42,035 results match your criteria Hand Malignant Tumors


High resolution MRI of nail tumors and tumor-like conditions.

Eur J Radiol 2019 Mar 6;112:93-105. Epub 2019 Jan 6.

Division of Radiology, Department of Imaging and Medical Informatics, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland. Electronic address:

Although the nail is a small anatomical structure, it can be affected by various tumors and tumor-like conditions. Because of the distinctive nail anatomy, the clinical presentation of tumors is modified, thus rendering the diagnosis challenging. As nail biopsy and surgery are painful procedures associated with an increased risk of permanent onychodystrophy, pre-operative diagnosis is desirable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193000
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http://dx.doi.org/10.1016/j.ejrad.2019.01.004DOI Listing
March 2019
1 Read

Sleeve-Shaped Neurothekeoma of the Ulnar Nerve: A Unique Case of a Still Unclear Pathological Entity.

Hand (N Y) 2019 Feb 14:1558944719828008. Epub 2019 Feb 14.

1 Fondazione I.R.C.C.S Istituto Neurologico Carlo Besta, Milan, Italy.

Background: Neurothekeomas are slow-growing, well-circumscribed benign neoplasms. They usually involve cutaneous or subcutaneous tissues. Although originally described as myxomas deriving from nerve sheath cells, their exact histological classification is still uncertain. Read More

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http://dx.doi.org/10.1177/1558944719828008DOI Listing
February 2019
1 Read

Chondrosarcoma of the Hand Bones: A Report of 6 Cases and Review of the Literature.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):45-49

‡ Division of Trauma, Department of Orthopedic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Background: Primary malignant tumours of the hand are extremely rare, with chondrosarcoma being the most common. We describe six consecutive cases of chondrosarcoma (CS) of the hand, with a follow-up of 12 months to 10 years after surgical intervention.

Methods: Five cases were primary tumors and one was secondary to Ollier's disease. Read More

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http://dx.doi.org/10.1142/S2424835519500085DOI Listing

Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.

Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas. Read More

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http://www.nature.com/articles/s41379-018-0199-z
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http://dx.doi.org/10.1038/s41379-018-0199-zDOI Listing
February 2019
3 Reads

Overexpression of Adenoviral E1A Sensitizes E1A+Ras-Transformed Cells to the Action of Histone Deacetylase Inhibitors.

Acta Naturae 2018 Oct-Dec;10(4):70-78

Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave., 4, St-Petersburg, 194064, Russia.

The adenoviral E1A protein induces cell proliferation, transformation, and tumor formation in rodents, on the one hand. On the other hand, E1A expression increases cell sensitivity to a number of cytotoxic agents. Therefore, E1A is a candidate for use as a component of combination therapy for malignant tumors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351034PMC
February 2019

The association between benzodiazepines and survival in patients with cancer: a systematic review.

J Pain Symptom Manage 2019 Jan 29. Epub 2019 Jan 29.

Hull York Medical School, University of Hull, Hull, United Kingdom, HU6 7RX.

Context: Patients with cancer often experience distressing symptoms such as anxiety or dyspnea, which can be managed with benzodiazepines. However, concerns regarding the impact of these drugs on survival may dissuade prescribing and compliance.

Objectives: We aimed to identify and appraise studies examining benzodiazepine use and survival in adults with cancer, to investigate the relationship and context of use. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.01.010DOI Listing
January 2019

Intramuscular hemangioma within the biceps brachii causing the limitations of elbow extension and forearm pronation: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14343

Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.

Rationale: Intramuscular hemangiomas are rare benign vascular neoplasms, merely accounting for 0.8% of all hemangiomas. Moreover, there are few case reports of intramuscular hemangiomas in the upper extremities. Read More

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http://dx.doi.org/10.1097/MD.0000000000014343DOI Listing
February 2019
9 Reads

Unravelling the Interplay between Extracellular Acidosis and Immune Cells.

Mediators Inflamm 2018 30;2018:1218297. Epub 2018 Dec 30.

Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires, CONICET, Ciudad de Buenos Aires, Argentina.

The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6. Read More

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https://www.hindawi.com/journals/mi/2018/1218297/
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http://dx.doi.org/10.1155/2018/1218297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332927PMC
December 2018
3 Reads

Unedited microneurosurgery of a mixed germ cell tumor of the pineal region.

Surg Neurol Int 2018 24;9:262. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Germ cell tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell tumors based on clinicopathological features. The nongerminomatous group of tumors includes embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell tumors with more than one element. While germinomas are radiation-sensitive tumors, all other tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and tumor-free survival rates. Read More

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http://dx.doi.org/10.4103/sni.sni_357_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322164PMC
December 2018
1 Read

Comparing Serum and Salivary Levels of Vitamin D in Patients with Recurrent Aphthous Stomatitis and Healthy Individuals.

J Dent (Shiraz) 2018 Dec;19(4):295-300

Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa. Many studies have emphasized on immunologic factors as the reason of inducing RAS; however, the exact etiologic cause of RAS has not been identified yet. Vitamin D has an endocrine function and regulatory effects on the immune system. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338692PMC
December 2018
6 Reads

Should we regard all main duct type intraductal papillary mucinous neoplasms of the pancreas (MD-IPMN) as an indication of surgery? -A retrospective study in 29 patients with MD-IPMN showing mural nodules.

Pancreatology 2019 Jan 11. Epub 2019 Jan 11.

Department of Gastroenterology, Sendai City Medical Center, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Purpose: To elucidate predictive factors for malignant main duct type IPMN (MD-IPMN).

Methods: All 29 subjects had mural nodules (MNs) in the main pancreatic duct (MPD) on preoperative endoscopic ultrasonography and underwent surgery (19, malignant; 10, benign). Possible predictive factors for malignancy such as background, imaging, and histological factors including histological subtype (HS), were evaluated. Read More

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http://dx.doi.org/10.1016/j.pan.2019.01.005DOI Listing
January 2019

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report.

Oncol Lett 2019 Feb 28;17(2):1969-1973. Epub 2018 Nov 28.

Department of Orthopedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develops within the tubular bone. While giant cell tumor of the tendon sheath or enchondroma are common benign soft tissue and bone tumors, respectively the simultaneous occurrence of these tumors in the same region of the hand is exceedingly rare, and it can mimic a malignant tumor, thereby making the diagnosis more challenging. Read More

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http://dx.doi.org/10.3892/ol.2018.9775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341555PMC
February 2019

Microsatellite Instability Predicts Response to Anti-PD1 Immunotherapy in Metastatic Melanoma.

Authors:
Luca Roncati

Acta Dermatovenerol Croat 2018 Dec;26(4):341-343

Dr. Luca Roncati, MD, PhD, Department of Medical and Surgical Sciences Institute of Pathology, University Hospital of Modena, Policlinico, I-41124 Modena (MO), Italy;

Dear Editor, Immune-checkpoint blockade is a type of passive immunotherapy aimed at enhancing preexisting anti-tumor responses of the organism, blocking self-tolerance molecular interactions between T-lymphocytes and neoplastic cells (1,2). Despite a significant increase in progression-free survival, a large proportion of patients affected by metastatic melanoma do not show durable responses even after appropriate diagnostic categorization and shared therapeutic choices (3-9). Therefore, predictive biomarkers of clinical response are urgently needed, and predictive immunohistochemistry (IHC) meets these requirements. Read More

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December 2018
12 Reads

Analysis of uterine corporeal mesenchymal tumors occurring after menopause.

BMC Womens Health 2019 Jan 18;19(1):13. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555, Japan.

Objective: Because it is difficult to diagnose accurately whether uterine corporeal mesenchymal tumors are benign or malignant before surgery, an understanding of the characteristics of patients with uterine sarcomas occurring in the postmenopausal period is required.

Methods: We retrospectively reviewed the cases of women who underwent surgery for uterine mesenchymal tumors at our hospital.

Results: Among 487 operated cases, 447 tumors occurred in the premenopausal period and 40 occurred in the postmenopausal period. Read More

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http://dx.doi.org/10.1186/s12905-019-0714-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339291PMC
January 2019
2 Reads

Novel Treatment of a Malignant Peripheral Nerve Sheath Tumor of the Median Nerve.

Plast Reconstr Surg Glob Open 2018 Dec 14;6(12):e2011. Epub 2018 Dec 14.

Department of Plastic, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus Lübeck, Germany.

Malignant peripheral nerve sheath tumors are rare, associated with a poor prognosis and uncertainty regarding the appropriate management. We report a novel oncologic and reconstructive treatment of a young patient with a malignant peripheral nerve sheath tumor of the median nerve of the left hand. The patient underwent a wide local excision, an opponensplasty, a nerve reconstruction by nerve allografts followed by brachytherapy treatment. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326595PMC
December 2018
4 Reads

Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials.

Drug Des Devel Ther 2019 28;13:183-203. Epub 2018 Dec 28.

Department of Radiotherapy, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong Province, China,

Objective: To systematically evaluate the efficacy and safety of sodium cantharidinate and vitamin B6 (SC/B6) combined with conventional medical treatment (CMT) for the treatment of patients with advanced digestive system neoplasms (DSNs).

Methods: The Cochrane Library, Embase, PubMed, Web of Science, Chinese Scientific Journal Database (VIP), China National Knowledge Infrastructure, and Wanfang databases were searched for clinical trials using SC/B6 for DSNs. Outcome measures, including therapeutic efficacy, quality of life (QoL), and adverse events, were extracted and systematically evaluated. Read More

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https://www.dovepress.com/efficacy-and-safety-of-sodium-cant
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http://dx.doi.org/10.2147/DDDT.S190674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312696PMC
December 2018
6 Reads

Human papilloma virus identification in ocular surface squamous neoplasia by p16 immunohistochemistry and DNA chip test: A strobe-compliant article.

Medicine (Baltimore) 2019 Jan;98(2):e13944

Department of Ophthalmology and Research Institute of Medical Sciences.

The aim of this study was to identify the association between human papilloma virus (HPV) infection and ocular surface squamous neoplasia (OSSN) using p16 immunohistochemistry (IHC) and deoxyribonucleic acid (DNA) chip test.Thirty-eight patients who underwent surgical excision of OSSN were retrospectively studied using tissue samples. The IHC was performed to assess the expression of p16 and DNA chip test was used to detect 24 HPV serotypes. Read More

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http://dx.doi.org/10.1097/MD.0000000000013944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336645PMC
January 2019

Galectin-3 regulates chemotherapy sensitivity in epithelial ovarian carcinoma via regulating mitochondrial function.

J Toxicol Sci 2019 ;44(1):47-56

Department of Obstetrics, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, China.

Galectin-3 (Gal-3) is a multifunctional carbohydrate-binding protein associated with cell migration, cell proliferation, cell adhesion, and cell-cell interaction in tumor cells. It has been implied to be involved in the tumor progression and chemoresistance of epithelial ovarian cancer (EOC). However, it is unclear whether the Gal-3-mediated regulation on the EOC chemosensitivity is associated with hypoxia or mitochondrial dysfunction. Read More

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https://www.jstage.jst.go.jp/article/jts/44/1/44_47/_article
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http://dx.doi.org/10.2131/jts.44.47DOI Listing
January 2019
3 Reads
1.378 Impact Factor

Minimally Invasive Ivor Lewis Esophagectomy Without Patient Repositioning.

J Gastrointest Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Surgery, Division of Surgical Oncology, Carolinas Medical Center, Levine Cancer Institute, 1021 Morehead Medical Drive #6100, Charlotte, NC, 28204, USA.

Introduction: The standard technique for Ivor Lewis minimally invasive esophagectomy involves a two-stage approach necessitating repositioning mid-procedure.

Technique: We describe our technique for a one-stage hand-assisted minimally invasive esophagectomy that allows sequential access to the chest and abdomen within the same surgical field, eliminating the need for repositioning. The patient is positioned in a "corkscrew" configuration with the abdomen supine and the chest rotated to the left to allow access to the right chest. Read More

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http://dx.doi.org/10.1007/s11605-018-4063-8DOI Listing
January 2019
1 Read

Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.

Authors:
E V Kochurova

Bull Exp Biol Med 2019 Jan 8;166(3):383-385. Epub 2019 Jan 8.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow, Russia.

The benign and malignant neoplasms in parotid gland have similar clinical presentations despite different tumor growth rates. The study compared the clinical and morphological data as well as the results of ELISA for MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in salivary fluid yielded during primary examination of the patients with pleomorphic adenoma and adenocarcinoma of parotid gland. The examined biomarkers detected in salivary fluid in patients with various cancer types differed significantly (p≤0. Read More

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http://dx.doi.org/10.1007/s10517-019-04355-wDOI Listing
January 2019
1 Read

Apatinib with EGFR-TKIs in advanced wild gene-type NSCLC: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13924

Department of Oncology, Xinjin County People's Hospital.

Rationale: For advanced non-small-cell lung cancer (NSCLC), targeted therapy and chemoradiotherapy are recommended as the first-line treatment. For patients with a performance status (PS) score over 2 and without gene mutation, however, only supportive treatment is provided and survival time is extremely short. We believe that more can be done to improve the patient's survival time and their quality of life. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0004
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http://dx.doi.org/10.1097/MD.0000000000013924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344168PMC
January 2019
12 Reads

Discovery of a novel dipeptidyl boronic acid proteasome inhibitor for the treatment of multiple myeloma and triple-negative breast cancer.

Org Biomol Chem 2019 01;17(3):683-691

College of Science, Nanjing Forestry University, No. 159 Longpan Road, Nanjing 210037, PR China.

A series of novel dipeptidyl boronic acid compounds were designed, synthesized and biologically investigated for the inhibition of the β5 subunit of 20S proteasome and several compounds showed high activities with IC50 values of less than 10 nM. Some of these compounds potently inhibited the multiple myeloma (MM) cancer cell lines with IC50 values of less than 10 nM. It was reported that the inhibition of both β2 and β5 subunits strongly increased the cytotoxicity of proteasome inhibitors in solid tumor cells, so some of the compounds were evaluated for the inhibition of the β2 subunit and the solid tumor triple-negative breast cancer cell line MDA-MB-231. Read More

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http://dx.doi.org/10.1039/c8ob02668hDOI Listing
January 2019
3.562 Impact Factor

ARF influences diabetes through promoting the proliferation and malignant development of β cells.

Artif Cells Nanomed Biotechnol 2019 Jan 2:1-5. Epub 2019 Jan 2.

a The First Hospital and Institute of Immunology, Jilin University , Changchun , China.

Objective: Diabetes is a common chronic disease. ARF is a new tumor suppressor, which is one hotspot of cell cycle regulators. The mutation of ARF is absent in nearly 50% of tumors. Read More

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http://dx.doi.org/10.1080/21691401.2018.1505750DOI Listing
January 2019

Automated diagnosis of breast ultrasonography images using deep neural networks.

Med Image Anal 2019 Feb 20;52:185-198. Epub 2018 Dec 20.

Machine Intelligence Laboratory, College of Computer Science, Sichuan University, Chengdu, 610065, PR China. Electronic address:

Ultrasonography images of breast mass aid in the detection and diagnosis of breast cancer. Manually analyzing ultrasonography images is time-consuming, exhausting and subjective. Automated analyzing such images is desired. Read More

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http://dx.doi.org/10.1016/j.media.2018.12.006DOI Listing
February 2019
3.654 Impact Factor

Vitiligo-like lesions in a patient treated with nivolumab for renal cell carcinoma.

Medicine (Baltimore) 2018 Dec;97(52):e13810

Skin Cancer Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola.

Rationale: The introduction of immune check-point inhibitors (ICIs) in the treatment of solid neoplasms is associated with the need to know and manage a new type of side effects that are commonly defined immune-mediated adverse events. Dermatologic immune-mediated adverse events are relatively common. Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs in particular in patients with malignant melanoma, probably due to a common autoimmune mechanism against both melanoma cells and normal melanocytes. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
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http://dx.doi.org/10.1097/MD.0000000000013810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314787PMC
December 2018
3 Reads

The cubital tunnel syndrome caused by intraneural ganglion cyst of the ulnar nerve at the elbow: a case report.

BMC Neurol 2018 Dec 22;18(1):217. Epub 2018 Dec 22.

Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, People's Republic of China.

Background: Cubital tunnel syndrome is common nerve compression syndrome among peripheral nerve compression diseases. However, the syndrome caused by intraneural ganglion cysts has been rarely reported. Medical approaches, like ultrasound-guided aspiration and open surgical treatment remain to be discussed. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1229-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303969PMC
December 2018
7 Reads

Colloid Osmotic Pressure Participates on the Post-transplant Lymphocele Pathogenesis.

Transplant Proc 2018 Dec 30;50(10):3422-3425. Epub 2018 Jun 30.

Department of Urology, University Hospital, Hradec Kralove, Czech Republic; Faculty of Medicine in Hradec Kralove, Department of Surgery, Charles University, Hradec Kralove, Czech Republic.

The aim of the study was to evaluate the role of colloid osmotic pressure in post-transplant lymphocele pathogenesis. We have analyzed total plasmatic protein and albumin levels, and electrophoresis has been completed in blood samples before transplantation and in days 3 and 14 after transplantation in 50 patients with lymphocele (Lymphocele) and 198 patients without lymphocele (control), respectively. Colloid osmotic pressure (COP) was calculated according to the Hoefs formula. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.043DOI Listing
December 2018

A phase 2 trial of regorafenib as a single agent in patients with chemotherapy-refractory, advanced, and metastatic biliary tract adenocarcinoma.

Cancer 2018 Dec 18. Epub 2018 Dec 18.

National Institute for Occupational Safety and Health (NIOSH) Research Branch, Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania.

Background: Biliary tract cancers are rare, aggressive neoplasms. Most patients present with advanced/unresectable or metastatic disease at diagnosis, and no second-line regimen has demonstrated clinical benefit. This was a phase 2 study evaluating the efficacy and safety of regorafenib in patients who had advanced/unresectable or metastatic disease after receiving standard therapy. Read More

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http://dx.doi.org/10.1002/cncr.31872DOI Listing
December 2018
1 Read

IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas.

Medicine (Baltimore) 2018 Dec;97(50):e13675

Department of Neurosurgery.

Glioma is the most common malignant tumor in the central nervous system (CNS). Lower-grade gliomas (LGG) refer to Grade II and III gliomas. In LGG patients, seizure often appears as an initial symptom and play an important role in clinical performance and quality of life of the patients. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812140-0011
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http://dx.doi.org/10.1097/MD.0000000000013675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320119PMC
December 2018
1 Read
5.723 Impact Factor

Clinical efficacy and safety of apatinib in patients with advanced colorectal cancer as the late-line treatment.

Medicine (Baltimore) 2018 Dec;97(50):e13635

Department of First Chemotherapy.

There is currently no standard therapeutic regimen available for patients with advanced colorectal cancer in whom the disease continues to progress after 2 or more lines of chemotherapy. The purpose of this study is to investigate the efficacy and safety of apatinib in patients with advanced colorectal cancer for whom at least two lines of prior chemotherapy had failed.Twenty seven patients with advanced colorectal cancer who had failed at least 2 lines chemotherapy were treated with apatinib (500 mg/day). Read More

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http://Insights.ovid.com/crossref?an=00005792-201812140-0009
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http://dx.doi.org/10.1097/MD.0000000000013635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320137PMC
December 2018
10 Reads
5.723 Impact Factor

Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A.

Ecotoxicol Environ Saf 2019 Apr 14;170:495-501. Epub 2018 Dec 14.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Halogenated bisphenol A analogues (X-BPA) have been widely used in industrial production, such as flame retardant. Although BPA exposure was found to result in cytotoxicity, toxicity of X-BPA and molecular mechanism remain under-explored. In this study, we employed human breast cancer cell as a model to investigate the concentration-dependent toxicity and underlying mechanisms of tetrabromo bisphenol A (TBBPA) and tetrachloro bisphenol A (TCBPA). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.018DOI Listing
April 2019
2 Reads

Hepatic arterial therapy with oxaliplatin and systemic capecitabine for patients with liver metastases from breast cancer.

Breast 2019 Feb 5;43:113-119. Epub 2018 Dec 5.

Department of Oncology, Herlev & Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark.

Objectives: Hepatic arterial treatment (HAT) for liver metastases in patients with metastatic breast cancer (MBC) has only been investigated in few studies.

Materials And Methods: Two phase II trials were initiated simultaneously to evaluate capecitabine in combination with oxaliplatin in patients with MBC and liver metastases. These two trials are reported together. Read More

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http://dx.doi.org/10.1016/j.breast.2018.12.002DOI Listing
February 2019

The treatment results in patients with lmphoma disease in the orbit.

Cesk Slov Oftalmol 2018 ;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

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January 2018
2 Reads

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.

PLoS Comput Biol 2018 12 7;14(12):e1006584. Epub 2018 Dec 7.

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America.

Cancer metabolism has received renewed interest as a potential target for cancer therapy. In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg effect, the reverse Warburg effect and glutamine addiction. At the intracellular level, we construct a network of central metabolism and perform flux balance analysis (FBA) to estimate metabolic fluxes; at the cellular level, we exploit this metabolic network to calculate parameters for a coarse-grained description of cellular growth kinetics; and at the multicellular level, we incorporate these kinetic schemes into the cellular automata of an agent-based model (ABM), iDynoMiCS. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6285468PMC
December 2018
10 Reads

OPTIC DISK ASTROCYTOMA UNASSOCIATED WITH TUBEROUS SCLEROSIS COMPLEX MANAGED WITH SURGICAL EXCISION AND A 7-YEAR FOLLOW-UP.

Authors:
Yao Lu Yimin Xu

Retin Cases Brief Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Ministry of Education, Key Laboratory of Vision Loss and Restoration, Peking University Third Hospital, Beijing, China.

Purpose: Optic disk astrocytoma is a rare variant of congenital hamartoma, which is usually associated with tuberous sclerosis complex. Generally, it is stationary but in rare cases, it can show progressive growth and cause severe local complications.

Methods: Clinical-pathologic correlation. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000821DOI Listing
November 2018

Leishmania infection: Misdiagnosis as cancer and tumor-promoting potential.

Acta Trop 2018 Dec 7. Epub 2018 Dec 7.

Université Côte d'Azur, Inserm, C3M, Nice Cedex 3, France. Electronic address:

Given the prevalence of cancer and leishmaniasis worldwide, the presence of these two pathologies in the same tissue sample may be merely fortuitous. The clinical outcome of both diseases is under the control of innate and adaptive immunity, and in both cases these progressive diseases are characterized by an impaired host Th1 response. As a consequence, the Th2 cytokine microenvironment occurring in progressive leishmaniasis may potentially promote tumor cell proliferation and vice versa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183132
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http://dx.doi.org/10.1016/j.actatropica.2018.12.010DOI Listing
December 2018
23 Reads

Quantification of Thiopurine Nucleotides in Erythrocytes and Clinical Application to Pediatric Acute Lymphoblastic Leukemia.

Ther Drug Monit 2019 02;41(1):75-85

Department of Laboratory Medicine, Seoul National University College of Medicine.

Background: Concentrations of 6-thioguanine (6TG) nucleotides and 6-methylmercaptopurine (6MMP) nucleotides in RBCs were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This assay was validated for clinical use and was applied to blood samples from patients taking mercaptopurine (6MP).

Methods: RBCs were hemolyzed and deproteinized using perchloric acid, followed by heating for the hydrolysis of nucleotides, and the resultant base was measured using LC-MS/MS. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000575DOI Listing
February 2019
2 Reads

Ischemic Complications After High-Grade Glioma Resection Could Interfere With Residual Tumor Detection With 18F-Fluorocholine PET/CT.

Clin Nucl Med 2019 Feb;44(2):e76-e84

From the Departments of Nuclear Medicine.

Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT. On the other hand, hypoxia caused by ischemia promotes invasive glioma growth. We present 3 cases of patients with different grades of ischemic injury after resection of high-grade glioma. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9733
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http://dx.doi.org/10.1097/RLU.0000000000002392DOI Listing
February 2019
7 Reads

Efficacy, safety, and prognostic indicators of first-line sunitinib in patients with metastatic renal cell carcinoma: A single center experience.

J Cancer Res Ther 2018 Oct-Dec;14(6):1303-1311

Department of Clinical Oncology, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Background: We assessed the efficacy and safety of sunitinib as the first-line treatment in metastatic renal cell carcinoma (mRCC) patients. The predictors of survival and efficacy in mRCC as identified from previous studies, including the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic RCC Database Consortium (IMDC) factors, were also evaluated.

Patients And Methods: Data from 56 patients with mRCC, treated with sunitinib at our institute (2006-2014), were analyzed retrospectively. Read More

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http://dx.doi.org/10.4103/0973-1482.189247DOI Listing
February 2019
1 Read

[Major neurological complications of genitourinary cancers].

Rev Neurol 2018 Dec;67(11):441-452

Universidad Complutense de Madrid. Facultad de Medicina, 28040 Madrid, Espana.

Introduction: Genitourinary cancers constitute a heterogeneous and increasingly frequent group of malignant tumors that have the potential to derive directly, or indirectly from the treatment applied, in a series of neurological complications that negatively impact on the quality of life of the patients who suffer them.

Aims: To report the most relevant data on the main neurological complications of genitourinary cancers.

Development: We conducted a PubMed search for articles, latest books, leading clinical practice guidelines, and scientific societies, regarding the appearance of such complications. Read More

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December 2018
10 Reads

[CME: Paraneoplastic Endocrine Syndromes].

Authors:
Christoph Henzen

Praxis (Bern 1994) 2018 Nov;107(24):1309-1315

1 Innere Medizin/Endokrinologie und Diabetologie, Luzerner Kantonsspital.

CME: Paraneoplastic Endocrine Syndromes Abstract. Paraneoplastic endocrine syndromes are caused by ectopic hormone production by malignant tumor cells. Knowledge of paraneoplastic endocrine syndromes may allow a timely diagnosis of the underlying cancer at a treatable stage and, on the other hand, appropriate treatment of the endocrine manifestations reduces morbidity and mortality of the affected patients. Read More

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https://econtent.hogrefe.com/doi/10.1024/1661-8157/a003132
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http://dx.doi.org/10.1024/1661-8157/a003132DOI Listing
November 2018
10 Reads

Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182.

Cell Physiol Biochem 2018 27;51(3):1149-1163. Epub 2018 Nov 27.

Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun,

Background/aims: Previous studies demonstrated the oncogenic roles of lncRNA UCA1 in osteosarcoma. This study aimed to explore the internal molecular mechanism of UCA1 on promoting osteosarcoma cell proliferation, migration and invasion.

Methods: qRT-PCR was conducted to measure the expression levels of UCA1, miR-182 and TIMP2. Read More

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https://www.karger.com/Article/FullText/495493
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http://dx.doi.org/10.1159/000495493DOI Listing
January 2019
7 Reads

CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer.

World J Gastroenterol 2018 Nov;24(42):4738-4749

Program Against Cancer Therapeutic Resistance, Catalan Institute of Oncology, Germans Trias i Pujol health research institute, Badalona, Barcelona 08916, Catalunya, Spain.

Colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women, worldwide. In the early stages of the disease, biomarkers predicting early relapse would improve survival rates. In metastatic patients, the use of predictive biomarkers could potentially result in more personalized treatments and better outcomes. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i42/4738.htm
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http://dx.doi.org/10.3748/wjg.v24.i42.4738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235799PMC
November 2018
6 Reads

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence.

Proc Natl Acad Sci U S A 2018 12 26;115(50):E11661-E11670. Epub 2018 Nov 26.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China;

Long noncoding RNAs (lncRNAs) function through a diverse array of mechanisms that are not presently fully understood. Here, we sought to find lncRNAs differentially regulated in cancer cells resistant to either TNF-related apoptosis-inducing ligand (TRAIL) or the Mcl-1 inhibitor UMI-77, agents that act through the extrinsic and intrinsic apoptotic pathways, respectively. This work identified a commonly up-regulated lncRNA, ovarian adenocarcinoma-amplified lncRNA (OVAAL), that conferred apoptotic resistance in multiple cancer types. Read More

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http://dx.doi.org/10.1073/pnas.1805950115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294934PMC
December 2018
1 Read
9.809 Impact Factor

Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.

Pathology 2019 Jan 20;51(1):62-66. Epub 2018 Nov 20.

Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Teratomas show diverse biologic behaviour and prognosis as well as variable histological features. Importantly, post-pubertal testicular teratomas composed of mature components have a potential for malignant behaviour, in contrast to ovarian dermoid cysts and pre-pubertal testicular teratomas which are considered almost always benign. On the other hand, the biological behaviour and histogenesis of extragonadal teratomas are still not fully elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00313025183021
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http://dx.doi.org/10.1016/j.pathol.2018.10.002DOI Listing
January 2019
14 Reads

Dosimetric comparison of different radiation techniques (IMRT vs. 3-dimensional) of the "true" (deep) ano-inguinal lymphatic drainage of anal cancer patients.

Radiat Oncol 2018 Nov 22;13(1):227. Epub 2018 Nov 22.

Department of Radiation Oncology, Klinikum rechts der Isar, TU München, Ismaninger Str. 22, 81675, Munich, Germany.

Introduction: The ano-inguinal lymphatic drainage (AILD) is located in the subcutaneous adipose tissue of the proximal medial thigh. Currently, there are no recommendations for an inclusion of the 'true' AILD in the clinical target volume (CTV) of definitive chemoradiation for anal cancer patients. To estimate the relevance of inguinal recurrence, we compared the incidental dose to the AILD in anal cancer (AC) patients who were treated either with Volumetric Arc Therapy - Intensity Modulated Radiation Therapy (VMAT-IMRT) or conventional 3D-radiation technique. Read More

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http://dx.doi.org/10.1186/s13014-018-1174-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249729PMC
November 2018
8 Reads

The combination of apatinib and S-1 for the treatment of advanced gastric cancer in China: A meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2018 Nov;97(47):e13259

Department of Gastroenterology, Weifang People's Hospital.

Background: Apatinib-targeted therapy is considered a promising treatment option for malignancies. This study systematically evaluated the efficacy and safety of the combination of apatinib and S-1 for the treatment of patients with advanced gastric cancer (GC).

Methods: Clinical trials were searched from the PubMed, Cochrane Library, Embase, CNKI, and Wanfang databases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013259DOI Listing
November 2018
14 Reads

Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells.

Int J Mol Sci 2018 Nov 16;19(11). Epub 2018 Nov 16.

Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 300041 Timişoara, Romania.

Chamomile, parsley, and celery represent major botanical sources of apigenin, a well-known flavone with chemopreventive properties. The aim of this study was to assess the phytochemical composition, antioxidant, and anti-inflammatory potential of methanol extracts obtained from chamomile, parsley, and celery collected from Romania, as well as the biological activity against A375 human melanoma and human dendritic cells. Results have shown that all three extracts are rich in polyphenolic compounds and flavonoids, and they generate a radical scavenger capacity, iron chelation potential, as well as lipoxygenase inhibition capacity. Read More

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http://www.mdpi.com/1422-0067/19/11/3624
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http://dx.doi.org/10.3390/ijms19113624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274727PMC
November 2018
8 Reads

The prognostic value of the systemic inflammatory response in randomised clinical trials in cancer: A systematic review.

Crit Rev Oncol Hematol 2018 Dec 5;132:130-137. Epub 2018 Oct 5.

Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.

Background: The prognostic value of the systemic inflammatory response in cancer has been well established in observational studies. This review aims to examine and rationalise the evidence for the role of systemic inflammation based prognostic scores in randomised clinical trials.

Method: An extensive literature review using targeted medical subject headings was carried out in the MEDLINE, EMBASE, and CDSR databases until January 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428183017
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http://dx.doi.org/10.1016/j.critrevonc.2018.09.016DOI Listing
December 2018
7 Reads