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Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging.

Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.

Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More

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December 2018
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Gonadotropin- and Adrenocorticotropic Hormone-Independent Precocious Puberty of Gonadal Origin in a Patient with Adrenal Hypoplasia Congenita Due to DAX1 Gene Mutation - A Case Report and Review of the Literature: Implications for the Pathomechanism.

Horm Res Paediatr 2018 Dec 11:1-10. Epub 2018 Dec 11.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.

Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.

Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More

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December 2018

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More

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December 2018
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Efficacy of topical dithranol (Dithrocream ) in the treatment of alopecia areata: a retrospective case series.

Authors:
A Daunton M Harries

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

The Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, U.K.

Topical dithranol is an alternative therapy to topical diphencyprone for extensive AA, with the advantage that it can be applied at home. It is also safe in children and has low risk for use during pregnancy. Its precise mechanism of action is unknown, but it is plausible that the local cytokine profile induced by its irritant effect "compete" with the inflammatory milieu incited during the inflammatory cell attack on hair follicles. Read More

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December 2018

Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. Read More

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December 2018

De novo and inherited loss-of-function variants of ATP2B2 are associated with rapidly progressive hearing impairment.

Hum Genet 2018 Dec 8. Epub 2018 Dec 8.

Hearing and Genes, Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

ATP2B2 encodes the PMCA2 Ca pump that plays an important role in maintaining ion homeostasis in hair cells among others by extrusion of Ca from the stereocilia to the endolymph. Several mouse models have been described for this gene; mice heterozygous for loss-of-function defects display a rapidly progressive high-frequency hearing impairment. Up to now ATP2B2 has only been reported as a modifier, or in a digenic mechanism with CDH23 for hearing impairment in humans. Read More

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December 2018

Papillae formation on Arabidopsis leaf trichomes requires the function of Mediator tail subunits 2, 14, 15a, 16, and 25.

Planta 2018 Dec 7. Epub 2018 Dec 7.

School of Biological Sciences, Illinois State University, Normal, IL, 61790, USA.

Main Conclusion: Arabidopsis Mediator subunits 2, 14, 15a, 16, and 25 are required for papillae development on the trichome cell wall surface. Arabidopsis leaf hairs exhibit raised protrusions, termed papillae, on their cell wall surfaces. Here, we show that the glassy hair mutant, glh2, exhibits trichomes with an approximate 11-fold decrease in papillae density on their surfaces in comparison to wild type. Read More

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December 2018

A patient with pilomatricoma in the parotid region: case report and review of the literature.

Rom J Morphol Embryol 2018 ;59(3):917-926

Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;

Pilomatricoma is a benign skin tumor originating from the matrix cells of the hair follicles. Sometimes, its diagnosis can be difficult, especially in the preauricular region, where in the differential diagnosis, in addition to other dermal and subcutaneous masses, primary and secondary parotid gland tumor lesions must be also considered. A 34-year-old female was referred to our Institution with a right preauricular swelling over 12 months, which enlarged in the last two months. Read More

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January 2018

Dry skin and the use of leave-on products in nursing care: A prevalence study in nursing homes and hospitals.

Nurs Open 2019 Jan 27;6(1):189-196. Epub 2018 Sep 27.

Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science Charité - Universitätsmedizin Berlin Berlin Germany.

Aims: To describe the prevalence of dry skin in nursing homes and hospitals and to describe relationships between topical skincare interventions and dry skin.

Design: Two multicentre descriptive cross-sectional prevalence studies.

Methods: The studies were performed in German nursing homes and hospitals in 2015 and 2016. Read More

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January 2019

(Trichocomaceae): A Natural, Eco-Friendly Mycoinsecticide for Control of Malaria, Filariasis, Dengue Vectors and Its Toxicity Assessment Against an Aquatic Model Organism .

Front Pharmacol 2018 26;9:1355. Epub 2018 Nov 26.

Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Salem, India.

Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adulticidal, and smoke toxicity effect of extract against three mosquito species, namely , and (Diptera: Culicidae). The isolated fungal strain was identified as (GenBank accession no: KX694148. Read More

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November 2018

Comparative (Quantitative and Qualitative) Analysis of Three Different Reagents for Preparation of Platelet-Rich Plasma for Hair Rejuvenation.

Authors:
Sukhbir Singh

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):127-131

Resplendent the cosmetic studio, R-9, GK Part 1, New Delhi-48.

Objective: The aim of this study was to compare the quantity and quality of platelets in platelet-rich plasma (PRP) samples prepared using three different reagents, namely, ethylenediaminetetraacetic acid (EDTA), sodium citrate, and acid citrate dextrose-A (ACD-A) solution.

Materials And Methods: A prospective study was carried out in which all the 50 patients who attended the outpatient department for hair rejuvenation were enrolled for the study. All the patients had a history of hair fall with diffuse thinning of hair, Norwood Grades 2 and 3. Read More

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December 2018

The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.

Front Cell Neurosci 2018 23;12:445. Epub 2018 Nov 23.

Section on Sensory Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.

Mechanosensory hair cells of the inner ear transduce auditory and vestibular sensory input. Hair cells are susceptible to death from a variety of stressors, including treatment with therapeutic drugs that have ototoxic side effects. There is a need for co-therapies to mitigate drug-induced ototoxicity, and we showed previously that induction of heat shock proteins (HSPs) protects against hair cell death and hearing loss caused by aminoglycoside antibiotics in mouse. Read More

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November 2018

Erector spinae block for postoperative analgesia following axillary hidradenitis suppurativa resection: a case report.

Local Reg Anesth 2018 15;11:87-90. Epub 2018 Nov 15.

Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA,

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the terminal hair follicle of the apocrine gland-bearing skin, presenting with inflamed nodules, abscesses, and sinus tracts. Autoimmune, genetic, and infectious factors have been implicated in its pathogenesis. HS can be managed medically using topical and systemic antibiotics and with tumor necrosis factor antibody therapy in severe cases. Read More

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November 2018

A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss.

Int J Nanomedicine 2018 14;13:7517-7531. Epub 2018 Nov 14.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China,

Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity.

Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs). Read More

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November 2018

Giant Axonal Neuropathy: Clinical, Radiological, and Genetic Features.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):304-308

Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

Introduction: Giant axonal neuropathy (GAN) is an inherited neurodegenerative disorder caused by mutations in the GAN gene. It affects both the central and peripheral nervous systems. We discuss clinical, electrophysiological, radiological and genetic features in three new unrelated patients with GAN. Read More

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December 2018

Antibiotic resistance is lower in Staphylococcus aureus isolated from antibiotic-free raw meat as compared to conventional raw meat.

PLoS One 2018 10;13(12):e0206712. Epub 2018 Dec 10.

Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States of America.

The frequent use of antibiotics contributes to antibiotic resistance in bacteria, resulting in an increase in infections that are difficult to treat. Livestock are commonly administered antibiotics in their feed, but there is current interest in raising animals that are only administered antibiotics during active infections. Staphylococcus aureus (SA) is a common pathogen of both humans and livestock raised for human consumption. Read More

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December 2018

PDL2 CD11b dermal dendritic cells capture topical antigen through hair follicles to prime LAP Tregs.

Nat Commun 2018 12 7;9(1):5238. Epub 2018 Dec 7.

Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Read More

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December 2018

Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.

Nat Commun 2018 Dec 10;9(1):5271. Epub 2018 Dec 10.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.

Natural hair colour within European populations is a complex genetic trait. Previous work has established that MC1R variants are the principal genetic cause of red hair colour, but with variable penetrance. Here, we have extensively mapped the genes responsible for hair colour in the white, British ancestry, participants in UK Biobank. Read More

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December 2018

Periocular Manifestations of Afatinib Therapy.

Ophthalmic Plast Reconstr Surg 2018 Dec 4. Epub 2018 Dec 4.

Oxford University Hospital, Headley Way, Headington, Oxford, United Kingdom.

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. Read More

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December 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

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October 2018

Simultaneous determination of methylphenidate and ritalinic acid in hair using LC-MS/MS.

Forensic Sci Int 2018 Nov 29;294:183-188. Epub 2018 Nov 29.

National Forensic Service, 139 Jiyang-ro, Yangcheon-Gu, Seoul 158-707, Republic of Korea.

Methylphenidate (MPH) is one of the most commonly prescribed stimulants for attention deficit hyperactivity disorder and its abuse is on the rise with its growing availability. Some analytical methods have been reported for the detection of MPH in hair. However, the concentration range of MPH as well as its metabolite, ritalinic acid (RA) in the hair of MPH abuse cases has not been reported. Read More

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November 2018

Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin.

Hear Res 2018 Nov 30;371:98-104. Epub 2018 Nov 30.

Sensorion, 375 Rue Du Professeur Blayac, 34080, Montpellier, France.

Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possible biomarker and provided proof of concept in noise- and cisplatin-induced hearing loss. Read More

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November 2018

Correlation and temporal variability of urinary biomarkers of chemicals among couples: Implications for reproductive epidemiological studies.

Environ Int 2018 Dec 5;123:181-188. Epub 2018 Dec 5.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Exposure to some environmental chemicals is ubiquitous and linked to a variety of adverse outcomes, including children's health. While few studies have assessed the contribution of both male and female exposures to children's health, understanding the patterns of couple's exposure is needed to understand their joint effects.

Objective: We assessed the correlation patterns between male and female partners' concentrations of 37 environmental chemical biomarkers. Read More

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December 2018

Arthropod venoms: Biochemistry, Ecology and Evolution.

Toxicon 2018 Dec 6. Epub 2018 Dec 6.

Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012. India. Electronic address:

Comprising of over a million described species of highly diverse invertebrates, Arthropoda is amongst the most successful animal lineages to have colonized aerial, terrestrial, and aquatic domains. Venom, one of the many fascinating traits to have evolved in various members of this phylum, has underpinned their adaptation to diverse habitats. Over millions of years of evolution, arthropods have evolved ingenious ways of delivering venom in their targets for self-defence and predation. Read More

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December 2018

Epilepsy and Neurodegeneration: Clues in the Hair and Blood Vessels!

J Pediatr 2018 Oct 24. Epub 2018 Oct 24.

Department of Radio Diagnosis and Imaging Postgraduate Institute of Medical Education and Research Chandigarh, India.

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October 2018

Transient Receptor Potential Vanilloid 4 is Expressed in Human Hair Follicles and Inhibits Hair Growth in Vitro.

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

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December 2018

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial.

Pregnancy Hypertens 2018 Oct 19;14:15-22. Epub 2018 May 19.

Obstetrics and Gynaecology, Universite de Sherbrooke, Canada. Electronic address:

Objectives: As a follow-up to the CHIPS trial (Control of Hypertension In Pregnancy Study) of 'less tight' (versus 'tight') control of maternal blood pressure in pregnancy, CHIPS-Child investigated potential developmental programming of maternal blood pressure control in pregnancy, by examining measures of postnatal growth rate and hypothalamic-pituitary adrenal (HPA) axis activation.

Methods: CHIPS follow-up was extended to 12 ± 2 months corrected post-gestational age for anthropometry (weight, length, head/waist circumference). For eligible children with consent for a study visit, we collected biological samples (hair/buccal samples) to evaluate HPA axis function (hair cortisol levels) and epigenetic change (DNA methylation analysis of buccal cells). Read More

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October 2018

3D-printed Wash Station with Integrated Anesthesia Delivery Manifold for High-throughput Depilation of Laboratory Mice.

J Am Assoc Lab Anim Sci 2018 Dec 7. Epub 2018 Dec 7.

Depilation (that is, hair removal) is a necessary prerequisite for many small animal surgeries and optical imaging experiments.Over-the-counter depilatory creams are widely used, owing to their efficacy, safety, and low rates of skin irritationand infection. However, the use of these creams is generally messy and time-consuming and generates considerable waste. Read More

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December 2018

Using human head lice to unravel neglect and cause of death.

Parasitology 2018 Dec 10:1-7. Epub 2018 Dec 10.

Ecology and Evolutionary Biology Section, School of Biological Sciences, University of Reading,Reading, RG6 6AS,UK.

Despite the common association of human lice with abandoned or neglected people, no procedure to assess pediculosis, aimed to detect signs of neglect, exists. Investigating the two most common forms of head louse infestation, regular and severe, we define lice-markers of neglect and develop a protocol and survey form to record and assess pediculosis. The study of head lice from a deceased victim of neglect helped unravel time-length since death, frequency of exposure to neglect and the cause and circumstances related to the death. Read More

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December 2018

An Evaluation of Hair, Oral Fluid, Earwax, and Nasal Mucus as Noninvasive Specimens to Determine Livestock Exposure to Teratogenic Lupine spp.

J Agric Food Chem 2018 Dec 7. Epub 2018 Dec 7.

The livestock industry in the western United States loses an estimated $500 million annually from livestock production losses due to poisonous plants. Poisoning of livestock by plants often goes undiagnosed because there is a lack of appropriate or available specimens for analysis. Lupinus species represent an important toxic plant in western North America that can be toxic and/or teratogenic to livestock species due to the quinolizidine alkaloids. Read More

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December 2018

Identification and molecular analysis of a lncRNA-HOTAIR transcript from secondary hair follicle of cashmere goat reveal integrated regulatory network with the expression regulated potentially by its promoter methylation.

Gene 2018 Dec 3. Epub 2018 Dec 3.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address:

The HOTAIR transcript is transcribed from the antisense strand within the HOXC gene cluster, and it is thought to play a role in regulating the inductive capacity of dermal papilla cells during the reconstruction of hair-follicle. In the current investigation, we firstly isolated and characterized a lncRNA-HOTAIR transcript from the secondary hair follicle of cashmere goat. Also, we analyzed its transcriptional pattern and methylation level of HOTAIR gene promoter in secondary hair follicle of cashmere goat during anagen and telogen stages. Read More

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December 2018
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Stem cells repurpose proliferation to contain a breach in their niche barrier.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Robin Neustein Laboratory of Mammalian Development and Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, United States.

Adult stem cells are responsible for life-long tissue maintenance. They reside in and interact with specialized tissue microenvironments (niches). Using murine hair follicle as a model, we show that when junctional perturbations in the niche disrupt barrier function, adjacent stem cells dramatically change their transcriptome independent of bacterial invasion and become capable of directly signaling to and recruiting immune cells. Read More

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December 2018
8.519 Impact Factor

Dermoscopic follow-up of therapeutic response in mantle cell lymphoma with secondary involvement of the scalp.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

The Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland.

The scalp is a potential location for both benign and malignant tumors. Lymphoproliferative diseases can involve the skin as a primary or secondary manifestation. Dermoscopy is a noninvasive diagnostic tool for rapid diagnosis, screening, and follow-up of the majority of skin tumors. Read More

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December 2018
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The relation between androgenetic thin hair diagnosed by trichoscope and benign prostatic hyperplasia.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Faculty of Medicine, Benha University, Benha, Egypt.

Background: Androgenetic alopecia carries a major cosmetic disfigurement and benign prostatic hyperplasia is associated with many urinary tract symptoms and both diseases are mediated by dihydrotestosterone.

Objectives: The study aimed to determine the relationship between hair diameter in androgenetic alopecia diagnosed, by trichoscope, to benign prostatic hyperplasia symptoms and signs.

Methods: Fifty androgenetic alopecia males and 50 normal males as control were included. Read More

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December 2018
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Dermoscopic evaluation of melanocytic nevi changes after photoepilation techniques: a prospective study.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.

Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.

Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.

Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More

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December 2018

Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Tufts Medical Center, Boston, MA.

Alopecia areata (AA) is a common autoimmune disease driven by Th1 cytokines characterized by non-scarring hair loss. Mouse models have demonstrated that IFN-γ-producing NKG2D+ CD8+ cytotoxic T lymphocytes (CTLs) are essential for disease pathogenesis, along with JAK-STAT dependent cytokines IFN-γ and IL-15, which induce autoreactive T cell activation. This article is protected by copyright. Read More

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December 2018
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Expression of class III Semaphorins and their receptors in the developing chicken (Gallus gallus) inner ear.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biological Sciences, Purdue University, West Lafayette, Indiana.

Class III Semaphorin (Sema) secreted ligands are known to repel neurites expressing Neuropilin (Nrp) and/or Plexin (Plxn) receptors. There is, however, a growing body of literature supporting that Sema signaling also has alternative roles in development such as synaptogenesis, boundary formation and vasculogenesis. To evaluate these options during inner ear development, we used in situ hybridization or immunohistochemistry to map the expression of Sema3D, Sema3F, Nrp1, Nrp2, and PlxnA1 in the chicken (Gallus gallus) inner ear from embryonic day (E)5 to E10. Read More

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December 2018
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Novel insights into molecular chaperone regulation of ribonucleotide reductase.

Curr Genet 2018 Dec 5. Epub 2018 Dec 5.

Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC, 28223, USA.

The molecular chaperones Hsp70 and Hsp90 bind and fold a significant proportion of the proteome. They are responsible for the activity and stability of many disease-related proteins including those in cancer. Substantial effort has been devoted to developing a range of chaperone inhibitors for clinical use. Read More

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December 2018

Author Correction: Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.

Nature 2018 Dec 5. Epub 2018 Dec 5.

Department of Anesthesiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

In Figs. 1e and 2g of this Letter, the labels 'actin' and 'VGLUT3', respectively, should have been in red instead of green font. This has been corrected online. Read More

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December 2018

The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival.

Cell Death Dis 2018 Dec 5;9(12):1180. Epub 2018 Dec 5.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.

Mutations in the GJB2 gene (which encodes Connexin26 (Cx26)) account for about a quarter of all cases of non-syndromic deafness. Previous studies have indicated that knockout (KO) of Gjb2 gene during early postnatal days can cause outer hair cell (OHC) loss in mouse models. However, the postnatal spatial distribution pattern of Cx26 in different types of supporting cells (SCs) and the role of such distributions for the survival of OHCs is still obscure. Read More

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December 2018

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Redox Biol 2018 Nov 20;20:544-555. Epub 2018 Nov 20.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Mitochondrial NADP-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency induces mitochondrial dysfunction and modulates auditory function, and investigated the protective potential of an antioxidant agent against reactive oxygen species (ROS)-induced cochlear damage in Idh2 knockout (Idh2) mice. Idh2 deficiency leads to damages to hair cells and spiral ganglion neurons (SGNs) in the cochlea and ultimately to apoptotic cell death and progressive sensorineural hearing loss in Idh2 mice. Read More

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November 2018
1 Read

Use of Modified Islanded Paramedian Forehead Flap for Complex Periocular Facial Reconstruction.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic Surgery, PGIMER, Chandigarh, India.

The paramedian forehead flap is a workhorse flap for reconstructing the nose and periorbital regions. Many variants are described including an islanded flap. However, eyebrow reconstruction is not usually performed with these flaps. Read More

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November 2018

Hair analysis to discriminate voluntary doping vs inadvertent ingestion of the aromatase inhibitor letrozole.

Drug Test Anal 2018 Dec 2. Epub 2018 Dec 2.

Department of Cardiac Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Letrozole is an aromatase inhibitor, used to treat post-menopausal women with hormone receptor-positive or unknown advanced breast cancer. It is prohibited in sport because it is used together with androgen anabolizing steroids to avoid their adverse effects. In case of adverse analytical finding, it may be important to distinguish between repetitive use due to voluntary administration and occasional use, possibly due to involuntary intake. Read More

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December 2018
1 Read