10,688 results match your criteria Halo Nevus


A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd: YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians.

Dermatol Surg 2020 Jun 25. Epub 2020 Jun 25.

All authors are affiliated with the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated.

Objective: To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians.

Methods: Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002486DOI Listing

[Analysis of causes of death and etiological characteristics of skin tissue donors].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):446-450

Institute of Burns, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan Remains (Organs) Donation Registration and Skin Receiving Station, Wuhan 430060, China.

To investigate the causes of death and etiological characteristics of skin tissue donors, and to provide reference for allogeneic skin transplantation. From October 2008 to October 2018, 49 skin tissue donors accepted by the Burn Department of Wuhan Third Hospital met the inclusion criteria of this study, and a cross-sectional study was conducted. According to the cause of death, the donors were divided into accidental death group (19 cases) and non-accidental death group (30 cases). Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190307-00085DOI Listing

Alemtuzumab-induced halo nevus-like hypopigmentation -: New insights into secondary skin autoimmunity in response to an immune cell-depleting antibody.

J Eur Acad Dermatol Venereol 2020 Jun 24. Epub 2020 Jun 24.

Clinic of Neurology with Institute for Translational Neurology, University of Münster, Münster, Germany.

We describe a 33-year-old male patient who developed hypopigmentation around his melanocytic nevi with disappearance of the nevi in August 2018. In June 2016 he had been diagnosed with highly active RRMS and treated with alemtuzumab in September 2016 for the first time. In September 2017 another cycle of alemtuzumab was administered. Read More

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http://dx.doi.org/10.1111/jdv.16781DOI Listing

Combination of Congenital and Deep Penetrating Nevus by Acquisition of β-Catenin Activation.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Department of Dermatology, Fundación Jimenez-Diaz, Madrid, Spain.

Deep penetrating nevus (DPN) is an intradermal, sometimes compound benign melanocytic lesion, which involves the reticular dermis, occasionally reaching the subcutis, which can raise concern for melanoma both clinically and histologically. Recently, it has been genetically defined by the combination of MAPK activating and β-catenin activating mutations. We sought to investigate genetic alterations in 2 cases of combined nevi of congenital melanocytic and DPN. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001704DOI Listing

[Early-onset melanoma (congenital, neonatal, infantile): A systematic review of literature cases].

Ann Dermatol Venereol 2020 Jun 17. Epub 2020 Jun 17.

Groupe hospitalier Necker-Enfants malades, service d'anatomopathologie, AP-HP, Paris, France.

Introduction: Neonatal and infantile malignant melanoma is rare. It may be difficult to diagnose and often carries a poor prognosis.

Material And Methods: We decided to review the data on congenital, neonatal and infantile malignant melanomas in order to understand their presentation (clinical, histological, molecular), diagnosis, management and outcomes. Read More

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http://dx.doi.org/10.1016/j.annder.2020.05.001DOI Listing

Surgical treatment of a halo congenital melanocytic nevus in a 13-year-old-boy.

Dermatol Ther 2020 Jun 18:e13865. Epub 2020 Jun 18.

Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.1111/dth.13865DOI Listing

Eruptive Halo Naevi: A Possible Indicator of Malignant Disease in a Case Series of Post-Adolescent Patients.

Acta Derm Venereol 2020 Jun 16. Epub 2020 Jun 16.

Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. E-mail:

Halo naevi are considered benign. They occur in children and adolescents. Eruptive multiple halo naevi are infrequently seen in adults. Read More

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http://dx.doi.org/10.2340/00015555-3568DOI Listing

Molecular Analysis of Atypical Deep Penetrating Nevus Progressing to Melanoma.

J Cutan Pathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Deep penetrating nevi (DPN) are dermal-based, heavily pigmented melanocytic proliferations primarily resulting from mutations in B-catenin and BRAF or, less commonly, NRAS. DPNs are considered to be intermediate grade tumors which are stable with low risk of malignant transformation. The precise risk for transformation is unknown. Read More

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http://dx.doi.org/10.1111/cup.13775DOI Listing

Reflectance Confocal Microscopy of Pigmented Bowen's Disease: A Case Series of Difficult to Diagnose Lesions.

Case Rep Dermatol 2020 May-Aug;12(2):98-106. Epub 2020 May 15.

Department of Medicine and Medical Specialties, University of Alcalá, Madrid, Spain.

Pigmented Bowen's disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. Read More

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http://dx.doi.org/10.1159/000507916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265740PMC

[Clinical and pathological analysis of 64 patients with primary neoplasms of the lacrimal drainage system].

Zhonghua Yan Ke Za Zhi 2020 May;56(5):364-369

Tianjin Eye Hospital, Tianjin Key Lab. of Ophthalmology and Visual Science, Nankai University Affiliated Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin 300020, China.

To analyze the pathological classification and age distribution of primary neoplasms of the lacrimal drainage system. Retrospective case series study. A total of 64 patients (65 eyes) were diagnosed with primary neoplasms of the lacrimal drainage system and received surgery at Tianjin Eye Hospital from January 2006 to December 2016. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20190414-00216DOI Listing

A Retrospective Cohort Study of the Diagnostic Value of Different Subtypes of Atypical Pigment Network on Dermoscopy.

J Am Acad Dermatol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:

Background: Atypical network encompasses several patterns. Few studies assess the sensitivity, specificity, and positive and negative predictive values of network subtypes.

Objective: We assessed the diagnostic value of atypical network subtypes and their histopathologic correlates in cutaneous melanocytic lesions. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.05.080DOI Listing

Achieving a Good Aesthetic Result in the Correction of Giant Nevus of the Labiomental Area.

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2726. Epub 2020 Apr 27.

Department of Plastic Surgery, I.M. Sechenov First Moscow State Medical University Moscow, Russia.

Benign skin lesions of the face require appropriate surgical treatment. Giant pigmented skin lesions possess the high risk of malignancy which sometimes is not possible to diagnose preoperatively. Majority of the traditional techniques for lower lip and chin reconstruction were developed for the skin cancer resections and are extensively aggressive and disfiguring in case of benign lesions. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209834PMC

The presence of eccentric hyperpigmentation should raise the suspicion of melanoma.

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Melanocytic lesions with eccentric hyperpigmentation (EH), even though without other dermatoscopic features of melanoma, are often excised.

Objective: Aiming to understand whether the EH in a pigmented lesion is an accurate criterion of malignancy, we evaluated the capability of two evaluators, with different expertise, to correctly diagnose a melanoma when analysing a given lesion in toto versus a partial analysis, with only the EH or the non-hyperpigmented portion (non-EH) visible.

Methods: Dermatoscopic images of 240 lesions (107 melanomas and 133 nevi) typified by EH were selected. Read More

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http://dx.doi.org/10.1111/jdv.16604DOI Listing

[Genetic changes and biological potential of proliferative nodule in congenital pigmented nevus].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):458-463

Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

To study the genetic changes and biological potential of proliferative nodule in congenital melanocytic nevus. Whole-exome sequencing was carried out using the technique of next-generation sequencing (NGS) in order to detect the genomic alterations of two cases of proliferative nodules (PN) in congenital melanocytic nevi (CMN). Twelve cases of CMN and ten cases of malignant melanoma were used as benign and malignant controls, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190905-00485DOI Listing

Novel three-way complex rearrangement of TRPM1-PUM1-LCK in a case of agminated Spitz nevi arising in a giant congenital hyperpigmented macule.

Pigment Cell Melanoma Res 2020 May 9. Epub 2020 May 9.

Department of Biopathology, Center Léon Bérard, Lyon, France.

The genetic anomalies associated with the agminated variant of Spitz nevus have so far been limited to HRAS G13R mutations, especially when arising within a nevus spilus. A previous report exposed the case of a man with a giant pigmented macule involving his upper right limb and trunk. Since childhood, Spitz nevi have been periodically arising, within the pigmented area. Read More

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http://dx.doi.org/10.1111/pcmr.12884DOI Listing

Differential diagnosis and management of melanocytic lesions of the ocular surface

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

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http://dx.doi.org/10.1556/650.2020.31699DOI Listing

Dermoscopic characteristics of acral melanocytic nevi in children and adolescents.

Pediatr Dermatol 2020 Apr 14. Epub 2020 Apr 14.

Department of Dermatology, University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

Background/objective: There are limited data on the dermoscopic characteristics of acral nevi in the population under 18 years old. Our aim was to determine the frequency of acral volar nevi in children and adolescents, characterize their dermoscopic patterns, and identify relationships with age and location.

Methods: We prospectively examined the palms and soles of 1319 patients presenting to our outpatient clinic from July 2018 to April 2019. Read More

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http://dx.doi.org/10.1111/pde.14136DOI Listing

Osteonevus of Nanta: a case report in a combined melanocytic nevus.

An Bras Dermatol 2020 May - Jun;95(3):351-354. Epub 2020 Mar 19.

Service of Dermatology Surgery, Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.

Secondary osteoma cutis is a phenomenon that may occur in several conditions. When it occurs in a melanocytic nevus it is named osteonevus of Nanta, an event considered uncommon and characterized by the presence of bone formation adjacent or interposed with melanocytic cells. There are reports of its occurrence in various melanocytic lesions, being more frequently associated with intradermal nevus. Read More

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http://dx.doi.org/10.1016/j.abd.2019.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253887PMC

Localized vitiligo occurring in an old biopsy scar: A case report.

JAAD Case Rep 2020 Apr 25;6(4):326-328. Epub 2020 Mar 25.

57 West Dermatology, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2020.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109369PMC

Application and challenge of reflectance confocal microscopy in the diagnosis of pigmented nevus.

Skin Res Technol 2020 Apr 6. Epub 2020 Apr 6.

Department of Dermatology, The Third Xiangya Hospital of Central South University, Changsha, China.

Objective: To investigate the application and challenge of reflectance confocal microscopy (RCM) in the diagnosis of pigmented nevus.

Method: A total of 997 patients with clinical diagnosis of pigmented nevus were included in the study, and RCM imaging was performed on the lesion of each patient. A biopsy was performed in 78 of these patients for histological diagnosis. Read More

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http://dx.doi.org/10.1111/srt.12854DOI Listing

Genetic analyses of mosaic neurofibromatosis type 1 with giant café-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi.

J Dermatol 2020 Jun 4;47(6):658-662. Epub 2020 Apr 4.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Neurofibromatosis type 1 (NF1) is a genodermatosis caused by heterozygous germ line variations in the NF1 gene. A second-hit NF1 aberration results in the formation of café-au-lait macules, cutaneous neurofibroma and plexiform neurofibroma (PNF). Mosaic NF1 (mNF1), caused by a postzygotic NF1 mutation, is characterized by localized or generalized NF1-related manifestations. Read More

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http://dx.doi.org/10.1111/1346-8138.15327DOI Listing

Follicular Becker's Nevus: A New Clinical Variant.

Indian J Dermatol 2020 Mar-Apr;65(2):130-132

Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.

Becker's nevus, also known as pigmented hairy epidermal nevus, is characteristically described as a unilateral, hairy, light to dark brown macule with sharply outlined but irregular border. The etiopathogenesis of Becker's nevus is still not clearly understood. Perifollicular pigmentation has been described earlier by some authors. Read More

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http://dx.doi.org/10.4103/ijd.IJD_476_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059461PMC

BRAF V600E mutational load as a prognosis biomarker in malignant melanoma.

PLoS One 2020 13;15(3):e0230136. Epub 2020 Mar 13.

Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, UPV/EHU, Leioa, Spain.

Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing the heterogeneity of mutational load of BRAF V600E in biopsies of melanoma patients of different stages, and investigating its potential as a prognosis factor. Mutational load of BRAF V600E was analyzed by digital PCR in 78 biopsies of melanoma patients of different stages and 10 nevi. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069620PMC

Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.

Am J Surg Pathol 2020 Jun;44(6):805-816

Departments of Pathology.

Melanocytic tumors with inactivation of protein kinase A regulatory subunit-α (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under various names, including epithelioid blue nevus, pigmented epithelioid melanocytoma (PEM) and animal-type melanoma. Although a subset of PEM harbor BRAF activating mutations and biallelic inactivation of PRKAR1A, there are only a few reports of melanomas, or of tumors with genomic alterations beyond those of PEMs. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001458DOI Listing

Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

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http://dx.doi.org/10.1177/1120672120906999DOI Listing
February 2020

Giant Congenital Melanocytic Nevi Successfully Treated with Combined Laser Therapy.

Indian Dermatol Online J 2020 Jan-Feb;11(1):79-82. Epub 2020 Jan 13.

Department of Dermatology. Sakhiya Skin Clinic PVT LTD, Surat, Gujarat, India.

Congenital melanocytic nevi are benign proliferations of cutaneous melanocytes that arise as a result of abnormal growth, development, or migration of melanoblasts. Clinically, the giant congenital nevus is greater than 20 cm in size, pigmented and often hairy. The risk of malignant melanoma for the giant nevi is almost 6%. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_107_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001409PMC
January 2020

Retrospective photographic review of nontattoo indications treated by picosecond laser.

J Cosmet Dermatol 2020 Mar;19(3):612-621

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation.

Objective: We report our experience treating our patients for different indications using a PS laser. Read More

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http://dx.doi.org/10.1111/jocd.13285DOI Listing

Benign tumoral melanosis of a cervical lymph node in a child.

Int J Pediatr Otorhinolaryngol 2020 Jan 30;132:109916. Epub 2020 Jan 30.

Department of Otolaryngology, Children's Hospital Colorado, 12631 E. 17th Ave., B-205, Aurora, CO, 80045, USA.

We present a pediatric case of benign tumoral melanosis in a cervical lymph node arising from congenital pigmented lesions of the anterior neck. This is the first reported pediatric case not associated with regressed melanoma or trauma. Tumoral melanosis is a rare phenomenon which describes a pigmented lesion like melanoma; however, histology demonstrates melanin-laden macrophages without malignant cells. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.109916DOI Listing
January 2020

Choroidal Nevus and Melanoma in Patients with Oculocutaneous Albinism.

Ocul Oncol Pathol 2020 Jan 10;6(1):31-34. Epub 2019 Jul 10.

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India.

Background: There are limited reports of uveal "melanocytic" lesions in patients with oculocutaneous albinism, with no reports from Asia.

Objectives: In this study, we report 3 eyes with uveal "melanocytic" lesions in Asian patients with oculocutaneous albinism.

Methods: Retrospective small case series. Read More

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http://dx.doi.org/10.1159/000500784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984154PMC
January 2020

Bidimensional Fuzzy Entropy: Principle Analysis and Biomedical Applications.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:4811-4814

Since the 2010's, entropy measures have been extended from the 1D to the 2D case to deal with images and are forming potent bidimensional irregularity measures. In our work, we study a new 2D entropy measure - the so-called bidimensional fuzzy entropy (FuzEn) - that out-performs existing bidimensional entropy measures. We first assess its sensitivity to parameters, then analyze its behavior upon rotation and translation, and finally show its multiscale application in the biomedical field (dermoscopic images). Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857176DOI Listing

Convolutional Neural Network Approach to Classify Skin Lesions Using Reflectance Confocal Microscopy.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:4754-4757

We propose an approach based on a convolutional neural network to classify skin lesions using the reflectance confocal microscopy (RCM) mosaics. Skin cancers are the most common type of cancers and a correct, early diagnosis significantly lowers both morbidity and mortality. RCM is an in-vivo non-invasive screening tool that produces virtual biopsies of skin lesions but its proficient and safe use requires hard to obtain expertise. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856731DOI Listing

Wide Area Digital Dermoscopy for Congenital Melanocytic Nevi: Report of 3 Cases.

Dermatol Pract Concept 2020 31;10(1):e2020023. Epub 2019 Dec 31.

Department of Dermatology & Cutaneous Oncology, Hospital Santa Casa de Curitiba, Brazil.

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http://dx.doi.org/10.5826/dpc.1001a23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936646PMC
December 2019

A pigmented lesion on the eye.

BMJ 2020 01 9;368:l6810. Epub 2020 Jan 9.

Department of Ophthalmology & Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1136/bmj.l6810DOI Listing
January 2020

Eruptive disseminated Spitz nevi - Case report.

An Bras Dermatol 2020 Jan - Feb;95(1):71-74. Epub 2019 Dec 12.

Dermatology Service, University of Chile Clinical Hospital, University of Chile, Santiago, Chile.

Spitz nevus is a benign melanocytic lesion, which presents in several ways: solitary, agminated, or disseminated. The disseminated variant is uncommon; it may have a rapid evolution (the eruptive form) and be difficult to manage. This report presents the case of a 24-year-old patient with multiple papules on his limbs, which had appeared four years previously. Read More

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http://dx.doi.org/10.1016/j.abd.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058877PMC

The color of skin: white diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):561-579. Epub 2019 Jul 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

White diseases are a heterogenous group characterized by hypopigmentation or depigmentation. Skin and eye color are determined by the number and size of melanosomes present. Melanin is produced by melanosomes in the melanocytes present within the epidermis of the skin, uvea, and retinal pigmented epithelium (RPE). Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.018DOI Listing

The color of skin: gray diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):507-515. Epub 2019 Jul 31.

Department of Dermatology, Andrology and STIs, Ain Shams University Hospital, Cairo, Egypt. Electronic address:

Gray diseases are a group of skin disorders characterized mainly by gray discoloration with or without involving the mucous membranes and nails. These diseases may be hereditary or acquired. Some of the better-known hereditary entities are dermal melanocytosis, incontinentia pigmenti, hypomelanosis of Ito, hemochromatosis, ochronosis, and silvery hair syndrome. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.011DOI Listing

The color of skin: black diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):447-467. Epub 2019 Aug 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Gradations in skin color are a consequence of differing amounts of melanin and their varying distribution. Although many darkly pigmented skin lesions are melanocytic and can be attributed to melanin content, the color of a black lesion can also be due to blood, necrotic tissue, or exogenous pigment. The source, pattern, and distribution of the color in black lesions usually offer important insight into its etiology. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.08.003DOI Listing

An intuitive explanation of dermoscopic structures by digitally reconstructed pathological horizontal top-down view images.

Sci Rep 2019 12 27;9(1):19875. Epub 2019 Dec 27.

Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-Ku, Hamamatsu, 431-3192, Japan.

Dermoscopy is a convenient tool to diagnose melanocytic lesions, especially nevus and melanoma. Various pigmented structures, including pigment network, dots and globules, and streaks, are observed in dermoscopy. Usually, 2D vertical images are used to explain the correlation of dermoscopy and histopathology. Read More

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http://dx.doi.org/10.1038/s41598-019-56522-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934765PMC
December 2019

Eruptive Melanocytic Nevi Secondary to Encorafenib for BRAF Mutant Metastatic Colorectal Cancer.

In Vivo 2020 Jan-Feb;34(1):441-445

Unit of Dermatology, University of Padua, Padua, Italy

A 59-year-old woman, undergoing treatment with encorafenib for metastatic BRAF mutated colorectal cancer, developed during the first two months of therapy multiple eruptive nevi and changes in pre-existing nevi. Development of eruptive nevi has increasingly been reported in association with medications, most frequently conventional immunosuppressants and biologics. Some drugs are associated with eruptive nevi through an indirect effect of their mechanism of action, whereas other drugs are directly implicated in melanocyte proliferation. Read More

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http://dx.doi.org/10.21873/invivo.11793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984112PMC

Blue rubber bleb nevus: a rare cause of GI bleeding-review of management.

BMJ Case Rep 2019 Dec 16;12(12). Epub 2019 Dec 16.

Gastroenterology, AdventHealth Medical Group, Apopka, Florida, USA.

Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital vascular anomaly syndrome characterised by multifocal venous vascular malformations. It involves skin, central nervous systems, liver, muscles and gastrointestinal (GI) tract resulting in intestinal haemorrhage and anaemia. Patients with BRBNS experience severe chronic anaemia without any diagnosis requiring multiple transfusions and hospitalisations. Read More

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http://dx.doi.org/10.1136/bcr-2019-231561DOI Listing
December 2019

Visuelle Echos der Menschwerdung auf der Haut.

Authors:
H Holzgreve

MMW Fortschr Med 2019 12;161(21-22):35

.

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http://dx.doi.org/10.1007/s15006-019-1231-zDOI Listing
December 2019

Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.

Sci Rep 2019 12 3;9(1):18204. Epub 2019 Dec 3.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11. Read More

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http://dx.doi.org/10.1038/s41598-019-54786-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890774PMC
December 2019

[Suspicious hyperpigmentation with parallel ridge pattern on acral skin : Three case reports].

Hautarzt 2020 02;71(2):154-157

Univ.-Klinik für Dermatologie und Venerologie, LKH-Univ. Klinikum Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.

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http://dx.doi.org/10.1007/s00105-019-04511-3DOI Listing
February 2020

Neurofibromatosis with vitiligo: an uncommon association rather than coexistence?

An Bras Dermatol 2019 Sep - Oct;94(5):624-626. Epub 2019 Sep 30.

Dermatology Department, PGIMER& Dr. Ram Manohar Lohia Hospital, New Delhi, India.

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http://dx.doi.org/10.1016/j.abd.2019.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857576PMC
December 2019

Basal cell carcinoma arising in nevus sebaceous during pregnancy.

Cutis 2019 Oct;104(4):E21-E23

Department of Dermatology, Saint Louis University, USA.

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October 2019

Giant congenital melanocytic nevi.

Bol Med Hosp Infant Mex 2019 ;76(6):251-258

Departamento de Micología, Hospital General Dr. Manuel Gea González, Ciudad de México. México.

Giant congenital melanocytic nevi (GCMN) are melanocytic lesions secondary to the abnormal migration of melanoblasts during the embryogenesis, affecting approximately one in 20,000 live births. They are usually present since birth and are distinguished by changing their morphological characteristics within time, and increasing their size parallel to the growth of the child, reaching a diameter ≥ 20 cm in adulthood. The importance of the GCMN lies in the complications associated to them; mainly the development of melanoma or neurocutaneous melanosis, in addition to the psychological or social impact that generates in most of the cases. Read More

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http://dx.doi.org/10.24875/BMHIM.18000103DOI Listing

MicroRNA Profiling in Benign and Malignant Conjunctival Melanocytic Lesions.

Ophthalmology 2020 03 12;127(3):432-434. Epub 2019 Oct 12.

Section Ophthalmic Pathology, Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; The Rotterdam Eye Hospital, Rotterdam, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2019.10.008DOI Listing

Melanocytoma of the optic disk: A review.

Indian J Ophthalmol 2019 12;67(12):1949-1958

Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. Today, however, it is generally recognized by its typical clinical features that differ from most melanomas and erroneous enucleation is rarely done. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2039_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896535PMC
December 2019