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    Transplantation of mouse-induced pluripotent stem cells into the cochlea for the treatment of sensorineural hearing loss.
    Acta Otolaryngol 2017 Jun 23:1-7. Epub 2017 Jun 23.
    a Department of Otorhinolaryngology Head and Neck Surgery , the First Affiliated Hospital of Nanchang University , Nanchang , China.
    Conclusion: Mouse-induced pluripotent stem cells (iPSCs) could differentiate into hair cell-like cells and spiral ganglion-like cells after transplantation into mouse cochleae, but it cannot improve the auditory brain response (ABR) thresholds in short term.

    Objective: To evaluate the potential of iPSCs for use as a source of transplants for the treatment of sensorineural hearing loss (SNHL).

    Methods: Establishing SNHL mice model, then injecting the iPSCs or equal volume DMEM basic medium into the cochleae, respectively. Read More

    The roles of the PD-1/PD-L1 pathway at immunologically privileged sites.
    Am J Reprod Immunol 2017 Jun 6. Epub 2017 Jun 6.
    Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    The PD-1/PD-L1 pathway plays a vital role in the maintenance of peripheral tolerance, promoting the development and function of regulatory T cells, and maintaining the quiescence of autoreactive T cells. Abnormalities in this inhibitory pathway are involved in the pathogenesis of some disorders such as tumours, autoimmune diseases, pregnancy complications, and transplantation rejection. Immune privilege represents a special immunological condition, where foreign antigens can be tolerated and do not elicit an immune response. Read More

    Body to Scalp: Evolving Trends in Body Hair Transplantation.
    Indian Dermatol Online J 2017 May-Jun;8(3):167-175
    Cosmazone Hair Restoration Clinics, Mumbai-Gwalior-Delhi, India.
    Follicular unit extraction (FUE) is becoming an increasingly popular method for hair restoration. As FUE leaves behind no linear scars, it is more suitable to harvest from various body areas including beard, chest, and extremities in hirsute individuals. Body hair characteristics such as thickness, length, and hair cycle may not completely match to that of the scalp hair. Read More

    Regenerative medicine in hearing recovery.
    Cytotherapy 2017 May 19. Epub 2017 May 19.
    Bioacoustics Research Laboratory, Department of Neurosciences, University of Padua, Padua, Italy; Foundation Onlus Staminali e Vita, Padua, Italy. Electronic address:
    Hearing loss, or deafness, affects 360 million people worldwide of which about 32 million are children. Deafness is irreversible when it involves sensory hair cell death because the regenerative ability of these cells is lost in mammals after embryo development. The therapeutic strategies for deafness include hearing aids and/or implantable devices. Read More

    Dose-dependent effects of ouabain on spiral ganglion neurons and Schwann cells in mouse cochlea.
    Acta Otolaryngol 2017 May 14:1-7. Epub 2017 May 14.
    a Department of Otolaryngology - Head and Neck Surgery , Renmin Hospital of Wuhan University , Wuhan , China.
    Objective: This study aimed in fully investigating the toxicities of ouabain to mouse cochlea and the related cellular environment, and providing an optimal animal model system for cell transplantation in the treatment of auditory neuropathy (AN) and sensorineural hearing loss (SNHL).

    Methods: Different dosages of ouabain were applied to mouse round window. The auditory brainstem responses and distortion product otoacoustic emissions were used to evaluate the cochlear function. Read More

    Scalp threading with polydioxanone monofilament threads: A novel, effective and safe modality for hair restoration.
    J Eur Acad Dermatol Venereol 2017 May 14. Epub 2017 May 14.
    Department of Dermatology, L.T.M. Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.
    The current medical treatment options for androgenetic alopecia (AGA), although effective, tend to show a plateauing off of the response with no further hair growth.(1) Hair transplantation is unacceptable tomany patients owing to it being a surgical modality and/or the cost involved. This article is protected by copyright. Read More

    Evaluation of persistence and distribution of intra-dermally administered PKH26 labelled goat bone marrow derived mesenchymal stem cells in cutaneous wound healing model.
    Cytotechnology 2017 May 11. Epub 2017 May 11.
    Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
    The current study was designed to study the persistence and distribution of caprine bone marrow derived mesenchymal stem cells (cBM-MSCs) when administered intra-dermally in experimentally induced cutaneous wounds in rabbits. MSC's from goat bone marrow were isolated and their differentiation potential towards adipogenic and osteogenic lineages were assayed in vitro. The isolated cells were phenotypically analysed using flow cytometry for the expression of MSC specific matrix receptors (CD73, CD105 and Stro-1) and absence of hematopoietic lineage markers. Read More

    Evolution and Development of the Inner Ear Efferent System: Transforming a Motor Neuron Population to Connect to the Most Unusual Motor Protein via Ancient Nicotinic Receptors.
    Front Cell Neurosci 2017 24;11:114. Epub 2017 Apr 24.
    Department of Biology, University of IowaIowa, IA, USA.
    All craniate chordates have inner ears with hair cells that receive input from the brain by cholinergic centrifugal fibers, the so-called inner ear efferents (IEEs). Comparative data suggest that IEEs derive from facial branchial motor (FBM) neurons that project to the inner ear instead of facial muscles. Developmental data showed that IEEs develop adjacent to FBMs and segregation from IEEs might depend on few transcription factors uniquely associated with IEEs. Read More

    Follicular Unit Extraction for Hair Transplantation: An Update.
    Actas Dermosifiliogr 2017 May 5. Epub 2017 May 5.
    Clinica Mediteknia de Dermatología y Trasplante Capilar , Las Palmas de Gran Canaria, España.
    Follicular unit extraction (FUE) is a hair transplantation technique that uses small punches (0.8-1 mm in diameter) to extract the follicular units (FUs). Though initially the technique was not widely accepted because of the difficulty of extracting intact follicular units with such small punches, it has since gained in popularity due mainly to rising patient demand, the availability of better instrumentation and greater surgical skill acquired from experience. Read More

    Pretrimmed versus Direct Nonshaven Follicular Unit Extraction.
    Plast Reconstr Surg Glob Open 2017 Mar 16;5(3):e1261. Epub 2017 Mar 16.
    Dana Plastic Surgery Clinic, Gangnam-gu, Seoul, Korea.
    Background: Shaving the donor area is one of the major deterrents preventing hair transplant patients from selecting follicular unit extraction (FUE). A minimal shaved donor area is possible in strip surgery, but the strip method is not applicable if the patient wishes to avoid a linear donor scar, wishes to minimize postoperative pain, or has insufficient scalp laxity. In these cases, nonshaven FUE (NS-FUE) is potentially a very good choice. Read More

    Various Types of Minor Trauma to Hair Follicles During Follicular Unit Extraction for Hair Transplantation.
    Plast Reconstr Surg Glob Open 2017 Mar 16;5(3):e1260. Epub 2017 Mar 16.
    Dana Plastic Surgery Clinic, Gangnam-gu, Seoul, Korea.
    Background: When performing follicular unit extraction (FUE), various types of minor hair follicle trauma unapparent during follicular unit strip surgery are likely to occur. However, no studies have examined such damage.

    Methods: In total, 100 grafts were randomly selected from each of 42 patients who underwent FUE with a 1-mm-diameter sharp punch. Read More

    Hair diameter evaluation in different regions of the safe donor area in Asian populations.
    Int J Dermatol 2017 Jul 24;56(7):784-787. Epub 2017 Apr 24.
    Innovative Skin and Laser Surgery Center, Bangkok, Thailand.
    Background: There is little information about how hair diameter differences within the safe donor area. Thicker or thinner hair may be needed depending on the recipient area, hairline design, and surgical purpose.

    Methods: Thirty-eight non-alopecic subjects (19 males and 19 females) were evaluated. Read More

    Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study.
    Am J Pathol 2017 Jun 20;187(6):1380-1398. Epub 2017 Apr 20.
    Regenerative Biology to Reconstructive Therapies (REBIRTH), Laboratory of Regenerative Immune Therapies Applied, Hannover Medical School, Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address:
    Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Read More

    CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homeostasis and induces autoimmune-like alopecia.
    Exp Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Designed Animal and Transplantation Research Institute, Greenbio Research and Technology, Seoul National University, 1447 Pyeongchang-Ro, Daewha, Pyeongchang, Kangwon, 25354, Korea.
    Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6. Read More

    A Unique Clinicopathological Manifestation of Fungal Infection: A Case Series of Deep Dermatophytosis in Immunosuppressed Patients.
    Am J Clin Dermatol 2017 Apr 8. Epub 2017 Apr 8.
    Department of Dermatology, Rabin Medical Center - Beilinson Hospital, 39 Jabotinski St., Petach Tikva, 4941492, Israel.
    Background: Dermatophytes are the most common cause of superficial fungal infections in humans. Deep dermatophytosis, however, is rare, described to date only in isolated case reports, usually in the setting of systemic immunosuppression.

    Objective: To present the 15-year experience of a tertiary dermato-mycology clinic with the diagnosis and treatment of deep dermatophytosis. Read More

    Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium.
    Sci Rep 2017 04 7;7:46058. Epub 2017 Apr 7.
    Kresge Hearing Research Institute, Otolaryngology - Head and Neck Surgery, The University of Michigan Medical School, MSRB-3, Rm. 9301 1150 W. Medical Center Dr. Ann Arbor, MI 48109-5648, USA.
    Hair cells in the mature cochlea cannot spontaneously regenerate. One potential approach for restoring hair cells is stem cell therapy. However, when cells are transplanted into scala media (SM) of the cochlea, they promptly die due to the high potassium concentration. Read More

    Retrospective Assessment of Follicular Unit Density in Asian Men With Androgenetic Alopecia.
    Dermatol Surg 2017 May;43(5):672-683
    *Department of Dermatology, St. Luke's Medical Center, Manila, Philippines; †International Society of Hair Restoration Surgery, DHT Clinic, Bangkok, Thailand; ‡American College of Surgeons, Chicago, Illinois, §International Society of Hair Restoration Surgery, Geneva, Illinois; ¶Hair Restoration Surgery, DHT Clinic, Bangkok, Thailand.
    Background: Hair density, together with hair diameter has a tremendous impact on the cosmetic outcome of hair transplantation surgery.

    Objective: This retrospective study aims to assess the average number of follicular unit (FU) grafts in the donor area of Asian men with androgenetic alopecia.

    Methods: Seventy patients (ages 24-65 years old) with virgin scalp who had their first hair transplantation were included. Read More

    Functional Salivary Gland Regeneration.
    Methods Mol Biol 2017 ;1597:135-151
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuou-ku, Kobe, Hyogo, 650-0047, Japan.
    The salivary gland plays important roles in maintaining the health and homeostasis of the oral cavity by regulating functions, such as chewing, digestion, cleaning, and swallowing. Salivary gland dysfunction causes dry mouth syndrome, which includes many oral problems, such as dental caries, bacterial infection, mastication dysfunction, and swallowing dysfunction. Therefore, salivary gland regeneration is expected, and we attempted to establish a method by manual approaches. Read More

    Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells.
    Methods Mol Biol 2017 ;1597:117-134
    Laboratory for Organ Regeneration, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuou-ku, Kobe, Hyogo, 650-0047, Japan.
    Hair follicles develop from the ectoderm in embryos and cyclically regenerate using proper spatiotemporal signaling molecules, which are conserved in organogenesis during adulthood. Previously, we demonstrated that bioengineered hair follicle germs could regenerate functional hair follicles via a three-dimensional cell manipulation technique, which we named the "organ germ method ." We could also regulate the type of hair follicle and pigmentation with correct structures by rearranging the source of the cells. Read More

    Human lung fibroblast-derived matrix facilitates vascular morphogenesis in 3D environment and enhances skin wound healing.
    Acta Biomater 2017 May 27;54:333-344. Epub 2017 Mar 27.
    Center for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Dept. of Biomedical Engineering, Korea University of Science and Technology (UST), Daejeon 34113, Republic of Korea. Electronic address:
    Extracellular matrix (ECM) is crucial to many aspects of vascular morphogenesis and maintenance of vasculature function. Currently the recapitulation of angiogenic ECM microenvironment is still challenging, due mainly to its diverse components and complex organization. Here we investigate the angiogenic potential of human lung fibroblast-derived matrix (hFDM) in creating a three-dimensional (3D) vascular construct. Read More

    Cutaneous applied nano-ZnO reduce the ability of hair follicle stem cells to differentiate.
    Nanotoxicology 2017 May 6;11(4):465-474. Epub 2017 Apr 6.
    a Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University , Qingdao , Shandong , China.
    The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0. Read More

    Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient.
    Transpl Infect Dis 2017 Mar 22. Epub 2017 Mar 22.
    Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada.
    Trichodysplasia spinulosa (TS) is a rare dermatologic complication associated with the immunosuppressive therapy used in solid organ transplantation. The distinctive clinical manifestation of this condition is spiny follicular papules on the face, ears, extremities, and trunk. Histopathologically, abnormally maturing hair follicles with hyperkeratotic material are noted. Read More

    Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood.
    Bone Marrow Transplant 2017 Mar 20. Epub 2017 Mar 20.
    Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.
    Permanent alopecia after haematopoietic stem cell transplantation (HSCT) is distressing and few studies have investigated this late effect. The aim of the study was to assess the percentage of patients with alopecia and investigate risk factors for alopecia. Patients who underwent allogeneic HSCT before age 19 years, from January 1990 to January 2013, who were at least 2 years after transplant and in follow-up in our clinic were included. Read More

    Punch graft versus follicular hair transplantation in the treatment of stable vitiligo.
    J Cosmet Laser Ther 2017 Mar 8:1-4. Epub 2017 Mar 8.
    c Dermatology and Andrology Clinic, Government of Health , Assiut , Egypt.
    Objective: To compare the efficacy of follicular hair transplantation and mini punch graft in the treatment of stable vitiligo.

    Methods: Thirty-two patients with stable vitiligo were included in this comparative study. A single patch from each patient was divided into two halves: one half was treated by punch graft, while the other half was treated by follicular hair transplantation followed by excimer light twice weekly, and the outcome was assessed at 0, 1, 3 and 6 months post operatively by photography and quartile scale. Read More

    VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis.
    J Cell Mol Med 2017 Feb 28. Epub 2017 Feb 28.
    Research Institute of Orthopedics, The Second Affiliated Hospital, School of Medical, Zhejiang University, Hangzhou, China.
    Within the vascular endothelial growth factor (VEGF) family of five subtypes, VEGF165 secreted by endothelial cells has been identified to be the most active and widely distributed factor that plays a vital role in courses of angiogenesis, vascularization and mesenchymal cell differentiation. Hair follicle stem cells (HFSCs) can be harvested from the bulge region of the outer root sheath of the hair follicle and are adult stem cells that have multi-directional differentiation potential. Although the research on differentiation of stem cells (such as fat stem cells and bone marrow mesenchymal stem cells) to the endothelial cells has been extensive, but the various mechanisms and functional forms are unclear. Read More

    Facial Feminization Surgery: Simultaneous Hair Transplant during Forehead Reconstruction.
    Plast Reconstr Surg 2017 Mar;139(3):573-584
    Marbella, Málaga, Spain From the FACIALTEAM Surgical Group, MHC International Hospital.
    Background: Reconstruction of the frontonaso-orbital complex is one of the best-described and most commonly used procedures in the field of facial feminization surgery. To a large extent, this complex determines the facial expression and plays a key role in the visual identification of facial gender. After the forehead, the hairline pattern is the second most important feature of gender identification within the upper third of the face. Read More

    Application of stem cell for the regeneration of spiral ganglion neurons.
    Cell Mol Biol (Noisy-le-grand) 2017 Jan 30;63(1):6-12. Epub 2017 Jan 30.
    Department of Medical Biotechnology, School of advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Over 278 million of people worldwide suffers from hearing loss, and this disease has significant detrimental effects emotionally and economically on individuals and the society in totality. Treatment using cochlear implant dramatically improve the perception, and production of speech, as well as the patient quality of life, with the different sensorineural hearing loss (SNHL). Yet, there are some challenges faced by a cochlear implant. Read More

    The role of macrophages in skin homeostasis.
    Pflugers Arch 2017 Apr 23;469(3-4):455-463. Epub 2017 Feb 23.
    Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8059, USA.
    The skin and its appendages comprise the largest and fastest growing organ in the body. It performs multiple tasks and maintains homeostatic control, including the regulation of body temperature and protection from desiccation and from pathogen invasion. The skin can perform its functions with the assistance of different immune cell populations. Read More

    Innovative modified hair follicle harvesting technique with reverse rake scalp elevator for lower occipital donor area in follicular unit extraction hair transplantation.
    Indian J Plast Surg 2016 Sep-Dec;49(3):390-396
    Department of Plastic Surgery, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India.
    Follicular unit extraction (FUE) is one of the widely practiced minimally invasive follicular harvesting techniques employed during hair transplantation. FUE technique has an advantage of utilising lower occipital area and supra-auricular region as a safe donor area described by Unger, in addition to the standard occipital donor area used in strip method (follicular unit transplant). Despite its potential advantages such as rapid recovery, minimal scarring and reduced post-operative pain; its widespread acceptance is limited due to various factors in variable contribution like steeper learning curve and potentially higher follicular transection rates (FTRs). Read More

    Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors.
    Stem Cells Transl Med 2017 Feb 9;6(2):434-443. Epub 2016 Sep 9.
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.
    Endogenous dermal stem cells (DSCs) reside in the adult hair follicle mesenchyme and can be isolated and grown in vitro as self-renewing colonies called skin-derived precursors (SKPs). Following transplantation into skin, SKPs can generate new dermis and reconstitute the dermal papilla and connective tissue sheath, suggesting they could have important therapeutic value for the treatment of skin disease (alopecia) or injury. Controlled cell culture processes must be developed to efficiently and safely generate sufficient stem cell numbers for clinical use. Read More

    Effect of Procedural-Related Variables on Melanocyte-Keratinocyte Suspension Transplantation in Nonsegmental Stable Vitiligo: A Clinical and Immunocytochemical Study.
    Dermatol Surg 2017 Feb;43(2):226-235
    Departments of *Dermatology, †Histology, and ‡Clinical Pathology, Kasr El-Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Cario, Egypt.
    Background: Melanocyte-keratinocyte suspension (M-K susp) is gaining popularity for vitiligo treatment. Few studies have addressed procedure-related variables.

    Objective: To assess the effect of different M-K susp procedure-related variables on the clinical outcome in stable vitiligo. Read More

    Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.
    Am J Hum Genet 2017 Feb;100(2):364-370
    St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, UK; Centre for Dermatology and Genetic Medicine, Division of Molecular Medicine, University of Dundee, Dundee DD1 5EH, UK. Electronic address:
    SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, genome-wide linkage in an Arab-Israeli pedigree mapped the gene to an approximately 25 cM locus on chromosome 1q24-q32. By using whole-exome sequencing in a further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members. Read More

    A case report of coup de sabre patient with hair transplantation.
    J Dermatolog Treat 2017 Jan 31:1-6. Epub 2017 Jan 31.
    b Tongde Hospital of Zhejiang Province , Hangzhou , China.
    Background: Treatment of coup de sabre must remain conservative until the disease is no longer in an active state. When activity has ceased, some operative intervention is safe and effective for the correction of deformity. While hair transplantation showed high survival rates for the correction of cicatricial alopecia, it has rarely reported to be performed for the correction of coup de sabre. Read More

    Evaluation of Quality of Life and Care Needs of Turkish Patients Undergoing Hematopoietic Stem Cell Transplantation.
    Nurs Res Pract 2016 26;2016:9604524. Epub 2016 Dec 26.
    Istanbul Bilim University Florence Nightingale Hospital School of Nursing, Yazarlar Sokak No. 17, Esentepe, Şişli, 34394 Istanbul, Turkey.
    This descriptive study explored the quality of life and care needs of Turkish patients who underwent hematopoietic stem cell transplantation. The study sample consisted of 100 hematopoietic stem cell transplant patients. Their quality of life was assessed using Functional Assessment of Cancer Therapy-Bone Marrow Transplant Scale. Read More

    Efficacy of 50 Hz electromagnetic fields on human epidermal stem cell transplantation seeded in collagen sponge scaffolds for wound healing in a murine model.
    Bioelectromagnetics 2017 Apr 20;38(3):204-212. Epub 2017 Jan 20.
    Department of Rehabilitation Medicine, Institute of Geriatric Medicine, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China.
    To explore the possible efficacy of electromagnetic fields (EMF) for skin tissue engineering, effects of EMF exposure on epidermal stem cells (ESC) seeded in collagen sponge scaffolds for wound healing in a murine model were investigated. The wound models of a full-thickness defect established with 36 7 ∼ 8-week-old nude mice were randomly divided into three groups: a control group, an ESC-only group, and an ESC with EMF exposure group (frequency of 50 Hz, magnetic induction of 5 mT, 60 min per day for 20 days). ESC were separated from human foreskin and cultured in vitro, and then transplanted with collagen sponge scaffolds as a delivery vehicle to wounds of the ESC-only group, and ESC with EMF exposure group was exposed to EMF after ESC transplantation. Read More

    Evaluation of Gene Expression Patterns in Micrografts Demonstrate Induction of Catagen-Like Processes During Storage.
    Dermatol Surg 2017 Feb;43(2):275-280
    *All authors are affiliated with the Department for Hair Research, Moser Medical Group, Clinic Vienna, Austria.
    Background: Alterations of gene expression patterns may contribute to the commonly observed transient reduction of hair shaft elongation in hair restoration surgery.

    Objective: To elucidate the molecular causes, we evaluated changes in gene expression patterns in hair follicle micrografts during storage.

    Materials And Methods: Micrografts with different amounts of adjacent connective tissue (regular, skinny, and chubby) were stored for different periods, and the expression of key genes was determined: dermal papilla (DP): FGF7, alkaline phosphatase (ALP), versican; outer root sheath: Krt15; inner root sheath: Krt 25; cuticula: Krt85; Henle layer: filaggrin; genes related to apoptosis and growth/differentiation: Caspase 3, Ovol1, and Foxo1. Read More

    Megasessions for Robotic Hair Restoration.
    J Drugs Dermatol 2016 Nov;15(11):1407-1412
    A robotic system can select and remove individual hair follicles from the donor area with great precision and without fatigue. This report describes the use of the robotic system in a megasession for hair restoration. Patients were instructed to cut their hair to 1. Read More

    Proliferation-independent regulation of organ size by Fgf/Notch signaling.
    Elife 2017 Jan 13;6. Epub 2017 Jan 13.
    Stowers Institute for Medical Research, Kansas City, United States.
    Organ morphogenesis depends on the precise orchestration of cell migration, cell shape changes and cell adhesion. We demonstrate that Notch signaling is an integral part of the Wnt and Fgf signaling feedback loop coordinating cell migration and the self-organization of rosette-shaped sensory organs in the zebrafish lateral line system. We show that Notch signaling acts downstream of Fgf signaling to not only inhibit hair cell differentiation but also to induce and maintain stable epithelial rosettes. Read More

    Fabrication of an Orbital Prosthesis Combined With Eyebrow Transplantation.
    J Craniofac Surg 2017 Mar;28(2):479-481
    *Department of Prosthodontics, Faculty of Dentistry, Okan University †Private Practice on Plastic Reconstructive and Aesthetic Surgery, Istanbul, Turkey.
    Fabrication of an orbital prosthesis is considered as a challenging procedure as compared to the other facial prosthesis due to the presence of inactive eye movements and the need of artificial hair in order to mimic eyelashes and eyebrows. Generally these structures are sewed or bonded in the silicone. However, deformation or hair loss is observed within time. Read More

    Pre-vascularization Enhances Therapeutic Effects of Human Mesenchymal Stem Cell Sheets in Full Thickness Skin Wound Repair.
    Theranostics 2017 1;7(1):117-131. Epub 2017 Jan 1.
    Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.
    Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process. Read More

    A murine model of orthotopic periorbital subunit transplantation.
    Burns 2017 Mar 28;43(2):429-435. Epub 2016 Oct 28.
    Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address:
    Background: Conventional reconstructive methods fail to achieve satisfactory results in total eyelid defect cases. Vascularized composite tissue allotransplantation might provide both good appearance and function for these patients. We developed an orthotopic periorbital transplantation model in rats to facilitate further experimentation in this field. Read More

    IBD-Like Features in Syndromic Diarrhea/Trichohepatoenteric Syndrome.
    J Pediatr Gastroenterol Nutr 2017 Jan;64(1):37-41
    *Pediatric Gastroenterology, Hepatology, and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina †Nutrition et Gastroentérologie Pédiatriques, Hôpital Armand-Trousseau ‡UMR_S U1166 Nutriomics, UPMC, Sorbonne University, Paris, France §Pediatric Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina ||Département de Génétique Médicale, Hôpital de la Timone Enfant ¶UMR_S 910, Aix-Marseille Université #Service de Pédiatrie Multidisciplinaire, Hôpital de la Timone Enfant, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
    Background: Very early onset inflammatory bowel disease (VEOIBD) (inflammatory bowel disease [IBD] before 6 years of age) may manifest as a monogenic disease affecting the gastrointestinal tract. Syndromic diarrhea/trichohepatoenteric syndrome (SD/THE), a rare disorder caused by alteration of a complex involved in RNA degradation, has been reported to present with some degree of colitis and in some cases an IBD-like presentation.

    Methods: We reviewed clinical and biological data of 4 previously published cases and added detailed data of 2 new cases of SD/THE with an IBD-like presentation. Read More

    Association Between Scalp Laxity, Elasticity, and Glidability and Donor Strip Scar Width in Hair Transplantation and a New Elasticity Measuring Method.
    Dermatol Surg 2017 Apr;43(4):574-581
    Dana Plastic Surgery Clinic, Seoul, Korea.
    Background: Hair transplantation requires precise evaluation of donor site laxity, elasticity, and glidability.

    Objective: The purpose of this study was to examine the relationship between donor strip scar width and preoperative laxity, elasticity, and glidability.

    Materials And Methods: Preoperative measurements of scalp laxity, elasticity, and glidability and of donor site scar width 10 months postoperatively were evaluated in 88 patients who underwent hair transplantation with strip harvesting. Read More

    Literature Review of Cosmetic Procedures in Men: Approaches and Techniques are Gender Specific.
    Am J Clin Dermatol 2017 Feb;18(1):87-96
    Department of Dermatology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Ezralow Tower 5301, Los Angeles, CA, 90033, USA.
    The proportion of men receiving non-surgical cosmetic procedures has risen substantially in recent years. Various physiologic, anatomic, and motivational considerations differentiate the treatments for male and female patients. Nevertheless, research regarding approaches to the male cosmetic patient is scarce. Read More

    Preoperative evaluation and outcome of corneal transplantation for limbal dermoids: a ten-year follow-up study.
    Int J Ophthalmol 2016 18;9(12):1756-1760. Epub 2016 Dec 18.
    Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Jinan 250021, Shandong Province, China.
    Aim: To summarize preoperative evaluation and outcome of corneal transplantation for limbal dermoids for ten years.

    Methods: Eighty-five patients diagnosed with limbal dermoids and treated with corneal transplantation were analyzed retrospectively. All patients were further divided into two groups according to absence or presence of neovascularization surrounding the dermoids in the corneal stroma. Read More

    Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model.
    Microsc Res Tech 2017 Apr 21;80(4):394-405. Epub 2016 Dec 21.
    Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Prenatal interventions may offer an immense opportunity in therapeutic protocols of malformations of cortical development (MCD). Epidermal neural crest stem cells (EPI-NCSCs) of the hair follicle bulge exhibit features of both embryonic and adult stem cells; these cells maintain their neurologic differentiation capability because of their neural crest origin. However, it is unknown if prenatal use of EPI-NCSCs could be beneficial in targeting methylazoxymethanol (MAM)-induced MCD, which further addressed in the present work. Read More

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