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    Atypical cellular blue nevus or malignant blue nevus?
    An Bras Dermatol 2017 Jan-Feb;92(1):110-112
    Division of Dermatology, Internal Medicine Department - Medical School of Ribeirão Preto - Universidade de São Paulo- Ribeirão Preto (SP) -Brazil.
    Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progressive growth in the last two years. Read More

    Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes.
    Curr Opin Ophthalmol 2017 Jan 30. Epub 2017 Jan 30.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.

    Recent Findings: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. Read More

    Polypoid Spitz Nevus With a Halo Reaction.
    Am J Dermatopathol 2017 Feb;39(2):130-133
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;†Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Mexico City, Mexico; and‡Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense, I+12, Madrid, Spain.
    Approximately, 2% of Spitz nevi are polypoid; between 3.6% and 7.4% present with a halo reaction. Read More

    CLINICAL PROFILE AND TRIGGERING FACTORS FOR ACQUIRED, BILATERAL NEVUS OF OTA-LIKE MACULES.
    Cutan Ocul Toxicol 2017 Jan 25:1-14. Epub 2017 Jan 25.
    a Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , China.
    BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. Read More

    Case Report of a Large Pigmented Epithelioid Melanocytoma With Suspected Lymph Node Metastases.
    Eplasty 2016 16;16:e33. Epub 2016 Dec 16.
    Departments of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objective: Pigmented epithelioid melanocytoma was proposed by Zembowicz et al in 2004 including lesions previously diagnosed as human animal-type melanoma and epithelioid blue nevus. Tumors are composed of epithelioid and spindled melanocytes with heavy pigmentation. Methods: We report a case of pigmented epithelioid melanocytoma in 47-year-old Asian woman. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms.
    J Cutan Pathol 2017 Mar 6;44(3):249-255. Epub 2017 Feb 6.
    Program in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms.

    Methods: 5-hmC IHC was performed on 54 heavily pigmented melanocytic tumors. Read More

    IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations.
    J Immunol 2017 Jan 21;198(2):950-961. Epub 2016 Dec 21.
    Department of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294; and
    In animal models, IL-12 and IL-23 participate in the development of malignant neoplasms of keratinocytes. However, the role of these cytokines in pigmented lesion development and their progression to melanoma has received little attention. IL-12p35, IL-23p19, and IL-12/IL-23p40 knockout mice on a C3H/HeN background, subjected to a melanomagenesis protocol, demonstrated profound differences in susceptibility to nevus initiation, transformation, tumorigenicity, and metastatic potential. Read More

    Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
    Semin Diagn Pathol 2016 Nov 29. Epub 2016 Nov 29.
    From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.
    This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

    Combination therapy in skin of color including injectables, laser, and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):211-217
    Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California, USA.
    With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Read More

    Pigmented oral compound nevus of retromolar area - A rare case report.
    Singapore Dent J 2016 Dec;37:33-35
    Department of Oral Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi. Electronic address:
    Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5. Read More

    Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition.
    Am J Dermatopathol 2016 Dec;38(12):e159-e162
    *Department of Anatomical Pathology, PathWest, QEII Medical Centre, Perth, Western Australia, Australia; †School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia; ‡Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia; §School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; and ¶Margaret River Surgery, Margaret River, Western Australia, Australia.
    Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. Read More

    Melanocytic Nevi of Special Sites.
    Am J Dermatopathol 2016 Dec;38(12):867-881
    *Resident, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC; †Dermatologist, International Dermatopathology Fellow, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC; and ‡Professor of Pathology and Dermatology, Director of Dermatopathology, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC.
    Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Read More

    BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION ASSOCIATED WITH RENAL CANCER: THE IMPORTANCE OF INDOCYANINE GREEN ANGIOGRAPHY AND EARLY DIAGNOSIS.
    Retin Cases Brief Rep 2016 Nov 17. Epub 2016 Nov 17.
    *Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; †Department of Ophthalmology, Brazilian Institute of Fight Against Blindness, Assis and Presidente Prudente, São Paulo, Brazil; and ‡Department of Oncology, Hospital Fundação Amaral Carvalho, Jaú, São Paulo, Brazil.
    Purpose: To report a case of bilateral diffuse uveal melanocytic proliferation associated with renal carcinoma and to illustrate the importance of ancillary examinations to early diagnosis and treatment.

    Design: Clinical case report.

    Methods: A 56-year-old man reported a 3-day history of visual impairment and scotoma in the right eye. Read More

    Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood.
    J Dtsch Dermatol Ges 2017 Jan 10;15(1):70-75. Epub 2016 Nov 10.
    Dermatology, Department of -Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
    Background And Objectives: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups.

    Patients And Methods: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome. Read More

    Flat choroidal melanoma masquerading as central serous chorioretinopathy.
    Oman J Ophthalmol 2016 Sep-Dec;9(3):174-176
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
    There are several mimickers of choroidal melanoma. We report a patient with recent family stress who developed blurred vision to 20/50 OD and was found to have unilateral central serous chorioretinopathy and a coincidental choroidal nevus. After 1 year without resolution of the subretinal fluid, the patient was referred for our opinion. Read More

    Evaluating the Causes of Freckle and Nevus from the Viewpoint of Iranian Traditional Medicine.
    Iran J Med Sci 2016 May;41(3 Suppl):S67
    Department of Iranian Traditional Medicine' School of Medicine' Shiraz University of Medical Sciences' Shiraz' Iran.
    Background: Freckles are due to an increase in the amount of dark pigments called melanin. These spots are more likely developed on the sun-exposed skin areas like the cheeks, nose, and forehead. Nevus is usually a benign melanocytic tumor and can be congenital or acquired. Read More

    Dysplastic nevi with severe atypia: Long-term outcomes in patients with and without re-excision.
    J Am Acad Dermatol 2017 Feb 9;76(2):244-249. Epub 2016 Nov 9.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:
    Background: Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited.

    Objective: We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise. Read More

    Agminated blue nevus - Case report.
    An Bras Dermatol 2016 Sep-Oct;91(5):658-660
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Blue nevi are benign melanocytic lesions located in the deeper reticular dermis, consequence of failure of melanocytic migration into the dermal-epidermal junction from the neural crest. Lesions are usually asymptomatic and solitary, but may present in a multiple or agminated (grouped) pattern. The agminated subtype is formed when bluish-pigmented lesions cluster together in a well-defined area. Read More

    Total reconstruction of giant congenital circumferential nevi of the upper limb using a large pedicle expanded flank flap: A brief report.
    Ann R Coll Surg Engl 2016 Nov 22;98(8):e150-e151. Epub 2016 Sep 22.
    Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , UK.
    Tissue expansion is an invaluable reconstructive strategy after surgical excision of a congenital naevus. However, reducing the number of operations is very important for patients with a giant congenital naevus. We used a large pedicle expanded flank flap to successfully treat a giant circumferential naevus that extended from the left upper arm to the wrist, which also provided excellent contour and colour match. Read More

    Sclerotic Regressing Large Congenital Nevus.
    Pediatr Dermatol 2016 Nov 25;33(6):e366-e367. Epub 2016 Oct 25.
    Second Department of Dermatology, Faculty of Medicine, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
    Regression of congenital nevi is usually associated with loss of pigment or halo formation. In rare cases, regression is characterized by sclerosis and hair loss. We describe a rare case of a sclerotic hypopigmented large congenital melanocytic nevus in which a localized scleroderma-like reaction process of regression seemed to have started in utero and progressed throughout early childhood. Read More

    Computer Based Melanocytic and Nevus Image Enhancement and Segmentation.
    Biomed Res Int 2016 28;2016:2082589. Epub 2016 Sep 28.
    Department of Computer Engineering, Bahria University, Islamabad, Pakistan.
    Digital dermoscopy aids dermatologists in monitoring potentially cancerous skin lesions. Melanoma is the 5th common form of skin cancer that is rare but the most dangerous. Melanoma is curable if it is detected at an early stage. Read More

    [Nested melanoma].
    Ann Dermatol Venereol 2017 Jan 19;144(1):60-64. Epub 2016 Oct 19.
    Cabinet d'anatomopathologie, SCM DMS, 23, boulevard Président-Franklin-Roosevelt, 33400 Talence, France.
    Background: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype.

    Case Report: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour. Read More

    Basal Cell Carcinoma of the Umbilicus: A Comprehensive Literature Review.
    Cureus 2016 Sep 7;8(9):e770. Epub 2016 Sep 7.
    Department of Dermatology, University of California, San Diego.
    Basal cell carcinoma (BCC) typically occurs in sun-exposed sites. Only 16 individuals with umbilical BCC have been described in the literature, and the characteristics of patients with umbilical BCC are summarized. PubMed was used to search the following terms: abdomen, basal cell carcinoma, basal cell nevus syndrome, and umbilicus. Read More

    Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review.
    Laser Ther 2016 Jun;25(2):99-104
    Department of Plastic and Reconstructive Surgery, Keio University.
    Background and aims: Recently novel picosecond duration lasers (ps-lasers) have been developed for the treatment of multicolored and recalcitrant tattoos, and safety and efficacy have been reported. We therefore hypothesized that the ps-laser could be an alternative treatment for dermal pigmented lesions and performed a retrospective review to evaluate the efficacy and safety of the ps-laser. Subjects and methods: A retrospective photographic review of 10 patients with dermal pigmented lesions was performed (ages from 4 months to 52 yr), 6 nevus of Ota, 3 ectopic Mongolian spots and 1 Mongolian spots. Read More

    [Congenital "kissing" lesions: Nevus or "café au lait" spot?]
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):433-437. Epub 2016 Oct 4.
    Service de chirurgie maxillo-faciale et plastique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Centre de référence des malformations faciales et de la cavité buccale, MAFACE, AP-HP, 75015 Paris, France; Université Paris Descartes, 75005 Paris, France. Electronic address:
    Introduction: "Café au lait" spots (CLS) are pigmented skin lesions principally located at the trunk and the limbs. Histologically, CLSs consist in an excessive pigmentation of the epidermis, with no risk of malignant transformation. The "kissing" nevus is a rare pigmented congenital nevus affecting both lower and upper eyelids in a mirror layout. Read More

    Paired comparison of the sensitivity and specificity of multispectral digital skin lesion analysis and reflectance confocal microscopy in the detection of melanoma in vivo: A cross-sectional study.
    J Am Acad Dermatol 2016 Dec 29;75(6):1187-1192.e2. Epub 2016 Sep 29.
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.
    Background: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM.

    Objective: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients). Read More

    Glowing in the Dark: Use of Confocal Microscopy in Dark Pigmented Lesions.
    Dermatol Clin 2016 Oct;34(4):431-442
    Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Villarroel 170, Barcelona 08036, Spain; CIBER de Enfermedades Raras, Barcelona, Spain.
    Reflectance confocal microscopy patterns and structures of clinically dark lesions are described. Because many of the dark lesions have melanin in superficial skin layers these lesions show great semiology by confocal. Limitations and pitfalls of reflectance confocal microscopy in clinically dark lesions are also detailed. Read More

    Agminated melanocytic nevus status post dabrafenib therapy for metastatic melanoma.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Dermatology, Complejo Hospitalario de Navarra. Pamplona, Navarra, Spain..
    Agminated melanocytic nevus is an uncommon type of mole, characterized by a local group of macular or papular pigmented lesions, well demarcated, without a common pigmented background. This pattern has also been associated with Spitz nevi, dysplastic melanocytic nevi, and non-melanocytic lesions.We describe the onset of an acquired agminated melanocytic nevus after dabrafenib treatment. Read More

    Melanocytic Nevus of the Tarsal Conjunctiva.
    Balkan Med J 2016 Jul 1;33(4):477-9. Epub 2016 Jul 1.
    Bursa Pathology Center, Bursa, Turkey.
    Background: Melanocytic nevus is a rare occurrence in the tarsal conjunctiva and only 7 well-described cases have been reported previously in the English literature.

    Case Report: The medical records of 4 patients with tarsal conjunctival melanocytic nevus were reviewed, together with the relevant literature. All patients (3 women and 1 man; age range: 17 - 40 years) had been referred with a suspicion of melanoma. Read More

    Expression of microphthalmia transcription factor, S100 protein, and HMB-45 in malignant melanoma and pigmented nevi.
    Biomed Rep 2016 Sep 1;5(3):327-331. Epub 2016 Aug 1.
    Department of Dermatology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
    Malignant melanoma (MM) is a type of malignant tumor, which originates from neural crest melanocytes. MM progresses rapidly and results in a high mortality rate. The present study aims to investigate the expression of microphthalmia transcription factor (MITF), the S100 protein, and HMB-45 in MM and pigmented nevi. Read More

    Spontaneous regression of a conjunctival naevus.
    BMJ Case Rep 2016 Aug 31;2016. Epub 2016 Aug 31.
    Department of Ophthalmology, John Radcliffe Hospital, Oxford, UK.
    Conjunctival naevi are one of the most common lesions affecting the conjunctiva. While benign in the vast majority of cases, the risk of malignant transformation necessitates regular follow-up. They are well known to increase in size; however, we present the first photo-documented case of spontaneous regression of conjunctival naevus. Read More

    Spontaneous Regression of a Congenital Melanocytic Nevus by Sclerosis.
    Pediatr Dermatol 2016 Nov 30;33(6):e368-e371. Epub 2016 Aug 30.
    Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
    Congenital melanocytic nevi (CMNs) naturally evolve throughout life, growing proportionately with the child, darkening, and exhibiting textural or surface changes (e.g., papillomatous, verrucous, cerebriform), hypertrichosis, and, later in life, lightening of pigmentation. Read More

    Reexamining the Threshold for Reexcision of Histologically Transected Dysplastic Nevi.
    JAMA Dermatol 2016 Dec;152(12):1327-1334
    Dermatology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California2Pigmented Lesion and Melanoma Program, Department of Dermatology, Stanford University Medical Center and Cancer Institute, Stanford, California.
    Importance: Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN).

    Objective: To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins.

    Design, Setting, And Participants: Retrospective cohort study of mixed referral and community patients from an academic pigmented lesion clinic and dermatology clinics of the affiliated Veteran Affairs medical center with biopsy-confirmed DN with positive histologic margins diagnosed from May 15, 1991, to July 8, 2015, and followed up through May 30, 2016. Read More

    Melanocytic Nevi in Children: A Review.
    Pediatr Ann 2016 Aug;45(8):e293-8
    Common moles on the skin, known scientifically as melanocytic nevi, are seen frequently in the pediatric population. They are broadly grouped into two groups: congenital (generally present at birth or in infancy) or acquired. Congenital melanocytic nevi (CMN) are classified based on size and morphologic features. Read More

    [Intramedullary melanocytoma: a clinical case report and literature review].
    Zh Vopr Neirokhir Im N N Burdenko 2016;80(4):75-80
    Burdenko Neurosurgical Institute, Moscow, Russia.
    The paper describes a rare clinical case of intramedullary melanocytoma, provides a detailed description of a pathomorphological study, and addresses the issues of differential diagnosis and surgical treatment. Read More

    Common Pediatric Skin Lesions: A Comprehensive Review of the Current Literature.
    Semin Plast Surg 2016 Aug;30(3):91-7
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    The timely diagnosis and treatment of dermatologic disease in the pediatric population can be challenging. A basic, yet comprehensive knowledge of common lesions is essential for a successful practice in plastic surgery. In this article, the authors describe vascular, cystic, and pigmented cutaneous lesions that are commonly encountered in the pediatric population. Read More

    Complete regression of primary cutaneous malignant melanoma associated with distant lymph node metastasis: a teaching case mimicking blue nevus.
    BMC Res Notes 2016 Jul 26;9:366. Epub 2016 Jul 26.
    Department of Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Background: Malignant melanoma (MM) tends to be spontaneously regressed, however, complete regression of primary cutaneous MM is an extremely rare phenomenon. Our aim is to be aware that pathologists and/or dermatologists can readily misinterpret it as the other benign or malignant lesions.

    Case Presentation: A gradually growing and verrucous hypopigmented macule had been noticed in the right sole of a 65-year-old Japanese male since 2 years before, and it turned to be a solitary bluish to black patch with surrounding depigmentation and was recently decreased in size. Read More

    Treatment of nasal ala nodular congenital melanocytic naevus with carbon dioxide laser and Q-switched Nd:YAG laser.
    Lasers Med Sci 2016 Nov 22;31(8):1627-1632. Epub 2016 Jul 22.
    Department of Plastic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, YanJiang Xi Road, No. 107, Guangzhou, 510120, People's Republic of China.
    Total excision of congenital melanocytic nevi (CMN) is not always feasible. We here present our experience of using carbon dioxide laser and Q-switched neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser to treat nodular CMN of the nasal ala. Q-switched Nd:YAG laser and/or carbon dioxide laser were used to treat eight cases of nasal ala nodular CMN. Read More

    Osteonevus of Nanta Presenting as Flesh-Colored Papule of Cheek Following Laser Ablation.
    J Craniofac Surg 2016 Sep;27(6):e543-4
    Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
    Osteonevus of Nanta is a melanocytic nevus displaying secondary ossification and carrying a potential for malignancy. A solitary occurrence is reported herein, presenting as a flesh-colored papule following laser ablation.A 56-year-old woman sought treatment for a minor papular growth of the cheek. Read More

    Age related changes in brain MR appearance in the course of neurocutaneous melanosis.
    Eur J Radiol 2016 Aug 24;85(8):1427-31. Epub 2016 May 24.
    Clinic of Surgery of Children and Adolescents, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland.
    Background: Patients with giant congenital melanocytic nevi (GCMN) have increased risk of neurocutaneous melanosis (NCM). Brain MRI is mandatory in GCMN.

    Objectives: To present the age related changes in brain MRI in children with NCM during several-year follow-up. Read More

    Blue Rubber Bleb Nevus Syndrome with Musculo-skeletal Involvement and Pulmonary Stenosis.
    Indian Pediatr 2016 Jun;53(6):525-7
    Departments of Dermatology and STD, and *Radiology, University College of Medical Sciences and GTB Hospital (University of Delhi), Dilshad Garden, Delhi, India. Correspondence to: Dr (Prof) Archana Singal, University College of Medical Sciences and GTB Hospital, Delhi 110 095, India.
    Background: Blue rubber bleb nevus syndrome is a rare clinical entity.

    Case Characteristics: A 13-year-old Indian boy presented with characteristic cutaneous lesions, gastrointestinal malformations, skeletal involvement and pulmonary stenosis.

    Observations: Diagnosis was confirmed on skin biopsy, radiographic evaluation, colonoscopy and echocardiography. Read More

    Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis.
    Case Rep Pathol 2016 26;2016:8107671. Epub 2016 May 26.
    Department of Pathology, Rijeka University School of Medicine, Braće Branchetta 20, 51000 Rijeka, Croatia.
    A case of a 41-year-old woman with a history of nodular melanoma (NM), associated with an indurated dome-shaped blue-black nodule with a diameter of 1.2 cm in the gluteal region, is presented. Clinical diagnosis of the lesion, present from birth, was blue nevus. Read More

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