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    1 OF 60

    Graft versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss.
    Int J Trichology 2018 Mar-Apr;10(2):80-83
    Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.
    A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA). Read More

    Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata.
    Stem Cell Res Ther 2018 May 15;9(1):141. Epub 2018 May 15.
    Department of Biology, Laboratory of Therapeutic Innovation, Faculty of Sciences 2, Lebanese University, Fanar, Lebanon.
    Background: Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. Read More

    Scrotal Rejuvenation.
    Cureus 2018 Mar 13;10(3):e2316. Epub 2018 Mar 13.
    Department of Dermatology, University of California, San Diego.
    Genital rejuvenation is applicable not only to women (vaginal rejuvenation) but also to men (scrotal rejuvenation). There is an increased awareness, reflected by the number of published medical papers, of vaginal rejuvenation; however, rejuvenation of the scrotum has not received similar attention in the medical literature. Scrotal rejuvenation includes treatment of hair-associated scrotal changes (alopecia and hypertrichosis), morphology-associated scrotal changes (wrinkling and laxity), and vascular-associated scrotal changes (angiokeratomas). Read More

    Use of homeobox gene expression patterns to determine anatomical regions of origin for body surface tissues derived from adult mice.
    J Tissue Eng Regen Med 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
    Anatomical regions of the skin have distinct functions and anatomical characteristics, including thicker or thinner epidermis, more or fewer hair follicles, and lighter or darker skin. For a better therapeutic outcome of skin transplantation, site-specific characteristics of grafted tissues need to be taken into account in terms of their functionality and beauty. However, there is no method for evaluating positional information of epidermal cells. Read More

    Diffuse large B-cell lymphoma chemotherapy reveals a combined immunodeficiency syndrome in cartilage hair hypoplasia.
    Swiss Med Wkly 2018 04 24;148:w14606. Epub 2018 Apr 24.
    CHU de Caen, Department of Internal Medicine and Clinical Immunology, Caen, France.
    Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodeficiency after receiving an adriamycin-based chemotherapy regimen followed by autologous stem cell transplantation. Read More

    Hidradenitis suppurativa/acne inversa: a prospective bacteriological study of 46 patients and review of the literature.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle that usually involves specific anatomic areas which are partially occluded, have a higher density of eccrine and apocrine sweat glands and a higher pH. These characteristics could promote the superinfection of certain group of bacteria. We aimed to describe the bacteria that can be isolated from hidradenitis lesions and to establish a correlation between bacteriological results and clinical data. Read More

    A case of a rare variant of Klinefelter syndrome, 47,XY,i(X)(q10).
    Andrologia 2018 Apr 17:e13024. Epub 2018 Apr 17.
    Department of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan.
    Klinefelter syndrome is a condition in which a male patient has one Y chromosome and one or more extra X chromosomes. It is the most common sex chromosome disorder. Klinefelter syndrome is distinguished by many clinical features, such as infertility, high gonadotropin and low testosterone levels, increased height, and sparse body and facial hair. Read More

    Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury.
    J Neurotrauma 2018 Apr 30. Epub 2018 Apr 30.
    1 Department of Physiology, University of Kentucky , Lexington, Kentucky.
    Our previous studies reported that pharmacological maintenance of mitochondrial bioenergetics after experimental spinal cord injury (SCI) provided functional neuroprotection. Recent evidence indicates that endogenous mitochondrial transfer is neuroprotective as well, and, therefore, we extended these studies with a novel approach to transplanting exogenous mitochondria into the injured rat spinal cord. Using a rat model of L1/L2 contusion SCI, we herein report that transplantation of exogenous mitochondria derived from either cell culture or syngeneic leg muscle maintained acute bioenergetics of the injured spinal cord in a concentration-dependent manner. Read More

    In Vitro Survival of Mesenchymal Stem Cells is Enhanced in Artificial Endolymph with Moderately High Concentrations of Potassium.
    Stem Cells Dev 2018 May 7. Epub 2018 May 7.
    3 Department of Cell Biology, Center of Excellence in Tissue Engineering, Key Laboratory of Beijing, Institute of Basic Medical Sciences and School of Basic Medicine , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China .
    While mesenchymal stem cells (MSCs) are promising candidates for inner ear hair cell regeneration, to date, there have been no convincing reports indicating whether MSCs can survive in the cochlea for more than a few weeks, as the high levels of potassium (K) in the endolymph (EL) are thought to be toxic to transplanted stem cells. For conditioning the EL for MSC transplantation, we conducted this in vitro study to examine the effects of artificial EL with altered K concentration levels, in the range of 5-153.8 mM, on proliferation, apoptosis, and morphological changes in MSCs derived from various human tissues. Read More

    Localized Telogen Effluvium Following Hair Transplantation.
    Ann Dermatol 2018 Apr 21;30(2):214-217. Epub 2018 Feb 21.
    Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
    Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, major surgery, emotional stress, abrupt diet, chronic illness, or the taking of certain medication pills. Two patients who both recalled an operational history of hair transplantation visited our department with their frontal and both temporal hair loss. Read More

    Hair Follicle-Associated Pluripotent (HAP) Stem Cells in Gelfoam Histoculture for Use in Spinal Cord Repair.
    Methods Mol Biol 2018 ;1760:145-162
    AntiCancer, Inc., San Diego, CA, USA.
    The stem cell marker, nestin, is expressed in the hair follicle, both in cells in the bulge area (BA) and the dermal papilla (DP). Nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells of both the BA and DP have been previously shown to be able to form neurons, heart muscle cells, and other non-follicle cell types. The ability of the nestin-expressing HAP stem cells from the BA and DP to repair spinal cord injury was compared. Read More

    Chronic cutaneous graft-versus-host disease in children: A report of 14 patients from a tertiary care pediatric dermatology clinic.
    Pediatr Dermatol 2018 May 14;35(3):343-353. Epub 2018 Mar 14.
    Dermatopathology Unit, As'ad Al-Hamad Dermatology Center, Kuwait.
    Background/objectives: Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option for many life-threatening disorders in children. Chronic graft-versus-host disease (cGVHD) is a significant complication of HSCT, and its treatment is challenging. Skin is the most common organ affected in cGVHD, with protean manifestations posing a challenge in diagnosis and management. Read More

    Fluorescent polydopamine nanoparticles as a probe for zebrafish sensory hair cells targeted in vivo imaging.
    Sci Rep 2018 Mar 13;8(1):4393. Epub 2018 Mar 13.
    Hazards Monitoring BNT Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.
    Fluorescent polydopamine nanoparticles (FPNPs) are prepared via the ethylenediamine (EDA)-induced degradation of as-prepared non-fluorescent polydopamine (PDA) and used for targeted bioimaging. The reductive treatment of PDA in the presence of EDA yields fluorescent precipitates, inspiring us to seek various biological approaches to preparing FPNPs with excellent optical and biocompatible properties. Moreover, we firstly found that FPNPs selectively label neuromast hair cells in the lateral line of zebrafish, their applications as a reliable fluorescent indicator to investigate the neuromast hair cells, to in turn determine the viability of hair cells, was demonstrated. Read More

    A 61-year-old man with erythematous forearm papules three months after liver transplantation.
    Transpl Infect Dis 2018 Mar 7:e12869. Epub 2018 Mar 7.
    Division of Infectious Diseases, The University of North Carolina, Chapel Hill, NC, USA.
    A 61-year-old Caucasian man presented with papules on his left forearm and hand three months after liver transplantation: images from physical exam, pathology, and microbiology are presented. Skin biopsy confirmed the presence of fungal elements within the hair shaft, which is consistent with Majocchi granuloma, also known as nodular granulomatous perifolliculitis. A combination of fungal culture, microscopic morphology, and gene sequencing was used to identify the causative organism. Read More

    Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model.
    Lasers Med Sci 2018 Apr 21;33(3):637-645. Epub 2018 Feb 21.
    Department of Dermatology, The Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
    Activation of the Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis and hair growth. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth in numerous clinical studies, in which 655-nm red light was found to be most effective and practical for stimulating hair growth. We evaluated whether 655-nm red light + light-emitting diode (LED) could promote human hair growth by activating Wnt/β-catenin signaling. Read More

    Pubic Hair Restorative Surgery Using Grafts Harvested by the Nonshaven Follicular Unit Extraction Technique.
    Dermatol Surg 2018 Feb 15. Epub 2018 Feb 15.
    Both authors are affiliated with Dana Plastic Surgery Clinic, Gangnamgu, Seoul, Korea.
    Background: Pubic atrichosis or hypotrichosis is quite common among Korean women. Although Korean people are increasingly opening up to Western culture, pubic hair transplantation is still pursued for cultural reasons. However, many hesitate to undergo restorative surgery because follicular unit strip surgery would leave a linear donor scar, preventing patients from hiding their surgical history. Read More

    Standardization of SMP Procedure and Its Impact On Outcome.
    J Cutan Aesthet Surg 2017 Jul-Sep;10(3):145-149
    Department of Dermatology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
    Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Read More

    Gold thread implantation promotes hair growth in human and mice.
    Lab Anim Res 2017 Dec 31;33(4):291-297. Epub 2017 Dec 31.
    Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
    Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains largely unknown due to lack of investigation. When we implanted gold thread and Happy Lift™ in human patient for facial lifting, we unexpectedly found an increase of hair regrowth in spite of no use of hair growth medications. Read More

    An efficient method for eccrine gland isolation from human scalp.
    Exp Dermatol 2018 Feb 2. Epub 2018 Feb 2.
    The Centre for Dermatology Research, MAHSC, University of Manchester, Manchester, UK.
    We describe a simple and efficient method to isolate eccrine sweat glands from the human scalp. This method is inspired by the hair graft harvesting method used in hair transplantation. Based on the recently described anatomical relationship between the scalp hair follicle and the eccrine gland, we have found that scalp follicular unit grafts are an excellent eccrine gland isolation source, especially for the coiled component. Read More

    Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease.
    Blood 2018 May 23;131(18):2074-2085. Epub 2018 Jan 23.
    Department of Hematology, Faculty of Medicine, Hokkaido University, Sapporo, Japan; and.
    Graft-versus-host disease (GVHD) is the major complication after allogeneic stem cell transplantation (SCT). Emerging evidence indicates that GVHD leads to injury of intestinal stem cells. However, it remains to be investigated whether skin stem cells could be targeted in skin GVHD. Read More

    Parietal scalp is another affected area in female pattern hair loss: an analysis of hair density and hair diameter.
    Clin Cosmet Investig Dermatol 2018 29;11:7-12. Epub 2017 Dec 29.
    Department of Medicine, Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Purpose: Female pattern hair loss (FPHL) is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL. Read More

    The use of minoxidil in the treatment of male and female androgenetic alopecia: a story of more than 30 years.
    G Ital Dermatol Venereol 2018 Feb;153(1):102-106
    Unit of Dermatology, Department of Medical and Transplantation Physiopathology, Ca' Granda Ospedale Maggiore Policlinico Foundation, University of Milan, Milan, Italy -
    Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. Read More

    Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis.
    J Invest Dermatol 2018 Jan 6. Epub 2018 Jan 6.
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA. Electronic address:
    Large excisional wounds in mice prominently regenerate new hair follicles (HFs) and fat, yet humans are deficient for this regenerative behavior. Currently, wound-induced regeneration remains a clinically desirable, but only partially understood phenomenon. We show that large excisional wounds in rats across seven strains fail to regenerate new HFs. Read More

    Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients.
    J Audiol Otol 2018 Apr 5;22(2):105-109. Epub 2018 Jan 5.
    Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
    Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. Read More

    Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids.
    Cell Rep 2018 Jan;22(1):242-254
    Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
    The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in basic research studies or in vitro drug testing. To date, generation of hair follicles in vitro has only been possible using primary cells isolated from embryonic skin, cultured alone or in a co-culture with stem cell-derived cells, combined with in vivo transplantation. Read More

    A Hairy Situation: Laser Hair Removal after Oral Reconstruction.
    Ann Otol Rhinol Laryngol 2018 Mar 31;127(3):205-208. Epub 2017 Dec 31.
    4 Department of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
    Objectives: To present a case series of 4 patients who underwent postoperative hair removal using the long-pulsed Alexandrite or Nd:YAG laser following intraoral cutaneous flap reconstruction.

    Methods: Patients underwent epilation in dermatology clinic with long-pulsed Alexandrite or Nd:YAG lasers, spaced 8 weeks apart, until hair removal was achieved.

    Results: All patients achieved improvement in hair removal regardless of initial flap donor site with significant improvement in quality of life and minimal side effects. Read More

    Scaffold-Assisted Artificial Hair Implantation in a Rat Model.
    JAMA Facial Plast Surg 2017 Dec 28. Epub 2017 Dec 28.
    Department of Head and Neck Surgery, UCLA Medical Center, Los Angeles, California.
    Importance: Current treatments for alopecia with autograft hair transplantation face limitations that may preclude complete hair restoration and leave patients with donor site scars. Scaffold assisted artificial hair implantation as demonstrated in a rat model may provide an adjunct for hair restoration without donor site morbidity.

    Objective: To design and create porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (ePTFE) hair-bearing scaffolds and evaluate their biocompatibility in a rat model. Read More

    Use of low-level laser therapy in treatment of the androgenic alopecia, the first systematic review.
    J Cosmet Laser Ther 2017 Dec 11:1-6. Epub 2017 Dec 11.
    a Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Dermatology , Wuhan , China.
    Alopecia is a common disease affecting more than half of the world total number of people. Alopecia exists in different types, but one of the most common of these types is the Androgenic Alopecia which has affected approximately 51% of the total number of males ranging between the age bracket of 40 years and 75 years. This type of alopecia is more common in females who are above the age of 65 years and above. Read More

    Spontaneous hair follicle germ (HFG) formation in vitro, enabling the large-scale production of HFGs for regenerative medicine.
    Biomaterials 2018 Feb 6;154:291-300. Epub 2017 Nov 6.
    Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan. Electronic address:
    Hair follicle morphogenesis is triggered by reciprocal interactions between hair follicle germ (HFG) epithelial and mesenchymal layers. Here, we developed a method for large-scale preparation of HFGs in vitro via self-organization of cells. We mixed mouse epidermal and mouse/human mesenchymal cells in suspension and seeded them in microwells of a custom-designed array plate. Read More

    A Novel Multi-Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals.
    J Drugs Dermatol 2017 Nov;16(11):s141-s148

    Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. Read More


    New-Generation Therapies for the Treatment of Hair Loss in Men.
    Dermatol Clin 2018 Jan 12;36(1):63-67. Epub 2017 Oct 12.
    Department of Dermatology, Weill Cornell Medicine, New York, NY, USA; Department of Dermatology, University of Buffalo, Buffalo, NY, USA. Electronic address:
    Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants. Read More

    Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants.
    PLoS One 2017 30;12(10):e0187183. Epub 2017 Oct 30.
    Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, South Holland, the Netherlands.
    Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type of therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory neurons and glial cells, and (3) can easily be harvested in relatively high numbers. However, HFBSCs have never been used for this purpose. Read More

    Optimizing Male Periorbital Rejuvenation.
    Dermatol Surg 2017 Nov;43 Suppl 2:S196-S202
    *Charlotte Plastic Surgery, Charlotte, North Carolina; †Hofstra University Northwell School of Medicine, New York, New York; ‡Dallas Plastic Surgery Institute, Dallas, Texas.
    Background: Facial rejuvenation continues to be an increasing trend among males. The periorbital region deserves special mention given the overall differences in aesthetics between sexes.

    Objective: To examine the aesthetics of the upper eyelid, lower eyelid, lateral canthus, and brow with respect to male periorbital rejuvenation. Read More

    Hair Transplantation Controversies.
    Dermatol Surg 2017 Nov;43 Suppl 2:S158-S162
    *Private Practice, Dermatology, New York, New York; †Weill Cornell Medical Center, New York, New York; ‡Heights Dermatology, Brooklyn, New York; §Tulane Health Sciences Center, New Orleans, Louisiana; ‖Private Practice, Old Metairie Dermatology, Metairie, Louisiana.
    Background: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss.

    Objective: To review some current controversies in hair transplant surgery. Read More

    Hair Transplantation in Migraine Headache Patients.
    Plast Reconstr Surg Glob Open 2017 Sep 21;5(9):e1503. Epub 2017 Sep 21.
    SO-EP Aesthetic & Plastic Surgery Clinic, Kayseri, Turkey.
    Background: Migraine headache is a primary neurologic disease affecting millions of people worldwide. As a consequence, quality of life is diminished, productivity suffers (through loss of work force), and treatment costs are substantial. The occurrence rate in the general population is quite high, with women accounting for 3 of every 4 cases. Read More

    Traction alopecia: A neglected entity in 2017.
    Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):644-649
    Department of Dermatology, School of Medicine, Cardiff University, Cardiff, CF, UK.
    Traction alopecia was first described in 1904 but is still a cause of scarring hair loss in young women worldwide. It is unique in being initially a reversible then an irreversible (scarring) form of alopecia. Linked to tightly-pulled hairstyles, it is seen across all races. Read More

    Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study.
    Am J Transplant 2018 May 22;18(5):1220-1230. Epub 2017 Nov 22.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Read More

    Management of syndromic diarrhea/tricho-hepato-enteric syndrome: A review of the literature.
    Intractable Rare Dis Res 2017 Aug;6(3):152-157
    Aix Marseille Université, INSERM, Génétique Médicale et Génomique Fonctionnelle (GMGF), UMRS 910, Marseille, France.
    Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare disease linked to the loss of function of either TTC37 or SKIV2L, two components of the SKI complex. It is characterized by a combination of 9 signs (intractable diarrhea, hair abnormalities, facial dysmorphism, immune abnormalities, IUGR/SGA, liver abnormalities, skin abnormalities, congenital heart defect and platelet abnormalities). We present a comprehensive review of the management of SD/THE and tested therapeutic regimens. Read More

    Camouflaging Cleft Lip Scar Using Follicular Unit Extraction Hair Transplantation Combined with Autologous Fat Grafting.
    Plast Reconstr Surg 2018 01;141(1):148-151
    Konya, Turkey From the Department of Plastic Surgery, Selcuk University Medical Faculty.
    Background: The scar that occurs after cleft lip surgery poses a serious cosmetic problem. One of the methods used to solve this problem in adult male patients is hair transplantation. However, satisfactory results with this method cannot always be achieved because of possible graft loss. Read More

    FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.
    J Clin Immunol 2017 Nov 21;37(8):751-758. Epub 2017 Sep 21.
    Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Via S. Pansini, 5, 80131, Naples, Italy.
    Since the discovery of FOXN1 deficiency, the human counterpart of the nude mouse, a growing body of evidence investigating the role of FOXN1 in thymus and skin, has been published. FOXN1 has emerged as fundamental for thymus development, function, and homeostasis, representing the master regulator of thymic epithelial and T cell development. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, although the underlying molecular mechanisms still remain to be fully elucidated. Read More

    Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant.
    ACG Case Rep J 2017 13;4:e107. Epub 2017 Sep 13.
    Alpert Medical School, Brown University, Providence, RI.
    infections can be life-threatening but are increasingly being treated successfully with fecal microbiota transplantation (FMT). We report two patients with alopecia universalis who developed subsequent hair regrowth after FMT for treatment of recurrent infections. Gut microbiota may have immunomodulatory effects in autoimmune conditions such as alopecia areata, and further study may elucidate disease mechanisms and lead to alternative treatment options for these patients for whom treatment options are currently limited. Read More

    Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation.
    Int J Trichology 2017 Jul-Sep;9(3):127-129
    Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
    Hair transplantation, a generally regarded as a safe surgical modality for the treatment of androgenetic alopecia, is not without its potential risks and complications. A case of an extensive keloid formation at donor site following follicular unit extraction is discussed. Hair transplant surgeons should be aware of this significant potential complication, especially in patients having previous keloidal tendencies to avoid such disastrous outcomes. Read More

    Accelerated epithelialization and improved wound healing metrics in porcine full-thickness wounds transplanted with full-thickness skin micrografts.
    Wound Repair Regen 2017 09 11;25(5):816-827. Epub 2017 Oct 11.
    Dental and Craniofacial Trauma Research Directorate, United States Army Institute of Surgical Research, Fort Sam Houston, Texas.
    Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Read More

    Genetic DNA profile in urine and hair follicles from patients who have undergone allogeneic hematopoietic stem cell transplantation.
    Sci Justice 2017 Sep 13;57(5):336-340. Epub 2017 May 13.
    Unit of Legal Medicine, University of Cantabria, IDIVAL, Cardenal Herrera Oria s/n, 39011 Santander, Spain.
    Biological samples from patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT) constitute a challenge for individual identification. In this study we analyzed the genetic profiles (by the amplification of 15 autosomic STRs) of HSCT patients found in different types of samples (blood, hair and urine) that may be the source of DNA in civil or criminal forensic cases. Our results show that while in hair follicles the donor component was not detected in any patient, thus being a reliable source of biological material for forensic identification, mixed chimerism was detected in urine samples from all patient, and no correlation was found between the time elapsed from the transplant and the percentage of chimerism. Read More

    Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering.
    J Cosmet Dermatol 2017 Sep 8. Epub 2017 Sep 8.
    Private Practice, Dermatology OPD, QU for Health Professional, DermNet NZ's, Tripoli, Tarabulus, Libya.
    The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage. Read More

    Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients.
    Acta Derm Venereol 2018 Jan;98(1):77-81
    Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. E-mail:
    Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Read More

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