1,773 results match your criteria Hamartoma Lung


Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
March 2018
3 Reads

Giant hamartoma of lung presented with massive hemoptysis: A rare case report and review of the literature.

Rare Tumors 2019 10;11:2036361318823926. Epub 2019 Jan 10.

Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

Hamartoma of lung is a common tumor, majority of which are small and incidentally discovered during plain chest radiography. Our case is a 30-year-old gentleman with an extremely uncommon presentation of a common tumor, that is, a giant hamartoma of lung presenting as massive hemoptysis and intractable cough. To the best of our knowledge, such occurrence of giant pulmonary hamartoma is very uncommon and its presentation with massive hemoptysis is even more uncommon. Read More

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http://dx.doi.org/10.1177/2036361318823926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348499PMC
January 2019

[Clinical analysis of 5 cases of endobronchial hamartoma].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Jan;42(1):15-19

Department of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

To analyze the clinical manifestations of patients with endobronchial hamartoma(EH),and therefore to improve understanding of the disease. Data were retrospectively reviewed to describe the clinical characteristics, diagnosis procedures and prognosis of EH, including 5 patients in Beijing Anzhen Hospital, Capital Medical University from Jun 2007 to Feb 2018 and another 159 patients from Chinese and English literatures published after Jan 2000. The five patients, 4 males and 1 female, aged from 46 to 69 years[mean (56±7) years], were diagnosed with EH in our hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.01.006DOI Listing
January 2019

Extralobar Sequestration Complicated by a Cystic Hamartoma in an Adult.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department Pulmonary and Critical Care Medicine, Lankenau Medical Center. 100 Lancaster Avenue, Wynnewood, PA 19096. Electronic address:

A 49 year old female presented after a respiratory infection with a abnormal chest X-ray demonstrating a cystic calcified mass at the base of the right lung. Chest CT angiogram demonstrated the blood supply arose from the abdominal aorta. This Extralobar sequestration was surgically resected via Video assisted thoracoscopy without complication. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.10.072DOI Listing
December 2018

Bronchial artery embolization for treatment of hemoptysis caused by peripheral pulmonary hamartoma.

Lung India 2018 Nov-Dec;35(6):530-531

Department of Intervention and Diagnostic Radiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

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http://dx.doi.org/10.4103/lungindia.lungindia_236_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219123PMC
November 2018
1 Read

Concomitant a giant pulmonary bulla on the left lower lobe and hamartoma successfully treated by video-assisted thoracoscopic pulmonary wedge resection.

AME Case Rep 2017 26;1. Epub 2017 Sep 26.

Department of Pathology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

A 48-year-old woman was admitted for pectoralgia and dyspnea. Tomography revealed a giant lung bulla with a mass arose from the bulla wall in the left lower lobes, and left lower lobes pulmonary wedge resection was performed through video-assisted thoracic surgery (VATS). The giant bulla was formed by fibrous connective tissue covered by monolayer pavement epithelium. Read More

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http://dx.doi.org/10.21037/acr.2017.09.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155569PMC
September 2017
1 Read

Conversion to thoracotomy during VATS segmentectomy for treatment of symptomatic endobronchial hamartoma.

Int J Surg Case Rep 2018 12;51:272-274. Epub 2018 Sep 12.

Division of Thoracic Surgery, Monaldi Hospital, Leonardo Bianchi Street, 80131, Naples, Italy.

Introduction: Most hamartomas are located peripherally in the lung parenchyma and are rarely identified as an endobronchial lesion. Clinically patients with an endobronchial hamartoma are often symptomatic and may present with various symptoms including: fever, wheezing, hemoptysis and obstructive pneumonia.

Case Presentation: A 68-year-old man presented with complaints of fever and cough for 1 month. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139489PMC
September 2018
1 Read

Pulmonary hamartoma mimicking a mediastinal cyst-like lesion in a heavy smoker.

Respir Med Case Rep 2018 14;25:133-136. Epub 2018 Aug 14.

Division of Pulmonology, Spedali Civili of Brescia, Brescia, Italy.

Pulmonary hamartoma (PH) is the most common benign tumor of the lung, typically presenting as a peripheral solitary nodule with round shape and smooth margins. The main computed tomography (CT) features that allow a confident diagnosis of PH are intranodular fat and popcorn-like calcifications. However, the presence of these features within PHs is variable. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098234PMC
August 2018
4 Reads

Tuberous sclerosis complex: review based on new diagnostic criteria.

An Bras Dermatol 2018 Jun;93(3):323-331

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Tuberous sclerosis complex is a multisystemic, autosomal dominant genetic disorder with complete penetrance, that can evolve with hamartomas in multiple organs, such as skin, central nervous system, kidney and lung. Due to the wide phenotypic variability, the disease is often not recognized. Tuberous sclerosis complex affects one in 10,000 newborns and most patients are diagnosed during the first 15 months of life. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001077PMC
June 2018
3 Reads

Sampling Utility of the Convex Probe Endobronchial Ultrasound Visible Intrapulmonary Lesion.

J Bronchology Interv Pulmonol 2018 Oct;25(4):290-299

Pathology and Laboratory Institute, Cleveland Clinic, Cleveland, OH.

Background: The value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the mediastinal staging of lung cancer has been well established. However, data regarding its utility in the diagnosis of intrapulmonary lesions has been sparse. This study assesses the sampling utility of convex probe EBUS-visible intrapulmonary lesions not visualized by the white-light bronchoscopy. Read More

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http://Insights.ovid.com/crossref?an=01436970-201810000-0000
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http://dx.doi.org/10.1097/LBR.0000000000000509DOI Listing
October 2018
6 Reads

An unusual case of pulmonary hamartoma with predominant bronchial mucous glands in the peripheral lung.

Pathol Int 2018 Jul 16;68(7):431-435. Epub 2018 May 16.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Pulmonary hamartoma (PH) is the most common benign lung tumor, comprising various amounts of mescenchymal components with entrapped epithelial components. We describe an unusual case of PH in the left lower lung lobe of a 60-year-old female. The tumor was 9 × 9 mm in size, light brown, weakly glistening, and microscopically found to be composed of well-developed epithelial and mesenchymal components without atypia. Read More

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http://dx.doi.org/10.1111/pin.12682DOI Listing
July 2018
2 Reads

Placental transmogrification of the lung presenting as a peripheral solitary nodule in a male with the history of trauma: A case report.

Medicine (Baltimore) 2018 May;97(18):e0661

Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Rationale: Placental transmogrification of the lung is a very rare lesion which was characterized by the presence of papillae resembling placental villi. Its pathogenesis still remains unclear. Some authors think that this lesion is congenital and related to hamartoma, and others advocate it is secondary change after emphysema. Read More

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http://dx.doi.org/10.1097/MD.0000000000010661DOI Listing
May 2018
3 Reads

Diagnostic value of F-FDG-PET/CT in benign lung diseases.

Kardiochir Torakochirurgia Pol 2018 Mar 28;15(1):1-4. Epub 2018 Mar 28.

Thoracic Surgery Department, Faculty of Medicine, Ege University, Izmir, Turkey.

Introduction: There are many diseases which, despite not being malignant, show high metabolic activity and cause false-positive results.

Aim: To evaluate the results of positron emission tomography (PET) in patients who underwent resection after preliminary diagnosis of malignancy based on fluorodeoxyglucose (FDG) uptake value, in whom the lesions were later classified as pathologically benign.

Material And Methods: The analysis included the records of 106 (12. Read More

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http://dx.doi.org/10.5114/kitp.2018.74667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907609PMC
March 2018
2 Reads

Pulmonary inflammatory myofibroblastic tumor: a case report.

Asian Cardiovasc Thorac Ann 2018 May 12;26(4):317-319. Epub 2018 Apr 12.

Department of Thoracic Surgery, 13622 JR Tokyo General Hospital , Tokyo, Japan.

Pulmonary inflammatory myofibroblastic tumor is a rare disease. Computed tomography in a 54-year-old woman showed a mass compressing the segmental bronchus of the left lung. Bronchoscopy indicated a mesenchymal tumor, hamartoma, or inflammatory myofibroblastic tumor. Read More

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http://dx.doi.org/10.1177/0218492318770845DOI Listing
May 2018
1 Read

Giant Pulmonary Hamartoma with Dominant CD34- Positive Smooth Muscle Cell Component.

Tokai J Exp Clin Med 2018 Apr 20;43(1):1-4. Epub 2018 Apr 20.

Department of Pathology, Tokai University School of Medicine,143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Pulmonary hamartoma (PH) is usually a solid mass of less than 4 cm in size that contains cartilage omponents. A 44-year-old Japanese woman received surgical resection of a well-demarcated cystic tumor in the right lung. Resected tissue contained a 13 × 10 × 8 cm-sized solid mass with a prominent unilocular cyst (8 × 6. Read More

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April 2018
1 Read

Uniportal Video-Assisted Thoracic Surgery for Pulmonary Hamartoma: Case Report.

Acta Clin Croat 2017 Dec;56(4):808-811

Jordanovac University Department of Thoracic Surgery, Zagreb University Hospital Center, Zagreb, Croatia.

Pulmonary hamartoma is the most common benign tumor of the lung. It accounts for 77% of all benign lung tumors but less than 1% of all lung tumors. Malignant alteration is -extremely rare. Read More

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http://dx.doi.org/10.20471/acc.2017.56.04.32DOI Listing
December 2017
1 Read

Linear probe 19-gauge endobronchial ultrasound diagnosis of a benign chondroid hamartoma.

Monaldi Arch Chest Dis 2018 02 7;88(1):890. Epub 2018 Feb 7.

North Bristol Lung Centre, Southmead Hospita.

We report a case of a 68-year-old gentleman, found to have a right hilar soft tissue mass whilst undergoing CT staging for prostate cancer. MRI imaging showed a heterogenous, enhancing solid mass without evidence of fat content. A linear probe endobronchial ultrasound-guided transbronchial needle aspiration was performed using a 19G needle. Read More

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http://dx.doi.org/10.4081/monaldi.2018.890DOI Listing
February 2018
17 Reads

Surgical management of endobronchial hamartoma.

Lung India 2018 Mar-Apr;35(2):179-181

Centre for Chest Surgery, Sir Ganga Ram Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/lungindia.lungindia_209_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846275PMC
March 2018
6 Reads

[Lung Cancer Associated with Hamartoma;Report of a Case].

Kyobu Geka 2018 Feb;71(2):142-145

Division of Chest Surgery, Department of Surgery, Showa University School of Medicine, Tokyo, Japan.

A 65-year-old male was admitted to our hospital for evaluation of an abnormal shadow in the left lung field of chest roentgenogram. A chest computed tomography scan revealed an ill-defined nodule in the superior lingular segment of left lung and a calcified nodule in the left pulmonary apex region. A diagnosis of lung adenocarcinoma in the left lingular was made by transbronchial cytology and the left upper lobectomy with lymph node dissection was performed. Read More

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February 2018
4 Reads

Whole-exome sequencing of chondroid hamartoma of lung identified no driver mutations.

Pathol Res Pract 2018 03 2;214(3):459-462. Epub 2018 Jan 2.

Department of Pathology, The Catholic University of Korea, Seoul, Republic of Korea; Department of Cancer Evolution Research Center, The Catholic University of Korea, Seoul, Republic of Korea; Department of Precision Medicine Research Center, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2017.12.013DOI Listing
March 2018
4 Reads

Tuberous sclerosis complex.

Handb Clin Neurol 2018 ;148:813-822

Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address:

Tuberous sclerosis complex (TSC) is an autosomal-dominant or sporadic multisystem disorder that results from mutations in either TSC1 or TSC2. The primary organs affected include the brain, skin, lung, kidney, and heart, all with variable frequency, penetrance, and severity. There are over 2000 known allelic variants for TSC, including nonsense and misssense mutation, and all pathogenic mutations are inactivating, leading to loss-of-function effects on the encoded proteins, TSC1 and TSC2. Read More

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http://dx.doi.org/10.1016/B978-0-444-64076-5.00052-1DOI Listing
August 2018
15 Reads

Reply to "Renal Lesions in Lymphangioleiomyomatosis and Tuberous Sclerosis Complex Are Rarely Biologically Aggressive".

AJR Am J Roentgenol 2018 03;210(3):W132

4 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.2214/AJR.17.19092DOI Listing
March 2018
2 Reads

Renal Lesions in Lymphangioleiomyomatosis and Tuberous Sclerosis Complex Are Rarely Biologically Aggressive.

AJR Am J Roentgenol 2018 03;210(3):W131

1 Cincinnati Children's Hospital Medical Center, Cincinnati, OH

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http://dx.doi.org/10.2214/AJR.17.18996DOI Listing
March 2018
5 Reads

Organizing Pneumonia as a Histopathological Term.

Turk Thorac J 2017 Jul 1;18(3):82-87. Epub 2017 Jul 1.

Clinif of Chest Diseases, Süreyyapaşa Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: Organizing pneumonia (OP) is an interstitial lung disease characterized by granulation tissue buds in alveoli and alveolar ductus, possibly accompanied by bronchiolar involvement. Histopathologically, OP may signify a primary disease and be observed as a contiguous disease or as a minor component of other diseases. In this study, the clinical significance of histopathological OP lesions and clinical and radiological features of patients with primary OP were examined. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2017.16047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783087PMC
July 2017
2 Reads

Clinical Course of Histologically Proven Multifocal Micronodular Pneumocyte Hyperplasia in Tuberous Sclerosis Complex: A Case Series and Comparison with Lymphangiomyomatosis.

Respiration 2018;95(5):310-316. Epub 2018 Jan 24.

First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Background: Multifocal micronodular pneumocyte hyperplasia (MMPH) is a rare pulmonary manifestation of tuberous sclerosis complex (TSC). Because of its rarity, no previous study has described the detailed clinical course of this disease.

Objectives: This study aimed to clarify the longitudinal clinical characteristics of subjects with MMPH. Read More

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http://dx.doi.org/10.1159/000486101DOI Listing
October 2018
4 Reads

and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Clin Cancer Res 2018 May 17;24(10):2251-2261. Epub 2018 Jan 17.

Department of Pathology, Center for Cancer and Immunology Research, Children's National Medical Center, Washington D.C.

Pathogenic germline variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma, and brain tumors including pineoblastoma and pituitary blastoma. In May 2016, the International PPB Registry convened the inaugural International Symposium to develop consensus testing and surveillance and treatment recommendations. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260592PMC
May 2018
31 Reads
3 Citations
8.722 Impact Factor

Fibrous cephalic plaques in tuberous sclerosis complex.

J Am Acad Dermatol 2018 04 16;78(4):717-724. Epub 2017 Dec 16.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Electronic address:

Background: Fibrous cephalic plaques (FCPs) stereotypically develop on the forehead of patients with tuberous sclerosis complex (TSC). They constitute a major feature for TSC diagnosis and may present before other TSC-related cutaneous hamartomas.

Objective: To describe the clinical characteristics of FCPs in TSC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622173285
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http://dx.doi.org/10.1016/j.jaad.2017.12.027DOI Listing
April 2018
16 Reads
4.450 Impact Factor

Endobronchial hamartoma mimicking malignant lung tumor contralateral endobronchial metastasis: A case report.

Medicine (Baltimore) 2017 Dec;96(49):e9085

aDepartment of Respiratory and Critical Care Medicine, Jiangxi Provincial People's HospitalbDepartment of Cardiology, the Second Affiliated Hospital of Nanchang UniversitycDepartment of Pathology, Jiangxi Provincial People's Hospital, Nanchang, China.

Rationale: Endobronchial hamartoma, the most common benign lung tumor, is located in the bronchus, and it easily mimics lung cancer or bronchial metastasis. Endobronchial hamartoma can cause coughing, hemoptysis, and pulmonary infection; thus, it should be treated right away by surgery or fiberoptic bronchoscopy.

Patient Concerns: We report a rare case of endobronchial hamartoma in which the clinical symptoms and imaging overlapped strongly with malignant lung tumor contralateral endobronchial metastasis. Read More

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http://dx.doi.org/10.1097/MD.0000000000009085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728943PMC
December 2017
6 Reads

Successful use of snare electrocautery via flexible fiberoptic bronchoscopy for removal of an endobronchial hamartoma causing chronic lung atelectasis and mimicking malignancy.

Ther Adv Respir Dis 2017 12;11(12):435-438

Respiratory Department, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.

We present a rare case of giant endobronchial hamartoma coexisting with lung atelectasis for more than 3 years. The small specimen initially biopsied via bronchoscope did not reveal tissue features, but some features were suspicious for squamous cell carcinoma. The lesion was removed completely using snare electrocautery combined with argon plasma coagulation via flexible fiberoptic bronchoscopy. Read More

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http://dx.doi.org/10.1177/1753465817736745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933581PMC
December 2017
25 Reads

Notch transactivates Rheb to maintain the multipotency of TSC-null cells.

Nat Commun 2017 11 29;8(1):1848. Epub 2017 Nov 29.

Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, 1718 Pine Street, Abilene, TX, 79601, USA.

Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC) manifestations; however, the genesis of these abnormalities remains unclear. Here we report on mechanisms controlling the multi-lineage, early neuronal progenitor and neural stem-like cell characteristics of lymphangioleiomyomatosis (LAM) and angiomyolipoma cells. These mechanisms include the activation of a previously unreported Rheb-Notch-Rheb regulatory loop, in which the cyclic binding of Notch1 to the Notch-responsive elements (NREs) on the Rheb promoter is a key event. Read More

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http://dx.doi.org/10.1038/s41467-017-01845-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705704PMC
November 2017
13 Reads

Cystic Lung Disease in Genetic Syndromes with Deficient Tumor Suppressor Gene Function.

Respiration 2017 23;94(6):467-485. Epub 2017 Nov 23.

Cystic lung diseases constitute a distinct group of rare lung disorders, among which two result from monogenic defects affecting tumor suppressor genes: lymphangioleiomyomatosis, either sporadic or associated with tuberous sclerosis complex, and Birt-Hogg-Dubé syndrome. These disorders have similarities in their clinical expression, including occurrence in young adults, multiple pulmonary cysts, recurrent pneumothorax, skin hamartomas, and renal tumors. However, they markedly differ in their gender distribution, pathogenesis, disease course, and prognosis. Read More

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http://dx.doi.org/10.1159/000485106DOI Listing
August 2018
3 Reads

A three-microRNA signature for lung squamous cell carcinoma diagnosis in Chinese male patients.

Oncotarget 2017 Oct 28;8(49):86897-86907. Epub 2017 Jul 28.

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.

Various studies have demonstrated the diagnostic value of microRNA (miRNA) for lung cancer, but miRNA signatures varied between different subtypes. Whether serum miRNAs could be used as biomarkers in lung squamous cell carcinoma (SCC) remains unknown. Using quantitative real-time polymerase chain reaction (qRT-PCR) based Exiqon panel, 38 differentially expressed miRNAs were identified from 3 male lung SCC pool samples and 1 normal control (NC) pool in the initial screening phase. Read More

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http://dx.doi.org/10.18632/oncotarget.19666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689734PMC
October 2017
9 Reads

A Tuberous Sclerosis Family with (c.1030-1G>A) Mutation Found through a Female Presenting as Multiple Ground Glass Nodules in Chest Computed Tomography Incidentally.

Chin Med J (Engl) 2017 Oct;130(20):2510-2512

Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.

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http://dx.doi.org/10.4103/0366-6999.216418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684629PMC
October 2017
11 Reads

Pulmonary placental transmogrification associated with adenocarcinoma of the lung: a case report with a comprehensive review of the literature.

Autops Case Rep 2017 Jul-Sep;7(3):44-49. Epub 2017 Sep 30.

St. John Hospital and Medical Center, Department of Pathology. Detroit, MI, USA.

Pulmonary placental transmogrification (PT) is a rare entity with less than 40 cases reported in the literature. Most reported cases are associated with either bullous emphysema or with pulmonary fibrochondromatous hamartomas. We present only the second case of PT associated with adenocarcinoma of the lung. Read More

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http://dx.doi.org/10.4322/acr.2017.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634434PMC
September 2017
19 Reads

Diagnostic value of using multiplanar reformation images: Case report for rare endotracheal hamartomas.

Medicine (Baltimore) 2017 Oct;96(40):e8231

aDepartment of Radiology, Panyu Central Hospital of Guangzhou, Guangzhou, P.R. China bDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China cDepartment of Radiology, Keck Medical Center of USC, Los Angeles, CA.

Rationale: Pulmonary hamartomas are the most common benign tumor of the lung. Two types of pathologically similar hamartomas exist based on their location. These tumors have a low incidence, are rarely reported and frequently misdiagnosed because of lack of familiarity and/or understanding concerning their imaging features. Read More

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http://dx.doi.org/10.1097/MD.0000000000008231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738014PMC
October 2017
21 Reads

Pulmonary myelolipoma containing osseous tissue: An unexpected finding at autopsy.

Respir Med Case Rep 2017 14;22:254-256. Epub 2017 Sep 14.

Institute of Pathology, University of Zagreb, Šalata 10, Zagreb, Croatia.

Pulmonary myelolipoma is a very rare benign tumor composed of mature adipose tissue and hematopoietic elements such as erythroid, myeloid and megakaryocytic. It usually represents accidental finding during autopsy or chest imaging, since most cases are asymptomatic. Larger masses can lead to hemorrhage, chest pain and chest organ compression. Read More

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http://dx.doi.org/10.1016/j.rmcr.2017.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612809PMC
September 2017
11 Reads

A hamartoma presenting as an intramural upper oesophageal tumour.

J Thorac Dis 2017 Aug;9(8):E698-E701

Department of Otolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Oesophageal hamartomas are extremely rare conditions especially in upper oesophagus. We report on a 20-year-old woman who presented with dysphagia and was diagnosed with a retrosternal 4.9 cm × 9. Read More

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http://dx.doi.org/10.21037/jtd.2017.07.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594130PMC
August 2017
3 Reads

Oesophageal replacement with stomach: A personal series and review of published experience.

J Paediatr Child Health 2017 Dec 11;53(12):1159-1166. Epub 2017 Aug 11.

Department of Paediatric Surgery, The Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.

Aim: To describe the outcomes of oesophageal replacement using stomach in children.

Methods: All children undergoing oesophageal replacement in a regional centre were prospectively recorded in a customised database and subjected to continual follow up. Complications within 30 days were classified as early, and all other complications were classified as late. Read More

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http://dx.doi.org/10.1111/jpc.13653DOI Listing
December 2017
5 Reads

Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study.

PLoS One 2017 9;12(8):e0180939. Epub 2017 Aug 9.

Department of Nephrology, Charité Universitätsmedizin, Berlin, Germany.

Objectives: We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

Methods: Following favorable results from the double-blind core phase of EXIST-2 (NCT00790400), patients were allowed to receive open-label everolimus (extension phase). Patients initially randomly assigned to everolimus continued on the same dose; those who were receiving placebo crossed over to everolimus 10 mg/day. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549893PMC
October 2017
37 Reads

Endotracheal hamartoma case report: Two contrasting clinical presentations of a rare entity.

Int J Surg Case Rep 2017 20;38:98-101. Epub 2017 Jul 20.

Division of Thoracic Surgery, Department of Surgery, Boston University School of Medicine, 72 East Concord St, Boston, MA, 02118, United States. Electronic address:

Introduction: The majority of tracheal tumors in adults are malignant. The finding of a benign tumor in the trachea is uncommon and endotracheal hamartomas are rare.

Presentation Of Case: We report two cases presenting within six months at our institution. Read More

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http://dx.doi.org/10.1016/j.ijscr.2017.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537398PMC
July 2017
12 Reads

Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?

BMC Pulm Med 2017 Jul 28;17(1):107. Epub 2017 Jul 28.

Respiratory Unit, Ospedale San Paolo, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.

Background: Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases.

Case Presentation: A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/autoimmune hepatitis overlap syndrome. Read More

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http://dx.doi.org/10.1186/s12890-017-0447-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534042PMC
July 2017
27 Reads

[Extralobar Sequestration Difficult to Establish Preoperative Diagnosis;Report of a Case].

Kyobu Geka 2017 Jul;70(7):557-559

Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.

Pulmonary sequestration is a rare congenital pulmonary anomaly. Here we report a case of extralobar sequestration with calcification. A 34-year-old man was admitted to our department because of a tumor shadow on the chest radiological examination. Read More

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July 2017
5 Reads

[Pulmonary lymphangioleimyomatosis : review and case report].

Rev Med Suisse 2016 Aug;12(527):1390-1393

Service de pneumologie, HUG, 1211 Genève 14.

Lymphangioleiomyomatosis (LAM) is a rare progressive lung disease, occurring in women of childbearing age, that can occur sporadically (S-LAM) or can be associated with tuberous sclerosis complex (TSC-LAM), an inherited neurocutaneous disorder. This article is illustrated by a case report. We then review clinical manifestations, diagnostic tools, and treatment of this disease. Read More

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August 2016
3 Reads

False-Positive Uptake of Radioiodine in Renal Hamartoma in a Patient With Differentiated Thyroid Cancer.

Clin Nucl Med 2017 Sep;42(9):709-710

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.

A 46-year-old woman with a history of papillary thyroid cancer status post total thyroidectomy underwent the second I radioiodine ablation therapy for lung metastases. Posttherapeutic whole-body I planar images showed diffuse uptake in the lungs and intense focal activity in both sides of the upper abdomen. SPECT/CT of the abdomen localized the uptake in the upper pole of the left kidney and the lower pole of the right kidney. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001745DOI Listing
September 2017
7 Reads

Two Cases of Tuberous Sclerosis Complex Suggestive of Complicating Multifocal Micronodular Pneumocyte Hyperplasia: A Case Report.

J UOEH 2017;39(2):133-141

Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health.

Multifocal micronodular pneumocyte hyperplasia (MMPH) is pathologically characterized by multifocal nodular hyperplasia of type Ⅱ pneumocyte-like cells. MMPH is usually complicated with tuberous sclerosis complex (TSC). MMPH patients tend to be asymptomatic or only slightly symptomatic. Read More

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http://dx.doi.org/10.7888/juoeh.39.133DOI Listing
October 2017
23 Reads

The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas.

Rev Port Pneumol (2006) 2017 Sep - Oct;23(5):280-286. Epub 2017 Jun 1.

Department of Pulmonology, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Maltepe, İstanbul, Turkey.

Purpose: To investigate the frequency of lung cancer in patients with pulmonary hamartomas and to evaluate clinical, radiological, and pathological characteristics of pulmonary hamartomas.

Basic Procedures: We reviewed pathology records of pulmonary hamartomas diagnosed between 2003 and 2014. Medical records and the hospital electronic database were also reviewed for each patient to obtain clinical, radiological, and pathological characteristics of pulmonary hamartomas and accompanying malignancies. Read More

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http://dx.doi.org/10.1016/j.rppnen.2017.04.008DOI Listing
June 2018
7 Reads

Mesenchymal cystic hamartoma of the lung.

Respir Med Case Rep 2017 12;21:158-160. Epub 2017 May 12.

Department of Pulmonary-Critical Care, Allegheny General Hospital, Pittsburgh, 320 E North Ave, Pittsburgh, PA 15212, USA.

Mesenchymal cystic hamartoma, although first reported as early as 1980s, remains a very rare lung disease. There have been less than 20 cases reported to date. Mesenchymal cystic hamartoma usually has an indolent course, but it could potentially result in morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.rmcr.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435595PMC
May 2017
8 Reads

Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis complex: A case report without lymphangioleiomyomatosis association.

Rev Port Pneumol (2006) 2017 Jul - Aug;23(4):239-240. Epub 2017 May 25.

Department of Radiology, Manchester Royal Infirmary, Central Manchester University Hospitals, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.rppnen.2017.04.004DOI Listing
January 2019
2 Reads

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

Cancer Res 2017 06 16;77(12):3255-3267. Epub 2017 May 16.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes tuberous sclerosis complex (TSC)1 or TSC2. Here we report that p62 is a critical mediator of TSC2-driven tumorigenesis, as Tsc2 and Tsc2f/f Ksp-CreERT2 mice crossed to p62 mice were protected from renal tumor development. Metabolic profiling revealed that depletion of p62 in Tsc2-null cells decreased intracellular glutamine, glutamate, and glutathione (GSH). Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485875PMC
June 2017
70 Reads