Adipose-derived stromal cells enhance auditory neuron survival in an animal model of sensory hearing loss.
- Philipp Schendzielorz,
- Maike Vollmer,
- Kristen Rak,
- Armin Wiegner,
- Nashwa Nada,
- Katrin Radeloff,
- Rudolf Hagen,
- Andreas Radeloff
Cytotherapy 2017 Aug 14. Epub 2017 Aug 14.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Carl von Ossietzky-University, Oldenburg, Germany. Electronic address:
Background: A cochlear implant (CI) is an electronic prosthesis that can partially restore speech perception capabilities. Optimum information transfer from the cochlea to the central auditory system requires a proper functioning auditory nerve (AN) that is electrically stimulated by the device. In deafness, the lack of neurotrophic support, normally provided by the sensory cells of the inner ear, however, leads to gradual degeneration of auditory neurons with undesirable consequences for CI performance. Read More