10,221 results match your criteria Halo Nevus


Lasers for Becker's nevus.

Lasers Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.

Becker's nevus is a common pigmented dermatosis, usually featured by ipsilateral pigmented patch with hypertrichosis. Becker's nevus is often treated with various types of lasers although other regimens are available. However, clinical outcomes appear inconsistent among studies. Read More

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http://dx.doi.org/10.1007/s10103-019-02734-3DOI Listing
February 2019

[The application of modified rhomboid flap in repairing facial skin and soft tissue defect].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):207-211

Department of Plastic Surgery, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China.

Objective: To explore the effectiveness of modified rhomboid flap for repairing facial skin and soft tissue defect.

Methods: Between January 2016 and May 2018, 23 patients with facial skin and soft defect were repaired by the modified rhomboid flap. There were 10 males and 13 females with the median age of 27 years (range, 11-72 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201810020
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http://dx.doi.org/10.7507/1002-1892.201810020DOI Listing
February 2019
2 Reads

Peritumoral clefting as a key feature in differentiating basal cell carcinoma from trichoblastoma through in-vivo reflectance confocal microscopy.

J Eur Acad Dermatol Venereol 2019 Feb 5. Epub 2019 Feb 5.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Adnexal tumors represent one of the most troublesome differential diagnosis when dealing with skin lesions with clinical and dermoscopic criteria suggestive for basal cell carcinoma (BCC). Among these, benign follicular tumors, and in particular trichoblastoma and trichoepithelioma, deserve a special mention as BCC mimickers. These are benign tumors showing differentiation toward the outer follicular sheath. Read More

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http://dx.doi.org/10.1111/jdv.15467DOI Listing
February 2019
10 Reads

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
February 2019
1 Read

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
January 2019
2 Reads

Clinicopathologic, misdiagnosis and survival differences between clinically amelanotic melanomas and pigmented melanomas.

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Pigmented Lesion Clinic and Cutaneous Oncology Program, Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

Background: Amelanotic malignant melanoma (AMM) is challenging to diagnose. Clinical risk factors for AMM are not well defined.

Objective: To investigate clinicopathologic, misdiagnosis and survival differences between AMM versus (vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622193008
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http://dx.doi.org/10.1016/j.jaad.2019.01.012DOI Listing
January 2019
8 Reads
4.449 Impact Factor

Hyperspectral imaging in automated digital dermoscopy screening for melanoma.

Lasers Surg Med 2019 Jan 17. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

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http://doi.wiley.com/10.1002/lsm.23055
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http://dx.doi.org/10.1002/lsm.23055DOI Listing
January 2019
30 Reads

[Repair of skin and soft tissue defects of auricle and donor site with relay flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):66-69

Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China.

Objective: To investigate the effectiveness of relay flap on repairing skin and soft tissue defect of auricle and donor site.

Methods: Between May 2014 and January 2016, 10 patients with auricular tumor were repaired by relay flap. There were 4 males and 6 females with an average age of 35 years (range, 21-69 years). Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807141
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http://dx.doi.org/10.7507/1002-1892.201807141DOI Listing
January 2019
5 Reads

Incidence of melanoma and outcomes of longitudinal melanonychia in a cohort of cases referred to a London dermatology department.

Authors:
Z Jiyad V Akhras

Br J Dermatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Dermatology, St George's Hospital, London, United Kingdom.

Longitudinal melanonychia is a pigmented longitudinal band on the nail plate and may occur due to melanocyte activation, nail matrix nevus, lentigo or subungual melanoma. In a racially diverse community, melanonychia is a relatively common presenting complaint. However, despite this, little is known about the incidence of melanoma in longitudinal melanonychia, as well as variations in management approaches. Read More

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http://dx.doi.org/10.1111/bjd.17607DOI Listing
January 2019
1 Read

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
7 Reads

Histopathologic correlation of high-risk MelaFind lesions: a 3-year experience from a high-risk pigmented lesion clinic.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.

Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14336
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http://dx.doi.org/10.1111/ijd.14336DOI Listing
December 2018
7 Reads

Spontaneous Regression of Large Congenital Melanocytic Nevi, With a Halo Rim in 17 Children With Large Scalp and Trunk Nevi During 45 Years: A Review of the Literature.

Clin Pediatr (Phila) 2018 Dec 3:9922818816421. Epub 2018 Dec 3.

1 University of Miami, Miami, FL, USA.

Background: Prior reports on large congenital melanocytic nevi (LCMN) do not provide a clear management approach to physicians to advise parents or patients. Whether the presence of a halo around the nevus can guide management has not been fully explored.

Design: Children born with an LCMN were observed without active intervention. Read More

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http://dx.doi.org/10.1177/0009922818816421DOI Listing
December 2018
2 Reads

[miR-122-5p inhibits the proliferation of melanoma cells by targeting NOP14].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1360-1365

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China.

Objective: To investigate the expression profile of miR-122-5p in melanoma tissues and the effect of miR-122-5p on the proliferation, cell cycle and apoptosis of human melanoma cell lines SK-MEL-110 and A375.

Methods: The expression profiles of miR-122-5p in melanoma and pigmented nevus tissues were detected using real-time fluorescence quantitative PCR (qRT-PCR). SK-MEL-110 and A375 cells transfected with miR-122-5p inhibitor or negative control inhibitor (NC) I were examined for miR-122- 5p expression using qRT-PCR and changes in cell proliferation, cell cycle and apoptosis using MTT assay or flow cytometry. Read More

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http://www.j-smu.com/oa/darticle.aspx?type=view&id=20181
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http://dx.doi.org/10.12122/j.issn.1673-4254.2018.11.14DOI Listing
November 2018
9 Reads

Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Tongji hospital of Tongji University, Shanghai, China.

Objective: To investigate the effect of microRNA-137 (miR-137) on the migration and invasion of melanoma cells and its mechanism.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-137 in melanoma tissues and cells. miR-137 mimics, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) small interfering RNA and corresponding controls were transfected into A375 and WM451 cells by lipofection. Read More

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http://dx.doi.org/10.1002/jcb.28124DOI Listing
November 2018
2 Reads

Vertical plane ex vivo dermoscopy: a novel dermoscopic technique. A preliminary study.

An Bras Dermatol 2018 Nov/Dec;93(6):899-901

Department of Pathology, Santa Casa de São Paulo, São Paulo (SP), Brazil.

Dermoscopic examination allows visualization of horizontal images on the skin, showing well-defined patterns. The authors propose ex vivo dermoscopic visualization using a vertical view of skin sections. The new image clearly distinguishes the stratum corneum, epidermis, and dermis as well as the anatomical location of the pigment. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256214PMC
February 2019
2 Reads

Regressing Conjunctival Nevus in a Child.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):501-503

Liverpool Ocular Oncology Centre, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, England, UK.

Purpose: To report a case exhibiting drastic regression of a conjunctival nevus in a child.

Case Report: Spontaneous regression of conjunctival nevus is uncommon. We report the case of a nine-year-old Caucasian boy presenting a conjunctival-pigmented lesion situated at the plica semilunaris that underwent a significant reduction in size and color over a period of 15 months. Read More

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http://dx.doi.org/10.4103/jovr.jovr_215_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210859PMC
November 2018
5 Reads

NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 Dec 18;38(6). Epub 2018 Dec 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Melanoma-conditioned TAMs were obtained from human monocytes after incubation with conditioned medium from A375 cell culture. Read More

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http://dx.doi.org/10.1042/BSR20181604DOI Listing
December 2018
6 Reads

Nevus of Ota associated with a primary uveal melanoma and intracranial melanoma metastasis.

Cutis 2018 Sep;102(3):E2-E4

Department of Dermatology, University of Virginia, Charlottesville, USA.

Nevus of Ota is a blue, hyperpigmented, benign dermatosis of the skin and mucosae that most often occurs unilaterally in the distribution of the ophthalmic (V1) and maxillary (V2) branches of the trigeminal nerve. Although uncommon, association with malignant melanoma is a complication that must be considered in the evaluation of patients with nevus of Ota. Mutations in the and genes in patients with nevus of Ota place them at higher risk for malignant melanoma and metastasis. Read More

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September 2018
4 Reads

Pigmented Lesions of the Nail Unit.

Am J Dermatopathol 2018 Nov;40(11):793-804

Faculty in Dermatopathology, Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Pigmented lesions of the nail unit are commonly encountered in the clinical setting. Yet, they often present a unique challenge to clinicians because of a broad differential diagnosis or unfamiliarity with clinical and histopathologic features. A wide variety of causes exist ranging from benign lesions such as subungual hemorrhage to malignant lesions such as subungual melanoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001106DOI Listing
November 2018
3 Reads

A novel cumulative level difference mean based GLDM and modified ABCD features ranked using eigenvector centrality approach for four skin lesion types classification.

Comput Methods Programs Biomed 2018 Oct 24;165:163-174. Epub 2018 Aug 24.

Department of Electronics and Electrical Communications Engineering, Faculty of Engineering, Tanta University, Tanta, Egypt.

Background And Objective: Melanoma is one of the major death causes while basal cell carcinoma (BCC) is the utmost incident skin lesion type. At their early stages, medical experts may be confused between both types with benign nevus and pigmented benign keratoses (BKL). This inspired the current study to develop an accurate automated, user-friendly skin lesion identification system. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.08.009DOI Listing
October 2018
1 Read

Malignant Transformation of a Multi-Operated Divided Nevus of the Eyelids.

Ocul Oncol Pathol 2018 Sep 2;4(2):112-115. Epub 2017 Sep 2.

Institut Curie, Institut Curie, Paris, France.

A woman in her early fifties had regular follow-up for a medium-sized divided nevus of the eyelids which had undergone several surgical excisions during childhood for functional and esthetic reasons. Malignant transformation of the nevus occurred in the inferior eyelid, with the appearance of a new pigmented flat lesion. Histology showed in situ melanoma, and an NRAS activating mutation was found. Read More

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https://www.karger.com/Article/FullText/479069
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http://dx.doi.org/10.1159/000479069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167659PMC
September 2018
4 Reads

Risk of Subsequent Cutaneous Melanoma in Moderately Dysplastic Nevi Excisionally Biopsied but With Positive Histologic Margins.

JAMA Dermatol 2018 Dec;154(12):1401-1408

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Little evidence exists to guide the management of moderately dysplastic nevi excisionally biopsied without residual clinical pigmentation but with positive histologic margins (hereafter referred to as moderately dysplastic nevi with positive histologic margins).

Objective: To determine outcomes and risk for the development of subsequent cutaneous melanoma (CM) from moderately dysplastic nevi with positive histologic margins observed for 3 years or more.

Design, Setting, And Participants: A multicenter (9 US academic dermatology sites) retrospective cohort study was conducted of patients 18 years or older with moderately dysplastic nevi with positive histologic margins and 3 years or more of follow-up data collected consecutively from January 1, 1990, to August 31, 2014. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.3359DOI Listing
December 2018
12 Reads

DOCUMENTATION OF A NEW CHOROIDAL NEVUS.

Retin Cases Brief Rep 2018 Oct 3. Epub 2018 Oct 3.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.

Purpose: To describe the occurrence of an acquired choroidal nevus in a 73-year-old white man.

Methods: Case report.

Results: A 73-year-old white man was referred for an evaluation and treatment of macular changes in his left eye consistent with pachychoroid neovasculopathy. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000822DOI Listing
October 2018
11 Reads

Ipilimumab-associated halo-like inflammatory reactions around nevi during therapy for metastatic melanoma.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

University of Vermont Medical Center, Division of Dermatology, Burlington, Vermont.

Ipilimumab is an immune-modulating drug that is being used today for various cancers including metastatic malignant melanoma. Owing to its mechanism of action, several adverse events have been reported, including some affecting skin. In this work, we report a novel display of multiple ipilimumab-associated halo lichenoid reactions surrounding benign nevi during treatment of metastatic melanoma. Read More

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July 2018
4 Reads

A Case of Infundibulocystic Basal Cell Carcinoma Clinically Mimicking a Melanocytic Nevus Associated with Epidermal Cysts.

J Nippon Med Sch 2018 ;85(4):228-230

Department of Dermatology, Nippon Medical School.

A 52-year-old Japanese woman presented with a 1.5-cm black, glossy, flat, pediculated lump that clinically mimicked a melanocytic nevus on the left temporal side of her head. The subcutaneous tumor beneath the nodule was elastic and hard. Read More

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https://www.jstage.jst.go.jp/article/jnms/85/4/85_JNMS.2018_
Publisher Site
http://dx.doi.org/10.1272/jnms.JNMS.2018_85-35DOI Listing
November 2018
3 Reads

Measurement of size of pigmented choroidal nevus: Superiority of multicolor imaging compared to conventional color fundus photography.

Indian J Ophthalmol 2018 Oct;66(10):1501-1503

Retina Services, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Choroidal nevi are benign fundus lesions that require regular follow with documentation. Conventional color fundus photography (CFP) has traditionally been used to images these lesions. Multicolor imaging (MCI) available on Spectralis spectral domain optical coherence tomography system is increasingly been tested vis-à-vis conventional CFP in various retinal diseases. Read More

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http://dx.doi.org/10.4103/ijo.IJO_536_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173023PMC
October 2018
4 Reads

Dermoscopy for the Diagnosis of Conjunctival Lesions.

Dermatol Clin 2018 Oct 16;36(4):439-449. Epub 2018 Aug 16.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria Alle Scotte Hospital, Viale Bracci 16, Siena 53100, Italy.

This article describes the present literature on dermoscopy of conjunctiva and shows the results of a dermoscopy study of 147 conjunctival tumors. Melanomas were characterized by a heavy pigmentation, irregular dots, and a higher prevalence of gray color compared with nevi. Squamous cell carcinomas had peculiar hairpin and glomerular vessels. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.011DOI Listing
October 2018
24 Reads

Clinical spectrum of cutaneous melanoma morphology.

J Am Acad Dermatol 2019 Jan 28;80(1):178-188.e3. Epub 2018 Aug 28.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.

Objective: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters' clinicopathologic features.

Methods: All pathologic melanoma diagnoses (occurring during 2011-2016) were reviewed for routine prebiopsy digital photographs (n = 400). Read More

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http://dx.doi.org/10.1016/j.jaad.2018.08.028DOI Listing
January 2019
29 Reads
4.450 Impact Factor

Dermoscopic features of acral melanocytic nevi in a case series from Mexico.

An Bras Dermatol 2018 Sep-Oct;93(5):665-670

Dermatology Service, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Nuevo León, Mexico.

Background: Pigmented lesions on acral sites are common; clinical differentiation of nevi and early melanoma can be challenging. In these cases, dermoscopy can provide a more accurate diagnosis. Most dermoscopic patterns on acral skin have been described in Asian and European populations, while there are few studies in Latin American populations. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106682PMC
October 2018
7 Reads

A Case of Using Hominis Placenta and Soyeom Mixed Pharmacopuncture to Remove Melanocytic Nevus.

Authors:
Hyung-Sik Seo

J Pharmacopuncture 2018 Mar 31;21(1):14-17. Epub 2018 Mar 31.

Department of Ophthalmology, Otolaryngology and Dermatology, School of Korean Medicine, Pusan National University.

Objective: It has been attempted to find out that Homine Placents and Soyeom mixed Pharmacopuncture (HSP) procedure is effective for the removal of melanocytic nevus of considerable size which cannot be applied to general acupuncture.

Methods: Hominis placenta (0.5ml) and Soyeom (0. Read More

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http://www.journal.ac/sub/view/235
Publisher Site
http://dx.doi.org/10.3831/KPI.2018.21.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054075PMC
March 2018
2 Reads

A female infant with phacomatosis pigmentovascularis and congenital chylous ascites: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e12012

Department of Urology Surgery, Beijing Children's Hospital, National Center for Children's Health.

Rationale: Phacomatosis pigmentovascularis (PPV) is a rare syndrome characterized by capillary malformation and pigmentary nevus. Congenital chylous ascites (CCA) is also a rare disease that results from maldevelopment of the lymphatic system. We report a case of a 5-month-old girl, who had both PPV and CCA. Read More

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http://dx.doi.org/10.1097/MD.0000000000012012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112933PMC
August 2018
3 Reads

Eruptive melanocytic nevi in HIV infected patients: report of three cases.

Dermatol Online J 2018 Jun 15;24(6). Epub 2018 Jun 15.

Clinica Universitaria de Dermatologia de Lisboa, Centro Hospitalar Lisboa Norte, EPE (CHLN) - Lisbon.

The abrupt development of multiple melanocytic nevi has been described in association with many conditions, including human immunodeficiency virus infection. We report three cases of eruptive nevi in men with human immunodeficiency virus type 1 infection. One patient developed this phenomenon during the stage of acquired immunodeficiency syndrome. Read More

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June 2018
2 Reads

Tri-phenotypic naevus: a case report.

Pathology 2018 Oct 16;50(6):691-693. Epub 2018 Aug 16.

Département of Biopathology, Centre Leon Bérard, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2018.04.004DOI Listing
October 2018

Surgical management of a conjunctival nevus with amniotic membrane transplantation.

Int Med Case Rep J 2018 27;11:161-165. Epub 2018 Jul 27.

Centre for Ophthalmology, University of Tübingen, Tübingen, Germany,

Purpose: Nevi of the conjunctiva are usually benign pigmented tumorous lesions located in the bulbar conjunctiva. In most conjunctival nevus cases, the patient wants the lesion to be removed for cosmetic reasons, but excisional biopsies are best for lesions suspicious for malignancy. This case report illustrates the intraoperative surgical management, histological findings, and the course of healing in a conjunctival nevus patient. Read More

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http://dx.doi.org/10.2147/IMCRJ.S164099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067617PMC
July 2018
1 Read

Inflammatory juvenile compound nevi: A melanoma is not all that it appears to be.

Arch Soc Esp Oftalmol 2019 Feb 8;94(2):90-94. Epub 2018 Aug 8.

Servicio de Córnea y Cirugía Refractiva, Asociación Para Evitar la Ceguera en México, Ciudad de México, México.

An 11 year-old girl presented with a recent growth pigmented conjuntival lesion in the bulbar conjunctiva of left eye. Due to the the biomicroscopic and ultrasound findings, an excisional biopsy was performed on the lesion using the «no touch» technique, as well as cryo-coagulation of surgical margins. Histopathological examination revealed an inflammatory compound nevus. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.06.022DOI Listing
February 2019
2 Reads

Euromelanoma in Portugal. How useful was the Euromelanoma campaign between 2010 and 2017?

Int J Dermatol 2018 10 9;57(10):e85-e88. Epub 2018 Aug 9.

Portuguese Skin Cancer Association, Porto, Portugal.

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http://dx.doi.org/10.1111/ijd.14179DOI Listing
October 2018
2 Reads

Histogenetic categorization of atypical melanocytic tumor of uncertain biological malignant potential.

Authors:
Teresa Pusiol

An Bras Dermatol 2018 Jul-Aug;93(4):608-609

Institute of Anatomic Pathology, Rovereto Hospital, Rovereto (TN), Italy.

Several reports have demonstrated difficulties and lack of agreement in the histopathological diagnosis of particular melanocytic lesions, with problems in their management. A histogenetic approach to the study of these lesions originated the following classification: 1. superficial atypical proliferation significance; 2. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063103PMC
September 2018
4 Reads

Deep Tissue Sequencing Using Hypodermoscopy and Augmented Intelligence to Analyze Atypical Pigmented Lesions.

J Cutan Med Surg 2018 Nov/Dec;22(6):583-590. Epub 2018 Aug 1.

3 Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Over the past decade, new technologies, devices, and methods have been developed to assist in the diagnosis of cutaneous melanocytic lesions.

Objective: Our objective was to evaluate the performance of an augmented intelligence system in the assessment of atypical pigmented lesions.

Methods: Nine atypical pigmented lesions on 8 patients were evaluated prior to surgical removal. Read More

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http://dx.doi.org/10.1177/1203475418792000DOI Listing
January 2019

Extensive Mongolian spots and normocephaly: an uncommon presentation of infantile Sandhoff's disease.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Radiodiagnosis & Imaging, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

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http://dx.doi.org/10.1136/bcr-2018-225013DOI Listing
July 2018
4 Reads

Radotinib-induced eruptive melanocytic nevi in patient with chronic myeloid leukemia: a case report and literature review.

Ann Hematol 2019 Feb 21;98(2):533-535. Epub 2018 Jul 21.

Department of Dermatology, Veterans Health Service Medical Center, 53 Jinhwang-doro 61-gil, Gangdong-gu, Seoul, 05368, South Korea.

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http://dx.doi.org/10.1007/s00277-018-3444-0DOI Listing
February 2019
2 Reads

Optimizing Q-switched lasers for melasma and acquired dermal melanoses.

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):10-17

Department of Dermatology, Skin and Laser Clinic, Hyderabad, Telangana, India.

The Q-switched Nd:YAG laser is an established modality of treatment for epidermal and dermal pigmented lesions. The dual wavelengths of 1064nm and 532nm are suited for the darker skin tones encountered in India. Though this laser has become the one of choice for conditions such as nevus of Ota, Hori's nevus and tattoos, its role in the management of melasma and other acquired dermal melanoses is not clear. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_1086_16DOI Listing
July 2018
5 Reads

Polypoidal lesions associated to choroidal naevus: spectrum of pachychoroid disease?

BMJ Case Rep 2018 Jul 18;2018. Epub 2018 Jul 18.

Department of Ophthalmology, Leicester Royal Infirmary, Leicester, UK.

A 78-year-old woman was referred by an optician for an incidental finding of peripapillary naevus in the absence of visual symptoms. On examination, the right eye showed a choroidal naevus of around 1.5 disc diameter, adjacent to the optic disc. Read More

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http://dx.doi.org/10.1136/bcr-2018-225571DOI Listing
July 2018
3 Reads

Margin Assessment for Punch and Shave Biopsies of Dysplastic Nevi.

J Drugs Dermatol 2018 Jul;17(7):810-812

Introduction: Biopsies of atypical melanocytic nevi are among the most commonly performed procedures by dermatologists. Margin assessment is often used to guide re-excision, but can be a point of confusion as negative margins reported in the planes of sections examined do not always reflect complete removal of a lesion. This study investigates the rates of false negative margins after both punch and shave biopsies. Read More

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July 2018
3 Reads

Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS and BRAF mutation-negative nodules.

Pediatr Dermatol 2018 Sep 12;35(5):e281-e285. Epub 2018 Jul 12.

Faculty of Medicine, University of Oslo, Oslo, Norway.

We report the case of a newborn boy with multinodular NRAS and BRAF mutation-negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age. Read More

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http://dx.doi.org/10.1111/pde.13595DOI Listing
September 2018
10 Reads

GROWTH OF PRESUMED CHOROIDAL NEVUS INTO MELANOMA OVER 4 YEARS IN BAP1 TUMOR PREDISPOSITION SYNDROME.

Retin Cases Brief Rep 2018 Jul 6. Epub 2018 Jul 6.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To report a case of presumed choroidal nevus that eventually grew into melanoma in a patient with family history of choroidal melanoma and germline BAP1 mutation.

Methods: Case report.

Results: A 55-year-old healthy white woman with a family history of uveal melanoma in her father, paternal aunt, and paternal cousin was referred for evaluation of an asymptomatic small pigmented choroidal lesion in her right eye, measuring 2 mm × 2 mm in basal diameter and 1 mm in thickness. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000772DOI Listing
July 2018
17 Reads

Atypical Nevi in a Patient After Toxic Epidermal Necrolysis.

Acta Dermatovenerol Croat 2018 Jun;26(2):183-185

Ružica Jurakić Tončić, MD, Department of Dermatovenereology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, There are few literature data about nevi in patients with a history of toxic epidermal necrolysis (TEN) and little recommendations for follow-up and risks of melanoma (MM). Eruptive melanocytic nevi (EMN) is a rare phenomenon that has been associated with bullous disorders, immunosuppression, and immunodeficiency, but in some cases can occur without precipitating factors (1). The etiology is largely unknown, but there is evidence that immunosuppression might play a crucial role in nevogenesis, probably due to the inability of the immune system to inhibit melanocytic (MC) proliferation (2,3). Read More

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June 2018
14 Reads

Germline BRCA1-associated protein 1 mutation presenting as BAP1 inactivated melanocytic nevi in a child of a father with fatal paraganglioma.

Pediatr Dermatol 2018 Sep 4;35(5):e316-e318. Epub 2018 Jul 4.

Dermatology Department, Dorset County Hospital, Dorchester, United Kingdom.

BRCA1-associated protein 1(BAP1) inactivated melanocytic nevi are pink to tan and dome-shaped in clinical appearance, resembling dermal nevi, but with distinct histologic features of two melanocytic subpopulations: larger atypical melanocytes and nests of smaller, blander nevoid melanocytes. Pedigrees with BAP1 mutations are at greater risk of various malignancies. We report the case of a 16-year-old boy with multiple benign-appearing nevi, all demonstrating loss of BAP1 on immunohistochemistry. Read More

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http://dx.doi.org/10.1111/pde.13553DOI Listing
September 2018
15 Reads

Molluscum contagiosum arising in a melanocytic congenital nevus.

Pediatr Dermatol 2018 Sep 4;35(5):e310-e311. Epub 2018 Jul 4.

Section of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Molluscum contagiosum within a congenital melanocytic nevus has rarely been reported. We report a 6-year-old child with molluscum contagiosum infection arising within an intermediate melanocytic congenital nevus of the thigh, associated with itching and occasional bleeding. Dermoscopy lead to the correct diagnosis, but histologic confirmation with shave biopsy was performed to reassure the parents and allow mechanical removal of the lesions using curettage. Read More

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http://dx.doi.org/10.1111/pde.13591DOI Listing
September 2018
5 Reads

Phototherapy-induced blistering reaction and eruptive melanocytic nevi in a child with transient neonatal porphyrinemia.

Pediatr Dermatol 2018 Sep 1;35(5):e272-e275. Epub 2018 Jul 1.

Department of Dermatology and Allergology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.

Neonatal blue-light phototherapy induced a blistering reaction followed by eruption of melanocytic nevi on the exposed skin surface of a child with transient neonatal porphyrinemia. New nevi are still developing 4 years after the triggering event. The role of phototoxicity-induced epidermal injury, that of porphyrins and the influence of neonatal blue-light therapy, in this unique phenomenon are discussed. Read More

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http://dx.doi.org/10.1111/pde.13569DOI Listing
September 2018
4 Reads