448,497 results match your criteria Hand Clinics [Journal]


Tissue Oximetry for Monitoring Free DIEP Flap Viability: Factors to Consider towards Optimizing Postoperative Outcome.

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

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December 2018

In situ soft x-ray absorption spectroscopic study of polycrystalline Fe/MgO interfaces.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Center for Spintronic Materials, Amity University, Sector 125, Noida, INDIA.

Interfacial interactions between a layer of iron and MgO hold the key to various phenomena like, tunnel magnetoresistance, perpendicular magnetic anisotropy, interlayer exchange coupling, observed in the system. Interface structure has been studied<i> in situ </i>during deposition of iron on MgO surface, using soft x-ray absorption spectroscopy (SXAS). Sub-monolayer sensitivity of SXAS, combined with <i>in situ</i> measurements as a function of iron layer thickness, allowed one to study the evolution of interface with film thickness. Read More

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December 2018

Stability of synthetic cathinones in blood and urine.

Forensic Sci Int 2018 Dec 6;295:36-45. Epub 2018 Dec 6.

Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.

Introduction: Although there is an observed decline in the number of new psychoactive substances entering the drug market, this phenomenon is still a significant public health problem. Synthetic cathinones are the second largest group of new substances and currently belong to the most frequently confiscated. Their availability and prevalence cause that they are often abused. Read More

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December 2018
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Evidences of different meteorological patterns governing Be and Pb surface levels in the southern Iberian Peninsula.

J Environ Radioact 2018 Dec 14;198:1-10. Epub 2018 Dec 14.

Department of Integrated Sciences, Area of Applied Physics, University of Huelva, 21071, Huelva, Spain; Research Center on Natural Resources, Health and the Environment (RENSMA), University of Huelva, 21071, Huelva, Spain.

Be, Pb and PM levels in surface air have been simultaneously measured at two sampling sites in the southern Iberian Peninsula for a period of two years. Each site covers one different meteorological area of the Guadalquivir valley, from the mouth (Huelva) to the middle point (Cordoba). The objective of the present study is to analyse the spatial variability of both natural radionuclides, and to identify and characterise the meteorological patterns associated with similar and different surface concentration levels in this complex region. Read More

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December 2018

Current perspectives of Australian therapists on rehabilitation and return to sport after anterior cruciate ligament reconstruction: A survey.

Phys Ther Sport 2018 Dec 10;35:139-145. Epub 2018 Dec 10.

Perth Orthopaedic and Sports Medicine Centre, West Perth, Western Australia, Australia.

Objectives: To investigate views and practices of Australian therapists on rehabilitation and return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR).

Design: Survey-based study.

Setting: Online survey platform. Read More

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December 2018

Sublethal concentrations of chlorpyrifos induce changes in the thermal sensitivity and tolerance of anuran tadpoles in the toad Rhinella arenarum?

Chemosphere 2018 Dec 7;219:671-677. Epub 2018 Dec 7.

Departamento de Ecología Evolutiva, Estación Biológica de Doñana, CSIC, Avda. Américo Vespucio s/n, 41092, Sevilla, Spain. Electronic address:

Amphibians are considered one of the groups most susceptible to chemical contamination, therefore are good bio-indicators of aquatic pollution. Synergistic effects of temperature and pesticides have been found in amphibians determining amplified toxicity effect on survival and malformations with increasing temperatures. We studied the sensitivity of sublethal concentrations of chlorpyrifos in Rhinella arenarum tadpoles over on two fitness related thermal traits: locomotor swimming performance and thermal tolerance limits (CT = critical thermal maximum and CT = critical thermal minimum). Read More

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December 2018
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Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A.

Ecotoxicol Environ Saf 2018 Dec 14;170:495-501. Epub 2018 Dec 14.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Halogenated bisphenol A analogues (X-BPA) have been widely used in industrial production, such as flame retardant. Although BPA exposure was found to result in cytotoxicity, toxicity of X-BPA and molecular mechanism remain under-explored. In this study, we employed human breast cancer cell as a model to investigate the concentration-dependent toxicity and underlying mechanisms of tetrabromo bisphenol A (TBBPA) and tetrachloro bisphenol A (TCBPA). Read More

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December 2018

Aquatic animal viruses mediated immune evasion in their host.

Authors:
Fei Ke Qi-Ya Zhang

Fish Shellfish Immunol 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

Viruses are important and lethal pathogens that hamper aquatic animals. The result of the battle between host and virus would determine the occurrence of diseases. The host will fight against virus infection with various responses such as innate immunity, adaptive immunity, apoptosis, and so on. Read More

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December 2018

Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease.

Neurochem Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA. Electronic address:

Manganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopaminergic cells. Read More

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December 2018

PPARα suppresses Th17 cell differentiation through IL-6/STAT3 /RORγt pathway in experimental autoimmune myocarditis.

Exp Cell Res 2018 Dec 14. Epub 2018 Dec 14.

Medical College of Xiamen University, Xiamen 361102, China. Electronic address:

Family members of peroxisome proliferator-activated receptors (PPARs), such as PPARγ, have been shown to be effective in regulating T helper 17 (Th17) cell differentiation. However, whether PPARα, another important family member of PPARs, contributes to Th17 cell differentiation remains controversial. In the present study, we show that PPARα may be a negative regulator of Th17 cell differentiation. Read More

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December 2018

Electro-orientation of silver nanowires in alternating fields.

Langmuir 2018 Dec 17. Epub 2018 Dec 17.

In this work we analyse the orientation of silver nanowires immersed in aqueous solutions, under the effect of alternating electric fields in a broad frequency range, covering from a few Hz to several MHz. The degree of orientation is experimentally determined by electro-optical techniques, which present the advantage of measuring multiple particles at the same time. In the electro-orientation spectrum, we observe a frequency dispersion in the kHz range, and provide a theoretical explanation for this behaviour: at high frequencies, charge separation in the nanoparticles leads to a large induced dipole, responsible for strong orientation. Read More

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December 2018

A pedicled split extended vertical deep inferior epigastric (s-vDIEP) flap and an adipo-dermal thigh local flap for the reconstruction of the medial thigh compartment after sarcoma resection: A case report.

Microsurgery 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.

Large upper medial thigh defects in prior irradiated tissue require challenging reconstructions. Several techniques have been reported to reconstruct this region and according to the literature, pedicled perforator flaps are the first reconstructive option. The anterolateral thigh flap is considered the gold standard, while surprisingly the pedicle deep inferior epigastric (DIEP) flap in vertical fashion has not been frequently employed, if compared with its muscular counterpart, the pedicle vertical rectus abdomins flap (vRAM). Read More

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December 2018
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Neuroticism related differences in working memory tasks.

PLoS One 2018 17;13(12):e0208248. Epub 2018 Dec 17.

Division of Psychology, Department of Life Sciences, Centre for Cognitive Neuroscience (CCN), Brunel University London, Uxbridge, United Kingdom.

Two influential theories relating to personality traits, i.e. arousal-based theory (ABT) and attentional control theory (ACT), made predictions on how neuroticism may affect task performance. Read More

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December 2018

Genome-wide association mapping of spot blotch resistance in wheat association mapping initiative (WAMI) panel of spring wheat (Triticum aestivum L.).

PLoS One 2018 17;13(12):e0208196. Epub 2018 Dec 17.

International Maize and Wheat Improvement Center (CIMMYT), DPS Marg, New Delhi, India.

Spot blotch (SB) caused by Bipolaris sorokiniana, is one of the most important diseases of wheat in the eastern part of south Asia causing considerable yield loss to the wheat crop. There is an urgent need to identify genetic loci closely associated with resistance to this pathogen for developing resistant cultivars. Hence, genomic regions responsible for SB resistance were searched using a wheat association mapping initiative (WAMI) panel involving 287 spring wheat genotypes of different origin. Read More

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December 2018
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Quantifying Burn Injury-Related Disability and Quality of Life in the Developing World: A Primer for Patient-Centered Resource Allocation.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Department of Plastic Surgery, The University of Virginia, Charlottesville, VA.

Background: Untreated or undertreated burns are commonly encountered by plastic surgeons on medical trips in India and represent a major cause of disability. We sought to utilize validated patient-reported outcomes instruments to identify the patient population with the greatest burn-related disability in order to appropriately allocate plastic surgery resources to those in greatest need.

Methods: The Quick Disability of the Arm, Shoulder, and Hand, RAND 36-Item Short Form Health Survey, and Burn-Specific Health Scale-Revised, Brief, and Adapted questionnaires were administered via an interpreter during a plastic surgery trip to Jharkhand, India, in January 2018. Read More

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December 2018
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Long Term Follow Up of a Vascularized Osteocutaneous Free Flap for Reconstruction in Charcot Neuroarthropathy: A Case Report.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD.

Vascularized osteocutaneous free flaps have seen increasing use in foot and ankle surgery for the repair of bony defects secondary to chronic nonunion, osteomyelitis, and fractures. One example is the Medial Femoral Condyle (MFC) Flap. The utility of the MFC flap for the repair of a bony defect in a diabetic patient, however, has yet to be explored. Read More

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December 2018
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Quick Calculation of Breast Resection Mass Using the Schnur Scale.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

In 1991, Dr Paul Schnur and his colleagues published an article correlating the weight of breast tissue to be removed in a breast reduction operation with the total body surface area (BSA) of the patient. They presented a very cogent argument for selecting three groups of patients: those with medical indications for operation, those who merit review, and those whose operation could be considered cosmetic. The Schnur Sliding Scale is widely used by insurance companies in the western United States in the process of preauthorizing breast reduction operations, and its use may be spreading eastward. Read More

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December 2018
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Functional results of wrist arthrodesis versus arthroplasty with proximal fibula following giant cell tumour excision of the distal radius.

J Hand Surg Eur Vol 2018 Dec 17:1753193418809785. Epub 2018 Dec 17.

Bone and Soft Tissue Tumour Centre, People's Hospital of Beijing University, Beijing, China.

Twenty-one patients underwent excision of a Campanacci grade III giant cell tumour of the distal radius and had reconstruction using a proximal fibula autograft. We compared the functional results of wrist arthrodesis versus arthroplasty. All 21 patients healed in an average of 8 months, and all have remained disease free. Read More

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December 2018

Effects of simultaneous steroid injection after percutaneous trigger finger release: a randomized controlled trial.

J Hand Surg Eur Vol 2018 Dec 17:1753193418813771. Epub 2018 Dec 17.

4 Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

The purpose of this study was to test the hypothesis that an improved outcome can be achieved by employing simultaneous steroid injection after percutaneous A1 pulley release. One hundred and twelve digits were randomized to either percutaneous A1 pulley release alone or release of the A1 pulley with a steroid injection. The visual analogue scale score for pain, modified patient global impression of improvement and modified Quinnell grade were assessed at 3 weeks and 3 months after surgery. Read More

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December 2018

Breast reconstruction with a dermal sling: a systematic review of surgical modifications.

J Plast Surg Hand Surg 2018 Dec 17:1-12. Epub 2018 Dec 17.

a Department of clinical sciences , University of Gothenburg. The Sahlgrenska Academy , Gothenburg , Sweden.

A dermal sling (DS) is used to cover the implant with two layers of tissue when immediate breast reconstruction is performed in women with large and ptotic breasts. It works as an autologous acellular dermal matrix/mesh that can be used to control the implant pocket and inframammary fold, without inferring an extra foreign material and higher costs. There is relatively little published about the DS technique. Read More

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December 2018
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Japanese Encephalitis Virus-induced let-7a/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.

J Neurochem 2018 Dec 17. Epub 2018 Dec 17.

Translational Health Science and Technology Institute, Faridabad, India.

MicroRNAs (miRNAs) released from the activated microglia upon neurotropic virus infection may exacerbate the neuronal damage. Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs overexpressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JEV-infected microglial cells through extracellular vesicles. The let-7a/b were previously reported to modulate inflammation in microglial cells through Toll-like receptor 7 (TLR7) pathways; though their role in accelerating JEV pathogenesis remain unexplored. Read More

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December 2018

Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.

Importance: Measurement of delirium severity has been recognized as highly important for tracking prognosis, monitoring response to treatment, and estimating burden of care for patients both during and after hospitalization. Rather than simply rating delirium as present or absent, the ability to quantify its severity would enable development and monitoring of more effective treatment approaches for the condition.

Objectives: To present a comprehensive review of delirium severity instruments, conduct a methodologic quality rating of the original validation study of the most commonly used instruments, and select a group of top-rated instruments. Read More

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December 2018

Staying on your feet: the effectiveness of posture and handles in counteracting balance perturbation.

Ergonomics 2018 Dec 17:1-27. Epub 2018 Dec 17.

a Laboratory for Neuromechanics and Biorobotics, Department of Automation, Biocybernetics and Robotics , Jožef Stefan Institute , Ljubljana , Slovenia.

Stairways, public transport, and inclined walkways are often considered as sites with higher likelihood of falls due to a sudden loss of balance. Such sites are usually marked with warning signs, equipped with non-slip surfaces and handles or handrails to avert or decrease this likelihood. Especially handles are supposed to provide additional support in cases of a sudden loss of balance. Read More

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December 2018

[So-called "difficult children" urgently needed their own medical association: the history of the introduction of the specialist title of "child and youth psychiatry" in Germany in 1968].

Z Kinder Jugendpsychiatr Psychother 2018 Oct 17:1-10. Epub 2018 Oct 17.

1 Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie, Universitätsklinik Ulm.

So-called "difficult children" urgently needed their own medical association: the history of the introduction of the specialist title of "child and youth psychiatry" in Germany in 1968 Abstract. In post-war Germany, child psychiatry (CP) was not an independent discipline but part of adult psychiatry/neurology. The primary goal of adult psychiatrists of the day was to maintain power in all areas dealing with nervous diseases and their treatment. Read More

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October 2018

Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung.

Expert Opin Ther Targets 2018 Dec 17. Epub 2018 Dec 17.

a Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Introduction: Kelch-like ECH associated protein 1/Nuclear factor erythroid 2-like factor 2 (Keap1-Nrf2) signaling plays a pivotal role in response to oxidative stress in lung cancer. Mutations in KEAP1/NFE2L2 genes always cause persistent Nrf2 activation in lung cancer cells that confers therapeutic resistance and aggressive tumorigenic activity, dictating either poor prognosis or short duration of response to chemotherapy in clinical observations. These findings suggest that modulation of Keap1-Nrf2 signaling presents to be a promising therapeutic target in adenocarcinomas of lung. Read More

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December 2018

A First-Principles Study on the Adsorption of Small Molecules on Arsenene: Comparison of Oxidation Kinetics in Arsenene, Antimonene, Phosphorene and InSe.

Chemphyschem 2018 Dec 17. Epub 2018 Dec 17.

Institute for Metals Superplasticity Problems, Russian Academy of Sciences, RUSSIAN FEDERATION.

Arsenene, a new group V two-dimensional (2D) material beyond phosphorene and antimonene, has recently gained an increasing attention owning to its various interesting properties which can be altered or intentionally functionalized by chemical reactions with various molecules. This work provides a systematic study on the interactions of arsenene with the small molecules, including H2, NH3, O2, H2O, NO, and NO2. It is predicted that O2, H2O, NO, and NO2 are strong acceptors, while NH3 serves as a donor. Read More

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December 2018

Kienböck Disease: Quality, Accuracy, and Readability of Online Information.

Hand (N Y) 2018 Dec 16:1558944718813631. Epub 2018 Dec 16.

1 Columbia University Medical Center, New York, NY, USA.

Background: Patients with limited health literacy require online educational materials to be written below a sixth grade level for optimal understanding. We assessed the quality, accuracy, and readability of online materials for Kienböck disease (KD).

Methods: "Kienbock's Disease" and "Lunate Avacular Necrosis" were entered into 3 search engines. Read More

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December 2018

[Complete triceps tendon rupture; a rare tendon injury].

Ned Tijdschr Geneeskd 2018 Nov 2;162. Epub 2018 Nov 2.

UMC Utrecht, afd. Heelkunde.

Only 1% of all tendon injuries affect the triceps tendon, making triceps ruptures very rare. An acute rupture can therefore easily be missed due to a low degree of suspicion. A palpable gap, inability to flex the elbow against resistance and a positive modified Thompson test are indicative for a complete triceps tendon rupture. Read More

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November 2018
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Increased perfusion in dynamic gadolinium-enhanced MRI correlates with areas of bone repair and of bone necrosis in patients with Kienböck's disease.

J Magn Reson Imaging 2018 Dec 16. Epub 2018 Dec 16.

Department of Hand Surgery, Lund University, Malmö, Sweden.

Background: Osteonecrosis of the lunate, Kienböck's disease, can lead to fragmentation of the lunate, carpal collapse, and severe osteoarthritis. Since the etiology of Kienböck's disease is impaired circulation, a diagnostic method capable of assessing perfusion would be valuable. Recent studies have suggested that dynamic contrast-enhanced (DCE) MR examinations at 3 T can assess perfusion in healthy carpal bones. Read More

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December 2018

"Slime" dermatitis, a fad-associated chronic hand dermatitis.

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Division of Dermatology, Children's National Health Center, Washington, District of Columbia.

"Slime" is the colloquial name for a non-Newtonian viscoelastic putty-like substance that is currently a popular plaything among pre-teens and adolescents. Several ingredients in homemade slime recipes may cause irritant or allergic contact dermatitis. We report two children who developed slime-associated chronic hand dermatitis, more prominently on their dominant hand. Read More

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December 2018

Waterlogging-induced adventitious root formation in cucumber is regulated by ethylene and auxin through reactive oxygen species signaling.

Plant Cell Environ 2018 Dec 16. Epub 2018 Dec 16.

Department of Horticulture, School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, China.

Development of adventitious roots (ARs) at the base of the shoot is an important adaptation of plants to waterlogging stress; however, its physiological mechanisms remain unclear. Here, we investigated the regulation of AR formation under waterlogged conditions by hormones and reactive oxygen species (ROS) in Cucumis sativus L., an agriculturally and economically important crop in China. Read More

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December 2018

The burden of hospitalized sports-related injuries in children: an Australian population-based study, 2005-2013.

Inj Epidemiol 2018 Dec 17;5(1):45. Epub 2018 Dec 17.

Child Population and Translational Health Research, The Children's Hospital at Westmead Clinical School, Level 2 The Hub, Charles Perkins Centre D17, The University of Sydney, Westmead, NSW, 2006, Australia.

Background: There is concern about recent increase and severity of sports-related injuries in children. Despite the benefits of sports participation, injuries may carry long-term health consequences. We aimed to evaluate the prevalence, characteristics and types of hospitalized sports-related injuries in children. Read More

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December 2018
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The newborn conjunctival flora at the post delivery 24 hours.

J Curr Ophthalmol 2018 Dec 10;30(4):348-352. Epub 2018 Apr 10.

Department of Microbiology, Kayseri Training and Education Hospital, Kayseri, Turkey.

Purpose: The aim of this study was to investigate the aerobic conjunctival flora of neonates and the effects of delivery type on conjunctival flora development in neonates who were born with normal spontaneous vaginal delivery (SVD) or elective caesarean section (C/S) and who were not given prophylactic antibiotic eye drops after birth.

Methods: This cross-sectional study included 95 healthy newborns. One day after the delivery, conjunctival samples were taken from newborns who were born with normal SVD or elective C/S, and not given prophylactic antibiotic eye drops after birth. Read More

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December 2018

Latent, Immunosuppressive Nature of Poly(lactic--glycolic acid) Microparticles.

ACS Biomater Sci Eng 2018 Mar 3;4(3):900-918. Epub 2018 Feb 3.

Department of Biomedical Engineering, University of California Davis, 1 Shields Avenue, Davis, California 95616, United States.

Use of biomaterials to spatiotemporally control the activation of immune cells is at the forefront of biomedical engineering research. As more biomaterial strategies are employed for immunomodulation, understanding the immunogenicity of biodegradable materials and their byproducts is paramount in tailoring systems for immune activation or suppression. Poly(D,L-lactic--glycolic acid) (PLGA), one of the most commonly studied polymers in tissue engineering and drug delivery, has been previously described on one hand as an immune adjuvant, and on the other as a nonactivating material. Read More

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March 2018
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Phantom-Mobility-Based Prosthesis Control in Transhumeral Amputees Without Surgical Reinnervation: A Preliminary Study.

Front Bioeng Biotechnol 2018 29;6:164. Epub 2018 Nov 29.

CNRS, ISM, Aix Marseille Université, Marseille, France.

Transhumeral amputees face substantial difficulties in efficiently controlling their prosthetic limb, leading to a high rate of rejection of these devices. Actual myoelectric control approaches make their use slow, sequential and unnatural, especially for these patients with a high level of amputation who need a prosthesis with numerous active degrees of freedom (powered elbow, wrist, and hand). While surgical muscle-reinnervation is becoming a generic solution for amputees to increase their control capabilities over a prosthesis, research is still being conducted on the possibility of using the surface myoelectric patterns specifically associated to voluntary Phantom Limb Mobilization (PLM), appearing naturally in most upper-limb amputees without requiring specific surgery. Read More

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November 2018

Cognitive Errors and Risks Associated with Provider Handoffs.

Cureus 2018 Oct 12;10(10):e3442. Epub 2018 Oct 12.

Emergency Medicine, Florida Hospital, Orlando, USA.

The emergency department is a challenging environment to practice medicine, primarily due to the pace and logistics of practicing emergency medicine. Cognitive errors and provider handoffs can lead to poor patient outcomes. By acknowledging and addressing cognitive errors, including premature closure, anchoring, and diagnosis momentum, we can potentially improve patient care. Read More

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October 2018
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Prolactin-induced protein (PIP)-characterization and role in breast cancer progression.

Am J Cancer Res 2018 1;8(11):2150-2164. Epub 2018 Nov 1.

Department of Human Morphology, Division of Histology and Embryology, Wroclaw Medical University Wroclaw, Poland.

Prolactin-induced protein (PIP) is a small secreted glycoprotein carrying several N-linked carbohydrate chains. The expression of PIP is generally restricted to cells with apocrine properties. It was found in apocrine glands of the axilla, vulva, eyelid, ear canal, and seminal vesicle. Read More

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November 2018

Alarming levels of antimicrobial resistance among sepsis patients admitted to ICU in a tertiary care hospital in India - a case control retrospective study.

Antimicrob Resist Infect Control 2018 7;7:150. Epub 2018 Dec 7.

1Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi, 110007 India.

Background: Hospital acquired infections (HAI) are principal threats to the patients of intensive care units. An increase in the antimicrobial resistance (AMR) observed in gram negative bacteria is a great challenge to deal with. HAI and AMR lead to prolonged hospitalization and additional doses of anti-microbial treatment affecting patient's fitness and finances. Read More

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December 2018

Single-Bone Forearm Salvage Procedure for a Child with Acquired Radial Clubhand in a Resource Limited Centre: A Case Report.

Malays Orthop J 2018 Nov;12(3):43-46

Department of Orthopaedics, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia.

Acquired radial clubhand deformity can be a consequence of large bone gap left by premature extensive radius osteomyelitis sequestrectomy. Single-bone forearm reconstruction is a salvage procedure when other motion-preserving techniques are not feasible. Here we present a child who developed radial clubhand deformity after an untimely sequestrectomy of radius diaphysis. Read More

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November 2018

Functional Outcome after Treatment of Aggressive Tumours in the Distal Radius: Comparison between Reconstruction using Proximal Fibular Graft and Wrist Fusion.

Malays Orthop J 2018 Nov;12(3):19-23

Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Restoration of a functional hand is the ultimate goal following a distal radius tumour resection. The early outcomes of mobile wrist reconstruction are satisfactory; however, long-term results are unpredictable due to late wrist instability and degenerative arthritis. Our aim is to compare mobile wrist reconstruction with wrist fusion (pan-carpal fusion) in our cohort of patients. Read More

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November 2018

Just flip it!-CRT implantation in a patient with dextrocardia and situs inversus totalis.

J Arrhythm 2018 Dec 6;34(6):656-658. Epub 2018 Oct 6.

Heart Rhythm Services - St-Paul's Hospital University of British Columbia Vancouver BC Canada.

Implantation of a cardiac resynchronization therapy (CRT) device in patients with congenital heart disease may be challenging because of the particular underlying anatomy. We present the case of a right-sided transvenous implantation of a dual-chamber CRT-D device in a patient with situs inversus totalis and mirror image dextrocardia. To facilitate our anatomic orientation and to overcome unusual hand-eye coordination problems, we decided to flip the fluoroscopic image projection by 180° (right-left), creating the optical impression of a "normalized" heart position (levocardia). Read More

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December 2018

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.

Theranostics 2018 10;8(20):5713-5730. Epub 2018 Nov 10.

Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.

Skin cells are vulnerable to oxidative stress-induced senescence, which may lead to abnormal aging or aging-related disorders. Therefore, strategies that can ameliorate oxidative stress-induced senescence are expected to protect skin from damage, holding the promise of treating skin diseases in the clinic. This study aims to investigate whether caffeine, a well-known purine alkaloid, is able to prevent skin from oxidative stress-induced senescence, and to explore the underlying molecular mechanisms. Read More

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November 2018

Absolute Quantification of in Grapevine Leaf and Petiole Tissues by Proteomics.

Front Plant Sci 2018 29;9:1735. Epub 2018 Nov 29.

Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Grapevine red blotch is a recently identified viral disease that was first recognized in the Napa Valley of California. Infected plants showed foliar symptoms similar to leafroll, another grapevine viral disease, on vines testing negative for known grapevine leafroll-associated virus. Later, the (GRBV) was independently discovered in the US states of California and New York and was demonstrated to be the causal agent of red blotch disease. Read More

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November 2018

Cheating the Hunger Games; Mechanisms Controlling Clonal Diversity of CD8 Effector and Memory Populations.

Front Immunol 2018 29;9:2831. Epub 2018 Nov 29.

Department of Histology & Embryology University of Rijeka, Rijeka, Croatia.

Effector and memory CD8 T cells have an intrinsic difference in the way they must approach antigen; effector cells need to address the pathogen at hand and therefore favor outgrowth of only high-affinity clones. In contrast, the memory pool benefits from greater clonal diversity to recognize and eliminate pathogens with mutations in their immunogenic epitopes. Effector and memory fates are ultimately the result of the same three signals that control T cell activation; T cell receptor (TCR) engagement together with co-stimulation and cytokines. Read More

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November 2018
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A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the SSL7 Protein.

Front Immunol 2018 29;9:2822. Epub 2018 Nov 29.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases. As general inhibition of the complement system may jeopardize patient health due to increased susceptibility to infections, the development of pathway-specific complement therapeutics has been a long-lasting goal over the last decades. Read More

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November 2018

The Influence of Pentraxin 3 on the Ovarian Function and Its Impact on Fertility.

Front Immunol 2018 29;9:2808. Epub 2018 Nov 29.

Histology and Embryology Section, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy.

Follicular development is a highly coordinated process that in humans takes more than 6 months. Pituitary gonadotropins and a variety of locally produced growth factors and cytokines are involved in determining a precise sequence of changes in cell metabolism, proliferation, vascularization, and matrix remodeling in order to obtain a follicle with full ovulatory and steroidogenic capability. A low-grade inflammation can alter such processes leading to premature arrest of follicular growth and female reproductive failure. Read More

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November 2018
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Does Resting Motor Threshold Predict Motor Hand Recovery After Stroke?

Front Neurol 2018 29;9:1020. Epub 2018 Nov 29.

Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Resting Motor threshold (rMT) is one of the measurement obtained by Transcranial Magnetic Stimulation (TMS) that reflects corticospinal excitability. As a functional marker of the corticospinal pathway, the question arises whether rMT is a suitable biomarker for predicting post-stroke upper limb function. To that aim, we conducted a systematic review of relevant studies that investigated the clinical significance of rMT in stroke survivors by using correlations between upper limb motor scores and rMT. Read More

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November 2018

Reduction in the Level of Plasma Mitochondrial DNA in Human Diving, Followed by an Increase in the Event of an Accident.

Front Physiol 2018 29;9:1695. Epub 2018 Nov 29.

Institut de Recherche Biomédicale des Armées, Equipe Résidante de Recherche Subaquatique Opérationnelle, Département Environnement Opérationnel, Unité Environnements Extrêmes, Toulon, France.

Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity or trauma. In the context of decompression sickness (DCS), the course of which is sometimes erratic, we hypothesize that mtDNA plays a not insignificant role particularly in neurological type accidents. This study is based on the comparison of circulating mtDNA levels in humans presenting with various types of diving accidents, and punctured upon their admission at the hyperbaric facility. Read More

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November 2018

A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features.

Front Physiol 2018 30;9:1693. Epub 2018 Nov 30.

Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. Read More

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November 2018