42,342 results match your criteria Hand Malignant Tumors


Reliability of automated versus handheld breast ultrasound examinations of suspicious breast masses.

Ultrasonography 2018 Dec 23. Epub 2018 Dec 23.

Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: The purpose of this study was to assess the reliability of automated breast ultrasound (ABUS) examinations of suspicious breast masses in comparison to handheld breast ultrasound (HHUS) with regard to Breast Imaging Reporting and Data System (BI-RADS) category assessment, and to investigate the factors affecting discrepancies in categorization.

Methods: A total of 135 masses that were assessed as BI-RADS categories 4 and 5 on ABUS that underwent ultrasound (US)-guided core needle biopsy from May 2017 to December 2017 were included in this study. The BI-RADS categories were re-assessed using HHUS. Read More

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http://dx.doi.org/10.14366/usg.18055DOI Listing
December 2018

A Comparative Study for Selectivity of Micronuclei in Cervical Exfoliated Cells on Chronic Boron Effects.

J Cytol 2019 Apr-Jun;36(2):75-78

Department of Medical Biology, School of Medicine, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkey.

Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer.

Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Read More

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http://dx.doi.org/10.4103/JOC.JOC_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425774PMC
April 2019
1 Read

Evaluating the trend of cutaneous malignant tumors in Ilam from 2002 to 2011.

J Family Med Prim Care 2019 Feb;8(2):717-721

Department of Cardiology, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Skin cancer, the melanoma type of which causes high mortality, is the most common malignancy in Iran and all over the world. UV is the most important cause of the incidence of this disease. This study evaluates the frequency of different types of cancer and their trajectory in Ilam province from 2012 to 2011. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_178_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436317PMC
February 2019
3 Reads

The expression of Platelet-Derived Growth Factor Receptors (PDGFRs) and their correlation with overall survival of patients with ovarian cancer.

Ginekol Pol 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, Poland.

Objectives: The main aim of the study was to investigate the expression of Platelet-Derived Growth Factor Receptors alpha (PDGFR-alpha) and beta (PDGFR-beta) in malignant and benign ovarian tumors. We performed an analysis of the correlation of PDGFRs expression and stage of the disease, tumor grade and histopathological type of epithelial ovarian cancer (EOC). Additionally, we evaluated patient prognosis according to PDGFR expression. Read More

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http://dx.doi.org/10.5603/GP.a2019.0045DOI Listing
April 2019
3 Reads

Frequent attenders at risk of disability pension: a longitudinal study combining routine and register data.

Scand J Public Health 2019 Apr 11:1403494819838663. Epub 2019 Apr 11.

1 Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

Aims: Frequent attendance in healthcare services is associated with ill-health and chronic illnesses. More information is needed about the phenomenon's connection with disability pensions (DPs).

Methods: The study group comprised 59,676 patients divided into occasional- (1yFAs) and persistent frequent attenders (pFAs) and non-frequent attenders (non-FAs). Read More

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http://dx.doi.org/10.1177/1403494819838663DOI Listing
April 2019
1 Read

MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7.

Biosci Biotechnol Biochem 2019 Apr 11:1-10. Epub 2019 Apr 11.

e Department of Neurosurgery , Weifang People's Hospital , Weifang , P. R. China.

Pituitary adenomas (PA) are commonly occurring benign neoplasms. Identification of molecular pathway resulting in pituitary tumorigenesis remains challenges in endocrine oncology. The present study was conducted with aim of investigating the role of microRNA-543 (miR-543) in PA development. Read More

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http://dx.doi.org/10.1080/09168451.2019.1591260DOI Listing
April 2019
1 Read

Minimally invasive resection of posterosuperior liver tumors in the supine position using intra-abdominal trocars.

Surg Endosc 2019 Apr 8. Epub 2019 Apr 8.

Department of Endocrine Surgery, Cleveland Clinic, 9500 Euclid Ave/F20, Cleveland, OH, 44195, USA.

Background: Laparoscopic liver resection (LLR) of posterosuperior (PS) segment liver tumors is technically challenging with confusion about optimal patient positioning and trocar placement (i.e., transabdominal vs. Read More

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http://dx.doi.org/10.1007/s00464-019-06789-9DOI Listing

The metabolic milieu in melanoma: Role of immune suppression by CD73/adenosine.

Tumour Biol 2019 Apr;42(4):1010428319837138

Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy.

The mechanisms leading to immune escape of melanoma have been largely investigated in relation to its tumour immunogenicity and features of inflamed microenvironment that promote the immune suppression during the disease progression. These findings have recently led to advantages in terms of immunotherapy-based approaches as rationale for overcoming the immune escape. However, besides immune checkpoints, other mechanisms including the adenosine produced by ectonucleotidases CD39 and CD73 contribute to the melanoma progression due to the immunosuppression induced by the tumour milieu. Read More

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http://dx.doi.org/10.1177/1010428319837138DOI Listing

Extracorporeal Irradiation and Reimplantation of Tumor-bearing Bone Segments Following Diaphyseal Sarcoma Resection at the Tibia.

Anticancer Res 2019 Apr;39(4):2015-2023

Department of Plastic and Hand Surgery, University Hospital, Basel, Switzerland.

Background/aim: Reconstruction of diaphyseal tibial sarcomas with extracorporeal irradiated autograft is a rarely applied technique and is analyzed in this study.

Patients And Methods: Eight patients with malignant sarcomas received local treatment by means of a wide resection and reimplantation of an extracorporeally-irradiated autograft. The graft was combined with an ipsilateral vascularized fibula when a full-thickness segment of the tibia had to be resected and no cortex could be preserved (n=5). Read More

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http://dx.doi.org/10.21873/anticanres.13312DOI Listing

Usefulness of Inferior Vena Cava Filters in Stable Patients with Acute Pulmonary Embolism.

Am J Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.

Retrospective cohort studies using administrative data from national databases or a registry suggest that there are subcategories of stable patients with acute pulmonary embolism who would show a reduced mortality with an inferior vena cava (IVC) filter in addition to anticoagulants. These subcategories are those who underwent pulmonary embolectomy, receiving thrombolytic therapy, suffering recurrent pulmonary embolism while on treatment, hospitalized with solid malignant tumors if aged >60years, hospitalized with chronic obstructive pulmonary disease (COPD) if aged >50years, and very elderly (aged >80 years). The following is a review of these studies. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.054DOI Listing
March 2019
2 Reads

Iso- or hyperintensity of hepatocellular adenomas on hepatobiliary phase does not always correspond to hepatospecific contrast-agent uptake: importance for tumor subtyping.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiology, APHP, HU Henri Mondor, Creteil, Val-de-Marne, France.

Purpose: This study was conducted in order to evaluate if iso- or hyperintensity of HCAs on HBP is systematically related to a high uptake of hepatospecific contrast agent, using a quantitative approach.

Methods: This bicentric retrospective study included all patients with histologically confirmed and subtyped HCA from 2009 to 2017 who underwent MRI with HBP after Gd-BOPTA injection and who showed iso- or hyperintensity on HBP. The signal intensity of tumors on pre- and postcontrast images and the presence of hepatic steatosis were noted. Read More

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http://dx.doi.org/10.1007/s00330-019-06150-7DOI Listing
April 2019
3 Reads

Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress.

Free Radic Biol Med 2019 Mar 28;136:52-59. Epub 2019 Mar 28.

Department of Molecular and Internal Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. Electronic address:

Purpose: Although radiotherapy is important in the treatment of malignant thoracic tumors, it has harmful effects on healthy tissues. We previously showed that suplatast tosilate, an anti-allergic agent, scavenged reactive oxygen species (ROS), including hydroxyl radicals. Because ROS-mediated oxidative stress is involved in radiation-induced lung injury, we hypothesized that suplatast tosilate could reduce radiation-induced lung injury via suppression of oxidative stress. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.024DOI Listing
March 2019
1 Read

The role of ASXL1 in hematopoiesis and myeloid malignancies.

Cell Mol Life Sci 2019 Mar 30. Epub 2019 Mar 30.

Division of Cellular Therapy, Advanced Clinical Research Center, and Division of Stem Cell Signaling, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 1088639, Japan.

Recent high-throughput genome-wide sequencing studies have identified recurrent somatic mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 (ASXL1), is one of the most frequently mutated genes in all subtypes of myeloid malignancies. ASXL1 mutations are also frequently detected in clonal hematopoiesis, which is associated with an increased risk of mortality. Read More

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http://dx.doi.org/10.1007/s00018-019-03084-7DOI Listing
March 2019
2 Reads

Robotic radical lymphadenectomy without touching the pancreas during gastrectomy for gastric cancer.

Medicine (Baltimore) 2019 Mar;98(13):e15091

Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.

Laparoscopic lymph node dissection around the peripancreatic area for gastric cancer (GC) remains challenging because of drawbacks in laparoscopic surgery including the limited range of movement, amplification of hand tremors, and inconvenient surgical positioning. In some cases of laparoscopic gastrectomy (LG), therefore, postoperative pancreatic fistula (POPF) occurs. Robotic surgery, on the other hand, plays an essential role in ergonomics and offers advantages, such as motion scaling, less fatigue, tremor filtering, 7 degrees of motion in the robotic instruments assisted by the wrist-like instruments tips, and three-dimensional vision. Read More

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http://dx.doi.org/10.1097/MD.0000000000015091DOI Listing
March 2019
1 Read

[Testicular germ cell tumors: Histopathological and molecular features].

Bull Cancer 2019 Apr 21;106(4):328-341. Epub 2019 Mar 21.

Hôpital Foch, service d'anatomie et cytologie pathologiques, 40, rue Worth, 92150 Suresnes, France; Institut Curie, service de pathologie, 35, rue Dailly, 92240 Saint Cloud, France. Electronic address:

In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on the other hand, postpubertal-type tumors, GCNIS-derived, which occur in youg men (seminoma and non seminomatous germ cell tumors - embryonal carcinoma, yolk sac tumor, teratoma and choriocarcinoma essentially). The term germ cell neoplasia in situ is consensually accepted as a new terminology for the precursor lesion. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.02.004DOI Listing
April 2019
1 Read

Multi-target compounds acting in cancer progression: Focus on thiosemicarbazone, thiazole and thiazolidinone analogues.

Eur J Med Chem 2019 May 14;170:237-260. Epub 2019 Mar 14.

Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil. Electronic address:

Currently, cancer and its progression to metastasis result in a large number of deaths. The lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete understanding of the molecular machinery are the major obstacles in metastasis prevention and treatment. On the other hand, thiosemicarbazones and their bioisosteres, thiazole and thiazolidinone are recurring in a wide range of biologically active compounds that reach different targets within tumor context and represent a promising start point to access potential candidates in metastatic cancer. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.024DOI Listing

Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma.

Nat Commun 2019 03 22;10(1):1353. Epub 2019 Mar 22.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures in both LPS tissues and cell lines. We identify a bromodomain and extraterminal (BET) protein-cooperated FUS-DDIT3 function in myxoid LPS and a BET protein-dependent core transcriptional regulatory circuitry consisting of FOSL2, MYC, and RUNX1 in de-differentiated LPS. Read More

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http://dx.doi.org/10.1038/s41467-019-09257-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430783PMC
March 2019
1 Read

Preoperative colonoscopy in patients with a supposed primary ovarian cancer.

Medicine (Baltimore) 2019 Mar;98(12):e14929

Medical Faculty, University of Rzeszow.

The final diagnosis of ovarian cancer is based on surgery and pathological verification. Therefore patients who are presented to surgery may be described only as supposed ovarian cancer. According to the literature the diagnosis of ovarian cancer is confirmed only in 2/3 of them. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903220-0004
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http://dx.doi.org/10.1097/MD.0000000000014929DOI Listing
March 2019
5 Reads

A case report for severe hand-foot skin reaction caused by chemotherapy with actinomycin D in a patient with oculocutaneous albinism.

Onco Targets Ther 2019 8;12:1851-1855. Epub 2019 Mar 8.

Department of Obstetrics and Gynecology, The First Affiliated Hospital, Anhui Medical University, Hefei 230020, Anhui, P.R. China,

Gestational trophoblastic neoplasms (GTN) are highly curable tumors, with an overall patient survival of 90%, due to the individualized chemotherapy. However, chemotherapy regimens vary between different treatment centers and the comparable benefits and risks of these different regimens are unclear. Here, we reported a case of GTN with oculocutaneous albinism (OCA) is resistant to fluorouracil (5-FU), extremely sensitive to actinomycin D (Act-D) with severe hand-foot skin reaction (HFSR). Read More

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http://dx.doi.org/10.2147/OTT.S195635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415729PMC
March 2019
1.342 Impact Factor

Evaluation of a new slim radial echoendoscope: A better option for an aging population.

Endosc Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Department of Medical and Surgical Sciences, GI Unit, Hospital of Imola, University of Bologna, Bologna, Italy.

Background And Objectives: The radial echoendoscope is still widely used for the investigation of abnormalities in the gastrointestinal wall and for stone detection in the extrahepatic biliary tree. Due to aging patient population, EUS is frequently performed in fragile and elderly individuals. We aimed to compare the maneuverability and image quality of a new thin radial echoendoscope to the current one. Read More

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http://dx.doi.org/10.4103/eus.eus_3_19DOI Listing
March 2019
1 Read

Reconstruction of intercalary bone defect after resection of malignant bone tumor.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019832970

1 Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Due to accurate preoperative imaging techniques, early diagnosis and effective chemotherapy, many tumors arising in the metaphyseo-diaphyseal regions of long bones can be segmentally resected with joint preservation. The intercalary resection of malignant bone tumor results in a bone defect which can represent a challenging reconstructive problem. The most commonly used surgical reconstructive options for these defects include biologic reconstructions such as allografts, vascularized fibular grafts, autogenous extracorporeally devitalized tumor bearing bone graft, combination of allografts or devitalized autografts with vascularized fibular grafts, segmental bone transport, or induced membrane technique. Read More

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http://dx.doi.org/10.1177/2309499019832970DOI Listing
March 2019
3 Reads

Decorin as a prognostic biomarker in patients with malignant peripheral nerve sheath tumors.

Oncol Lett 2019 Mar 23;17(3):3517-3522. Epub 2019 Jan 23.

Division of Rare Cancer Research, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue sarcomas. The prognosis of MPNSTs has been reported to differ among previous studies. However, there have been a number of reported prognostic biomarkers associated with MPNSTs. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.9959
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http://dx.doi.org/10.3892/ol.2019.9959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396138PMC
March 2019
7 Reads

Effect of Endocuff use on colonoscopy outcomes: A systematic review and meta-analysis.

World J Gastroenterol 2019 Mar;25(9):1158-1170

Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome 00153, Italy.

Background: Endocuff - a plastic device with flexible projections - mounted on the distal tip of the colonoscope, promises improved colonic mucosa inspection.

Aim: To elucidate the effect of Endocuff on adenoma detection rate (ADR), advanced ADR (AADR) and mean number of adenomas per colonoscopy (MAC).

Methods: Literature searches identified randomized-controlled trials evaluating Endocuff-assisted colonoscopy (EAC) conventional colonoscopy (CC) in terms of ADR, AADR and MAC. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i9/1158.htm
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http://dx.doi.org/10.3748/wjg.v25.i9.1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406188PMC
March 2019
4 Reads

Multiple schwannomas of the digital nerves and common palmar digital nerves: An unusual case report of multiple schwannomas in one hand.

Medicine (Baltimore) 2019 Mar;98(10):e14605

Department of Hand Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China.

Rationale: Benign schwannoma is the most common tumor of peripheral nerves while plexiform multiple schwannomas are rare conditions. This manuscript reported a case of multiple Schwannomas characterized by unusual location.

Patient Concerns: We report a 34-year-old workman presented with multiple nodules in his forefinger, middle finger and palm respectively for 5 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000014605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417492PMC
March 2019
1 Read

Phalangeal fracture leading to digital amputation, sustained during manipulation for Dupuytren's disease as part of clostridial collagenase treatment.

Ann R Coll Surg Engl 2019 Apr 11;101(4):e102-e104. Epub 2019 Mar 11.

Plastic and Reconstructive Surgery Department, Salisbury District Hospital, Salisbury , Salisbury , UK.

Collagenase injection was approved in Europe for use in the treatment of Dupuytren's disease in 2011. Reported adverse effects include skin tears, swelling, pain and complex regional pain syndrome. Here, we present a case of a rare complication of phalangeal fracture following treatment with collagenase clostridium and the resultant digital amputation. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432953PMC
April 2019
2 Reads

Hormone naïve metastatic prostate cancer: How to treat it?

Arch Esp Urol 2019 Mar;72(2):192-202

Department of Urology. Herlev and Gentofte Hospital. Herlev. Denmark.

Objectives: Recent landmark studies (GETUG-AFU 15, CHAARTED, STAMPEDE (docetaxel), LATITUDE and STAMPEDE (abiraterone)) have changed the treatment of hormone sensitive metastatic prostate cancer (mHSPC) from androgen deprivation therapy (ADT) only to combined therapy with either docetaxelor abiraterone acetate plus prednisone (AAP) together with ADT. In this Review we highlight current evidence and recommendations on how to treat men with newly diagnosed mHSPC beyond ADT. METHODS: Narrative overview of available evidence retrieved from pubmed searches, hand searches and authoritative texts. Read More

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March 2019
6 Reads

Relationship of common variants in Interleukin 33 gene with susceptibility and prognosis of osteosarcoma in Han Chinese population.

J Cancer 2019 29;10(5):1138-1144. Epub 2019 Jan 29.

Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.

Osteosarcoma (OS) is one of the most common malignant bone tumors. Many previous studies have indicated that OS is a complex disease and that its development may be affected by multiple genetic factors, which may contribute to its carcinogenesis. The aim of the present study was to evaluate the relationship of with susceptibility and prognosis of OS in Han Chinese individuals. Read More

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http://dx.doi.org/10.7150/jca.29086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400670PMC
January 2019
1 Read

Just a cutaneous (keratotic) horn?

BMJ 2019 Mar 7;364:l595. Epub 2019 Mar 7.

Silverdale Medical Practice, Salford, Manchester, UK.

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http://dx.doi.org/10.1136/bmj.l595DOI Listing

Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - a long-term observation.

Radiat Oncol 2019 Mar 7;14(1):39. Epub 2019 Mar 7.

Department of Radiation Oncology, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Background: Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL and its risk factors in the long-term using self-reported symptoms. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-019-1243-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407279PMC
March 2019
6 Reads

Nephrometry score correlated with tumor proliferative activity inT1 clear cell renal cell carcinoma.

Urol Oncol 2019 May 27;37(5):301.e19-301.e25. Epub 2019 Feb 27.

Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido.

Objective: To evaluate the association between the RENAL nephrometry score (RNS) and tumor proliferative activity assessed by immunohistochemistry in patients with localized renal cell carcinoma.

Methods: The current study included 145 pathological T1 (pT1) clear cell renal cell carcinomas (ccRCC). Tumor proliferative activity was assessed with the Ki67 index and microvessel density (MVD). Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.02.005DOI Listing
May 2019
1 Read

Primarily resectable pancreatic adenocarcinoma - to operate or to refer the patient to an oncologist?

Crit Rev Oncol Hematol 2019 Mar 25;135:95-102. Epub 2019 Jan 25.

Department of Radiotherapy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

The aim of this work is to investigate the optimal therapeutic sequence of resectable pancreatic cancer - primary surgery with adjuvant therapy or neoadjuvant followed by resection. Application of the neoadjuvant approach in routine treatment of pancreatic cancer is rapidly growing every year, despite the lack of final results from randomized trials. Recent advancements in the adjuvant therapy, due to the more effective chemotherapy regimens, favor the upfront surgery strategy. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.01.010DOI Listing

Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants.

Plast Reconstr Surg 2019 03;143(3S A Review of Breast Implant-Associated Anaplastic Large Cell Lymphoma):30S-40S

Sydney, New South Wales, Brisbane, Queensland, and Melbourne, Victoria, Australia; Almelo, The Netherlands; and Vancouver, British Columbia, Canada From the Department of Plastic, Reconstructive, and Maxillofacial Surgery, Macquarie University; Integrated Specialist Healthcare Education and Research Foundation; Department of Plastic, Reconstructive, and Hand Surgery, Medisch Spectrum Twente, Enschede and ZGT Almelo; Division of Plastic Surgery, University of British Columbia; Griffith University; and Monash University.

Background: With breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) now accepted as a unique (iatrogenic) subtype of ALCL directly associated with textured breast implants, we are now at a point where a sound epidemiologic profile and risk estimate are required. The aim of this article is to provide a comprehensive and up-to-date global review of the available epidemiologic data and literature relating to the incidence, risk, and prevalence of BIA-ALCL.

Methods: All current literature relating to the epidemiology of BIA-ALCL was reviewed. Read More

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http://Insights.ovid.com/crossref?an=00006534-201903001-0000
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http://dx.doi.org/10.1097/PRS.0000000000005567DOI Listing
March 2019
4 Reads

Subjective morbidity following radial free flap reconstruction in head and neck tumour patients.

J Laryngol Otol 2019 Mar 28;133(3):230-235. Epub 2019 Feb 28.

Department of Otolaryngology Head and Neck Surgery,University of Cincinnati Medical Center/College of Medicine,Ohio,USA.

Objective: Evaluation of post-operative donor site disability remains unaddressed in radial forearm free flap cases. This study aimed to assess donor site dysfunction following radial forearm free flap harvest using validated general, disease-specific and site-specific disability questionnaires.

Methods: In this retrospective case series of 24 patients at a tertiary academic medical centre, patients were assessed using the Short Form 36 Health Survey, Short Musculoskeletal Function Assessment questionnaire, and Disabilities of the Arm, Shoulder and Hand questionnaire. Read More

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http://dx.doi.org/10.1017/S0022215119000197DOI Listing

Budget impact analysis of cervical cancer screening in Portugal: comparison of cytology and primary HPV screening strategies.

BMC Public Health 2019 Feb 26;19(1):235. Epub 2019 Feb 26.

Roche Diagnostics, Almere, the Netherlands.

Background: Primary Human Papilloma Virus (HPV) testing is the currently recommended cervical cancer (CxCa) screening strategy by the Portuguese Society of Gynecology (SPG) clinical consensus. However, primary HPV testing has not yet been adopted by the Portuguese organized screening programs. This modelling study compares clinical benefits and costs of replacing the current practice, namely cytology with ASCUS HPV triage, with 2 comparative strategies: 1) HPV (pooled) test with cytology triage, or 2) HPV test with 16/18 genotyping and cytology triage, in organized CxCa screenings in Portugal. Read More

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http://dx.doi.org/10.1186/s12889-019-6536-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391842PMC
February 2019
1 Read

Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes.

Tumour Biol 2019 Jan;41(1):1010428318815413

3 Department of Oncology and Radiotherapy and Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a major regulator of the oxidative stress response and it is negatively regulated by Kelch-like ECH-associated protein 1 (Keap1). The Keap1-Nrf2 axis has a fundamental role in carcinogenesis. In previous studies, the widely used diabetes drug metformin has appeared to have a critical role in the regulation of Nrf2 function. Read More

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http://dx.doi.org/10.1177/1010428318815413DOI Listing
January 2019
2 Reads

DNA demethylation with 5-aza-2'-deoxycytidine induces the senescence-associated secretory phenotype in the immortal fish cell line, EPC.

Gene 2019 May 22;697:194-200. Epub 2019 Feb 22.

Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.

Fish cell lines are known to be immortal and do not show the signs of cellular senescence despite the absence of transformation. Furthermore, high telomerase activities responsible for maintenance of telomere length are detected in many organs in live fish, irrespective of fish age. On the other hand, although it is reported that cytosine methylation at CpG island shores decreases as zebrafish age, the relationship between DNA methylation and cellular senescence in fish has not been explored. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.048DOI Listing

The 10-Min Holistic Self-Care for Patients with Breast Cancer-Related Lymphedema: Pilot Randomized Controlled Study.

Tohoku J Exp Med 2019 02;247(2):139-147

Department of Surgical Oncology, Tohoku University Graduate School of Medicine.

About 20% of patients with breast cancer are likely to develop breast cancer-related lymphedema (BCRL) following an axillary clearance, and BCRL can be refractory or irreversible to treatment. The aim of this pilot randomized controlled study was to evaluate the effectiveness of a 10-min holistic self-care program for patients with BCRL in Japan. The intervention group (n = 22) practiced the BCRL self-care program including 1) modified Japanese Radio Taiso (Rajio Taiso, national calisthenics in Japan), 2) gentle arm exercises combined with deep breathing, 3) central lymphatic drainage, and 4) skin care using a traditional lymphatic drainage technique daily for 6 months, while the control group (n = 21) received usual care from their hospitals. Read More

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http://dx.doi.org/10.1620/tjem.247.139DOI Listing
February 2019
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Cause-specific mortality in osteoarthritis of peripheral joints.

Osteoarthritis Cartilage 2019 Feb 21. Epub 2019 Feb 21.

Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden. Electronic address:

Purpose: To estimate cause-specific mortality in osteoarthritis patients compared to the general population.

Methods: We identified all residents in southern Sweden aged 45-84 years in 2003. Through the Skåne Healthcare Register (SHR) we identified those diagnosed with osteoarthritis in peripheral joints between 1998 and 2003. Read More

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http://dx.doi.org/10.1016/j.joca.2019.02.793DOI Listing
February 2019
2 Reads

Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.

Anal Chim Acta 2019 May 8;1056:146-152. Epub 2019 Jan 8.

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Spain; CIBER de Bioingenierıía, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.

A simple and effective colorimetric method for the detection of normetanephrine (NMN), an O-methylated metabolite of norepinephrine, using functionalised gold nanoparticles is described. This metabolite is an important biomarker in the diagnosis of adrenal tumours such as pheocromocytoma or paraganglioma. The colorimetric probe consists of spherical gold nanoparticles (AuNPs) functionalised with two different ligands, which specifically recognize different functional groups in normetanephrine. Read More

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http://dx.doi.org/10.1016/j.aca.2019.01.003DOI Listing
May 2019
3 Reads

Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b.

Med Sci Monit 2019 Feb 22;25:1410-1422. Epub 2019 Feb 22.

Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a functional long non-coding RNA involved in many biologic processes. The study was aimed to explore the functional roles of MALAT1 in osteosarcoma progression. MATERIAL AND METHODS A total of 76 osteosarcoma tissues and paired adjacent non-tumor tissues were collected from surgical resection. Read More

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https://www.medscimonit.com/abstract/index/idArt/912703
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http://dx.doi.org/10.12659/MSM.912703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396440PMC
February 2019
9 Reads

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells.

Sci Rep 2019 Feb 20;9(1):2399. Epub 2019 Feb 20.

Institute of Biology, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Developing tumors interact with the surrounding microenvironment. Myeloid cells exert both anti- and pro-tumor functions and chemokines are known to drive immune cell migration towards cancer cells. It is documented that CXCR4 signaling supports tumor metastasis formation in tissues where CXCL12, its cognate ligand, is abundant. Read More

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http://dx.doi.org/10.1038/s41598-019-38643-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382824PMC
February 2019

High resolution MRI of nail tumors and tumor-like conditions.

Eur J Radiol 2019 Mar 6;112:93-105. Epub 2019 Jan 6.

Division of Radiology, Department of Imaging and Medical Informatics, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland. Electronic address:

Although the nail is a small anatomical structure, it can be affected by various tumors and tumor-like conditions. Because of the distinctive nail anatomy, the clinical presentation of tumors is modified, thus rendering the diagnosis challenging. As nail biopsy and surgery are painful procedures associated with an increased risk of permanent onychodystrophy, pre-operative diagnosis is desirable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193000
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http://dx.doi.org/10.1016/j.ejrad.2019.01.004DOI Listing
March 2019
12 Reads

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer-a retrospective observational study.

World J Surg Oncol 2019 Feb 15;17(1):33. Epub 2019 Feb 15.

Department of Surgery Fujita Health University, 1-98 Dengakugakubo Kutsukake-cho, Toyoake City, Aichi, 470-1192, Japan.

Background: Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery, and palliative care. On the other hand, development of chemotherapeutic agents is remarkable and improves long-term survival. Read More

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http://dx.doi.org/10.1186/s12957-019-1575-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377761PMC
February 2019
9 Reads

[Chapter 6. Legal issues and for the health system of the development of a new class of innovative therapy in oncoimmunology: the “Car-T CellS”].

J Int Bioethique Ethique Sci 2018 Jul;29(2):113-128

Car-T Cells are autologous or allogeneic lymphocytes cells, genetically engineered to express a transmembrane receptor called ?chimeric? because it consists of the assembly of different parts of molecules. These new techniques using biotechnologies (cellular engineering and genetic modifications) are developing in a complex legal context integrating the rules of the European Union (EU) and national rules, aiming to guarantee a high level of security for products and techniques but also for patients. This framework can be either considered as a guaranty for the use of new molecules in a highly secure environment or as an impediment, on the one hand regarding those who want to develop them because of a great complexity in identifying the adequate procedures and regarding the scientific prerequisites expected by the control agencies, and on the other hand by patients who have to wait many years for these innovations to be made available. Read More

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http://dx.doi.org/10.3917/jibes.292.0113DOI Listing

Proteomic characterization of early lung response to breast cancer metastasis in mice.

Exp Mol Pathol 2019 04 11;107:129-140. Epub 2019 Feb 11.

Jagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET), Bobrzynskiego 14, 30-348 Krakow, Poland; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Toxicology, Medyczna 9, 30-688 Krakow, Poland. Electronic address:

Introduction: The tumor-promoting rearrangement of the lungs facilitates the process of cancer cell survival in a foreign microenvironment and enables their protection against immune defense. The study aimed to define the fingerprint of the early rearrangement of the lungs via the proteomic profiling of the lung tissue in the experimental model of tumor metastasis in a murine 4T1 mammary adenocarcinoma.

Materials And Methods: The studies were performed on 7-8-week-old BALB/c female mice. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.02.001DOI Listing

Sleeve-Shaped Neurothekeoma of the Ulnar Nerve: A Unique Case of a Still Unclear Pathological Entity.

Hand (N Y) 2019 Feb 14:1558944719828008. Epub 2019 Feb 14.

1 Fondazione I.R.C.C.S Istituto Neurologico Carlo Besta, Milan, Italy.

Background: Neurothekeomas are slow-growing, well-circumscribed benign neoplasms. They usually involve cutaneous or subcutaneous tissues. Although originally described as myxomas deriving from nerve sheath cells, their exact histological classification is still uncertain. Read More

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http://dx.doi.org/10.1177/1558944719828008DOI Listing
February 2019
2 Reads

Risk of lymph node metastasis in undifferentiated-type mucosal gastric carcinoma.

World J Surg Oncol 2019 Feb 13;17(1):32. Epub 2019 Feb 13.

Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Endoscopic resection (ER) has come to be recognized as a standard treatment for early gastric cancer (EGC). While its adoption is expanding, ER remains restricted to cases of EGC without lymph node metastasis for the treatment of local resection. On the other hand, histopathological analyses of surgically resected specimens of EGC have revealed the presence of lymph node (LN) metastasis in some cases of mucosal gastric cancer (MGC) and undifferentiated MGC (UD-MGC) is considered to have higher risk of nodal metastases than differentiated MGC (D-MGC). Read More

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http://dx.doi.org/10.1186/s12957-019-1571-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375195PMC
February 2019
1 Read

Hand Ischemia due to Steal Syndrome Associated with Multiple Arteriovenous Malformations in a Patient with Parkes-Weber Syndrome.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):89-92

† Section of Vascular Surgery and Endovascular Therapy, Mexico City, Mexico.

Parkes Weber Syndrome (PWS) is a congenital disorder characterized by the presence of arteriovenous malformations (AVMs) in upper or lower extremities. We herein present a 35 year-old male with PWS with complex AVMs in the right upper extremity; he had been previously treated with multiple sessions of vessel embolization, sclerotherapy and AVM resections. The patient presented to our clinic with two month history of progressive hand ischemia, digit necrosis and infection. Read More

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http://dx.doi.org/10.1142/S2424835519720019DOI Listing
March 2019
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Current Smoking Is Associated with Delayed Wound Healing But Not with Improvement of Contracture after the Open Palm Technique for Dupuytren's Disease.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):65-71

† Department of Orthopaedic Surgery, Wakamatsu Hospital, University of Occupational and Environmental Health, Kitakyushu, Japan.

Background: Some cases treated with open palm technique need relatively long wound healing time. This study aims to clarify whether the preoperative lifestyle-related diseases or factors are associated with surgical results after the open palm technique for Dupuytren's contracture.

Methods: The study included 122 fingers of 84 hands of 84 consecutive male patients with Dupuytren's contracture who were treated with McCash's open palm technique at our hospital from 1980 to 2016. Read More

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http://dx.doi.org/10.1142/S2424835519500127DOI Listing
March 2019
1 Read