28,652 results match your criteria Hallucinogens


Contribution of a novel gene to lysergic acid amide synthesis in Metarhizium brunneum.

BMC Res Notes 2022 May 18;15(1):183. Epub 2022 May 18.

Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.

Objective: The fungus Metarhizium brunneum produces ergot alkaloids of the lysergic acid amide class, most abundantly lysergic acid α-hydroxyethylamide (LAH). Genes for making ergot alkaloids are clustered in the genomes of producers. Gene clusters of LAH-producing fungi contain an α/β hydrolase fold protein-encoding gene named easP whose presence correlates with LAH production but whose contribution to LAH synthesis in unknown. Read More

View Article and Full-Text PDF

Indeterminacy of cannabis impairment and ∆-tetrahydrocannabinol (∆-THC) levels in blood and breath.

Sci Rep 2022 May 18;12(1):8323. Epub 2022 May 18.

RCU Labs, Inc., 408 Sunrise Avenue, Roseville, CA, 95661-4123, USA.

Previous investigators have found no clear relationship between specific blood concentrations of ∆-tetrahydrocannabinol (∆-THC) and impairment, and thus no scientific justification for use of legal "per se" ∆-THC blood concentration limits. Analyzing blood from 30 subjects showed ∆-THC concentrations that exceeded 5 ng/mL in 16 of the 30 subjects following a 12-h period of abstinence in the absence of any impairment. In blood and exhaled breath samples collected from a group of 34 subjects at baseline prior to smoking, increasing breath ∆-THC levels were correlated with increasing blood levels (P < 0. Read More

View Article and Full-Text PDF

Psilocybin-induced takotsubo cardiomyopathy.

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Emergency Department, Aberdeen Royal Infirmary, Aberdeen, UK

We present a case of takotsubo cardiomyopathy following recreational ingestion of (known as 'magic mushrooms'). The patient presented with respiratory distress and pulmonary oedema responding to standard medical measures. Investigations included: echocardiogram, cardiac MRI and angiogram. Read More

View Article and Full-Text PDF

Asclepius Revisited-Ancient Myth and 21st-Century Psychedelic Medicine.

JAMA 2022 05;327(19):1851-1852

John A. Burns School of Medicine, Department of Psychiatry, University of Hawai'i at Manoa, Honolulu.

View Article and Full-Text PDF

Self-Care Practices with Psychedelics - A Qualitative Study of Users' Perspectives.

J Psychoactive Drugs 2022 May 15:1-11. Epub 2022 May 15.

Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.

This article explores the psychedelic experience from the users' point of view and through the lens of self-care, a concept within the domain of health and well-being. In a time of renewed interest in psychedelic-assisted psychotherapy, we aim to contribute to a better understanding of these substances by exploring their role in different settings. A phenomenological approach was used in this study. Read More

View Article and Full-Text PDF

Virtual Daime: When Psychedelic Ritual Migrates Online.

Authors:
Ido Hartogsohn

Front Psychol 2022 29;13:819994. Epub 2022 Apr 29.

The Graduate Program in Science, Technology and Society, The Interdisciplinary Studies Unit, Bar Ilan University, Ramat Gan, Israel.

During the 2020 COVID-19 epidemic a variety of social activities migrated online, including religious ceremonies and rituals. One such instance is the case of Santo Daime, a Brazilian rainforest religion that utilizes the hallucinogenic brew ayahuasca in its rituals. During the pandemic, multiple Santo Daime rituals involving the consumption of ayahuasca took place online, mediated through Zoom and other online platforms. Read More

View Article and Full-Text PDF

Safety considerations in the evolving legal landscape of psychedelic-assisted psychotherapy.

Subst Abuse Treat Prev Policy 2022 May 14;17(1):37. Epub 2022 May 14.

Department of Medicine, University of British Columbia, British Columbia Centre on Substance Use, 400-1045 Howe St, Vancouver, BC, V6Z 2A9, Canada.

International drug policy is rapidly evolving in tandem with promising evidence for psychedelic-assisted psychotherapy (PAP) in treating a range of mental health conditions. Canada is among the countries increasingly expanding access to psychedelic substances for therapeutic purposes. The 8-year ban on medical exemptions through the Canadian Special Access Programme was recently reversed in January 2022 and the first exemptions for legal possession and personal use of psilocybin mushrooms were granted in 2020, nearly 50 years since their criminalization. Read More

View Article and Full-Text PDF

Allosteric Binding of MDMA to the Human Serotonin Transporter (hSERT) via Ensemble Binding Space Analysis with ΔG Calculations, Induced Fit Docking and Monte Carlo Simulations.

Molecules 2022 May 6;27(9). Epub 2022 May 6.

Laboratory of Computational Molecular Simulations, Departamento de Farmacia, Benemérita Universidad Autónoma de Puebla, Puebla 72592, Mexico.

Despite the recent promising results of MDMA (3,4-methylenedioxy-methamphetamine) as a psychotherapeutic agent and its history of misuse, little is known about its molecular mode of action. MDMA enhances monoaminergic neurotransmission in the brain and its valuable psychoactive effects are associated to a dual action on the 5-HT transporter (SERT). This drug inhibits the reuptake of 5-HT (serotonin) and reverses its flow, acting as a substrate for the SERT, which possesses a central binding site (S1) for antidepressants as well as an allosteric (S2) one. Read More

View Article and Full-Text PDF

Direct Quantitation of Phytocannabinoids by One-Dimensional H qNMR and Two-Dimensional H-H COSY qNMR in Complex Natural Mixtures.

Molecules 2022 May 5;27(9). Epub 2022 May 5.

Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

The widespread use of phytocannabinoids or cannabis extracts as ingredients in numerous types of products, in combination with the legal restrictions on THC content, has created a need for the development of new, rapid, and universal analytical methods for their quantitation that ideally could be applied without separation and standards. Based on previously described qNMR studies, we developed an expanded H qNMR method and a novel 2D-COSY qNMR method for the rapid quantitation of ten major phytocannabinoids in cannabis plant extracts and cannabis-based products. The H qNMR method was successfully developed for the quantitation of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabinol (CBN), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabigerol (CBG), cannabigerolic acid (CBGA), Δ9-tetrahydrocannabinol (Δ9-THC), Δ9-tetrahydrocannabinolic acid (Δ9-THCA), Δ8-tetrahydrocannabinol (Δ8-THC), cannabielsoin (CBE), and cannabidivarin (CBDV). Read More

View Article and Full-Text PDF

Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro.

Molecules 2022 Apr 30;27(9). Epub 2022 Apr 30.

School of Pharmacy, Lanzhou University, West Donggang Road No. 199, Lanzhou 730000, China.

Dairy mastitis is a disease of dairy cattle caused by a variety of pathogenic microorganisms which has biought huge economic losses aused huge economic losses to the world. In this paper, Harmine derivatives and tetrahydro-β-carboline derivatives synthesized by the splice method are shown to have a good inhibitory effect on the pathogenic bacteria of dairy mastitis. The results of a bacteriostatic test on pathogenic bacteria of dairy cow mastitis (, , and ) showed that compound had the best bacteriostatic effect on , with a mic value of 43. Read More

View Article and Full-Text PDF

Cigarillo Flavor and Motivation to Quit among Co-Users of Cigarillos and Cannabis: A Structural Equation Modeling Approach.

Int J Environ Res Public Health 2022 May 8;19(9). Epub 2022 May 8.

Division of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.

Flavored cigar restrictions have the potential to benefit public health. Flavor availability facilitates cigarillo use, but it is unknown if flavor impacts patterns of co-use of cigarillos and cannabis, an increasingly prevalent behavior among young adults. Data were collected (2020-2021) in a cross-sectional online survey administered to a convenience sample of young adults who smoked cigarillos from 15 areas with high cigar use prevalence. Read More

View Article and Full-Text PDF

Comparison of the Agonist/Antagonist Tensional Balance of the Knee between Two Isokinetic Positions: A Pilot Study on a Sample of High-Level Competitive Soccer Players.

Int J Environ Res Public Health 2022 Apr 28;19(9). Epub 2022 Apr 28.

Laboratory of Applied Physiology (FISAP), University of León, 24404 Ponferrada, Spain.

Isokinetic knee dynamometry evolves towards more precise techniques, such as the calculation of the functional ratio. This study evaluated the influence of an intermediate hip position called the unified reclined position (URP) compared to the classic sitting position, (CSP) on hamstring eccentric PT values (H) and conventional (H/Q) and functional (H/Q) ratios. Twenty Spanish high-level competitive soccer players (20. Read More

View Article and Full-Text PDF

Changes in the Dissolved Organic Matter Characteristics Released from Sediment According to Precipitation in the Namhan River with Weirs: A Laboratory Experiment.

Int J Environ Res Public Health 2022 Apr 19;19(9). Epub 2022 Apr 19.

Department of Environmental Science and Engineering, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.

In this study, changes in the properties of dissolved organic matter (DOM) released from sediments into water layers were investigated. To analyze the spatial and temporal variation in dissolved organic carbon (DOC), sediment and bottom water samples were collected upstream of the Gangcheon, Yeoju, and Ipo weirs of the Namhan River during the rainy and non-rainy seasons. The initial DOC was correlated with precipitation (R = 0. Read More

View Article and Full-Text PDF

Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro.

Cells 2022 Apr 20;11(9). Epub 2022 Apr 20.

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.

Cannabinoids, mainly cannabidiol (CBD) and Δ-tetrahydrocannabinol (THC), are the most studied group of compounds obtained from because of their several pharmaceutical properties. Current evidence suggests a crucial role of cannabinoids as potent anti-inflammatory agents for the treatment of chronic inflammatory diseases; however, the mechanisms remain largely unclear. Cytokine storm, a dysregulated severe inflammatory response by our immune system, is involved in the pathogenesis of numerous chronic inflammatory disorders, including coronavirus disease 2019 (COVID-19), which results in the accumulation of pro-inflammatory cytokines. Read More

View Article and Full-Text PDF

Getting to the heart of cannabis health risks.

Authors:
Thomas P Sakmar

Cell 2022 May;185(10):1623-1625

Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA. Electronic address:

In this issue of Cell, Wei et al. show that the increased cardiovascular risks associated with cannabis use are mediated by proinflammatory cannabinoid 1 (CB1) receptor signaling, which can be ameliorated with the natural antioxidant agent genistein. Read More

View Article and Full-Text PDF

Strong Ethnic Identity Buffers the Association of Heterosexism with Substance Use Among Black Sexual Minority Men.

J Racial Ethn Health Disparities 2022 May 12. Epub 2022 May 12.

Human Development and Family Sciences, University of Connecticut, Storrs, CT, 06279-1248, USA.

Introduction: Heterosexist stigma, including microaggressions experienced in their own racial/ethnic communities, may partially explain disproportionate levels of substance use involvement among Black sexual minority men (BSMM). A strong sense of ethnic identity may provide BSMM with a protective resource. The purpose of this study was to explore associations between ethnic identity and substance use in BSMM. Read More

View Article and Full-Text PDF

Manifest your desires: Psychedelics and the self-help industry.

Int J Drug Policy 2022 May 8;105:103704. Epub 2022 May 8.

McMaster University, Psychology, Canada.

A psychedelic industrial complex is emerging as new research on these substances and their effects is being approved. These substances show promise, but much remains unknown about their potential for both benefit and harm. Despite the paucity of reliable mechanistic evidence, some entrepreneurs have already begun to market psychedelic advice. Read More

View Article and Full-Text PDF

Augmentation des cas de schizophrénie associée à l’usage du cannabis.

Authors:
Alexander Tomei

Rev Med Suisse 2022 May;18(781):963

Service de médecine des addictions, CHUV, Lausanne.

View Article and Full-Text PDF

Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, and evaluation.

Drug Deliv 2022 Dec;29(1):1477-1491

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Despite high efficiency of domperidone (DOM) in prophylaxis of emesis accompanied with radiotherapy and chemotherapy, it still can bother cancer patients by its powerful side effects and difficulty of its oral administration. The study was designed to develop and optimize DOM loaded ethosomal gel for rectal transmucosal delivery. Ethosomal formulations were prepared using a 2, 5 full-factorial design where the impact of lecithin concentration and additives were investigated. Read More

View Article and Full-Text PDF
December 2022

[Spectral characteristics of dissolved organic matter and its environmental responses across successional stages in a glacier retreat area].

Ying Yong Sheng Tai Xue Bao 2022 Apr;33(4):1074-1082

Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China.

Dissolved organic matter (DOM), the most active type of soil organic matter, plays a key role in soil biogeochemical cycling. Therefore, exploring the source, composition, environmental response, and accumulation mechanism of DOM during vegetation succession has great significance for predicting soil carbon cycling. In this study, DOM was extracted from topsoil and subsoil at plots after 12, 30, 40, 50, 80, and 120 years of primary succession along the Hailuogou Glacier retreat area. Read More

View Article and Full-Text PDF

50 Years Ago in TheJournalofPediatrics: Accidental Ingestion of LSD: Everything Old Is New Again.

J Pediatr 2022 May;244:57

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

View Article and Full-Text PDF

Microbial community functioning during plant litter decomposition.

Sci Rep 2022 May 6;12(1):7451. Epub 2022 May 6.

Max Planck Institute for Biogeochemistry, Jena, Germany.

Microbial life in soil is fueled by dissolved organic matter (DOM) that leaches from the litter layer. It is well known that decomposer communities adapt to the available litter source, but it remains unclear if they functionally compete or synergistically address different litter types. Therefore, we decomposed beech, oak, pine and grass litter from two geologically distinct sites in a lab-scale decomposition experiment. Read More

View Article and Full-Text PDF

Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning.

Transl Psychiatry 2022 May 6;12(1):188. Epub 2022 May 6.

School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.

While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempts to identify probable causal relationships in correlational data using conditional probabilities to estimate directional associations between a set of interrelated variables. In this study, we employed BCN modeling in 637 adolescents from the IMAGEN study who were cannabis naïve at age 14 to provide evidence that the accelerated prefrontal cortical thinning found previously in adolescent cannabis users by Albaugh et al. Read More

View Article and Full-Text PDF

The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol.

Syst Rev 2022 May 5;11(1):85. Epub 2022 May 5.

Centre for Mental Health, Department of Psychological Sciences, Swinburne University of Technology, Melbourne, Australia.

Background: There is currently renewed interest in the use of psychedelic therapy in the treatment of psychiatric disorders, including depression. The proposed systematic review will aim to identify, evaluate and summarise the psychological processes of change underlying psychedelic therapy for depression in the current literature and consider the implications these processes may have on the psychotherapy component of treatment.

Methods: Scopus, PsycINFO, PubMed and Web of Science databases will be searched using relevant terms. Read More

View Article and Full-Text PDF

Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis.

Cochrane Database Syst Rev 2022 05 5;5:CD013444. Epub 2022 May 5.

Review Production and Quality Unit, Editorial & Methods Department, Cochrane Central Executive, London, UK.

Background: Spasticity and chronic neuropathic pain are common and serious symptoms in people with multiple sclerosis (MS). These symptoms increase with disease progression and lead to worsening disability, impaired activities of daily living and quality of life. Anti-spasticity medications and analgesics are of limited benefit or poorly tolerated. Read More

View Article and Full-Text PDF

Caffeine Encapsulation in Metal Organic Framework MIL-53(Al) at Pilot Plant Scale for Preparation of Polyamide Textile Fibers with Cosmetic Properties.

ACS Appl Mater Interfaces 2022 May 4;14(19):22476-22488. Epub 2022 May 4.

Instituto de Nanociencia y Materiales de Aragón (INMA), Universidad de Zaragoza-CSIC, 50009, Zaragoza, Spain.

Currently in the marketplace, we can find clothing items able to release skin-friendly ingredients while wearing them. These innovative products with high-added value are based on microencapsulation technology. In this work, due to its lightness, flexibility, porosity, chemical affinity and adsorption capacity, metal-organic framework (MOF) MIL-53(Al) was the selected microcapsule to be synthesized at a large scale and subsequent caffeine encapsulation. Read More

View Article and Full-Text PDF

MDMA treatment paired with a trauma-cue promotes adaptive stress responses in a translational model of PTSD in rats.

Transl Psychiatry 2022 May 3;12(1):181. Epub 2022 May 3.

Department of Psychology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, combined with psychotherapy has demonstrated efficacy for the treatment of chronic posttraumatic stress disorder (PTSD) patients. This controlled prospective study aimed to assess the bio-behavioral underpinnings of MDMA in a translational model of PTSD. Rats exposed to predator-scent stress (PSS) were subjected to a trauma-cue at day 7 shortly after single-dose MDMA injection (5 mg/kg). Read More

View Article and Full-Text PDF

[Medically unexplained or not? Be aware of a somatic cause of Medically Unexplained Symptoms].

Ned Tijdschr Geneeskd 2022 02 24;166. Epub 2022 Feb 24.

GGZ Breburg, Tilburg.

In 2 cases of men aged 26 and 55 respectively we illustrate the complexity of MUS patients since in both cases a somatic diagnosis was missed. The first patient presented with an inability to walk and persistent pain. Because of his symptoms he lost his job, had depressive moods and used alcohol and cannabis. Read More

View Article and Full-Text PDF
February 2022