448,415 results match your criteria Hand Infections


Porcine-Derived Biomaterials in Tissue Engineering and Reconstructive Surgery: Considerations and Alternatives in Muslim Patients.

J Tissue Eng Regen Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Plastic Surgery, Hand Surgery and Burn Centre, Faculty of Medicine, RWTH University Hospital, Aachen, Germany.

During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone, or in combination with cultured cellular products, have been introduced to compensate for the scarcity of autologous donor tissue or to improve healing in a variety of surgical specialties e.g. Read More

View Article
December 2018

Effect of model race and viewing perspective on body attractiveness and body size assessment in young Caucasian women: an eye-tracking study.

Psychol Res 2018 Dec 15. Epub 2018 Dec 15.

School of Psychology, University of Lincoln, Brayford Pool, Lincoln, LN6 7TS, UK.

Research has indicated that Caucasian women gaze more often at waist-hip and chest regions than other local body areas when assessing female body attractiveness and body size, and this stereotypical gaze distribution is further modulated by their own body satisfaction and body composition. However, little is known whether the model race and viewing perspective could affect women's body-viewing gaze behaviour and body perception. Here, we presented female body images of Caucasian, Asian and African avatars in a continuum of common dress sizes in full frontal, mid-profile and rear view, and asked young Caucasian women to rate the perceived body attractiveness and body size. Read More

View Article
December 2018

Illumina MiSeq Sequencing Investigation of Microbiota in Bronchoalveolar Lavage Fluid and Cecum of the Swine Infected with PRRSV.

Curr Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology, College of Life Science and Technology, Dalian University, Dalian, 116622, Liaoning, China.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide. In this study, we analyzed the microbiota in bronchoalveolar lavage fluid (BAL), mucosa, and feces in cecum of the PRRSV-challenged pigs using the Illumina MiSeq sequencing platform, to investigate the role of microbiota in the pathogenesis and development of porcine reproductive and respiratory syndrome (PRRS). Quantitative insights into microbial ecology analyses indicated that the dominant bacterial groups in the lung from the PRRSV-challenged pigs were Haemophilus parasuis and Mycoplasma hyorhinis, with a relative abundance of 35-48% and 27-41%, respectively. Read More

View Article
December 2018
1 Read

Comparative analysis of intracellular metabolites, proteins and their molecular functions in a flor yeast strain under two enological conditions.

World J Microbiol Biotechnol 2018 Dec 15;35(1). Epub 2018 Dec 15.

Department of Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence ceiA3, University of Córdoba, Córdoba, Spain.

Flor yeasts confer a wide range of organoleptic properties to Sherry-type wines during a process called "biological aging" that takes place after alcoholic fermentation. These kinds of yeasts adapt to a biological aging condition by forming a biofilm known as "flor velum" and by changing from fermentative to oxidative metabolism. It has been reported that some functions such as increase of cell surface hydrophobicity or changes to lipid metabolism are enhanced when yeasts switch to biofilm lifestyle. Read More

View Article
December 2018

Guidelines, good practices and best clinical health practices: valuable guidance for physicians and judges?

Clin Ter 2018 Nov-Dec;169(6):e292-e296

Dipartimento di Scienze anatomiche, istologiche, medico-legali e dell'apparato locomotore, Sezione di Medicina legale, Università "Sapienza" di Roma.

Enactment of law n. 24, 8th March 2017, (so-called "Gelli-Bianco" law), has given rise to substantial innovations in the realm of medical liability: on the one hand, an attempt has been made towards redefining the boundaries of professional liability, for the purpose of curbing the use of "defensive medicine"; on the other hand, there is the effort to delineate good medical conduct by means of "institutionalization" and a greater degree of consistency of guidelines and good clinical health care practices. There are, however, thought-provoking cues concerning the relationship between the two concepts, which can be sensibly developed, even in light of international scientific literature. Read More

View Article
December 2018

Strategies to control antibiotic resistance: results from a survey in Italian children's hospitals.

Ann Ig 2019 Jan-Feb;31(1):3-12

Medical Direction, Bambino Gesù Children's Hospital, Rome, Italy.

Background: Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance.

Study Design: Cross sectional multicenter study. Read More

View Article
December 2018

Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease.

Nephron 2018 Dec 14:1-9. Epub 2018 Dec 14.

Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.

Background/aims: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). Read More

View Article
December 2018

Longitudinal Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System (TOMS).

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Paris 6, Sorbonne Universités, GRC-08 (EEMOIS); AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital, Paris, France; Spire Sciences Inc., Boca Raton, Florida; Data and Statistical Sciences, and Immunology Development, AbbVie Inc., North Chicago, Illinois; Departments of Radiology and Medicine, University of California at San Francisco, San Francisco, California; AbbVie Inc., Cambridge, Massachusetts, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research, Leeds Biomedical Research Centre, Leeds, UK; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. PGC is supported in part by the UK National Institute for Health Research infrastructure at Leeds. F.P. Kroon, MD, Department of Rheumatology, Leiden University Medical Center; S. van Beest, MD, Department of Rheumatology, Leiden University Medical Center; F. Gandjbakhch, MD, Practicing Rheumatologist, Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital; C.G. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; S. Chen, Data and Statistical Sciences, AbbVie Inc.; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research, Leeds Biomedical Research Centre; I. Eshed, MD, Associate Professor of Radiology, Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University; V. Foltz, MD, Practicing Rheumatologist, Paris 6, Sorbonne Universités, GRC-08 (EEMOIS), and AP-HP, Department of Rheumatology, Pitié Salpêtrière University Hospital; H.K. Genant, MD, FACR, FRCR, Professor Emeritus of Radiology, Medicine and Orthopedics, Departments of Radiology and Medicine, University of California at San Francisco; I.K. Haugen, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; J.K. Medema, MS, Senior Project Leader, Immunology Development, AbbVie Inc.; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, and Department of Clinical Medicine, University of Copenhagen; L. Zhang, Data and Statistical Sciences, AbbVie Inc.; M.C. Levesque, MD, PhD, Foundational Immunology Senior Director, AbbVie Inc.; M. Kloppenburg, MD, PhD, Professor of Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center. Address correspondence to Dr. F.P. Kroon, Department of Rheumatology, Leiden University Medical Center, Post Box 9600, 2300 RC Leiden, the Netherlands. E-mail: Accepted for publication November 7, 2018.

Objective: To assess the longitudinal reliability of the Outcome Measures in Rheumatology (OMERACT) Thumb base Osteoarthritis Magnetic resonance imaging (MRI) Scoring system (TOMS).

Methods: Paired MRI of patients with hand osteoarthritis were scored in 2 exercises (6-mo and 2-yr followup) for synovitis, subchondral bone defects (SBD), osteophytes, cartilage assessment, bone marrow lesions (BML), and subluxation. Interreader reliability of delta scores was assessed. Read More

View Article
December 2018

Risk factors for childhood violence and polyvictimization: A cross-country analysis from three regions.

Child Abuse Negl 2018 Dec 13;88:348-361. Epub 2018 Dec 13.

UNICEF Office of Research-Innocenti, Piazza SS Annunziata 12, 50121, Florence, Italy.

Understanding risk factors is important to ending childhood violence and meeting Sustainable Development Goal 16.2. To date, no study has examined patterns of risk factors across countries comprehensively for different types of childhood violence, and there is a dearth of evidence of polyvictimization in lower- and middle-income settings. Read More

View Article
December 2018
1 Read

A hierarchical machine learning classification approach for secondary task identification from observed driving behavior data.

Accid Anal Prev 2018 Dec 13;123:274-281. Epub 2018 Dec 13.

Department of Civil and Environmental Engineering, University of Alabama, Huntsville, AL 35899, United States. Electronic address:

According to NHTSA, more than 3477 people (including 551 non-occupants) were killed and 391,000 were injured due to distraction-related crashes in 2015. The distracted driving epidemic has long been under research to identify its impact on driving behavior. There have been a few attempts to detect drivers' engagement in secondary tasks from observed driving behavior. Read More

View Article
December 2018

Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP.

J Magn Reson 2018 Dec 7;299:28-32. Epub 2018 Dec 7.

Universidad Nacional de Córdoba, Facultad de Matemática, Atronomía, Física y Computación, Córdoba, Argentina; CONICET, Instituto de Física Enrique Gaviola (IFEG), Córdoba, Argentina.

Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presence of a large amount of non-reacted molecules with thermal polarization is an important obstacle when dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution in a single experiment by combining two well established pulse sequences, OPSY and PHD-PHIP is presented. OPSY is used as a block for filtering the signals originated from thermally polarized protons. Read More

View Article
December 2018

Hand-over.

Authors:
Christophe Meyer

J Stomatol Oral Maxillofac Surg 2018 Dec 13. Epub 2018 Dec 13.

University Hospital of Besançon, Department of stomatology, maxillofacial surgery and hospital dentistry, boulevard Fleming, 25030 Besançon cedex, France. Electronic address:

View Article
December 2018

Biodegradation of Cibacron Blue 3GA by insolubilized laccase and identification of enzymatic byproduct using MALDI-ToF-MS: Toxicity assessment studies by Daphnia magna and Chlorella vulgaris.

Ecotoxicol Environ Saf 2018 Dec 13;170:453-460. Epub 2018 Dec 13.

Biochemical Processing and Biomaterial Research Laboratory, Gazi University, 06500 Teknikokullar, Ankara, Turkey.

The presented paper describes a detailed study on the use of immobilized laccase for effective degradation of Cibacron Blue 3GA dye. The amount of laccase loading on the cyclic carbonate groups containing poly(hydroxyethyl methacrylate-co-vinylene carbonate), p(HEMA-co-VC), microbeads was 27.8 mg g, and the retained immobilized enzyme activity was 73% compared to free enzyme. Read More

View Article
December 2018

Potential and constraints for the application of CFD combined with Lagrangian particle tracking to dry powder inhalers.

Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Multiphase Flow Systems (MPS), Institute of Process Engineering, Otto-von-Guericke-University (OvGU) Magdeburg, Zeppelinstraße 1, D-06130 Halle (Saale), Germany.

For about 15 years the performance of dry powder inhalers (DPIs) has been numerically analysed through CFD (computational fluid dynamics) approaches with the objective of understanding the evolving flow structures and the resulting transport of drug particles. Naturally the main interest is the numerical prediction of the emitted fine particle fraction (FPF) which is able to penetrate the lung airways. Due to the mostly used drug formulations (i. Read More

View Article
December 2018

Acute Vibration Induces Peripheral Nerve Sensitization in a Rat Tail Model: Possible Role of Oxidative Stress and Inflammation.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, 26501, United States. Electronic address:

Prolonged occupational exposure to hand-held vibrating tools leads to pain and reductions in tactile sensitivity, grip strength and manual dexterity. The goal of the current study was to use a rat-tail vibration model to determine how vibration frequency influences factors related to nerve injury and dysfunction. Rats were exposed to restraint, or restraint plus tail vibration at 62. Read More

View Article
December 2018

Bi-directional drug-microbiome interactions of anti-diabetics.

EBioMedicine 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine- Molecular Medicine, Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

Type 2 diabetes (T2D) has become a global epidemic. Although several drugs are available to manage T2D, problems associated with person-to-person variability in drug efficacy and potential side-effects remain unresolved. Owing to the emerging role of the gut microbiome in obesity and T2D, the interaction between gut microbes and anti-diabetic drugs and its influence on drugs' functions remains of immediate research interest. Read More

View Article
December 2018

Higher symptom burden is associated with lower function in women taking adjuvant endocrine therapy for breast cancer.

J Geriatr Oncol 2018 Dec 12. Epub 2018 Dec 12.

Medical Oncology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address:

Objective: To explore the impact of symptoms on physical function in women on adjuvant endocrine therapy for breast cancer.

Methods: Eligible women were postmenopausal, had hormone receptor positive, stage I-IIIA breast cancer, completed surgery, chemotherapy, radiation, and on adjuvant endocrine therapy. At a routine follow-up visit, women (N = 107) completed standardized symptom measures: Brief Fatigue Inventory, Brief Pain Inventory, Menopause Specific Quality of Life Questionnaire, Functional Assessment of Cancer Therapy Neurotoxicity scales. Read More

View Article
December 2018

Reading the palm with MUNIX: A 'reversed split hand' in spinal muscular atrophy.

Authors:
Michael Swash

Clin Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Barts and the London School of Medicine, QMUL, London, UK; Institute of Neuroscience, University of Lisbon, Portugal. Electronic address:

View Article
December 2018

Towards viscoelastic characterisation of the human ulnar nerve: An early assessment using embalmed cadavers.

Med Eng Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Anatomy, College of Medical and Dental Sciences, University of Birmingham, United Kingdom. Electronic address:

Cubital tunnel syndrome is the most prevalent neuropathy of the ulnar nerve and its aetiology is controversial. Potential replacement materials should display similar viscoelastic properties. The purpose of this study was to assess the feasibility and merit of quantifying the frequency-dependent viscoelastic properties of proximal and distal sections of the human ulnar nerve. Read More

View Article
December 2018

Sleep safe in clean hands: Improving hand hygiene compliance in the operating room through education and increased access to hand hygiene products.

Am J Infect Control 2018 Dec 12. Epub 2018 Dec 12.

Duke University School of Nursing, Durham, NC.

Background: Hand hygiene compliance is low among anesthesia providers in the operating room, which places patients at risk of preventable infections. The goal of this project was to improve hand hygiene compliance by educating anesthesia providers on the World Health Organization's 5 indications for hand hygiene, and increasing access to hand hygiene products in the operating room.

Methods: Observations of hand hygiene in the operating room took place in 3 phases: preimplementation, postimplementation, and 60 days postimplementation. Read More

View Article
December 2018

l-Theanine and NEP1-40 promote nerve regeneration and functional recovery after brachial plexus root avulsion.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun, 130012, China. Electronic address:

Brachial plexus root avulsion causes severe sequelae Treatments and prognosis face many problems, including inflammatory reaction, oxidative damage, and myelin related inhibitory effect. l-Theanine has anti-inflammatory, anti-oxidative, and neuroprotective effects. NEP1-40 competitively inhibits Nogo-66 receptor (NgR1) promotes axonal regeneration. Read More

View Article
December 2018

Effect of the chemical environment of the DNA guanine quadruplex on the free energy of binding of Na and K ions.

J Chem Phys 2018 Dec;149(22):225102

Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.

Guanine quadruplex (G-quadruplex) structures play a vital role in stabilizing the DNA genome and in protecting healthy cells from transforming into cancer cells. The structural stability of G-quadruplexes is greatly enhanced by the binding of monovalent cations such as Na or K into the interior axial channel. We computationally study the free energy of binding of Na and K ions to two intramolecular G-quadruplexes that differ considerably in their degree of rigidity and the presence or absence of terminal nucleotides. Read More

View Article
December 2018
1 Read

Differential exposure to organophosphate flame retardants in mother-child pairs.

Chemosphere 2018 Dec 4;219:567-573. Epub 2018 Dec 4.

Departmentof Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA. Electronic address:

Background: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

Objectives: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. Read More

View Article
December 2018
2 Reads

Salvanic acid B inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling pathway.

Biomed Pharmacother 2018 Dec 12;110:685-691. Epub 2018 Dec 12.

Department of Cardiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China. Electronic address:

Objective: Salvanic Acid B (Sal B) was proved to show significant effect against fibrosis and myocardial injury. This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis.

Methods: The mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Read More

View Article
December 2018
1 Read

Prescription patterns of direct oral anticoagulants in pulmonary embolism: A prospective multicenter French registry.

Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.

Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.

Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More

View Article
December 2018
1 Read

Reversible hydrogen adsorption on Li-decorated T-graphene flake: The effect of electric field.

J Mol Graph Model 2018 Dec 8;87:192-196. Epub 2018 Dec 8.

Department of Chemistry, College of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

In the present work, we have studied a new allotrope of graphene, denoted as T-graphene (TG) flake as a versatile material in hydrogen storage. Recently, the metallic character of TG has been revealed. Our results show that the Li-decoration has a significant effect on the electronic properties of TG flake. Read More

View Article
December 2018

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology and Biotechnology "Charles Darwin", La Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; Pasteur Institute-Cenci Bolognetti Foundation, Viale Regina Elena, 291, 00100 Rome, Italy.. Electronic address:

Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. Read More

View Article
December 2018

Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning.

Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.

Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University, Japan. Electronic address:

Transcranial static magnetic stimulation (tSMS) is a recently introduced noninvasive brain stimulation technique that can modulate brain excitability. Here, we investigated a hypothesis that motor learning would be altered by tSMS applied to the primary motor cortex (M1). For motor task, we chose a serial reaction time task consisting of sequential trials and random trials in which the visual cue doesn't play out a repeating pattern of positions to evaluate an implicit motor learning, where the M1 is a key structure for skill acquisition and early consolidation. Read More

View Article
December 2018

Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.

J Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In particular, they partner protein thiols in reversible thiol-disulfide exchange reactions that act as switches in cell signaling and redox homeostasis. Disruption of these processes may impair cellular redox signal transduction and induce redox misbalances that are linked directly to aging processes and to a range of pathological conditions including cancer, cardiovascular diseases and neurological disorders. Read More

View Article
December 2018

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

View Article
December 2018
2 Reads

To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

DMedEth RN SFHEA Senior Lecturer University of Birmingham.

Aims And Objectives: To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

Background: End-stage heart failure is associated with significant symptom burden at rest. Left ventricular assist devices are not curative nevertheless they alleviate symptoms and prolong survival. Read More

View Article
December 2018

Tumor Necrosis Factor Related Apoptosis Inducing Ligand reduces the expression of the neuroprotective Na /Ca exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania School of Medicine, Catania, Italy.

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL), a cytokine belonging to the TNF superfamily, is regarded as a mediator of neurotoxicity. The constitutively expressed ion exchanger NCX3 has been shown to protect neurons from injury. Its expression is induced by Nerve growth factor (NGF) through activation of its tyrosine kinase receptor trkA. Read More

View Article
December 2018

Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo.

J Cell Physiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Osteoporosis, arthritis, Peget's disease, bone tumor, periprosthetic joint infection, and periprosthetic loosening have a common characteristic of osteolysis, which is characterized by the enhanced osteoclastic bone resorptive function. At present, the treatment target of these diseases is to interfere with osteoclastic formation and function. Scutellarein (Scu), a flavonoids compound, can inhibit the progress of tumor and inflammation. Read More

View Article
December 2018

Pupil size and search performance in low and high perceptual load.

Authors:
Manuel Oliva

Cogn Affect Behav Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Cognitive Science, Lund University, Lund, Sweden.

The ability to focus on a task while disregarding irrelevant information is an example of selective attention. The perceptual-load hypothesis argues that the occurrence of early or late selection mechanisms is determined by task-relevant perceptual load. Additionally, evidence shows that pupil size serves as proxy of locus coeruleus-norepinephrine (LC-NE) activity, a system associated with cognitive and attentional mediation. Read More

View Article
December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

View Article
December 2018
1 Read

The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

Department of Cancer Genetics, Istanbul Faculty of Medicine, Oncology Institute, Istanbul University, Istanbul, Turkey.

MicroRNAs (miRNAs) have major roles in nearly all cellular process including gene expression, and may behave as oncogene or tumor suppressor gene by binding to complementary sequences in the target mRNA. The circulating microRNA-15a (miRNA-15a) and microRNA-16-1 (miRNA-16-1) of 15 healthy adults and of 40 untreated patients diagnosed with diffuse large B-cell lymphoma (DLBC) were recruited to investigate the expression levels. The expression levels of miRNA-15a, and miRNA-16-1 genes of the untreated DLBCL patients, and healthy individuals with matched age, sex and ethnicity were examined. Read More

View Article
December 2018
1 Read

Polymorphisms in XPC gene and risk for prostate cancer.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.

Single nucleotide polymorphisms (SNP) in repair gene DNA such as XPC gene can reduce the DNA repair capacity (DRC). Reduced DRC induce genetic instability and may increase the susceptibility to prostate cancer (PC). We conducted a case-controls study to examine the relationship between XPC Lys939Gln and XPC-PAT polymorphisms and the risk for prostate cancer in Tunisian population. Read More

View Article
December 2018
1 Read

Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.

Wound healing is a complex orchestration of processes involving cell proliferation, migration, differentiation, anabolism, and catabolism in order to restore skin continuity. Within these processes, elements such as metallic ions are involved due to their implications in cell behavior and enzymatic activity regulation. This study analyzed the kinetics of zinc, iron, copper and magnesium concentrations in a full thickness open wound rat model over 14 days. Read More

View Article
December 2018
1 Read

Sex differences in somatomotor representations of others' pain: a permutation-based analysis.

Brain Struct Funct 2018 Dec 14. Epub 2018 Dec 14.

Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, UCLA, Los Angeles, CA, USA.

Sex differences in empathy for pain have been repeatedly observed. However, it is unclear whether this is due to sex differences in "bottom-up" somatomotor representations of others' pain (self-other resonance) or to "top-down" prefrontal control of such responses. Here, we provide data from 70 subjects suggesting that sex differences in empathy for pain lie primarily in pre-reflective, bottom-up resonance mechanisms. Read More

View Article
December 2018

Use of the myocutaneous serratus anterior free flap for reconstruction after salvage glossectomy.

Eur Arch Otorhinolaryngol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.

Purpose: To describe the use of a myocutaneous serratus anterior free flap (SAFF) for tongue reconstruction after salvage subtotal (STG) and total glossectomy (TG).

Methods: In this prospective case series, seven patients underwent salvage STG or TG and reconstruction with a myocutaneous SAFF between 10/2015 and 02/2017. Functional and oncologic outcomes were prospectively evaluated. Read More

View Article
December 2018
1 Read

High-resolution flat panel CT versus 3-T MR arthrography of the wrist: initial results in vivo.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Objectives: The objective of this study was to compare the diagnostic performance of direct C-arm flat panel computed tomography arthrography (FPCT-A) with direct magnetic resonance arthrography (MR-A) of the wrist in patients with clinically suspected pathologies.

Methods: Forty-nine patients underwent tri-compartmental wrist arthrography. FPCT-A was acquired using a high-resolution acquisition mode, followed by a 3-T MR exam using a dedicated wrist coil. Read More

View Article
December 2018

The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review.

Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More

View Article
December 2018
1 Read

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

View Article
December 2018

Evaluation of new quality indicators for the TraumaRegister DGU using the systematic QUALIFY methodology.

Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.

Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.

Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More

View Article
December 2018
1 Read

Validation of the short version of the Van Lieshout Test in an Italian population with cervical spinal cord injuries: a cross-sectional study.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Public Health and Infection Disease, Sapienza University of Rome, Rome, Italy.

Study Design: Psychometric study.

Objective: To validate the Italian version of the Van Lieshout Test Short Version (VLT-SV) with a spinal cord injury population.

Setting: Three Italian spinal units. Read More

View Article
December 2018

Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

View Article
December 2018
1 Read

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis.

BMJ Open 2018 Dec 14;8(12):e022879. Epub 2018 Dec 14.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Objective: To investigate the efficacy and safety of the pulsed electromagnetic field (PEMF) therapy in treating osteoarthritis (OA).

Design: Meta-analysis.

Data Sources: PubMed, Embase, the Cochrane Library and Web of Science were searched through 13 October 2017. Read More

View Article
December 2018
1 Read

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Immunology Development, AbbVie, North Chicago, Illinois, USA.

Objective: To assess the efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in erosive hand osteoarthritis (HOA).

Methods: Patients with ≥1 erosive and ≥3 tender and/or swollen hand joints were randomised to placebo or lutikizumab 200 mg subcutaneously every 2 weeks for 24 weeks. The primary endpoint was change in Australian/Canadian Osteoarthritis Hand Index (AUSCAN) pain subdomain score from baseline to 16 weeks. Read More

View Article
December 2018

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

EMBO Mol Med 2018 Dec 14. Epub 2018 Dec 14.

MRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Loss-of-function mutations in , a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome oxidase (COX) deficiency. Although the genetic association of APOPT1 pathogenic variants with isolated COX defects is now clear, the biochemical link between APOPT1 function and COX has remained elusive. We investigated the molecular role of APOPT1 using different approaches. Read More

View Article
December 2018
1 Read

Diagnostic sensitivity of electrophysiology and ultrasonography in ulnar neuropathies of different severity.

Clin Neurophysiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology and Clinical Neurophysiology, Auckland District Health Board, Auckland Hospital, Auckland, New Zealand.

Objective: To assess the diagnostic performance of electrophysiology and nerve ultrasound in ulnar neuropathies of varying clinical severity in 135 consecutive patients.

Methods: Clinical severity of ulnar neuropathy was graded on a 4 point scale from very mild (symptoms only) to severe (marked atrophy of intrinsic hand muscles). Sensitivity and localization ability of electrophysiology and nerve ultrasound were assessed for each point of the scale. Read More

View Article
December 2018