Search Our Scientific Publications & Authors

J Cosmet Dermatol 2021 May 14. Epub 2021 May 14.

Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada.

The technique of follicular unit excision for harvesting grafts for hair transplantation procedures has become very popular. This technique relies on the use of small punches to remove viable grafts. Many different punch shapes have been developed to accommodate the varying nature of skin and hair characteristics, resulting in hair transplant surgeons requiring a variety of punches to suit a wide range of patients, which can be overwhelming to the beginner when trying to decide on the optimal choice of a punch to suit a particular skin characteristic. Read More

Am J Med Genet A 2021 May 14. Epub 2021 May 14.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant condition characterized by carpal-tarsal abnormalities; over half of affected individuals also develop renal disease. MCTO is caused by mutations of MAFB; however, there is no clear phenotype-genotype correlation. We describe the first reported family of variable MCTO phenotype due to mosaicism: the proband had classical skeletal features and renal involvement due to focal segmental glomerulosclerosis (FSGS), and the father had profound renal impairment due to FSGS, necessitating kidney transplantation. Read More

Ann Transl Med 2021 Apr;9(7):606

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Facial gender confirmation surgery (FGCS) is a series of procedures which seek to harmonize a patient's face with his/her self-image and gender identity. Originally described in San Francisco in the 1980s, FGCS has evolved to encompass all elements of the craniofacial skeleton and facial soft tissue. This field in plastic and reconstructive surgery has quickly gained more attention in the past decade due to the pioneering work of groups around the world along with increased social acceptance and medical care of the transgender community. Read More

Plast Reconstr Surg Glob Open 2021 Mar 22;9(3):e3480. Epub 2021 Mar 22.

Department of Plastic Reconstructive and Aesthetic Surgery, Koç University, Istanbul, Turkey.

Trichiasis is an acquired condition in which eyelashes are misdirected toward the ocular surface, resulting in eye irritation and ocular morbidities. Different treatment modalities have been described, including surgical and non-surgical methods. The goal of this article is to present a novel technique for treatment of trichiasis, with a brief review of treatment options. Read More

J Cosmet Dermatol 2021 Apr;20 Suppl 1:18-22

Department of Pathophysiology and Transplantation, Università degli Studi, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: The management of acquired hypertrichosis (HT) is based on the search of the causes and subsequent specific treatment. However, simultaneous hair removal is important. No single method for hair removal is appropriate for all patients and skin areas. Read More

Biomedicines 2021 Apr 16;9(4). Epub 2021 Apr 16.

Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, SI-2000 Maribor, Slovenia.

The hair research field has seen great improvement in recent decades, with in vitro hair follicle (HF) models being extensively developed. However, due to the cellular complexity and number of various molecular interactions that must be coordinated, a fully functional in vitro model of HFs remains elusive. The most common bioengineering approach to grow HFs in vitro is to manipulate their features on cellular and molecular levels, with dermal papilla cells being the main focus. Read More

J Clin Med 2021 Apr 1;10(7). Epub 2021 Apr 1.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, IRCCS Policlinico San Donato, Piazza Edmondo Malan 1, San Donato Milanese, 20097 Milan, Italy.

Background: Hidradenitis suppurativa (HS) is an inflammatory and chronic-recurrent disease of the hair follicle. Its aetiopathogenesis is not completely known. Although bacterial colonization and superinfection are clinically relevant, lymph node involvement has rarely been studied. Read More

J Am Acad Dermatol 2021 Apr 26. Epub 2021 Apr 26.

Clinical Professor of Dermatology Weill Cornell Medical School; Private practice, New York, NY, USA.

The second part of this Hair Transplantation review concentrates on technical aspects of the surgery. First, we review the two main local anesthetics used in hair transplantation, lidocaine and bupivacaine, how to achieve long-lasting local anesthesia, and the techniques used to minimize the pain associated with anesthetic infiltrations. Second, we review the two donor harvesting techniques currently used: strip harvesting FUT and FUE. Read More

Ann Dermatol 2020 Oct 29;32(5):388-394. Epub 2020 Sep 29.

Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Particulate matters (PM) comprise a heterogeneous mixture of particles suspended in air. A recent study found that urban PMs may penetrate into hair follicles via transfollicular and transdermal routes in dorsal skin.

Objective: To investigate the effects of PM on cultured human scalp hair follicles and hair follicular keratinocytes . Read More

J Cutan Aesthet Surg 2020 Oct-Dec;13(4):283-291

Department of Dermatology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Background: Vitiligo surgery has evolved a long way from punch skin grafts to the epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension transplantation (EHFORSCS). In the latest development, the novel technique autologous negative pressure epidermal harvesting system (ANPEHS) seems to be a good addition to the prevailing therapy in vitiligo.

Aims And Objectives: The aim of this work was to study and compare novel ANPEHS and suction blister grafting (SBG) in the treatment of stable vitiligo. Read More

J Am Acad Dermatol 2021 Apr 24. Epub 2021 Apr 24.

Clinical Professor of Dermatology Weill Cornell Medical School; Private practice, New York, NY, USA.

Modern hair restoration surgery is based on a technique known as follicular unit transplantation in which follicular units (FUs) are the exclusive structures used as hair grafts. In Part 1 of this two-part review, we describe how the techniques employed in hair transplantation have evolved into their present forms. Anatomic concepts of specific relevance for dermatologists are discussed, including the distribution and ex-vivo morphology of scalp FUs. Read More

J Cosmet Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Acibadem Mehmet Ali Aydinlar University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey.

Background: Hair shaft diameter is one of the most important factors for the outcome of follicular unit extraction (FUE) surgery. In fact, the hair shaft is elliptical. Therefore, it has a long and short axis. Read More

J Cosmet Dermatol 2021 Apr 27. Epub 2021 Apr 27.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Feeling beautiful and staying young have always been important to the people. Therefore, an extensive body of research has focused on the efforts made to remove the skin problems, especially wrinkles. Fibroblast cells of the skin are the various autologous cells currently used in repairing several wounds, scars, and skin aging. Read More

Am J Transl Res 2021 15;13(3):1389-1399. Epub 2021 Mar 15.

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Harbin Medical University Harbin 150086, P. R. China.

Acute pancreatitis (AP) is commonly accompanied by intense pain and is associated with high mortality rates. However, the effectiveness of existing therapeutic approaches remains unsatisfactory. Stem cell therapy, which can promote the regeneration of damaged tissue and alleviate systemic inflammatory responses, has brought new possibility for patients suffering from AP. Read More

Ann Lymphoma 2021 Mar 30;5. Epub 2021 Mar 30.

Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

In 2016 there were an estimated 7,460 newly diagnosed patients with marginal zone lymphoma (MZL) in the US, which comprised 7% of all mature non-Hodgkin lymphomas (NHL). Based on data from the US SEER-18 program from 2001-2017, the age-standardized incidence rate for MZL was 19.6 per 1,000,000 person-years; 9% of MZL cases were splenic MZL (SMZL), 30% nodal MZL (NMZL), and 61% extranodal MZL (EMZL) of mucusa-associated lymphoid tissue (MALT). Read More

Wiad Lek 2021 ;74(3 cz 1):418-422

HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.

Objective: The aim is to develop a method of the acellular dermal matrix manufacturing from pig's skin dermis while preserving the native structure.

Patients And Methods: Materials and methods: Combination of physical and chemical effects on the dermis underlies in the process of an acellular dermal matrix manufacturing. Dermal collection of 1. Read More

J Cosmet Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Curr Biol 2021 Mar 27. Epub 2021 Mar 27.

Division of Vertebrate Zoology and Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA. Electronic address:

The macroevolutionary transition from terra firma to obligatory inhabitance of the marine hydrosphere has occurred twice in the history of Mammalia: Cetacea and Sirenia. In the case of Cetacea (whales, dolphins, and porpoises), molecular phylogenies provide unambiguous evidence that fully aquatic cetaceans and semiaquatic hippopotamids (hippos) are each other's closest living relatives. Ancestral reconstructions suggest that some adaptations to the aquatic realm evolved in the common ancestor of Cetancodonta (Cetacea + Hippopotamidae). Read More

Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):303-305

Department of Dermatology, IGGMC, Nagpur, Maharashtra, India.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130000, P.R. China.

Hair loss, including alopecia, is a common and distressing problem for men and women, and as a result, there is considerable interest in developing treatments that can prevent or reverse hair loss. Dermal papillae closely interact with epidermal cells and play a key role during hair follicle induction and hair morphogenesis. As dermal papilla cells (DPCs) lose their hair‑inducing ability in monolayer cultures , it is difficult to obtain hair follicle structures following DPC transplantation . Read More

J Am Acad Dermatol 2021 Mar 19. Epub 2021 Mar 19.

Department of Plastic Surgery, Hospital of Skin Diseases and Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, Jiangsu, China.

Pediatr Dermatol 2021 Mar 18. Epub 2021 Mar 18.

Department of Plastic Reconstructive Surgery, Osaka Medical College, Takatsuki City, Japan.

Introduction: Hair loss due to scarring as a consequence of surgical procedures and trauma can impact young patients socially and emotionally. Recently follicular unit extraction (FUE) hair transplantation has been applied to scar treatment.

Patients And Methods: This report included four patients with scarring alopecia. Read More

J Cosmet Dermatol 2021 Mar 18. Epub 2021 Mar 18.

Dermatology and Venereology department, Faculty of Medicine, Suez Canal University, 41511, Ismailia, Egypt.

An 18-gauge disposable needles can be smoothly bent by artery forceps in two alternate 90 angles. By determining the desired depth, we can control depth of penetration, inclination angle of needle entry and prevent accidental deep breakthrough by stopping the needle with the bended shoulder (Fig. 1). Read More

J Cosmet Dermatol 2021 Mar 13. Epub 2021 Mar 13.

Hair Transplantation Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The expanded scalps are usually used to repair the scalp defects. However, hair growth direction and hair density of the expanded scalps may be inconsistent with those of the defective sites, resulting in unsatisfactory results.

Aims: The aim of this study was to assess the effect of local flap modification and follicular unit extraction (FUE) on the repair of poor appearance of temporal and sideburn after unsatisfactory tissue expansion. Read More

Plast Reconstr Surg 2021 04;147(4):839-849

From Pontifical Catholic University of Rio Grande do Sul; Hospital Samaritano; and private practice.

Background: Female pattern hair loss is a common nonscarring alopecia that can present with several patterns of decreased hair density. The condition is very bothersome to affected women, and although there are multiple nonsurgical options, surgical follicular unit transplantation remains one of the most effective options.

Methods: A retrospective chart review was performed of the senior author's (C. Read More

Clin Cosmet Investig Dermatol 2021 4;14:225-229. Epub 2021 Mar 4.

Center of Hair Transplantation, Department of Burn and Plastic Surgery, The Fourth Medical Center of the General Hospital of PLA, Beijing, People's Republic of China.

Objective: This study aims to establish the concept of invalid extraction rates in follicular unit extraction and evaluate its clinical value.

Methods: The present study involved 30 patients with alopecia. Three young surgeons (nominated A, B, and C) each performed follicular unit extraction on a randomly selected portion of the donor site of each patient for ten minutes. Read More

J Biosci Bioeng 2021 Mar 4. Epub 2021 Mar 4.

Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Kanagawa 240-8501, Japan; Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan. Electronic address:

Hair regenerative medicine has emerged as a promising treatment strategy for severe hair loss, such as end-stage androgenetic alopecia. Various approaches to engineering three-dimensional tissue grafts have been explored since they drive the ability to regenerate hair follicles when transplanted. In the present study, we demonstrated the assembly of human adipose-derived stem cells (hASCs) into hair follicle germ (HFG)-like aggregates for de novo hair regeneration. Read More

Cells 2021 Feb 18;10(2). Epub 2021 Feb 18.

Research Laboratory Omics Technology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.

Several methods for the stimulation of skin wound repair have been proposed over the last few decades. The most promising among them are gene and stem cell therapy. Our present experiments combined several approaches via the application of human umbilical cord blood mononuclear cells (hUCB-MC) that were transfected with pBud-165-2 plasmid (gene-cell therapy) and direct gene therapy using pBud-165-2 plasmid to enhance healing of full thickness skin wounds in rats. Read More