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    1 OF 59

    The use of minoxidil in the treatment of male and female androgenetic alopecia: a story of more than 30 years.
    G Ital Dermatol Venereol 2018 Feb;153(1):102-106
    Unit of Dermatology, Department of Medical and Transplantation Physiopathology, Ca' Granda Ospedale Maggiore Policlinico Foundation, University of Milan, Milan, Italy -
    Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. Read More

    Wound regeneration deficit in rats correlates with low morphogenetic potential and distinct transcriptome profile of epidermis.
    J Invest Dermatol 2018 Jan 6. Epub 2018 Jan 6.
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:
    Large excisional wounds in mice prominently regenerate new hair follicles (HFs) and fat, yet humans are deficient for this regenerative behavior. Currently, wound-induced regeneration remains a clinically desirable, but only partially understood phenomenon. We show that large excisional wounds in rats, across seven strains fail to regenerate new HFs. Read More

    Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients.
    J Audiol Otol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
    Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. Read More

    Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids.
    Cell Rep 2018 Jan;22(1):242-254
    Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
    The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in basic research studies or in vitro drug testing. To date, generation of hair follicles in vitro has only been possible using primary cells isolated from embryonic skin, cultured alone or in a co-culture with stem cell-derived cells, combined with in vivo transplantation. Read More

    Scaffold-Assisted Artificial Hair Implantation in a Rat Model.
    JAMA Facial Plast Surg 2017 Dec 28. Epub 2017 Dec 28.
    Department of Head and Neck Surgery, UCLA Medical Center, Los Angeles, California.
    Importance: Current treatments for alopecia with autograft hair transplantation face limitations that may preclude complete hair restoration and leave patients with donor site scars. Scaffold assisted artificial hair implantation as demonstrated in a rat model may provide an adjunct for hair restoration without donor site morbidity.

    Objective: To design and create porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (ePTFE) hair-bearing scaffolds and evaluate their biocompatibility in a rat model. Read More

    Use of low-level laser therapy in treatment of the androgenic alopecia, the first systematic review.
    J Cosmet Laser Ther 2017 Dec 11:1-6. Epub 2017 Dec 11.
    a Union Hospital , Tongji Medical College, Huazhong University of Science and Technology, Dermatology , Wuhan , China.
    Alopecia is a common disease affecting more than half of the world total number of people. Alopecia exists in different types, but one of the most common of these types is the Androgenic Alopecia which has affected approximately 51% of the total number of males ranging between the age bracket of 40 years and 75 years. This type of alopecia is more common in females who are above the age of 65 years and above. Read More

    Spontaneous hair follicle germ (HFG) formation in vitro, enabling the large-scale production of HFGs for regenerative medicine.
    Biomaterials 2018 Feb 6;154:291-300. Epub 2017 Nov 6.
    Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan. Electronic address:
    Hair follicle morphogenesis is triggered by reciprocal interactions between hair follicle germ (HFG) epithelial and mesenchymal layers. Here, we developed a method for large-scale preparation of HFGs in vitro via self-organization of cells. We mixed mouse epidermal and mouse/human mesenchymal cells in suspension and seeded them in microwells of a custom-designed array plate. Read More

    A Novel Multi-Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals.
    J Drugs Dermatol 2017 Nov;16(11):s141-s148

    Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. Read More

    New-Generation Therapies for the Treatment of Hair Loss in Men.
    Dermatol Clin 2018 Jan 12;36(1):63-67. Epub 2017 Oct 12.
    Department of Dermatology, Weill Cornell Medicine, New York, NY, USA; Department of Dermatology, University of Buffalo, Buffalo, NY, USA. Electronic address:
    Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants. Read More

    Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants.
    PLoS One 2017 30;12(10):e0187183. Epub 2017 Oct 30.
    Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, South Holland, the Netherlands.
    Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type of therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory neurons and glial cells, and (3) can easily be harvested in relatively high numbers. However, HFBSCs have never been used for this purpose. Read More

    Optimizing Male Periorbital Rejuvenation.
    Dermatol Surg 2017 Nov;43 Suppl 2:S196-S202
    *Charlotte Plastic Surgery, Charlotte, North Carolina; †Hofstra University Northwell School of Medicine, New York, New York; ‡Dallas Plastic Surgery Institute, Dallas, Texas.
    Background: Facial rejuvenation continues to be an increasing trend among males. The periorbital region deserves special mention given the overall differences in aesthetics between sexes.

    Objective: To examine the aesthetics of the upper eyelid, lower eyelid, lateral canthus, and brow with respect to male periorbital rejuvenation. Read More

    Hair Transplantation Controversies.
    Dermatol Surg 2017 Nov;43 Suppl 2:S158-S162
    *Private Practice, Dermatology, New York, New York; †Weill Cornell Medical Center, New York, New York; ‡Heights Dermatology, Brooklyn, New York; §Tulane Health Sciences Center, New Orleans, Louisiana; ‖Private Practice, Old Metairie Dermatology, Metairie, Louisiana.
    Background: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss.

    Objective: To review some current controversies in hair transplant surgery. Read More

    Hair Transplantation in Migraine Headache Patients.
    Plast Reconstr Surg Glob Open 2017 Sep 21;5(9):e1503. Epub 2017 Sep 21.
    SO-EP Aesthetic & Plastic Surgery Clinic, Kayseri, Turkey.
    Background: Migraine headache is a primary neurologic disease affecting millions of people worldwide. As a consequence, quality of life is diminished, productivity suffers (through loss of work force), and treatment costs are substantial. The occurrence rate in the general population is quite high, with women accounting for 3 of every 4 cases. Read More

    Traction alopecia: A neglected entity in 2017.
    Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):644-649
    Department of Dermatology, School of Medicine, Cardiff University, Cardiff, CF, UK.
    Traction alopecia was first described in 1904 but is still a cause of scarring hair loss in young women worldwide. It is unique in being initially a reversible then an irreversible (scarring) form of alopecia. Linked to tightly-pulled hairstyles, it is seen across all races. Read More

    Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study.
    Am J Transplant 2017 Oct 11. Epub 2017 Oct 11.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Read More

    Management of syndromic diarrhea/tricho-hepato-enteric syndrome: A review of the literature.
    Intractable Rare Dis Res 2017 Aug;6(3):152-157
    Aix Marseille Université, INSERM, Génétique Médicale et Génomique Fonctionnelle (GMGF), UMRS 910, Marseille, France.
    Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare disease linked to the loss of function of either TTC37 or SKIV2L, two components of the SKI complex. It is characterized by a combination of 9 signs (intractable diarrhea, hair abnormalities, facial dysmorphism, immune abnormalities, IUGR/SGA, liver abnormalities, skin abnormalities, congenital heart defect and platelet abnormalities). We present a comprehensive review of the management of SD/THE and tested therapeutic regimens. Read More

    Camouflaging Cleft Lip Scar Using Follicular Unit Extraction Hair Transplantation Combined with Autologous Fat Grafting.
    Plast Reconstr Surg 2018 01;141(1):148-151
    Konya, Turkey From the Department of Plastic Surgery, Selcuk University Medical Faculty.
    Background: The scar that occurs after cleft lip surgery poses a serious cosmetic problem. One of the methods used to solve this problem in adult male patients is hair transplantation. However, satisfactory results with this method cannot always be achieved because of possible graft loss. Read More

    FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.
    J Clin Immunol 2017 Nov 21;37(8):751-758. Epub 2017 Sep 21.
    Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Via S. Pansini, 5, 80131, Naples, Italy.
    Since the discovery of FOXN1 deficiency, the human counterpart of the nude mouse, a growing body of evidence investigating the role of FOXN1 in thymus and skin, has been published. FOXN1 has emerged as fundamental for thymus development, function, and homeostasis, representing the master regulator of thymic epithelial and T cell development. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, although the underlying molecular mechanisms still remain to be fully elucidated. Read More

    Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant.
    ACG Case Rep J 2017 13;4:e107. Epub 2017 Sep 13.
    Alpert Medical School, Brown University, Providence, RI.
    Clostridium difficile infections can be life-threatening but are increasingly being treated successfully with fecal microbiota transplantation (FMT). We report two patients with alopecia universalis who developed subsequent hair regrowth after FMT for treatment of recurrent C. difficile infections. Read More

    Extensive Donor Site Keloids in Follicular Unit Extraction Hair Transplantation.
    Int J Trichology 2017 Jul-Sep;9(3):127-129
    Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
    Hair transplantation, a generally regarded as a safe surgical modality for the treatment of androgenetic alopecia, is not without its potential risks and complications. A case of an extensive keloid formation at donor site following follicular unit extraction is discussed. Hair transplant surgeons should be aware of this significant potential complication, especially in patients having previous keloidal tendencies to avoid such disastrous outcomes. Read More

    Accelerated epithelialization and improved wound healing metrics in porcine full-thickness wounds transplanted with full-thickness skin micrografts.
    Wound Repair Regen 2017 Sep 11;25(5):816-827. Epub 2017 Oct 11.
    Dental and Craniofacial Trauma Research Directorate, United States Army Institute of Surgical Research, Fort Sam Houston, Texas.
    Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Read More

    Genetic DNA profile in urine and hair follicles from patients who have undergone allogeneic hematopoietic stem cell transplantation.
    Sci Justice 2017 Sep 13;57(5):336-340. Epub 2017 May 13.
    Unit of Legal Medicine, University of Cantabria, IDIVAL, Cardenal Herrera Oria s/n, 39011 Santander, Spain.
    Biological samples from patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT) constitute a challenge for individual identification. In this study we analyzed the genetic profiles (by the amplification of 15 autosomic STRs) of HSCT patients found in different types of samples (blood, hair and urine) that may be the source of DNA in civil or criminal forensic cases. Our results show that while in hair follicles the donor component was not detected in any patient, thus being a reliable source of biological material for forensic identification, mixed chimerism was detected in urine samples from all patient, and no correlation was found between the time elapsed from the transplant and the percentage of chimerism. Read More

    Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering.
    J Cosmet Dermatol 2017 Sep 8. Epub 2017 Sep 8.
    Private Practice, Dermatology OPD, QU for Health Professional, DermNet NZ's, Tripoli, Tarabulus, Libya.
    The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage. Read More

    The Science and Art of Eyebrow Transplantation by Follicular Unit Extraction.
    J Cutan Aesthet Surg 2017 Apr-Jun;10(2):66-71
    Dermaclinix The Complete Skin and Hair Solution Centre, New Delhi, India.
    Eyebrows constitute a very important and prominent feature of the face. With growing information, eyebrow transplant has become a popular procedure. However, though it is a small area it requires a lot of precision and knowledge regarding anatomy, designing of brows, extraction and implantation technique. Read More

    Adipose-derived stromal cells enhance auditory neuron survival in an animal model of sensory hearing loss.
    Cytotherapy 2017 10 14;19(10):1197-1207. Epub 2017 Aug 14.
    Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Carl von Ossietzky-University, Oldenburg, Germany. Electronic address:
    Background: A cochlear implant (CI) is an electronic prosthesis that can partially restore speech perception capabilities. Optimum information transfer from the cochlea to the central auditory system requires a proper functioning auditory nerve (AN) that is electrically stimulated by the device. In deafness, the lack of neurotrophic support, normally provided by the sensory cells of the inner ear, however, leads to gradual degeneration of auditory neurons with undesirable consequences for CI performance. Read More

    Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.
    Proc Natl Acad Sci U S A 2017 Aug 10;114(34):E7101-E7110. Epub 2017 Aug 10.
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;
    Organoids made from dissociated progenitor cells undergo tissue-like organization. This in vitro self-organization process is not identical to embryonic organ formation, but it achieves a similar phenotype in vivo. This implies genetic codes do not specify morphology directly; instead, complex tissue architectures may be achieved through several intermediate layers of cross talk between genetic information and biophysical processes. Read More

    Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice.
    J Cell Physiol 2018 Mar 4;233(3):2590-2601. Epub 2017 Sep 4.
    Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
    Alopecia areata (AA) is a common autoimmune disorder affecting millions of people worldwide, which manifests as a sudden, non-scarring hair loss. The expression of a pro-inflammatory cytokine, interferon-gamma (INF-γ), has been well established to be involved in the development of AA. As IFN-γ and other cytokines are also known to up-regulate programmed cell death ligand 1 and 2 (PD-L1 and PD-L2), which both negatively control immune responses, we asked whether or not a high number of infiltrated T cells, seen in AA lesions, can modulate the expression of PD-L1 and PD-L2 in skin cells. Read More

    Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness.
    Stem Cells Cloning 2017 6;10:1-10. Epub 2017 Jul 6.
    Kerastem Technologies, San Diego, CA, USA.
    Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10-15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Read More

    Hair transplantation for the treatment of lichen planopilaris and frontal fibrosing alopecia: A report of two cases.
    Australas J Dermatol 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.
    The efficacy of current medical treatments for lichen planopilaris (LPP) and its variant, frontal fibrosing alopecia (FFA), both lymphocyte-mediated primary cicatricial alopecias, is limited. Hair regrowth from scar tissue is usually not possible. Although hair transplantation restores the hairline and increases hair density in patients with cicatricial alopecia, the timing of the transplantation is crucial. Read More

    Hair Diameter Variation in Different Vertical Regions of the Occipital Safe Donor Area.
    Arch Plast Surg 2017 Jul 15;44(4):332-336. Epub 2017 Jul 15.
    Department of Plastic and Reconstructive Surgery, Wonkwang University School of Medicine, Iksan, Korea.
    Background: Little is known concerning hair diameter variation within the safe donor area for hair transplantation surgery. Thicker or thinner hair may be needed, depending on the recipient area, hairline design, and the purpose of surgery.

    Methods: Twenty-seven patients (7 men and 20 women; mean age, 28 years; range, 20-47 years) were included in this study. Read More

    β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model.
    Fitoterapia 2017 Sep 16;121:136-140. Epub 2017 Jul 16.
    Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China. Electronic address:
    Oleanolic acid (OA), a pentacyclic triterpenoid compound which can be found in >1600 plants, has been shown to promote hair growth. To study the mechanisms of OA on hair growth, we investigated hair follicle (HF) growth on four different concentration OA using human hair follicle organ culture model. We found that HFs treated with 1 or 10μg/mL OA showed statistically enhanced elongation of the hair shaft and anagen-like stage. Read More

    Patient Perspectives on Gene Transfer Therapy for Sickle Cell Disease.
    Adv Ther 2017 Aug 17;34(8):2007-2021. Epub 2017 Jul 17.
    Department of Psychology, University of Cincinnati, Cincinnati, OH, USA.
    Introduction: Sickle cell disease (SCD) is a chronic genetic disease with high morbidity and early mortality; it affects nearly 100,000 individuals in the USA. Bone marrow transplantation, the only curative treatment, is available to less than 20% of patients because of a number of access barriers. Gene transfer therapy (GTT) has been shown to be curative in animal models and is approved for use in humans for early-phase studies at a few centers. Read More

    The evolution of artificial hair implantation.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):169-177
    Chair of Dermatology, University of Rome “G. Marconi”, Rome, Italy.
    From the beginning, artificial hair implantation has aroused a lot of interest, sometimes controversial, in the field of hair restoration. The artificial fiber must be of high quality and biocompatible. Biofibre® is a very fine fiber having diameter of 80 m. Read More

    Eyebrow reconstruction.
    Orbit 2017 Oct 12;36(5):273-284. Epub 2017 Jul 12.
    a South Australian Institute of Ophthalmology , University of Adelaide , Adelaide , Australia.
    This is a systematic review of eyebrow reconstruction options, using the PubMed database, as well as dermatology and plastic surgery texts. Eyebrow reconstruction options in various clinical scenarios (small, large, medial, lateral, and total defects) are presented. The goals of eyebrow reconstruction are to provide structural, functional, and aesthetic restoration. Read More

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning.
    Elife 2017 Jul 11;6. Epub 2017 Jul 11.
    Center for Complex Biological Systems, University of California, Irvine, United States.
    The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Read More

    Transplanted adipose-derived stem cells can be short-lived yet accelerate healing of acid-burn skin wounds: a multimodal imaging study.
    Sci Rep 2017 Jul 5;7(1):4644. Epub 2017 Jul 5.
    Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
    The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured and without treatment options. Here, we have shown that transplantation of adipose-derived stem cells (ASCs) accelerates the process of acid burn wound-healing. Read More

    Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration.
    PLoS One 2017 3;12(7):e0180427. Epub 2017 Jul 3.
    Kresge Hearing Research Institute, Department of Otolaryngology-Head & Neck Surgery, University of Michigan, Ann Arbor, MI, United States of America.
    Impairment of spiral ganglion neurons (SGNs) of the auditory nerve is a major cause for hearing loss occurring independently or in addition to sensory hair cell damage. Unfortunately, mammalian SGNs lack the potential for autonomous regeneration. Stem cell based therapy is a promising approach for auditory nerve regeneration, but proper integration of exogenous cells into the auditory circuit remains a fundamental challenge. Read More

    Invasive dermatophyte infection with trichophyton interdigitale is associated with prurigo induced pseudoperforation and a STAT3 mutation.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    Chelsea and Westminster Hospital, London, UK.
    Invasive dermatophyte infection, with extention beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood but inherited mutations in key signaling pathways of the innate immune system have been identified. Read More

    Transplantation of mouse-induced pluripotent stem cells into the cochlea for the treatment of sensorineural hearing loss.
    Acta Otolaryngol 2017 Nov 23;137(11):1136-1142. Epub 2017 Jun 23.
    a Department of Otorhinolaryngology Head and Neck Surgery , the First Affiliated Hospital of Nanchang University , Nanchang , China.
    Conclusion: Mouse-induced pluripotent stem cells (iPSCs) could differentiate into hair cell-like cells and spiral ganglion-like cells after transplantation into mouse cochleae, but it cannot improve the auditory brain response (ABR) thresholds in short term.

    Objective: To evaluate the potential of iPSCs for use as a source of transplants for the treatment of sensorineural hearing loss (SNHL).

    Methods: Establishing SNHL mice model, then injecting the iPSCs or equal volume DMEM basic medium into the cochleae, respectively. Read More

    Evaluation of amnion in creation of neovagina in women with Mayer-Rokitansky-Kuster-Hauser syndrome.
    Fertil Steril 2017 Aug 16;108(2):341-345. Epub 2017 Jun 16.
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
    Objective: To assess the outcome of amnion vaginoplasty in cases of vaginal agenesis due to Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome managed at the authors' institution.

    Design: Retrospective study.

    Setting: Tertiary care hospital. Read More

    Unlocking the vital role of host cells in hair follicle reconstruction by semi-permeable capsules.
    PLoS One 2017 14;12(6):e0179279. Epub 2017 Jun 14.
    Department of Plastic and Aesthetic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
    Organ regeneration is becoming a promising choice for many patients; however, many details about the mechanisms underlying organ regeneration remain unknown. As regenerative organs, hair follicles offer a good model to study the mechanisms associated with regenerative medicine. The relevant studies have mainly focused on donor cells, and there are no systematic studies involving the effect of host factors on hair follicle reconstruction. Read More

    The roles of the PD-1/PD-L1 pathway at immunologically privileged sites.
    Am J Reprod Immunol 2017 Aug 6;78(2). Epub 2017 Jun 6.
    Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    The PD-1/PD-L1 pathway plays a vital role in the maintenance of peripheral tolerance, promoting the development and function of regulatory T cells, and maintaining the quiescence of autoreactive T cells. Abnormalities in this inhibitory pathway are involved in the pathogenesis of some disorders such as tumours, autoimmune diseases, pregnancy complications, and transplantation rejection. Immune privilege represents a special immunological condition, where foreign antigens can be tolerated and do not elicit an immune response. Read More

    Body to Scalp: Evolving Trends in Body Hair Transplantation.
    Indian Dermatol Online J 2017 May-Jun;8(3):167-175
    Cosmazone Hair Restoration Clinics, Mumbai-Gwalior-Delhi, India.
    Follicular unit extraction (FUE) is becoming an increasingly popular method for hair restoration. As FUE leaves behind no linear scars, it is more suitable to harvest from various body areas including beard, chest, and extremities in hirsute individuals. Body hair characteristics such as thickness, length, and hair cycle may not completely match to that of the scalp hair. Read More

    Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration.
    Dermatol Surg 2017 Jun;43(6):848-855
    *All authors are affiliated with the Department of Plastic and Aesthetic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
    Background: The efficiency of hair follicle (HF) reconstruction is decreased by extensive apoptotic remodeling that occurs soon after grafting.

    Objective: To evaluate a basement membrane matrix (matrix) to improve the efficiency of HF reconstruction and serve as a cell delivery vehicle.

    Materials And Methods: Newborn mouse skin cells were suspended in a matrix and transplanted in a chamber assay. Read More

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