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J Cosmet Dermatol 2022 May 12. Epub 2022 May 12.

Department of Dermatology, Faculty of Dermatology, RasoolAkram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Exp Dermatol 2022 May 10. Epub 2022 May 10.

İstanbul University, İstanbul Faculty of Medicine, Department of Histology and Embryology, İstanbul, Turkey.

Vitiligo is a depigmentation disease which affects skin and hair follicles with a prevalence of 0.5-1% worldwide. In this study, we aimed to investigate treatmental potential of dermis-derived cells in monobenzone (MBEH)-induced mouse vitiligo model with light and electron microscopy. Read More

Dermatol Ther 2022 May 10:e15577. Epub 2022 May 10.

Department of Life Sciences, BioFort®, Guaynabo, Puerto Rico.

Lasers Med Sci 2022 May 10. Epub 2022 May 10.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.

Numerous individuals suffer from the lower eye bag. Lower eye bag treatment is a challenge that might require new methods. Depending on the cause, there are different treatment approaches to reduce puffiness under the eyes. Read More

J Cosmet Dermatol 2022 May 2. Epub 2022 May 2.

Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran.

Dermatol Surg 2022 May 1;48(5):584-585. Epub 2022 Mar 1.

Decade Renewal Aesthetic Clinic, Gangnamgu, Seoul, South Korea.

J Cosmet Dermatol 2022 Apr 28. Epub 2022 Apr 28.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background And Aim: Cell-based therapy utilizing mesenchymal stem cells (MSCs) is currently being investigated as a therapeutic agent for chronic wounds. There is no evidence regarding effectiveness of the spray and local transfer of this cellular product in diabetic wound healing. Accordingly, the present study, using clinical, pathological and biometric parameters, investigated the effectiveness of the spray of these cells in the healing of diabetic wounds in rats. Read More

J Am Acad Dermatol 2022 Apr 24. Epub 2022 Apr 24.

Dermatology Department, Trichology Unit, Ramon y Cajal University Hospital, Madrid, Spain; Trichology and Hair Transplantation Unit, Grupo Pedro Jaen Clinic, Madrid, Spain.

Front Genet 2022 8;13:870233. Epub 2022 Apr 8.

Department of Genetics, Center of Genomic Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Bone marrow failure represents an umbrella diagnosis for several life-threatening disorders. In many people, the etiology remains unknown for a long time, leading to an odyssey to diagnosis, with numerous tests performed and sometimes inappropriate treatment. Biallelic pathogenic variants in the gene were recently discovered to cause bone marrow failure syndrome type 3, having phenotypic overlap with Fanconi anemia, dyskeratosis congenita, Shwachman-Diamond syndrome, and Diamond-Blackfan anemia. Read More

J Biosci Bioeng 2022 Apr 14. Epub 2022 Apr 14.

Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan; Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. Electronic address:

Dermal papilla cells (DPCs), which play a central role in the regulation of hair follicle development and hair growth, are among the most promising cell sources for hair regenerative medicine. However, a critical issue in the use of DPCs is the immediate loss of hair inducing functions in typical two-dimensional (2D) culture. We have previously demonstrated that when DPCs are encapsulated in drops of collagen gel (named hair beads, HBs), the density of collagen and cells is concentrated >10-fold during 3 d of culture through the spontaneous constriction of the drops, leading to efficient hair follicle regeneration upon transplantation. Read More

Hautarzt 2022 May 15;73(5):358-368. Epub 2022 Apr 15.

Trichomed® Praxis für Haarmedizin und Haartransplantation, Bayreuther Str. 36, 10789, Berlin, Deutschland.

Background And Objectives: Microsurgical autologous hair transplantation, when performed as follicular unit transplantation, may permanently and naturally improve advanced androgenetic alopecia in men and women and also non-active scarring alopecias.

Materials, Methods And Results: Sufficient donor hair and realistic patient expectations as well as an individual surgical planning of the hair distribution are crucial prerequisites for a sustainable hair restoration. They should be determined and evaluated during a personal pre-examination and consultation with the hair surgeon. Read More

J Cosmet Dermatol 2022 Apr 15. Epub 2022 Apr 15.

Department of Dermatology, Rasool Akram Medical Complex Research Development Center (RCRDC), Iran University of Medical Sciences (IUMS), Thran, Iran.

Background: Acne scar treatment is a problem for both the dermatologist and the dermatologic surgeon. Many therapies have been advanced to improve acne scars over the past years. Nevertheless, they were often related to adverse side effects like hyperpigmentation. Read More

J Cosmet Dermatol 2022 Apr 14. Epub 2022 Apr 14.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Vitiligo is a skin disease that is associated with impaired skin immune systems and pigment degradation in skin melanocyte cells. Despite the significant impact of the disease on the quality of life of patients, treatment of the disease using an effective method such as the transplantation of uncultivated melanocytes was considered by researchers around the world. The goal of this research was to use microneedling to transplant epidermal keratinocyte-melanocyte cells suspension for the treatment of vitiligo patients. Read More

Pediatr Dermatol 2022 Apr 13. Epub 2022 Apr 13.

Division of Dermatology, Phoenix Children's Hospital, Phoenix, Arizona, USA.

Alopecia is a common sequela in children undergoing chemotherapy, radiation, and hematopoietic stem cell transplantation. In most cases, this is a transient state in which full hair regrowth eventually occurs, but permanent or persistent alopecia, defined as the presence of incomplete hair regrowth more than 6 months after cessation of treatment, is possible and can be psychologically distressing. We sought to characterize the risk factors that can lead to permanent alopecia following the aforementioned treatments in pediatric populations, as well as diagnostic and treatment options that may be considered, as part of a scoping review of the literature. Read More

Dermatol Surg 2022 Apr 12. Epub 2022 Apr 12.

Burke Pharmaceutical Research, Hot Springs, Arkansas.

Background: Limited information exists on the long-term risks to individuals undergoing procedures in hair restoration surgery. The short-term risks are well known and similar to other procedures in dermatologic surgery. The long-term risks of hair restoration surgery are seldom discussed between the physician and patient. Read More

J Am Acad Dermatol 2022 Apr 7. Epub 2022 Apr 7.

Department of Plastic and Reconstructive Surgery, Ninth People's Hospital Affiliated to Medical School, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Dermatol Ther 2022 Apr 5:e15490. Epub 2022 Apr 5.

Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Cyclosporine-A (Cyc-A) was initially prescribed as systemic therapy for patients receiving solid organ transplants or in patients with graft versus host disease (GVHD). Topical Cyc-A is an ideal form of cyclosporine in the treatment of mucocutaneous disorders as it causes fewer systemic side effects and has more stable results than steroids; however, poor absorption through the skin makes the development of new formulations necessary to improve skin permeability. The aim of this study was to evaluate the efficacy and safety of topical Cyc-A in different dermatological conditions. Read More

Histochem Cell Biol 2022 Apr 4. Epub 2022 Apr 4.

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Intact and healthy hair follicles are important for hair growth after hair follicle transplantation. However, effective and practical evaluation methods for the quality of hair follicles are currently lacking. In the present study, we developed a novel fast staining method for histological examination of hair follicles. Read More

PLoS One 2022 1;17(4):e0266316. Epub 2022 Apr 1.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, United States of America.

Objectives: Caregivers of allogeneic hematopoietic stem cell transplant (HCT) cancer patients experience high caregiver burden and carry a significant amount of responsibility. Mindfulness has the potential to lessen caregiver burden by aiding in stress management. To date, no studies have examined the efficacy of mindfulness in reducing caregiver burden in this population. Read More

Front Cell Dev Biol 2022 10;10:814949. Epub 2022 Mar 10.

Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Hair follicles harbor a rich autologous stem cell pool and human hair follicle-derived mesenchymal stem cells (hHF-MSCs) have multi-lineage differentiation potential. Many sources of MSCs include hHF-MSCs have been attractive candidates for cell therapy, regenerative medicine and tissue engineering. The present study is to explore the effect of intravenous transplantation of hHF-MSCs on bone mass in osteoporotic mice and its mechanism, and provides prospects for clinical applications for the treatment of osteoporosis with hHF-MSCs. Read More

Zhonghua Shao Shang Za Zhi 2022 Mar;38(3):251-255

Institute of Burns, General Hospital of TISCO (the Sixth Hospital of Shanxi Medical University), Taiyuan 030009, China.

To investigate the clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns. A retrospective observational study was used. From June 2017 to June 2019, 33 patients (24 males and 9 females, aged 8-50 years) who met the inclusion criteria with hypertrophic scars in non-functional sites outside the face after burns were treated in General Hospital of TISCO (the Sixth Hospital of Shanxi Medical University). Read More

JAAD Case Rep 2022 Apr 17;22:64-67. Epub 2022 Feb 17.

Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2022 Mar;39(3):338-342

Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research of Zhejiang Province, Hangzhou, Zhejiang 310052, China.

Objective: To detect loss of heterozygosity (LOH) at human leukocyte antigen (HLA) loci in a Chinese patient with leukemia after haploidentical hematopoietic stem cell transplantation.

Methods: HLA genotyping was carried out on peripheral blood, hair follicle and buccal swab samples derived from the patient after the transplantation as well as peripheral blood samples from his parents by using PCR-sequence specific oligonucleotide probe method and PCR-sequence based typing method. Short tandem repeat (STR) loci were detected by using a 23 site STR assay kit and a self-developed 6 STR loci assay for the HLA regions. Read More

Medeni Med J 2022 Mar;37(1):29-35

Kocaeli University Faculty of Medicine, Department of General Surgery, Kocaeli, Turkey.

Objective: Sacrococcygeal pilonidal disease is a chronic discharging wound that causes pain and loss of quality of life. Phenol application is an outpatient procedure with low complications and low recurrence rates. We evaluated the radiological, histological, and clinical results of phenol application. Read More

Drug Des Devel Ther 2022 10;16:635-645. Epub 2022 Mar 10.

Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Platelet rich plasma (PRP) was described as a small volume of plasma containing higher concentrations of platelets than those found in peripheral blood and initially used as a transfusion product for treatment of thrombocytopenia. To date, it was discovered that there are several growth factors and cytokines that can accelerate wound healing and tissue regeneration, leading to a wider range of applications in the medical field, such as in sport medicine, regenerative medicine, and aesthetic medicine. Several studies have shown that PRP can be used effectively for treatment of hair loss. Read More

Pediatr Dermatol 2022 Mar 16. Epub 2022 Mar 16.

Division of Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

Alopecia totalis (AT) is a cosmetically debilitating chronic disease characterized by non-scarring hair loss of the entire scalp. The clinical course of AT is highly unpredictable, and effective durable treatment options are limited. The resolution of alopecia has been reported post-autologous and allogeneic hematopoietic stem cell transplantation; however, no cases of AT remission following chemotherapy alone have been described. Read More

Acta Biomater 2022 Mar 12. Epub 2022 Mar 12.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

Hair follicle (HF) regeneration remains challenging, principally due to the absence of a platform that can successfully generate the microenvironmental cues of hair neogenesis. Here, we demonstrate a 3D bioprinting technique based on a gelatin/alginate hydrogel (GAH) to construct a multilayer composite scaffold simulating the HF microenvironment in vivo. Fibroblasts (FBs), human umbilical vein endothelial cells (HUVECs), dermal papilla cells (DPCs), and epidermal cells (EPCs) were encapsulated in GAH (prepared from a mixture of gelatin and alginate) and respectively 3D-bioprinted into the different layers of a composite scaffold. Read More

Ann Transl Med 2022 Jan;10(2):66

Department of Plastic and Reconstructive Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Reducing cutaneous scar formation is important for assessing the success of skin wound healing. Although it is generally accepted that adipose-derived mesenchymal stem cells (AMSCs) have substantial therapeutic potential, efforts are continuously made to improve the outcome of AMSC therapy. Post-transcriptional suppression of procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 (PLOD1) in AMSCs has been shown to greatly reduce scar formation during skin wound healing, likely through modulating macrophage polarization. Read More

J Am Acad Dermatol 2022 Mar 1. Epub 2022 Mar 1.

Department of Dermatology, Miller School of Medicine, Miami, Florida.

J Cosmet Dermatol 2022 Feb 28. Epub 2022 Feb 28.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.

Background: The search of beauty and youth has received a lot of attention which is proved by increasing cosmetic techniques. The people prefer non-surgical and invasive method for reduction and wrinkles treatment.

Methods: In this study, we used Endolift laser for forehead wrinkles and frown line treatment to evaluate the clinical safety and effectiveness of this technique for reduction of forehead wrinkles and frown line. Read More