10,008 results match your criteria Halo Nevus


Treatment of halo naevus with the topical Janus kinase inhibitor tofacitinib 1.5.

Authors:
W T Hu F Q Lin A E Xu

Clin Exp Dermatol 2018 Jun 6. Epub 2018 Jun 6.

Department of Dermatology, Third People's Hospital of Hangzhou affiliated to Zhejiang Chinese Medical University, Hangzhou, 310053, China.

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June 2018
1 Read

Metastatic Blue Nevus-Like Melanoma Detected by Liquid-Based Catheterized Urine Cytology.

Ann Dermatol 2018 Jun 23;30(3):356-360. Epub 2018 Apr 23.

Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

Primary or metastatic malignant melanoma can mimic benign blue nevus in rare cases, making the diagnosis challenging. Herein, we report an exceptionally rare case of blue nevus-like melanoma and its blue nevus-like metastasis which was detected by catheterized urine cytology. The patient presented with blue-colored papuloplaques on his temple which were diagnosed as blue nevus-like melanoma on punch biopsies. Read More

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A 10-year delayed diagnosis of blue rubber bleb nevus syndrome characterized by refractory iron-deficiency anemia: A case report and literature review.

Medicine (Baltimore) 2018 Jun;97(22):e10873

Department of Pediatrics, West China Second University Hospital.

Rationale: Blue rubber bleb nevus syndrome (BRBNS) is a rare vascular disorder consisting of multifocal venous malformations. Delayed diagnosis or misdiagnosis frequently occurs in patients without typical cutaneous lesions or gastrointestinal bleeding symptoms. This article reports a 10-year case of delayed diagnosis of BRBNS detected by capsule endoscopy. Read More

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[Focus on clinical and pathological management of conjunctival melanocytic tumors].

Ann Pathol 2018 May 23. Epub 2018 May 23.

Laboratoire de pathologie clinique et expérimentale, pavillon J, hôpital Pasteur, CHU de Nice, 30, voie Romaine, CS 51069, 06001 Nice cedex 1, France; Institute of research on cancer and aging de Nice (IRCAN), Inserm U1081/CNRS UMR7284, UFR de médecine, 28, avenue Valombrose, 06107 Nice cedex 2, France; FHU OncoAge Nice, 30, avenue de la voie Romaine, CS 51069, 06001 Nice cedex 1, France.

Conjunctival-pigmented tumors are rare, but they are one of the most commonly encountered by the pathologist working with the department of ophthalmology. Nevus and melanoma can be encountered and have some histological difference compared to their cutaneous counterpart. Primary acquired melanosis (PAM) is a conjunctival specific entity. Read More

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Genomic Fusions in Pigmented Spindle Cell Nevus of Reed.

Am J Surg Pathol 2018 May 22. Epub 2018 May 22.

Department of Dermatology, Feinberg School of Medicine, Northwestern University.

Recent molecular studies of spitzoid neoplasms have identified mutually exclusive kinase fusions involving ROS1, ALK, RET, BRAF, NTRK1, MET, and NTRK3 as early initiating genomic events. Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure, and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant role in these lesions. Read More

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Dermoscopy of a Spark's nevus.

Dermatol Pract Concept 2018 Apr 30;8(2):126-128. Epub 2018 Apr 30.

Dermatology Unit, Galliera Hospital, Genoa, Italy.

Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes. Read More

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Histologic mimics of malignant melanoma.

Singapore Med J 2018 May 18. Epub 2018 May 18.

Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY, USA.

Although spongiotic (eczematous), psoriatic and cutaneous skin infections are among the most common dermatology consultations, melanocytic lesions - including the different types of nevi and melanomas - are among those that cause a great deal of concern and stress to patients and their clinicians. A diagnosis of benign melanocytic nevus carries a very good prognosis. However, a diagnosis of melanoma might imply more aggressive treatment, lifelong surveillance and a worse prognosis. Read More

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May 2018
1 Read

Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall.

Pathol Res Pract 2018 Jun 11;214(6):821-825. Epub 2018 May 11.

Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors. Read More

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June 2018
3 Reads
1.56 Impact Factor

Management of resistant halo nevi.

J Cosmet Laser Ther 2018 May 9:1-4. Epub 2018 May 9.

a Department of Dermatology and Venereology, Faculty of Medicine , Minia University , Minia , Egypt.

Background: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo.

Objectives: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo. Read More

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Orofacial signs and dental abnormalities in patients with Mulvihill-Smith syndrome: A literature review on this rare progeroid pathology.

Medicine (Baltimore) 2018 May;97(18):e0656

Department of Oral Surgery and Implantology, Catholic University of Sacred Heart of Rome, Gemelli Hospital.

Background: Mulvihill-Smith syndrome is a rare sporadic condition that was first recognized in 1975. A total of 11 cases have been described in the literature. The aim of this study was to describe the orofacial signs and dental anomalies, their frequency, and the relationship between Mulvihill-Smith syndrome and other progeroid syndromes via a review of the literature. Read More

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Perinevoid alopecia: A case report and literature review.

Br J Dermatol 2018 Apr 28. Epub 2018 Apr 28.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.

Perinevoid alopecia is a rare variant of alopecia areata (AA) associated with a central pigmented nevus, and its pathogenesis is unclear owing to its rarity . A 22-year-old Japanese woman presented with two hairless patches around nevi on the right side of the vertex (Fig. 1a) and back of the scalp (Fig. Read More

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Orbital melanocytoma: When a tumor becomes a relieving surprise.

Am J Ophthalmol Case Rep 2018 Jun 24;10:124-127. Epub 2018 Feb 24.

Ophthalmology Department, Kasr Al Ainy school of medicine, Cairo University, Cairo, Egypt.

Purpose: Melanocytomas are rare pigmented tumors that arise form melanocytes and have been reported in the central nervous system. Orbital melanocytomas "also known as blue nevus" are rarely reported. The occurrence of choroidal melanoma and orbital melanocytomas has never been described. Read More

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Solitary pigmented lesions in oral mucosa in Latin American children: A case series.

Pediatr Dermatol 2018 May 24;35(3):374-377. Epub 2018 Mar 24.

Department of Pathology and Oral Medicine, School of Dentistry, Oral Medicine Clinic, Universidad de Chile, Santiago, Chile.

Background: A variety of local and systemic processes caused exogenous and endogenous pigmentation of the oral mucosa. Solitary melanotic pigmentation is rare, hence the scarce number of studies in children and adolescents.

Methods: Clinical and histopathologic features of 10 Latin American children with solitary pigmented lesions of the oral mucosa were reviewed. Read More

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May 2018
1 Read

Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course.

Ophthalmology 2018 Mar 15. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

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March 2018
2 Reads

Prevalence of choroidal nevus and retinal pigment epithelial alterations in vitiligo patients.

Graefes Arch Clin Exp Ophthalmol 2018 May 16;256(5):927-933. Epub 2018 Mar 16.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Weizman 6, 6423906, Tel Aviv, Israel.

Purpose: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF).

Methods: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Read More

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May 2018
3 Reads

[Bean's syndrome in children: about two cases].

Pan Afr Med J 2017 4;28:102. Epub 2017 Oct 4.

Service des Urgences Chirurgicales Pédiatriques, CHU Ibn Sina, Faculté de Médecine Mohammed V, Rabat, Maroc.

Diffuse angiomatosis or Bean's syndrome is a rare disease characterized by venous malformations mainly involving the skin and the digestive tract which can result in hemorrhage of variable severity. This study reports the case of two children aged 5 and 9 and a half years respectively with diffuse angiomatosis who had been treated in the Department of Emergency Paediatric Surgery over the years. The diagnosis was based on rectal bleeding and/or melenas causing severe anemia requiring regular transfusions in both patients as well as skin angiomas occurrence at the level of the limbs. Read More

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Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions.

Graefes Arch Clin Exp Ophthalmol 2018 Apr 28;256(4):643-649. Epub 2018 Feb 28.

Department of Ophthalmology, Jacobs Retina Center at the Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.

Purpose: Our purpose was to compare the characteristics of the retinal and choroidal lesions including choroidal nevus, choroidal melanoma and congenital hypertrophy of the retina pigment epithelium using conventional color fundus photography (CFP) and multicolor imaging (MCI).

Methods: The paired images of patients with retinal or choroidal lesions were assessed for the visibility of lesion's border, halo and drusen using a grading scale (0-2). The area of the lesion was measured on both imaging modalities. Read More

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Medium Sized Congenital Melanocytic Nevus with Suspected Progression to Melanoma during Pregnancy: What's the Best for the Patient?

Open Access Maced J Med Sci 2018 Jan 13;6(1):143-145. Epub 2018 Jan 13.

University G. Marconi of Rome - Dermatology and Venereology, Rome, Italy.

Background: Congenital melanocytic nevi (CMN) are pigmented skin lesions usually present at birth. Rare varieties can develop and become clinically very large. Although they are benign nevomelanocytic neoplasms, all CMN may be precursors of the melanoma, regardless of their size. Read More

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January 2018

Sirolimus alternative to blood transfusion as a life saver in blue rubber bleb nevus syndrome: A case report.

Medicine (Baltimore) 2018 Feb;97(8):e9453

Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.

Rationale: Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Read More

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February 2018
6 Reads

Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors.

Virchows Arch 2018 Mar 21;472(3):469-476. Epub 2018 Feb 21.

Département de Biopathologie, Centre Leon Bérard, Lyon, France.

The current classification of melanocytic tumors includes clinical, pathological, and molecular data. A subset of lesions remains difficult to classify according to these complex multilayer schemes. We report two cases of deeply infiltrating melanomas with a sclerosing background. Read More

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March 2018
4 Reads

Conjunctival melanocytic naevus: Diagnostic value of anterior segment optical coherence tomography and ultrasound biomicroscopy.

PLoS One 2018 14;13(2):e0192908. Epub 2018 Feb 14.

University of Szeged, Department of Ophthalmology, Szeged, Hungary.

Purpose: Conjunctival naevi are the most frequently diagnosed primary melanocytic lesions of the conjunctiva. The clinical manifestations are greatly variable which may result in diagnostic difficulties and differential diagnostic confusions. Therefore aims of the present study were: 1) to assess the morphologic features of conjunctival naevi; 2) to delineate the anterior segment optical coherence tomography (AS-OCT) characteristics of these lesions; 3) to compare AS-OCT and ultrasound biomicroscopy (UBM) as diagnostic tools in these alterations and 4) to correlate histological results with the AS-OCT pictures in case of surgically excised naevi. Read More

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Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation.

Lasers Med Sci 2018 Feb 9. Epub 2018 Feb 9.

Dermatology Department, Laser Unit, Hospital Universitario Ramón y Cajal, Ctra Colmenar Viejo Km 9,100, 28034, Madrid, Spain.

The novel picosecond lasers, initially developed for faster tattoo removal, have also shown great efficacy in endogenous pigmentary disorders. To describe the efficacy and safety profile of an alexandrite (755-nm) picosecond laser in a wide range of pigmented flat and elevated cutaneous lesions. A retrospective study was performed in which we collected all the clinical images of patients treated with the 755-nm alexandrite picosecond laser for 12 months (November 2016-November 2017). Read More

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February 2018
5 Reads

Lacrimal Caruncle Nevus with Papilloma.

Case Rep Ophthalmol 2017 Sep-Dec;8(3):535-538. Epub 2017 Dec 5.

Department of Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Nagakute, Japan.

Purpose: The aim of this article is to report a case of lacrimal caruncle nevus with papilloma.

Methods: This is a case report of a 39-year-old female with a progressively enlarging pigmented lesion on the left lacrimal caruncle. She had been aware of a raised whitish wart on the top of this pigmented lesion for several months before her initial visit. Read More

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December 2017
1 Read

Commentary on Atypical Melanocytic Proliferations.

Authors:
Clay J Cockerell

Dermatol Surg 2018 02;44(2):175-176

Division of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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February 2018
1 Read

A quantitative comparison between SOX10 and MART-1 immunostaining to detect melanocytic hyperplasia in chronically sun-damaged skin.

J Cutan Pathol 2018 Apr 15;45(4):263-268. Epub 2018 Feb 15.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut.

Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun-damaged skin is challenging. The first-line immunostain is usually MART-1/Melan-A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART-1 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2-mm diameter fields in pigmented actinic keratosis (n = 16), lichenoid keratosis (n = 7), junctional melanocytic nevus (n = 6), keratosis with atypical melanocytic proliferation (n = 17) and MIS (n = 10). Read More

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April 2018
5 Reads

An alternative strategy treated giant congenital melanocytic nevi with epidermis and superficial dermis of the lesions.

Medicine (Baltimore) 2018 Jan;97(4):e9725

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Giant congenital melanocytic nevi (GCMN) are defined as rare pigmented lesions that are believed to form between weeks 9 and 20 of gestation. It is difficult to reconstruct large defects after the removal of the lesions and it has posed a great challenge to the plastic surgeon and dermatologist.Given all those difficulty reconstructing the defects, we try to explore an alternative way to resurfacing the defect after removal of GCMN. Read More

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January 2018
7 Reads

Clinical profile of 300 men with facial hypermelanosis.

J Dermatol Case Rep 2017 Dec 1;11(2):20-24. Epub 2017 Dec 1.

Department of Dermatology, Venereology & Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda)-176001 (Himachal Pradesh), India.

Background: Facial hypermelanosis is a significant cause of cosmetic disfigurement, social embarrassment and psychological morbidity affecting quality of life.

Objective: To study clinicoepidemlogic patterns of facial hypermelanoses among men.

Material And Methods: Medical records of all adult males presenting with facial hypermelanoses were analyzed for this retrospective cross sectional study for demographic details, duration, cosmetic usage, sun exposure, drug intake, infections, systemic or cutaneous diseases, and family history of hypermelanotic dermatosis. Read More

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December 2017
1 Read

Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients.

An Bras Dermatol 2017 Nov-Dec;92(6):811-815

Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: The onset of vitiligo during childhood is common. Limited data exist that compare the clinical associations of prepubertal and postpubertal vitiligo in Arabs.

Objective: To compare the clinical profile of pre and postpubertal onset vitiligo. Read More

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April 2018
2 Reads

A Rare Cause of Chronic Anemia and Recurrent Bowel Obstruction.

Gastroenterology 2018 Feb 18;154(3):e4-e7. Epub 2018 Jan 18.

Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

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February 2018
1 Read

A Case of Adenocarcinoma of the Retinal Pigment Epithelium: An Immunohistochemical and Electron Microscopic Study.

Ocul Oncol Pathol 2017 Dec 19;4(1):38-43. Epub 2017 Jul 19.

Department of Ophthalmology, Kansai Medical University, Osaka, Japan.

Purpose: Retinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma.

Case: A 36-year-old male was referred to our clinic because of floaters in his left eye. Read More

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December 2017
2 Reads

[Phakomatosis pigmentovascularis cesioflammea: a case report].

Arch Argent Pediatr 2018 Feb;116(1):e121-e124

Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. J. P. Garrahan", Ciudad Autónoma de Buenos Aires.

Phakomatosis pigmentovascularis (PPV) is a syndrome characterized by the association of a vascular nevus with a congenital pigmented lesion (epidermal nevus, nevus spilus, and dermal melanocytosis). There are different types of PPV according to the pigmentary nevus associated with the vascular malformation. Patients may present only the cutaneous condition or have systemic manifestations, among them, trauma, neurological and ophthalmological disorders. Read More

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February 2018
2 Reads

Dermoscopic Patterns of Spitz Nevi-Reply.

JAMA 2018 01;319(2):194

Department of Dermatology, Peking Union Medical College Hospital, Beijing, China.

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January 2018
1 Read

Dermoscopic Patterns of Spitz Nevi.

JAMA 2018 01;319(2):194

Private practice, Huntingdon Valley, Pennsylvania.

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January 2018
2 Reads

Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features.

Pediatr Dermatol 2018 Mar 4;35(2):e99-e102. Epub 2018 Jan 4.

Department of Dermatology, School of Medicine & Health Sciences, George Washington University, Washington, DC, USA.

Acral pigmented Spitz nevi are seldom reported in the literature. We report a new case on the palm of a 4-year-old girl that demonstrated correlation between features observed on dermoscopy and reflectance confocal microscopy (RCM). Histopathology revealed a benign intraepidermal Spitz nevus with transepidermal elimination of melanocytes that showed on RCM as focal atypical bright cells concerning for malignancy. Read More

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March 2018
4 Reads

Using Tissue Expanders as a Choice for the Treatment of Congenital Facial Nevus in the Young Child.

Eur J Pediatr Surg 2018 Feb 2;28(1):105-108. Epub 2018 Jan 2.

Division of Vascular Anomalies, Department of Pediatric Surgery, La Paz Children's Hospital, Madrid, Spain.

Objective:  One of the principal objectives in treatment of facial nevus is to minimize psychological damage and encourage the child's schooling by the best possible cosmetic result. There are several therapeutic techniques: grafts, flaps, dermal regenerator, and tissue expanders.

Materials And Methods:  We reviewed 10 patients with facial nevus higher than 10 cm treated in the past 8 years. Read More

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February 2018
6 Reads

Kissing nevus of the penis: a case report and dermatoscopic findings.

An Bras Dermatol 2017 ;92(5 Suppl 1):95-97

Department of Dermatology, Faculdade de Medicina da Universidade do Oeste Paulista (Unoeste) - Presidente Prudente - SP, Brazil.

Divided nevus, also known as kissing nevus, is a rare variant of congenital melanocytic nevi in which there are two adjacent nevi in areas of the body that undergo embryonic cleavage. The original description of this type of lesion was on the eyelid. The location on the penis is even rarer, with only 17 case reports in the literature so far, and only one of them described the dermoscopic findings. Read More

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March 2018
2 Reads

Blue nevus with satellitosis: case report and literature review.

An Bras Dermatol 2017 ;92(5 Suppl 1):30-33

Private practice - Tubarão (SC), Brazil.

Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. Read More

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March 2018
5 Reads

Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.

Rom J Morphol Embryol 2017 ;58(3):739-747

Department of Neurosurgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

Aim: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, "Prof. Read More

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January 2017
5 Reads

Pigmented Kamino bodies: a little-known histological finding. Prevalence in 19 cases of Reed nevus.

An Bras Dermatol 2017 May-Jun;92(3):379-382

Laboratory of Medical Investigation in Mycologia, Faculdade de Medicina, Universidade de São Paulo (LIM 53, FMUSP), São Paulo, SP, Brazil.

The present study aimed to determine the prevalence of Kamino bodies in Reed nevus, since most studies to date show conflicting data on this issue. This was a retrospective observational study, in which the histopathology of 19 Reed nevus lesions were reviewed. The slides were stained by hematoxylin and eosin and periodic acid-Schiff, with a special focus placed on the identification of Kamino bodies. Read More

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January 2018
4 Reads

Histopathological diagnosis of small melanocytic lesions suspicious for malignant melanoma.

An Bras Dermatol 2017 May-Jun;92(3):375-378

Department of Pathology - School of Medicine at Universidade Federal do Rio de Janeiro (UFRJ) - Rio de Janeiro (RJ), Brazil.

The concern about malignant skin neoplasms leads to the excision of smaller lesions. This study on small melanocytic lesions aims to evaluate the range of possible histopathological diagnoses, describe histopathological aspects, and assess the usefulness of serial histological sections. We performed a cross-sectional descriptive histopathological study examining 76 pigmented skin lesions up to 6 mm in diameter. Read More

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January 2018
2 Reads

Dermoscopic patterns of melanocytic nevi in children and adolescents: a cross-sectional study.

An Bras Dermatol 2017 May-Jun;92(3):340-344

Dermatology Outpatient Clinic of the Universidade Federal de São Paulo (EPM-UNIFESP) - São Paulo (SP), Brazil.

Background: Childhood is a dynamic period regarding nevogenesis. Dermoscopy is a noninvasive technique, recommended for the evaluation of pigmented cutaneous lesions.

Objectives: The purpose of this study was to describe the structures and dermoscopic patterns of melanocytic nevi observed in children and adolescents. Read More

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January 2018
4 Reads

Evaluating melanocytic lesions with single nucleotide polymorphism (SNP) chromosomal microarray.

Exp Mol Pathol 2017 12 21;103(3):279-287. Epub 2017 Nov 21.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States. Electronic address:

Histopathology is the gold standard for diagnosing melanocytic lesions; however, distinguishing benign versus malignant is not always clear histologically. Single nucleotide polymorphism (SNP) microarray analysis may help in making a definitive diagnosis. Here, we share our experience with the Oncoscan FFPE Assay and demonstrate its diagnostic utility in the context of ambiguous melanocytic lesions. Read More

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December 2017
5 Reads

Nevi and lasers: Practical considerations.

Lasers Surg Med 2018 Jan 21;50(1):7-9. Epub 2017 Nov 21.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Lasers are increasingly used for elective ablation of melanocytic nevi (MN). However, the associated risks of treating MN with lasers are debated and not well studied. Theoretical risks include inadvertently treating a melanoma mistaken for a nevus, the inability to remove all nevus cells and the possibility for residual cells to undergo malignant transformation, and the difficulty in clinically monitoring the remnant nevus for melanoma progression. Read More

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January 2018
1 Read

Pigmented Spindle Cell Nevus of Reed of the Eyelid.

Ocul Oncol Pathol 2017 Sep 27;3(3):176-180. Epub 2017 Jan 27.

Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Tufts University, Boston, Massachusetts, USA.

Purpose: To report the clinical, pathological, and immunohistochemical features of the first pigmented spindle cell nevus (PSCN) of Reed documented to have appeared in the eyelid.

Methods: The findings of clinical and histopathological examination are presented, along with differential diagnoses and a review of the pertinent literature.

Case: A 3-year-old boy presented with a rapidly growing, heavily pigmented left lower lid papule raising the concern of malignancy, warranting excisional biopsy. Read More

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September 2017
5 Reads

Factors Associated with Development of Vitiligo in Patients with Halo Nevus.

Chin Med J (Engl) 2017 Nov;130(22):2703-2708

Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Background: Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.

Methods: We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital of Sun Yat-sen University between January 2011 and December 2016. Read More

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November 2017
8 Reads

Role of amniotic membrane and full-thickness skin graft in reconstruction of kissing nevus of eyelids.

Indian J Ophthalmol 2017 Nov;65(11):1219-1221

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 20-year-old girl presented with a large pigmented lesion over the temporal aspect of left lateral canthus involving the lateral one-third of both eyelids, since birth. A slow increase in its size had been noticed for the past 2 years. On examination, a hairy nevus measuring 34 mm × 22 mm was noticed involving left eyelid skin, the mucocutaneous junction (MCJ), palpebral conjunctiva, and lateral canthus. Read More

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November 2017
4 Reads

Malignant melanoma presenting as amelanotic caruncular lesion in a child.

J AAPOS 2017 Dec 7;21(6):501-503. Epub 2017 Nov 7.

Department of Ophthalmology, Palmetto Health/University of South Carolina, Richland.

Conjunctival melanoma is a rare malignant neoplasm that can present in childhood in any part of the conjunctiva. The infrequency with which conjunctival melanoma is encountered in childhood caruncular lesions makes it a formidable but important aspect of the differential diagnosis. We report the case of a 10-year-old boy who presented with a left caruncular lesion. Read More

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December 2017

Eccrine-Centric Melanocytic Nevus.

Am J Dermatopathol 2018 May;40(5):375-377

Pathology and Laboratory Medicine Service, James A. Haley VA Hospital, Tampa, FL.

Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. Read More

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May 2018
1 Read

Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.

PLoS One 2017 1;12(11):e0186958. Epub 2017 Nov 1.

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.

We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Read More

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November 2017
2 Reads

CTNNB1-mutated melanocytic lesions with DPN like features: a distinct subtype of melanocytic tumors? A report of two cases.

Virchows Arch 2018 04 31;472(4):683-687. Epub 2017 Oct 31.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

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April 2018
2 Reads