11,423 results match your criteria Halo Nevus

[The risks of tanning with the Barbie drug].

Ned Tijdschr Geneeskd 2022 May 19;166. Epub 2022 May 19.

Groene Hart Ziekenhuis, afd. Interne Geneeskunde, Gouda.

Background: Melanotan II, also known as 'Barbie drugs', can be purchased over the internet and in gyms to facilitate sunless tanning. The purchased product is a alpha-melanocyte-stimulating hormone (α-MSH) analogue, which stimulates the production of eumelanin to get skin pigmentation. However, previous research showed that Melanotan supports the development of new pigmented and dysplastic naevi. Read More

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Hip dislocation based on Developmental Dysplasia of the Hip (DDH) in a patient with Giant Congenital Melanocytic Nevus (GCMN): A rare coexistence.

M Kaya H H Muratli

Niger J Clin Pract 2022 Jun;25(6):960-963

Department of Orthopedics and Traumatology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.

Giant congenital melanocytic nevus (GCMN) is a rare congenital benign neoplasm with the potential to become malignant. Various extracutaneous malformations may accompany GCMN. Acetabular dysplasia accompanying GCMN was described in previous studies. Read More

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Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915

Discipline of Ophthalmology, Department of Surgery II, Discipline of Anatomy and Embryology, Department of Morphofunctional Sciences I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Background: Conjunctival pigmented neoplasia can be benign, premalignant or malignant tumors. Our study aims to establish the epidemiological, gross morphological and immunohistopathological features of the conjunctival pigmented lesions in pediatric and adolescent patients (<18 years), to establish an accurate diagnosis.

Patients, Material And Methods: This is a retrospective case series study conducted within two Ophthalmology Clinics from Iaşi, Romania, on seven pediatric and adolescent patients. Read More

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Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.

Comput Math Methods Med 2022 28;2022:9726181. Epub 2022 May 28.

School of Nursing, Binzhou Medical University, Binzhou, 256603 Shandong, China.

The objective of this study was to explore the image classification and case characteristics of pigmented nevus (PN) diagnosed by dermoscopy under deep learning. 268 patients were included as the research objects and they were randomly divided into observation group ( = 134) and control group ( = 134). Image recognition algorithm was used for feature extraction, segmentation, and classification of dermoscopic images, and the image recognition and classification algorithm were studied as the performance and accuracy of fusion classifier were compared. Read More

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At-Home Treatment of Pigmented Lesions With a Zinc Chloride Preparation.

Cutis 2022 02;109(2):E25-E26

Alamance Dermatology, Burlington, North Carolina.

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February 2022

Simple Congenital Hamartoma of Retinal Pigment Epithelium.

J Coll Physicians Surg Pak 2022 Apr;32(4):S31-S33

Department of Ophthalmology, Rashid Latif Medical College, Lahore, Pakistan.

A 45-year female presented in the Outpatient Department of a tertiary care hospital of Lahore with dimness of vision in the right eye. Her history revealed that the patient had noticed decreased vision since her childhood. Fundus examination revealed a jet-black slightly raised lesion about the size of ¼-disc diameter, located in the centre of macula. Read More

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DDR2 mutation in a spilus-type giant congenital melanocytic nevus.

J Eur Acad Dermatol Venereol 2022 May 27. Epub 2022 May 27.

Department of Dermatology, Puerta del Mar University Hospital, 2ª planta. Avenida Ana de Viya 21, 11009, Cádiz, Spain.

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A case of proliferative nodule arising within blue nevus.

Clin Ter 2022 May;173(3):214-216

Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.

Abstract: Blue nevi are a heterogeneous group of lesions that can display a variety of different clinicopathological characteristics. Although attempts are made to classify each lesion into defined subtypes, there can be overlap between the subtypes. The clinical , dermoscopic and histolopathologic features of a case of proliferative nodule arising within blue nevus is discussed. Read More

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Dermoscopic features of eyelid margin tumors: A single-center retrospective study.

J Dermatol 2022 May 24. Epub 2022 May 24.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Despite rapid growth in the significance of dermoscopy in dermatological oncology, relatively little is yet known about the dermoscopic patterns of eyelid margin tumors. The aim of the study was to analyze the dermoscopic features of eyelid margin tumors. This was a retrospective, single-center, consecutive study which included clinical and dermoscopic analysis of eyelid margin tumors diagnosed at the Department of Dermatology, Venereology and Allergology at the Medical University of Gdańsk from 1 June 2016 to 31 December 2020. Read More

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Dysplastic nevi and melanoma: microRNAs tell a divergent story.

Pathol Res Pract 2022 Jul 14;235:153942. Epub 2022 May 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna 40100, Italy; Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40100, Italy.

Background: dysplastic nevi (DN) share some clinical and histological features with melanoma and have been considered intermediate lesions toward malignant transformation. However, scientific evidence of DN representing melanoma precursors is still incomplete, and many observations pointed toward their being a distinct biological entity. The current definition of DN is also confusing and the practical consequence of this uncertainty is the excessive excision of DN with severe atypia. Read More

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Oncogenic properties via MAPK signaling of the SOX5-RAF1 fusion gene identified in a wild-type NRAS/BRAF giant congenital nevus.

Pigment Cell Melanoma Res 2022 Jul 31;35(4):450-460. Epub 2022 May 31.

Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

We recently reported an RAF rearrangement without NRAS or BRAF mutations in lesions from Giant Congenital Melanocytic Nevi (CMN). The new gene fusion involves the 5'-end of the promoter-containing N terminus of the SOX5 gene fused to exons 7-16 of the 3'-end of RAF1 gene leading to a SOX5-RAF1 fusion transcript which loses the auto-inhibitory CR1 domain but retains the complete in-frame coding sequence for the C-Terminal kinase domain of the RAF1. Stable expression of SOX5-RAF1 fusion induced growth factor-independent cell growth in murine hematopoietic Ba/F3 cells and melan-a immortalized melanocytes. Read More

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Expression of endoglin, CD105, in conjunctival melanocytic nevi: Is it suspicious like in thyroidology? Oculi plus vident quam oculus?

Rev Assoc Med Bras (1992) 2022 May;68(5):680-684

General Hospital Novi Pazar, Department of Surgery - Novi Pazar, Serbia.

Objective: The aim of this study was to evaluate the expression of endoglin and its correlation with histopathological and clinical findings in conjunctival nevi.

Methods: The study included archival formalin-fixed, paraffin-embedded tissue sections of 44 patients with conjunctival nevi. Immunohistochemical staining for CD105 had been performed with monoclonal mouse antihuman CD105 antibodies. Read More

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Acquired Compound Melanocytic Nevus on the Palate of a Child: Report of a Case.

J Oral Maxillofac Res 2022 Jan-Mar;13(1):e5. Epub 2022 Mar 31.

Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of AthensGreece.

Background: Oral melanocytic nevi are relatively rare in comparison to their cutaneous counterparts. The aim of this manuscript is to present a case of acquired compound oral melanocytic nevi on the hard palatal mucosa of a child.

Methods: A 5-year-old female girl was referred for evaluation of a pigmented lesion on the hard palate. Read More

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The first case of Chinese phacomatosis pigmentokeratotica diagnosed by a missense HRAS mosaicism.

J Dermatol 2022 May 13. Epub 2022 May 13.

Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Phacomatosis pigmentokeratotica (PPK) is a rare epidermal nevus (EN) syndrome, featured by co-occurrence of speckled lentiginous nevus (SLN) and nevus sebaceous (NS). The underlying mechanism has not been clarified. Pathogenic mutations in HRAS, KRAS and BRAF gene are recently recognized as the genetic cause of PPK. Read More

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Texture Analysis in Diagnosing Skin Pigmented Lesions in Normal and Polarized Light-A Preliminary Report.

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Maxillofacial Surgery, Medical University of Lodz, 113 S. Zeromski Street, 90-549 Lodz, Poland.

The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis of pixel patterns of a digital image. Read More

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Tetraspanin CD9 Expression Predicts Sentinel Node Status in Patients with Cutaneous Melanoma.

Int J Mol Sci 2022 Apr 26;23(9). Epub 2022 Apr 26.

Clinica Dermatologica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 60126 Ancona, Italy.

The tetraspanin CD9 is considered a metastasis suppressor in many cancers, however its role is highly debated. Currently, little is known about CD9 prognostic value in cutaneous melanoma. Our aim was to analyse CD9 expression in melanocytic nevi and primary cutaneous melanomas through immunohistochemistry and immunofluorescence approaches to determine its correlation with invasiveness and metastatic potential. Read More

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Topical therapy for regression and melanoma prevention of congenital giant nevi.

Cell 2022 Jun 12;185(12):2071-2085.e12. Epub 2022 May 12.

Department of Translational Molecular Medicine, Saint John's Cancer Institute Providence Health and System, Santa Monica, CA 90404.

Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80% of the body surface. Their most dangerous consequence is progression to melanoma. This risk often triggers preemptive extensive surgical excisions in childhood, producing severe lifelong challenges. Read More

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Determination of CCL2 / MCP-1 levels in the serum of children with melanocytic nevus in the postoperative period after using different methods of surgical treatment.

Acta Biomed 2022 05 11;93(2):e2021464. Epub 2022 May 11.

Department of Microbiology, National Pirogov Memorial Medical University, Pirogov, 56, Vinnytsia, Ukraine,.

To date, there are many methods and ways to remove pigmented skin tumors, which have their own indications and contraindications for use, early or late complications.The aim of the study was to determine the level of CCL2 / MCP-1 in the serum of patients with melanocyte skin nevi in the postoperative period with different methods of their removal.Materials and methods of research. Read More

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Dermoscopic changes to a melanocytic naevi from intense pulse light therapy.

BMJ Case Rep 2022 05 11;15(5). Epub 2022 May 11.

Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

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Melanoma developing in a nevoid melanocytoma with myxoid changes: a case report.

Int J Clin Exp Pathol 2022 15;15(4):201-205. Epub 2022 Apr 15.

Department of Dermatology, Wayne State University MI, USA.

Nevoid and myxoid melanoma are rare variants of melanoma; association of the two is a unique finding. Nevoid melanoma is characterized by morphologic resemblance to a nevus, whereas myxoid melanoma demonstrates a basophilic mucinous matrix. We present an atypical case of a melanoma progressing from a nevoid melanocytoma with myxoid changes. Read More

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Atypical Presentation of Halo Nevus over Eyelid with Poliosis: A Dermatoscopic Perspective.

Int J Trichology 2022 Mar-Apr;14(2):68-70. Epub 2022 Apr 4.

Department of Dermatology, Shree Krishna Hospital, Karamsad, Gujarat, India.

Halo nevus (HN) is benign skin condition with a central melanocytic nevus, surrounded by an area or halo of depigmentation. It is the result of immunological response of the body toward the nevus, which destroys the melanocytes in surrounding skin, leading to the depigmented halo. An increased frequency of HN in patients with vitiligo is observed. Read More

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Nevus Psiloliparus: Case Series.

Actas Dermosifiliogr 2022 03 9;113(3):319-321. Epub 2022 Feb 9.

Departamento de Dermatología, Hospital Humberto Notti, Guaymallén, Mendoza, Argentina.

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Pigmented Papule With a Starburst Pattern on Dermoscopy.

Actas Dermosifiliogr 2022 03 14;113(3):301-302. Epub 2021 Sep 14.

Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.

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Examination of Subungual Hematomas and Subungual Melanocytic Lesions by Using Optical Coherence Tomography and Dermoscopy.

Dermatology 2022 May 4:1-9. Epub 2022 May 4.

Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Introduction: Examination of subungual pigmented lesions is sometimes a diagnostic challenge for clinicians.

Objectives: The study was aimed to investigate characteristic patterns in optical coherence tomography (OCT) of subungual hematomas and determine distinctive features that can differentiate them from subungual melanocytic lesions.

Methods: VivoSight® (Michelson Diagnostics, Maidstone, UK) was used to examine 71 subungual hematomas and 11 subungual melanocytic lesions in 69 patients (18 female and 51 male patients). Read More

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The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects.

Am J Dermatopathol 2022 May 3. Epub 2022 May 3.

Department of Stomatology, Dental School, University of Sao Paulo, Sao Paulo, Brazil; and.

Abstract: Oral pigmentations are a heterogeneous group and can be the result of physiological activity of oral mucosal melanocytes, secondary to exogenous causes, associated with systemic or local diseases, or due to proliferative activity of melanocytes. Their diagnosis is critical because these lesions can be markers of internal diseases or, in the case of melanocytic proliferative processes, they may represent a malignant neoplasm. In the past decade, the use of reflectance confocal microscopy, a noninvasive imaging tool, has aided the analysis of such lesions, but the establishment of firm criteria in their evaluation is still lacking. Read More

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Phakomatosis pigmentovascularis type Ⅲa mainly manifested by zosteriform nevus spilus: A case report with dermoscopic features.

Photodiagnosis Photodyn Ther 2022 Jun 28;38:102890. Epub 2022 Apr 28.

Department of Dermatology, Shanghai Pudong New Area People's Hospital, Shanghai 201299, China. Electronic address:

A case of phakomatosis pigmentovascularis (PPV) type III a with a zosteriform distribution of nevus spilus as the main manifestation was reported. A 41-year-old man was born with a zosteriform distribution of pigmented rash on the left half-body, namely upper limb, shoulder and back. Physical examination revealed light brown pigments in a giant zosteriform distribution on the extensor side of the left upper limb and the left shoulder and back, with scattered brown spots and patches of variant sizes on the surface, which are consistent with the appearance of nevus spilus (NS). Read More

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Blue nevi of the palpebral conjunctiva: report of 2 cases and review of literature.

Orbit 2022 Apr 28:1-8. Epub 2022 Apr 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Purpose: To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva.

Methods: Report of two cases and literature review.

Results: We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Read More

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Nevus Comedonicus with Epidermolytic Hyperkeratosis: A Case Report.

Iran J Pathol 2022 8;17(2):234-237. Epub 2022 Mar 8.

Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Nevus comedonicus (NC) is a rare developmental anomaly of the folliculosebaceous apparatus, which appears as numerous dilated papules containing firm, darkly pigmented, horny plugs. It appears shortly after birth and mostly before the age of 10; however, late-onset cases have been reported. There is no gender or racial predilection. Read More

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The Morpho-Molecular Landscape of Spitz Neoplasms.

Int J Mol Sci 2022 Apr 11;23(8). Epub 2022 Apr 11.

Pathological Anatomy Unit, University Hospital of Padua, 35121 Padua, Italy.

Spitz neoplasms are a heterogeneous group of melanocytic proliferations with a great variability in the histological characteristics and in the biological behavior. Thanks to recent discoveries, the morpho-molecular landscape of Spitz lineage is becoming clearer, with the identification of subtypes with recurrent features thus providing the basis for a more solid and precise tumor classification. Indeed, specific mutually exclusive driver molecular events, namely or mutations, copy number gains of 11p, and fusions involving and genes, correlate with distinctive histological features. Read More

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The spectrum of melanocytic nevi and their clinical implications.

J Dtsch Dermatol Ges 2022 04;20(4):483-504

Institute of Pathology, Medical University Hospital Innsbruck, Austria.

The magnitude of the topic of melanocytic nevi (MN) is directly related to its relevance in everyday clinical work. The different MN have different prognostic significance in regard to comorbidity and possible risk of transformation. In addition to the criteria of the ABCDE rule, relevant criteria in the assessment of an MN are the time of occurrence, the growth tendency, the distribution and the comparison with other MN of the respective individual. Read More

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