1,875 results match your criteria Hamartoma Lung

Surgical techniques and outcome analysis of uniportal video-assisted thoracic surgery complex sleeve lung resection: a 20 case-series study.

J Thorac Dis 2021 Apr;13(4):2255-2263

Department of Thoracic Surgery, Shang Hai Pulmonary Hospital, Shanghai, China.

Background: Our study aims to explore the feasibility of uniportal video-assisted complex sleeve lung resection and summarize the surgical techniques and clinical outcomes.

Methods: From June 2016 to April 2020, a total of 20 complex sleeve pulmonary and distal tracheal resections were performed by the single surgical team at the Thoracic Surgery Department of the Shanghai Pulmonary Hospital. We defined cases as complex sleeve pulmonary resections if they required pulmonary segment sleeve resection, extended sleeve resection (lobectomy plus segmentectomy of the remaining lobe), sleeve pneumonectomy, lobectomy plus carinoplasty or neo-carina construction, pulmonary-sparing main bronchus resection plus carina reconstruction, and distal trachea resection with end to end anastomosis. Read More

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ALK-negative lung inflammatory myofibroblastic tumor in a young adult: A case report and literature review of molecular alterations.

Medicine (Baltimore) 2021 May;100(20):e25972

Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori," Meldola.

Rationale: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is prevalent among children and adolescents. Surgery is the most important therapeutic approach for IMT and complete resection is recommended. Although 50% of IMTs show anaplastic lymphoma kinase (ALK) rearrangements, crizotinib has proven an effective therapeutic approach. Read More

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and Genotype in Tuberous Sclerosis Complex: Are Other Manifestations of this Multisystem Disease Affected by Genotype?

Ann Am Thorac Soc 2021 05;18(5):775-777

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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Interlobar Pulmonary Hamartoma With an Unusual Neighboring Lesion: A Case Report.

Cureus 2021 Mar 20;13(3):e14008. Epub 2021 Mar 20.

Internal Medicine, Salmaniya Medical Complex, Manama, BHR.

Pulmonary hamartomas are benign lung tumors. They are uncommon and represent a small percentage of all solitary lung lesions. Hamartomas are composed of an abnormal mixture of epithelial and mesenchymal elements. Read More

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Histopathological Features of Fibrous Cephalic Plaques in Tuberous Sclerosis Complex.

Histopathology 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Background: Fibrous cephalic plaques (FCPs) in individuals with tuberous sclerosis complex (TSC) may be excised for cosmetic reasons or biopsied to confirm lesion identification and TSC diagnosis.

Aim: To determine the range of histopathological features of FCPs.

Methods: A retrospective analysis was conducted on 119 adults with TSC. Read More

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Endobronchial Hamartoma Presenting as Recurrent Pneumonia and Chronic Cough.

Cureus 2021 Mar 5;13(3):e13717. Epub 2021 Mar 5.

Pulmonary and Critical Care, Jersey Shore University Medical Center, Neptune, USA.

Pneumonia is an infection of the lungs that can result from various etiologies, including bronchial obstruction. It is estimated that 5.4% of community-acquired pneumonia occurs as a result of an endobronchial obstruction, classifying them as post-obstructive pneumonia. Read More

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[Seromucinous hamartoma in the lung: report of a case].

X G Hu W Wang X L He

Zhonghua Bing Li Xue Za Zhi 2021 Apr;50(4):397-399

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

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Lung adenocarcinoma mimicking hamartoma on CT.

Diagn Interv Imaging 2021 Mar 18. Epub 2021 Mar 18.

Department of Radiology, Hôpital Cochin, AP-HP centre, 75014 Paris, France; Université de Paris, 75006 Paris, France. Electronic address:

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Clock dial integrated positioning combined with single utility port video-assisted thoracoscopic surgery: a new localization method for lung tumors.

J Thorac Dis 2021 Feb;13(2):1143-1150

Department of Cardiothoracic Surgery, Dehong People's Hospital, Affiliated Dehong People's Hospital of Kunming Medical University, Dehong, China.

Background: Preoperative localization of lung tumor mainly consisted of two methods: CT-guided percutaneous localization and electromagnetic navigation bronchoscopy-guided localization. However, these invasive methods could result in serious complications. In order to avoid the adverse effects of preoperative invasive localization, we propose a method of intraoperative noninvasive localization for lung tumors: clock dial integrated positioning (CDIP). Read More

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February 2021

A Rare Case of Benign Hamartoma and Malignant Primary Pulmonary Lymphoma Coexisting in a Patient Mimicking Invasive Pulmonary Mycosis: a Case Report and Literature Review.

Clin Lab 2021 Feb;67(2)

Background: Pulmonary hamartomas are the most common benign tumors of the lungs and can occur anywhere in the lungs, normal hyperplasia, congenital malformation, inflammatory changes, and tumorigenesis are hypothesized to underlie the pathogeny, but the definite etiology remains to be elucidated. Primary pulmonary lymphoma (PPL) refers to clonal lymphoid hyperplasia of one or both lungs in patients who have no detectable extrapulmonary lymphoma or bone marrow involvement at the time of diagnosis and during the subsequent 3 months. It is rare for both diseases to occur in the lungs of the same patient. Read More

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February 2021

The tuberous sclerosis complex-associated giant renal angiomyolipoma: A case report.

Mol Clin Oncol 2021 Mar 21;14(3):52. Epub 2021 Jan 21.

Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.

Renal angiomyolipoma (RAML), also referred to as renal hamartoma, is a rare benign tumor. There are two types of RAML, which include the tuberous sclerosis complex (TSC)-associated type and the sporadic type. TSC is an autosomal dominant genetic disease characterized by the growth of benign tumors in the skin, brain, kidneys, lung and heart. Read More

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Miliary fibromas in tuberous sclerosis complex.

J Eur Acad Dermatol Venereol 2021 May 23;35(5):1226-1229. Epub 2021 Feb 23.

Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Background: Tuberous sclerosis complex (TSC) is a hamartoma syndrome characterized by multiple skin lesions, such as angiofibromas, shagreen patch and miliary fibromas (MiF).

Objective: To determine the clinical and histological features of MiF.

Methods: A retrospective analysis was conducted on 133 adults with TSC. Read More

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A pulmonary hamartoma in Covid-19 pneumonia: an interesting case studied with computed tomography.

Radiol Case Rep 2021 Apr 31;16(4):942-944. Epub 2021 Jan 31.

Unit of Radiology, Riuniti Hospital, Azienda Ospedaliera Grande Ospedale Metropolitano (G.O.M.) "Bianchi-Melacrino-Morelli", Via Giuseppe Melacrino n.21, 89124 Reggio Calabria, Italy.

Since the widespread of acute respiratory syndrome infection caused by Coronavirus-19, chest computed tomography (CT) was considered a useful imaging tool commonly used in early diagnosis and monitoring of patients with complicated Covid-19 pneumonia. Many typical imaging features of this disease were carefully described with chest CT, as well as the collateral CT findings in the lungs and mediastinum. Here we describe the case of a patient with Covid-19 pneumonia, that collaterally had a pulmonary hamartoma in the left lung, documented at CT. Read More

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Transretinal biopsy via 23-gauge pars plana vitrectomy for retinal and choroidal tumors: cytopathological results, surgical complications, and patient outcomes.

Jpn J Ophthalmol 2021 Mar 9;65(2):250-260. Epub 2021 Jan 9.

Department of Biostatistics, Ankara University Faculty of Medicine, Ankara, Turkey.

Purpose: To evaluate the cytopathological results, surgical complications, and patient outcomes after transretinal biopsy (TRB) for diagnosis of retinal/choroidal tumors METHODS: Records of 40 cases who underwent TRB via 23-gauge (23 G) pars plana vitrectomy between March 2011 and March 2020 were reviewed.

Study Design: Retrospective.

Results: Twenty-six (65. Read More

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Application of ultrasound in a congenital cystic adenomatoid malformation in an adult: A case report.

Medicine (Baltimore) 2020 Dec;99(49):e23505

Department of Ultrasound, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Introduction: Congenital cystic adenomatoid malformation (CCAM) is a rare developmental lung abnormality, that typically manifests in neonates and infants but rarely in adults. Ultrasound is an important method of diagnosing CCAM in neonates and infants; however, few articles have reported the value of transthoracic lung ultrasound in the diagnosis of CCAM in adults.

Patient Concerns: We present a case of a 34-year-old woman with a cavitary lesion in her left lower lobe, that suggested chronic inflammation. Read More

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December 2020

Clinical, Radiologic, and Pathologic Characteristics of Pulmonary Hamartomas With Uncommon Presentation.

Am J Clin Pathol 2021 May;155(6):903-911

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN.

Objectives: To investigate the clinicopathologic and radiologic features of pulmonary hamartomas (PHs) with uncommon clinical presentation.

Methods: A retrospective clinicopathologic and radiologic review was performed for patients diagnosed (1999-2019) with multiple hamartomas, lesions arising adjacent to a coexisting pulmonary malignancy, and tumors with predominantly extrapulmonary localization.

Results: Of 979 patients diagnosed with PHs, 6 (0. Read More

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The Usefulness of Imaging Quantification in Discriminating Non-Calcified Pulmonary Hamartoma From Adenocarcinoma.

Front Oncol 2020 22;10:568069. Epub 2020 Oct 22.

Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Patients with non-calcified hamartoma were more susceptible to surgery or needle biopsy for the tough discrimination from lung adenocarcinoma. Radiomics have the ability to quantify the lesion features and potentially improve disease diagnosis. Thus, this study aimed to discriminate non-calcified hamartoma from adenocarcinoma by employing imaging quantification and machine learning. Read More

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October 2020

The Imaging Features of Tuberous Sclerosis in African Children:A Pictorial Essay.

West Afr J Med 2020 Nov;37(6):671-679

Department of Radiology,Nelson Mandela Children Hospital,Johannesburg. South Africa.

Tuberous sclerosis (TS) is a neurocutaneous syndrome with an autosomal dominant inheritance characterized by widespread hamartomas and benign neoplasms distributed in several organs throughout the body. The mean age of presentation is 5 years and the imaging features tend to vary with age. The most commonly affected organs include the brain, skin, retina, kidney, bones, heart and lung. Read More

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November 2020

A 47-Year-Old Woman With Pulmonary Nodules and Facial Hemispasms.

Chest 2020 10;158(4):e197-e204

Respiratory Center, Asahikawa Medical University Hospital, Japan.

Case Presentation: A 47-year-old woman visited her primary physician for a health check, and some radiographic abnormalities were detected. She was referred to our division for further management. In recent years, she had become conscious of occasional facial hemispasms. Read More

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October 2020

A novel TSC2 c.4511 T > C missense variant associated with tuberous sclerosis complex.

BMC Med Genet 2020 09 11;21(1):180. Epub 2020 Sep 11.

Electrocardiogram Room, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, 264000, P.R. China.

Background: Tuberous sclerosis complex (TSC) is an autosomal-dominant hereditary disease characterized by hamartomas of multiple organ systems, including the brain, skin, heart, kidney and lung. Genetically, TSC is caused by pathogenic variants in the TSC1 or TSC2 gene.

Case Presentation: We reported a sporadic case of a 32-year-old Han Chinese male diagnosed with TSC, whose spouse had a history of two spontaneous miscarriages and an induced abortion of a 30-week fetus identified with cardiac rhabdomyoma by ultrasound. Read More

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September 2020

Endobronchial hamartoma coexisting with lung cancer.

Respirol Case Rep 2020 Oct 18;8(7):e00643. Epub 2020 Aug 18.

Department of Cardiology, Pulmonology, Hypertension and Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan.

Clinicians should be careful when examining a case with endobronchial hamartoma with concurrent malignant disease because radiographic imaging and symptoms cannot clearly differentiate between both diseases. Read More

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October 2020

Malignant transformation of inflammatory myofibroblastic tumor of urinary bladder: A rare case scenario.

Bladder (San Franc) 2019 26;6(2):e39. Epub 2019 Dec 26.

Department of Pathology, RWJBarnabas Health, Livingston, NJ, USA.

Inflammatory myofibroblastic tumor (IMT) previously known as inflammatory pseudotumor, plasma cell granuloma, pseudosarcoma, myxoid hamartoma or inflammatory myofibrohistiocytic proliferation is recently recognized by World Health Organization (WHO) as "IMT" and is considered as a rare benign tumor of soft tissues occurring commonly in lung, liver and mesentry and omentum. IMT is mainly identified as a lesion of children and young population. In this report, we describe a rare case of IMT occurring in a 93-year-old female in urinary bladder with initial benign presentation but demonstrating rapid malignant transformation as confirmed with morphology and immunohistochemical (IHC) stains. Read More

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December 2019

[Clinical-radiological-pathological Characteristics of 297 Cases of Surgical Pathology Confirmed Benign Pulmonary Lesions in Which Malignancy Could Not Be Excluded in Preoperative Assessment: A Retrospective Cohort Analysis in a Single Chinese Hospital].

Zhongguo Fei Ai Za Zhi 2020 Sep 10;23(9):792-799. Epub 2020 Aug 10.

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Low dose computed tomography (LDCT) for lung cancer screening is widely employed in China as a result of increasing cancer screening awareness. Although some pulmonary lesions detected by LDCT are cancerous, most of the pulmonary nodules are benign. It is important to make effective preoperative differentiation of pulmonary lesions and to obviate the need for surgery in some patients with benign disease. Read More

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September 2020

Genetics of tuberous sclerosis complex: an update.

Daphna Marom

Childs Nerv Syst 2020 10 6;36(10):2489-2496. Epub 2020 Aug 6.

Human Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Purpose: To review the current genetic aspects of tuberous sclerosis complex.

Methods: Review of the literature.

Results: Tuberous sclerosis complex (TSC), a long known childhood-onset monogenic disorder, characterized by hamartoma formation affecting mainly the brain, heart, kidney, lung, and skin, is associated with a high morbidity burden and risk of a reduced life span. Read More

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October 2020

Lung cancer reported as a benign lesion due to low-dose chest computed tomography artefact: A case report.

J Med Imaging Radiat Oncol 2020 Dec 27;64(6):821-823. Epub 2020 Jul 27.

Department of Medical Imaging, Fiona Stanley Hospital, Perth, Western Australia, Australia.

CT imaging for lung cancer screening requires low dose technique. Low dose CT chest imaging is associated with an increased risk of artefacts, such as increased noise. We present a case where an artefact from the low dose technique lead to a lung cancer being erroneously reported as a benign hamartoma. Read More

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December 2020

Mucinous Adenomyomatous Pulmonary Hamartoma: Clinicopathologic, Immunohistochemical, and Molecular Features of 6 Cases.

Int J Surg Pathol 2021 May 27;29(3):273-280. Epub 2020 Jul 27.

Mayo Clinic Arizona, Scottsdale, AZ, USA.

Pulmonary hamartoma (PH) may show various combinations of mesenchymal tissues with entrapment of respiratory epithelium. An uncommon variant of PH prevalently consisting of smooth muscle with mucinous proliferation has been reported in literature under several definitions as sporadic reports. We collected a series of 6 leiomyomatous PH associated with mucinous growth from consultation files (3 cases) and multicentric revision of archival files among 128 consecutive surgically resected PH. Read More

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Two cases of nodular smooth muscle proliferation suspected of primary lung cancer from preoperative images: a case report.

J Cardiothorac Surg 2020 Jul 22;15(1):179. Epub 2020 Jul 22.

Faculty of Medicine, Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Kagawa University, 1750-1 Ikenobe, Kita-gun, Miki-cho, Kagawa, 761-0793, Japan.

Background: It is difficult to obtain a definitive diagnosis for nodular smooth muscle proliferation (NSMP) before surgery, and a pathological diagnosis is necessary to differentiate it from primary lung cancer. We report two cases of NSMP that were suspected to be primary lung cancer on preoperative images.

Case Presentation: Case 1: An 81-year-old man who had undergone right upper lobectomy for lung cancer 2 years earlier was point out a nodular shadow with ground glass opacity (GGO) in the lower right lobe, suggesting a second primary lung cancer by chest computed tomography (CT). Read More

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Cryptosporidium baileyi Pulmonary Infection in Immunocompetent Woman with Benign Neoplasm.

Emerg Infect Dis 2020 08;26(8):1958-1961

Cryptosporidium baileyi, a bird-specific parasite, infects gastrointestinal, pulmonary, and urinary tracts of its host. We report on a C. baileyi infection associated with pulmonary hamartoma in an immunocompetent patient in Poland. Read More

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Chronic kidney disease caused by tuberous sclerosis complex: lymphangioleiomyomatosis diagnosed in an adult woman.

Pol Arch Intern Med 2020 10 6;130(10):895-897. Epub 2020 Jul 6.

Department of Nephrology, Jagiellonian University Medical College, Kraków, Poland.

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October 2020

Video-assisted thoracoscopic apicoposterior segmentectomy.

Multimed Man Cardiothorac Surg 2020 Jun 25;2020. Epub 2020 Jun 25.

Thoracic Surgery Department, Hospital Privado Universitario de Córdoba, Córdoba, Argentina.

Anatomic segmentectomy is a form of sublobar resection that can be both diagnostic and therapeutic in the context of an indeterminate pulmonary nodule, suspected metastasis, or small peripheral cancer.  This video tutorial demonstrates our technique for an apicoposterior anatomical segmentectomy performed by video-assisted thoracoscopy, using two ports, for resection of an undiagnosed pulmonary nodule. The steps performed by the surgical team are shown, and we pay particular attention to the recognition of vascular anatomy. Read More

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