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    Pigmented epithelioid melanocytoma (animal type melanoma): An institutional experience.
    J Am Acad Dermatol 2017 Apr 14. Epub 2017 Apr 14.
    Department of Dermatology, University of Rochester School of Medicine, Rochester, New York; Department of Pathology, University of Rochester School of Medicine, Rochester, New York.
    Background: Pigmented epithelioid melanocytoma (PEM) is an uncommon, recently described entity with unknown biologic behavior. There is a high rate of regional metastases, but limited evidence of distant metastases or disease-related death.

    Objective: We sought to report our series of patients given a diagnosis of PEM at our institution and provide mutational analysis of genes commonly implicated in melanoma in 2 cases. Read More

    A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.
    J Dermatol Sci 2017 Mar 19. Epub 2017 Mar 19.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, No. 127 Changlexi Road, Xi'an 710032, Shaanxi, China. Electronic address:
    Background: Vitiligo and halo nevus are two common T-cell-mediated skin disorders. Although autoimmunity has been suggested to be involved in both diseases, the relationship between vitiligo and halo nevus is not fully understood.

    Objective: The aim of the current study was to investigate whether vitiligo and halo nevus share the same immunological and oxidative stress response. Read More

    Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature.
    J Stomatol Oral Maxillofac Surg 2017 Mar 29. Epub 2017 Mar 29.
    Dental School of University of Seville, Spain.
    Introduction: Oral melanocytic nevi (OMNs) are uncommon benign melanocytic tumors, histologically similar to their cutaneous counterparts. The aim of this study was twofold: to contribute to the epidemiology with a literature review with the first Spanish series of OMNs, and to report on clinicopathological, immunohistochemical and demographic findings.

    Materials And Methods: A retrospective analysis of cases attended over the period 1999-2010 was carried out using data drawn from the pathology unit files at two public hospitals in the Spanish region of Andalusia, serving between them a population of 823. Read More

    Tissue expansion in the treatment of giant congenital melanocytic nevi of the upper extremity.
    Medicine (Baltimore) 2017 Mar;96(13):e6358
    aDepartment of Plastic Surgery bDepartment of Operating Theater, Henan Provincial People's Hospital, Zhengzhou City, Henan Province, China.
    The aim of our study was to use tissue expansion for the treatment of giant congenital melanocytic nevi of the upper extremity and examine potential advantages over traditional techniques.There were 3 stages in the treatment of giant congenital melanocytic nevi of the upper extremities using tissue expansion: first, the expander was inserted into the subcutaneous pocket; second, the expander was removed, lesions were excised, and the wound of the upper extremity was placed into the pocket to delay healing; third, the residual lesion was excised and the pedicle was removed. The pedicle flap was then unfolded to resurface the wound. Read More

    Special Considerations in Children with Vitiligo.
    Dermatol Clin 2017 Apr;35(2):229-233
    Centre de Référence des Maladies Rares de la Peau Hôpital Larrey - Service de Dermatologie 24, Chemin de Pouvourville TSA 30030, Toulouse Cedex 9 31059, France.
    Childhood vitiligo differs from adult-onset vitiligo for several features including increased incidence of the segmental variant, higher prevalence of halo nevi, and more common family history for autoimmune diseases and atopic diathesis. The major differential diagnoses are the postinflammatory hypomelanoses for nonsegmental vitiligo and nevus depigmentosus for segmental vitiligo. From a therapeutic standpoint, early awareness of the diagnosis seems to correlate with a good treatment outcome in this age group. Read More

    Immunohistochemical Study of Vasculogenic Mimicry and Angiogenesis in Melanocytic Tumors of the Eye and the Periocular Area.
    Anticancer Res 2017 03;37(3):1113-1120
    Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece.
    Background/aim: The ability of a tumor to grow requires a sufficient blood supply. Microvascular density is considered the standard for assessing the neovasculature. Tumor cell vasculogenic mimicry refers to the formation of tumor cell-lined vessels that contribute to tumor neovascularization. Read More

    Impression Cytology in a Series of Clinically Diagnosed Ocular Surface Melanocytic Lesions.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):17-22
    Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Purpose: To report impression cytology (IC) results of clinically diagnosed ocular surface melanocytic lesions.

    Methods: Ten patients with a clinical diagnosis of an ocular surface melanocytic lesion underwent IC using cellulose acetate strips and Periodic acid Schiff-Papanicolaou staining. Excisional biopsy of lesions was performed in case of observing atypical cells on IC or at the patient's request, and excised specimens were subjected to histopathological analysis. Read More

    Dermoscopic and confocal features of an axillary "special site" nevus.
    Dermatol Pract Concept 2017 Jan 31;7(1):55-58. Epub 2017 Jan 31.
    Department of Dermatology, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    "Nevi of special sites" is a term that denotes melanocytic nevi presenting in specific anatomic locations including the scalp, genital area, flexural sites, and acral sites [1]. Nevi from these anatomic sites display at times histopathologic features that may lead the reading pathologist to recommend re-excision of these benign nevi. Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that allows for visualization of epidermal, dermal-epidermal junctional (DEJ), and superficial dermal tissue structures at cellular level resolution. Read More

    Atypical cellular blue nevus or malignant blue nevus?
    An Bras Dermatol 2017 Jan-Feb;92(1):110-112
    Division of Dermatology, Internal Medicine Department - Medical School of Ribeirão Preto - Universidade de São Paulo- Ribeirão Preto (SP) -Brazil.
    Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progressive growth in the last two years. Read More

    Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.
    BMJ Case Rep 2017 Feb 13;2017. Epub 2017 Feb 13.
    Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex, UK.
    Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. Read More

    Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes.
    Curr Opin Ophthalmol 2017 May;28(3):228-237
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus.

    Recent Findings: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. Read More

    Polypoid Spitz Nevus With a Halo Reaction.
    Am J Dermatopathol 2017 Feb;39(2):130-133
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;†Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INER/CIENI, Hospital Angeles Lomas, Centro Medico ABC, Mexico City, Mexico; and‡Department of Pathology, Hospital Universitario 12 de Octubre, Universidad Complutense, I+12, Madrid, Spain.
    Approximately, 2% of Spitz nevi are polypoid; between 3.6% and 7.4% present with a halo reaction. Read More

    CLINICAL PROFILE AND TRIGGERING FACTORS FOR ACQUIRED, BILATERAL NEVUS OF OTA-LIKE MACULES.
    Cutan Ocul Toxicol 2017 Jan 25:1-14. Epub 2017 Jan 25.
    a Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , China.
    BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. Read More

    Evolution of Fibroblastic Connective Tissue Nevus in an Infant.
    Am J Dermatopathol 2017 Mar;39(3):225-227
    *Department of Pathology, West Virginia University, Morgantown, WV; and Departments of †Plastic Surgery, ‡Dermatology, §Pediatrics, and ¶Pathology, The Penn State Hershey Medical Center, Hershey, PA.
    Fibroblastic connective tissue nevus (FCTN) is a rare and recently described neoplasm of fibroblastic/myofibroblastic lineage. We report a case of a 1-month-old healthy male infant who presented with a dermal plaque on the upper chest since birth. A punch biopsy demonstrated a dermal spindle-cell neoplasm with variable smooth muscle actin positivity and negative staining for CD34, consistent with myofibroma. Read More

    Case Report of a Large Pigmented Epithelioid Melanocytoma With Suspected Lymph Node Metastases.
    Eplasty 2016 16;16:e33. Epub 2016 Dec 16.
    Departments of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Objective: Pigmented epithelioid melanocytoma was proposed by Zembowicz et al in 2004 including lesions previously diagnosed as human animal-type melanoma and epithelioid blue nevus. Tumors are composed of epithelioid and spindled melanocytes with heavy pigmentation. Methods: We report a case of pigmented epithelioid melanocytoma in 47-year-old Asian woman. Read More

    Nevus Spilus (Speckled Lentiginous Nevus) in the Oral Cavity: Report of a Case and Review of the Literature.
    Am J Dermatopathol 2017 Jan;39(1):e8-e12
    *Department of Oral and Maxillofacial Pathology, Naval Postgraduate Dental School, Bethesda, MD; and †Department of Pathology, Walter Reed National Medical Military Center, Bethesda, MD.
    The congenital melanocytic nevus is a pigmented melanocytic lesion that presents at birth or shortly thereafter. It is commonly described on the skin, usually on the trunk and extremities. Only five intraoral cases of congenital melanocytic nevi have been described in the English literature. Read More

    Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall.
    Ann Diagn Pathol 2017 Feb 14;26:43-46. Epub 2016 Nov 14.
    Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
    Background: Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. Read More

    5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms.
    J Cutan Pathol 2017 Mar 6;44(3):249-255. Epub 2017 Feb 6.
    Program in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: 5-Hydroxymethylcytosine (5-hmC) is an epigenetic marker detectable through immunohistochemistry (IHC) that has been shown to distinguish benign nevi from melanoma with high sensitivity and specificity. The purpose of the study was to explore its diagnostic utility in a subset of histologically challenging, heavily pigmented cutaneous melanocytic neoplasms.

    Methods: 5-hmC IHC was performed on 54 heavily pigmented melanocytic tumors. Read More

    IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations.
    J Immunol 2017 Jan 21;198(2):950-961. Epub 2016 Dec 21.
    Department of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294; and
    In animal models, IL-12 and IL-23 participate in the development of malignant neoplasms of keratinocytes. However, the role of these cytokines in pigmented lesion development and their progression to melanoma has received little attention. IL-12p35, IL-23p19, and IL-12/IL-23p40 knockout mice on a C3H/HeN background, subjected to a melanomagenesis protocol, demonstrated profound differences in susceptibility to nevus initiation, transformation, tumorigenicity, and metastatic potential. Read More

    Blue rubber bleb naevus syndrome: a rare cause of chronic occult blood loss and iron deficiency anaemia.
    BMJ Case Rep 2016 Dec 20;2016. Epub 2016 Dec 20.
    Department of Pediatrics, Aarhus Universitetshospital, Aarhus, Denmark.
    Blue rubber bleb naevus syndrome (BRBNS) is a rare vascular disorder with malformed veins, or blebs, appearing in the skin or internal organs. Gastrointestinal tract involvement is the most common feature and often subject to bleeding, potentially resulting in chronic occult blood loss and iron deficiency anaemia. We present the case of a 10-year-old boy with venous malformations on the feet and severe anaemia. Read More

    Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
    Semin Diagn Pathol 2017 Jan 29;34(1):99-107. Epub 2016 Nov 29.
    From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.
    This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

    Combination therapy in skin of color including injectables, laser, and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):211-217
    Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California, USA.
    With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Read More

    Pigmented oral compound nevus of retromolar area - A rare case report.
    Singapore Dent J 2016 Dec;37:33-35
    Department of Oral Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi. Electronic address:
    Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5. Read More

    Cutaneous Metastatic Melanoma Resembling a Halo Nevus, in the Setting of PD-1 Inhibition.
    Am J Dermatopathol 2016 Dec;38(12):e159-e162
    *Department of Anatomical Pathology, PathWest, QEII Medical Centre, Perth, Western Australia, Australia; †School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia; ‡Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia; §School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; and ¶Margaret River Surgery, Margaret River, Western Australia, Australia.
    Malignant melanoma is a common source of cutaneous metastases and can occasionally adopt a histological appearance which mimics a primary melanocytic lesion, either benign or malignant. The authors describe a case of new cutaneous deposits of metastatic melanoma in a 70-year-old woman with a prominent admixed lymphocytic infiltrate, imparting a striking resemblance to a halo nevus. The authors believe this appearance was a direct reflection of treatment with pembrolizumab, a humanized antibody against the immune checkpoint inhibitor programmed death-1. Read More

    Melanocytic Nevi of Special Sites.
    Am J Dermatopathol 2016 Dec;38(12):867-881
    *Resident, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC; †Dermatologist, International Dermatopathology Fellow, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC; and ‡Professor of Pathology and Dermatology, Director of Dermatopathology, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC.
    Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Read More

    BILATERAL DIFFUSE UVEAL MELANOCYTIC PROLIFERATION ASSOCIATED WITH RENAL CANCER: THE IMPORTANCE OF INDOCYANINE GREEN ANGIOGRAPHY AND EARLY DIAGNOSIS.
    Retin Cases Brief Rep 2016 Nov 17. Epub 2016 Nov 17.
    *Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; †Department of Ophthalmology, Brazilian Institute of Fight Against Blindness, Assis and Presidente Prudente, São Paulo, Brazil; and ‡Department of Oncology, Hospital Fundação Amaral Carvalho, Jaú, São Paulo, Brazil.
    Purpose: To report a case of bilateral diffuse uveal melanocytic proliferation associated with renal carcinoma and to illustrate the importance of ancillary examinations to early diagnosis and treatment.

    Design: Clinical case report.

    Methods: A 56-year-old man reported a 3-day history of visual impairment and scotoma in the right eye. Read More

    Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood.
    J Dtsch Dermatol Ges 2017 Jan 10;15(1):70-75. Epub 2016 Nov 10.
    Dermatology, Department of -Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
    Background And Objectives: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups.

    Patients And Methods: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome. Read More

    Dermoscopic monitoring of efficacy of ingenol mebutate in the treatment of pigmented and non-pigmented basal cell carcinomas.
    Dermatol Ther 2017 Jan 12;30(1). Epub 2016 Nov 12.
    Department of Dermatology, University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
    Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered the mainstay of therapy, new current pharmacological options are available and focus on tumor eradication, maximizing cosmetic results, and functional capacity. Several studies have recently reported on safety and efficacy of topical ingenol mebutate gel, a derivative of the plant Euphorbia Peplus, used to treat actinic keratosis and superficial basal cell carcinoma. Read More

    Flat choroidal melanoma masquerading as central serous chorioretinopathy.
    Oman J Ophthalmol 2016 Sep-Dec;9(3):174-176
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
    There are several mimickers of choroidal melanoma. We report a patient with recent family stress who developed blurred vision to 20/50 OD and was found to have unilateral central serous chorioretinopathy and a coincidental choroidal nevus. After 1 year without resolution of the subretinal fluid, the patient was referred for our opinion. Read More

    Evaluating the Causes of Freckle and Nevus from the Viewpoint of Iranian Traditional Medicine.
    Iran J Med Sci 2016 May;41(3 Suppl):S67
    Department of Iranian Traditional Medicine' School of Medicine' Shiraz University of Medical Sciences' Shiraz' Iran.
    Background: Freckles are due to an increase in the amount of dark pigments called melanin. These spots are more likely developed on the sun-exposed skin areas like the cheeks, nose, and forehead. Nevus is usually a benign melanocytic tumor and can be congenital or acquired. Read More

    Dysplastic nevi with severe atypia: Long-term outcomes in patients with and without re-excision.
    J Am Acad Dermatol 2017 Feb 9;76(2):244-249. Epub 2016 Nov 9.
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:
    Background: Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited.

    Objective: We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise. Read More

    Agminated blue nevus - Case report.
    An Bras Dermatol 2016 Sep-Oct;91(5):658-660
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Blue nevi are benign melanocytic lesions located in the deeper reticular dermis, consequence of failure of melanocytic migration into the dermal-epidermal junction from the neural crest. Lesions are usually asymptomatic and solitary, but may present in a multiple or agminated (grouped) pattern. The agminated subtype is formed when bluish-pigmented lesions cluster together in a well-defined area. Read More

    Intralymphatic nevus cells in benign nevi.
    Ann Diagn Pathol 2016 Dec 17;25:1-6. Epub 2016 Aug 17.
    Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey. Electronic address:
    The histogenesis of nevus cell aggregates in lymph nodes lesion is controversial, and various hypotheses have been used to explain their origin. One of them is the transport of cells from cutaneous nevi or lesions to lymph nodes, called mechanical transport theory. We investigated in our cases of benign nevi to obtain evidence to substantiate this theory. Read More

    Total reconstruction of giant congenital circumferential nevi of the upper limb using a large pedicle expanded flank flap: A brief report.
    Ann R Coll Surg Engl 2016 Nov 22;98(8):e150-e151. Epub 2016 Sep 22.
    Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , UK.
    Tissue expansion is an invaluable reconstructive strategy after surgical excision of a congenital naevus. However, reducing the number of operations is very important for patients with a giant congenital naevus. We used a large pedicle expanded flank flap to successfully treat a giant circumferential naevus that extended from the left upper arm to the wrist, which also provided excellent contour and colour match. Read More

    Angiomatoid Spitz naevus: novel observations and clues to diagnosis of a rare variant.
    Pathology 2016 Dec 22;48(7):739-742. Epub 2016 Oct 22.
    Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

    Sclerotic Regressing Large Congenital Nevus.
    Pediatr Dermatol 2016 Nov 25;33(6):e366-e367. Epub 2016 Oct 25.
    Second Department of Dermatology, Faculty of Medicine, Aristotle University, Papageorgiou General Hospital, Thessaloniki, Greece.
    Regression of congenital nevi is usually associated with loss of pigment or halo formation. In rare cases, regression is characterized by sclerosis and hair loss. We describe a rare case of a sclerotic hypopigmented large congenital melanocytic nevus in which a localized scleroderma-like reaction process of regression seemed to have started in utero and progressed throughout early childhood. Read More

    Computer Based Melanocytic and Nevus Image Enhancement and Segmentation.
    Biomed Res Int 2016 28;2016:2082589. Epub 2016 Sep 28.
    Department of Computer Engineering, Bahria University, Islamabad, Pakistan.
    Digital dermoscopy aids dermatologists in monitoring potentially cancerous skin lesions. Melanoma is the 5th common form of skin cancer that is rare but the most dangerous. Melanoma is curable if it is detected at an early stage. Read More

    [Nested melanoma].
    Ann Dermatol Venereol 2017 Jan 19;144(1):60-64. Epub 2016 Oct 19.
    Cabinet d'anatomopathologie, SCM DMS, 23, boulevard Président-Franklin-Roosevelt, 33400 Talence, France.
    Background: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype.

    Case Report: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour. Read More

    Drug-induced eruptive melanocytic nevi.
    Expert Opin Drug Metab Toxicol 2017 Mar 21;13(3):293-300. Epub 2016 Oct 21.
    c Dermatology Unit , Second University of Naples , Naples , Italy.
    Introduction: The sudden eruption of melanocytic nevi has been associated with a number of conditions, such as bullous skin diseases, immunodeficiency and immunosuppression. The exact mechanisms leading to the development of eruptive melanocytic nevi are unknown. Areas covered: The aim of this article is to review the literature concerning eruptive melanocytic nevi following the administration of immunosuppressive drugs and other medications. Read More

    [Features of skin graft in pediatric plastic surgery].
    Ann Chir Plast Esthet 2016 Oct 18;61(5):722-731. Epub 2016 Aug 18.
    Service de chirurgie plastique, esthétique et reconstructrice, hôpital Salengro, rue Émile-Laine, 59037 Lille cedex, France.
    Skin graft is a skin tissue fragment transferred from a donor site to a receiving site with a spontaneous revascularization. Basic process of plastic surgery, skin graft known in children, specific, warnings and refinements. It finds its indication in many pediatric cases: integumental diseases (neavus, hamartoma), acute burns and scars, traumatic loss of substance or surgically induced, congenital malformations of the hands and feet, etc. Read More

    [Contribution of the physical and rehabilitation medicine in pediatric plastic surgery].
    Ann Chir Plast Esthet 2016 Oct 4;61(5):589-597. Epub 2016 Aug 4.
    Service de chirurgie plastique, reconstructrice et esthétique, hôpital Roger-Salengro, CHRU de Lille, rue Emile-Laine, 59037 Lille, France.
    Physical, non-painful processes guide the scar reshaping in children in order to prevent growth anomalies due to cutaneous shrinkage. The objective of the surgical treatment, coordinated with the reeducation care, is to improve the physical abilities of the skin, to restore the function and avoid the deformations. Reeducation uses various techniques (i. Read More

    Validation of diagnostic accuracy with whole-slide imaging compared with glass slide review in dermatopathology.
    J Am Acad Dermatol 2016 Dec 11;75(6):1229-1237. Epub 2016 Oct 11.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Division of Dermatopathology and Cutaneous Immunopathology, Department of Dermatology, Mayo Clinic, Rochester, Minnesota. Electronic address:
    Background: Teledermatopathology has evolved from static images to whole slide imaging (WSI), which allows for remote viewing and manipulation of tissue sections. Previous studies of WSI in teledermatopathology predated College of American Pathologists (CAP) telepathology validation guidelines.

    Objective: We conducted a comprehensive retrospective WSI validation study of routine dermatopathology cases, adhering to CAP guidelines. Read More

    Basal Cell Carcinoma of the Umbilicus: A Comprehensive Literature Review.
    Cureus 2016 Sep 7;8(9):e770. Epub 2016 Sep 7.
    Department of Dermatology, University of California, San Diego.
    Basal cell carcinoma (BCC) typically occurs in sun-exposed sites. Only 16 individuals with umbilical BCC have been described in the literature, and the characteristics of patients with umbilical BCC are summarized. PubMed was used to search the following terms: abdomen, basal cell carcinoma, basal cell nevus syndrome, and umbilicus. Read More

    Picosecond pulse duration laser treatment for dermal melanocytosis in Asians : A retrospective review.
    Laser Ther 2016 Jun;25(2):99-104
    Department of Plastic and Reconstructive Surgery, Keio University.
    Background and aims: Recently novel picosecond duration lasers (ps-lasers) have been developed for the treatment of multicolored and recalcitrant tattoos, and safety and efficacy have been reported. We therefore hypothesized that the ps-laser could be an alternative treatment for dermal pigmented lesions and performed a retrospective review to evaluate the efficacy and safety of the ps-laser. Subjects and methods: A retrospective photographic review of 10 patients with dermal pigmented lesions was performed (ages from 4 months to 52 yr), 6 nevus of Ota, 3 ectopic Mongolian spots and 1 Mongolian spots. Read More

    Expanded bi-pedicled "sleeve" flap for reconstruction of the upper extremity after large circumferential nevus excision in children.
    J Plast Reconstr Aesthet Surg 2016 Dec 5;69(12):1676-1682. Epub 2016 Oct 5.
    Department of Plastic, Reconstructive, and Hand Surgery, Hadassah University Medical Center, Jerusalem, Israel.
    Background: Large congenital melanocytic nevi entail significant medical and cosmetic ramifications for patients and families. Reconstruction is a challenging endeavor, especially when the lesion is present on the limbs. The literature describes various methods by which a plastic surgeon can address reconstruction; yet, to date, there has been no series describing a method that provides consistent results with low complication rates. Read More

    [Congenital "kissing" lesions: Nevus or "café au lait" spot?]
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Dec 4;117(6):433-437. Epub 2016 Oct 4.
    Service de chirurgie maxillo-faciale et plastique, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Centre de référence des malformations faciales et de la cavité buccale, MAFACE, AP-HP, 75015 Paris, France; Université Paris Descartes, 75005 Paris, France. Electronic address:
    Introduction: "Café au lait" spots (CLS) are pigmented skin lesions principally located at the trunk and the limbs. Histologically, CLSs consist in an excessive pigmentation of the epidermis, with no risk of malignant transformation. The "kissing" nevus is a rare pigmented congenital nevus affecting both lower and upper eyelids in a mirror layout. Read More

    Paired comparison of the sensitivity and specificity of multispectral digital skin lesion analysis and reflectance confocal microscopy in the detection of melanoma in vivo: A cross-sectional study.
    J Am Acad Dermatol 2016 Dec 29;75(6):1187-1192.e2. Epub 2016 Sep 29.
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.
    Background: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM.

    Objective: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients). Read More

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