10,283 results match your criteria Halo Nevus


Silencing of microRNA-27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK-dependent mTOR signaling pathway.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China.

Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore, this study aims to identify the role of microRNA-27a (miR-27a) in autophagy and apoptosis of melanoma cells in regulating spleen tyrosine kinase (SYK)-mediated the mammalian target of rapamycin (mTOR) signaling pathway. Read More

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http://dx.doi.org/10.1002/jcb.28600DOI Listing

Tattoo pigment removal by halo nevus phenomenon.

JAAD Case Rep 2019 Apr 30;5(4):317-318. Epub 2019 Mar 30.

Metrohealth Medical Center and Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2018.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441708PMC

A Man with Juvenile Nasopharyngeal Angiofibroma, Vestibular Schwannoma, Cleft Lip and Cleft Palate, and Various Nevi: Case Report and Review.

Cureus 2018 Sep 14;10(9):e3304. Epub 2018 Sep 14.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Juvenile nasopharyngeal angiofibroma is a vascular tumor that typically occurs in men. Vestibular schwannoma (acoustic neuroma) is a tumor affecting the vestibulocochlear nerve. A 38-year-old man with various pigmented lesions and history of juvenile nasopharyngeal angiofibroma, vestibular schwannoma, and cleft lip and cleft palate is described. Read More

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http://dx.doi.org/10.7759/cureus.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417465PMC
September 2018
1 Read

A white ring around a naevus.

Authors:
Fei Han Fei Wang

BMJ 2019 Mar 14;364:l997. Epub 2019 Mar 14.

Department of Dermatology, Zhongda Hospital, Southeast University, Nanjing City, Jiangsu Province, China.

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http://dx.doi.org/10.1136/bmj.l997DOI Listing

A case of woolly hair nevus, multiple linear pigmentation, and epidermal nevi with somatic HRAS p.G12S mutation.

Pediatr Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Woolly hair nevus is a rare syndrome that presents as woolly hair in restricted areas of the scalp and may be associated with pigmented macules or epidermal nevus on the body. Here, we report a case of woolly hair nevus, linear pigmentation, and multiple epidermal nevi with a somatic HRAS c.34G>A(p. Read More

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http://dx.doi.org/10.1111/pde.13783DOI Listing

Evolution of congenital melanocytic nevi toward benignity: A case series.

Pediatr Dermatol 2019 Mar 6;36(2):227-231. Epub 2019 Mar 6.

Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.

We report on four children born with medium to large congenital melanocytic nevi (CMN) with color heterogeneity and irregular surface rugosity. As these patients aged, their nevi evolved to become more homogeneous and lighter in color, and developed a smoother, more even texture. We propose that given this evolution toward benignity, conservative monitoring and management may be appropriate even in the context of atypical-appearing features at birth. Read More

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http://dx.doi.org/10.1111/pde.13745DOI Listing
March 2019
1 Read

[Clinicopathological features and prognosis of ALK-positive Spitz tumors].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):215-219

Clinical Pathological Diagnosis Center of Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and prognosis of ALK-positive Spitz tumors. Thirteen patients with ALK-positive Spitz tumors diagnosed at Shanghai Cancer Center, Fudan University from October 2016 to December 2017 were collected. All cases were routinely evaluated histopathological features in HE staining and detected ALK protein expression by immunohistochemistry. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.009DOI Listing
March 2019
10 Reads

Perinevoid Alopecia: A Case Report.

Skin Appendage Disord 2019 Feb 18;5(2):94-96. Epub 2018 Jul 18.

Department of Dermatopathology, "Dr. Manuel Gea González" General Hospital, Mexico City, Mexico.

Perinevoid alopecia has been described as an associated alopecia surrounding a pigmented nevus due to an inflammatory response against nevus structures. It is described as a part of other nevocentric phenomena in which a cellular inflammatory response against nevus antigens develops. A 35-year-old male presented with a unique area of non-scarring alopecia surrounding an asymptomatic, pigmented nevus with a 1-month evolution. Read More

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http://dx.doi.org/10.1159/000490469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388562PMC
February 2019
2 Reads

Isolated straight hair nevus in a White child.

Pediatr Dermatol 2019 Mar 21;36(2):260-261. Epub 2019 Feb 21.

Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin Diseases, INSERM U 1035, University of Bordeaux, Bordeaux, France.

We report a 6-month-old girl born with a fronto-parietal patch of hair straighter than the remainder of the scalp hairs. We took a biopsy to rule out a congenital melanocytic nevus. We concluded after additional scanning electron microscopy study of the hair shafts that the lesion corresponds to a possible local mosaicism causing an isolated straight hair nevus phenotype. Read More

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http://dx.doi.org/10.1111/pde.13740DOI Listing
March 2019
2 Reads

Lasers for Becker's nevus.

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Becker's nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker's nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. Read More

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http://dx.doi.org/10.1007/s10103-019-02734-3DOI Listing
February 2019
12 Reads

[The application of modified rhomboid flap in repairing facial skin and soft tissue defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 02;33(2):207-211

Department of Plastic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.

Objective: To explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.

Methods: Between January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201810020
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http://dx.doi.org/10.7507/1002-1892.201810020DOI Listing
February 2019
3 Reads

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
February 2019
1 Read

Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 4;257(4):835-841. Epub 2019 Feb 4.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Purpose: This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM).

Methods: Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Read More

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http://dx.doi.org/10.1007/s00417-019-04257-7DOI Listing

Extremity nevus count is an independent risk factor for basal cell carcinoma and melanoma, but not squamous cell carcinoma.

J Am Acad Dermatol 2019 Apr 31;80(4):970-978. Epub 2019 Jan 31.

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana; Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana. Electronic address:

Background: The presence of nevi portends an increased risk for melanoma.

Objective: We sought to examine the association between extremity nevus count and the risk of melanoma and keratinocyte cancers.

Methods: We evaluated prospective cohorts of 176,317 women (the Nurses' Health Study, 1986-2012 and the Nurses' Health Study 2, 1989-2013) and 32,383 men (Health Professionals Follow-up Study, 1986-2012). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183265
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http://dx.doi.org/10.1016/j.jaad.2018.09.044DOI Listing
April 2019
11 Reads

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Mar 29;13(1):56-70. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406009PMC
March 2019
4 Reads

Multiple melanocytic nevi restricted to mycosis fungoides patches in pediatric and young-adult patients. The potential role of local immunosuppression.

Pediatr Dermatol 2019 Mar 18;36(2):232-235. Epub 2019 Jan 18.

Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

We described the development of multiple melanocytic nevi within long-standing MF patches in four young patients. Mycosis fungoides (MF) patches are characterized by a regulatory-like cytokine profile leading to local immune suppression. The proliferation of nevomelanocytes is regulated by cellular senescence mechanisms mediated by immune system. Read More

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http://dx.doi.org/10.1111/pde.13738DOI Listing
March 2019
4 Reads

Clinicopathologic, misdiagnosis, and survival differences between clinically amelanotic melanomas and pigmented melanomas.

J Am Acad Dermatol 2019 May 14;80(5):1292-1298. Epub 2019 Jan 14.

Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Amelanotic malignant melanoma (AMM) is challenging to diagnose. Clinical risk factors for AMM are not well defined.

Objective: To investigate clinicopathologic, misdiagnosis, and survival differences between patients with AMM and those with pigmented malignant melanoma (PMM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193008
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http://dx.doi.org/10.1016/j.jaad.2019.01.012DOI Listing
May 2019
17 Reads
4.449 Impact Factor

Hyperspectral imaging in automated digital dermoscopy screening for melanoma.

Lasers Surg Med 2019 Mar 17;51(3):214-222. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

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http://doi.wiley.com/10.1002/lsm.23055
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http://dx.doi.org/10.1002/lsm.23055DOI Listing
March 2019
42 Reads

[Repair of skin and soft tissue defects of auricle and donor site with relay flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 01;33(1):66-69

Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China.

Objective: To investigate the effectiveness of relay flap on repairing skin and soft tissue defect of auricle and donor site.

Methods: Between May 2014 and January 2016, 10 patients with auricular tumor were repaired by relay flap. There were 4 males and 6 females with an average age of 35 years (range, 21-69 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807141
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http://dx.doi.org/10.7507/1002-1892.201807141DOI Listing
January 2019
19 Reads

Orbital Hemangioma in Bean Syndrome: The Lure of the Red Herring.

World Neurosurg 2019 Mar 18;123:272-280. Epub 2018 Dec 18.

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Bean syndrome (BS) is a rare congenital low-flow angiomatosis affecting multiple organ systems. About 200 cases with heterogeneous clinical presentation have been reported worldwide. The exact etiopathology is still not known. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.257DOI Listing
March 2019
1 Read
2.417 Impact Factor

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
15 Reads

Lethal melanoma in a two-year-old child with multiple congenital melanocytic nevi.

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):89-93

Department of Dermatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_938_17DOI Listing
April 2019
3 Reads

Histopathologic correlation of high-risk MelaFind lesions: a 3-year experience from a high-risk pigmented lesion clinic.

Int J Dermatol 2019 May 13;58(5):569-576. Epub 2018 Dec 13.

Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.

Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14336
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http://dx.doi.org/10.1111/ijd.14336DOI Listing
May 2019
13 Reads

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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http://dx.doi.org/10.1177/0009922818816421DOI Listing
December 2018
3 Reads

A Deep Learning Approach to Vascular Structure Segmentation in Dermoscopy Colour Images.

Biomed Res Int 2018 1;2018:5049390. Epub 2018 Nov 1.

Department of Automatic Control and Robotics, AGH University of Science and Technology, Cracow, Poland.

Background: Atypical vascular pattern is one of the most important features by differentiating between benign and malignant pigmented skin lesions. Detection and analysis of vascular structures is a necessary initial step for skin mole assessment; it is a prerequisite step to provide an accurate outcome for the widely used 7-point checklist diagnostic algorithm.

Methods: In this research we present a fully automated machine learning approach for segmenting vascular structures in dermoscopy colour images. Read More

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https://www.hindawi.com/journals/bmri/2018/5049390/
Publisher Site
http://dx.doi.org/10.1155/2018/5049390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236870PMC
March 2019
20 Reads

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

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http://www.j-smu.com/oa/darticle.aspx?type=view&id=20181
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http://dx.doi.org/10.12122/j.issn.1673-4254.2018.11.14DOI Listing
November 2018
17 Reads

Cross-contamination of pathology specimens: a cautionary tale.

Cutis 2018 Oct;102(4):E12-E14

Departments of Dermatology and Pathology, Stanford Hospital and Clinics, Redwood City, California, USA.

There are many potential sources of error in clinical practice. An astute clinician must not only work hard to prevent errors but also minimize harmful sequelae that could arise from errors that do occur. A rare but real source of error is cross-contamination of pathology specimens. Read More

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October 2018
15 Reads

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

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http://dx.doi.org/10.1002/jcb.28124DOI Listing
November 2018
2 Reads

Vertical plane ex vivo dermoscopy: a novel dermoscopic technique. A preliminary study.

An Bras Dermatol 2018 Nov/Dec;93(6):899-901

Department of Pathology, Santa Casa de São Paulo, São Paulo (SP), Brazil.

Dermoscopic examination allows visualization of horizontal images on the skin, showing well-defined patterns. The authors propose ex vivo dermoscopic visualization using a vertical view of skin sections. The new image clearly distinguishes the stratum corneum, epidermis, and dermis as well as the anatomical location of the pigment. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256214PMC
February 2019
2 Reads

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

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http://dx.doi.org/10.4103/jovr.jovr_215_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210859PMC
November 2018
5 Reads

NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 12 18;38(6). Epub 2018 Dec 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Melanoma-conditioned TAMs were obtained from human monocytes after incubation with conditioned medium from A375 cell culture. Read More

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http://dx.doi.org/10.1042/BSR20181604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435508PMC
December 2018
8 Reads

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

Nat Commun 2018 11 14;9(1):4774. Epub 2018 Nov 14.

QIMR Berghofer Medical Research Institute, Brisbane, Australia.

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. Read More

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http://www.nature.com/articles/s41467-018-06649-5
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http://dx.doi.org/10.1038/s41467-018-06649-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235897PMC
November 2018
20 Reads
10.742 Impact Factor

Correlation of Vascular Endothelial Growth Factor subtypes and their receptors with melanoma progression: A next-generation Tissue Microarray (ngTMA) automated analysis.

PLoS One 2018 8;13(11):e0207019. Epub 2018 Nov 8.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Introduction: Finding new markers to assess prognosis of melanoma without the necessity to perform a surgical interventions is an important goal in melanoma research. The current study aimed to assess the correlation of clinical course and prognosis of primary and metastatic melanoma with expression of VEGF family and their receptors.

Methods: A ngTMA block was made from the randomly selected paraffin tissue blocks of the patients with melanocytic nevi, primary and metastatic melanoma. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207019PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224082PMC
April 2019
12 Reads

Nevus cells of cardiofaciocutaneous syndrome bear BRAF germ-line and somatic double mutations.

Eur J Dermatol 2018 Oct;28(5):704-705

Department of Dermatology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan.

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http://dx.doi.org/10.1684/ejd.2018.3375DOI Listing
October 2018
2 Reads

Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis.

Cutis 2018 Sep;102(3):E2-E4

Department of Dermatology, University of Virginia, Charlottesville, USA.

Nevus of Ota is a blue, hyperpigmented, benign dermatosis of the skin and mucosae that most often occurs unilaterally in the distribution of the ophthalmic (V1) and maxillary (V2) branches of the trigeminal nerve. Although uncommon, association with malignant melanoma is a complication that must be considered in the evaluation of patients with nevus of Ota. Mutations in the and genes in patients with nevus of Ota place them at higher risk for malignant melanoma and metastasis. Read More

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September 2018
5 Reads

Pigmented Lesions of the Nail Unit.

Am J Dermatopathol 2018 Nov;40(11):793-804

Faculty in Dermatopathology, Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Pigmented lesions of the nail unit are commonly encountered in the clinical setting. Yet, they often present a unique challenge to clinicians because of a broad differential diagnosis or unfamiliarity with clinical and histopathologic features. A wide variety of causes exist ranging from benign lesions such as subungual hemorrhage to malignant lesions such as subungual melanoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001106DOI Listing
November 2018
4 Reads

A novel cumulative level difference mean based GLDM and modified ABCD features ranked using eigenvector centrality approach for four skin lesion types classification.

Comput Methods Programs Biomed 2018 Oct 24;165:163-174. Epub 2018 Aug 24.

Department of Electronics and Electrical Communications Engineering, Faculty of Engineering, Tanta University, Tanta, Egypt.

Background And Objective: Melanoma is one of the major death causes while basal cell carcinoma (BCC) is the utmost incident skin lesion type. At their early stages, medical experts may be confused between both types with benign nevus and pigmented benign keratoses (BKL). This inspired the current study to develop an accurate automated, user-friendly skin lesion identification system. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.08.009DOI Listing
October 2018
3 Reads

Defining the Molecular Genetics of Dermoscopic Naevus Patterns.

Dermatology 2019 17;235(1):19-34. Epub 2018 Oct 17.

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland,

Melanocytic naevi are common melanocytic proliferations that may simulate the appearance of cutaneous melanoma. Naevi commonly harbour somatic mutations implicated in melanomagenesis but in most cases lack the necessary genomic alterations required for melanoma development. While the mitogen-activated protein kinase pathway and ultraviolet radiation strongly contribute to naevogenesis, the somatic mutational landscape of dermoscopic naevus subsets distinguishes some of the molecular hallmarks of naevi in relation to melanoma. Read More

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https://www.karger.com/Article/FullText/493892
Publisher Site
http://dx.doi.org/10.1159/000493892DOI Listing
March 2019
1 Read

Distinct MAPK and PI3K pathway mutations in different melanoma types in Taiwanese individuals.

Eur J Dermatol 2018 Aug;28(4):509-518

Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.

Background: A number of studies investigating mutations of genes involved in MAPK and PI3K pathways in melanoma patients have been performed, most of which were based on Caucasian populations.

Objectives: We sought to identify BRAF, NRAS, MEK1, PI3K, and PTEN mutations and further determine possible correlations with clinicopathological parameters in Taiwanese patients with acral, non-chronic sun damaged (NCSD), or mucosal melanoma.

Materials & Methods: Forty melanocytic nevi, 24 dysplastic nevi, and 175 melanomas from Taiwanese patients were analysed for mutations in BRAF, NRAS, MEK1, PI3K, and PTEN genes by PCR and direct sequencing. Read More

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http://dx.doi.org/10.1684/ejd.2018.3359DOI Listing
August 2018
1 Read

Malignant Transformation of a Multi-Operated Divided Nevus of the Eyelids.

Ocul Oncol Pathol 2018 Sep 2;4(2):112-115. Epub 2017 Sep 2.

Institut Curie, Institut Curie, Paris, France.

A woman in her early fifties had regular follow-up for a medium-sized divided nevus of the eyelids which had undergone several surgical excisions during childhood for functional and esthetic reasons. Malignant transformation of the nevus occurred in the inferior eyelid, with the appearance of a new pigmented flat lesion. Histology showed in situ melanoma, and an NRAS activating mutation was found. Read More

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https://www.karger.com/Article/FullText/479069
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http://dx.doi.org/10.1159/000479069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167659PMC
September 2018
4 Reads

Inconsistent distortion in ultra-widefield fundus image.

Acta Ophthalmol 2019 Mar 14;97(2):e326-e327. Epub 2018 Oct 14.

Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/aos.13951DOI Listing

Agminated blue nevus with a GNAQ mutation: A case report and review of the literature.

J Cutan Pathol 2019 Feb 19;46(2):130-133. Epub 2018 Nov 19.

Department of Dermatology, University of California, San Diego, California.

Agminated blue nevi are dermal melanocytic proliferations that classically present as dark blue macules or papules in a grouped, linear, or blaschkoid distribution. In their more common sporadic form, blue nevi manifest in young adulthood as solitary blue papules or macules on the scalp, face, hands, or feet. By contrast, agminated blue nevi tend to manifest earlier in life, and are distributed more evenly across anatomic sites. Read More

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http://doi.wiley.com/10.1111/cup.13373
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http://dx.doi.org/10.1111/cup.13373DOI Listing
February 2019
18 Reads

Melanocytic lesions - Staying out of trouble.

Authors:
Thomas Brenn

Ann Diagn Pathol 2018 Dec 27;37:91-102. Epub 2018 Sep 27.

Department of Pathology & Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary AB T2L 2K8, Canada; Department of Pathology, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, United Kingdom. Electronic address:

The diagnosis of melanocytic tumors is notoriously difficult and represents one of the most challenging areas in surgical pathology associated with significant risk for litigation. One reason is the wide morphologic spectrum of melanocytic tumors and the fact that many histological features are shared by both benign melanocytic nevi and melanoma. Awareness of the many morphologic variations and variants of nevi and melanoma, their clinical setting, immunohistochemical phenotype and genetic profile is necessary for the correct diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.010DOI Listing
December 2018
8 Reads

Risk of Subsequent Cutaneous Melanoma in Moderately Dysplastic Nevi Excisionally Biopsied but With Positive Histologic Margins.

JAMA Dermatol 2018 Dec;154(12):1401-1408

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Little evidence exists to guide the management of moderately dysplastic nevi excisionally biopsied without residual clinical pigmentation but with positive histologic margins (hereafter referred to as moderately dysplastic nevi with positive histologic margins).

Objective: To determine outcomes and risk for the development of subsequent cutaneous melanoma (CM) from moderately dysplastic nevi with positive histologic margins observed for 3 years or more.

Design, Setting, And Participants: A multicenter (9 US academic dermatology sites) retrospective cohort study was conducted of patients 18 years or older with moderately dysplastic nevi with positive histologic margins and 3 years or more of follow-up data collected consecutively from January 1, 1990, to August 31, 2014. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.3359DOI Listing
December 2018
17 Reads

DOCUMENTATION OF A NEW CHOROIDAL NEVUS.

Retin Cases Brief Rep 2018 Oct 3. Epub 2018 Oct 3.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.

Purpose: To describe the occurrence of an acquired choroidal nevus in a 73-year-old white man.

Methods: Case report.

Results: A 73-year-old white man was referred for an evaluation and treatment of macular changes in his left eye consistent with pachychoroid neovasculopathy. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000822DOI Listing
October 2018
14 Reads

The role of TERT promoter mutations in differentiating recurrent nevi from recurrent melanomas: A retrospective, case-control study.

J Am Acad Dermatol 2019 Mar 1;80(3):685-693. Epub 2018 Oct 1.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Background: Repigmentation at previous biopsy sites pose a significant diagnostic dilemma given clinical and histologic similarities between recurrent nevi and locally recurrent melanoma. Though common in melanoma, the role of TERT promoter mutations (TPMs) in recurrent nevi is unknown.

Objective: We investigated the role of TPMs in recurrent nevi and whether the presence of hotspot TPM distinguishes recurrent nevi from locally recurrent melanoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183264
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http://dx.doi.org/10.1016/j.jaad.2018.09.030DOI Listing
March 2019
7 Reads

Ipilimumab-associated halo-like inflammatory reactions around nevi during therapy for metastatic melanoma.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

University of Vermont Medical Center, Division of Dermatology, Burlington, Vermont.

Ipilimumab is an immune-modulating drug that is being used today for various cancers including metastatic malignant melanoma. Owing to its mechanism of action, several adverse events have been reported, including some affecting skin. In this work, we report a novel display of multiple ipilimumab-associated halo lichenoid reactions surrounding benign nevi during treatment of metastatic melanoma. Read More

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July 2018
4 Reads

A Case of Infundibulocystic Basal Cell Carcinoma Clinically Mimicking a Melanocytic Nevus Associated with Epidermal Cysts.

J Nippon Med Sch 2018 ;85(4):228-230

Department of Dermatology, Nippon Medical School.

A 52-year-old Japanese woman presented with a 1.5-cm black, glossy, flat, pediculated lump that clinically mimicked a melanocytic nevus on the left temporal side of her head. The subcutaneous tumor beneath the nodule was elastic and hard. Read More

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https://www.jstage.jst.go.jp/article/jnms/85/4/85_JNMS.2018_
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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-35DOI Listing
November 2018
9 Reads

Measurement of size of pigmented choroidal nevus: Superiority of multicolor imaging compared to conventional color fundus photography.

Indian J Ophthalmol 2018 Oct;66(10):1501-1503

Retina Services, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Choroidal nevi are benign fundus lesions that require regular follow with documentation. Conventional color fundus photography (CFP) has traditionally been used to images these lesions. Multicolor imaging (MCI) available on Spectralis spectral domain optical coherence tomography system is increasingly been tested vis-à-vis conventional CFP in various retinal diseases. Read More

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http://dx.doi.org/10.4103/ijo.IJO_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173023PMC
October 2018
5 Reads