83,998 results match your criteria Hair Tourniquet Removal
Neuroimage 2018 Dec 13. Epub 2018 Dec 13.
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
The goal of this study was to develop a molecular biomarker for the detection of protein aggregation involved in Alzheimer's disease (AD) by exploiting the features of the water saturation transfer spectrum (Z-spectrum), the CEST signal of which is sensitive to the molecular configuration of proteins. A radial-sampling steady-state sequence based ultrashort echo time (UTE) readout was implemented to image the Z-spectrum in the mouse brain, especially the contributions from mobile proteins at the frequency offsets for the composite protein amide proton (+3.6 ppm) and aliphatic proton (-3. Read More
Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.
Behavior & Welfare Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus, Utrecht University, Utrecht, The Netherlands.
Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. Read More
Cell Mol Gastroenterol Hepatol 2018 Dec 13. Epub 2018 Dec 13.
SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Institute for Medical Science and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
The rising incidence of paediatric inflammatory bowel disease (IBD), coupled with the efficiency of whole exome sequencing, has led to the identification of Tetratricopeptide Repeat Domain 7A (TTC7A) as a steward of intestinal health. TTC7A-deficiency is an autosomal recessively inherited disease. In five years since the original description more than 50 patients with >20 distinct disease-causing TTC7A mutations have been identified. Read More
Neuroscience 2018 Dec 13. Epub 2018 Dec 13.
Department of Otolaryngology, Harvard Medical School, and Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA.
Aging listeners often experience difficulties in perceiving temporally complex acoustic cues in noisy environments. These difficulties likely have neurophysiological contributors from various levels of auditory processing. Cochlear synapses between inner hair cells and auditory nerve fibers exhibit a progressive decline with age which is not reflected in the threshold audiogram. Read More
Environ Int 2018 Dec 12. Epub 2018 Dec 12.
Unit of Molecular Epidemiology and Genetics in Infections and Cancer, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:
Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health.
Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Read More
J Cutan Pathol 2018 Dec 14. Epub 2018 Dec 14.
Hospital of the University of Pennsvylvania, Philadelphia, PA.
Background: Cutaneous focal mucinosis (CFM), or focal dermal mucinosis, is a benign reactive process categorized as a primary mucinosis. Skin biopsy is essential for diagnosis, as the clinical appearance is often non-specific. Follicular induction is a phenomenon whereby the epidermis is induced by an underlying process to form primitive or mature hair follicles, and is commonly seen overlying dermatofibromas. Read More
Aesthetic Plast Surg 2018 Dec 14. Epub 2018 Dec 14.
Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Introduction: In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines that stimulate healing of skin and soft tissues. Read More
Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.
Environmental Remediation and Geopollution Group, Department of Geology, Faculty of Science, Ekiti State University, Ado Ekiti, Private Mail Bag 5363, Ado Ekiti 360001 Nigeria.
This study evaluated the physicochemical and mineralogical properties, mobile chemical species bioavailability and translocation in and L. plants of a South African coal-fired power utility. Coal-fly-ash (CFA) disposal is associated with various environmental and health risks, including air, soil, surface, and groundwater pollution due to the leaching of toxic heavy metals; these ends up in food webs affecting human health, while repeated inhalation causes bronchitis, silicosis, hair loss, and lung cancer. Read More
PLoS One 2018 14;13(12):e0208932. Epub 2018 Dec 14.
National Center of Occupational Safety and Health, Minsk, Belarus.
Background: Exposure to metals via air sampling in workplace has been extensively studied; however, the magnitude of individual exposure in various occupational groups may vary dramatically. The aim of this cross-sectional study was to ascertain exposure to selected metals from metal fumes in a series of typical workplaces of contemporary tractor production.
Methods: Ninety-eight (median age 41 (interquartile range (IQR) 23) years, all men) workers from Minsk Tractor Plant were categorized into four groups, including assembly shop workers (group 1); thermal shop staff (group 2); steelmakers (group 3) and welders (group 4). Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1120-1124
Auditory neuropathy is a disorder characterized by absent or severely abnormal auditory brainstem response (ABR) with intact outer hair cell function, as evidenced by the presence of evoked otoacoustic emissions and/or cochlear microphonics. Unlike patients with sensory hearing loss who show clinical evidence of impaired outer hair cell function. For ANSD patients, clinical rehabilitation is mainly limited to hearing aid wearing and cochlear implantation. Read More
Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.
Department of Otolaryngology - Head and Neck Surgery, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss and pigmentary abnormalities with variable penetrance. Though heterozygous mutations in MITF are a major cause for Waardenburg syndrome type 2 (WS2), homozygous mutations in this gene and the associated phenotype have been rarely characterized. In this study, we identified a novel p. Read More
Int J Cosmet Sci 2018 Dec 14. Epub 2018 Dec 14.
Development Research, Kao Corporation, 2-1-3, Bunka, Sumida-ku, Tokyo, 131-8501, Japan.
Objective: We previously reported that a chemically resistant structure is present at the interface between the cuticle and the cortex of human hair. The goal of this study was to identify the position of that structure and to clarify its barrier ability.
Methods: Untreated, partially and completely decuticled hair fibers were characterized. Read More
J Sci Food Agric 2018 Dec 12. Epub 2018 Dec 12.
Department of Food Science and Engineering, Yanbian University, Yanbian, China.
Background: This study was to investigate the significant effects of extrusion process variables on chemical properties of extruded white ginseng root hair. The extrusion conditions were set as follows: barrel temperature (110 and 140°C), moisture content (20 and 30%), and screw speed (200 and 300 rpm). The powder of white ginseng root hair was extruded as L (2 ) orthogonal experimental design. Read More
Vet Med Sci 2018 Dec 12. Epub 2018 Dec 12.
Synergy Animal General Hospital, Kawaguchi, Saitama, Japan.
A 5-year-old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC-II, and TCRγδ. Read More
Contact Dermatitis 2018 Dec 12. Epub 2018 Dec 12.
Immunology and Allergology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Espinho, Portugal.
Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More
J Clin Imaging Sci 2018 15;8:44. Epub 2018 Nov 15.
Department of Radiology, University of Kentucky, Kentucky, USA.
Waardenburg syndrome (WS) is a rare genetic disorder secondary to neural crest cell developmental abnormalities. It is predominantly described as an auditory-pigmentary syndrome with diverse patient presentation, typically involving congenital sensorineural hearing loss and pigmentation abnormalities of the skin, hair, and iris. Other developmental abnormalities that may be associated with this syndrome are Hirschsprung's disease and a myriad of cardiovascular congenital defects. Read More
Inflamm Regen 2018 7;38:31. Epub 2018 Dec 7.
1Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.
The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipid mediators and essential components of the skin barrier. Phospholipase A (PLA) enzymes supply fatty acids and lysophospholipids from membrane phospholipids, thereby variably affecting cutaneous homeostasis. Read More
Nat Commun 2018 Dec 13;9(1):5293. Epub 2018 Dec 13.
Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.
We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More
Sci Rep 2018 Dec 13;8(1):17813. Epub 2018 Dec 13.
Institute of Technological Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
Electric corona discharge in a multi-phase system results in complex electro-hydrodynamic phenomena. We observed unconventional shock wave propagation on an oil thin film sprayed over a polymer-coated conductor. A hair-thin single shock wave arose when the high voltage bias of an overhung steel needle was abruptly removed. Read More
Nat Commun 2018 Dec 13;9(1):5301. Epub 2018 Dec 13.
Department of Dermatology, Columbia University Medical Center, New York, NY, 10032, USA.
Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such as hair follicles (HFs), into HSCs remains a major challenge. Here, we demonstrate a biomimetic approach for generation of human HFs within HSCs by recapitulating the physiological 3D organization of cells in the HF microenvironment using 3D-printed molds. Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs. Read More
Plant Physiol 2018 Dec 13. Epub 2018 Dec 13.
Kyung Hee University CITY: Yongin STATE: Gyeonggi-do POSTAL_CODE: 17104 Korea (South), Republic Of
Root hairs are important for absorption of nutrients and water from the rhizosphere. The ROOT HAIR DEFECTIVE-SIX LIKE (RSL) Class Ⅱ family of transcription factors is expressed preferentially in root hairs and has a conserved role in root hair development in land plants. We functionally characterized the seven members of the RSL Class II subfamily in the rice (Oryza sativa) genome. Read More
Taiwan J Obstet Gynecol 2018 Dec;57(6):878-880
Center for Gene-Protein Research, Hanoi Medical University, Hanoi, Vietnam. Electronic address:
Objective: Duchenne muscular dystrophy (DMD) is a severe disorder caused by mutation in the X-linked dystrophin gene, therefor carrier testing is required for all female family members. However, there are cases mutation analysis cannot detect any mutation due to a phenomenon called mosaicism. The case report describes a case of mosaicism in a DMD carrier and discusses the approach in diagnosis and counseling of familial disorder. Read More
Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.
Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Ruprecht-Karls-University Heidelberg, 69115 Heidelberg, Germany.
(1) Medical doctors and medical students show increased psychological stress levels. International medical students seem to be particularly vulnerable. (2) We compared different methods of assessing stress levels in international and local first year medical students. Read More
Skin Pharmacol Physiol 2018 Dec 13;32(2):59-64. Epub 2018 Dec 13.
Private practice, Kutahya, Turkey.
Background: Alopecia areata (AA) is a disease characterized by the hair loss sharply limited in any part of the body, especially on the scalp, in circular or oval areas. The purpose of this study is to search the serum paraoxonase 1 (PON1), arylesterase and oxidative status with serum prolidase activities in people with AA.
Methods: The study included 60 AA and 50 healthy control subjects. Read More
Nat Commun 2018 Dec 12;9(1):5075. Epub 2018 Dec 12.
Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, SE1 9RT, UK.
Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease. Read More
BMC Med Genet 2018 Dec 12;19(1):211. Epub 2018 Dec 12.
Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, 55# Zhenhai Road, Xiamen, 361003, China.
Background: Tricho-rhino-phalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by distinctive craniofacial and skeletal abnormalities, while non-ossifying fibroma (NOF) is a common benign bone tumour in children and adolescents. To date, no case of TRPS coexisting with NOF has been reported. This report presents a 12-year-old girl who had the characteristic features of tricho-rhino-phalangeal syndrome and non-ossifying fibroma with a fibula fracture. Read More
J Agric Food Chem 2018 Dec 12. Epub 2018 Dec 12.
Natural melanin features many interesting properties, including the ability to shield electromagnetic radiation, to act as scavenger for radical and reactive oxygen species and the capacity to chelate different metal ions. For these reasons, melanin is becoming increasingly relevant for the development of functional materials, for potential applications such as cosmetics, drug delivery and water purification. However, the extraction and purification of melanin from conventional sources (e. Read More
Arch Public Health 2018 3;76:73. Epub 2018 Dec 3.
1School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, 200 University Ave W, Waterloo, ON Canada.
Background: Human biomonitoring represents an important tool for health risk assessment, supporting the characterization of contaminant exposure and nutrient status. In communities where country foods (locally harvested foods: land animals, fish, birds, plants) are integrated in the daily diet, as is the case in remote northern regions where food security is a challenge, such foods can potentially be a significant route of contaminant exposure. To assess this issue, a biomonitoring project was implemented among Dene/Métis communities of the Dehcho region of the Northwest Territories, Canada. Read More
Front Cell Neurosci 2018 14;12:407. Epub 2018 Nov 14.
Institut des Neurosciences de Montpellier (INM), Inserm, University of Montpellier, Montpellier, France.
During development, the sensory cells of the cochlea, the inner hair cells (IHCs), fire spontaneous calcium action potentials. This activity at the pre-hearing stage allows the IHCs to autonomously excite the auditory nerve fibers and hence, represents an efficient mechanism to shape the tonotopic organization along the ascending auditory pathway. Using calcium imaging, we show that the activity in the developing cochlea consists of calcium waves that propagate across the supporting and sensory cells. Read More
Ergonomics 2018 Dec 7:1-54. Epub 2018 Dec 7.
d School of Psychology , University of Central Lancashire , Preston PR1 2HE.
Witnesses may construct a composite face of a perpetrator using a computerised interface. Police practitioners guide witnesses through this unusual process, the goal being to produce an identifiable image. However, any changes a perpetrator makes to their external facial-features may interfere with this process. Read More
Exp Mol Med 2018 Dec 6;50(12):160. Epub 2018 Dec 6.
Department of Functional Genomics, Korea University of Science & Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon, 34113, Republic of Korea.
Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. Read More
Reumatol Clin 2018 Dec 3. Epub 2018 Dec 3.
Servicio de Inmunología, Hospital Clinic, Barcelona, España.
Trichorhinophalangeal syndrome I (TPRSI) has an autosomal dominant inheritance; the proportion of «de novo» cases is unknown. It is characterized by unique facial features, bulbous nose, flat and elongated nasolabial furrow, thin hair and slow growth. Skeletal abnormalities that include short phalanges and metacarpals -brachydactyly-, cone-shaped epiphyses, hip dysplasia and short stature. Read More
J Acoust Soc Am 2018 Nov;144(5):2967
Department of Neuroscience, Erasmus MC, NL-3000 CA Rotterdam, The Netherlands.
Neurons in the medial superior olive perform a coincidence analysis between inputs from the two ears, as predicted by Jeffress [J. Comp. Psychol. Read More
Horm Res Paediatr 2018 Dec 12:1-9. Epub 2018 Dec 12.
Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Background: Hair glucocorticoids (GCs) offer a retrospective view on chronic GC exposure. We assessed whether maternal pre- and postnatal stress was associated with neonatal and maternal hair GCs postpartum (pp).
Methods: On the first day pp 172 mother-infant pairs donated hair, of whom 67 had consulted a centre of expertise for psychiatric disorders during pregnancy. Read More
PLoS One 2018 12;13(12):e0207871. Epub 2018 Dec 12.
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
Background: Exposure to horses can cause severe allergic reactions in sensitized individuals. The breed, American Bashkir Curly Horse is categorized as hypoallergenic, primarily due to reports of allergic patients experiencing fewer symptoms while handling this special breed. The possible reasons for this phenomenon could be lower allergen production and/or reduced allergen release into the air because of increased sebum content in their skin and hair compared to other breeds. Read More
PLoS One 2018 12;13(12):e0207140. Epub 2018 Dec 12.
R&D Alternative Discovery and Development, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestinal crypt cell regeneration. Motivated by the observations that the upregulation of Atoh1 gene expression, through genetic manipulation or pharmacological inhibition of Notch signaling (e.g. Read More
J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.
Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.
Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More
Methods Mol Biol 2019 ;1897:1-6
Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Biobanks are storage places for biospecimens that can be used for current and future scientific research. Biospecimens are exceptional sources of biological data that can be potentially translated from molecular and genetic information to clinically relevant treatment modalities. Examples of such biospecimens include, but are not limited to, blood, skin, hair, saliva, stem cells, DNA, and RNA. Read More
Biomed Res Int 2018 13;2018:1286480. Epub 2018 Nov 13.
Chinovo Laboratory, Beijing, China.
A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt. Read More
Appl Clin Genet 2018 22;11:151-155. Epub 2018 Nov 22.
Health Sciences Faculty, Universidad Icesi, Cali, Colombia,
Background: Menkes disease is a congenital neurodegenerative disorder caused by gene mutations. Clinical features include epilepsy, growth delay, reduced muscle strength, skin laxity, abnormal hair, and urologic abnormalities.
Case Presentation: We describe an infant with developmental delay, neurologic degeneration, and kinky hair. Read More
J Parasit Dis 2018 Dec 15;42(4):550-553. Epub 2018 Oct 15.
2Department of Veterinary Clinical Complex, College of Veterinary Science, Faculty of Veterinary Medicine, Sri Venkateswara Veterinary University, Proddatur, Andhra Pradesh 516 360 India.
Present study was aimed to record the spp. eggs in dog's hair and to analyze the incidence in breed and age wise along with incidence variations in the anatomical locations of hair over the body. Dogs presented to the hospital were screened for enteric parasitic ova and hair samples were collected from the different body regions including head and neck region, ventral and lateral abdomen, perianal and hindquarters and tail region. Read More
Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.
Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More
Horm Res Paediatr 2018 12 11:1-10. Epub 2018 Dec 11.
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.
Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.
Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More
Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.
Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.
Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More
Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.
The Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, U.K.
Topical dithranol is an alternative therapy to topical diphencyprone for extensive AA, with the advantage that it can be applied at home. It is also safe in children and has low risk for use during pregnancy. Its precise mechanism of action is unknown, but it is plausible that the local cytokine profile induced by its irritant effect "compete" with the inflammatory milieu incited during the inflammatory cell attack on hair follicles. Read More
J Dermatol 2018 Dec 7. Epub 2018 Dec 7.
Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.
Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. Read More
Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.
Joy Dermatological Clinic, Yamaguchi, Japan.
Hum Genet 2018 Dec 8. Epub 2018 Dec 8.
Hearing and Genes, Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
ATP2B2 encodes the PMCA2 Ca pump that plays an important role in maintaining ion homeostasis in hair cells among others by extrusion of Ca from the stereocilia to the endolymph. Several mouse models have been described for this gene; mice heterozygous for loss-of-function defects display a rapidly progressive high-frequency hearing impairment. Up to now ATP2B2 has only been reported as a modifier, or in a digenic mechanism with CDH23 for hearing impairment in humans. Read More