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Cureus 2020 Apr 28;12(4):e7878. Epub 2020 Apr 28.

Life Sciences, Biofort Corp., Guaynabo, PRI.

Treatment of refractory palmar-plantar vitiligo is particularly challenging because the skin in these regions has a limited supply of follicle-derived melanocytic stem cells. Autologous hair transplantation monotherapy is effective in some forms of vitiligo through the provision of melanocytic stem cells. CO laser followed by exposure to light (i. Read More

Postepy Dermatol Alergol 2020 Apr 6;37(2):274-276. Epub 2020 May 6.

Department of Paediatric Surgery and Urology, Wroclaw Medical University, Wroclaw, Poland.

J Cosmet Dermatol 2020 May 23. Epub 2020 May 23.

Department of Otolaryngology/Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Early use of follicular unit excision (FUE) as a method of hair transplantation was limited by high rates of hair follicle transection. This hurdle has been overcome by innovative methods, punch shapes, and devices. With the vast array of tools available, it can be difficult for hair transplant surgeons to choose the best option for their practices. Read More

Stem Cell Reports 2020 May 6. Epub 2020 May 6.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

Sensorineural hearing loss and vestibular dysfunction are caused by damage to neurons and mechanosensitive hair cells, which do not regenerate to any clinically relevant extent in humans. Several protocols have been devised to direct pluripotent stem cells (PSCs) into inner ear hair cells and neurons, which display many properties of their native counterparts. The efficiency, reproducibility, and scalability of these protocols are enhanced by incorporating knowledge of inner ear development. Read More

Stem Cells Int 2020 29;2020:9148310. Epub 2020 Jan 29.

Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 512100, China.

Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplantation is reported to promote skin healing, endothelial cell transformation, and vascular formation. Read More

JIMD Rep 2020 May 9;53(1):80-82. Epub 2020 Apr 9.

Department of Pediatrics, Nutrition and Metabolic Diseases The Children's Memorial Health Institute Warsaw Poland.

In 2016, 11 male patients were reported with immunodeficiency and hepatic, gastric and (in some) neurological disease due to X-linked ATP6AP1 deficiency (ATP6AP1-CDG). In 2018, three other patients were reported with additional features: connective tissue abnormalities, sensorineural hearing loss, hyperopia, glomerular and tubular dysfunction, exocrine pancreatic insufficiency and altered amino acid and lipid metabolism. We here present a follow-up of three reported siblings showing progression of deafness to total hearing loss, progressive loss of hair up to alopecia, chestnut skin and, at last follow-up, in some of them proteinuria. Read More

J Invest Dermatol 2020 May 5. Epub 2020 May 5.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. Electronic address:

Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory dermatosis characterized by abscesses, deep-seated nodules, sinus tracts and fibrosis in skin lesions around hair follicles of the axillary, inguinal and anogenital regions. While the exact pathogenesis remains poorly defined, clear evidence suggests that HS is a multifactorial inflammatory disease characterized by innate and adaptive immune components. Bioactive lipids are important regulators of cutaneous homeostasis, inflammation as well as resolution of inflammation. Read More

J Cosmet Laser Ther 2020 May 7:1-4. Epub 2020 May 7.

The Department of Dermatology, West China Hospital of Sichuan University, Chengdu, China.

The rise in the incidence of androgenetic alopecia (AGA) in China has increased the inclination toward hair transplantation. To calculate the optimum density of hair follicles needed covering both the hairless area and the safe donor area (SDA), 119 male patients with AGA were recruited into this multicenter investigation. We evaluated the mean diameter and the number of hair follicles (HFs) and follicular units (FUs) in the SDA of AGA. Read More

J Cosmet Dermatol 2020 Apr 28. Epub 2020 Apr 28.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China.

Background: Large area androgenic alopecia patients seeking hair transplantation treatment has become common. FUE Megasession has become a choice for more and more people. Long-term in vitro preservation of hair follicles during FUE Megasession has become a new challenge. Read More

Neurosci Lett 2020 Jun 25;729:135010. Epub 2020 Apr 25.

Department of Otology and Skull Base Surgery, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai, 200031, People's Republic of China. Electronic address:

Loss of inner ear hair cell (HC) is an irreversible process in mammals and is the most common cause of human hearing and balance disorders especially in the elderly. Cell therapy based on highly scalable generation of HC linage and inner ear transplantation is one of the most promising therapeutic approaches for HC impairment. For fibroblast is quite abundant and readily available in human body, it is an ideal endogenous cell source to generate HC lineage for transplantation purpose. Read More

J Cosmet Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Faculty of Medicine, Department of Dermatology, Aksaray University, Aksaray, Turkey.

Background: Beard and mustache are important components of body image. Beard transplantation is the procedure to restore congenital absence or inefficient growth of beard and mustache.

Objectives: The aim of the study is to report our results and experience in beard transplantation. Read More

Methods Mol Biol 2020 ;2154:165-173

Mediteknia Hair Transplant Clinic and Hair Lab, Gran Canaria, Canary Islands, Spain.

The isolation of eccrine sweat glands from human skin has always been a difficult task. The human scalp contains thousands of eccrine glands. Recently, the close anatomic relationship of the eccrine gland with the scalp hair follicle has been described. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):xi-xii

Facial Plastic and Reconstructive Surgery, Harvard Medical School, Massachusetts Eye and Ear, 325 Charles Street, Boston, MA 02114, USA. Electronic address:

Facial Plast Surg Clin North Am 2020 May;28(2):237-241

Private Practice, Miami, FL, USA. Electronic address:

In the field of hair restoration, there has been a significant increase in demand with patients for facial hair transplantation procedures. Modern techniques in hair transplantation allow for facial hair transplantation and for the attainment of natural-appearing results. Facial hair transplantation is a subspecialty within hair restoration with many gratifying benefits for the patients as well as for the hair restoration surgeon. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):225-235

Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA; Chicago Hair Institute (Private Practice), 1S280 Summit Suite C-4, Oakbrook Terrace, IL 60181, USA. Electronic address:

Most complications associated with hair transplant surgery are usually preventable and most often arise as a consequence of poor planning or faulty surgical technique. Patients should be evaluated for having realistic goals and a pattern that is amenable to aesthetic restoration. A good treatment plan must consider the potential for future hair loss. Read More

Facial Plast Surg Clin North Am 2020 May 2;28(2):197-203. Epub 2020 Mar 2.

Philip Frost Department of Dermatology and Cosmetic Surgery, University of Miami, 6280 Sunset Drive, Suite 504, Miami, FL 33143, USA.

As an alternative to hair transplantation for lowering the overly high hairline, hairline-lowering/forehead-reduction surgery has several advantages, including unsurpassed density and immediate results. Appropriate candidates for this surgery must have a stable frontal hairline (thus excluding most men) and a fairly to very mobile scalp that will permit sufficient advancement to warrant this more "invasive" approach. The main objective of this surgery is the lowering of the hairline. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):189-196

905 Fifth Avenue, New York, NY 10021, USA.

Contemporary hair transplant surgery creates natural appearing transplanted hair. The procedure is performed as an outpatient under local anesthesia. Donor harvesting can be performed by either elliptical donor harvesting or follicular unit extraction. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):177-179

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Johns Hopkins University, 601 North Caroline Street, Baltimore, MD 21287, USA. Electronic address:

Hair loss can be a debilitating condition, especially for individuals who already have chronic underlying medical conditions that complicate the treatment of hair loss. This article addresses the challenges posed by scarring alopecia in hair-loss treatment and the evidence-based practices that exist for hair transplantation in scarring alopecia. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):169-176

Medical School, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, Serbia.

Hair transplantation, or hair restoration surgery (HRS) remains the only method to consistently restore hair in those experiencing pattern hair loss as well as hair loss from most other causes. HRS has been significantly improved with the development of follicular unit extraction, later renamed follicular unit excision, or FUE. This allows the surgeon to harvest grafts from the donor area without leaving a scar. Read More

Facial Plast Surg Clin North Am 2020 May;28(2):161-167

Spokane Center for Facial Plastic Surgery, 217 West Cataldo Avenue, Third Floor, Spokane, WA 99201, USA. Electronic address:

Hair transplant is a powerful and reliable procedure that provides a natural and high-impact result. This procedure can be used to restore scalp hair, eyebrow hair, beard hair, body hair, or areas of hair loss due to scarring. The hair transplant techniques of the past (hair plugs, scalp reductions) have etched a negative impression of hair restoration surgery in the public memory. Read More

Intest Res 2020 Apr 22. Epub 2020 Apr 22.

Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.

Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders and other conditions like metabolic syndrome and functional gastrointestinal disorders. Amongst various therapies targeting gut microbiome, fecal microbiota transplantation (FMT) is becoming a focus in the public media and peer reviewed literature. We have been using FMT for induction of remission in patients with moderate to severe active ulcerative colitis (UC) and also for subsequent maintenance of remission. Read More

J Cosmet Dermatol 2020 Apr 18. Epub 2020 Apr 18.

Department of Chemistry, Govt Sadiq College Women University, Bahawalpur, Pakistan.

Background: Local anesthetic is one of the major ways to obtain satisfactory anesthesia in majority of plastic surgical procedures.

Objectives: To compare the effect on pain while injecting buffered vs nonbuffered local anesthetic.

Materials And Methods: The single-blind, split-scalp study was conducted in 25 patients undergoing first hair transplant surgery after informed consent and ethics committee approval using two solutions. Read More

Sci Rep 2020 Apr 7;10(1):5995. Epub 2020 Apr 7.

Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Montevideo, Uruguay.

Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of nonsyndromic recessive auditory neuropathy spectrum disorder in humans. We report the generation of the first large animal model of OTOF mutations using the CRISPR system associated with different Cas9 components (mRNA or protein) assisted by single strand oligodeoxynucleotides (ssODN) to induce homology-directed repair (HDR). Zygote microinjection was performed with two sgRNA targeting exon 5 and 6 associated to Cas9 mRNA or protein (RNP) at different concentrations in a mix with an ssODN template targeting HDR in exon 5 containing two STOP sequences. Read More

Stem Cell Res Ther 2020 Apr 3;11(1):143. Epub 2020 Apr 3.

Key Laboratory of Reproductive Medicine of Guangdong Province, The First Affiliated Hospital and School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

Background: Factors such as poor engraftment, retention, and survival of the transplanted stem cells are deemed to limit their therapeutic efficacy for wound regeneration. Hence, it is necessary to explore these issues in order to resolve them. In this study, we aim to investigate the role of Pluronic F-127 (PF-127) hydrogel plus antioxidant sodium ascorbyl phosphate (SAP) in enhancing Wharton's jelly mesenchymal stem cell (WJMSC)-mediated effectiveness on full-thickness skin wound healing in mice. Read More

Stem Cell Res Ther 2020 Apr 3;11(1):144. Epub 2020 Apr 3.

State Key Laboratory of Chemical Oncogenomics, and Shenzhen Key Laboratory of Health Sciences and Technology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.

Background: Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic hair follicle formation are poorly investigated. In this study, we aimed to understand the interactions between Epi-SCs and SKPs during skin organoid formation and to uncover key signal pathways crucial for de novo hair follicle regeneration.

Methods: To track their fate after transplantation, Epi-SCs derived from neonatal C57BL/6 mice were labeled with tdTomato, and SKPs were isolated from neonatal C57BL/6/GFP mice. Read More

Adv Wound Care (New Rochelle) 2020 05 19;9(5):264-276. Epub 2020 Mar 19.

Division of Plastic Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, California.

Epidermal CD34 stem cells located in the hair follicle (HF) bulge area are capable of inducing HF neogenesis and enhancing wound healing after transplantation. In this study, we observed CD34 cells derived from blood directly participate in dermal regeneration during full-thickness excisional wound healing. We isolated and expanded a subset of hematopoietic stem cell (HSC)-like precursor cells from the peripheral blood of adult mice with the surface markers: CD34, leucine rich repeat containing G protein-coupled receptor 5 (LGR5), CD44, c-kit, lineage negative (lin), and E-cadherin. Read More

J Tissue Eng Regen Med 2020 May 27;14(5):723-735. Epub 2020 Mar 27.

Department of Orthopedic Surgery, Affiliated Jiangnan Hospital, Zhejiang Chinese Medical University, Hangzhou, China.

Repair of large skin defects caused by burns, trauma, or tumor operations is a clinical challenge. Hair follicle stem cells (HFSCs) are involved in epithelialization of wounds, formation of new hair follicles and promote vascularization in the newly formed skin, and human acellular amniotic membrane (hAAM) is a promising scaffold for skin substitute. Here, we investigated the ability of rat HFSCs (rHFSCs) combined with an hAAM to repair full thickness skin defects in nude mice. Read More

Dermatol Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Emergency Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey Department of Emergency Medicine, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey Department of Emergency Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

J Cosmet Dermatol 2020 Mar 12. Epub 2020 Mar 12.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran.

Background: Androgenetic alopecia (AGA) is widely characterized as the main reason of hair loss which most of the time it has been reported in adults regarding dermatological consultation. Also, it is broadly believed that the progressive miniaturization of hair follicles could be usually different at the age of onset.

Aims: Over the last decade, detecting and understanding newer genetic basis in AGA lead to provide better therapeutic approaches. Read More

Mitochondrion 2020 Mar 6;52:125-134. Epub 2020 Mar 6.

Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Spinal cord injury (SCI), a multifactorial disease, can lead to irreversible motor and sensory disabilities. Cell therapy in combination with pharmacological agents can be a promising approach to attenuate SCI damages. Epidermal neural crest stem cells (EPI-NCSCs) extracted from bulge hair follicle in adults are attractive candidates due to the possibility of autologous transplantation. Read More

Adv Chronic Kidney Dis 2020 01;27(1):56-66

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation. Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities can plague kidney transplant recipients. By 10 years, virtually all allografts will have evidence of CNI nephrotoxicity. Read More

Dermatol Surg 2020 Mar 4. Epub 2020 Mar 4.

Department of Otolaryngology/Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado.

Background: Follicular unit excision (FUE) and follicular unit transplantation using strip surgery (FUT) are the dominant graft harvest methods in hair transplantation. The increase in the demand for FUE has reignited the debate of the relative superiority of the 2 methods.

Objective: To present a critical comparison of FUE and FUT graft harvesting techniques. Read More

Proc Natl Acad Sci U S A 2020 Mar 24;117(10):5339-5350. Epub 2020 Feb 24.

Robin Neustein Laboratory of Mammalian Development and Cell Biology, The Rockefeller University, New York, NY 10065;

Aging manifests with architectural alteration and functional decline of multiple organs throughout an organism. In mammals, aged skin is accompanied by a marked reduction in hair cycling and appearance of bald patches, leading researchers to propose that hair follicle stem cells (HFSCs) are either lost, differentiate, or change to an epidermal fate during aging. Here, we employed single-cell RNA-sequencing to interrogate aging-related changes in the HFSCs. Read More

J Plast Surg Hand Surg 2020 Jun 25;54(3):172-176. Epub 2020 Feb 25.

Shinwa Clinic, Tokyo, Japan.

Donor site morbidity is an important consideration for follicular unit excision (FUE). We examined 103 male patients with adult androgenic alopecia. Patients were divided into three groups (Good, Fair, and Poor) based on visual assessment of the donor site. Read More

J Eur Acad Dermatol Venereol 2020 Feb 20. Epub 2020 Feb 20.

Department of Dermatology, Great Ormond Street Hospital for Children, London, UK.

Background: Paediatric localized scleroderma is a severe inflammatory disorder associated with tissue atrophy, often leading to disability. Assessing disease activity and response to treatment has always been challenging and remains an important difficulty in clinical practice.

Objectives: To investigate prospectively the efficacy of systemic treatment with corticosteroids and methotrexate in children with localized scleroderma and the validity of infrared thermography, laser Doppler flowmetry and high-frequency ultrasound in assessing disease activity. Read More

J Cosmet Dermatol 2020 Feb 13. Epub 2020 Feb 13.

Plastic and Hair Restorative Surgeon, Hair Transplant Institute, Islamabad, Pakistan.

Objectives: To measure the effects of previous Follicular Unit Transplantation (FUT) procedure.

Materials And Methods: The study was conducted in a private hair transplant clinic after obtaining informed consent. Only those patients were included who had a previous strip harvest surgery (FUT) and opted for Follicular Unit Excision/Extraction (FUE) procedure. Read More

Laryngoscope 2020 Feb 11. Epub 2020 Feb 11.

Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, U.S.A.

Objective: Evolving hair transplantation (HT) techniques have offered new possibilities for hair restoration. However, the role of HT in patients with frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) remains unclear. This study aims to evaluate the outcomes and temporal relationship of HT in this population. Read More

Cell Tissue Res 2020 Feb 8. Epub 2020 Feb 8.

Optical Molecular Imaging, Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.

Traumatic brain injury (TBI) is a devastating event for which current therapies are limited. Stem cell transplantation may lead to recovery of function via different mechanisms, such as cell replacement through differentiation, stimulation of angiogenesis and support to the microenvironment. Adult hair follicle bulge-derived stem cells (HFBSCs) possess neuronal differentiation capacity, are easy to harvest and are relatively immune-privileged, which makes them potential candidates for autologous stem cell-based therapy. Read More

J Invest Dermatol 2020 Feb 5. Epub 2020 Feb 5.

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China. Electronic address:

It is known that Lgr4 plays an important role in hair follicle development, but the impact of Lgr4 on hair cycle is still unclear. In the present study, we have found that K14-Cre-mediated skin epithelia-specific deletion of Lgr4 results in delayed anagen entry during physiological hair cycle and compromised hair follicle regeneration upon transplantation. We show that while Lgr4 deletion does not appear to affect the number of quiescent hair follicle stem cells, it leads to reduced numbers of Lgr5 and actively proliferating stem cells in the hair follicles. Read More

Skin Appendage Disord 2020 Jan 11;6(1):41-43. Epub 2019 Sep 11.

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.

Autologous fat grafting (AFG) is a common procedure, which gains popularity for a large number of indications, mainly for reshaping and filling of contour defects. It is considered a safe procedure, with only uncommon and mild complications. Here we report on a 60-year-old female patient who developed excess hair growth on both cheeks 1 month following facial AFG done in conjunction with a facelift. Read More

Dermatol Surg 2020 Jan 31. Epub 2020 Jan 31.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Orphanet J Rare Dis 2020 Feb 1;15(1):36. Epub 2020 Feb 1.

Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland.

Background: Sensenbrenner syndrome, which is also known as cranioectodermal dysplasia (CED), is a rare, autosomal recessive ciliary chondrodysplasia characterized by a variety of clinical features including a distinctive craniofacial appearance as well as skeletal, ectodermal, liver and renal anomalies. Progressive renal disease can be life-threatening in this condition. CED is a genetically heterogeneous disorder. Read More

Urologiia 2019 12(6):87-91

Department of Uroandrology of the Russian Childrens Clinical Hospital, Moscow, Russia.

Aim: Buccal mucosa and preputial skin grafts are used for staged urethroplasty in proximal forms of hypospadias in children. Aim of our study was to carry out a comparative histological analysis of preputial skin and buccal mucosa.

Method: s and materials: Histological analysis of urethral tissue samples from 10 patients with proximal forms of hypospadias was conducted. Read More

J Cutan Aesthet Surg 2019 Oct-Dec;12(4):250-254

Department of Dermatology, Eugenix Hair Sciences, Gurugram, Haryana, India.

Background: Techniques of hair transplantation are evolving with time both in terms of use of better methods of graft harvestment and implantation. The result of the procedure ultimately depends on the tenderness with which grafts are handled.

Aims: The aim of this study was to evaluate efficacy and feasibility of using implanter in premade slits for implantation of the graft. Read More

J Cutan Aesthet Surg 2019 Oct-Dec;12(4):215-222

Department of Dermatology, DermaClinix-The Complete Skin and Hair Solution Center, New Delhi, India.

Background: In advanced grade baldness (Norwood 5-7), hair restoration has been considered difficult due to the donor recipient area mismatch. In this article, we have given a comprehensive methodical approach to manage these cases.

Objective: To assess the outcome and challenges faced with follicular unit extraction (FUE) and to plan a successful management in advanced grade baldness in 820 cases of androgenic alopecia. Read More

Ann Dermatol Venereol 2020 Feb 20;147(2):131-134. Epub 2020 Jan 20.

Service de dermatologie, hôpital universitaire Farhat Hached, Sousse, Tunisie.

Background: Severe combined immunodeficiency (SCID) is a the most severe form of primary immunodeficiency and is highly heterogeneous. We report an atypical form of SCID revealed by exfoliative erythroderma.

Patients And Methods: A 3-month-old boy, born to consanguineous parents, was admitted to the dermatology department with exfoliative erythroderma associated with eczematous patches and alopecia of the scalp, eyelashes, and eyebrows, but with no lymphadenopathy or hepatosplenomegaly. Read More

J Invest Dermatol 2020 Jan 21. Epub 2020 Jan 21.

Laboratory of Biosignaling & Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, Leuven, Belgium. Electronic address:

Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a ubiquitously expressed nuclear protein that regulates functions of protein serine/threonine phosphatase-1 in cell proliferation and lineage specification. The role of NIPP1 in tissue homeostasis is not fully understood. This study shows that the selective deletion of NIPP1 in mouse epidermis resulted in epidermal hyperproliferation, a reduced adherence of basal keratinocytes, and a gradual decrease in the stemness of hair follicle stem cells, culminating in hair loss. Read More

J Dermatol Sci 2020 Feb 14;97(2):168-170. Epub 2020 Jan 14.

Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address: