8,334 results match your criteria Halo Nevus


Single molecule dynamics of the P granule scaffold MEG-3 in the C. elegans zygote.

Mol Biol Cell 2018 Dec 12:mbcE18060402. Epub 2018 Dec 12.

Department of Biological Sciences, Dartmouth College, Hanover NH 03755, USA.

During the asymmetric division of the C. elegans zygote, germ (P) granules are disassembled in the anterior cytoplasm and stabilized/assembled in the posterior cytoplasm, leading to their inheritance by the germline daughter cell. P granule segregation depends on MEG-3 and MEG-4, which are enriched in P granules and in the posterior cytoplasm surrounding P granules. Read More

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December 2018

A convenient and reproducible method for the synthesis of astatinated 4-[At]astato-l-phenylalanine via electrophilic desilylation.

Org Biomol Chem 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiation-Applied Biology, Takasaki Advanced Radiation Research Institute, National Institutes of Quantum and Radiological Science and Technology (QST), 1233 Watanuki, Takasaki, Gunma 370-1292, Japan.

The 211At-labeled compound, 4-[211At]astato-l-phenylalanine, is one of the most promising amino acid derivatives for use in targeted alpha therapy (TAT) for various cancers. Electrophilic demetallation of a stannyl precursor is the most widely used approach for labeling biomolecules with 211At. However, the low acid-resistance of the stannyl precursor necessitates the use of an N- and C-terminus-protected precursor, which results in a low overall radiochemical yield (RCY) due to the multiple synthetic steps involved. Read More

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December 2018
1 Read

Complete Genome Sequence of Salinisphaera sp. Strain LB1, a Moderately Halo-Acidophilic Bacterium Isolated from Lake Brown, Western Australia.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

Department of Biological Sciences, Missouri University of Science and Technology, Rolla, Missouri, USA.

Salinisphaera sp. strain LB1 was isolated from Lake Brown, Western Australia, surface water enriched at pH 4.0 and with 5% (wt/vol) NaCl. Read More

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October 2018

Thoracic spine dislocation in Gorham-Stout Syndrome: Case report and literature review.

Surg Neurol Int 2018 1;9:223. Epub 2018 Nov 1.

Spanish Hospital, Mendoza, Argentina.

Background: The Gorham-Stout syndrome (GSS), also known as phantom bone disease, is a rare bone condition of unknown etiology. Involvement of the spine is described in <50 cases in the literature. Here, we report a case of thoracic spine fracture dislocation in a young female who was known to have GSS. Read More

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November 2018

Sonographic Characteristics of Papillary Thyroid Carcinoma with Coexistent Hashimoto's Thyroiditis: Conventional Ultrasound, Acoustic Radiation Force Impulse Imaging and Contrast-Enhanced Ultrasound.

Ultrasound Med Biol 2018 Dec 8. Epub 2018 Dec 8.

Department of Ultrasound Diagnosis, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Our objective was to provide the various sonographic characteristics of papillary thyroid carcinomas for Hashimoto's thyroiditis (HT) patients, including conventional ultrasound (US), acoustic radiation force impulse Virtual Touch imaging and quantification (ARFI-VTIQ) and contrast-enhanced ultrasound (CEUS). Sixty-nine HT patients with 85 thyroid nodules (TNs) (49 malignant and 36 benign) were enrolled in this study. We evaluated the size, shape, margin, echogenicity, presence of halo, calcification, vascularity and ARFI-VTIQ and CEUS parameters for each nodule and compared the findings with the reference standards of histopathological and/or cytologic results. Read More

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December 2018
4 Reads

Gastric wall fat halo sign in patients without intestinal disease.

Clin Imaging 2018 Nov 30;54:31-36. Epub 2018 Nov 30.

Trabzon Kanuni Education and Research Hospital, Department of Radiology, 61080 Trabzon, Turkey.

Purpose: To investigate the relationship between gastric wall fat halo sign and visceral obesity with potentially associated diseases.

Materials And Methods: Between September 2015 and April 2017, 90 patients with gastric wall fat halo signs and 130 controls were prospectively evaluated. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), percentage of visceral fat (VF%) and the presence of colic or ileal fat halo signs, hepatic steatosis and aortic calcified plaques were recorded for the two groups. Read More

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November 2018
4 Reads

Pseudomonas coronafaciens sp. nov., a new phytobacterial species diverse from Pseudomonas syringae.

PLoS One 2018 6;13(12):e0208271. Epub 2018 Dec 6.

Department of Plant Pathology, Physiology and Weed Science, Tidewater Agricultural Research and Extension Center, Virginia Tech, Suffolk, VA, United States of America.

We propose Pseudomonas coronafaciens sp. nov. as a new species in genus Pseudomonas, which is diverse from P. Read More

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December 2018
1 Read

Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria.

Biomed Res Int 2018 4;2018:2780948. Epub 2018 Nov 4.

Laboratory of Microbiology Studies, Life Sciences Institute, Campus Governador Valadares, Federal University of Juiz de Fora, Rua São Paulo 745, Centro, Governador Valadares, MG, 35010180, Brazil.

Dental caries are a process of demineralization and destruction of human teeth. They originate through many factors and are associated with biofilm formation, which consists of bacteria adhered to the teeth that form a structurally and functionally organized mass called dental plaque. Both the presence of and the frequent consumption of sucrose correlate with a higher prevalence of caries in humans. Read More

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November 2018
2 Reads

An experiment to search for dark-matter interactions using sodium iodide detectors.

Authors:

Nature 2018 12 5;564(7734):83-86. Epub 2018 Dec 5.

Observations of galaxies and primordial radiation suggest that the Universe is made mostly of non-luminous dark matter. Several new types of fundamental particle have been proposed as candidates for dark matter, such as weakly interacting massive particles (WIMPs). These particles would be expected to interact with nuclei in suitable detector materials on Earth, for example, causing them to recoil. Read More

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December 2018

Well-Defined Amidate-Functionalized N-Heterocyclic Carbene -Supported Rare-Earth Metal Complexes as Catalysts for Efficient Hydroboration of Unactivated Imines and Nitriles.

Inorg Chem 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science , Anhui Normal University , Wuhu , Anhui 241002 , P. R. China.

Four amidate-functionalized N-heterocyclic carbene (NHC) rare-earth metal amido complexes [(κ-N,O-κ-L)REN(SiMe)] (L = 1-(CHC═ONCHCH)-3-(CH)CH(N(CH)NC)) [RE = Er (1), Y (2), Dy (3), Gd (4)] were synthesized by one-pot reactions of 2 equiv of (1-(CHC═ONHCHCH)-3-(CH)CH-(N(CH)NCH))Br (HLBr) with 5 equiv of KN(SiMe) followed by treatment with 1 equiv of RECl in tetrahydrofuran at -40 °C. These complexes were fully characterized, and their catalytic activities toward hydroboration of unactivated imines and nitriles were investigated, and it was found that these complexes displayed excellent activities as well as remarkable functional group compatibility for imine and nitrile substrates such as halo-, alkyl-, hydroxyl-, N, N-dimethylamino-, and nitro- substituents. Among those, the chemoselectivity for this reaction among the common unsaturated functional groups was achieved in the order C═O ≫ C═N > C≡N > COEt > C═C in the current catalytic system, which may facilitate their further application in synthetic chemistry. Read More

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December 2018

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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December 2018
1 Read

Missing Satellites Problem: Completeness Corrections to the Number of Satellite Galaxies in the Milky Way are Consistent with Cold Dark Matter Predictions.

Phys Rev Lett 2018 Nov;121(21):211302

Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, Maryland 21218, USA.

A critical challenge to the cold dark matter (CDM) paradigm is that there are fewer satellites observed around the Milky Way than found in simulations of dark matter substructure. We show that there is a match between the observed satellite counts corrected by the detection efficiency of the Sloan Digital Sky Survey (for luminosities L≳340  L_{⊙}) and the number of luminous satellites predicted by CDM, assuming an empirical relation between stellar mass and halo mass. The "missing satellites problem," cast in terms of number counts, is thus solved. Read More

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November 2018
2 Reads

Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum.

J Ethnopharmacol 2018 Dec 1;231:464-473. Epub 2018 Dec 1.

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via A. Saffi, 2, 61029 Urbino, PU, Italy. Electronic address:

Ethnopharmacological Relevance: Ganoderma lucidum (Curtis) P. Karst. (also known as Linghzhi and Reishi) is the most appreciated and revered medicinal mushroom across many Asian countries, but its properties have also attracted interest in Western countries. Read More

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December 2018

Exocyst dynamics during vesicle tethering and fusion.

Nat Commun 2018 12 3;9(1):5140. Epub 2018 Dec 3.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA.

The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear, especially in mammalian cells. Here we tagged multiple endogenous exocyst subunits with sfGFP or Halo using Cas9 gene-editing, to create single and double knock-in lines of mammary epithelial cells, and interrogated exocyst dynamics by high-speed imaging and correlation spectroscopy. Read More

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December 2018

Sensitivity, Specificity and Reliability of the Get Active Questionnaire for Identifying Children with Medically Necessary Special Considerations for Physical Activity.

Appl Physiol Nutr Metab 2018 Nov 30. Epub 2018 Nov 30.

Children's Hospital of Eastern Ontario, 27338, Ottawa, Ontario, Canada ;

Physical activity is promoted for optimal health but may carry risks for children who require medically necessary activity restrictions. The sensitivity, specificity and reliability of the Get Active Questionnaire (GAQ) for identifying children needing special considerations during physical activity was evaluated among parents of 207 children, 3 to 14 years of age (97 (47%) female, mean age of 8.4±3. Read More

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November 2018
6 Reads

Image segmentation of activated sludge phase contrast images using phase stretch transform.

Microscopy (Oxf) 2018 Nov 29. Epub 2018 Nov 29.

Department of Electrical and Computer Engineering, Tamkang University, No. 151, Yingzhuan Road, Tamsui District, New Taipei City, Taiwan R.O.C.

Activated sludge (AS) is a biological treatment process that is employed in wastewater treatment plants. Filamentous bacteria in AS plays an important role in the settling ability of the sludge. Proper settling of the sludge is essential for normal functionality of the wastewater plants, where filamentous bulking is always a persistent problem preventing sludge from settling. Read More

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November 2018

The lung and gut microbiome: what has to be taken into consideration for cystic fibrosis?

J Cyst Fibros 2018 Nov 25. Epub 2018 Nov 25.

Halo Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.

The 15th European Cystic Fibrosis Society (ECFS) Basic Science pre-conference Symposium focused on the topic of the microbiome, asking the question "The lung and gut microbiome: what has to be considered for cystic fibrosis (CF)?" This review gives an overview of the main points raised during the symposium, which dealt with the technical considerations, pathophysiology and clinical implications of the microbiome in CF. Read More

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November 2018

Electroautotrophy of Thioalkalivibrio nitratireducens.

Bioelectrochemistry 2018 Nov 16;126:48-55. Epub 2018 Nov 16.

Laboratoire d'Ecologie Microbienne de la Rhizosphère et des Environnements Extrêmes (LEMIRE), BIAM, UMR 7265, CEA-CNRS-Aix Marseille Université, CEA Cadarache, 13108 Saint Paul Lez Durance, France. Electronic address:

The electrochemical behavior and electro-autotrophy of a halo-alkaliphilic chemo-autotrophic Ectothiorhodospiraceae isolated from a soda lake, Thioalkalivibrio nitratireducens, were investigated using electrochemical methods and confocal fluorescence microscopy. The electrocatalysis of oxygen reduction was observed at -0.25 V/Ag/AgCl (-0. Read More

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November 2018
4.172 Impact Factor

Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant : and study.

Iran J Basic Med Sci 2018 Nov;21(11):1100-1108

College of Medicine, AL-Nahrain University, Medical Microbiology Department, Baghdad, Iraq.

Objectives: Phage therapy is a potential alternative treatment for infections caused by , a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas such as Iraq.

Materials And Methods: Bacteriophages were isolated to highly resistant isolates of to form therapeutic phage cocktail, and to extract and evaluate native endolysin activity. Bacterial samples were collected in Al-Imamein Al-kadhimein Medical City Hospital. Read More

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November 2018

[Contrastive analysis of ultrasonographic features of synchronous and heterochronic liver metastasis in patients with stromal tumor].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):829-832

Department of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin's Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for cancer, Tianjin 300060, China.

To investigate the ultrasonographic features of synchronous and heterochronic liver metastasis in patients with stromal tumors, and to elucidate the value of ultrasonic examination in follow-up surgery. A total of 1 516 patients with pathologically confirmed gastrointestinal stromal tumors (GISTs) and extra-gastrointestinal stromal tumors (EGISTs) were enrolled. The ultrasonographic features of primary lesions and liver metastases in a total of 46 cases with 95 liver metastases were analyzed. Read More

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November 2018
1 Read

Ultrastructural visualization of Orientia tsutsugamushi in biopsied eschars and monocytes from scrub typhus patients in South Korea.

Sci Rep 2018 Nov 26;8(1):17373. Epub 2018 Nov 26.

Drug & Disease Target Team, Korea Basic Science Institute, Cheongju, 28119, South Korea.

Scrub typhus, which is caused by Orientia tsutsugamushi, is a public health problem in the Asian-Pacific region and is the third most frequently reported infectious disease in South Korea. While ultrastructural studies have been performed on O. tsutsugamushi in murine fibroblasts, its variable locations in patients have hampered similar studies in humans. Read More

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November 2018
1 Read

Use of Magnetic Spinal Growth Rods (MCGR) With and Without Preoperative Halo-gravity Traction (HGT) for the Treatment of Severe Early-onset Scoliosis (EOS).

J Pediatr Orthop 2018 Nov 20. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, Shriner's Hospital for Children, Portland, OR.

Background: Correction of severe scoliosis through distraction-based techniques poses a challenge. Magnetically controlled growing rod (MCGR) hardware complications are common with a 27.8% to 46. Read More

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November 2018
2 Reads

Droplet Crystal Ground States of a Dipolar Bose Gas.

Phys Rev Lett 2018 Nov;121(19):195301

The Dodd-Walls Centre for Photonic and Quantum Technologies, University of Otago, Dunedin 9016, New Zealand and Department of Physics, University of Otago, Dunedin 9016, New Zealand.

We show that the ground state of a dipolar Bose gas in a cylindrically symmetric harmonic trap has a rich phase diagram, including droplet crystal states in which a set of droplets arrange into a lattice pattern that breaks the rotational symmetry. An analytic model for small droplet crystals is developed and used to obtain a zero temperature phase diagram that is numerically validated. We show that in certain regimes a coherent low-density halo surrounds the droplet crystal, giving rise to a novel phase with localized and extended features. Read More

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November 2018

Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions.

Br J Ophthalmol 2018 Nov 22. Epub 2018 Nov 22.

Centre Ophtalmologique de l'Odeon, Paris, France.

Aims: To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity.

Methods: Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. Read More

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November 2018
8 Reads

Citrus peels prevent cancer.

Phytomedicine 2018 Nov 17;50:231-237. Epub 2017 Aug 17.

Phytochemistry and Phytopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Pacha-Palode 695 562 Thiruvananthapuram, Kerala, India. Electronic address:

Background: Citrus comprises the largest fruit sector worldwide, and its fruit peels are the dominant 'residue' of the industry. Though not profitable, Citrus peels are industrially used for making some byproducts (cattle feed, molasses, ethanol, fiber) and for the extraction of bioactives (flavonoids, essential oils, d-limonene). Still huge amounts of peels are wasted by Citrus industries, juice and other vending sectors. Read More

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November 2018

Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans.

Org Biomol Chem 2018 Dec;16(47):9204-9210

College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China.

The first example of the direct halosulfenylation of benzo[b]furans with commercially available disulfides and N-halosuccinimides has been achieved, providing an efficient metal-free synthetic pathway to access diverse 3-halo-2-thiobenzo[b]furans in moderate to excellent yields. In particular, a halogen (e.g. Read More

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December 2018

Halo in the box: a macroscopic crystal arrangement to project mosaic halos.

Appl Opt 2018 Oct;57(29):8614-8623

We describe a three-dimensional halo demonstration experiment. A volumetric arrangement of crystals is used to project a mosaic halo display upon illumination. The demonstration can be used to convey the collective scattering aspect of the natural halo mechanism and at the same time vividly portray the concept of orientation classes in the context of halo theory. Read More

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October 2018

Endoscopic Endonasal Resection of the Odontoid Process in a Patient with Chronic Injury of the C1 Transverse Ligament.

Asian J Neurosurg 2018 Oct-Dec;13(4):1179-1181

Department of Neurosurgery, Sklifosovsky Research Institute of Emergency Care, Moscow, Russia.

Atlas dislocation after transverse ligament injury is one of the most rare types of trauma to the upper cervical level. If magnetic resonance imaging of the craniovertebral junction reveals the Kassam line passing through the cervix of the odontoid process, a transnasal approach can be used for surgical treatment. Here, we present a case in which an endoscopic endonasal approach was used to treat chronic traumatic transligamentous atlas dislocation. Read More

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November 2018
5 Reads

Pd-Catalyzed Annulation of 1-Halo-8-arylnaphthalenes and Alkynes Leading to Heptagon-Embedded Aromatic Systems.

Chemistry 2018 Nov 20. Epub 2018 Nov 20.

Nanyang Technological University, Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, 21 Nanyang Link, 637371, Singapore, SINGAPORE.

A palladium-catalyzed heptagon-forming annulation reaction between 1-halo-8-arylnaphthalene and diarylacetylene is reported. The reaction is promoted using a catalytic system comprised of Pd(OAc)2, moderately electron-deficient triarylphosphine P(4-ClC6H4)3, and Ag2CO3 to afford benzo[4,5]cyclohepta[1,2,3-de]naphthalene derivatives in moderate to good yields, in preference to fluoranthene as a competing byproduct. Twofold annulation can also be achieved to access a novel heptagon-embedded polycyclic aromatic hydrocarbon compound. Read More

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November 2018
5.731 Impact Factor

Halo formations around senile hemangiomas in diffuse plane normolipemic xanthomatosis associated with monoclonal gammopathy.

JAAD Case Rep 2018 Nov 10;4(10):1034-1036. Epub 2018 Nov 10.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

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November 2018

Field-based measurement of cardiorespiratory fitness to evaluate physical activity interventions.

Bull World Health Organ 2018 Nov 12;96(11):794-796. Epub 2018 Sep 12.

Kinesiology and Public Health Education, University of North Dakota, Grand Forks, United States of America.

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November 2018

Is There a "Halo Effect" for Bariatric Surgery?

Am Surg 2018 Aug;84(8):e328-e329

Division of Minimal Access and Bariatric Surgery, Greenville Health System, Greenville, South Carolina, USA.

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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Sci Rep 2018 Nov 19;8(1):16994. Epub 2018 Nov 19.

Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their electrophysiological and secretory properties. Read More

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November 2018
3 Reads

Cucurbitacins as Anticancer Agents: A Patent Review.

Recent Pat Anticancer Drug Discov 2018 Nov 19. Epub 2018 Nov 19.

Department of Plant Sciences, Quaid-i-Azam University, Islamabad. Pakistan.

Background: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its anticancer effects.

Objective: This review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade. Read More

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November 2018
3 Reads

Bundled Payment "Creep": Institutional Redesign for Primary Arthroplasty Positively Affects Revision Arthroplasty.

J Arthroplasty 2018 Oct 29. Epub 2018 Oct 29.

Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL.

Background: Revision total joint arthroplasty (TJA) is associated with increased readmissions, complications, and expense compared to primary TJA. Bundled payment methods have been used to improve value of care in primary TJA, but little is known of their impact in revision TJA patients. The purpose of this study is to evaluate the impact of a care redesign for a bundled payment model for primary TJA on quality metrics for revision patients, despite absence of a targeted intervention for revisions. Read More

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October 2018
1 Read

Basilar impression in osteogenesis imperfecta treated with staged halo traction and posterior decompression with short-segment fusion.

J Craniovertebr Junction Spine 2018 Jul-Sep;9(3):212-215

Department of Orthopaedics, Nemours/Alfred I. Dupont Hospital for Children, Wilmington, Delaware, USA.

Basilar impression is a cranial base abnormality associated with osteogenesis imperfecta (OI) with serious neurologic implications but controversial treatment options. Combined anterior and posterior decompression with long-segment posterior fusion is often recommended. We report a patient with OI (Sillence type III) with basilar impression treated with halo traction followed by posterior surgery. Read More

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November 2018
2 Reads

Development of a Highly Active Fluorescence-Based Detector for Yeast G Protein-Coupled Receptor Ste2p.

J Microbiol Biotechnol 2018 Oct;28(10):1589-1603

School of Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea.

Twenty analogs of [Orn,D-Ala]α-factor were synthesized and assayed for their biological activities: seven analogs of [Orn,X]α-factor, seven analogs of [X,D-Ala]α-factor, five analogs of [X,X,D-Ala]α-factor, and native α-factor (X = amino acids). Their biological activities (halo, gene induction, and affinity) were measured using Y7925 and LM102 and compared with those of native α-factor (100%). G protein-coupled receptor was expressed in strain LM102 containing pESC-LEU- vector. Read More

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October 2018
3 Reads

A clinical assessment of visual performance of combining the TECNIS Symfony Extended Range of Vision IOL (ZXR00) with the +3.25 D TECNIS Multifocal 1-piece IOL (ZLB00) in subjects undergoing bilateral cataract extraction.

Authors:
Sondra Black

Clin Ophthalmol 2018 23;12:2129-2136. Epub 2018 Oct 23.

Crystal Clear Vision Canada, ON, Canada,

Purpose: To combine the increased depth of focus of the TECNIS Symfony intraocular lens (IOL) with a TECNIS Multifocal (MF) low-add IOL (+3.25) to enable a patient to be less dependent on corrective lenses.

Setting: Clinic in Canada. Read More

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October 2018

Expression of Halo-hFGF18 and study of its effect on differentiation of ATDC5 cells.

Protein Expr Purif 2018 Oct 26;155:8-14. Epub 2018 Oct 26.

College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, Zhejiang, China. Electronic address:

Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor family and important in cartilage growth and development. However, the mechanism by which FGF18 mediates its biological functions is still unclear. In our study, we expressed the rhFGF18 protein fused to a HaloTag, (Halo-rhFGF18). Read More

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October 2018
2 Reads

Diagnostic performance of temporal artery ultrasound for the diagnosis of giant cell arteritis: a systematic review and meta-analysis of the literature.

Autoimmun Rev 2018 Nov 5. Epub 2018 Nov 5.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Centre National de Référence des Maladies Systémiques Autoimmunes Rares RESO, F-67000 Strasbourg, France. Electronic address:

Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of temporal artery ultrasound for the diagnosis of GCA. For this, we searched EMBASE, MEDLINE and the Cochrane Database of Systematic Reviews without language restriction. Read More

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November 2018
10 Reads

Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles.

Biomaterials 2019 Jan 31;190-191:76-85. Epub 2018 Oct 31.

Institute for Biological Interfaces (IBG-1), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz, 76344, Eggenstein-Leopoldshafen, Germany. Electronic address:

Silica nanoparticles are widely used platform materials for the immobilization of proteins to realize applications in biomedicine and biotechnology. We here report on the use of a highly delicate protein for the systematic evaluation of routes for the surface modification of multifunctional silica nanoparticles. To investigate how surface immobilization methods affect the functionality of surface-bound proteins, we constructed a novel fusion protein, dubbed FlipHOB, that combines the glucose sensor protein FLIP with a variant of the commercially-available self-ligating Halo-tag. Read More

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January 2019
3 Reads

Structures and energetic properties of 4-halobenzamides.

Acta Crystallogr C Struct Chem 2018 11 23;74(Pt 11):1395-1402. Epub 2018 Oct 23.

Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USA.

The amide bond represents one of the most fundamental functional groups in chemistry. The properties of amides are defined by amidic resonance (n→π* conjugation), which enforces planarity of the six atoms comprising the amide bond. Despite the importance of 4-halo-substituted benzamides in organic synthesis, molecular interactions and medicinal chemistry, the effect of 4-halo-substitution on the properties of the amide bond in N,N-disubstituted benzamides has not been studied. Read More

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November 2018

Posterior open reduction and internal fixation of C1 fractures: the C-clamp technique.

Acta Neurochir (Wien) 2018 Dec 5;160(12):2451-2457. Epub 2018 Nov 5.

Department of Neurosurgery, Stanford Hospital and Clinics, Stanford University, 300 Pasteur Drive, Edwards Bldg., R-201, Stanford, CA, 94305, USA.

Background: The treatment of isolated atlas (C1) fractures is still controversial. The surgical management usually involves an arthrodesis of the atlanto-axial (C1-C2) joint with or without occipital fixation. We reviewed the senior author's series of posterior only open reduction and internal fixation (ORIF) of isolated C1 fractures. Read More

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December 2018
6 Reads

Kernel density analysis reveals a halo pattern of breast cancer incidence in Connecticut.

Spat Spatiotemporal Epidemiol 2018 Aug 19;26:143-151. Epub 2018 Jun 19.

Department of Natural Resources and Environment Management, Faculty of Management, University of Haifa, Haifa, Israel.

Breast cancer (BC) incidence rates in Connecticut are among the highest in the United States, and are unevenly distributed within the state. Our goal was to determine whether artificial light at night (ALAN) played a role. Using BC records obtained from the Connecticut Tumor Registry, we applied the double kernel density (DKD) estimator to produce a continuous relative risk surface of a disease throughout the State. Read More

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August 2018
3 Reads

A new ultrasound nomogram for differentiating benign and malignant thyroid nodules.

Clin Endocrinol (Oxf) 2018 Nov 3. Epub 2018 Nov 3.

Department of Ultrasound Imaging, Guangdong Province Hospital of Chinese Medicine, Guangdong, 510120, China.

Objective: The Thyroid Imaging Reporting and Data System (TI-RADS) is commonly used for risk stratification of thyroid nodules. However, this system has a pooled sensitivity and specificity. The aim of this study was to build a new model based on TI-RADS for evaluating ultrasound image patterns that offers improved efficacy for differentiating benign and malignant thyroid nodules. Read More

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November 2018
4 Reads

Temporal Trends in the Cardiorespiratory Fitness of 2,525,827 Adults Between 1967 and 2016: A Systematic Review.

Sports Med 2018 Nov 3. Epub 2018 Nov 3.

Department of Education, Health and Behavior Studies, University of North Dakota, 2751 2nd Avenue North, Stop 8235, Grand Forks, ND, 58202, USA.

Objective: To estimate international and national temporal trends in the cardiorespiratory fitness (CRF) of adults, and to examine relationships between trends in CRF and trends in health-related, socioeconomic, and environmental indicators.

Methods: Data were obtained from a systematic search of studies that explicitly reported temporal trends in the CRF of apparently healthy adults aged 18-59 years. Sample-weighted temporal trends were estimated using best-fitting regression models relating the year of testing to mean CRF. Read More

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November 2018

Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction.

J Am Chem Soc 2018 Nov 5;140(45):15170-15175. Epub 2018 Nov 5.

CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.

A catalytic asymmetric vinylogous Mannich-type reaction of γ-halo-α,β-unsaturated N-acylpyrazoles and N-Boc-aldimines was disclosed, which afforded an array of halogenated (F-, Cl-, and Br-) allylic stereogenic carbon centers in high yields with good to high regio-, diastereo-, and enantioselectivities. The brominated product served as a suitable electrophile for common S2 nucleophilic substitution and copper-mediated S2' allylic alkylation with metal reagents. The utility of present methodology was demonstrated by the asymmetric synthesis of a common intermediate toward the synthesis of two chiral 2,3-disubstituted piperidine pharmaceuticals. Read More

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November 2018
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The merger that led to the formation of the Milky Way's inner stellar halo and thick disk.

Nature 2018 11 31;563(7729):85-88. Epub 2018 Oct 31.

Leiden Observatory, Leiden University, Leiden, The Netherlands.

The assembly of our Galaxy can be reconstructed using the motions and chemistry of individual stars. Chemo-dynamical studies of the stellar halo near the Sun have indicated the presence of multiple components, such as streams and clumps, as well as correlations between the stars' chemical abundances and orbital parameters. Recently, analyses of two large stellar surveys revealed the presence of a well populated elemental abundance sequence, two distinct sequences in the colour-magnitude diagram and a prominent, slightly retrograde kinematic structure in the halo near the Sun, which may trace an important accretion event experienced by the Galaxy. Read More

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November 2018
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