11,568 results match your criteria Hairy Cell Leukemia


Structure and biomechanics of the antennal grooming mechanism in the southern green stink bug Nezara viridula.

J Insect Physiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Functional Morphology and Biomechanics, Kiel University, Germany.

Insects devote a high amount of time to self-groom to remove foreign material, especially from their sensory appendages. Using various microscopy techniques and behavioural experiments on intact and ablated insects, the present study investigates the antennal grooming of the green stinkbug Nezara viridula, which represents a serious pest of different crops in most areas of the world. The antennal grooming behaviour encompass an action of scraping involving the tibial comb complex (tibial comb + fossula) of both forelegs, generally followed by the tibial comb complex grooming of one leg using the tarsal hairy pad of the opposite leg (rubbing). Read More

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December 2018

Protists and other organisms on a minute snail periostracum.

Braz J Biol 2018 Dec 3. Epub 2018 Dec 3.

Estación Biológica Juan Roberto Zarruk, Universidad Centroamericana - UCA, Rotonda Rubén Darío 150 m Oeste, Managua, Nicaragua.

Since the foundation of the Malacological Center in 1980, Universidad Centro Americana (UCA), Managua-Nicaragua, has been monitoring and collecting the marine, terrestrial, fluvial and lake mollusk population of the country. Many specimens have been photographed by Scanning Electronic Microscope (SEM), and in one of these, observation of the hairy periostracum reveals a seemingly thriving population of minute protists in possible symbiosis with their host. Adequate magnification and comparison with previous studies allowed the determination of these hosts as diatoms, testaceous amoebae, yeast, phacus, spores and other undetermined organisms which occur in tropical forests on rocks, trees and leaves. Read More

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December 2018

Investigation of the Developmental Requirements of Drosophila HP1 and Insulator Protein Partner, HIPP1.

G3 (Bethesda) 2018 Dec 4. Epub 2018 Dec 4.

University of Iowa

Drosophila Suppressor of Hairy-wing [Su(Hw)] is a multifunctional zinc finger DNA binding protein. Transcriptional regulation by Su(Hw) is essential in the ovary and testis, where Su(Hw) functions primarily as a repressor. Recently, the HP1a and Insulator Partner Protein 1 (HIPP1) was found to extensively co-localize with Su(Hw) and other insulator binding proteins in euchromatic regions of the genome, and with Heterochromatin Protein 1a (HP1a) in heterochromatic regions. Read More

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December 2018

Crop Rotations and Poultry Litter Affect Dynamic Soil Chemical Properties and Soil Biota Long Term.

J Environ Qual 2018 Nov;47(6):1327-1338

Dynamic soil chemical interactions with conservation agricultural practices and soil biota are largely unknown. Therefore, this study aims to quantify long-term (12-yr) impacts of cover crops, poultry litter, crop rotations, no-tillage, and their interactions on dynamic soil properties and to determine their relationships with nutrient cycling, crop yield, and soil biodiversity (soil microbial and earthworm communities). Main effects were 13 different cropping sequences of soybean [ (L. Read More

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November 2018

Synchronous follicular non-Hodgkin's lymphoma and hairy cell leukaemia: a case report.

Ann Hematol 2018 Dec 4. Epub 2018 Dec 4.

Department of Haematology, St. Vincent's University Hospital, Dublin, Ireland.

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December 2018

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.

Cell Rep 2018 Nov 29. Epub 2018 Nov 29.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address:

Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Read More

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November 2018
1 Read

Identification and characterization of GmMYB118 responses to drought and salt stress.

BMC Plant Biol 2018 Dec 3;18(1):320. Epub 2018 Dec 3.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement, Key Laboratory of Biology and Genetic Improvement of Triticeae Crops, Ministry of Agriculture, Beijing, 100081, China.

Background: Abiotic stress severely influences plant growth and development. MYB transcription factors (TFs), which compose one of the largest TF families, play an important role in abiotic stress responses.

Result: We identified 139 soybean MYB-related genes; these genes were divided into six groups based on their conserved domain and were distributed among 20 chromosomes (Chrs). Read More

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December 2018

Recent advances in nanoengineering cellulose for cargo delivery.

J Control Release 2018 Nov 27. Epub 2018 Nov 27.

Department of Bioengineering, University of California - Los Angeles, 410 Westwood Plaza, Los Angeles, CA 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA; Department of Radiological Sciences, David Geffen School of Medicine, University of California - Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, 5531 Boelter Hall, Los Angeles, CA 90095, USA; Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address:

The recent decade has witnessed a growing demand to substitute synthetic materials with naturally-derived platforms for minimizing their undesirable footprints in biomedicine, environment, and ecosystems. Among the natural materials, cellulose, the most abundant biopolymer in the world with key properties, such as biocompatibility, biorenewability, and sustainability has drawn significant attention. The hierarchical structure of cellulose fibers, one of the main constituents of plant cell walls, has been nanoengineered and broken down to nanoscale building blocks, providing an infrastructure for nanomedicine. Read More

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November 2018
4 Reads

CYP76B74 catalyzes the 3''-hydroxylation of geranylhydroquinone in shikonin biosynthesis.

Plant Physiol 2018 Nov 29. Epub 2018 Nov 29.

State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences CITY: Beijing China [CN]

Shikonin and its derivatives are the most abundant naphthoquinone pigments formed in species of the medicinally and economically valuable Boraginaceae. A key step in the shikonin biosynthetic pathway, namely the C-3'' hydroxylation of prenylated phenolic intermediate geranylhydroquinone, is expected to be catalyzed by a cytochrome P450. To find cytochrome P450 candidates with transcription profiles similar to those of the known upstream genes, we carried out co-expression analysis of transcriptome datasets of shikonin-proficient and shikonin-deficient cell lines and spatial expression in different organs of Arnebia euchroma. Read More

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November 2018
3 Reads

MAB21L1 loss of function causes a syndromic neurodevelopmental disorder with distinctive erebellar, cular, cranioacial and enital features (COFG syndrome).

J Med Genet 2018 Nov 28. Epub 2018 Nov 28.

Genome Research Division, Human Genetics Department, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Putative nucleotidyltransferase MAB21L1 is a member of an evolutionarily well-conserved family of the male abnormal 21 (MAB21)-like proteins. Little is known about the biochemical function of the protein; however, prior studies have shown essential roles for several aspects of embryonic development including the eye, midbrain, neural tube and reproductive organs.

Objective: A homozygous truncating variant in has recently been described in a male affected by intellectual disability, scrotal agenesis, ophthalmological anomalies, cerebellar hypoplasia and facial dysmorphism. Read More

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November 2018

The "hairy beast"-Zorotypus hirsutus sp. n., an unusual new species of Zoraptera (Insecta) from Burmese amber.

Zootaxa 2018 Nov 2;4508(4):562-568. Epub 2018 Nov 2.

Graduate School of Symbiotic Systems Science and Technology, Fukushima University, Kanayagawa 1, Fukushima, Fukushima 960-1296, Japan..

A new species of the order Zoraptera, Zorotypus hirsutus Mashimo sp. n., is described from mid-Cretaceous Burmese amber. Read More

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November 2018

Cutaneous adverse events associated with purine analogs in the treatment of hairy cell leukemia.

Int J Dermatol 2018 Nov 27. Epub 2018 Nov 27.

Division of Dermatology, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH, USA.

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November 2018
1 Read

Expression of a tobacco nicotine biosynthesis gene depends on the JRE4 transcription factor in heterogenous tomato.

J Plant Res 2018 Nov 27. Epub 2018 Nov 27.

Department of Biological Science, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara, 630-0101, Japan.

The jasmonate-responsive transcription factor ERF189 in tobacco (Nicotiana tabacum) and its ortholog JRE4 in tomato (Solanum lycopersicum) regulate a series of biosynthetic genes involved in the nicotine and steroidal glycoalkaloid pathways. In tobacco, QUINOLINATE PHOSPHORIBOSYL TRANSFERASE 2 (NtQPT2) is regulated by ERF189; however, we found that the tomato QPT gene is not regulated by JRE4. Here, we explored whether and how NtQPT2 is regulated in a heterogenous tomato host. Read More

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November 2018

Novel therapeutics in the treatment of hairy cell leukemia variant.

Leuk Res 2018 Dec 5;75:58-60. Epub 2018 Nov 5.

University of Missouri, 1 Hospital Dr, McHaney Hall, Columbia, MO 65212, USA. Electronic address:

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December 2018
1 Read

'Nano on micro' hierarchical porous all carbon structures: an insight into interfacial interactions with bacteria.

Phys Chem Chem Phys 2018 Dec;20(47):29847-29855

Directorate of Nanomaterials and Technologies, DMSRDE, GT Road, Kanpur, India-13.

Micron long carbon nanofibers (CNFs) were grown on porous carbon beads to give an active surface for rapid immobilization of guest molecules. The fabrication of nanostructures using a catalytic route involving chemical vapour deposition on a porous substrate was accomplished by the controlled synthesis of iron nanoclusters on the surface of porous carbon beads. The challenge of catalyst nanoparticle diffusion into the porous substrate was addressed by using iron coordinated ligand complexes and optimizing the loading percentage of metal salts onto beads. Read More

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December 2018
2 Reads

Engineering "designer" glycomodules for boosting recombinant protein secretion in tobacco hairy root culture and studying hydroxyproline-O-glycosylation process in plants.

Plant Biotechnol J 2018 Nov 22. Epub 2018 Nov 22.

Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR, 72401, USA.

The key technical bottleneck for exploiting plant hairy root cultures as a robust bioproduction platform for therapeutic proteins has been low protein productivity, particularly low secreted protein yields. To address this, we engineered novel hydroxyproline (Hyp)-O-glycosylated peptides (HypGPs) into tobacco hairy roots to boost the extracellular secretion of fused proteins and to elucidate Hyp-O-glycosylation process of plant cell wall Hyp-rich glycoproteins. HypGPs representing two major types of cell wall glycoproteins were examined: an extensin module consisting of 18 tandem repeats of "Ser-Hyp-Hyp-Hyp-Hyp" motif or (SP4) and an arabinogalactan protein module consisting of 32 tandem repeats of "Ser-Hyp" motif or (SP) . Read More

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November 2018
1 Read

Datura innoxia plants hydroponically-inoculated with Agrobacterium rhizogenes display an enhanced growth and alkaloid metabolism.

Plant Sci 2018 Dec 11;277:166-176. Epub 2018 Sep 11.

Plant Biology & Innovation Laboratory, BIOPI EA3900-UPJV/SFR Condorcet FR CNRS 3417, Université de Picardie Jules Verne, 33 rue Saint Leu, F-80039, Amiens, France. Electronic address:

Background: The production of secondary metabolites through the culture of entire plants is of great interest. Soilless culture, such as hydroponics, enables the control of plant growth and metabolism. Specific environmental conditions must be developed to maximize the productivity of medicinal plants used as efficient natural bioreactors. Read More

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December 2018
2 Reads

Cortactin expression in non-Hodgkin B-cell lymphomas: a new marker for the differential diagnosis between chronic lymphocytic leukemia and mantle cell lymphoma.

Hum Pathol 2018 Nov 17. Epub 2018 Nov 17.

General Pathology & Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.

Cortactin is a cytoskeletal-remodeling adaptor protein, playing an oncogenic role in solid tumors. Little is known on Cortactin expression in non-Hodgkin B-cell lymphomas (B-NHL). The present study aimed to characterize Cortactin expression in B-NHL and to assess its role in the differential diagnosis of such entities. Read More

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November 2018
1 Read

[Hypertrichosis cubiti in a girl with precocious puberty: Case report].

Arch Argent Pediatr 2018 Dec;116(6):e765-e768

Hospital de Cabueñes, Gijón, Asturias, España.

Hypertrichosis cubiti is a localized increase in hair density, length and thickness. It is an uncommon and benign entity with very few patients described in the medical literature (more or less than half a hundred). Half of the described patients associate other defects or malformations and the other half are purely aesthetic cases. Read More

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December 2018
2 Reads

Cats use hollow papillae to wick saliva into fur.

Proc Natl Acad Sci U S A 2018 Dec 19;115(49):12377-12382. Epub 2018 Nov 19.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405;

The cat tongue is covered in sharp, rear-facing spines called papillae, the precise function of which is a mystery. In this combined experimental and theoretical study, we use high-speed film, grooming force measurements, and computed tomography (CT) scanning to elucidate the mechanism by which papillae are used to groom fur. We examine the tongues of six species of cats from domestic cat to lion, spanning 30-fold in body weight. Read More

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December 2018
2 Reads

The thermoregulation system and how it works.

Handb Clin Neurol 2018 ;156:3-43

Thermoregulation and Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States. Electronic address:

Heat exchange processes between the body and the environment are introduced. The definition of the thermoneutral zone as the ambient temperature range within which body temperature (T) regulation is achieved only by nonevaporative processes is explained. Thermoreceptors, thermoregulatory effectors (both physiologic and behavioral), and neural pathways and T signals that connect receptors and effectors into a thermoregulation system are reviewed. Read More

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January 2018
1 Read

Soybean CCA1-like MYB transcription factor GmMYB133 modulates isoflavonoid biosynthesis.

Biochem Biophys Res Commun 2018 Dec 15;507(1-4):324-329. Epub 2018 Nov 15.

College of Plant Science, Jilin University, Changchun, 130062, Jilin, China. Electronic address:

MYB transcription factors play important roles in the regulation of phenylpropanoid biosynthesis. However, the knowledge regarding the roles of CCA1-like MYBs in phenylpropanoid pathway is limited in plants. Previously, we identified 54 CCA1-like proteins in soybean. Read More

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December 2018
4 Reads

Modified Posterolateral Approach for Pterygium Colli.

J Craniofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Pterygium colli is a congenital deformity associated with malformation syndromes. Various surgical procedures have been reported, but these procedures have advantages and disadvantages. The modified posterolateral approach has been reported as a new surgical procedure for pterygium colli. Read More

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November 2018
1 Read

Preparation-Free Measurement of Event-Related Potential in Oddball Tasks From Hairy Parts Using Candle-Like Dry Microneedle Electrodes.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:4685-4688

This paper reports successful measurement of even-related potential (ERP) using candle-like dry microneedle electrodes, which can acquire high-quality electroencephalogram (EEG) from hairy parts without any pretreatment. In our previous work, we successfully measured spontaneous EEG activity and its application to assess the stress state of the subjects. ERPs originate from electrophysiological response to stimulus and are one of the most important indices to capture the cognitive and sensory activities. Read More

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T-Cell Large Granular Lymphocytic Leukemia - Case Reports.

Acta Clin Croat 2018 Jun;57(2):362-365

Department of Hematology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Read More

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June 2018
2 Reads

Bioreactor-based advances in plant tissue and cell culture: challenges and prospects.

Crit Rev Biotechnol 2018 Nov 15:1-15. Epub 2018 Nov 15.

g Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences , Universiti Putra Malaysia , Serdang , Selangor DE 43400 UPM , Malaysia.

Bioreactors are engineered systems capable of supporting a biologically active situation for conducting aerobic or anaerobic biochemical processes. Stability, operational ease, improved nutrient uptake capacity, time- and cost-effectiveness, and large quantities of biomass production, make bioreactors suitable alternatives to conventional plant tissue and cell culture (PTCC) methods. Bioreactors are employed in a wide range of plant research, and have evolved over time. Read More

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November 2018
1 Read

[Erdheim-Chester disease : An important differential diagnosis and its main symptoms].

Z Rheumatol 2018 Nov 14. Epub 2018 Nov 14.

Medizinische Klinik 3 - Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Deutschland.

Background: During the last 3 years 4 patients were admitted to this hospital with a wide variety of different symptoms, in whom Erdheim-Chester disease (ECD) was diagnosed via different diagnostic pathways.

Objective: Based on four clinical cases of ECD and using additional information from the literature, this article presents the symptoms of ECD. Furthermore, similarities and differences in comparison to important rheumatological differential diagnoses are presented. Read More

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November 2018
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Comparison of elicitor-based effects on metabolic responses of Taxus × media hairy roots in perfluorodecalin-supported two-phase culture system.

Plant Cell Rep 2018 Nov 7. Epub 2018 Nov 7.

Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha Str, 02-097, Warsaw, Poland.

Key Message: Two lines of Taxus × media hairy roots harbouring or not the TXS transgene demonstrated diverse gene expression and taxane yield during cultivation in PFD-supported two liquid-phase culture system. Two lines of Taxus × media hairy roots were subjected to single or twice-repeated supplementation with methyl jasmonate, sodium nitroprusside, L-phenylalanine, and sucrose feeding. One line harboured transgene of taxadiene synthase (ATMA), while the second (KT) did not. Read More

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November 2018
4 Reads

A toolbox for nodule development studies in chickpea: a hairy-root transformation protocol and an efficient laboratory strain of Mesorhizobium sp.

Mol Plant Microbe Interact 2018 Nov 6. Epub 2018 Nov 6.

National Institute of Plant Genome Research , Aruna Asaf Ali Marg , New Delhi-110067 , New Delhi, New Delhi, India , 110067 ;

Mesorhizobium sp. produces root nodules in chickpea. Chickpea and model legume Medicago truncatula are members of inverted repeat lacking clade (IRLC). Read More

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November 2018
3 Reads

Hairy Cell Leukemia: Retrospective Analysis of Demographic Data and Outcome of 203 Patients from 12 Medical Centers in Israel.

Anticancer Res 2018 Nov;38(11):6423-6429

The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

Background/aim: In this retrospective study, we summarized the national Israeli experience with hairy cell leukemia (HCL) in a large cohort of patients with a long follow-up.

Patients And Methods: Demographic data, and relevant laboratory and clinical parameters were analyzed, emphasizing the outcome after first-line treatment with cladribine.

Results: Data on 203 patients was collected from 12 medical centers during 1985-2015. Read More

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November 2018
3 Reads

Sertoli-immature spermatids disengagement during testis regression in the armadillo.

Reproduction 2018 Oct 1. Epub 2018 Oct 1.

S Garagna, Biologia e Biotecnologie "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.

In Nature, mammalian seasonal breeders undergo spermatogenetic arrest during the non-breeding season. In the large hairy armadillo Chaetophractus villosus, testis regression initiates with immature post-meiotic germ cells sloughing into the tubule lumen and continues with the death of the remaining spermatocytes. At the end of the regression period, only spermatogonia and Sertoli cells persist in the seminiferous epithelium. Read More

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October 2018
2 Reads

Enhancing Phenotyping and Molecular Analysis of Plant Root System Using Ultrasound Aeroponic Technology.

Curr Protoc Plant Biol 2018 Dec 31;3(4):e20078. Epub 2018 Oct 31.

Center for Plant Science Innovation, Department of Agronomy and Horticulture, Beadle Center, University of Nebraska-Lincoln, Lincoln, Nebraska.

Several plant growth systems are available to enhance the observation of the root system (e.g., hydroponic and aeroponic plant growth systems, use of transparent soils, etc. Read More

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December 2018

The light-induced transcription factor FtMYB116 promotes accumulation of rutin in Fagopyrum tataricum.

Plant Cell Environ 2018 Oct 30. Epub 2018 Oct 30.

Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing, China.

Tartary buckwheat (Fagopyrum tataricum) not only provides a supplement to primary grain crops in China but also has high medicinal value, by virtue of its rich content of flavonoids possessing antioxidant, anti-inflammatory, and anticancer properties. Light is an important environmental factor that can regulate the synthesis of plant secondary metabolites. In this study, we treated tartary buckwheat seedlings with different wavelengths of light and found that red and blue light could increase the content of flavonoids and the expression of genes involved in flavonoid synthesis pathways. Read More

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October 2018
7 Reads

Hairy polyps: A new case presentation and a pathogenetic hypothesis.

Laryngoscope 2018 Oct 29. Epub 2018 Oct 29.

Department of Otolaryngology and Communication Enhancement.

Hairy polyps are benign lesions found in the oropharynx or nasopharynx that are thought to be present at birth and can lead to upper airway obstruction in infants. Also known as naso-oropharyngeal choristoma, they are increasingly viewed as aggregates of bigeminal tissue, likely from the first or second branchial arches, found in aberrant locations. They are benign lesions that are usually successfully treated by surgical excision. Read More

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October 2018

Touch-induced pupil size reflects stimulus intensity, not subjective pleasantness.

Exp Brain Res 2018 Oct 29. Epub 2018 Oct 29.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.

Interpersonal touch is known to influence human communication and emotion. An important system for interpersonal touch is the C-tactile (CT) system, which is activated by a soft stroke on hairy skin with a velocity of 1-10 cms. This system been proposed to play a unique role in hedonic valence and emotion of touch. Read More

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October 2018

The AP2/ERF transcription factor SmERF1L1 regulates the biosynthesis of tanshinones and phenolic acids in Salvia miltiorrhiza.

Food Chem 2019 Feb 28;274:368-375. Epub 2018 Aug 28.

Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China; Institute of Plant Biotechnology, College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, PR China. Electronic address:

Tanshinones and phenolic acids are two important metabolites synthesized by the traditional Chinese medicinal plant Salvia miltiorrhiza. There is increasing market demand for these compounds. Here, we isolated and functionally characterized SmERF1L1, a novel JA (Jasmonic acid)-responsive gene encoding AP2/ERF transcription factor, from Salvia miltiorrhiza. Read More

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February 2019
2 Reads

Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.

Food Funct 2018 Nov;9(11):5607-5620

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.

Non-Camellia tea and herbal medicine help prevent the development of diabetes and other metabolic diseases. Previous studies revealed that Coreopsis tinctoria (CT) flower tea increases insulin sensitivity and, in some high-fat diet (HFD)-fed rats, even prevents hepatic metabolic disorders. However, the molecular mechanisms by which CT improves insulin resistance are not known. Read More

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November 2018
4 Reads

MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice.

Int J Mol Med 2019 Jan 24;43(1):91-102. Epub 2018 Oct 24.

Department of Neurosurgery, Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P.R. China.

Alzheimer's disease (AD) is a chronic neurodegenerative disease that often occurs at a slow pace yet deteriorates with time. MicroRNAs (miRs) have been demonstrated to offer novel therapeutic hope for disease treatment. The aim of the present study was to investigate the effect of miR‑98 on amyloid β (Aβ)‑protein production, oxidative stress and mitochondrial dysfunction through the Notch signaling pathway by targeting hairy and enhancer of split (Hes)‑related with YRPW motif protein 2 (HEY2) in mice with AD. Read More

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January 2019
1 Read

A Comparison between Video and Still Imagery as a Methodology to Determine Southern Hairy-Nosed Wombat () Burrow Occupancy Rates.

Animals (Basel) 2018 Oct 23;8(11). Epub 2018 Oct 23.

School of Biological Science, University of Adelaide, L3 Oliphant Bldg, North Terrace, Adelaide, SA 5005, Australia.

Broad-scale abundance estimates of the southern hairy-nosed wombat population use a proxy measure based on counting the number of active burrows, which is multiplied by an index of 'wombats/active burrow'. However, the extant indices were calculated in the 1980s, prior to the use of calicivirus to control rabbits, and used invasive monitoring methods which may have affected the results. We hypothesise that the use of video might provide a logistically simple, non-invasive means of calculating updated indices. Read More

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October 2018

Gene expression patterns determine the differential numbers of dorsocentral macrochaetes between M. domestica and D. melanogaster.

Genesis 2018 Oct 25. Epub 2018 Oct 25.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

The evolutionary differences in sensory bristle patterns on the thorax of dipterans are an excellent model for studying the patterns of evolutionary development. We observed that Drosophila melanogaster has two pairs of the large bristles, called macrochaetes, in the dorsocentral (DC) region of the notum, while Musca domestica retains six DC macrochaetes. To explore possible mechanism by which these two dipteran species have different numbers of DC bristles, we compared the corresponding protein sequences, the gene expression levels and the spatial expression patterns of five genes (scute, pnr, ush, hairy and emc) for bristle development between two species. Read More

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October 2018

Moxetumomab Pasudotox: First Global Approval.

Authors:
Sohita Dhillon

Drugs 2018 Nov;78(16):1763-1767

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Moxetumomab pasudotox-tdfk (LUMOXITI™), an anti CD22 recombinant immunotoxin, has been developed by MedImmune and its parent company AstraZeneca for the treatment of hairy cell leukaemia. The product, discovered at the National Cancer Institute, is an optimised version of immunotoxin CAT-3888. Moxetumomab pasudotox is composed of the Fv fragment of an anti-CD22 monoclonal antibody fused to a 38 kDa fragment of Pseudomonas exotoxin A, PE38. Read More

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November 2018
1 Read

Overexpression of SmbHLH10 enhances tanshinones biosynthesis in Salvia miltiorrhiza hairy roots.

Plant Sci 2018 Nov 31;276:229-238. Epub 2018 Jul 31.

Institute of Soil and Water Conservation, CAS & MWR, Yangling 712100, China; University of Chinese Academy of Sciences, Beijing 100049, China; College of Life Sciences, Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China; Tasly R&D Institute, Tasly Holding Group Co. Ltd, Tianjin 300410, China. Electronic address:

The bHLH transcription factors have important role in regulation of plant growth, development, and secondary metabolism. Tanshinones are the major pharmaceutical components present in Salvia miltiorrhiza Bunge. It has been reported that bHLHs have functions in terpenoids biosynthesis. Read More

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November 2018
3 Reads

An integrated experimental and theoretical study on the optical properties of uniform hairy noble metal nanoparticles.

Nanoscale 2018 Oct 22. Epub 2018 Oct 22.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

We report a viable route to plasmonic nanoparticles with well-controlled sizes, shapes, and compositions. A series of monodisperse Ag and Au nanoparticles capped with polystyrene chains (i.e. Read More

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October 2018
1 Read

Methylated flavones of the hairy root culture Scutellaria baicalensis.

J Plant Physiol 2018 Oct 11;231:277-280. Epub 2018 Oct 11.

Federal Scientific Center of the East Asia Terrestrial Biodiversity FEB RAS, 690022, 159 Stoletiya ave., Vladivostok, Russia; Vladivostok State University of Economics and Service, 690002, 41 Gogol st., Vladivostok, Russia.

Perennial plants in northern Dauria (Zabaikalsky region) grow in low temperatures in winter and in a dry hot summer. The prairies of northern Dauria are rich in a variety of medicinal herbs, including S. baicalensis, which has roots that are in demand for traditional Chinese medicine. Read More

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October 2018
6 Reads

The Increase of Triterpene Saponin Production Induced by -Anethole in Hairy Root Cultures of .

Molecules 2018 Oct 17;23(10). Epub 2018 Oct 17.

Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-151 Lodz, Poland.

In vitro cultivation is an effective way to increase pharmaceutical production. To increase ginsenoside production in hairy root cultures of American ginseng, the present study uses -anethole as an elicitor. The content of nine triterpene saponins was determined: Rb1, Rb2, Rb3, Rc, Rd, Rg1, Rg2, Re and Rf. Read More

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October 2018
6 Reads

Linezolid-induced black hairy tongue.

Acta Biomed 2018 Oct 8;89(3):408-410. Epub 2018 Oct 8.

Thoracic Surgery, Department of Medicine and Surgery, University Hospital of Parma.

Black hairy tongue (BHT) is a self-limiting disorder characterized by abnormal hypertrophy and elongation of filiform papillae on the surface of the tongue. The exact mechanism of drug-induced BHT is unknown. Several factors have been implicated and included smoking or chewing tobacco, drinking alcohol, poor oral hygiene and antibiotics such as tetracyclines and penicillins. Read More

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October 2018
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New Hairy Cell Leukemia Therapy.

Authors:
Rebecca Voelker

JAMA 2018 Oct;320(15):1528

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October 2018
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Secondary malignancies after treatment with single-agent vemurafenib in two patients with refractory hairy cell leukemia.

Leuk Lymphoma 2018 Oct 15:1-3. Epub 2018 Oct 15.

a Division of Hematology-Oncology , Scripps Clinic , La Jolla , CA , USA.

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October 2018
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Surface Structuring and Water Interactions of Nanocellulose Filaments Modified with Organosilanes toward Wearable Materials.

ACS Appl Nano Mater 2018 Sep 3;1(9):5279-5288. Epub 2018 Aug 3.

Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16300, Aalto 00076, Finland.

Colloidal dispersions of cellulose nanofibrils (CNFs) are viable alternatives to cellulose II dissolutions used for filament spinning. The porosity and water vapor affinity of CNF filaments make them suitable for controlled breathability. However, many textile applications also require water repellence. Read More

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September 2018
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