32,740 results match your criteria Hair Anatomy


Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos.

Chemosphere 2020 May 27;257:127170. Epub 2020 May 27.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address:

Ammonia (including NH and NH) is a major pollutant of freshwater environments. However, the toxic effects of ammonia on the early stages of fish are not fully understood, and little is known about the effects on the sensory system. In this study, we hypothesized that ammonia exposure can cause adverse effects on embryonic development and impair the lateral line system of fish. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127170DOI Listing

Hair-bearing human skin generated entirely from pluripotent stem cells.

Nature 2020 Jun 3. Epub 2020 Jun 3.

Department of Otolaryngology, Boston Children's Hospital, Boston, MA, USA.

The skin is a multilayered organ, equipped with appendages (that is, follicles and glands), that is critical for regulating body temperature and the retention of bodily fluids, guarding against external stresses and mediating the sensation of touch and pain. Reconstructing appendage-bearing skin in cultures and in bioengineered grafts is a biomedical challenge that has yet to be met. Here we report an organoid culture system that generates complex skin from human pluripotent stem cells. Read More

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http://dx.doi.org/10.1038/s41586-020-2352-3DOI Listing

Rapid adjustment of leaf angle explains how the desert moss, Syntrichia caninervis, copes with multiple resource limitations during rehydration.

Funct Plant Biol 2014 Feb;41(2):168-177

Department of Plant and Wildlife Sciences, Brigham Young University, Provo, UT 84602, USA.

Although the desert moss Syntrichia caninervis Mitt. is extremely desiccation tolerant, it still requires water and photosynthates for growth. The ecological significance of the leaf angle in maintaining a balance between water and light availability is critical to its survival. Read More

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http://dx.doi.org/10.1071/FP13054DOI Listing
February 2014

Riveting hammer vibration damages mechanosensory nerve endings.

J Peripher Nerv Syst 2020 May 22. Epub 2020 May 22.

Cell Biology, Neurobiology & Anatomy, Medical College of WI, Milwaukee, Wisconsin, USA.

Background And Aims: Hand-arm vibration syndrome (HAVS) is an irreversible neurodegenerative, vasospastic and musculoskeletal occupational disease of workers using powered hand tools. The etiology is poorly understood. Neurological symptoms include numbness, tingling and pain. Read More

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http://dx.doi.org/10.1111/jns.12393DOI Listing

A multi-isotope, multi-tissue study of colonial origins and diet in New Zealand.

Am J Phys Anthropol 2020 May 18:e24077. Epub 2020 May 18.

Department of Earth Sciences, Durham University, Durham, UK.

Objectives: Colonial period New Zealand was lauded as a land of plenty, where colonists could improve their station in life and secure a future for their families. Our understanding of colonial experience, however, is often shaped by historical records which communicate a state-sponsored version of history. This study aims to reconstruct the lives of settlers using isotopic evidence from the colonial skeletons themselves. Read More

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http://dx.doi.org/10.1002/ajpa.24077DOI Listing

Strigolactones Control Root System Architecture and Tip Anatomy in L. Plants under P Starvation.

Plants (Basel) 2020 May 11;9(5). Epub 2020 May 11.

Dipartimento di Scienze Agrarie, Forestali e Alimentari (DISAFA), Largo Paolo Braccini 2 (già Via Leonardo da Vinci, 44), 10095 Grugliasco (Torino), Italy.

The hormones strigolactones accumulate in plant roots under phosphorus (P) shortage, inducing variations in plant phenotype. In this study, we aimed at understanding whether strigolactones control morphological and anatomical changes in tomato ( L.) roots under varying P supply. Read More

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http://dx.doi.org/10.3390/plants9050612DOI Listing

Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal.

Hear Res 2020 Apr 26;392:107973. Epub 2020 Apr 26.

Institute of Neuroscience of Castilla y León (INCYL), University of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain; Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain. Electronic address:

Rodent models of audiogenic seizures, in which seizures are precipitated by an abnormal response of the brain to auditory stimuli, are crucial to investigate the neural bases underlying ictogenesis. Despite significant advances in understanding seizure generation in the inferior colliculus, namely the epileptogenic nucleus, little is known about the contribution of lower auditory stations to the seizure-prone network. Here, we examined the cochlea and cochlear nucleus of the genetic audiogenic seizure hamster from Salamanca (GASH/Sal), a model of reflex epilepsy that exhibits generalized tonic-clonic seizures in response to loud sound. Read More

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http://dx.doi.org/10.1016/j.heares.2020.107973DOI Listing

Pre-operative hormone stimulation in hypospadias repair: A facilitator or a confounder.

J Pediatr Urol 2020 Apr 21. Epub 2020 Apr 21.

Pediatric Surgery, Mashhad University of Medical Sciences, Iran. Electronic address:

Introduction: Preoperative hormone stimulation (PHS) is popular in hypospadias reconstructive surgery. While still controversial, it is performed to have a more developed gross anatomy of the glans and penis for improvement of the surgical condition and outcome.

Objective: In this study we assessed morphometric and histologic effects of pre-operative testosterone therapy on the penis and prepuce in patients with hypospadias. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.04.012DOI Listing

Mucocutaneous Manifestations of Scurvy.

N Engl J Med 2020 May;382(20):e56

University of Arkansas for Medical Sciences, Little Rock, AR

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http://dx.doi.org/10.1056/NEJMicm1911315DOI Listing

Cisplatin-induced ototoxicity in organotypic cochlear cultures occurs independent of gap junctional intercellular communication.

Cell Death Dis 2020 May 11;11(5):342. Epub 2020 May 11.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.

Cisplatin is a very effective chemotherapeutic, but severe and permanent hearing loss remains a prevalent side effect. The processes underpinning cisplatin-induced ototoxicity are not well understood. Gap junction channels composed of connexin (Cx) subunits allow for the passage of small molecules and ions between contacting neighboring cells. Read More

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http://dx.doi.org/10.1038/s41419-020-2551-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214471PMC

MR Imaging of Hair and Scalp for the Evaluation of Androgenetic Alopecia.

Magn Reson Med Sci 2020 May 1. Epub 2020 May 1.

Department of Radiology, National Defense Medical College.

Purpose: Although androgenetic alopecia (AGA) is a common cause of hair loss, little is known regarding the magnetic resonance imaging (MRI) of the AGA or scalp. This study aimed to analyze whether MRI for hair and scalp (MRH) can evaluate anatomical changes in the scalp caused by AGA.

Methods: Twenty-seven volunteers were graded for the severity of AGA using the Hamilton-Norwood Scale (HNS), commonly used classification system. Read More

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http://dx.doi.org/10.2463/mrms.mp.2020-0026DOI Listing

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis.

Exp Dermatol 2020 May 4. Epub 2020 May 4.

Monasterium Laboratory Skin & Hair Research Solutions GmbH, Münster, Germany.

Epidermal energy metabolism is relevant to skin physiology, ageing and photodamage. While selected hormones stimulate epidermal keratinocyte mitochondrial activity, its negative regulation remains unknown. In several cell types, cannabinoid receptor 1 (CB ) is expressed both on the cell membrane (cmCB ) and on the mitochondrial outer membrane (mtCB ), where its stimulation directly suppresses mitochondrial functions. Read More

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http://dx.doi.org/10.1111/exd.14110DOI Listing
May 2020
3.762 Impact Factor

Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells.

Proc Natl Acad Sci U S A 2020 May 1;117(20):11109-11117. Epub 2020 May 1.

Department of Pharmacology, Yonsei University College of Medicine, 03722 Seoul, Korea;

Outer hair cells (OHCs) play an essential role in hearing by acting as a nonlinear amplifier which helps the cochlea detect sounds with high sensitivity and accuracy. This nonlinear sound processing generates distortion products, which can be measured as distortion-product otoacoustic emissions (DPOAEs). The OHC stereocilia that respond to sound vibrations are connected by three kinds of extracellular links: tip links that connect the taller stereocilia to shorter ones and convey force to the mechanoelectrical transduction channels, tectorial membrane-attachment crowns (TM-ACs) that connect the tallest stereocilia to one another and to the overlying TM, and horizontal top connectors (HTCs) that link adjacent stereocilia. Read More

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http://dx.doi.org/10.1073/pnas.1920229117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245111PMC

IL12B and IL23R polymorphisms are associated with alopecia areata.

Genes Immun 2020 May 1. Epub 2020 May 1.

Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Alopecia areata is an autoimmune disease in which activation of autoreactive T cells and inflammatory immune signals target the hair follicles autoantigens. Although cytokines are involved in regulating autoimmune inflammation, the specific involvement of these molecules in the pathogenesis of alopecia areata has been remained unsettled. Here, a possible influence of IL12B, IL17A, and IL23R variations on susceptibility to alopecia areata in Iranian patients was investigated. Read More

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http://dx.doi.org/10.1038/s41435-020-0100-1DOI Listing

TRPS1 mutation associated with trichorhinophalangeal syndrome type 1 with 15 supernumerary teeth, hypoplastic mandibular condyles with slender condylar necks and unique hair morphology.

J Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Division of Orthodontics, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Trichorhinophalangeal syndrome type 1 (TRPS1; Online Mendelian Inheritance in Man #190350) is an autosomal dominant disorder caused by mutations in TRPS1. We report a Thai male with TRPS1 who carried a c.1842C>T (p. Read More

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http://dx.doi.org/10.1111/1346-8138.15360DOI Listing

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.

Front Aging Neurosci 2020 9;12:83. Epub 2020 Apr 9.

Molecular Physiology of Hearing, Tübingen Hearing Research Centre, Department of Otolaryngology, University of Tübingen, Tübingen, Germany.

In the inner ear, cyclic guanosine monophosphate (cGMP) signaling has been described as facilitating otoprotection, which was previously observed through elevated cGMP levels achieved by phosphodiesterase 5 inhibition. However, to date, the upstream guanylyl cyclase (GC) subtype eliciting cGMP production is unknown. Here, we show that mice with a genetic disruption of the gene encoding the cGMP generator GC-A, the receptor for atrial and B-type natriuretic peptides, display a greater vulnerability of hair cells to hidden hearing loss and noise- and age-dependent hearing loss. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160671PMC

Alteration of the Dopamine Receptors' Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked-Ataxia ()) Mouse.

Int J Mol Sci 2020 Apr 21;21(8). Epub 2020 Apr 21.

Cellular and Molecular Research Center, Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.

A spontaneous mutation in the lysosomal acid phosphatase () enzyme (: naked-ataxia) in experimental mice results in delayed hair appearance and severe cytoarchitectural impairments of the cerebellum, such as a Purkinje cell (PC) migration defect. In our previous investigation, our team showed that Acp2 expression plans a significant role in cerebellar development. On the other hand, the dopaminergic system is also a player in central nervous system (CNS) development, including cerebellar structure and function. Read More

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http://dx.doi.org/10.3390/ijms21082914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215910PMC
April 2020
2.862 Impact Factor

Keratin - Based materials for biomedical applications.

Bioact Mater 2020 Sep 16;5(3):496-509. Epub 2020 Apr 16.

Department of Anatomy, School of Biomedical Sciences University of Otago, Otago, 9016, New Zealand.

Keratin constitutes the major component of the feather, hair, hooves, horns, and wool represents a group of biological material having high cysteine content (7-13%) as compared to other structural proteins. Keratin -based biomaterials have been investigated extensively over the past few decades due to their intrinsic biological properties and excellent biocompatibility. Unlike other natural polymers such as starch, collagen, chitosan, the complex three-dimensional structure of keratin requires the use of harsh chemical conditions for their dissolution and extraction. Read More

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http://dx.doi.org/10.1016/j.bioactmat.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171262PMC
September 2020

Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.

Life Sci 2020 Jul 15;252:117667. Epub 2020 Apr 15.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, Jilin 130112, People's Republic of China. Electronic address:

Aims: Pantothenic acid (PA) has been applied to treat alopecia, but the underlying mechanism is still unclear. Our study aims to explore the underlying mechanism of PA in regulating hair follicle (HF) growth.

Main Methods: Mink HFs and dermal papilla (DP) cells were isolated and cultured in vitro. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117667DOI Listing

Immunostaining study of cytokeratins in human hair follicle development.

An Bras Dermatol 2020 May - Jun;95(3):278-282. Epub 2020 Mar 21.

Graduate Program in Medicine and Health, Faculty of Medicine of Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil; Department of Dermatology, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil.

Background: The hair follicle is a unique structure, one of the most dynamic structures in mammalians, which can reproduce in every new cycle all the mechanism involved in its fetal development. Although a lot of research has been made about the human hair follicle much less has been discovered about the importance of the cytokeratins (CKs) in its development.

Objective: Study the immunohistochemical pattern of epithelial CKs during human hair follicle development. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253916PMC

Repeated Orotracheal Intubation in Mice.

J Vis Exp 2020 Mar 27(157). Epub 2020 Mar 27.

Department of Veterinary Biosciences, The Ohio State University;

The literature describes several methods for mouse intubation that either require visualization of the glottis through the oral cavity or incision in the ventral neck for direct confirmation of cannula placement in the trachea. The relative difficulty or the tissue trauma induced to the subject by such procedures can be an impediment to an investigator's ability to perform longitudinal studies. This article illustrates a technique in which physical manipulation of the mouse following the use of a depilatory to remove hair from the ventral neck permits transcutaneous visualization of the trachea for orotracheal intubation regardless of degree of skin pigmentation. Read More

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http://dx.doi.org/10.3791/60844DOI Listing

Tinea capitis: dermoscopy and calcium fluorescent microscopy as highly efficient and precise diagnostic tools.

An Bras Dermatol 2020 May - Jun;95(3):332-335. Epub 2020 Mar 19.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Tinea capitis comprising of tinea favosa and kerion is mostly seen in school-aged children. Some tinea capitis often presented with insignificant findings under the naked eyes are easily overlooked. The authors describe an unusual case of tinea capitis caused by Trichophyton violaceum. Read More

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http://dx.doi.org/10.1016/j.abd.2019.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253880PMC

Temporary Relocation during Rest Periods: Relocation Stress and Other Factors Influence Hair Cortisol Concentrations in Horses.

Animals (Basel) 2020 Apr 8;10(4). Epub 2020 Apr 8.

Department of Animal Health and Anatomy, Veterinary Faculty, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain.

Horse transportation for temporary relocation during rest periods is a common and widespread practice among horse owners, either from sport competition or working tasks. This study aimed to determine the effect of a relocation period and the multiple factors associated with a rest period on hair cortisol concentrations (HCCs) in horses. Additionally, this study reports the seasonal effect on HCCs and hair growth over a year. Read More

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http://dx.doi.org/10.3390/ani10040642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222751PMC

Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France and Department of Pathology, Centre Hospitalier Lyon Sud, Pierre Bénite.

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as 'comedo nevus' and renamed 'PEODDN'; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and hair follicle nevus, and porokeratotic adnexal ostial nevus. PEODDN is usually present at birth or develops early in life. Rarely, PEODDN can develop in adults. Read More

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February 2020

Gram-negative infections in patients with folliculitis decalvans: a subset of patients requiring alternative treatment.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, Kaiser-Permanente Northern California, Stockton, CA.

Background Folliculitis decalvans is a neutrophilic cicatricial alopecia whose etiology remains unknown. It is frequently associated with staphylococcal infections. We aimed to determine the rate of gram-negative infections in patients with folliculitis decalvans. Read More

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February 2020

[Genetic variant analysis of a pedigree affected with lymphedema-distichiasis syndrome].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Apr;37(4):434-437

Department of Clinical Genetics, Huaian Maternal and Child Health Care Hospital, Huaian, Jiangsu 223002, China.

Objective: To analyze FOXC2 gene variant in a family affected with lymphodema-distichiasis syndrome (LDS).

Methods: Peripheral blood samples were collected for the extraction of DNA and protein. Whole-exome sequencing was carried out to detect variants in the proband. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.04.017DOI Listing

Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat.

Int J Mol Sci 2020 Mar 25;21(7). Epub 2020 Mar 25.

State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.

Increasing cashmere yield is one of the important goals of cashmere goat breeding. To achieve this goal, we screened the key genes that can improve cashmere performance. In this study, we used the RNA raw datasets of the skin and dermal papilla cells of secondary hair follicle (SHF-DPCs) samples of hair follicle (HF) anagen and telogen of Albas cashmere goats and identified a set of significant differentially expressed genes (DEGs). Read More

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http://dx.doi.org/10.3390/ijms21072268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177334PMC

The Effect of Light on Plastid Differentiation, Chlorophyll Biosynthesis, and Essential Oil Composition in Rosemary () Leaves and Cotyledons.

Front Plant Sci 2020 3;11:196. Epub 2020 Mar 3.

Department of Plant Anatomy, ELTE Eötvös Loránd University, Budapest, Hungary.

It is unclear whether light affects the structure and activity of exogenous secretory tissues like glandular hairs. Therefore, transmission electron microscopy was first used to study plastid differentiation in glandular hairs and leaves of light-grown rosemary ( "Arp") plants kept for 2 weeks under ambient light conditions. During our detailed analyses, among others, we found leucoplasts with tubuloreticular membrane structures resembling prolamellar bodies in stalk cell plastids of peltate glandular hairs. Read More

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http://dx.doi.org/10.3389/fpls.2020.00196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063033PMC

New age-related hearing loss candidate genes in humans: an ongoing challenge.

Gene 2020 Jun 12;742:144561. Epub 2020 Mar 12.

Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Age-related hearing loss (ARHL) is the most frequent sensory disorder in the elderly, affecting approximately one-third of people aged more than 65 years. Despite a large number of people affected, ARHL is still an area of unmet clinical needs, and only a few ARHL susceptibility genes have been detected so far. In order to further investigate the genetics of ARHL, we analyzed a series of 46 ARHL candidate genes, selected according to previous Genome Wide Association Studies (GWAS) data, literature updates and animal models, in a large cohort of 464 Italian ARHL patients. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144561DOI Listing

Using Sox2 to alleviate the hallmarks of age-related hearing loss.

Ageing Res Rev 2020 May 12;59:101042. Epub 2020 Mar 12.

Department of Biology, CLAS, University of Iowa, Iowa City, USA. Electronic address:

Age-related hearing loss (ARHL) is the most prevalent sensory deficit. ARHL reduces the quality of life of the growing population, setting seniors up for the enhanced mental decline. The size of the needy population, the structural deficit, and a likely research strategy for effective treatment of chronic neurosensory hearing in the elderly are needed. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261488PMC
May 2020
4.940 Impact Factor

Melanonychia associated with subungual follicular inclusions: report of three cases.

An Bras Dermatol 2020 Mar - Apr;95(2):217-220. Epub 2020 Feb 12.

Dermatology Service, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. Read More

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http://dx.doi.org/10.1016/j.abd.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175037PMC

Idiopathic follicular mucinosis in childhood.

An Bras Dermatol 2020 Mar - Apr;95(2):268-270. Epub 2020 Feb 18.

Department of Dermatology, Centro Universitário Lusíada, Santos, SP, Brazil.

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http://dx.doi.org/10.1016/j.abd.2019.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175403PMC

Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature.

BMC Med Genet 2020 03 14;21(1):52. Epub 2020 Mar 14.

Section of General Surgery and Gastrointestinal Surgery, Department of Surgery I, Faculdade de Medicina do ABC, Avenida Lauro Gomes, 2000, Santo André/São Paulo, CEP 09060-870, Brazil.

Background: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by benign growth of the hair follicles, the presence of pulmonary cysts, spontaneous pneumothorax, and bilateral renal tumors that are usually hybrid oncocytic or multifocal chromophobe renal cell carcinoma. The diagnosis is confirmed by the presence of a pathogenic variant in the tumor suppressor folliculin (FLCN) gene mapped at 17p11.2. Read More

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http://dx.doi.org/10.1186/s12881-020-0991-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071710PMC

Macroanatomical and histological study of the structure of ıntercornual gland in Abaza (Capra Aegagrus) and Georgian (Capra Falconeri) goats breeds.

Folia Morphol (Warsz) 2020 Mar 11. Epub 2020 Mar 11.

Department of Histology and Embryology, Faculty of Veterinary Medicine, Kafkas University,36100, Kars, Turkey.

The anatomical localization of the odor glands, which increase activity during the reproduction period and help goat species to find each other, varies. In our study, the anatomical and histological structures of the glands around the horn were examined in the Georgian and Abaza goats, which are native breeds. In this study a total of 12 Abaza and Georgian goat heads were used. Read More

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http://dx.doi.org/10.5603/FM.a2020.0028DOI Listing

Pilomatrix carcinoma of the lacrimal caruncle: a case report.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):153-156

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. Read More

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http://dx.doi.org/10.5935/0004-2749.20200029DOI Listing

Apparent darkening of scalp hair related to pili multigemini Following dabrafenib and trametinib.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Division of Dermatology, The Ohio State University Department of Internal Medicine, Columbus, OH.

The combination of dabrafenib and trametinib is an important immunotherapy option for patients with BRAF V600 mutation-positive melanoma. This regimen has been reported to cause cutaneous eruptions. However, hair dysmorphology is not a reported side effect to these or any other medications to date. Read More

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January 2020

Woolly hair nevus: case report and review of literature.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Dermatology, Centro Hospitalar de Leiria, Leiria.

Woolly hair nevus consists of a patch of curly and hypopigmented hair that is restricted to an area of the scalp. It is usually benign but it can be associated with other systemic findings. Trichoscopy and dermoscopy may be useful when analyzing this entity. Read More

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January 2020

Histopathological changes in epithelium of hair follicles and acrosyringium caused by measles in child.

An Bras Dermatol 2020 Mar - Apr;95(2):238-240. Epub 2020 Feb 12.

Universidade Federal do Amazonas, Manaus, AM, Brazil.

Some epidermal alterations in measles has been described, such as keratinocytes apoptotic, parakeratosis, giant-cell formation, intranuclear and cytoplasmic inclusions, dyskeratosis, spongiosis, and intracellular edema. The authors report for the first time in human a case of measles with the presence of multinucleated giant cells in the hair follicle and dyskeratosis in acrosyringium. Read More

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http://dx.doi.org/10.1016/j.abd.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175039PMC

The anatomy of the skin of the Chinese tree shrew is very similar to that of human skin.

Zool Res 2020 Mar;41(2):208-212

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.

The Chinese tree shrew () is a small mammal closely related to primates. It has a small body size, low maintenance cost, and a relatively short reproductive cycle, all of which has made it the ideal model for the study of a variety of human diseases. In this study, we compared the anatomy of the skin of the Chinese tree shrew with that of the rhesus macaque, mouse and human, with the intention of providing the basic data required for the creation of skin disease models using this animal. Read More

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http://dx.doi.org/10.24272/j.issn.2095-8137.2020.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109020PMC

Risk Factors Associated with Premature Hair Greying of Young Adult.

Open Access Maced J Med Sci 2019 Nov 14;7(22):3762-3764. Epub 2019 Nov 14.

Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia.

Background: Many researchers have been indicated that premature hair greying (PHG) may be associated with the multifactorial problem include genetic, trace elements deficiencies and some medical problems such as metabolic disorders. However, the risk factors for premature hair greying are not well known for young adult.

Aim: This study aimed to determine the risk factors of hair greying in young adult. Read More

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http://dx.doi.org/10.3889/oamjms.2019.498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048355PMC
November 2019

Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging.

PLoS One 2020 2;15(3):e0226860. Epub 2020 Mar 2.

Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

The mitochondrial theory of aging attributes much of the aging process to mitochondrial DNA damage. The polymerase gamma (PolG) mutant mouse was designed to evaluate this theory and thus carries a mutated proofreading region of polymerase gamma (D257A) that exclusively transcribes the mitochondrial genome. As a result, PolGD257A mice accumulate mitochondrial DNA (mtDNA) mutations that lead to premature aging, as evidenced by hair loss, weight loss, kyphosis, increased rates of apoptosis, organ damage, and an early death, occurring around 12 months of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051064PMC

The Molecular Anatomy of Mouse Skin during Hair Growth and Rest.

Cell Stem Cell 2020 Mar 27;26(3):441-457.e7. Epub 2020 Feb 27.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. Electronic address:

Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing and single-molecule RNA FISH to provide a systematic molecular atlas of full-thickness skin, determining gene expression profiles and spatial locations that define 56 cell types and states during hair growth and rest. These findings reveal how the outer root sheath (ORS) and inner hair follicle layers coordinate hair production. Read More

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http://dx.doi.org/10.1016/j.stem.2020.01.012DOI Listing

Olig2 positive cells derived from hair follicle neural crest stem cells in rats.

J Chem Neuroanat 2020 Apr 20;105:101770. Epub 2020 Feb 20.

Department of Anatomy, the Second Military Medical University/Naval Medical University, China.

Motor neuron disease (MND) is a kind of common clinical nervous system disease with typical characteristic of progressive motor neurons degeneration or death. Motor neuron derived from stem cells or motor neuron progenitor cells will be a good choice to be used for treatment of the disease. In this study, we used the combination of 5 small molecular including CHIR99021 (CHIR), SB431542 (SB), DMH1 (DMH), retinoic acid (RA) and Purmorphamine (Pur) to induce hair follicles neural crest stem cells (hfNCSCs) to motor neurons progenitors (MNPs). Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101770DOI Listing
April 2020
2.520 Impact Factor

Pilomatrix Carcinoma: A Rare Hair Cell Tumor.

Am Surg 2020 Jan;86(1):e38-e39

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January 2020

[Research progress on the correlation between the structural and functional variation of cochlea inner hair cells and frequency tuning].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;55(2):176-181

Department of Otorhinolaryngology, Chongqing General Hospital, Chongqing 400038, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2020.02.020DOI Listing
February 2020

Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia.

Biomed Res Int 2020 27;2020:7397162. Epub 2020 Jan 27.

Institute of Dermatology, F. Policlinico Gemelli IRCSS, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy.

Tissue engineering in hair regrowth aims to develop innovative and not-invasive procedures to advance the hair regrowth. A placebo-controlled, randomized, evaluator-blinded, half-head group study to compare hair regrowth with micrografts containing human hair follicle mesenchymal stem cells (HF-MSCs) vs. placebo was reported. Read More

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http://dx.doi.org/10.1155/2020/7397162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007958PMC
January 2020

Functional anatomy of the middle and inner ears of the red fox, in comparison to domestic dogs and cats.

J Anat 2020 Jun 18;236(6):980-995. Epub 2020 Feb 18.

Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.

Anatomical middle and inner ear parameters are often used to predict hearing sensitivities of mammalian species. Given that ear morphology is substantially affected both by phylogeny and body size, it is interesting to consider whether the relatively small anatomical differences expected in related species of similar size have a noticeable impact on hearing. We present a detailed anatomical description of the middle and inner ears of the red fox Vulpes vulpes, a widespread, wild carnivore for which a behavioural audiogram is available. Read More

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http://dx.doi.org/10.1111/joa.13159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219625PMC

Notch Signalling: The Multitask Manager of Inner Ear Development and Regeneration.

Adv Exp Med Biol 2020 ;1218:129-157

University College London, The Ear Institute, London, UK.

Notch signalling is a major regulator of cell fate decisions and tissue patterning in metazoans. It is best known for its role in lateral inhibition, whereby Notch mediates competitive interactions between cells to limit adoption of a given developmental fate. However, it can also function by lateral induction, a cooperative mode of action that was originally described during the patterning of the Drosophila wing disc and creates boundaries or domains of cells of the same character. Read More

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http://dx.doi.org/10.1007/978-3-030-34436-8_8DOI Listing

Role of Free Radical Formation in Murine Cytomegalovirus-Induced Hearing Loss.

Otolaryngol Head Neck Surg 2020 May 11;162(5):709-717. Epub 2020 Feb 11.

College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.

Objectives: The goal of the study was to determine whether reactive oxygen species (ROS) mediates cytomegalovirus (CMV)-induced labyrinthitis.

Study Design: Murine model of CMV infection.

Setting: University of Utah laboratory. Read More

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http://dx.doi.org/10.1177/0194599820901485DOI Listing