35,084 results match your criteria Hand Infections


"Clean care for all - it's in your hands": the May 5, 2019 World Health Organization SAVE LIVES: Clean Your Hands campaign.

J Infect 2019 May;78(5):409-421

Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.04.008DOI Listing

Comparative metabolomics of temperature sensitive resistance to wheat streak mosaic virus (WSMV) in resistant and susceptible wheat cultivars.

J Plant Physiol 2019 Apr 12;237:30-42. Epub 2019 Apr 12.

Group of Genetics, Breeding and Biochemistry of Brassicas. Misión Biológica de Galicia (MBG-CSIC), Apartado 28, 36080 Pontevedra, Spain.

In order to evaluate wheat resistance to wheat streak mosaic virus (WSMV) at low temperature and resistance breakdown at high temperature, metabolic profile of WSMV-resistant (R) and susceptible (S) wheat cultivars were analyzed. Metabolites were detected by UPLC-QTOF/MS in leaves of R and S plants challenged with WSMV at 20 °C and 32 °C, 24, 48 and 72 h post inoculation (hpi). WSMV and mock inoculated plants were used for discriminating the most significant metabolites and metabolic pathways affected at those temperatures. Read More

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http://dx.doi.org/10.1016/j.jplph.2019.03.011DOI Listing

Long-Term Outcomes of Atasoy Flap in Children With Distal Finger Trauma.

J Hand Surg Am 2019 Apr 17. Epub 2019 Apr 17.

Department of Paediatric Orthopaedic Surgery, Amiens University Hospital and Jules Verne University of Picardy, Amiens, France. Electronic address:

Purpose: Distal finger trauma is one of the most frequent emergencies in children and has the potential for functional and cosmetic damage to the hand. The Atasoy flap (AF) is a vascularized, subcutaneous pedicle V-Y advancement flap used to cover a loss of distal finger substance. Our hypothesis was that the AF is a safe, reliable flap that results in few complications and gives satisfactory functional and cosmetic results in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03635023183072
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http://dx.doi.org/10.1016/j.jhsa.2019.02.018DOI Listing
April 2019
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Pitfalls and Unexpected Benefits of an Electronic Hand Hygiene Monitoring System.

Am J Infect Control 2019 Apr 17. Epub 2019 Apr 17.

Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA. Electronic address:

Background: No single strategy is more effective than proper hand hygiene (HH) in reducing the spread of nosocomial infections. Unfortunately, health care worker compliance with HH is imperfect. We sought to improve HH compliance using an electronic hand hygiene monitoring system (EHHMS) in 2 units to collect unbiased data and provide feedback. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.011DOI Listing

Impact of water quality, sanitation, handwashing, and nutritional interventions on enteric infections in rural Zimbabwe: the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, VA, USA.

Background: We assessed the impact of water, sanitation, and hygiene (WASH) and infant and young child feeding (IYCF) interventions on enteric infections in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe.

Methods: We tested stool samples collected at 1, 3, 6, and 12 months of age and during diarrhea using quantitative molecular diagnostics for 29 pathogens. We estimated the effects of the WASH, IYCF, and combined WASH+IYCF on individual enteropathogen prevalence and quantity, total numbers of pathogens detected, and incidence of pathogen-attributable diarrhea. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz179DOI Listing
April 2019
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Collagen nerve conduits and processed nerve allografts for the reconstruction of digital nerve gaps: a single institution case series and review of the literature.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, Division of Hand and Microvascular Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, USA. Electronic address:

Objective: A single institution case series and review of the literature on the outcomes of digital nerve gap reconstruction with the NeuraGen type 1 collagen nerve conduit (Integra Life Sciences, Plainsboro NJ) and the Avance Nerve Graft (Axogen, Inc, Alachua, FL).

Methods: 37 patients were included with a minimal follow-up of 12 months. Primary outcome was postoperative sensory recovery measured by static two-point discrimination (S2PD) test or the Semmes-Weinstein monofilament test (SWM). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.087DOI Listing

Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus (S.aureus) is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193037
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http://dx.doi.org/10.1016/j.micpath.2019.04.026DOI Listing
April 2019
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Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Medical prescribing and antibiotic resistance: A game-theoretic analysis of a potentially catastrophic social dilemma.

PLoS One 2019 19;14(4):e0215480. Epub 2019 Apr 19.

Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

The availability of antibiotics presents medical practitioners with a prescribing dilemma. On the one hand, antibiotics provide a safe and effective treatment option for patients with bacterial infections, but at a population level, over-prescription reduces their effectiveness by facilitating the evolution of bacteria that are resistant to antibiotic medication. A game-theoretic investigation, including analysis of equilibrium strategies, evolutionarily stability, and replicator dynamics, reveals that rational doctors, motivated to attain the best outcomes for their own patients, will prescribe antibiotics irrespective of the level of antibiotic resistance in the population and the behavior of other doctors, although they would achieve better long-term outcomes if their prescribing were more restrained. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215480PLOS

Soft tissue free flap for reconstruction of upper extremities: A meta-analysis on outcome and safety.

Microsurgery 2019 Apr 19. Epub 2019 Apr 19.

Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg, Ludwigshafen, Germany.

Background: The aim of this study was to evaluate outcome and safety of free flaps to the upper extremity by pooled, summarized rates, compared with the existing pooled results of the lower extremity from literature, and to improve the level of evidence in a meta-analysis.

Methods: A literature search of PubMed and Embase was conducted addressing publications between January 2000 and April 2018. Publications were selected by inclusion/exclusion criteria on safety and outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/micr.30460
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http://dx.doi.org/10.1002/micr.30460DOI Listing
April 2019
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Activity of a Synthetic Peptide Targeting MgtC on Intramacrophage Survival and Biofilm Formation.

Front Cell Infect Microbiol 2019 2;9:84. Epub 2019 Apr 2.

Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université Montpellier, Montpellier, France.

Antivirulence strategies aim to target pathogenicity factors while bypassing the pressure on the bacterium to develop resistance. The MgtC membrane protein has been proposed as an attractive target that is involved in the ability of several major bacterial pathogens, including , to survive inside macrophages. In liquid culture, MgtC acts negatively on biofilm formation. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00084
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http://dx.doi.org/10.3389/fcimb.2019.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454036PMC
April 2019
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Reducing inappropriate outpatient antibiotic prescribing: normative comparison using unblinded provider reports.

BMJ Open Qual 2019 13;8(1):e000351. Epub 2019 Feb 13.

Center for Healthcare Innovation, Ochsner Health System, New Orleans, Louisiana, USA.

Importance: Antibiotic resistance is a global health issue. Up to 50% of antibiotics are inappropriately prescribed, the majority of which are for acute respiratory tract infections (ARTI).

Objective: To evaluate the impact of unblinded normative comparison on rates of inappropriate antibiotic prescribing for ARTI. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440589PMC
February 2019

The prevalence of and multidrug resistant in healthy captive ophidian.

PeerJ 2019 12;7:e6706. Epub 2019 Apr 12.

Department of Veterinary Science, University of Parma, Parma, Italy.

Background: Snakes are globally considered as pet animals, and millions of ophidians are bred in captivity. is a ubiquitous Gram-negative bacterium that can act as an opportunistic pathogen of man and animals and is frequently present in the oral and cloacal microbiota of healthy ophidians. It can cause severe clinical diseases and often shows antibiotic resistance. Read More

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https://peerj.com/articles/6706
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http://dx.doi.org/10.7717/peerj.6706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463849PMC
April 2019
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Phosphoproteome analysis of cells infected with adapted and non-adapted influenza A virus reveals novel pro- and antiviral signaling networks.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, 35392 Giessen (Germany), Member of the German Center for Lung Research

Influenza A viruses (IAVs) quickly adapt to new environments and are well known to cross species barriers. To reveal a molecular basis for these phenomena, we compared the Ser/Thr and Tyr phosphoproteomes of murine lung epithelial cells early and late after infection with mouse-adapted SC35M virus or its non-adapted SC35 counterpart. With this analysis we identified a large set of upregulated Ser/Thr phosphorylations common to both viral genotypes, while Tyr phosphorylations showed little overlap. Read More

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http://dx.doi.org/10.1128/JVI.00528-19DOI Listing

Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next Generation Vaccine Candidate.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Enterovirus A71 (EV-A71) is the major pathogen which causes hand-foot-and-mouth disease (HFMD) which occasionally results in severe neurological complications. In this study, we developed four EV-A71 (rgEV-A71) strains by reverse genetics procedures as possible vaccine candidates. The four rgEV-A71 viruses contained various codon deoptimized VP1 capsid protein (VP1-CD) showed similar replication rate and antigenicity to wild-type virus, while a fifth virus, rg4643C4VP-CD, was unable to form plaques, but was still able to examined by TCID50 titers which were similar to the others, thus indicating the effect of CD on plaque formation. Read More

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http://dx.doi.org/10.1128/JVI.02308-18DOI Listing
April 2019
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Dual RNA-seq of Xanthomonas oryzae pv. oryzicola infecting rice reveals novel insights into bacterial-plant interaction.

PLoS One 2019 17;14(4):e0215039. Epub 2019 Apr 17.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning Guangxi, China.

The Gram-negative bacterium Xanthomonas oryzae pv. oryzicola (Xoc) is the causal agent of rice bacterial leaf streak (BLS), one of the most destructive diseases of rice (Oryza sativa L.) that is the important staple crop. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215039PLOS

Changing epidemiology of meticillin-resistant in 42 hospitals in the Dutch-German border region, 2012 to 2016: results of the search-and-follow-policy.

Euro Surveill 2019 Apr;24(15)

University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, Netherlands.

IntroductionMeticillin-resistant (MRSA) is a major cause of healthcare-associated infections.AimWe describe MRSA colonisation/infection and bacteraemia rate trends in Dutch-German border region hospitals (NL-DE-BRH) in 2012-16.MethodsAll 42 NL-DE BRH (8 NL-BRH, 34 DE-BRH) within the cross-border network EurSafety Health-net provided surveillance data (on average ca 620,000 annual hospital admissions, of these 68. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1800244DOI Listing

The Interaction of Infection and Type 2 Diabetes Mellitus.

Adv Biomed Res 2019 27;8:15. Epub 2019 Feb 27.

Department of Biochemistry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. Read More

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http://dx.doi.org/10.4103/abr.abr_37_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425747PMC
February 2019
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Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial.

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Service of Infectious Diseases, Hopitaux Universitaires de Geneve, Geneva, Switzerland

Objective: The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.

Methods: We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215116DOI Listing
April 2019
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Circulating growth/differentiation factor 15 is associated with human CD56 natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

EBioMedicine 2019 Apr 13. Epub 2019 Apr 13.

Department of Orthopedics and Trauma Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

Background: Systemic inflammation induced by sterile or infectious insults is associated with an enhanced susceptibility to life-threatening opportunistic, mostly bacterial, infections due to unknown pathogenesis. Natural killer (NK) cells contribute to the defence against bacterial infections through the release of Interferon (IFN) γ in response to Interleukin (IL) 12. Considering the relevance of NK cells in the immune defence we investigated whether the function of NK cells is disturbed in patients suffering from serious systemic inflammation. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.018DOI Listing

Monomorium ant is a carrier for pathogenic and potentially pathogenic bacteria.

BMC Res Notes 2019 Apr 16;12(1):230. Epub 2019 Apr 16.

Crop & Environment Sciences, Harper Adams University, Edgmond, Newport, TF10 8NB, UK.

Objectives: Household ants are regarded as a major household pest and their close association with microorganisms and people means that they may constitute a disease risk. Our study is the first to provide information on the pathogenicity of Monomorium spp. a common insect in Kuwait by quantifying and identifying the exoskeleton bacterial burden. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4266-4DOI Listing
April 2019
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Seroprevalence and risk factors of Toxoplasma gondii among pregnant women in Adwa district, northern Ethiopia.

BMC Infect Dis 2019 Apr 16;19(1):327. Epub 2019 Apr 16.

Department of Public Health, College of Health Sciences, Aksum University, Aksum, Ethiopia.

Background: Toxoplasma gondii infection is a great health concern to pregnant women and the developing fetus. The aim of this study was to determine the seroprevalence of T. gondii and its associated factors in Adwa district. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3936-0DOI Listing
April 2019
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RNAi of the sesquiterpene cyclase gene for phytoalexin production impairs pre- and post-invasive resistance to potato blight pathogens.

Mol Plant Pathol 2019 Apr 16. Epub 2019 Apr 16.

Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, 464-8601, Japan.

Potato antimicrobial sesquiterpenoid phytoalexins lubimin and rishitin have been implicated in resistance to the late blight pathogen, Phytophthora infestans and early blight pathogen, Alternaria solani. We generated transgenic potato plants in which sesquiterpene cyclase, a key enzyme for production of lubimin and rishitin, is compromised by RNAi to investigate the role of phytoalexins in potato defence. The transgenic tubers were deficient in phytoalexins and exhibited reduced post-invasive resistance to an avirulent isolate of P. Read More

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http://dx.doi.org/10.1111/mpp.12802DOI Listing
April 2019
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Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Neutrophils rapidly migrate to infection sites after the recognition of invaders. During chemotaxis, neutrophils require energy supplied by mitochondria oxidative phosphorylation (OXPHOS), whereas neutrophils rely heavily on glycolysis under normal conditions. Mitochondrial OXPHOS correlates with mitochondrial morphology. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.037DOI Listing

Monitoring Your institution: the WHO Hand Hygiene self-assessment Framework - is it worth it?

Clin Microbiol Infect 2019 Apr 12. Epub 2019 Apr 12.

Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland. Electronic address:

This year, the World Health Organization is launching a global survey with self-assessment tools in Infection Prevention and Control and Hand Hygiene. Despite evidence for the effectiveness of hand-hygiene, HCWs' compliance is unacceptably low. It is important to understand the relevance of these tools and their value to institutions and health systems. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193016
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http://dx.doi.org/10.1016/j.cmi.2019.04.009DOI Listing
April 2019
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Orthopaedic Injury Profiles in Methamphetamine Users: A Retrospective Observational Study.

J Am Acad Orthop Surg 2019 Apr 11. Epub 2019 Apr 11.

From the Keck School of Medicine of the University of Southern California, Los Angeles, CA.

Introduction: We sought to characterize the prevalence of methamphetamine (MA) abuse and associated orthopaedic injury patterns at our level 1 trauma center.

Methods: We conducted a retrospective review of all orthopaedic consults for the year 2016. Patients were classified as MA users based on urine toxicology results and social history. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00618DOI Listing

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.

Biomed Res Int 2019 11;2019:3102414. Epub 2019 Mar 11.

Department of Nursing, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan.

Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). Read More

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https://www.hindawi.com/journals/bmri/2019/3102414/
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http://dx.doi.org/10.1155/2019/3102414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432734PMC
March 2019
2 Reads

Knowledge and practices of primary health care physicians regarding updated guidelines of MERS-CoV infection in Abha city.

J Family Med Prim Care 2019 Feb;8(2):455-461

Department of Family Medicine, Ministry of Health, Abha, KSA.

Background: Human coronaviruses (hCoV) usually cause mild to moderate upper respiratory tract illnesses. The novel coronavirus (nCoV), or Middle East respiratory syndrome coronavirus (MERS-CoV), is a particular strain different from any other known hCoV with the possibility of human and also zoonotic transmissions. The aim of the study to assess primary health care (PHC) physicians' knowledge and adherence regarding Saudi Ministry of Health guidelines regarding MERS-CoV. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_336_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436268PMC
February 2019
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IgA and FcαRI: Pathological Roles and Therapeutic Opportunities.

Front Immunol 2019 22;10:553. Epub 2019 Mar 22.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Amsterdam, Netherlands.

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces. The production of IgA exceeds the production of all other antibodies combined, supporting its prominent role in host-pathogen defense. IgA closely interacts with the intestinal microbiota to enhance its diversity, and IgA has a passive protective role via immune exclusion. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00553
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http://dx.doi.org/10.3389/fimmu.2019.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448004PMC
March 2019
2 Reads

Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter.

Front Microbiol 2019 28;10:625. Epub 2019 Mar 28.

School of Life Sciences, Ningxia University, Yinchuan, China.

Enterovirus 71 (EV71), the etiological agent of hand-foot-and-mouth disease, has become an increasing public health challenge worldwide. Accumulating evidence suggests that mammalian microRNAs (miRNAs), a class of non-coding RNAs of 18 to 24 nucleotides (nt) with important regulatory roles in cellular processes, participate in host antiviral defense and studies have suggested roles of miRNAs in EV71 replication and pathogenesis. In the current study, we reported that the expression of hsa-miR-17∼92 cluster was significantly downregulated during EV71 infection. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00625
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http://dx.doi.org/10.3389/fmicb.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447709PMC
March 2019
2 Reads

Necrotizing Infection of the Upper Extremity: A Veterans Affairs Medical Center Experience (2008-2017).

Fed Pract 2019 Mar;36(3):140-144

is a Plastic and Hand Surgeon, and is an Advanced Registered Nurse Practitioner, both at the Malcom Randall VA Medical Center in Gainesville, Florida. Loretta Coady-Fariborzian is a Clinical Associate Professor at the University of Florida in Gainesville.

Necrotizing infection of the upper extremity is a rare pathology with a substantial risk of amputation and mortality that requires a high index of suspicion and expeditious referral to a hand surgeon. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453610PMC

Prospective Analysis of Hand Infection Rates in Elective Soft Tissue Procedures of the Hand: The Role of Preoperative Antibiotics.

Hand (N Y) 2019 Apr 15:1558944719842238. Epub 2019 Apr 15.

2 The George Washington University Hospital, Washington, DC, USA.

Background: The purpose of this study was to evaluate the efficacy of prophylactic antimicrobial prophylaxis in elective hand surgery in preventing postoperative infection.

Methods: Between 2009 and 2012, we performed a multicenter trial in which patients undergoing elective hand surgeries were categorized into an antibiotic or control group depending on the center they were enrolled in. Surgical site infections were defined according to the Centers for Diseases Control and Prevention. Read More

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http://dx.doi.org/10.1177/1558944719842238DOI Listing
April 2019
1 Read

[Risk of zoonoses by animal bites and scratches].

Rev Prat 2019 Mar;69(3):320-323

Ancien professeur en pathologie infectieuse, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes-Atlantique, Oniris, Nantes, France.

Risk of zoonoses by animal bites and scratches. The objectives of this study are to identify zoonosis risks related to animal bites and scratches in France. Pet-transmitted zoonoses, as pasteurellosis, cat scratches disease and various specific bacterial infections, are predominant, resulting usually in localized infections or, sometimes, in serious systemic infections (as those caused by Capnocytophaga canimorsus) in immunocompromised patients. Read More

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March 2019
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[Malaria prevention].

Authors:
Olivier Bouchaud

Rev Prat 2019 Feb;69(2):166-170

Service des maladies infectieuses et tropicales, hôpital Avicenne (AP-HP), Université Paris-13, Bobigny, France.

Malaria prevention. Due to the huge difference in risk of infection between tropical Asia and America on the one hand and sub-saharan Africa on the other (ratio of 1 to 1000) and lack of transmission of Plasmodium falciparum in Asia and tropical America, it is now recommended to no longer prescribe chemoprophylaxis in these low-risk areas in the vast majority of cases (conventional stays), retaining the simple adage: Sub-Saharan Africa yes, elsewhere no ! In any case, travelers should be advised to limit the mosquito bites at night (especially repellents but also mosquito nets impregnated and impregnation of clothing) and to signal the tropical stay in case of fever at the return. African migrants being the main target of imported malaria should be informed of the importance of this prevention. Read More

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February 2019
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[Repair of skin and soft tissue defects in extremities with the superior lateral genicular artery perforator flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):467-470

Department of Hand and Microsurgery, Xiangya Hospital, Central South University, Changsha Hunan, 410008, P.R.China.

Objective: To investigate the feasibility and effectiveness of the superior lateral genicular artery perforator flap for repairing of soft tissue defects in extremities.

Methods: Between September 2010 and October 2017, 11 cases of skin and soft tissue in extremities were repaired with the superior lateral genicular artery perforator flap. There were 10 males and 1 female, with an average age of 37. Read More

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http://dx.doi.org/10.7507/1002-1892.201811103DOI Listing
April 2019
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A case of cutaneous nodules in a sporotrichoid pattern.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology and Venereology, Centro Hospitalar Universitário de São João EPE, Porto.

A sporotrichoid pattern describes a clinical presentation in which inflammatory nodules spread along the path of lymphatic drainage, being reported in association with several infectious, neoplastic, and inflammatory skin conditions. Herein, we report a 65-year-old man presenting with a three-month history of erythematous nodules in a linear distribution along the left hand and forearm. He reported recent rose gardening and regular contact with an aquarium. Read More

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March 2019
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[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
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[Prevention of infectious diseases in patients with chronic renal failure].

Authors:
Jean-Ralph Zahar

Nephrol Ther 2019 Apr;15 Suppl 1:S21-S26

Unité de contrôle et de prévention du risque infectieux, service de microbiologie, groupe hospitalier universitaire, hôpital Avicenne, Paris Seine Saint-Denis, 125, rue de Stalingrad, 93000 Bobigny, France; UFR-SMBH, université Paris XIII, Paris Sorbonne, 125, rue de Stalingrad, 93000 Bobigny, France. Electronic address:

The patient followed in nephrology ward for a glomerulopathy is exposed throughout his illness, into the hospital as in the community, at a high risk of bacterial, viral and more and more frequently fungal infections. At each stage of his illness, given the comorbidities associated with his renal pathology, the immunosuppressive treatments administered and the chronic haemodialysis and renal transplantation in the event of progressive disease, the nephrological patient requires specific management. Prevention consists on one hand to limit as much as possible infectious risks in the community by improving its vaccination coverage before, during and after the renal transplant and by limiting urinary infections which can worsen the underlying disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193004
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http://dx.doi.org/10.1016/j.nephro.2019.03.004DOI Listing
April 2019
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The rash with maculopapules and fever in children.

Clin Dermatol 2019 Mar - Apr;37(2):119-128. Epub 2018 Dec 5.

Dermatology Department, University of CT Health Center, Farmington, Connecticut, USA. Electronic address:

Several medical conditions can cause children to present with fever and a maculopapular rash Although some presentations are benign, others may be medical emergencies, which warrant a prompt diagnosis. We review some of the more common causes of fever and maculopapular dermatitirs, rash including infectious processes (roseola; rubeola; rubella; parvovirus B19; hand, foot, and mouth disease; scarlet fever; meningococcemia; Epstein-Barr virus infection), hypersensitivity reactions (exanthematous drug reactions), and vasculitis syndromes (Kawasaki disease). We have included a diagnostic algorithm to facilitate rapid identification of the etiology of the rash and fever. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.005DOI Listing
December 2018
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Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection.

J Neuroinflammation 2019 Apr 13;16(1):86. Epub 2019 Apr 13.

Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W. Olney Road, Lewis Hall 3174, Norfolk, VA, 23501, USA.

Background: Impairment of the blood-brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role for the Sonic hedgehog (Shh) signaling pathway in the maintenance of BBB integrity under both physiological and pathological conditions.

Methods: In the present study, we sought to examine the expression of Shh and its downstream effectors in relation to brain pericytes and BBB integrity in HIV-infected humans and rhesus macaques infected with simian immunodeficiency virus (SIV), an animal model of HIV infection and CNS disease. Read More

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http://dx.doi.org/10.1186/s12974-019-1463-yDOI Listing
April 2019
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PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.

Mol Biol Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Public Health and Pediatric Sciences, University of Turin, Via Santena 9, 10126, Turin, Italy.

The aim of the present study is to determine the expression levels of PYHIN (IFI16 and AIM2) and APOBEC3 (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) gene family members in a cohort of patients with head and neck squamous cell carcinoma (HNSCC) and assess their potential correlation with human papillomavirus (HPV) infection status, clinical characteristics, and survival. For this purpose, 34 HNSCC tissue specimens along with healthy surrounding mucosa were collected from patients surgically treated for HNSCC. Nucleic acids were isolated to assess the presence of HPV and the expression levels of selected molecular markers. Read More

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http://dx.doi.org/10.1007/s11033-019-04795-7DOI Listing
April 2019
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[Smoking, alcohol and diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

5. Medizinische Abteilung für Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Wien, Österreich.

Smoking and second-hand smoke strongly increase incidence of diabetes and probability for its complications. Smoking cessation can lead to weight gain and increased diabetes risk; however, it decreases cardiovascular and total mortality. A basal diagnostics (Fagerström Test, exhaled CO) is the basis for successful smoking cessation. Read More

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http://link.springer.com/10.1007/s00508-019-1455-z
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http://dx.doi.org/10.1007/s00508-019-1455-zDOI Listing
April 2019
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Multidrug-resistant Organisms in Hospitals: What Is on Patient Hands and in Their Rooms?

Clin Infect Dis 2019 Apr 13. Epub 2019 Apr 13.

Division of Infectious Diseases, Henry Ford Health System, Detroit, Michigan.

Background: The impact of healthcare personnel hand contamination in multidrug-resistant organism (MDRO) transmission is important and well studied; however, the role of patient hand contamination needs to be characterized further.

Methods: Patients from 2 hospitals in southeast Michigan were recruited within 24 hours of arrival to their room and followed prospectively using microbial surveillance of nares, dominant hand, and 6 high-touch environmental surfaces. Sampling was performed on admission, days 3 and 7, and weekly until discharge. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz092DOI Listing
April 2019
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Hygiene During Childbirth: An Observational Study to Understand Infection Risk in Healthcare Facilities in Kogi and Ebonyi States, Nigeria.

Int J Environ Res Public Health 2019 Apr 11;16(7). Epub 2019 Apr 11.

Disease Control Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

: Infections acquired during labour and delivery are a significant cause of maternal and child morbidity and mortality. Adherence to hand hygiene protocols is a critical component of infection prevention strategies, but few studies have closely examined the hand hygiene of health care providers with sufficient detail to understand infection risks and prioritize prevention strategies. : This observational study was conducted in six healthcare facilities in Nigeria. Read More

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https://www.mdpi.com/1660-4601/16/7/1301
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http://dx.doi.org/10.3390/ijerph16071301DOI Listing
April 2019
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Whole genome characterization of feline-like G3P[8] reassortant rotavirus A strains bearing the DS-1-like backbone genes detected in Vietnam, 2016.

Infect Genet Evol 2019 Apr 9;73:1-6. Epub 2019 Apr 9.

Department of Hygiene and Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

While conducting rotavirus gastroenteritis surveillance in Vietnam, two G3P[8] rotavirus A specimens possessing an identical short RNA electropherotype were detected. They were RVA/Human-wt/VNM/0232/2016/G3P[8] and RVA/Human-wt/VNM/0248/2016/G3P[8], and recovered from 9 and 23 months old boys, respectively. The patients developed diarrhoea within one-week interval in March 2016 but in places >100 km apart in northern Vietnam. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.007DOI Listing
April 2019
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Effective long-term control of Echinococcus multilocularis in a mixed rural-urban area in southern Germany.

PLoS One 2019 12;14(4):e0214993. Epub 2019 Apr 12.

Holzhofer Flight Service, Boxberg, Germany.

Effective preventive strategies are available to control Echinococcus multilocularis in foxes in order to reduce the human infection risk. Reduction of E. multilocularis prevalence in foxes was achieved in various studies by distributing praziquantel-containing bait by hand or by aircraft in either rural or settlement areas. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214993PLOS

Infection after spinal surgery and procedures.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):173-178

Department of Orthopaedics and Trauma Surgery, University Campus Bio-Medico of Rome, Rome, Italy.

Postoperative infections after spinal surgery are a challenging issue, difficult to diagnose and treat, that requires prolonged medical therapy and even surgery. In this paper, we aim to review the current standards in the diagnosis and treatment of post-procedural Spondylodiscitis (SD). We performed a review of the available literature focusing on diagnostic and therapeutic standards of post-procedural SD, both after minimally invasive procedures and open surgery. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17487DOI Listing
April 2019
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Two-stage reimplantation in periprosthetic knee infection.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):51-58

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy

Objective: The increasing number of total knee arthroplasties performed yearly worldwide has resulted in a concomitant rise in bacterial infections. Two-stage reimplantation has been reported as the most successful method of treating periprosthetic knee infections. The purpose of this study was to describe all the phases of the two-stage reimplantation and to review the literature regarding the topic. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17474DOI Listing
April 2019
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The use of custom-made antibiotic-loaded spacer in periprosthetic knee infection caused by XDR organism: case report and review of literature.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):19-25

Department of Aging, Orthopedics and Rehabilitation; Institute of Orthopedics, Traumatology and Spine Surgery, Fondazione Policlinico Agostino Gemelli - IRCCS, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Periprosthetic knee infection (PKI) remains one of the most challenging complications after total knee replacement, especially if caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) organisms. Multiple treatment options are available, such as long-term antibiotic suppression, surgical debridement with retention of the prosthesis, definitive resection arthroplasty, arthrodesis, one-stage or two-stage revision procedures, amputation. We present a rare case of a PKI caused by a XDR Klebsiella pneumoniae in a young patient who underwent a prosthetic reconstruction due to an osteosarcoma of the tibia. Read More

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http://www.europeanreview.org/article/17470
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http://dx.doi.org/10.26355/eurrev_201904_17470DOI Listing
April 2019
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Do liquid wastes from automated instruments in medical laboratories have their proper microbicide effect?

Ann Biol Clin (Paris) 2019 Apr 12. Epub 2019 Apr 12.

Laboratoire de virologie, Institut des agents infectieux, Groupement Hospitalier Nord des Hospices civils de Lyon, Lyon, France, Institut des sciences biologiques et pharmaceutiques de Lyon, Université Claude Bernard Lyon 1, Lyon, France, CIRI, Centre international de recherche en infectiologie, Équipe Virpath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École normale supérieure de Lyon, Lyon, France.

Liquid wastes from clinical biology automated systems are currently evacuated in the urban network after chemical treatment to eliminate a possible risk of infection. Since these wastes are ecotoxic because of the presence of numerous chemical reagents, we studied their intrinsic microbicidal power towards a selection of infectious agents widely found in clinical specimens. The objective was to determine if an additional anti-infectious treatment before elimination is necessary. Read More

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http://dx.doi.org/10.1684/abc.2019.1431DOI Listing
April 2019
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