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    Pigmented Kamino bodies: a little-known histological finding. Prevalence in 19 cases of Reed nevus.
    An Bras Dermatol 2017 May-Jun;92(3):379-382
    Laboratory of Medical Investigation in Mycologia, Faculdade de Medicina, Universidade de São Paulo (LIM 53, FMUSP), São Paulo, SP, Brazil.
    The present study aimed to determine the prevalence of Kamino bodies in Reed nevus, since most studies to date show conflicting data on this issue. This was a retrospective observational study, in which the histopathology of 19 Reed nevus lesions were reviewed. The slides were stained by hematoxylin and eosin and periodic acid-Schiff, with a special focus placed on the identification of Kamino bodies. Read More

    Non-melanoma Hutchinson's sign: A reappraisal of this important, remarkable melanoma simulant.
    J Eur Acad Dermatol Venereol 2017 Nov 24. Epub 2017 Nov 24.
    Dermatology, Centre Hospitalier Lyon Sud, 69495, Pierre Benite, Cedex, France.
    Background: More than 20 years ago our reappraisal of the Hutchinson Sign (HS) gave birth to the concept of the Pseudo-Hutchinson sign.

    Objectives: We have found it interesting to emphasize some important histologic points and to expand the list of the numerous HS simulants.

    Methods: We have examined the cutaneous samples taken from the pigmented skin of patients in association with nail matrix biopsy. Read More

    Evaluating melanocytic lesions with single nucleotide polymorphism (SNP) chromosomal microarray.
    Exp Mol Pathol 2017 Dec 21;103(3):279-287. Epub 2017 Nov 21.
    Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States. Electronic address:
    Histopathology is the gold standard for diagnosing melanocytic lesions; however, distinguishing benign versus malignant is not always clear histologically. Single nucleotide polymorphism (SNP) microarray analysis may help in making a definitive diagnosis. Here, we share our experience with the Oncoscan FFPE Assay and demonstrate its diagnostic utility in the context of ambiguous melanocytic lesions. Read More

    Nevi and lasers: Practical considerations.
    Lasers Surg Med 2017 Nov 21. Epub 2017 Nov 21.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Lasers are increasingly used for elective ablation of melanocytic nevi (MN). However, the associated risks of treating MN with lasers are debated and not well studied. Theoretical risks include inadvertently treating a melanoma mistaken for a nevus, the inability to remove all nevus cells and the possibility for residual cells to undergo malignant transformation, and the difficulty in clinically monitoring the remnant nevus for melanoma progression. Read More

    Pigmented Spindle Cell Nevus of Reed of the Eyelid.
    Ocul Oncol Pathol 2017 Sep 27;3(3):176-180. Epub 2017 Jan 27.
    Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.
    Purpose: To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid.

    Methods: The findings of clinical and histopathological examination are presented, along with differential diagnoses and a review of the pertinent literature.

    Case: A 3-year-old boy presented with a rapidly growing, heavily pigmented left lower lid papule raising the concern of malignancy, warranting excisional biopsy. Read More

    Factors Associated with Development of Vitiligo in Patients with Halo Nevus.
    Chin Med J (Engl) 2017 Nov;130(22):2703-2708
    Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
    Background: Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.

    Methods: We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital of Sun Yat-sen University between January 2011 and December 2016. Read More

    Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids.
    Indian J Ophthalmol 2017 Nov;65(11):1219-1221
    Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. Read More

    Eccrine-Centric Melanocytic Nevus.
    Am J Dermatopathol 2017 Oct 27. Epub 2017 Oct 27.
    *Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL; †Metropolitan Dermatologic Surgery, Atlanta, GA; ‡Pathology and Laboratory Medicine Service, James A. Haley VA Hospital, Tampa, FL; §Georgia Dermatopathology, Savannah, GA; and ¶Department of Dermatology, University of Florida, Gainesville, FL.
    Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. Read More

    Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.
    PLoS One 2017 1;12(11):e0186958. Epub 2017 Nov 1.
    Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
    We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Read More

    Serial Tissue Expansion at the Same Site in Pediatric Patients: Is the Subsequent Expansion Faster?
    Arch Plast Surg 2017 Nov 26;44(6):523-529. Epub 2017 Oct 26.
    Department of Plastic and Reconstructive Surgery, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Korea.
    Background: Serial tissue expansion is performed to remove giant congenital melanocytic nevi. However, there have been no studies comparing the expansion rate between the subsequent and preceding expansions. In this study, we analyzed the rate of expansion in accordance with the number of surgeries, expander location, expander size, and sex. Read More

    Classifying dermoscopic patterns of naevi in a case-control study of melanoma.
    PLoS One 2017 17;12(10):e0186647. Epub 2017 Oct 17.
    Dermatology Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
    Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied two systems to a case-control study of melanoma with 1037 participants: 573 classified using a "1/3 major feature" system, 464 classified based on rules of appearance, and 263 classified with both criteria. There was strong correlation for non-specific (Spearman R = 0. Read More

    Clinical and dermoscopic characterization of pediatric and childhood melanomas. Multicenter study of 52 cases.
    J Am Acad Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:
    Background: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse and this may in part contribute to delay in detection and thicker tumors.

    Objective: to analyze the clinical-dermoscopic characteristics of PM.

    Methods: retrospective study of 52 melanomas diagnosed before age of 20. Read More

    Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus.
    Med J Aust 2017 Oct;207(8):333-338
    Victorian Melanoma Service, Alfred Hospital, Melbourne, VIC.
    Objectives: To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics.

    Design, Setting And Participants: Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne.

    Methods And Main Outcome Measures: Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses. Read More

    The recurrent nevus phenomenon.
    An Bras Dermatol 2017 Jul-Aug;92(4):531-533
    Department of Clinical Medicine, Universidade Federal de Santa Maria (UFSM) - Santa Maria (RS), Brazil.
    Recurrent melanocytic nevus is a proliferation of melanocytes arising from a melanocytic nevus removed partially. Asymmetry and irregular pigmentation may lead to misdiagnosis of melanoma. We report a patient presented with a lesion on the lower abdomen, which was removed by shave excision. Read More

    Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.
    Nat Commun 2017 09 21;8(1):644. Epub 2017 Sep 21.
    Department of Biopathology, Centre Léon Bérard, Lyon, 69008, France.
    Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathways as characteristic of DPN. Read More

    Pigmented Trichoblastoma of Nose: An Unusual Occurrence.
    J Clin Diagn Res 2017 Jul 1;11(7):MD09-MD10. Epub 2017 Jul 1.
    Junior Resident, Department of Ear, Nose and Throat, Sri Siddhartha Medical College, Agalakote, Karnataka, India.
    Nevus sebaceus of Jadassohn is a congenital tumour affecting the scalp and face. It is usually presented as a pigmented patch or plaque. It is a complex cutaneous hamartoma which involves pilosebaceous follicle, epidermis and adnexal structures. Read More

    Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions.
    Ocul Oncol Pathol 2017 Jul 14;3(2):142-148. Epub 2016 Dec 14.
    UCLA Stein Eye Institute, Los Angeles, CA, USA.
    Aims: The aim of this paper was to compare the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions.

    Methods: We analyzed the spectral-domain optical coherence tomography (SD-OCT) features of 9 eyes with optic disc melanocytoma and compared them with those of choroidal melanoma and nevus.

    Results And Conclusion: We identified 2 categories of SD-OCT findings in optic disc melanocytoma: (a) type 1, the typical, prominent, hyperpigmented lesion with SD-OCT findings of a hyperreflective, disorganized overlying retina and a posterior hyporeflective shadow, and (b) the less common, atypical, minimally pigmented type 2 lesion overlaid by a relatively well-organized retina that lacks a posterior hyporeflective shadow. Read More

    Pediatric conjunctival melanoma arising from a compound nevus.
    J AAPOS 2017 Oct 30;21(5):416-418. Epub 2017 Aug 30.
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina. Electronic address:
    We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with fine surrounding vessels. Enhanced depth imaging-optical coherence tomography showed no invasion into the sclera. Read More

    [Analysis of clinicopathologic characteristics of 422 conjunctival melanocytic nevi specimens].
    Zhonghua Yan Ke Za Zhi 2017 Aug;53(8):583-587
    Beijing Institute of Ophthalmology, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology&visual sciences key lab., Beijing 100005, China.
    Objective: To describe the clinicopathologic characteristics of 422 conjunctival melanocytic nevi and detect the incidence of malignancy in those patients. Methods: Retrospective case series study. A retrospective study was conducted by reviewing 422 conjunctival melanocytic nevi specimens obtained at Beijing Tongren Eye Center from June, 2004 to May, 2016. Read More

    Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families.
    J Invest Dermatol 2017 Dec 19;137(12):2606-2612. Epub 2017 Aug 19.
    Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. Electronic address:
    Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage and 2-mm, 5-mm, and atypical nevus counts among blood-related members of melanoma families. Read More

    Blue rubber bleb nevus syndrome: our experience and new endoscopic management.
    Medicine (Baltimore) 2017 Aug;96(33):e7792
    aDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province bDepartment of Nephrology, Jilin City Central Hospital, Jilin, Jilin Province, China.
    The aim of our study is to enhance the awareness of blue rubber bleb nevus syndrome (BRBNS) through the patients in our hospital and introduced a new measure of endoscopic intervention.A retrospective review of 5 patients, who were diagnosed as BRBNS in our hospital from January 2013 to January 2017, was conducted. Data were collected with regard to demographics, clinical presentation, endoscopic and imaging findings, management, and follow-up data. Read More

    Alkaptonuria: A Case Report With Diagnostic Challenge.
    S D Med 2017 Aug;70(8):366-368
    Department of Dermatology, University of South Dakota Sanford School of Medicine.
    Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Read More

    Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus.
    Int J Mol Sci 2017 Aug 15;18(8). Epub 2017 Aug 15.
    Departments of Dermatology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35201, USA.
    Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Read More

    Toward a Molecular-Genetic Classification of Spitzoid Neoplasms.
    Clin Lab Med 2017 Sep;37(3):431-448
    Section of Dermatopathology, Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA.
    The histopathologic spectrum of Spitzoid neoplasms includes Spitz nevi, atypical Spitz tumors, and Spitzoid melanomas. Advances in molecular genetics have evolved to the point that Spitzoid lesions can now be reasonably classified according to their distinctive molecular-genetic alterations: Spitzoid lesions with (1) 11p amplification and/or HRAS mutations; (2) isolated loss of 6q23 by fluorescence in situ hybridization (FISH); (3) homozygous deletion of 9p21 by FISH; (4) BAP1 loss and BRAFV600 E mutation; (5) translocations involving any of a number of different oncogenic kinase drivers, including ROS1, ALK, NTRK1, NTRK3, MET, BRAF, and RET; and (6) TERT promoter mutations. Read More

    Blue Nevi and Related Tumors.
    Clin Lab Med 2017 Sep 4;37(3):401-415. Epub 2017 Jul 4.
    Lahey Clinic, 41 Mall Road, Burlington, MA 018056, USA; www.DermatopathologyConsultations.com, C/O Harvard Vanguard Medical Associates Laboratories, 152 2nd Avenue, Needhan, MA 02494, USA. Electronic address:
    The major entities related to blue nevus are common blue nevus, cellular blue nevus, atypical blue nevus, and malignant blue nevus. These lesions share presence of dermal pigmented dendritic melanocytes derived from embryonal precursors to melanocytes, Schwann cells, and glial cells migrating to the skin from the ventral neural crest. Genetically, blue nevi harbor mutations in G-protein-coupled receptor subunits GNAQ and GNA11. Read More

    Cellular Blue Nevus of Perilimbal Conjunctiva: A Case Report and Review of Literature.
    Ann Clin Lab Sci 2017 Aug;47(4):477-480
    Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin China.
    Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Read More

    Punch 'scoring': a technique that facilitates melanoma diagnosis of clinically suspicious pigmented lesions.
    Histopathology 2017 Aug 10. Epub 2017 Aug 10.
    Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
    Aims: Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. Read More

    Single-Stage Reconstruction of Eyebrow Defect Using a V-Y Advancement Pedicle Flap Based on the Orbicularis Oculi Muscle.
    J Craniofac Surg 2017 Sep;28(6):e521-e522
    Department of Plastic and Reconstructive Surgery, The First Bethune Hospital of Jilin University, Changchun, China.
    Eyebrows play an important role in face expression and facial mimics by virtue of muscle contraction. Defects or deformity of the eyebrows result in abnormal facial expressions, and may lead to aesthetic issues for patients. The objective of this study is to report the case of a patient, with a congenital skin pigmented nevus at the right side of the eyebrow treated with direct surgical resection and followed by immediate reconstruction of the eyebrow with a V-Y advancement pedicle flap based on the orbicularis oculi muscle. Read More

    Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes.
    Am J Surg Pathol 2017 Oct;41(10):1333-1346
    Departments of *Pathology §Dermatopathology ∥Dermatology †Clinical Cancer Genomics Laboratory ‡Helen Diller Cancer Center, University of California, San Francisco, CA ¶Department of Pathology, Lahey Clinic, Burlington, MA.
    Pigmented epithelioid melanocytoma (PEM) is a rare cutaneous melanocytic tumor first described as epithelioid blue nevus in patients with the Carney Complex (CC). PEM was among the first established examples of an intermediate class of melanocytic tumors, including atypical Spitz tumors, with frequent metastasis to lymph nodes but only rare extranodal spread. Sporadic and CC-associated PEM are essentially histologically indistinguishable. Read More

    Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy?
    Open Access Maced J Med Sci 2017 Jul 22;5(4):549-550. Epub 2017 Jul 22.
    Department of Dermatology and Venereology, Medical University of Plovdiv, 15A Vasil Aprilov blvd., 4002 Plovdiv, Bulgaria.
    We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks. A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Read More

    A single-institution assessment of superficial spreading melanoma (SSM) in the pediatric population: Molecular and histopathologic features compared with adult SSM.
    J Am Acad Dermatol 2017 Nov 25;77(5):886-892. Epub 2017 Jul 25.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois. Electronic address:
    Background: The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups.

    Objective: In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superficial spreading melanoma (SSM) in prepubertal and adolescent patients to that in adults. Read More

    Retinal pigment epithelium adenoma in vitreous fluid cytology.
    Diagn Cytopathol 2017 Dec 18;45(12):1128-1131. Epub 2017 Jul 18.
    Department of Pathology, University of Michigan Hospital and Health System, Ann Arbor, Michigan.
    Ocular cytology specimens are relatively uncommon, adding to the difficulty of their evaluation by cytopathologists. While melanomas account for a majority of primary intraocular pigmented lesions, other diagnostic considerations must be included in the differential. This brief report highlights a case of a pigmented ocular lesion in a 24-year-old man and key morphologic, immunohistochemical, and clinical differences between melanoma, melanocytoma, choroidal nevus, and retinal pigment epithelium (RPE) adenoma. Read More

    Iris Freckles a Potential Biomarker for Chronic Sun Damage.
    Invest Ophthalmol Vis Sci 2017 May;58(6):BIO174-BIO179
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Purpose: To investigate the role of sunlight exposure in iris freckles formation.

    Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Read More

    Hard to face: cutaneous malignant melanoma.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):53-55
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    An 88-year-old Caucasian man recently sought medical attention due to recrudescence of skin disease in the area of previously excised nodule (in 2002) on the nose dorsum. The original lesion was clinically considered as a pigmented basal cell carcinoma, after which histological examination revealed a superficial spreading melanoma in vertical growth face (Clark level IV; Breslow thickness 2.1 mm) arising from a pre-existing nevus. Read More

    Anatomic mapping and clinicopathologic analysis of benign acral melanocytic neoplasms: A comparison between adults and children.
    J Am Acad Dermatol 2017 Oct 1;77(4):735-745. Epub 2017 Jul 1.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. Electronic address:
    Background: The clinicopathologic features of benign acral melanocytic neoplasms (BAMNs) remain poorly understood.

    Objective: To define the clinicopathologic features of BAMNs.

    Methods: We analyzed clinical data and mapped BAMNs anatomically. Read More

    Pathologists' diagnosis of invasive melanoma and melanocytic proliferations: observer accuracy and reproducibility study.
    BMJ 2017 Jun 28;357:j2813. Epub 2017 Jun 28.
    Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
    Objective To quantify the accuracy and reproducibility of pathologists' diagnoses of melanocytic skin lesions.Design Observer accuracy and reproducibility study.Setting 10 US states. Read More

    The correlation of the standard 5 probe FISH assay with melanocytic tumors of uncertain malignant potential.
    Ann Diagn Pathol 2017 Jun 10;28:30-36. Epub 2016 Nov 10.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:
    Background: FISH has recently emerged as a technique to better assess the malignant potential of histologically ambiguous melanocytic lesions. However, the usefulness of FISH has not been conclusively established. The purpose of this study was to further explore the diagnostic value of FISH in distinguishing the borderline melanocytic tumor (BMT) from melanoma. Read More

    Melanocytic nevi and melanoma: unraveling a complex relationship.
    Oncogene 2017 Oct 12;36(42):5771-5792. Epub 2017 Jun 12.
    Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
    Approximately 33% of melanomas are derived directly from benign, melanocytic nevi. Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAFV600E-activating mutations, will never progress to melanoma. Herein, we synthesize basic scientific insights and data from mouse models with common observations from clinical practice to comprehensively review melanocytic nevus biology. Read More

    Comparisons of choroidal nevus measurements obtained using 10- and 20-MHz ultrasound and spectral domain optical coherence tomography.
    Arq Bras Oftalmol 2017 Mar-Apr;80(2):78-83
    Department of Ophthalmology, Universidade Federal de São Paulo, SP, Brazil.
    Purpose:: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US).

    Methods:: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results). Anteroposterior (AP) and transverse (T) US sections corresponded to sections adjusted perpendicularly on SD-OCT. Read More

    Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma.
    Case Rep Dermatol Med 2017 8;2017:3509146. Epub 2017 May 8.
    Department of Dermatology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.
    Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Read More

    Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver.
    Pathol Res Pract 2017 Jul 30;213(7):860-862. Epub 2017 Mar 30.
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.
    A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. Read More

    Giant congenital melanocytic nevi: 40 years of experience with the serial excision technique.
    An Bras Dermatol 2017 Mar-Apr;92(2):256-259
    School of Medicine at Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Read More

    Proliferative nodule in melanocytic nevi mimicking deep penetrating nevus.
    An Bras Dermatol 2017 Mar-Apr;92(2):231-233
    Department of Dermatology, San Cecilio University Hospital - Granada, Spain.
    Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. Read More

    A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma.
    An Bras Dermatol 2017 Mar-Apr;92(2):200-205
    Dermatology Unity - Hospital das Clinicas - Universidade Federal de Minas Gerais (UFMG) - Belo Horizonte (MG), Brazil.
    Background:: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial.

    Objective:: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. Read More

    Longitudinal melanonychia in childhood: a clinical and histopathological review of Korean patients.
    Eur J Dermatol 2017 Jun;27(3):275-280
    Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
    Longitudinal melanonychia is not frequently observed in children, and few studies exist on longitudinal melanonychia in paediatric patients, especially in Asian populations. We aimed to evaluate the clinical and histological findings of longitudinal melanonychia in Korean paediatric patients. A retrospective review of paediatric patients (≤18 years old) with longitudinal melanonychia who underwent nail biopsy between January 2010 and October 2015 was performed. Read More

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