10,998 results match your criteria Halo Nevus

PRAME Immunohistochemistry is Useful in the Evaluation of Conjunctival Melanomas, Nevi, and Primary Acquired Melanosis.

J Cutan Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Surgery, Section of Ophthalmology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Many dermatopathologists find conjunctival melanocytic proliferations challenging because they are rare relative to their cutaneous counterparts and have nuanced morphology and nomenclature. PRAME immunohistochemistry has been widely adopted for distinguishing cutaneous nevi from melanoma, but limited data exist assessing its utility in evaluating conjunctival specimens. In particular, it is uncertain whether it can predict the risk of melanoma progression in primary acquired melanosis (PAM). Read More

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Treatment of Congenital Melanocytic Nevi With a Dual-Wavelengths Copper Vapor Laser: A Case Series.

J Lasers Med Sci 2021 14;12:e5. Epub 2021 Feb 14.

Clinic of Aesthetic Medicine. Head of the Laser Department of the Health Institute, Kharkiv, 61000, Ukraine.

Congenital melanocytic nevus (CMN) is a severe challenge for dermatology. This pigmented skin lesion is undesirable for patients because of its localization in open areas of the body. Various visible and near-infrared laser systems and intense pulsed light (IPL) sources have been applied for CMN treatment. Read More

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February 2021

[Reed nevus and cutaneous melanoma in children: an immunohistochemical study].

Arkh Patol 2021 ;83(3):30-34

Blokhin National Medical Research Center of Oncology, Moscow, Russia.

Certain difficulties arise in the differential diagnosis between Reed nevus that is common in children and adolescents and cutaneous melanoma that is extremely rare in patients of this age group. In addition to the classical histological examination, an immunohistochemical test for marker proteins is carried out to improve the accuracy of the diagnosis of pigmented skin neoplasms.

Objective: To evaluate the suitability of a set of proteins (cyclin D1, p16, and HLA class I antigens) in the differential diagnosis of Reed nevus and cutaneous melanoma in children and adolescents. Read More

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Spitz nevus with a novel TFG-NTRK2 fusion: The first case report of NTRK2-rearranged Spitz/Reed nevus.

J Cutan Pathol 2021 May 12. Epub 2021 May 12.

Department of Biopathology, Center Léon Bérard, Lyon, France.

Fusions of ALK, ROS1, NTRK1, NTRK3, RET, MET, MERTK, FGFR1, ERBB4, LCK, BRAF, MAP3K8, MAP3K3, and PRKDC and mutation of HRAS have so far been discovered as the genetic alterations associated with the pathogenesis of Spitz neoplasms. This report presents the first case of NTRK2-rearranged Spitz/Reed nevus. The patient was a 39-year-old male with a pigmented macule rapidly growing on his shoulder. Read More

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Cholesterol was identified as a biomarker in human melanocytic nevi using DESI and DESI/PI mass spectrometry imaging.

Talanta 2021 Aug 29;231:122380. Epub 2021 Mar 29.

National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, 230029, China. Electronic address:

The rapid differentiation between diseased tissue and healthy normal tissue is of great importance for the intraoperative diagnosis. Herein, desorption electrospray ionization (DESI) and DESI/post-photoionization (DESI/PI) mass spectrometry imaging were combined to in situ visualize the distribution of biochemicals within the tissue regions of human melanocytic nevi under the ambient condition with a spatial resolution of around 200 μm. Plenty of polar and nonpolar lipids were found to be specifically distributed in melanocytic nevi with statistical significance and could be used to differentiate the healthy normal tissue and melanocytic nevi. Read More

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Basal cell nevus syndrome with excessive basal cell carcinomas.

Arch Craniofac Surg 2021 Apr 20;22(2):122-125. Epub 2021 Apr 20.

Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea.

Basal cell nevus syndrome (BCNS), also known as basal cell carcinoma nevus syndrome, Gorlin syndrome, Gorlin-Goltz syndrome, and nevoid basal cell carcinoma, is a rare autosomal dominant disorder with a prevalence of approximately 1/60,000. A lower prevalence rate of 1/13,939,393 has also been reported in Korea. We report the case of a 40-year-old male patient with multiple black pigmented macules on the face that first appeared when he was a teenager. Read More

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[Clinicopathological features and prognosis of nodal nevi].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):494-499

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Institute of Pathology, Fudan University, Shanghai 200032, China.

To investigate the clinicopathological characteristics, differential diagnosis and prognosis of nodal nevi (NN). Eighteen cases of NN diagnosed at Fudan University Shanghai Cancer Center, Shanghai, China from 2009 to 2019 were collected. The clinicopathological characteristics and follow-up data were retrospectively analyzed. Read More

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ABCDE of a pigmented caruncular lesion.

Indian J Ophthalmol 2021 05;69(5):1031

The MUHC - McGill University Ocular Pathology and Translational Research Laboratory, McGill University; Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.

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Three-dimensional histological explanation of the dermoscopy patterns in acral melanocytic lesions.

J Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. Read More

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Melanocytic lesions with peripheral globules: still a pitfall in the differential diagnosis of melanoma.

J Eur Acad Dermatol Venereol 2021 May;35(5):1040

Second Department of Dermatology-Venereology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

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A Segmentation of Melanocytic Skin Lesions in Dermoscopic and Standard Images Using a Hybrid Two-Stage Approach.

Biomed Res Int 2021 6;2021:5562801. Epub 2021 Apr 6.

Department of Medical Biotechnology, Dongguk University-Bio Medi Campus, 10326, Republic of Korea.

The segmentation of a skin lesion is regarded as very challenging because of the low contrast between the lesion and the surrounding skin, the existence of various artifacts, and different imaging acquisition conditions. The purpose of this study is to segment melanocytic skin lesions in dermoscopic and standard images by using a hybrid model combining a new hierarchical -means and level set approach, called HK-LS. Although the level set method is usually sensitive to initial estimation, it is widely used in biomedical image segmentation because it can segment more complex images and does not require a large number of manually labelled images. Read More

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Concurrence of peripunctal nevus and uveal melanoma with scleral pigment dispersion presenting as phthisis bulbi.

BMJ Case Rep 2021 Apr 16;14(4). Epub 2021 Apr 16.

Ocular Oncology, The Operation Eyesight Univeraal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, Telangana, India

This case report demostrates an unusual occurence of peripunctal nevus and uveal melanoma, in which the clinical diganosis of uveal melanoma was masked by the atypical presentation as phthisis bulbi. Nevertheless, peculiar scleral pigment hinted at a possible intraocular tumour. The importance of meticulous clinical examination in assessment of ocular and periocular pigmented lesions is demonstrated. Read More

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Adopting low-shot deep learning for the detection of conjunctival melanoma using ocular surface images.

Comput Methods Programs Biomed 2021 Jun 3;205:106086. Epub 2021 Apr 3.

B&VIIT Eye Center, Seoul, South Korea; VISUWORKS, Seoul, South Korea.

Background And Objective: The purpose of the present study was to investigate low-shot deep learning models applied to conjunctival melanoma detection using a small dataset with ocular surface images.

Methods: A dataset was composed of anonymized images of four classes; conjunctival melanoma (136), nevus or melanosis (93), pterygium (75), and normal conjunctiva (94). Before training involving conventional deep learning models, two generative adversarial networks (GANs) were constructed to augment the training dataset for low-shot learning. Read More

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Disseminated Nonsegmental Vitiligo Associated With Halo Nevi and Premature Gray Hair.

Cureus 2021 Mar 13;13(3):e13868. Epub 2021 Mar 13.

Dermatology, Henry Ford Health System, Detroit, USA.

Halo nevi (HN) are acquired melanocytic nevi circumferentially surrounded by a depigmented patch. HN are commonly associated with vitiligo and can be associated with uveal, mucosal, or cutaneous melanoma in certain patient populations. HN may also have localized leukotrichia of terminal hair overlying the nevus. Read More

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Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi.

Case Rep Dermatol Med 2021 22;2021:6672528. Epub 2021 Mar 22.

Dermatology Department, CHU UCL Namur, Site Sainte Elisabeth, Place Louise Godin 15, 5000 Namur, Belgium.

Background: Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Documented growth of a halo choroidal nevus.

J Fr Ophtalmol 2021 Apr 5. Epub 2021 Apr 5.

Ocular oncology service, Moorfields Eye Hospital NHS Foundation Trust, 162, City road, EC1V 2PD London, United Kingdom; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, United Kingdom.

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Blue rubber bleb nevus syndrome associated with tuberous sclerosis complex and CNS involvement.

Neurosciences (Riyadh) 2021 Apr;26(2):207-211

From the Department of Neuroscience, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder that is characterized by multiple dome-shaped cutaneous venous malformations on the skin and visceral organs. Typical extra-cutaneous lesions have the appearance of blueish nipple-shaped nodules that can easily compress and refill. We described a rare case of a 23-year-old female with BRBNS and tuberous sclerosis complex (TSC) that presented with central nervous system (CNS) involvement including unprovoked focal impaired awareness seizure. Read More

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Phacomatosis spilorosea versus phacomatosis melanorosea: a critical reappraisal of the worldwide literature with updated classification of phacomatosis pigmentovascularis.

Daniele Torchia

Acta Dermatovenerol Alp Pannonica Adriat 2021 Mar;30(1):27-30

Department of Dermatology, James Paget University Hospital, Gorleston-on-Sea, United Kingdom.

Introduction: Phacomatosis pigmentovascularis is a term encompassing a group of disorders characterized by the coexistence of a segmental pigmented nevus of melanocytic origin and segmental capillary nevus. Over the past decades, confusion over the names and definitions of phacomatosis spilorosea, phacomatosis melanorosea, and their defining nevi, as well as of unclassifiable phacomatosis pigmentovascularis cases, has led to several misplaced diagnoses in published cases.

Methods: A systematic and critical review of the worldwide literature on phacomatosis spilorosea and phacomatosis melanorosea was carried out. Read More

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Four-color Halo Congenital Nevus.

J Cosmet Dermatol 2021 Mar 9. Epub 2021 Mar 9.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Halo nevus (HN), also termed leukoderma acquisitum centrifugum or Sutton nevi, typically consists of central nevomelanocytic nevi surrounded depigmented zone resembling halo. The halo phenomenon can also occur around neurofibroma basal cell carcinomas, or malignant melanoma. Here we present a case of four-color halo nevus presented with a pink papule successively surrounded by a depigmented and a hypopigmented halo on a brown background. Read More

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In vivo reflectance confocal microscopy of halo nevi.

Skin Res Technol 2021 Mar 10. Epub 2021 Mar 10.

Department of Dermatology, University of Trieste, Trieste, Italy.

Introduction: Halo nevi named also Sutton's nevi are uncommon melanocytic lesions occurring especially among adolescents. There are two effective diagnostic methods: dermoscopy and in vivo reflectance confocal microscopy (RCM), which can help us to observe many structural elements and characteristic features of Sutton's nevi.

Objectives: The aim of this study was to describe reflectance confocal microscopy features of halo nevi. Read More

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Treatment of scarring alopecia from trauma and surgical procedures in young patients using follicular unit hair transplantation.

Pediatr Dermatol 2021 Mar 18. Epub 2021 Mar 18.

Department of Plastic Reconstructive Surgery, Osaka Medical College, Takatsuki City, Japan.

Introduction: Hair loss due to scarring as a consequence of surgical procedures and trauma can impact young patients socially and emotionally. Recently follicular unit extraction (FUE) hair transplantation has been applied to scar treatment.

Patients And Methods: This report included four patients with scarring alopecia. Read More

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[Correlation study of superantigens and formation of human ear keloid].

Zhonghua Shao Shang Za Zhi 2021 Mar;37(3):257-262

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong 226001, China.

To investigate the correlation of superantigens and human ear keloid formation. The retrospective case-control study method was used. The discarded keloid tissue was collected from 10 patients (9 females and 1 male, aged 19-59 years) with ear keloid after core excision of ear keloid, and the discarded normal skin tissue was collected from 3 female patients (aged 20-24 years) with pigmented nevus after operation, who were admitted to affiliated Hospital of Nantong University from June 2017 to March 2018. Read More

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Multimodal imaging of a choroidal nevus with caverns in the setting of pachychoroid disease.

Retin Cases Brief Rep 2021 Feb 26. Epub 2021 Feb 26.

Doheny Eye Institute, Los Angeles, California, United States. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States. Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy. Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Vitreous Retina Macula Consultants of New York, New York, New York. Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY USA.

Purpose: To describe the multimodal imaging findings of extensive choroidal caverns within a choroidal nevus in an eye with pachychoroid spectrum disease.

Methods: A 69 year-old woman was referred with a known history of branch retinal vein occlusion (BRVO) in the right eye and choroidal nevus in the left eye. Fundus examination of both eyes (OU) revealed subretinal yellow deposits, suggestive of pachydrusen. Read More

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February 2021

Multidisciplinary Pigmented Lesion Clinic at Auckland District Health Board: impacts on melanoma diagnosis and treatment outcomes.

N Z Med J 2021 02 19;134(1530):30-37. Epub 2021 Feb 19.

Dermatologist, Dermatology Department, Auckland District Health Board, Auckland.

Aim: To investigate the outcomes and effect of a multidisciplinary 'see and treat' pigmented lesion clinic, run jointly by dermatology and general surgery, on the diagnosis and treatment of melanoma at Auckland District Health Board (DHB).

Method: All patients attending the newly established Pigmented Lesion Clinic (PLC) between 1 March 2019 and 31 August 2019 were included in the study. They were compared against a retrospective cohort of patients seen for suspected or biopsy-proven melanomas during the same corresponding period in 2016. Read More

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February 2021

Commentary: Atypical melanocytic skin lesions - does the anatomical location have an impact on their clinical and dermoscopic appearance?

T Deinlein

J Eur Acad Dermatol Venereol 2021 03;35(3):566

Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

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Management of Inflamed Conjunctival Nevus with Topical Antiallergic Medications: Case Series.

Clin Ophthalmol 2021 12;15:559-564. Epub 2021 Feb 12.

Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.

Purpose: To report our findings in three cases of an inflamed conjunctival nevus whose size and degree of pigmentation were reduced by topical antiallergic and immunosuppressive ophthalmic solutions.

Methods: Observational case series. Three patients with inflamed conjunctival nevus were examined by slit-lamp biomicroscopy, and the findings before and after the treatments were compared. Read More

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February 2021

Giant spotted grouped pigmented nevus: A case report.

J Cutan Pathol 2021 Feb 17. Epub 2021 Feb 17.

Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Spotted grouped pigmented nevus is a distinct form of non-giant congenital melanocytic nevi. Histopathologically, it tends to proliferate around the skin appendages. We report a case of a 10-year-old boy with clinical and pathological findings consistent with the diagnosis of spotted grouped pigmented nevus of more than 20 cm diameter, which is considered giant. Read More

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February 2021

Line-field confocal optical coherence tomography of benign dermal melanocytic proliferations: a case series.

J Eur Acad Dermatol Venereol 2021 Jun 28;35(6):e399-e401. Epub 2021 Feb 28.

Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

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Treatment of maxillofacial congenital melanocytic nevus with percutaneous radiofrequency thermal ablation: A case series study.

Dermatol Ther 2021 03 21;34(2):e14876. Epub 2021 Feb 21.

Department of Rehabilitation Medicine, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.

When congenital melanocytic nevus (CMN) is in the maxillofacial region, a safer, more effective and fewer side-effects treatment is needed for patients with high requirement for appearance. The objective of this study was to investigate the effectiveness of radiofrequency thermal ablation (RFA) for CMN in the maxillofacial region. We reviewed 21 patients treated with RFA for CMN followed by a blinded retrospective analysis of serial photographs taken during the course of their therapy. Read More

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