Search Our Scientific Publications & Authors

Mol Ther 2019 Apr 2. Epub 2019 Apr 2.

CNRS UMR 7260, Aix-Marseille Université, Marseille, France; Laboratory of Bioengineering and Nanoscience, LBN, University of Montpellier, Montpellier, France. Electronic address:

Most cases of sensorineural deafness are caused by degeneration of hair cells. Although stem/progenitor cell therapy is becoming a promising treatment strategy in a variety of organ systems, cell engraftment in the adult mammalian cochlea has not yet been demonstrated. In this study, we generated human otic progenitor cells (hOPCs) from induced pluripotent stem cells (iPSCs) in vitro and identified these cells by the expression of known otic markers. Read More

Ann Hematol 2019 Apr 16. Epub 2019 Apr 16.

Department of Plastic, Reconstructive and Hand Surgery, University Hospital, Regensburg, Germany.

Refractory skin ulcers due to severe chronic graft-versus-host disease (cGVHD) remain to be associated with significant morbidity and mortality.We performed an allogeneic donor skin transplantation in seven adult patients after allogeneic hematopoietic stem cell transplantation for cGVHD-associated refractory skin ulcers. While four patients received a split skin graft (SSG), in one patient, a full thickness skin graft for two small refractory ulcers of the ankle was performed, and one patient received in vitro expanded donor keratinocyte grafts derived from hair roots of the original unrelated donor. Read More

Aesthetic Plast Surg 2019 Apr 11. Epub 2019 Apr 11.

Dana Plastic Surgery Clinic, Samju Building 10F, Gangnamdaero 606, Gangnam-gu, Seoul, 06038, Korea.

Patients undergoing secondary female hairline correction surgery present with dissatisfaction of various causes that require specific solutions. Satisfactory results following secondary revision surgery are achieved only after consideration of the reasons for the patient's dissatisfaction as well as specific factors regarding the state of the hairline, height and width of the forehead, and overall facial type; all of these must be considered when choosing the most suitable surgical method. In the present study, the authors used various surgical approaches according to the patient's characteristics and presenting symptoms in the performance of secondary hairline correction surgery and evaluated the adequacy of each method using a satisfaction survey. Read More

Indian J Plast Surg 2018 Sep-Dec;51(3):316-320

Department of Burns and Plastic Surgery, B.J. Medical College, Gujarat University, Ahmedabad, Gujarat, India.

Introduction: Temporal recession in male-pattern baldness is common. The method of marking of temporal point practiced worldwide, described by Walter P. Unger, does not help in marking temporal triangle border in Indian population. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):279-282

Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.

Griscelli syndrome is a rare autosomal recessive inherited disorder characterized by hypopigmentation, silver colored hair, and associated immunological deficiency, which proves fatal in the absence of timely intervention. Our patients diagnosed with Griscelli syndrome-2 presented with fever, hepatosplenomegaly, and deranged hematological and biochemical parameters. Both cases underwent detailed investigations comprising of hair mount microscopic examination, degranulation assay, and mutational studies. Read More

Cell Rep 2019 Apr;27(2):455-466.e5

Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; School of Medicine, Yokohama City University, Yokohama 236-0004, Japan. Electronic address:

Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels from vitiligo patients using a three-dimensional system with enhanced differentiation efficiency, which showed characteristics of human epidermal melanocytes with high sequence similarity and involved in multiple vitiligo-associated signaling pathways. Read More

Nat Protoc 2019 Apr 8. Epub 2019 Apr 8.

Laboratory for Organ Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.

Organ systems play essential roles in the physiological functions required for homeostasis. A 3D integumentary organ system (3D-IOS) comprises the skin and skin appendages such as hair follicles and sebaceous glands. This protocol describes how to induce the differentiation of murine induced pluripotent stem (iPS) cells into a 3D-IOS. Read More

J Am Acad Dermatol 2019 Apr 3. Epub 2019 Apr 3.

The Ronald O. Perelman Department of Dermatology, New York University, New York, New York 10016. Electronic address:

Background: Guidelines for the treatment of frontal fibrosing alopecia (FFA) are limited and literature on treatment modalities consists mostly of case reports and cohort studies.

Objectives: In this review, we sought to assess the response of medical therapy for FFA and propose a clinical approach to management.

Methods: A literature search for "frontal fibrosing alopecia" on PubMed returned 270 items. Read More

Facial Plast Surg Clin North Am 2019 May;27(2):227-232

Private Practice, Foundation for Hair Restoration, 6280 Sunset Drive, Suite 504, Miami, FL, USA.

Hair transplantation can play a complementary role in the spectrum of gender transformation procedures sought by transgender patients undergoing gender transformation surgery. The authors' clinic has seen an increase in the demand for hair restoration in transgender patients. Hairline lowering, eyebrow transplantation, and pubic hair transplantation can play roles for male-to-female transgender patients whereas beard hair transplantation and body hair transplantation can play integral roles for female-to-male patients seeking gender transformation surgery. Read More

Arch Plast Surg 2019 Mar 31;46(2):167-170. Epub 2019 Mar 31.

Department of Burn Reconstructive Surgery, Bestian Seoul Hospital, Seoul, Korea.

Full-thickness scalp burns secondary to hair coloring are rare; however, such defects can be large and complex reconstruction of hair-bearing tissue may be necessary. Many skin-stretching devices that use gradual traction have been applied to take advantage of the viscoelastic properties of the skin. A 21-year-old female patient was seen with a burn defect on her occipital scalp leading to exposed subcutaneous tissue after chemical application of hair coloring in a salon. Read More

Arch Plast Surg 2019 Mar 31;46(2):147-151. Epub 2019 Mar 31.

Dana Plastic Surgery Clinic, Seoul, Korea.

Background: Successful aesthetic plastic surgery is devoid of both unsightly scarring and postoperative disfigurement. Patients undergoing midface-lifting surgery are very often disconcerted by an altered side hairline, including sideburns, despite considerable amelioration of facial wrinkles. This study was conducted to identify an effective means of approaching an altered hairline and the unavoidable scarring arising from midface-lifting surgery. Read More

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea.

Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth, cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. Read More

Hear Res 2019 Mar 19;377:72-87. Epub 2019 Mar 19.

Centre for Stem Cell Biology and Department of Biomedical Sciences, University of Sheffield, Sheffield, S10 2TN, United Kingdom. Electronic address:

Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for 'cell replacement therapy', in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor. In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. Read More

Adv Exp Med Biol 2019 ;1130:165-180

Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, People's Republic of China.

Permanent hearing loss was considered which cannot be cured since cochlear hair cells and primary afferent neurons cannot be regenerated. In recent years, due to the in-depth study of stem cell and its therapeutic potential, regenerating auditory sensory cells is made possible. By using two strategies of endogenous stem cell activation and exogenous stem cell transplantation, researchers hope to find methods to restore hearing function. Read More

Sci Rep 2019 Mar 26;9(1):5198. Epub 2019 Mar 26.

Department of Plastic and Reconstructive Surgery, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

The hair follicle serves as a melanocyte reservoir for both hair and skin pigmentation. Melanocyte stem cells (MelSCs) and melanocyte progenitors reside in the bulge/sub-bulge region of the lower permanent portion of the hair follicle and play a vital role for repigmentation in vitiligo. It would be beneficial to isolate MelSCs in order to further study their function in pigmentary disorders; however, due to the lack of specific molecular surface markers, this has not yet been successfully accomplished in human hair follicles (HuHF). Read More

J Am Acad Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Department of dermatology, LTMMC & GH, Mumbai.

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):202-210

The Venkat Center-For Skin and Plastic Surgery, Bengaluru, Karnataka, India.

Recipient area is the canvas in a hair transplant surgery, where the surgeon can truly display his artistic creativity and deliver an aesthetic masterpiece, after all hair transplantation is as much about art as science. There are four main steps in dealing with the recipient area. Marking the hairline and estimation of grafts is the most important steps to give a natural look. Read More

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):195-201

Rejuvenate Hair Transplant Centre, Indore, Madhya Pradesh, India.

FUE or follicular unit excision is one of the methods for hair follicle harvesting in hair transplantation. FUE involves harvesting hairs from the donor area, under local anesthesia which is most commonly the scalp but occasionally beard, chest and other parts of the body, using a circular punch less than a mm, mounted on a manual handle or a motorized hand device or more recently a robotic device. First hair transplant was done by Dr Shoji Okuda in 1937. Read More

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):190-194

AK Clinics, Sarabha Nagar, Ludhiana, Punjab, India.

Hair transplant is a constantly evolving science. From the time that it was conceived by Dr. Norman Orentreich to the present state, the procedure of hair transplant has undergone multiple advancements. Read More

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):182-189

Joshi Hospital, Pune, Maharashtra, India.

Hair transplantation is a relatively safe surgery and is associated with very few complications. It is a cosmetic surgery so the complications may impact social and psychological aspect of the patient. Every hair transplantation surgeon should be aware of possible complications and techniques for the prevention and techniques of their management. Read More

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):173-181

Consultant Dermatologist, The Venkat Center for Skin and Plastic Surgery, Bengaluru, Karnataka, India.

Hair transplantation being a relatively new field, several aspects raise issues and controversies. The issues refer to both ethics and evidence and how practitioners and the community need to deal with them. This article deals with few of such diverse issues as follicular unit transplantation versus follicular unit excision, safe donor area, platelet-rich plasma, and minimum qualification for performing hair transplantation. Read More

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):169-172

The Venkat Center for Skin and Plastic Surgery, Bangalore, India.

Hair transplant is a seemingly illogical process wherein we are using a small number of hairs to cover a large area of baldness. This is possible if one understands the logic of this equation. Understanding the pattern of hair distribution, and the sequence of balding, helps us learn the limitations of this technique and give the best possible results to the patient. Read More

Skin Appendage Disord 2019 Feb 5;5(2):65-71. Epub 2018 Sep 5.

Department of Dermatology and Dermatopathology, University of California-Irvine, Irvine, California, USA.

Importance: Hair loss, or alopecia, is one of the most commonly presented problems in dermatology. Scarring alopecias are considered particularly damaging due to limited success in slowing permanent disease progression, and current treatment methods, such as intralesional and topical steroids and topical minoxidil, are largely ineffective.

Objective: Hair transplantation is a debated treatment option for advanced cases of primary scarring alopecia. Read More

Dermatol Reports 2019 Jan 23;11(1):7853. Epub 2019 Jan 23.

Department of Pathology.

Trps1 is considered as an important gene involved in the interactions between the epithelial and mesenchymal cells during hair follicle morphogenesis. The number of hair follicles in Trps1 Knockout (KO) newborn mouse skin was significantly lower than that in wild-type (WT) newborn skin. To gain insight into the functional role of Trps1 in hair development, we transplanted Trps1 KO newborn mouse skin on the backs of nude mice and examined hair growth at day 42 after transplantation. Read More

Int J Womens Dermatol 2019 Feb 23;5(1):37-45. Epub 2019 Jan 23.

Howard University College of Medicine, Washington, District of Columbia.

Hair loss is common in women of color, and is associated with significant psychosocial complaints. Early clinical recognition and prompt initiation of intervention with medical treatment is critical to halt the disease process. In this article, we review the clinical presentations of nonscarring and scarring alopecias in women of color, use of dermoscopy for early recognition of the disease process, and medical, procedural, and surgical interventions. Read More

J Drugs Dermatol 2019 Feb;18(2):155-160

Introduction: Topical minoxidil is the first-line therapy for treating both male and female androgenetic alopecia. Currently there are no comprehensive reviews on the clinical efficacy of minoxidil on hair loss. Method: A literature search was conducted to identify clinically relevant studies regarding the efficacy of topical minoxidil for human subjects for hair loss. Read More

Oral Maxillofac Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopedics and Plastic Surgery, Wright State University, Dayton, OH, USA.

Purpose: Alopecia is a debilitating disorder affecting millions of individuals worldwide. Although challenging to treat, advances in hair restoration technologies have led to multiple viable options with excellent clinical results. This paper seeks to provide an overview of hair loss and the currently utilized techniques in hair transplantation in order to serve as a reference source for the facial plastic surgeon. Read More

Nat Commun 2019 02 8;10(1):650. Epub 2019 Feb 8.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, 92697, USA.

During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study wound fibroblast diversity using single-cell RNA-sequencing. Read More

Transplant Proc 2019 Jan - Feb;51(1):187-189. Epub 2018 Jun 30.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: Alcohol use disorders have a prevalence of 10% among the population of the United States and Europe and are one of the most frequent causes of liver cirrhosis in the Western world. Currently, alcohol-related liver cirrhosis represents one of the most frequent indications to liver transplant (LT), both as independent cause or associated with hepatitis C virus or hepatitis B virus infections. Starting from 2014, a multidisciplinary team involving surgeons, gastroenterologists, clinical toxicologists, psychiatrists, and psychologists was developed within the Modena Liver Transplant Center. Read More

Aging (Albany NY) 2019 Feb;11(3):908-920

Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Adipose-derived stem cells (ASCs) have a demonstrative therapeutic potential in aging-associated facial nerve regeneration, in which ASCs work as a source of Schwann cells therapy as an alternative to autologous nerve grafts. However, the transplantation of ASCs may induce local fibrosis, which causes inferior outcome. Here, we aimed to use genetic modification approaches to reduce the fibrogenic properties of ASCs to improve their therapeutic effects on facial nerve regeneration. Read More

Am J Med Genet A 2019 Mar 31;179(3):442-447. Epub 2019 Jan 31.

Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.

An international advisory group met at the National Institutes of Health in Bethesda, Maryland in 2017, to discuss a new classification system for the ectodermal dysplasias (EDs) that would integrate both clinical and molecular information. We propose the following, a working definition of the EDs building on previous classification systems and incorporating current approaches to diagnosis: EDs are genetic conditions affecting the development and/or homeostasis of two or more ectodermal derivatives, including hair, teeth, nails, and certain glands. Genetic variations in genes known to be associated with EDs that affect only one derivative of the ectoderm (attenuated phenotype) will be grouped as non-syndromic traits of the causative gene (e. Read More

Int J Dermatol 2019 Mar 24;58(3):360-364. Epub 2019 Jan 24.

Dana Plastic Surgery Clinic, Seoul, Korea.

Background: People with high forehead may suffer substantially from feelings of inferiority related to facial appearance. A high forehead can make the face appear longer, larger, and even older.

Materials And Methods: The study included a total of 89 patients with a chief complaint of high forehead who underwent hair transplantation to lower the frontal hairline. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 01;33(1):85-92

Department of Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011,

Objective: To investigate whether desferrioxamine (DFO) can enhance the homing of bone marrow mesenchymal stem cells (BMSCs) and improve neovascularization in random flaps of rats.

Methods: BMSCs and fibroblasts (FB) of luciferase transgenic Lewis rats were isolated and cultured. Forty 4-week-old Lewis male rats were used to form a 10 cm×3 cm rectangular flap on their back. Read More

Anat Rec (Hoboken) 2019 Jan 11. Epub 2019 Jan 11.

Auditory Neurobiology Laboratory, Department of Otorhinolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Stem-cell-based therapy may be used to replace damaged or lost neurons in the cochlear nerve of patients suffering from severe-to-profound sensorineural hearing loss. In order to achieve functional recovery in future clinical trials, knowledge about survival of grafted cells and their differentiation into functional neurons is a prerequisite. This calls for non-invasive in vivo visualization of cells and long-term monitoring of their survival and fate after cochlear transplantation. Read More

Ann Plast Surg 2019 Mar;82(3):320-329

Department of Orthopedics, University of Illinois, Chicago, IL.

Background: We report new data for a rare face transplant performed 3 years ago. Granulomatosis with polyangiitis (GPA) (Wegener) is a severe autoimmune necrotizing vasculitis and parenchymal inflammatory disease that can affect any organ including those of the craniofacial region. Skin involvement manifests as malignant pyoderma. Read More

Int J Legal Med 2019 May 7;133(3):767-770. Epub 2019 Jan 7.

Institute of Forensic Medicine, University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 12, Kiel, Germany.

We report a case of identity testing in which a patient charged us with the verification of a semen sample that he had donated and cryopreserved more than 20 years ago and now was suspecting of having been inadvertently interchanged. We found a non-match of the DNA profiles of the patient's blood and the semen samples but could show that this was due to the patient having received a stem cell transplantation of his full brother as part of a cancer therapy in 1997 which was not known to us when the samples were first tested. Also, the blood and semen samples exhibited a low probability of full sibship at first supporting the patient's suspicion that his semen sample might indeed have been interchanged. Read More

Dermatol Surg 2019 Apr;45(4):557-565

Mediteknia Skin and Hair Laboratory, Las Palmas de Gran Canaria, Spain.

Background: Studies highlighting the role of hair follicles (HFs) in wound healing have raised the challenge of bringing this knowledge to clinical applications. A successful translation is the transplantation of scalp HFs into chronic wounds to promote healing.

Objective: To characterize scar formation and hair growth in nonhealing ulcers after transplantation. Read More

J Clin Immunol 2019 Jan 3;39(1):81-89. Epub 2019 Jan 3.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA.

The association of immunodeficiency-related vaccine-derived rubella virus (iVDRV) with cutaneous and visceral granulomatous disease has been reported in patients with primary immunodeficiency disorders (PIDs). The majority of these PID patients with rubella-positive granulomas had DNA repair disorders. To support this line of inquiry, we provide additional descriptive data on seven previously reported patients with Nijmegen breakage syndrome (NBS) (n = 3) and ataxia telangiectasia (AT) (n = 4) as well as eight previously unreported patients with iVDRV-induced cutaneous granulomas and DNA repair disorders including NBS (n = 1), AT (n = 5), DNA ligase 4 deficiency (n = 1), and Artemis deficiency (n = 1). Read More

Aesthetic Plast Surg 2019 Apr 3;43(2):376-382. Epub 2019 Jan 3.

Department of Plastic and Aesthetic Surgery, Nan Fang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Background: It is necessary to evaluate a successful cosmetic procedure from the patients' perspective. FACE-Q is a patient-reported outcome scale for patients undergoing cosmetic procedures. However, currently there are no FACE-Q scales used in the field of hair transplant surgery. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13522

Department of Plastic Surgery, Affiliated Hangzhou First People's Hospital.

For extensive irregular cicatricial alopecia after burn, effective and pleasing restoration of hair-bearing scalp remains challenging. In this article, the authors presented staged reconstructive treatment for extensive irregular cicatricial alopecia with the goal to achieve better and reliable results. A retrospective review of staged reconstructive treatment performed in 16 patients with extensive irregular cicatricial alopecia after burn was conducted. Read More

Zhonghua Shao Shang Za Zhi 2018 Dec;34(12):840-843

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.

The Department of Burns and Plastic Surgery of the Fouth Medical Center of PLA General Hospital (the former 304th hospital of PLA) was established in 1958 as one of the earliest specialized burn departments in China. In the pioneering efforts of professor Sheng Zhiyong, an internationally renowned authority in burn surgery and an academician of the Chinese Academy of Engineering, several generations of the department represented by Zhu Zhaoming, GuoZhenrong, Chai Jiake, Yang Hongming, and Shen Chuan'an have worked hard from inheritance to innovation. The Department of Burns and Plastic Surgery has evolved from a simple treatment-oriented department to a military priority built discipline, a military burn research institute, a national key clinical specialty and a national key discipline which integrates treatment, scientific research, achievement transformation, and talent training. Read More

J Cosmet Dermatol 2018 Dec 23. Epub 2018 Dec 23.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China.

Background: Frustrated with the embarrassing appearance, patients with androgenetic alopecia (AGA) suffer from poor quality of life and low self-esteem. Moreover, several researches indicate that self-esteem is an important factor affecting outcomes of cosmetic surgery.

Objective: This retrospective study aims to investigate the impact of hair transplantation on patients' self-esteem and satisfaction with appearance, as well as relationship between self-esteem and patient satisfaction which includes preoperative and postoperative satisfaction. Read More

Transpl Immunol 2019 04 21;53:38-42. Epub 2018 Dec 21.

Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Introduction: Chimerism is defined as coexistence of different cell lines in an individual. 46,XX/46,XY chimerism is very rare and exhibits broad range of clinical phenotypes. Most cases are detected at infancy or younger age due to disorders of sex development, while phenotypically normal cases are incidentally discovered through abnormal blood grouping results or multiple genotypes in HLA. Read More

Nat Commun 2018 12 13;9(1):5293. Epub 2018 Dec 13.

Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More

Nat Commun 2018 12 13;9(1):5301. Epub 2018 Dec 13.

Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.

Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed molds. Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs. Read More

Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.

Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

The Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland.

The scalp is a potential location for both benign and malignant tumors. Lymphoproliferative diseases can involve the skin as a primary or secondary manifestation. Dermoscopy is a noninvasive diagnostic tool for rapid diagnosis, screening, and follow-up of the majority of skin tumors. Read More