45,642 results match your criteria Hand Malignant Tumors

[Predisposition and progression of myelodysplastic syndromes].

Hideki Makishima

Rinsho Ketsueki 2021 ;62(4):278-288

Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

Recent advances in sequencing technologies have increased the detection rate for identifying germline mutations that predispose an individual to various myeloid neoplasms and somatic mutations acquired during progression from myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML). In addition to pediatric subjects, adult patients were analyzed in order to obtain a complete spectrum of driver mutations in germline cells and/or somatic tumor samples. As shown in several recent studies, such driver mutations are acquired in a gene-specific fashion. Read More

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Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo.

Adv Exp Med Biol 2021 ;1269:157-161

Julius-Bernstein-Institute of Physiology, University of Halle-Wittenberg, Halle (Saale), Germany.

In comparison to normal tissue, solid tumors show an acidic extracellular pH, which results from hypoxia-induced glycolytic metabolism and the Warburg effect. Since acidosis modulates the expression of different microRNAs (e.g. Read More

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Cervical intradural intramedullary collision tumor of schwannoma and hemangioblastoma origin.

Surg Neurol Int 2021 14;12:155. Epub 2021 Apr 14.

Department of Neurosurgery, Mayo Clinic, Scottsdale, Arizona, United States.

Background: Primary spinal tumors are rare benign lesions that represent around 2-4% of all central nervous system neoplasms.[1,2] Intradural intramedullary tumors are predominately glial in origin and are most commonly astrocytomas or ependymomas. Intradural extramedullary tumors, on the other hand, are usually neurofibromas, schwannomas, or meningiomas. Read More

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Some Reactive Lesions of Bone Are Probably Neoplasms: A Review.

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

From the Departments of Pathology & Genetics, University of Alabama at Birmingham.

Context.—: A number of fibro-osseous and osteocartilaginous lesions, especially common in the small bones of hand and feet, pose a diagnostic challenge and have historically been thought to be reactive lesions. However, modern molecular techniques when supplementing clinical, radiographic, and histologic evaluation suggest they may, in fact, be neoplasms. Read More

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Clinicopathological Characteristics and Prognosis of Poorly Differentiated Thyroid Carcinoma Diagnosed According to the Turin Criteria.

Endocr Pract 2021 May 15;27(5):401-407. Epub 2020 Dec 15.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China. Electronic address:

Objective: Poorly differentiated thyroid carcinoma (PDTC) is the primary cause of death in patients with nonanaplastic follicular cell-derived thyroid carcinoma. We purposed to identify the clinical and pathological characteristics of PDTC and their relationship with prognosis.

Methods: A retrospective analysis was conducted on patients diagnosed with PDTC at our institution from 2010 to 2018. Read More

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Repeat limited fasciectomy is a safe and effective treatment for recurrence of Dupuytren's disease.

Bone Joint J 2021 May;103-B(5):946-950

Department of Trauma and Orthopaedic Surgery, St Mary's Hospital, London, UK.

Aims: The results of surgery for Dupuytren's disease can be compromised by the potential for disease recurrence and loss of function. Selecting which patients will benefit from repeat surgery, when to operate, and what procedure to undertake requires judgement and an understanding of patient expectations and functional needs. We undertook this study to investigate patient outcomes and satisfaction following repeat limited fasciectomy for recurrent Dupuytren's disease. Read More

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Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy.

Front Oncol 2021 13;11:644454. Epub 2021 Apr 13.

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This important role is mainly modulated by the composition of microbiota, as a normal microbiota composition is responsible for maintaining the homeostasis of human body, while an altered microbiota profile could contribute to several pathogenic conditions and may further lead to oncogenesis and tumor progression. Read More

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Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas.

Brain Sci 2021 Apr 7;11(4). Epub 2021 Apr 7.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.

Microglia, a type of differentiated tissue macrophage, are considered to be the most plastic cell population of the central nervous system (CNS). Microglia substantially contribute to the growth and invasion of tumor mass in brain tumors including glioblastoma (GB). In response to pathological conditions, resting microglia undergo a stereotypic activation process and become capable of phagocytosis, antigen presentation, and lymphocyte activation. Read More

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Epidemiology of lung cancer.

Contemp Oncol (Pozn) 2021 23;25(1):45-52. Epub 2021 Feb 23.

Hematologist-Oncologist, Allegheny Health Network, Pittsburgh, PA, USA.

Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the second most common cancer diagnosis in men and women (after prostate and breast cancer, respectively). Read More

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February 2021

Serum midkine is a more sensitive predictor for hepatocellular carcinoma than Dickkopf-1 and alpha-L-fucosidase in cirrhotic HCV patients.

Medicine (Baltimore) 2021 Apr;100(17):e25112

Hepatology, Gastroentrology and Infectious Diseases Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Abstract: Alpha fetoprotein (AFP) level is the gold standard diagnostic tool for detection and monitoring hepatocellular carcinoma (HCC) but with low sensitivity. Thus, the identification of alternative or combined serum markers of HCC is highly needed. Therefore, the aim of this work was to verify the value of serum midkine (MDK), Dickkopf-related protein 1 (DKK1), and alpha-L-fucosidase (AFU) in detection of HCC. Read More

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Antibody Therapy: From Diphtheria to Cancer, COVID-19, and Beyond.

Monoclon Antib Immunodiagn Immunother 2021 Apr;40(2):36-49

National Institute of Animal Biotechnology, Hyderabad, India.

The dawn of the 20th century saw the formative years of developments in immunology. In particular, immunochemistry, specifically pertaining to antibodies, was extensively studied. These studies laid the foundations for employing antibodies in a variety of ways. Read More

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Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2.

Front Cell Dev Biol 2021 8;9:638508. Epub 2021 Apr 8.

Department of Experimental Medicine, Sapienza University, Rome, Italy.

The Hedgehog (Hh) signaling pathway plays a crucial role in normal embryonic development and adult tissue homeostasis. On the other end, dysregulated Hh signaling triggers a prolonged mitogenic response that may prompt abnormal cell proliferation, favoring tumorigenesis. Indeed, about 30% of medulloblastomas (MBs), the most common malignant childhood cerebellar tumors, exhibit improper activation of the Hh signaling. Read More

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Machine learning to reveal an astute risk predictive framework for Gynecologic Cancer and its impact on women psychology: Bangladeshi perspective.

BMC Bioinformatics 2021 Apr 24;22(1):213. Epub 2021 Apr 24.

Department of Software Engineering, Daffodil International University, Dhanmondi, Dhaka, Bangladesh.

Background: In this research, an astute system has been developed by using machine learning and data mining approach to predict the risk level of cervical and ovarian cancer in association to stress.

Results: For functioning factors and subfactors, several machine learning models like Logistics Regression, Random Forest, AdaBoost, Naïve Bayes, Neural Network, kNN, CN2 rule Inducer, Decision Tree, Quadratic Classifier were compared with standard metrics e.g. Read More

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Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer.

Oncotarget 2021 Apr 13;12(8):807-822. Epub 2021 Apr 13.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.

Higher epidermal growth factor receptor (EGFR) signaling can contribute to tumor metastasis and resistance to therapies in oral squamous cell carcinoma (OSCC). EGFR signaling can promote epithelial-mesenchymal transition (EMT) in OSCC. EMT is a process by which epithelial cells acquire invasive properties and it can contribute to tumor metastasis. Read More

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The association of breast cancer-related lymphedema after unilateral mastectomy with shoulder girdle kinematics and upper extremity function.

J Biomech 2021 Apr 11;121:110432. Epub 2021 Apr 11.

Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. Electronic address:

The purpose of this study was to examine the association of breast cancer-related lymphedema on shoulder girdle kinematics and upper extremity function. The study included 67 breast cancer survivors with and without unilateral lymphedema. Individuals were divided into non-lymphedema, moderate and severe lymphedema groups according to the volumetric measurement difference between the affected and unaffected upper extremities. Read More

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Alternatives to free flap surgery for maxillofacial reconstruction: focus on the submental island flap and the pectoralis major myocutaneous flap.

BMC Oral Health 2021 04 19;21(1):198. Epub 2021 Apr 19.

Department of Cranio-Maxillofacial Surgery, University Medical Center Regensburg, 93042, Regensburg, Germany.

Background: Microvascular tissue transfer (MTT) has been established as the gold standard in oral- and maxillofacial reconstruction. However, free flap surgery may be critical in multimorbid elderly patients and after surgery or radiotherapy, which aggravate microsurgery. This study evaluates indications and outcome of the submental island flap (SMIF) and the pectoralis major myocutaneous flap (PMMF) as alternatives to the free radial forearm flap (RFF). Read More

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Not Just Uterine Adenocarcinoma-Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (): A Review.

Berit Baum

Vet Pathol 2021 Apr 20:3009858211002190. Epub 2021 Apr 20.

Vet Med Labor GmbH, Kornwestheim, Germany.

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Read More

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A Patient with an Ileocecal MiNEN and a Synchronous Squamous Non-Small-Cell Lung Cancer: Case Report and Review of the Literature.

Case Rep Oncol Med 2021 31;2021:8896254. Epub 2021 Mar 31.

Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.

Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are rare tumors composed of two different histological components, one of which is of a neuroendocrine origin. Given its suggested underdiagnosis and consequent low prevalence, no clear diagnostic and treatment guidelines are available, and treatment usually follows regimens similar to that of the most aggressive component. On the other hand, multiple primary tumors (MPTs) are also rare neoplastic entities that usually confer a challenge regarding treatment options, for a regimen that comprises both the primary and the synchronous/metachronous malignancy should be used. Read More

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Dorsal approach with tailored partial sacrectomy and gluteal V-Y fasciocutaneous advancement flap for the management of recurrent pelvic sepsis; case report.

BMC Surg 2021 Apr 15;21(1):194. Epub 2021 Apr 15.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Background: Pelvic sepsis after surgery for rectal cancer is a severe complication, mostly originating from anastomotic leakage. Complex salvage surgery, during which an omentoplasty is often used for filling of the pelvic cavity, is seldomly required. If this fails, a symptomatic recurrent presacral abscess with a risk of progressive inflammation can develop. Read More

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Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study.

Pan Afr Med J 2021 15;38:43. Epub 2021 Jan 15.

Department of Histology and Cytology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Introduction: recent studies show a good relationship between breast cancer (BC) and human papillomaviruses (HPV) wich is responsible for about 18% of BC cases. This study aimed to assess the relationship between different genotypes of HPV and the expression of P53 and retinoblastoma (RB) genes and estrogen and progesterone receptors in BC among Sudanese women.

Methods: one hundred and fifty tissue blocks were obtained from females diagnosed with BC. Read More

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Cross-cultural adaptation and validation of the Turkish version of the Musculoskeletal Tumor Society scoring system in patients with musculoskeletal tumors.

Acta Orthop Traumatol Turc 2021 Mar;55(2):141-146

Department of Orthopedics and Traumatology, Koç University, School of Medicine, İstanbul, Turkey.

Objective: This study aimed to translate and cross-culturally adapt the musculoskeletal tumor society (MSTS) scoring system into Turkish and to determine the reliability and validity of the translated version for the functional evaluation of patients with musculoskeletal tumors.

Methods: A total of 36 patients (16 women, 20 men; mean age=36.6; age range=13-75 years) who underwent limb-salvage surgery owing to benign aggressive or malignant musculoskeletal tumors were included in the study. Read More

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Intractable Fractures of the Bilateral Proximal Ulnae After 8 Years of Zoledronate Treatment for Breast Cancer Bone Metastasis.

J Hand Surg Am 2021 Apr 9. Epub 2021 Apr 9.

Department of Orthopaedic Surgery, School of Medicine, Kyoto University, Kyoto, Japan.

Long-term administration of bisphosphonates strongly suppresses osteoclastic bone resorption and rarely causes atypical fractures. This report presents a case of bilateral atypical ulnar fractures, following an 8-year course of zoledronate to treat breast cancer bone metastasis. Nonsurgical treatment for the left ulnar fracture failed, in spite of minimal displacement with callus formation at initial presentation. Read More

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Osteoblastoma of the Distal Radius.

J Hand Surg Am 2021 Apr 8. Epub 2021 Apr 8.

Department of Pathology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.

Osteoblastomas are rare, benign, bone-forming neoplasms that represent less than 1% of all bone tumors and occur mostly in people aged 10 to 30 years. In long bones, the metadiaphyseal region tends to be most commonly affected. However, to the best of our knowledge, only 11 cases have been reported to occur in the distal radius. Read More

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[Relationship between neutrophil phenotypic and functional heterogeneity and diseases].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):360-363

Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin 300100, China. Corresponding author: Wang Ximo, Email:

Neutrophils are the most abundant circulating leukocyte type in humans and comprise the host's first line of cellular defense against foreign pathogens invasion. On the other hand, neutrophils are the main mediators of tissue damage induced by acute and chronic inflammation. They were once considered to be short-lived, low transcriptional activity, and terminally differentiated homogeneous leucocytes that failed to return to circulation from tissue. Read More

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Improving the Prediction of Benign or Malignant Breast Masses Using a Combination of Image Biomarkers and Clinical Parameters.

Front Oncol 2021 22;11:629321. Epub 2021 Mar 22.

Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Breast cancer is one of the leading causes of death in female cancer patients. The disease can be detected early using Mammography, an effective X-ray imaging technology. The most important step in mammography is the classification of mammogram patches as benign or malignant. Read More

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A Podobed

Georgian Med News 2021 Feb(311):33-36

Department of Thoracic Surgery, N.N. Alexandrov National Cancer Center of Belarus, Minsk, Belarus.

Lipomas of the major central veins are very rare tumors that have mostly been described in the inferior vena cava. They may be identified in as many as 0.5% of all CT scans. Read More

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February 2021

Chondrosarcomas of the small bones: analysis of 44 patients.

Eur J Orthop Surg Traumatol 2021 Apr 3. Epub 2021 Apr 3.

First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Background: Chondrosarcomas of the small bones of the hands and feet are uncommon and account for less than 2% of all chondrosarcomas in the skeleton; a 4.2% rate of malignant degeneration of enchondromas to secondary chondrosarcomas has been reported. We performed this study to assess the outcome of the patients with chondrosarcomas of the small bones. Read More

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Clinical Potential of Kinase Inhibitors in Combination with Immune Checkpoint Inhibitors for the Treatment of Solid Tumors.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada.

Oncogenic kinases contribute to immunosuppression and modulate the tumor microenvironment in solid tumors. Increasing evidence supports the fundamental role of oncogenic kinase signaling networks in coordinating immunosuppressive tumor microenvironments. This has led to numerous studies examining the efficacy of kinase inhibitors in inducing anti-tumor immune responses by increasing tumor immunogenicity. Read More

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Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

Int J Mol Sci 2021 Mar 10;22(6). Epub 2021 Mar 10.

Institute for Applied Microelectronics (IUMA), University of Las Palmas de Gran Canaria (ULPGC), 35017 Las Palmas de Gran Canaria, Spain.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. Read More

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EGCG Inhibits Adipose-Derived Mesenchymal Stem Cells Differentiation into Adipocytes and Prevents a STAT3-Mediated Paracrine Oncogenic Control of Triple-Negative Breast Cancer Cell Invasive Phenotype.

Molecules 2021 Mar 10;26(6). Epub 2021 Mar 10.

Laboratoire d'Oncologie Moléculaire, Département de Chimie, Centre de Recherche CERMO-FC, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

Obese subjects have an increased risk of developing triple-negative breast cancer (TNBC), in part associated with the chronic low-grade inflammation state. On the other hand, epidemiological data indicates that increased consumption of polyphenol-rich fruits and vegetables plays a key role in reducing incidence of some cancer types. Here, we tested whether green tea-derived epigallocatechin-3-gallate (EGCG) could alter adipose-derived mesenchymal stem cell differentiation into adipocytes, and how this impacts the secretome profile and paracrine regulation of the TNBC invasive phenotype. Read More

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