectives: Postoperative shoulder joint dysfunction has been observed at a certain rate after breast cancer surgery with axillary lymph node dissection. The purposes of this study were to verify the feasibility and effects of home-based exercise using a DVD and clarify the target of intensive intervention with physiotherapy by identifying the factors that cause postoperative shoulder dysfunction.

Methods: The study comprised 237 female patients who underwent breast cancer surgery with axillary lymph node dissection, whose data were acquired until 3 months postoperatively. Read More

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http://dx.doi.org/10.1007/s00520-020-05533-7DOI Listing

Efficacy and safety of camrelizumab combined with apatinib in advanced triple-negative breast cancer: an open-label phase II trial.

J Immunother Cancer 2020 May;8(1)

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

Background: Previous trials showed that antiangiogenesis or anti-programmed death protein 1/programmed death ligand 1 (PD-1/PD-L1) monotherapy only showed marginal effect in triple-negative breast cancer (TNBC). Preclinical studies demonstrated that antiangiogenic therapy could sensitize breast cancer to PD-1/PD-L1 blockade via reprogramming tumor microenvironment. Combinational treatment of checkpoint blockade and antiangiogenesis for TNBC has not been reported. Read More

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http://dx.doi.org/10.1136/jitc-2020-000696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252975PMC

Extracellular vesicles from human urine-derived stem cells inhibit glucocorticoid-induced osteonecrosis of the femoral head by transporting and releasing pro-angiogenic DMBT1 and anti-apoptotic TIMP1.

Acta Biomater 2020 May 21. Epub 2020 May 21.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China; Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha, Hunan 410008, China. Electronic address:

Osteonecrosis of the femoral head (ONFH) frequently occurs after glucocorticoid (GC) treatment. Extracellular vesicles (EVs) are important nano-sized paracrine mediators of intercellular crosstalk. This study aimed to determine whether EVs from human urine-derived stem cells (USC-EVs) could protect against GC-induced ONFH and focused on the impacts of USC-EVs on angiogenesis and apoptosis to explore the mechanism by which USC-EVs attenuated GC-induced ONFH. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.020DOI Listing

Unexpected radiation pneumonitis after SIRT with significant decrease in DLCO with internal radiation exposure: a case report.

BMC Med Imaging 2020 May 19;20(1):52. Epub 2020 May 19.

Department of Nuclear Medicine, Marmara University Istanbul Pendik Education and Research Hospital, Fevzi Çakmak Mah. Muhsin Yazicioglu Cad. No:10 Ust Kaynarca / Pendik, 34899, Istanbul, Turkey.

Background: In the last years, Selective Internal Radiation Therapy (SIRT), using biocompatible Yttrium-90 (90Y) labeled microspheres have emerged for the treatment of malignant hepatic tumors. Unfortunately, a significant part of 90Y-labeled microspheres may shunt to the lungs after intraarterial injection. It can be predictable by infusing technetium-99 m-labeled macro-aggregated albumin particles through a catheter placed in the proper hepatic artery depending on the lobe to be treated with performing a quantitative lung scintigraphy. Read More

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http://dx.doi.org/10.1186/s12880-020-00452-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236282PMC

Nuclear CK19-immunopositive pseudoinclusions as a new additional objective diagnostic feature of papillary thyroid carcinoma.

Pol J Pathol 2020 ;71(1):1-6

Department of Pathology, Pomeranian Medical University, Szczecin, Poland.

One of the key parameters in the diagnosis of papillary thyroid carcinoma (PTC) are true nuclear pseudoinclusions (NPs), which constitute invaginations of the cytoplasm into the nucleus. On the other hand, strong cytoplasmic expression of CK19 is a well-known attribute of PTC tumor cells. We analyzed NPs using CK19 immunohistochemistry in histological sections of 52 PTCs and seven noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs). Read More

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http://dx.doi.org/10.5114/pjp.2020.95410DOI Listing
January 2020

Predictors of women's sexual outcomes after implant-based breast reconstruction.

Psychooncology 2020 May 17. Epub 2020 May 17.

Department of Plastic, Reconstructive and Hand Surgery, Amsterdam University Medical Center (VUmc), Amsterdam, The Netherlands.

Objective: Although breast reconstruction has become an important treatment modality following mastectomy, few studies assessed predictors of postoperative sexual outcomes after breast reconstruction. Therefore, we aimed to study three sexual outcomes following implant-based breast reconstruction (IBBR), and associate multiple biopsychosocial factors with these outcomes.

Methods: Data collection was part of a multicenter prospective study on IBBR. Read More

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http://dx.doi.org/10.1002/pon.5415DOI Listing

Radiotherapy during COVID-19 pandemic. How to create a No fly zone: a Northern Italy experience.

Radiol Med 2020 Jun 15;125(6):600-603. Epub 2020 May 15.

Radiation Oncology Unit, Radiotherapy Department, Santa Maria della Misericordia Hospital, ULSS5, Rovigo, Italy.

Background: SARS-CoV-2 pandemic represents a troubling health emergency but also a main challenge for the clinical governance of the system. Discontinuation of radiation treatments is not desirable and potentially life-threatening. On the other hand, accesses to hospital expose cancer patients to an increased risk of COVID-19 infection. Read More

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http://dx.doi.org/10.1007/s11547-020-01217-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227174PMC

Identification of Sonographic Features for Predicting Benign Versus Malignant Mediastinal or Hilar Lymph Nodes Using Endobronchial Ultrasound.

Oman Med J 2020 Mar 30;35(2):e112. Epub 2020 Apr 30.

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: In countries with a high prevalence of tuberculosis, such as Iran, the differentiation of malignant from non-malignant tumors is crucial. We attempted to find a reliable model in determining malignant nodes by investigating the sonographic characteristics of lymph nodes (LNs).

Methods: In this prospective study, the morphologic characteristics of LNs, including size, shape, vascular pattern, echogenicity, margin, coagulation necrosis sign, calcification, and central hilar structure, which had been obtained during endobronchial ultrasound-guided transbronchial needle aspiration, were compared with the final pathology results. Read More

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http://dx.doi.org/10.5001/omj.2020.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199125PMC

Epididymal leiomyoadenomatoid tumor: A case report with literature review.

Urol Case Rep 2020 Sep 24;32:101226. Epub 2020 Apr 24.

Department of Laboratory Medicine & Pathology, Hamad Medical Corporation, Doha, Qatar.

Primary epididymal tumors are rare. Adenomatoid tumors comprise 30% of paratesticular tumors. They are benign neoplasms originating from mesothelial cells. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205739PMC
September 2020

High expression of IGF2-derived intronic miR-483 predicts outcome in hepatoblastoma.

Cancer Biomark 2020 Apr 30. Epub 2020 Apr 30.

Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

Background: The role of microRNAs (miRs) as biomarkers to predict outcome in hepatoblastoma (HB), the most common malignant liver tumor in childhood, has still to be determined. Recently, the so-called four-miR signature has been described to efficiently stratify HB patients according to their prognosis.

Objective: We examined the recently described four-miR signature for its clinical relevance in an independent validation cohort of HB patients and tried to optimize its predictive value by analyzing four additional miRs involved in HB biology. Read More

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http://dx.doi.org/10.3233/CBM-191390DOI Listing

The efficacy and safety of capecitabine-based versus S-1-based chemotherapy for metastatic or recurrent gastric cancer: a systematic review and meta-analysis of clinical randomized trials.

Ann Palliat Med 2020 May 23;9(3):883-894. Epub 2020 Apr 23.

Institute of Clinical Research and Evidence-Based Medicine, Gansu Provincial Hospital, Lanzhou 730000, China; Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730030, China; Evidence-Based Medicine Center, School of Basic Medical Sciences, Evidence-Based Social Science Research Center, Lanzhou University, Lanzhou 730030, China.

Background: Gastric cancer (GC), particularly unresectable, metastatic, or recurrent GC, has been characterized by unfavorable prognosis. This meta-analysis of clinical randomized phase II trials was conducted to systematically evaluate the efficacy and safety of capecitabine-based versus S-1-based chemotherapy for metastatic or recurrent GC.

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library databases to identify studies eligible for the present analysis. Read More

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http://dx.doi.org/10.21037/apm.2020.04.26DOI Listing

A meta-analysis comparing hand-assisted laparoscopic right hemicolectomy and open right hemicolectomy for right-sided colon cancer.

World J Surg Oncol 2020 May 7;18(1):91. Epub 2020 May 7.

Department B of Surgery, Charles Nicolle Hospital, University Tunis El Manar, Tunis, Tunisia.

Background: Mini-invasive colorectal cancer surgery was adopted widely in recent years. This meta-analysis aimed to compare hand-assisted laparoscopic surgery (HALS) with open right hemicolectomy (OS) for malignant disease.

Methods: PRISMA guidelines with random effects model were adopted using Review Manager Version 5. Read More

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http://dx.doi.org/10.1186/s12957-020-01869-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206699PMC
May 2020
1.200 Impact Factor

CT Findings of Upper Urinary Tract Lesions in IgG4-Related Disease: Comparison With Urothelial Carcinoma.

AJR Am J Roentgenol 2020 May 6:1-7. Epub 2020 May 6.

Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

IgG4-related disease is characterized by extensive infiltration of IgG4-positive plasma cells and fibrosis in various organs. The objective of this study is to investigate CT findings of IgG4-related lesions involving the upper urinary tract and compare them with those of urothelial carcinomas. This study reviewed pretreatment CT images of 13 consecutive patients with IgG4-related disease with upper urinary tract lesions and 80 consecutive patients with urothelial carcinomas. Read More

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http://dx.doi.org/10.2214/AJR.19.22192DOI Listing

Age-related EBV-associated B-cell lymphoproliferative disorders and other EBV + lymphoproliferative diseases: New insights into immune escape and immunodeficiency through staining with anti-PD-L1 antibody clone SP142.

Pathol Int 2020 May 4. Epub 2020 May 4.

Department of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Nagano, Japan.

Epstein-Barr virus (EBV) is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age-related EBV-associated B-cell lymphoproliferative disorders (LPD) bearing a resemblance to immunodeficiency-associated ones. These LPDs may be associated with immune senescence and are now incorporated into the revised 4th edition of 2017 WHO lymphoma classification as EBV-positive (EBV+) diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS). Read More

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http://dx.doi.org/10.1111/pin.12946DOI Listing

The Effect of Pelvic Floor Muscle Interventions on Pelvic Floor Dysfunction After Gynecological Cancer Treatment: A Systematic Review.

Phys Ther 2020 May 4. Epub 2020 May 4.

School of Primary and Allied Health Care, Faculty of Medicine, Nursing; and Health Sciences, Monash University.

Objective: The aim of this systematic review was to identify, evaluate and synthesize the evidence from studies that have investigated the effect of nonsurgical, nonpharmacological, pelvic floor muscle interventions on any type of pelvic floor dysfunction or health-related quality of life in patients after any type of treatment for gynecological cancer.

Methods: Six electronic databases (Cochrane Library 2018, CINAHL 1982-2018, MEDLINE 1950-2018, EMBASE 1980-2018, PsycINFO 1806-2018, and EMCARE 1995-2018) were systematically searched in June 2018. Reference lists of identified articles were hand searched. Read More

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http://dx.doi.org/10.1093/ptj/pzaa081DOI Listing

Surgical Principles in the Management of Pancreatic Neuroendocrine Neoplasms.

Curr Treat Options Oncol 2020 Apr 30;21(6):48. Epub 2020 Apr 30.

Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Center, San Raffaele Hospital Neuroendocrine Tumor Group (ENETS Center of Excellence), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Opinion Statement: Pancreatic neuroendocrine neoplasms (PanNENs) are increasingly recognized entities, whose incidence has dramatically grown during the last two decades. Surgery plays a pivotal role in their management as it represents the only chance of cure. Since PanNENs display a wide range of aggressiveness, their surgical management needs to be tailored on tumor's and patient's characteristics. Read More

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http://dx.doi.org/10.1007/s11864-020-00736-wDOI Listing

A propensity-matched study of full laparoscopic versus hand-assisted minimal-invasive liver surgery.

Surg Endosc 2020 Apr 28. Epub 2020 Apr 28.

Department of Surgery, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background And Aim: The implications of multi-incision (MILS) and hand-assisted (HALS) laparoscopic techniques for minimally invasive liver surgery with regard to perioperative outcomes are not well defined. The purpose of this study was to compare MILS and HALS using propensity score matching.

Methods: 309 patients underwent laparoscopic liver resections (LLR) between January 2013 and June 2018. Read More

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http://dx.doi.org/10.1007/s00464-020-07597-2DOI Listing

Intraosseous Schwannoma: Case Report and Review of the Literature.

Rev Bras Ortop (Sao Paulo) 2020 Apr 19;55(2):258-262. Epub 2019 Dec 19.

Hospital AC Camargo Câncer Center de São Paulo, São Paulo, SP, Brasil.

Schwannoma is a benign neural sheath tumor of the soft tissue, and its intraosseous presentation is very rare. It is estimated that intraosseous schwannomas represent 0.2% of all bone tumors. Read More

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http://dx.doi.org/10.1016/j.rbo.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186061PMC

Diagnosing peripheral lung lesions using endobronchial ultrasonography with guide sheath: A prospective registry study to assess the effect of virtual bronchoscopic navigation using a computed tomography workstation.

Medicine (Baltimore) 2020 Apr;99(17):e19870

Department of Internal Medicine.

Bronchoscopy has a lower diagnostic yield for peripheral lung lesions (PLL). Endobronchial ultrasound guide sheath transbronchial lung biopsy (EBUS GS TBLB) has been used to overcome such limitation. Recent studies revealed that combined methods (e. Read More

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http://dx.doi.org/10.1097/MD.0000000000019870DOI Listing

Advances and perspectives of dendritic cell-based active immunotherapies in follicular lymphoma.

Cancer Immunol Immunother 2020 Jun 22;69(6):913-925. Epub 2020 Apr 22.

Dipartimento Di Oncologia e Medicina Molecolare, Istituto Superiore Di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

Follicular lymphoma (FL) is a remarkably immune-responsive malignancy, which is still considered incurable. As, standard immunochemotherapy is complex, toxic and not curative, improvement in FL care is now a crucial topic in hemato-oncology. Recently, we and others have shown that dendritic cell (DC)-based therapies allow a specific immune response associated with sustained lymphoma regression in a proportion of low-tumor burden FL patients. Read More

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http://dx.doi.org/10.1007/s00262-020-02577-wDOI Listing

s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide.

Cell Res 2020 Apr 15. Epub 2020 Apr 15.

Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.

Hand-foot skin reaction (HFSR), among the most significant adverse effects of sorafenib, has been limiting the clinical benefits of this frontline drug in treating various malignant tumors. The mechanism underlying such toxicity remains poorly understood, hence the absence of effective intervention strategies. In the present study, we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor (s-HBEGF) mediates the crosstalk between vascular endothelial cells and keratinocytes. Read More

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http://dx.doi.org/10.1038/s41422-020-0309-6DOI Listing

Precision medicine in medical oncology: hope, disappointment and reality.

Clin Chem Lab Med 2020 Apr 9. Epub 2020 Apr 9.

Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic.

During the past 20 years, targeted therapy based on the understanding of tumor biology has been complementing or even replacing cytotoxic agents that have dominated pharmacotherapy of cancer since the conception of medical oncology. Unfortunately, the fact that targeted therapies with potential to induce cure or at least substantially prolong survival are still not available for many common solid tumors results in skepticism or even nihilism. On the one hand, biomarker research is not keeping pace with the introduction of new agents, while on the other hand, effective drugs are still not available for many potential molecular targets associated with malignant transformation and tumor progression. Read More

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http://dx.doi.org/10.1515/cclm-2020-0231DOI Listing

Prophylactic human papillomavirus vaccination to prevent recurrence of cervical intraepithelial neoplasia: a meta-analysis.

Int J Gynecol Cancer 2020 Jun 9;30(6):777-782. Epub 2020 Apr 9.

Ireland East Hospital Gynaeoncology Group, Mater Misericordiae University Hospital, Dublin, Ireland.

Objective: The aim of this systematic review and meta-analysis was to review evidence supporting the use of prophylactic human papillomavirus (HPV) vaccines to influence the risk of recurrence of cervical intraepithelial neoplasia after surgical treatment.

Methods: A systematic literature search was performed for publications reporting risk of recurrence of cervical intraepithelial neoplasia after surgical treatment in patients receiving HPV vaccination (either in the prophylactic or adjuvant setting). Comprehensive searches of six electronic databases (MEDLINE, Embase, Web of Science, PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and references of identified studies) from their inceptions were performed (English language only), and hand search reference lists were performed. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001197DOI Listing

Divergent Modulation of Proteostasis in Prostate Cancer.

Adv Exp Med Biol 2020 ;1233:117-151

Faculty of Pharmacy, Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey.

Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly associated with tumorigenesis since it specifically targets key oncoproteins and tumor suppressors. Prostate cancer (PCa) is the second most common cause of cancer death in men worldwide. Read More

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http://dx.doi.org/10.1007/978-3-030-38266-7_5DOI Listing

The Iberian legacy into a young genetic xeroderma pigmentosum cluster in central Brazil.

Mutat Res 2020 04 29;852:503164. Epub 2020 Feb 29.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

In central Brazil, in the municipality of Faina (state of Goiás), the small and isolated village of Araras comprises a genetic cluster of xeroderma pigmentosum (XP) patients. The high level of consanguinity and the geographical isolation gave rise to a high frequency of XP patients. Recently, two founder events were identified affecting that community, with two independent mutations at the POLH gene, c. Read More

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http://dx.doi.org/10.1016/j.mrgentox.2020.503164DOI Listing

Modeling Cell Communication in Cancer With Organoids: Making the Complex Simple.

Front Cell Dev Biol 2020 18;8:166. Epub 2020 Mar 18.

Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Homotypic and heterotypic interactions between cells are of crucial importance in multicellular organisms for the maintenance of physiological functions. Accordingly, changes in cell-to-cell communication contribute significantly to tumor development. Cancer cells engage the different components of the tumor microenvironment (TME) to support malignant proliferation, escape immune control, and favor metastatic spreading. Read More

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http://dx.doi.org/10.3389/fcell.2020.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094029PMC

Chondromyxoid Fibroma of Distal Phalanx of the Great Toe: A Rare Clinical Entity.

Cureus 2020 Feb 28;12(2):e7133. Epub 2020 Feb 28.

Orthopaedics, Siddhartha Medical College, Vijayawada, IND.

Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. Read More

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http://dx.doi.org/10.7759/cureus.7133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105257PMC
February 2020

Comparison of Strength of Anastomosis Between Four Different Techniques for Colorectal Surgery.

Anticancer Res 2020 Apr;40(4):1891-1896

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Background/aim: Advances in stapling devices have led to their widespread use in colorectal surgery. We compared the strength of four types of anastomoses using bursting pressure.

Materials And Methods: We created stapled anastomosis models [double stapling technique (DST), functional end-to-end anastomosis (FEEA) unbuttressed or buttressed, and triangulating anastomosis (TA) with two- or three-row stapling] and a hand-sewn anastomosis model. Read More

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http://dx.doi.org/10.21873/anticanres.14143DOI Listing

[Value of lenvatinib for the treatment of advanced hepatocellular carcinoma].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(11):833-836

Department of Interventional Radiology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

To observe the safety and efficacy of lenvatinib for the treatment of medium-advanced hepatocellular carcinoma. A total of 36 patients with medium-advanced hepatocellular carcinoma from the First Medical Center of the Chinese PLA General Hospital were retrospectively analyzed from January 2018 to May 2019. All patients had shown tumor progression after at least 2 sessions of TACE. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190818-01832DOI Listing

Early Adverse Events predict Survival Outcomes in HER2-positive Advanced Breast Cancer Patients treated with Lapatinib plus Capecitabine.

J Cancer 2020 5;11(11):3327-3333. Epub 2020 Mar 5.

College of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, Australia.

: This study aimed to investigate the impact of early adverse events (AE) following the initiation of lapatinib plus capecitabine on the progression-free survival (PFS) and overall survival (OS) outcomes of human epidermal growth factor receptor 2 (HER2) positive advanced breast cancer (ABC) patients. : A secondary analysis of participants treated with lapatinib plus capecitabine, or ado-trastuzumab emtansine in the clinical trial EMILIA was conducted. Cox proportional hazard analysis was used to assess the impact of AE occurring within the first 42 days of lapatinib plus capecitabine therapy on the PFS and OS outcomes of ABC patients. Read More

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http://dx.doi.org/10.7150/jca.41996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097941PMC

Oncological Resection for Liver Malignancies: Can the Laparoscopic Approach Provide Benefits?

Ann Surg 2020 Mar 27. Epub 2020 Mar 27.

Department of HPB Surgery and Transplantation, Beaujon Hospital, Assistance Publique - Hôpitaux de Paris, France; Université Paris VII Denis Diderot, France.

: Laparoscopic surgery has become an increasingly popular alternative approach to open surgery, resulting in a paradigm shift in liver surgery. Although laparoscopic liver resection (LLR) was initially indicated for small benign and peripheral tumors, at present more than half of LLRs are performed in malignant tumors. Several studies have reported the feasibility of LLR in malignant disease and suggested various short-term benefits compared to open liver resection, including decreased blood loss and postoperative complications and a shorter hospital stay. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003851DOI Listing

Monte Carlo dose calculations of shielding disks with different material combinations in intraoperative electron radiation therapy (IOERT).

Cancer Radiother 2020 Apr 26;24(2):128-134. Epub 2020 Mar 26.

Radiothérapy Department, institut Jules-Bordet, Bruxelles, Belgium.

Purpose: Shielding disks play an important role in intraoperative electron radiation therapy, and different designs are currently used in clinical practice. This paper investigates the dosimetric impact of the shielding disk used during intraoperative electron radiation therapy (IOERT).

Materials And Methods: This paper focuses on the study of four shielding disks types that have been used in our clinic: Aluminum (Al)/Lead (Pb), PMMA/Copper(Cu)/PMMA, Aluminum (Al)/Copper (Cu) and Aluminum (Al)/Steel with their specific thicknesses. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.006DOI Listing

Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review.

Cancer Biol Ther 2020 Jul 25;21(7):583-589. Epub 2020 Mar 25.

Department of Neurosurgery, Shandong Cancer Hospital Affiliated to Shandong University; Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences , Jinan, China.

Up to now, no proven effective medical therapy for surgery and radiation-refractory anaplastic meningioma (AM) exists. Patients with vascular endothelial growth factor receptor 2 (VEGFR-2) positive meningiomas showed significantly shorter progression-free survival. Apatinib is a small-molecule antiangiogenic agent that selectively inhibits VEGFR-2. Read More

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http://dx.doi.org/10.1080/15384047.2020.1740053DOI Listing

Clinical Significance of CD200 and CD56 Expression in Patients with Acute Myeloid Leukemia.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):743-748. Epub 2020 Mar 1.

Hematology Unit, Oncology Center, Mansoura University, Egypt.

Background: Acute myeloid leukemia (AML) escape from immunosurveillance by immunosuppression. CD200 and CD56 expression represented an independent prognostic factor in many hematological malignancies but its importance in AML patients remains to be identified.

Methods: CD200 and CD56 expression were assessed in the bone marrow blasts for Fifty-two (52) newly diagnosed AML by flowcytometry before start of therapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.743DOI Listing
March 2020
1.500 Impact Factor

Influence of HLA 1-3-locus mismatch and antithymocyte globulin administration in unrelated bone marrow transplantation.

Ann Hematol 2020 May 23;99(5):1099-1110. Epub 2020 Mar 23.

Division of Hematology, Jichi Medical University Saitama Medical Center, 1-847, Amanuma-cho, Omiya-ku, Saitama-city, Saitama, 330-8503, Japan.

For patients without an HLA-matched donor, an HLA-mismatched unrelated donor (MMUD) has been considered as an alternative donor in allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a nationwide retrospective study to compare the transplant outcomes among 1-, 2-, and 3-locus (allele/antigen) mismatched unrelated donors (1MMUD n = 2044, 2MMUD n = 492, and 3MMUD n = 73) in allo-HCT and to assess the impact of antithymocyte globulin (ATG) in allo-HCT from 1-3MMUD. 2MMUD and 3MMUD were independent significant adverse factors for grade III-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR] 1. Read More

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http://dx.doi.org/10.1007/s00277-020-03995-7DOI Listing

Physical activity level and age contribute to functioning problems in patients with breast cancer-related lymphedema: a multicentre cross-sectional study.

Support Care Cancer 2020 Mar 19. Epub 2020 Mar 19.

Department of Rehabilitation Sciences, KU Leuven, University of Leuven, Leuven, Belgium.

Purpose: Breast cancer survivors face a high risk of developing breast cancer-related lymphedema (BCRL). Besides physical symptoms such as swelling, BCRL can have a psychosocial impact and lead to problems in daily functioning. Understanding contributing variables to problems in functioning yields possibilities to improve treatment modalities and consequently patients' quality of life. Read More

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http://dx.doi.org/10.1007/s00520-020-05375-3DOI Listing

Small Molecular Immune Modulators as Anticancer Agents.

Adv Exp Med Biol 2020 ;1248:547-618

PrimeGene (Beijing) Co., Ltd., Fengtai District, Beijing, 100070, China.

After decades of intense effort, immune checkpoint inhibitors have been conclusively demonstrated to be effective in cancer treatments and thus are revolutionizing the concepts in the treatment of cancers. Immuno-oncology has arrived and will play a key role in cancer treatment in the foreseeable future. However, efforts to find novel methods to improve the immune response to cancer have not ceased. Read More

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http://dx.doi.org/10.1007/978-981-15-3266-5_22DOI Listing

Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Is a Potential Prognostic Biomarker and Promotes Cell Progression in Prostate Cancer.

Cancer Manag Res 2020 6;12:1649-1660. Epub 2020 Mar 6.

Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji 133002, Jilin Province, People's Republic of China.

Purpose: The leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is a mitochondrial protein that has been associated with the occurrence and development of malignant tumors. Previous studies have shown that LETM1 expression is increased in several types of human cancer and is associated with a poor clinical outcome. However, the role of LETM1 in prostate cancer (PCa) has not yet been determined. Read More

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http://dx.doi.org/10.2147/CMAR.S236482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064284PMC

Apatinib combined with chemotherapy or concurrent chemo-brachytherapy in patients with recurrent or advanced cervical cancer: A phase 2, randomized controlled, prospective study.

Medicine (Baltimore) 2020 Mar;99(11):e19372

Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University, Qingdao.

Objective: Apatinib mesylate is a novel vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which has exhibited good safety and efficacy in several types of solid tumors. The present study aimed to assess the clinical efficacy and safety of apatinib combined with chemotherapy and concurrent chemo-brachytherapy (CCBT) in patients with recurrent and advanced cervical cancer.

Methods: A total of 52 patients with first diagnosed recurrent or untreated International Federation of Gynecology and Obstetrics stage IVB cervical cancer admitted at Shandong Cancer Hospital and Institute between July 2016 and May 2018 were analyzed in the current randomized controlled trial. Read More

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http://dx.doi.org/10.1097/MD.0000000000019372DOI Listing

European perspective on the use of molecular tests in the diagnosis and therapy of thyroid neoplasms.

Gland Surg 2020 Feb;9(Suppl 2):S69-S76

The Oncologic and Reconstructive Surgery Clinic, Maria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Gliwice, Poland.

Thyroid nodules are frequently observed, particularly in individuals of over 60 years of age. On the other hand, most of the detected changes are benign and they do not require surgery. Therefore, differentiation between benign and malignant lesions in preoperative diagnosis is of crucial importance. Read More

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http://dx.doi.org/10.21037/gs.2019.10.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044080PMC
February 2020

[Combination of Oncolytic Virotherapy and CAR T/NK Cell Therapy for the Treatment of Cancer].

Mol Biol (Mosk) 2020 Jan-Feb;54(1):3-16

Institute of Molecular and Cellular Biology, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.

Multiple lines of evidence indicate that CAR-T cell based therapy and oncolytic virotherapy display robust performance in both immunocompetent and immunodeficient mouse models. Rare, yet highly successful attempts to combine these therapeutic platforms have also been reported. Interestingly, both approaches have shown pronounced efficacy in human trials, albeit these were limited to just a handful of malignancies. Read More

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http://dx.doi.org/10.1134/S0026893320010100DOI Listing

[Treatment decisions in oncology : Walking the tightrope between honesty and hope, lifetime, and quality of life].

HNO 2020 Mar 11. Epub 2020 Mar 11.

Medizinische Klinik II, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Background: A cancer diagnosis is always associated with a threat to life and therefore demands a great deal of the decision maker. For patients, this means making decisions under high emotional stress. On the other hand, medical facts can limit freedom of choice. Read More

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http://dx.doi.org/10.1007/s00106-020-00842-zDOI Listing

[Laparoscopic Gastro-Jejunostomy Using the Overlap Method after Subtotal Gastrectomy for Upper Gastric Cancer].

Gan To Kagaku Ryoho 2019 Dec;46(13):2195-2197

Division of Gastroenterological Surgery, Chiba Cancer Center.

Background: Due to an aging society, patients with gastric cancer are also getting older. Although total gastrectomy should be avoided for elderly patients, laparoscopic subtotal gastrectomy(LSTG)is a technically demanding procedure. Here, we present a safe procedure of gastro-jejunostomy using the overlap method. Read More

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December 2019

A nodule on the forearm.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an.

Glomus tumors are benign tumors of the skin. Clinically, these tumors can present as solid, painful subcutaneous nodules, frequently seen on the hand (particularly subungual region). Glomangiomyomas are the least common histological type of glomus tumor. Read More

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January 2020

Experimental Evidence and Clinical Implications of Pituitary Adenoma Stem Cells.

Front Endocrinol (Lausanne) 2020 20;11:54. Epub 2020 Feb 20.

Section of Pharmacology, Dipartimento di Medicina Interna and Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, Genoa, Italy.

Pituitary adenomas, accounting for 15% of diagnosed intracranial neoplasms, are usually benign and pharmacologically and surgically treatable; however, the critical location, mass effects and hormone hypersecretion sustain their significant morbidity. Approximately 35% of pituitary tumors show a less benign course since they are highly proliferative and invasive, poorly resectable, and likely recurring. The latest WHO classification of pituitary tumors includes pituitary transcription factor assessment to determine adenohypophysis cell lineages and accurate designation of adenomas, nevertheless little is known about molecular and cellular pathways which contribute to pituitary tumorigenesis. Read More

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http://dx.doi.org/10.3389/fendo.2020.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044184PMC
February 2020

Refractory solitary cervical lymph node metastasis after esophageal squamous cell carcinoma surgery and its successful treatment with immune checkpoint inhibitor: A case report and literature review.

Medicine (Baltimore) 2020 Mar;99(10):e19440

Cancer Center.

Rationale: Although the early detection and treatment of non-metastatic esophageal cancer has improved, these patients' prognoses are still poor. Most patients with radical treatment for esophageal cancer will relapse in 3 years, and the best treatment strategy after recurrence has not been uniformly accepted. Multiform treatments may be beneficial to recurrent patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000019440DOI Listing
March 2020
5.723 Impact Factor