448,140 results match your criteria Hand Malignant Tumors


A population-based cohort study to evaluate the effectiveness of lung cancer screening using low-dose CT in Hitachi city, Japan.

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.

Objectives: To evaluate the effectiveness of lung cancer screening using low-dose computed tomography for the general population, we conducted a retrospective cohort study of screening for participants among Hitachi residents.

Materials And Methods: Citizens aged 50-74 who underwent low-dose computed tomography screening at least once during 1998-2006 were defined as the computed tomography group, and those who underwent X-ray screening at least once during the same period, but did not receive low-dose computed tomography screening throughout the follow-up period, were defined as the XP group. We investigated the lung cancer incidence rate, mortality rate and all-cause mortality rate for both groups from the first lung cancer screening to the end of 2012. Read More

View Article
December 2018

Inhibition of Manual Movements at Speech Arrest Sites in the Posterior Inferior Frontal Lobe.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, University of California San Francisco, San Francisco, California.

Background: Intraoperative stimulation of the posterior inferior frontal lobe (IFL) induces speech arrest, which is often interpreted as demonstration of essential language function. However, prior reports have described "negative motor areas" in the IFL, sites where stimulation halts ongoing limb motor activity.

Objective: To investigate the spatial and functional relationship between IFL speech arrest areas and negative motor areas (NMAs). Read More

View Article
December 2018

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Am J Clin Nutr 2018 Dec;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Read More

View Article
December 2018

Structural insights into nucleotide and protein sequence of Ageritin: a novel prototype of fungal ribotoxin.

J Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DISTABIF), University of Campania 'Luigi Vanvitelli', Via Vivaldi 43, Caserta, Italy.

Here, we report the amino acid sequence of Ageritin, the first ribotoxin-like protein from basidiomycetes (Agrocybe aegerita). This protein consists of 135 amino acid residues with a theoretical molecular mass of 14801.80 Da (experimental mass 14802. Read More

View Article
December 2018
1 Read

Galapagos Islands Endemic Vertebrates: A Population Genetics Perspective.

Authors:
Philip W Hedrick

J Hered 2018 Dec 12. Epub 2018 Dec 12.

School of Life Sciences, Arizona State University, Tempe, AZ.

The organisms of the Galapagos Islands played a central role in the development of the theory of evolution by Charles Darwin. Examination of the population genetics factors of many of these organisms with modern molecular methods have expanded our understanding of their evolution. Here I provide a perspective on how selection, gene flow, genetic drift, mutation, and inbreeding have contributed to the evolution of six of the iconic Galapagos species; flightless cormorant, pink iguana, marine iguana, Galapagos hawk, giant tortoises, and Darwin's finches. Read More

View Article
December 2018

Sequential transmission electron microscopy observation of the shape change of gold nanorods under pulsed laser light irradiation.

Microscopy (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Department of Applied Quantum Physics and Nuclear Engineering, Kyushu University, Motooka, Nishi-ku, Fukuoka, Japan.

In situ sequential high-resolution observations were performed on gold nanorods under near-infra-red pulsed laser irradiation using a high-voltage electron microscope attached to a pulsed laser illumination system. The original nanorods were single crystals; the longer axes were oriented along [001]. Under laser light irradiation with λ = 1064 nm with an average intensity per pulse of 980 or 490 J/m2, the shape of the nanorods changed from rod to barrel surrounded by the {111} and {001} facets, while the original single-crystalline structure was maintained. Read More

View Article
December 2018

The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.

Fish Shellfish Immunol 2018 Dec 9. Epub 2018 Dec 9.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China; Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan, 430070, China; Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, 430070, China. Electronic address:

Viperin is known to play an important role in innate immune and its antiviral mechanisms are well demonstrated in mammals. Fish Viperin mediates antiviral activity against several viruses. However, little has been done to the underlying mechanism. Read More

View Article
December 2018
1 Read

3D Quantification of the Facet Evolution of Pt Nanoparticles in a Variable Gaseous Environment.

Nano Lett 2018 Dec 12. Epub 2018 Dec 12.

Pt nanoparticles play an essential role in a wide variety of catalytic reactions. The activity of the particles strongly depends on their three-dimensional (3D) structure and exposed facets, as well as on the reactive environment. High resolution electron microscopy has often been used to characterize nanoparticle catalysts, but unfortunately, most observations so far have been either performed in vacuum and/or using conventional (2D) in situ microscopy. Read More

View Article
December 2018
1 Read

Comparison of Wide-Awake Local Anesthesia No Tourniquet With General Anesthesia With Tourniquet for Volar Plating of Distal Radius Fracture.

Orthopedics 2018 Dec 11:1-6. Epub 2018 Dec 11.

Wide-awake local anesthesia no tourniquet (WALANT) is used for various hand surgeries, but there are no reports of its use for distal radius fractures. The authors compared perioperative variables and clinical outcomes for volar plating for distal radius fractures with WALANT vs general anesthesia with tourniquet. This retrospective study included 47 patients who presented with distal radius fractures between January 2015 and February 2017. Read More

View Article
December 2018

Occlusion Outside the Norm: A Unique Case of the Pulseless, Well-Perfused Hand Following Closed Humeral Shaft Fracture.

Orthopedics 2018 Dec 11:1-3. Epub 2018 Dec 11.

Transient arterial injury is a common complication encountered in the management of pediatric supracondylar humerus fractures, often presenting as a pulseless hand that appears well perfused, also known as the "pink, pulseless hand." Arterial injuries in pediatric humeral shaft fractures, on the other hand, are exceedingly rare, especially in closed fractures. The authors report a rare case of a humeral shaft fracture presenting as a pink, pulseless hand. Read More

View Article
December 2018

Different clinical features according to the anastomotic leakage subtypes after rectal cancer surgeries: contained vs. free leakages.

PLoS One 2018 12;13(12):e0208572. Epub 2018 Dec 12.

Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Background: Anastomotic leakage can be classified by free and contained leakage according to clinical manifestations. The risk factors and their comparison between these leakage subtypes are uncertain. This study aims to evaluate anastomotic leakage patterns and to compare clinical features between free and contained leakages after low anterior resection for rectal cancer. Read More

View Article
December 2018
1 Read

Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function.

PLoS One 2018 12;13(12):e0208231. Epub 2018 Dec 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.

The metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease associated with reduced physical fitness, higher disease burden, and impaired cognitive functions. Little is known about the operation of these risk factors in older adults when considered comprehensively without relying on the cut-off values of the single MetS components. The three main aims of the current study were to: (i) establish a latent metabolic load factor (MetL), using confirmatory factor analysis (CFA), and representing a continuous measure of MetL, defined by indicators that are commonly used to separate MetS groups from healthy individuals; (ii) examine the associations of this MetL factor with objective health, and cognitive function in men and women; (iii) compare the magnitude of these associations to those observed for the individual indicators used to define the MetL factor as well to the classical categorized MetS vs. Read More

View Article
December 2018

Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

View Article
January 2019

The effect of task-oriented electromyography-triggered electrical stimulation of the paretic wrist extensors on upper limb motor function early after stroke: a pilot randomized controlled trial.

Int J Rehabil Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey.

The combined effect of task-oriented motor training and electromyography (EMG)-triggered electrical stimulation (ES) has been examined in chronic stroke, but there are no published reports in patients with early stroke. Therefore, the purpose of this study was to determine the short-term and long-term effects of task-oriented EMG-triggered ES on upper limb motor function in acute/subacute stroke. Twenty-seven patients with stroke within the first 3 months after stroke onset were randomly allocated to an experimental group and a control group. Read More

View Article
December 2018
1 Read

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

View Article
December 2018

Chemical activation of the ethylene signalling pathway promotes Fusarium graminearum resistance in detached wheat heads.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

University of Lethbridge, Department of Biological Sciences, Lethbridge, Alberta, Canada ;

Plant signalling hormones, such as ethylene, have been shown to affect the host response to various pathogens. Often the resistance responses to necrotrophic fungi are mediated through synergistic interactions of ethylene (ET) with the jasmonate signalling pathway. On the other hand, ethylene is also an inducer of senescence and cell death, which could be beneficial for some invading necrotrophic pathogens. Read More

View Article
December 2018

Gas Reforming and Tar Decomposition Performance of NiO/SBA-15 Catalyst in Gasification of Woody Biomass.

J Air Waste Manag Assoc 2018 Dec 12. Epub 2018 Dec 12.

b Okayama University , Okayama , Japan.

In the gasification of biomass, it is necessary to limit the amount of by-product tar and increase the yields of hydrogen and carbon monoxide (syngas). Therefore, we conducted gasification and reforming experiments on woody biomass using an electric tubular furnace, to evaluate the gas reforming and tar decomposition performance of a NiO/SBA-15 catalyst. As a result, we found that this catalyst is effective for H production. Read More

View Article
December 2018

Effects of Mirror-Box Therapy on Modulation of Sensorimotor EEG Oscillatory Rhythms: A Single-Case Longitudinal Study.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

3Pacific Development and Technology, LLC.

We provide direct electrophysiological evidence that Mirror Therapy (MT) can change brain activity and aid in recovery of motor function after stroke. In this longitudinal single-case study, the subject was a 58-year-old man with right-hand hemiplegia due to ischemic stroke. Over a nine-month period we treated him with MT twice a week and measured electroencephalograms (EEG) before, during, and after each therapy session. Read More

View Article
December 2018

[Dark personality traits at work].

Psychiatr Hung 2018 ;33(4):359-373

Pecsi Tudomanyegyetem, Pszichologia Intezet, Pecs, Hungary, E-mail:

Nowadays there has been an increase of scientific interest related to the dark triad of personality: Machiavellianism, subclinical narcissism and subclinical psychopathy. In the last two decades several studies were published about the work related correlates of the dark personality traits. The aim of the current paper is to summarize and review these international and Hungarian research findings. Read More

View Article
January 2018

[The role of perfectionism, social phobia, self-efficacy and life satisfaction in the background of trait anxiety].

Psychiatr Hung 2018 ;33(4):347-358

Szegedi Tudomanyegyetem Bolcseszettudomanyi Kar, Nevelestudomanyi Doktori Iskola, Szeged, Hungary, E-mail:

Background And Aims Of The Study: Anxiety related studies often investigate the personality factors and possible comorbid anxiety disorders that may underly trait anxiety. Women have higher prevalence rates across anxiety disorders, so we chose to examine the trait anxiety, perfectionism, self-efficacy and life satisfaction in a group of female participants.

Method: An online, self-reported questionnaire was used as an online method of data collection. Read More

View Article
January 2018

[Close-to-win evaluations are affected by the outcome and delay between stopping the wheels in slot machines].

Psychiatr Hung 2018 ;33(4):340-346

Debreceni Egyetem, Pszichologiai Intezet, Szemelyiseg- es Klinikai Pszichologia Tanszek, Debrecen, Hungary, E-mail:

Introduction: Distinct structural characteristics of gambling may affect the development of gambling addiction differently. The current study is dealing with the frequency of near-miss outcomes which works like secondary reinforcement and thus may contribute to gambling addiction. Authors of this paper argue that different near miss configurations should specifically alter the experiences of the player and this phenomenon can be proved experimentally Methods: Participants played with a computer-simulated slot machine. Read More

View Article
January 2018

Value-based medicine in oncology: the importance of perspective in the emerging value frameworks.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e470s. Epub 2018 Dec 10.

Centro de Investigacao Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Recently, professional and healthcare-related entities have launched frameworks designed to assess the value of cancer innovations in multistakeholder decision processes. Among the most visible entities that propose and implement value frameworks in oncology are the European Society of Medical Oncology (ESMO), the American Society of Clinical Oncology (ASCO), the Memorial Sloan Kettering Cancer Center (MSKCC) and the National Comprehensive Cancer Network (NCCN). However, these value frameworks have been criticized for conceptual inconsistencies, inability to include a greater variety of value criteria, and inadequate explanation of the uncertainty approach used in the modeling process. Read More

View Article
December 2018

Clinicopathological Features of Nondiabetic Renal Diseases from Different Age Groups: An Observational Cross-sectional Study.

Chin Med J (Engl) 2018 Dec;131(24):2953-2959

Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.

Background: Diabetes mellitus (DM) has become the leading cause of chronic kidney disease (CKD). Nondiabetic renal diseases (NDRDs) have different clinicopathological features and prognosis from those of diabetic nephropathy. Our study sought to analyze the clinical and pathological features of NDRDs, in different age groups through a cross-sectional study. Read More

View Article
December 2018

Identification of significant ego networks and pathways in rheumatoid arthritis.

J Cancer Res Ther 2018 Dec;14(Supplement):S1024-S1028

Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, 830001, Xinjiang, China.

Objective: The objective of this paper is to identify ego networks and pathways in rheumatoid arthritis (RA) based on EgoNet algorithm and pathway enrichment analysis.

Materials And Methods: The ego networks were identified based on the EgoNet algorithm which was comprised four steps: inputting gene expression data and protein-protein interaction data, identifying ego genes based on topological features of genes in background network, collecting ego networks by conducting snowball sampling for each ego gene, and estimating statistical significance of ego networks utilizing permutation test. To further explore the gene compositions of significant ego networks, pathway enrichment analysis was performed for each of them to investigate ego pathways in the progression of RA. Read More

View Article
December 2018

Surgical treatment for severe cubital tunnel syndrome with absent sensory nerve conduction.

Neural Regen Res 2019 Mar;14(3):519-524

Department of Hand Surgery, Huashan Hospital, Fudan University; Key Laboratory of Hand Reconstruction, Ministry of Health; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.

For severe cubital tunnel syndrome, patients with absent sensory nerve action potential tend to have more severe nerve damage than those without. Thus, it is speculated that such patients generally have a poor prognosis. How absent sensory nerve action potential affects surgical outcomes remains uncertain owing to a scarcity of reports and conflicting results. Read More

View Article

The tolerant immune system: Biological significance and clinical implications of T cell tolerance.

Endocr Metab Immune Disord Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari, Bari. Italy.

Background: T cell tolerance both at thymic and peripheral levels is a mechanism of protection finalized to eradicate autoreactive T cell clones and/or to maintain immune homeostasis, especially, postnatally. Central tolerance occurs in the thymic medulla via a mechanism of negative selection which leads to the eradication of autoreactive T cell clones. Mechanisms of action: Such a tolerogenic event relies on Fas-mediated apoptosis of autoreactive T cell clones operated by thymic dendritic cells (DCs), on the one hand. Read More

View Article
December 2018
1 Read

A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Service de rééducation et réadaptation de l'appareil locomoteur et des pathologies du rachis, Laboratoire de Pharmacologie, Toxicologie et Signalisation Cellulaire, Univ. Paris Descartes, PRES Sorbonne Paris Cité, Hôpital Cochin, Assistance Publique -Hôpitaux de Paris, INSERM UMR-S 1124, UFR Biomédicale des Saints Pères, Paris, France.

Background And Aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.

Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. Read More

View Article
December 2018

Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: a pilot randomized controlled trial.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Viale Piazza D'Armi, 1, 28100, Novara, Italy.

Background: Physical exercise and nutrition seem to have a key role in the management of hip fracture patients.

Aim: To evaluate the impact of a 2-month rehabilitative protocol combined with dietetic counseling, with or without essential amino acid supplementation, on functioning in hip fracture patients.

Methods: In this pilot randomized controlled study, we recruited patients aged more than 65 years, at 3 months after hip fracture. Read More

View Article
December 2018

The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Master of Science Program, Veiga de Almeida University, Rua Ibituruna 108, casa 3, sala 201, Tijuca, Rio de Janeiro, 20271-020, Brazil.

The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Read More

View Article
December 2018

Correction to: Finger Length Ratios of Identical Twins with Discordant Sexual Orientations.

Arch Sex Behav 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, University of Essex, Colchester, C04 3SQ, UK.

Readers should note that the confidence intervals for the effect of sexual orientation on 2D:4D in the left hand of female twins are incorrectly reported in Table 1 of this article. In particular, the upper limit of the confidence intervals is missing a minus sign. Read More

View Article
December 2018

Technical variations and feasibility of transanal ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified across continents.

Tech Coloproctol 2018 Dec 11. Epub 2018 Dec 11.

Cedars Sinai Medical Center, 8737 Beverly Blvd. Suite 101, Los Angeles, CA, 90048, USA.

Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers performing taIPAA across two continents.

Methods: Prospective IPAA registries from three institutions in the US and Europe were queried for patients undergoing taIPAA. Read More

View Article
December 2018

[Diagnostics and treatment of acute scaphoid fractures].

Unfallchirurg 2018 Dec 11. Epub 2018 Dec 11.

Abteilung für Plastische, Hand- und Rekonstruktive Chirurgie, BG Unfallklinik Frankfurt, Friedberger Landstr. 430, 60389, Frankfurt am Main, Deutschland.

Background: Fractures of the scaphoid bone are common but can easily be overlooked in standard X‑rays. Inadequate diagnostics and therefore inappropriate treatment of scaphoid fractures often leads to problems in healing with formation of non-union and painful osteoarthritis of the wrist.

Objective: This review summarizes the current practical recommendations in the diagnostics and treatment of acute scaphoid fractures. Read More

View Article
December 2018

A new classification for proximal femur bone defects in conservative hip arthroplasty revisions.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Orthopaedic and Traumatologic Department, Santo Spirito General Hospital, Rome, Italy.

Introduction: In the last three decades, total hip replacement in young patient became a habitual procedure. Principles of bone preservation are pushing many surgeons to implant conservative femoral components in patient younger than 65 years. Despite an overall good survivorship and clinical outcomes of conservative implants, failed cases are reported and the need to revise a conservative femoral component became an occasional procedure (with high prevalence of failed resurfacing implants). Read More

View Article
December 2018
1 Read

Judging risk magnitude: walking to the left and base jumping to the right.

Exp Brain Res 2018 Dec 11. Epub 2018 Dec 11.

School of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, Australia.

When thinking about quantifiable domains such as numbers, pitch, and size, they are implicitly mapped on to representational space with small/low/less and large/high/more of the respective domain represented on the left and right sides of representational space, respectively. Recent research has also demonstrated that more abstract domains (colours, language, political party names) are also mapped in the same way. This study investigated a new abstract domain, risk, to examine if this same pattern of effects is apparent (left = low risk/right = high risk) to get a better understanding of how risk magnitudes are processed. Read More

View Article
December 2018

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics.

Cell Mol Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Life Science, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India.

The efficacy of chemotherapy is mostly restricted by the drug resistance developed during the course of cancer treatment. Mitophagy, as a pro-survival mechanism, crucially maintains mitochondrial homeostasis and it is one of the mechanisms that cancer cells adopt for their progression. On the other hand, mitochondrial apoptosis, a precisely regulated form of cell death, acts as a tumor-suppressive mechanism by targeting cancer cells. Read More

View Article
December 2018
5.808 Impact Factor

A stability-reversibility map unifies elasticity, plasticity, yielding, and jamming in hard sphere glasses.

Sci Adv 2018 Dec 7;4(12):eaat6387. Epub 2018 Dec 7.

Cybermedia Center, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Amorphous solids, such as glasses, have complex responses to deformations, with substantial consequences in material design and applications. In this respect, two intertwined aspects are important: stability and reversibility. It is crucial to understand, on the one hand, how a glass may become unstable due to increased plasticity under shear deformations, and, on the other hand, to what extent the response is reversible, meaning how much a system is able to recover the original configuration once the perturbation is released. Read More

View Article
December 2018

Aqueous Decoction: A New Water-Soluble Polysaccharide and Antioxidant-Rich Extract.

Biomed Res Int 2018 12;2018:2691513. Epub 2018 Nov 12.

University of Carthage, Institut National des Sciences Appliquées et de Technologie (INSAT), 1080 Tunis, Tunisia_LETMI - INSAT, Tunisia.

Background: The decoction of yields an antioxidant-rich extract and a water-soluble polysaccharide. This study aims (1) to investigate the effect of process parameters (extraction time and temperature) on the antioxidant activity of the decoction and the extraction yield of CPGP by response methodology and (2) to study the chemical properties of the optimized decoction and rheological properties of the corresponding extracted polysaccharide.

Results: The antioxidant-rich decoction contained about 19. Read More

View Article
November 2018
1 Read

Presence of cadmium residues in muscle, liver and kidney of and histological evidence.

Ital J Food Saf 2018 Sep 7;7(3):7684. Epub 2018 Nov 7.

Department of Veterinary Medicine, University of Bari "Aldo Moro".

Cadmium (Cd) concentrations were evaluated in the samples of kidney, liver and muscle of sixty-six buffaloes regularly slaughtered. Forty were raised in Campania, in the territory between the province of Naples and Caserta and twenty-six were bred in Apulia, in the province of Bari. Two aliquots were prepared for the renal and hepatic samples: one intended for the chemical analysis and the other one intended for histological investigations. Read More

View Article
September 2018

Unusual Etiology of Acute Wrist Pain: Acute Calcific Tendonitis of the Flexor Carpi Ulnaris Mimicking an Infection.

Authors:
Man R Shim

Case Rep Orthop 2018 14;2018:2520548. Epub 2018 Nov 14.

Department of Medicine, Rheumatology Division, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Acute calcific tendonitis is a common cause of musculoskeletal pain. However, it seldom affects the hand and wrist. For that reason, it is frequently mistaken for more common etiologies. Read More

View Article
November 2018

The Effect of Periarticular Injection of Methylprednisolone Acetate in Patients with Primary Osteoarthritis of the Proximal Interphalangeal Joints: A Case Controlled Study.

Pain Res Treat 2018 14;2018:7561209. Epub 2018 Nov 14.

Department of Orthopedics, Carmel Medical Center, Haifa, Israel.

Backgrounds: Primary osteoarthritis of the proximal interphalangeal joints (PIPJ) is a common entity. It could be associated with local pain that has no effective treatment. Local subcutaneous periarticular injection of methylprednisolone acetate (MPA) was evaluated in a prospective case-control study. Read More

View Article
November 2018

Wireless Patrol Sign-In System with Mental Fatigue Detection.

J Healthc Eng 2018 12;2018:6419064. Epub 2018 Nov 12.

Department of Computer Science and Information Engineering, Chaoyang University of Technology, 168, Jifeng E. Rd., Wufeng District, Taichung 41349, Taiwan.

Current sign-in methods of patrolling security guards mainly comprise signature, image identification, and fingerprint identification; notably, none of these methods indicate the physical and mental conditions of such guards. In particular, when patrolling security guards perform their duties consecutively for a long period of time, adequate attention should be directed toward their levels of mental fatigue. When a handwriting sign-in system is adopted, security guards may not record their sign-in time accurately, or they may fake signatures during long shifts. Read More

View Article
November 2018

Time Course of Upper Limb Function in Children with Unilateral Cerebral Palsy: A Five-Year Follow-Up Study.

Neural Plast 2018 14;2018:2831342. Epub 2018 Nov 14.

KU Leuven, University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.

Knowledge on long-term evolution of upper limb function in children with unilateral cerebral palsy (CP) is scarce. The objective was to report the five-year evolution in upper limb function and identify factors influencing time trends. Eighty-one children (mean age 9 y and 11 mo, SD 3 y and 3 mo) were assessed at baseline with follow-up after 6 months, 1, and 5 years. Read More

View Article
November 2018

Multiple color patches and parasites in : differential relationships by sex and infection.

Curr Zool 2018 Dec 22;64(6):703-711. Epub 2018 Jan 22.

Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, 1156 High St, Santa Cruz, CA, USA.

Parasites generally have a negative influence on the color expression of their hosts. Sexual selection theory predicts resistant high-quality individuals should show intense coloration, whereas susceptible low-quality individuals would show poor coloration. However, intensely colored males of different species of Old and New World lizards were more often infected by hemoparasites. Read More

View Article
December 2018

Geography and Environment Shape Landscape Genetics of Mediterranean Alpine Species Poiret. (Caryophyllaceae).

Front Plant Sci 2018 27;9:1698. Epub 2018 Nov 27.

Área de Biodiversidad y Conservación, Escuela Superior de Ciencias Experimentales y Tecnología (ESCET), Universidad Rey Juan Carlos, Madrid, Spain.

The study of the drivers that shape spatial genetic structure across heterogeneous landscapes is one of the main approaches used to understand population dynamics and responses in changing environments. While the Isolation-by-Distance model (IBD) assumes that genetic differentiation increases among populations with geographical distance, the Isolation-by-Resistance model (IBR) also considers geographical barriers and other landscape features that impede gene flow. On the other hand, the Isolation-by-Environment model (IBE) explains genetic differentiation through environmental differences between populations. Read More

View Article
November 2018

Hand Grip Strength as a Clinical Biomarker for ME/CFS and Disease Severity.

Front Neurol 2018 27;9:992. Epub 2018 Nov 27.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, International Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine, London, United Kingdom.

The diagnosis of myalgic encephalomyelitis (ME/CFS) in research and clinical practice has largely relied on clinical history, which can be subjective in nature. Clinical signs are often subtle, overlap with other conditions, and are not formally included as part of diagnostic workup. The characterization of clinical signs and biomarkers is needed for better diagnosis and classification of patients and to monitor treatment response. Read More

View Article
November 2018

High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database.

Cancer Manag Res 2018 20;10:6003-6014. Epub 2018 Nov 20.

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, People's Republic of China,

Purpose: Liver cancer is a high mortality disease with no curable treatments. Posttranscriptional modifications play essential roles in the occurrence and the progression of liver cancer. EIF2B5 is a subunit of EIF2B that regulates the initiation and the rate of translation and participates in several diseases including tumors. Read More

View Article
November 2018

A novel de novo mutation in a patient with Holt-Oram syndrome.

Appl Clin Genet 2018 23;11:157-162. Epub 2018 Nov 23.

Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Valle del Cauca, Colombia,

Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterized by congenital cardiac defects and congenital deformities of the upper limbs. Herein, we report the case of a 2-year-old patient presenting with clinical diagnostic criteria of HOS with interatrial and interventricular communication associated with hip dysplasia and upper limb reduction composed of radial ray anomaly. A novel de novo, potentially pathogenic variant in the gene at NM_181486. Read More

View Article
November 2018

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

Blood Adv 2018 Dec;2(23):3553-3565

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD.

GATA2 deficiency is an inherited or sporadic genetic disorder characterized by distinct cellular deficiency, bone marrow failure, various infections, lymphedema, pulmonary alveolar proteinosis, and predisposition to myeloid malignancies resulting from heterozygous loss-of-function mutations in the gene. How heterozygous mutations affect human hematopoietic development or cause characteristic cellular deficiency and eventual hypoplastic myelodysplastic syndrome or leukemia is not fully understood. We used induced pluripotent stem cells (iPSCs) to study hematopoietic development in the setting of GATA2 deficiency. Read More

View Article
December 2018

Developmental considerations in survival models as applied to substance use research.

Addict Behav 2018 Nov 20. Epub 2018 Nov 20.

Brown University, United States.

Survival analysis is a class of models that are ideal for evaluating questions of timing of events, which makes them well-suited for modeling the development of a process such as initiation of substance use, development of addiction, or post-treatment recovery. The focus of this review paper is to demonstrate how survival models operate in a broader developmental framework and to offer guidance on selecting the appropriate model on the basis of the research question at hand. We provide a basic overview of survival models and then identify several key issues, explain how they pertain to research in the addiction field, and describe studies that utilize survival models to address questions about timing. Read More

View Article
November 2018

Repeated Aluminum Sulfate Recovery from Waterworks Sludge: A Case Study in El-Sheikh Zaid WTP.

Water Environ Res 2018 Dec;90(12):2030-2035

Although surface water treatment presents a good solution for pollutants in rivers and freshwater lakes, the purification process itself presents a great threat to the aquatic environment through aluminum waste disposal. Recent studies have introduced coagulants recovery from treatment sludge as a green solution for waste handling and cost reduction. This article aims to evaluate repeated aluminum coagulants recovery from sludge using sulfuric acid. Read More

View Article
December 2018