31,258 results match your criteria Hair Anatomy


Attraction of the sandfly Lutzomyia longipalpis to possible biomarker compounds from dogs infected with Leishmania infantum.

Med Vet Entomol 2019 Jan 16. Epub 2019 Jan 16.

Laboratory of Veterinary Infectious Diseases, Teaching Hospital of Veterinary Medicine, Federal University of Bahia (UFBA), Salvador, BA, Brazil.

Lutzomyia longipalpis (Diptera: Psychodidae) is the primary vector of Leishmania infantum (Kinetoplastida: Trypanosomatidae) in the Americas. Studies have been carried out to identify new alternatives for monitoring and controlling this sandfly species, particularly with the use of chemical baits. The attractiveness of odours emitted by foxes and alcohols found in some plants has already been demonstrated in laboratory tests with Lu. Read More

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http://dx.doi.org/10.1111/mve.12357DOI Listing
January 2019

Histological and functional comparisons of four anatomical regions of porcine skin with human abdominal skin.

Anat Histol Embryol 2019 Jan 16. Epub 2019 Jan 16.

Department of Veterinary Medicine, Institute for Veterinary Anatomy, Freie Universität Berlin, Berlin, Germany.

Because of the shortage of human skin for research purposes, porcine skin has been used as a model of human skin. The aim of this study was to identify the region of German Landrace pig skin that could be used as the best possible substitute for human abdominal skin. Porcine samples were collected from the ear, flank, back and caudal abdomen; human abdominal skin samples were excised during plastic surgery. Read More

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http://dx.doi.org/10.1111/ahe.12425DOI Listing
January 2019
1 Read

Correction to: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing.

Mol Neurobiol 2019 Jan 14. Epub 2019 Jan 14.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea.

The original article contains an error for a grant number in the Acknowledgements section. Read More

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http://dx.doi.org/10.1007/s12035-019-1470-0DOI Listing
January 2019

Premature aging and cancer development in transgenic mice lacking functional CYLD.

Aging (Albany NY) 2019 Jan;11(1):127-159

Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)/CIBERONC, Madrid 28040, Spain.

CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes, protects from premature aging and cancer. We have generated transgenic mice expressing the mutant CYLD protein, lacking its deubiquitinase function, under the control of the keratin 5 promoter, the K5-CYLD mice. Read More

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http://www.aging-us.com/article/101732/text
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http://dx.doi.org/10.18632/aging.101732DOI Listing
January 2019
2 Reads

Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways.

Biol Pharm Bull 2019 ;42(1):139-143

Department of Medicine, School of Medicine, Jeju National University.

Norgalanthamine has been shown to possess hair-growth promoting effects, including increase in hair-fiber length in cultured rat vibrissa follicles and increase in dermal papilla cell (DPC) proliferation. However, the intracellular mechanisms that underlie the action of norgalanthamine in DPCs have not been investigated. In this study, we addressed the ability of norgalanthamine to trigger anagen-activating signaling pathways in DPCs. Read More

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https://www.jstage.jst.go.jp/article/bpb/42/1/42_b18-00226/_
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http://dx.doi.org/10.1248/bpb.b18-00226DOI Listing
January 2019
6 Reads
1.778 Impact Factor

A novel mutation of SGSH and clinical features analysis of mucopolysaccharidosis type IIIA.

Medicine (Baltimore) 2018 Dec;97(52):e13758

Department of Gastroenterology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, P.R. China.

Rationale: The aim of this study was to analyze the clinical and imaging features of a pediatric patient with mucopolysaccharidosis type IIIA (MPS IIIA) and a novel mutation of the N-sulfoglucosamine sulfohydrolase (SGSH) in 1 pedigree.

Patient Concerns: An 8-year-old female patient presented with developmental regression, seizures, cerebral atrophy, thickened calvarial diploe, apathy, esotropia, slender build, thick hair, prominent eyebrows, hepatomegaly, ankle clonus, muscle and joint contractures, and funnel chest.

Diagnoses: The patient was diagnosed as autosomal recessive (AR) MPS IIIA with a novel mutation in the SGSH gene. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0002
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http://dx.doi.org/10.1097/MD.0000000000013758DOI Listing
December 2018
6 Reads

Regional skin histomorphology in adult greater cane rats (): A pilot study.

Int J Vet Sci Med 2018 Dec 16;6(2):219-226. Epub 2018 Nov 16.

Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.

The greater cane rat () demonstrated numerous dermal architectural peculiarities hitherto unreported. This investigation assessed and evaluated certain histologic features of skin samples from the fore and hind limbs, the neck, head, proximal to the ear and oro-nasal regions for follicular evaluations and micro anatomic assessments in the adult species. Twenty wild taken animals of equal gender distribution were used for histologic assessments of structural elements and histo-morphometric evaluations. Read More

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http://dx.doi.org/10.1016/j.ijvsm.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286415PMC
December 2018

The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss.

J Cell Sci 2019 Jan 16;132(2). Epub 2019 Jan 16.

Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada

Mutations in the genes that encode the gap junction proteins connexin 26 (Cx26, encoded by ) and Cx30 () are the leading cause of hereditary hearing loss. That said, the Cx30 p.Ala88Val (A88V) mutant causes Clouston syndrome, but not hearing loss. Read More

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http://dx.doi.org/10.1242/jcs.224097DOI Listing
January 2019
1 Read

A patient with pilomatricoma in the parotid region: case report and review of the literature.

Rom J Morphol Embryol 2018 ;59(3):917-926

Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;

Pilomatricoma is a benign skin tumor originating from the matrix cells of the hair follicles. Sometimes, its diagnosis can be difficult, especially in the preauricular region, where in the differential diagnosis, in addition to other dermal and subcutaneous masses, primary and secondary parotid gland tumor lesions must be also considered. A 34-year-old female was referred to our Institution with a right preauricular swelling over 12 months, which enlarged in the last two months. Read More

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January 2019
5 Reads

A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss.

Int J Nanomedicine 2018 14;13:7517-7531. Epub 2018 Nov 14.

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China,

Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity.

Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs). Read More

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http://dx.doi.org/10.2147/IJN.S170130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241721PMC
January 2019

PDL2 CD11b dermal dendritic cells capture topical antigen through hair follicles to prime LAP Tregs.

Nat Commun 2018 12 7;9(1):5238. Epub 2018 Dec 7.

Pediatric Allergy & Immunology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits immune tolerance that can suppress colitis and food allergy. Here we show how topical antigen is acquired and presented by dendritic cells in the skin. Read More

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http://dx.doi.org/10.1038/s41467-018-07716-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286332PMC
December 2018
6 Reads

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Redox Biol 2019 Jan 20;20:544-555. Epub 2018 Nov 20.

Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Mitochondrial NADP-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency induces mitochondrial dysfunction and modulates auditory function, and investigated the protective potential of an antioxidant agent against reactive oxygen species (ROS)-induced cochlear damage in Idh2 knockout (Idh2) mice. Idh2 deficiency leads to damages to hair cells and spiral ganglion neurons (SGNs) in the cochlea and ultimately to apoptotic cell death and progressive sensorineural hearing loss in Idh2 mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183072
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http://dx.doi.org/10.1016/j.redox.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279977PMC
January 2019
18 Reads

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.

Cell Rep 2018 Dec 30;25(11):2981-2991.e3. Epub 2018 Nov 30.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address:

Haired skin is a defining characteristic of mammals. However, some specialized skin regions, such as human palms, soles and ventral wrist, and mouse plantar foot, are entirely hairless. Using mouse plantar skin as a model system, we show that the endogenous secreted Wnt inhibitor DKK2 suppresses plantar hair follicle development and permits the formation of hairless skin. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.11.017DOI Listing
December 2018
3 Reads

Eyelash hair transplantation with strip composite eyebrow graft: an enhancing technique in tarsoconjunctival flap eyelid reconstruction procedure.

Orbit 2018 Nov 27:1-4. Epub 2018 Nov 27.

a Oculoplastics Department , Instituto de Oftalmología Fundación Conde de Valenciana , Mexico City , Mexico.

Purpose: To describe and evaluate the eyelash transplantation with strip composite eyebrow graft to improve eyelid anatomy in tarsoconjunctival flap eyelid reconstruction procedure.

Methods: Twenty two patients with eyelid tumors managed by local excision and reconstruction using tarsoconjunctival flap reconstruction procedure were included. Eyelash graft was performed during flap division by harvesting a graft from the eyebrow and creating a recipient pocket in the receptor eyelid. Read More

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http://dx.doi.org/10.1080/01676830.2018.1546324DOI Listing
November 2018

Ultrastructure features of the surface of the gills and the lower pharyngeal jaw of the Tilapia Zilli, redbelly tilapia (Coptodon Zillii, Gervais, 1848).

Anat Histol Embryol 2018 Nov 25. Epub 2018 Nov 25.

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Alexandria University, Behera, Egypt.

The present investigation was designed to describe the surface ultrastructure of the gill system of tilapia Zilli. The gill system is formed from four gill arches and each gill arch carries a row of gill filaments on its convex border and two rows of the gill rakers on its concave border. The quadrilateral interbranchial septum has elevated part at the level of the third gill arch. Read More

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http://dx.doi.org/10.1111/ahe.12406DOI Listing
November 2018

Biochemical and histopathological evaluation of the radioprotective effects of melatonin against Gamma ray-induced skin damage in rats.

Curr Radiopharm 2018 Nov 20. Epub 2018 Nov 20.

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran. Iran.

Background: Radiotherapy is one of the treatment methods for cancers using ionizing radiations. About 70% of cancer patients undergo radiotherapy. Radiation effect on the skin is one of the main complications of radiotherapy and dose limiting factor. Read More

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http://dx.doi.org/10.2174/1874471012666181120163250DOI Listing
November 2018
4 Reads

Helios is a key transcriptional regulator of outer hair cell maturation.

Nature 2018 11 21;563(7733):696-700. Epub 2018 Nov 21.

Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

The sensory cells that are responsible for hearing include the cochlear inner hair cells (IHCs) and outer hair cells (OHCs), with the OHCs being necessary for sound sensitivity and tuning. Both cell types are thought to arise from common progenitors; however, our understanding of the factors that control the fate of IHCs and OHCs remains limited. Here we identify Ikzf2 (which encodes Helios) as an essential transcription factor in mice that is required for OHC functional maturation and hearing. Read More

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http://dx.doi.org/10.1038/s41586-018-0728-4DOI Listing
November 2018
8 Reads

The immunological anatomy of the skin.

Nat Rev Immunol 2019 Jan;19(1):19-30

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Read More

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http://dx.doi.org/10.1038/s41577-018-0084-5DOI Listing
January 2019
6 Reads

Reconstruction of the Forehead and Scalp.

Facial Plast Surg Clin North Am 2019 Feb;27(1):85-94

Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, 240 East 38th Street, 14th Floor, New York, NY 10016, USA. Electronic address:

Tissue inelasticity and the hair-bearing nature of the scalp and forehead pose unique challenges during reconstruction. A thorough understanding of the surgical anatomy of the scalp and forehead is paramount for optimal reconstructive outcomes. Primary wound closure is usually preferred over secondary intention healing and skin grafting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647406183007
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http://dx.doi.org/10.1016/j.fsc.2018.08.009DOI Listing
February 2019
12 Reads

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin.

J Ethnopharmacol 2019 Feb 27;230:81-94. Epub 2018 Oct 27.

Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing 210094, PR China. Electronic address:

Ethnopharmacological Relevance: Polygonum multiflorum Thund., a well-known and commonly-used TCM (Traditional Chinese Medicine) for treating hypertension, hyperlipidemia, premature graying of hair, and etc., has aroused wide concern for its reported potential liver toxicity. Read More

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http://dx.doi.org/10.1016/j.jep.2018.10.032DOI Listing
February 2019

Progressive hearing loss in vitamin A-deficient mice which may be protected by the activation of cochlear melanocyte.

Sci Rep 2018 Nov 6;8(1):16415. Epub 2018 Nov 6.

Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

Vitamin A deficiency (VAD) produces various pathologic phenotypes in humans and animals. However, evidence regarding the effect of VAD on hearing function has been inconsistent. In this study, we evaluated the effect of VAD on hearing function in two mouse models of VAD. Read More

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http://www.nature.com/articles/s41598-018-34653-8
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http://dx.doi.org/10.1038/s41598-018-34653-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219529PMC
November 2018
6 Reads

A study of the intrinsic variability and the effect of environmental conditions on the formation of a postmortem root band.

Forensic Sci Int 2018 Dec 25;293:63-69. Epub 2018 Oct 25.

Counterterrorism and Forensic Science Research Unit, Federal Bureau of Investigation Laboratory Division, 2501 Investigation Parkway, Quantico, VA 22135, United States. Electronic address:

A postmortem root band (PMRB) is defined as "an opaque ellipsoidal band composed of a collection of parallel elongated air/gas spaces and is approximately 0.5mm above the root bulb and about 2mm below the skin surface" [1]. It is generally accepted that it can appear in the root of hairs attached to remains during decomposition [1]. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.09.032DOI Listing
December 2018
10 Reads

Wound healing mechanism in Mongolian gerbil skin.

Histochem Cell Biol 2018 Nov 3. Epub 2018 Nov 3.

Division in Anatomy and Developmental Biology, Department of Oral Biology, Oral Science Research Center, BK21 PLUS Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemoon-Gu, Seoul, 03722, South Korea.

The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). Read More

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http://link.springer.com/10.1007/s00418-018-1752-z
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http://dx.doi.org/10.1007/s00418-018-1752-zDOI Listing
November 2018
6 Reads

Role of microRNAs in inner ear development and hearing loss.

Gene 2019 Feb 31;686:49-55. Epub 2018 Oct 31.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

The etiology of hearing loss tends to be multi-factorial and affects a significant proportion of the global population. Despite the differences in etiology, a common physical pathological change that leads to hearing loss is damage to the mechanosensory hair cells of the inner ear. MicroRNAs (miRNAs) have been shown to play a role in inner ear development and thus, may play a role in the development or prevention of hearing loss. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183112
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http://dx.doi.org/10.1016/j.gene.2018.10.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320273PMC
February 2019
20 Reads

Calyx junction dismantlement and synaptic uncoupling precede hair cell extrusion in the vestibular sensory epithelium during sub-chronic 3,3'-iminodipropionitrile ototoxicity in the mouse.

Arch Toxicol 2018 Oct 30. Epub 2018 Oct 30.

Departament de Ciències Fisiològiques, Institut de Neurociènces, Universitat de Barcelona, Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Catalunya, Spain.

The cellular and molecular events that precede hair cell (HC) loss in the vestibular epithelium during chronic ototoxic exposure have not been widely studied. To select a study model, we compared the effects of sub-chronic exposure to different concentrations of 3,3'-iminodipropionitrile (IDPN) in the drinking water of two strains of mice and of both sexes. In subsequent experiments, male 129S1/SvImJ mice were exposed to 30 mM IDPN for 5 or 8 weeks; animals were euthanized at the end of the exposure or after a washout period of 13 weeks. Read More

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http://dx.doi.org/10.1007/s00204-018-2339-0DOI Listing
October 2018
4 Reads

The effect of ectodermal dysplasia on volume and surface area of maxillary sinus.

Eur Arch Otorhinolaryngol 2018 Dec 20;275(12):2991-2996. Epub 2018 Oct 20.

Private Practice, Kocaeli, Turkey.

Purpose: Ectodermal dysplasia (ED) is a congenital syndrome characterized by abnormal development of ectodermal structures, such as skin, hair, nails, teeth, or salivary glands. Patients with ED demonstrate craniofacial dysmorphology, midfacial hypoplasia and hypodontia. The aim of this study is to evaluate volume and surface area of maxillary sinus and craniofacial structures in patients with ectodermal dysplasia (ED) using cone-beam computed tomography (CBCT) images. Read More

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http://link.springer.com/10.1007/s00405-018-5177-z
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http://dx.doi.org/10.1007/s00405-018-5177-zDOI Listing
December 2018
6 Reads

Effect of Physical and Chemical Hair Removal Methods on Skin Barrier Function in vitro: Consequences for a Hydrophilic Model Permeant.

Skin Pharmacol Physiol 2019 19;32(1):8-21. Epub 2018 Oct 19.

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Background: Although very common in our society, the effect of hair removal on physiological skin parameters and on the ingress of applied chemicals has not been systematically investigated. Thus, as a first step, the aim of the present study was to elucidate the effect of hair removal through epilation (electric epilation, waxing) and depilation (dry and wet shaving, depilatory cream) on skin properties in vitro using the porcine ear model.

Methods: Attenuated total reflection Fourier transform infrared spectroscopy, measurement of the transepidermal water loss (TEWL), visualization by capacitance-based contact imaging, confocal Raman spectroscopy (CRS), diffusion cell studies and tape stripping experiments were employed. Read More

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http://dx.doi.org/10.1159/000493168DOI Listing
January 2019

Details of a thallium poisoning case revealed by single hair analysis using laser ablation inductively coupled plasma mass spectrometry.

Forensic Sci Int 2018 Nov 9;292:224-231. Epub 2018 Oct 9.

P.O. Box 83173, Gaithersburg, Maryland 20883, USA. Electronic address:

Heavy metals pose significant morbidity and mortality threats to humans in connection with both acute and chronic exposure. The often-delayed manifestations of some toxic effects and the wide-spectrum of symptoms caused by heavy metal poisoning may perplex the clinical diagnosis and, when involved in crimes, complicate the forensic investigation. To investigate the original intoxication process of a thallium poisoning case, which occurred in China more than two decades ago, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to analyze several hairs of the victim from before, during and after the poisoning period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03790738183085
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http://dx.doi.org/10.1016/j.forsciint.2018.10.002DOI Listing
November 2018
16 Reads

Usefulness of the skin biopsy as a tool in the diagnosis of silvery hair syndrome.

Pediatr Dermatol 2018 Nov 18;35(6):780-783. Epub 2018 Oct 18.

Department of Dermatology, National Institute of Pediatrics, Mexico City, Mexico.

Background/objectives: Silvery hair syndrome is a rare, autosomal-recessive entity characterized by silvery gray hair, eyebrows, and eyelashes and may be associated or not with immunologic or neurologic alterations. Two main types have been recognized: Chediak-Higashi syndrome and Griscelli syndrome. Hair shaft examination under light microscopy has been a useful tool to differentiate Chediak-Higashi syndrome from Griscelli syndrome, although distribution of melanin varies according to hair color related to ethnicity. Read More

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http://dx.doi.org/10.1111/pde.13624DOI Listing
November 2018
1 Read

Safety concerns when using novel medications to treat alopecia.

Expert Opin Drug Saf 2018 Nov 25;17(11):1115-1128. Epub 2018 Oct 25.

b Department of Dermatology and Cutaneous Surgery , University of Miami Miller School of Medicine , Miami , FL , USA.

Introduction: Alopecia is often a cause of great concern to patients for cosmetic and psychologic reasons. The aim of treating non-scarring alopecias is to reduce hair loss and, to some extent, enhance hair regrowth. However, therapies for scarring alopecias are limited and aiming to halt disease progression. Read More

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https://www.tandfonline.com/doi/full/10.1080/14740338.2018.1
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http://dx.doi.org/10.1080/14740338.2018.1533549DOI Listing
November 2018
38 Reads

Case of newly diagnosed bilateral anorchia in a 42-year-old male patient.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Endocrinology, Hospital de Egas Moniz, Lisbon, Portugal.

A 42-year-old African man presented with hypogonadic phenotypical features, including gynoid body distribution, gynaecomastia, absent facial and truncal hair and micropenis. He denied ever experiencing development of male secondary sex characteristics. Endocrine testing revealed hypergonadotropic hypogonadism and undetectable AMH. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22553
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http://dx.doi.org/10.1136/bcr-2018-225530DOI Listing
October 2018
7 Reads

Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle.

Bone 2018 Oct 11;120:75-84. Epub 2018 Oct 11.

Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health University, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

Wnt10a is a member of the WNT family. Although deficiency of this gene causes symptoms related to teeth, hair, nails, and skin, we recently demonstrated a new phenotype of Wnt10a knockout (KO) mice involving bone and fat. The in vivo effect of the Wnt10a gene on bone and fat is unclear, and the relationship between bone/fat and muscle in Wnt10a signaling is also interesting. Read More

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http://dx.doi.org/10.1016/j.bone.2018.10.009DOI Listing
October 2018
1 Read

Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation.

Environ Toxicol Pharmacol 2018 Dec 29;64:94-100. Epub 2018 Sep 29.

Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address:

Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds for development of oral squamous cell carcinoma and hepatocellular carcinoma via DNA adduction. In innate immunity, macrophages are the predominant cells for non-specific first line defense against pathogens in oral tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689183044
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http://dx.doi.org/10.1016/j.etap.2018.09.012DOI Listing
December 2018
2 Reads

Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants.

Sci Rep 2018 Oct 11;8(1):15151. Epub 2018 Oct 11.

Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.

Prenatal distress is associated with adverse outcomes in affected offspring. Alterations in placental glucocorticoid signalling and subsequent foetal overexposure to glucocorticoids have been implicated as an underlying mechanism. Infant sex is emerging as an important factor in disease susceptibility. Read More

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http://dx.doi.org/10.1038/s41598-018-33357-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181924PMC
October 2018
2 Reads

Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo.

Tissue Cell 2018 Oct 18;54:94-104. Epub 2018 Aug 18.

Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Vavilova 26, 119334, Moscow, Russian Federation; Pirogov Russian National Research Medical University, Ostrovitianova 1, 117997, Moscow, Russian Federation; Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation.

Neural crest stem cells that located in the postnatal hair follicle (HF-NCSC) are considered a promising tool for treatment of nervous system diseases and injuries. It is well known that HF-NCSC can be used in the spinal cord and sciatic nerve reparation but their ability to restore brain structures is poorly studied. In this article we are investigating the interaction between HF-NCSC and a nerve tissue (embryonic and adult). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00408166173041
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http://dx.doi.org/10.1016/j.tice.2018.08.005DOI Listing
October 2018
5 Reads

Cutaneous immunohistochemical staining pattern of p53β isoforms.

J Clin Pathol 2018 Dec 10;71(12):1120-1122. Epub 2018 Oct 10.

Department of Dermatology, School of Medicine, University of Dundee, Dundee, UK.

p53 is considered the guardian of the genome and as such has numerous functions. The gene is the most commonly mutated gene in cancer, and yet the exact biological significance of such mutations remains unclear. There are at least 12 different isoforms of p53, and the complexity of the p53 pathway may be in part related to these isoforms. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205098DOI Listing
December 2018

Spontaneous primary hypothyroidism in 7 adult cats.

J Vet Intern Med 2018 Nov 7;32(6):1864-1873. Epub 2018 Oct 7.

College of Veterinary Medicine, Cornell University, Ithaca, New York.

Background: Naturally occurring hypothyroidism in adult cats is rare, with only 4 cases reported.

Objectives: To describe the historical, clinical, laboratory, and scintigraphic features of adult cats with spontaneous hypothyroidism.

Animals: Seven adult cats referred for suspected hypothyroidism. Read More

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http://doi.wiley.com/10.1111/jvim.15239
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http://dx.doi.org/10.1111/jvim.15239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271337PMC
November 2018
4 Reads

Sirtuin‑1 protects hair follicle stem cells from TNFα-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway.

Life Sci 2018 Nov 4;212:213-224. Epub 2018 Oct 4.

Department of Dermatology and Venereology, Jiangsu Provincial People's Hospital, First Affiliated Hospital of Nanjing Medical University, 210029, China. Electronic address:

Objective: Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-mediated inflammatory stress in hair follicle stem cells (HFSCs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183062
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http://dx.doi.org/10.1016/j.lfs.2018.10.003DOI Listing
November 2018
1 Read

Study on Hair Distribution in Healthy Males for Hair Restoration Design.

J Craniofac Surg 2018 Nov;29(8):e785-e790

Department of Dermatology, Huashan Hospital affiliated of Fudan University.

Background: The incidence of hair loss among Chinese male has increased to 21.3 per hundred. Hair restoration has been an effective technique. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004765DOI Listing
November 2018
17 Reads

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

Nat Commun 2018 10 1;9(1):4015. Epub 2018 Oct 1.

Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). Read More

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http://dx.doi.org/10.1038/s41467-018-06307-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167318PMC
October 2018
1 Read

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance.

Authors:
Sho Kanzaki

Molecules 2018 Sep 30;23(10). Epub 2018 Sep 30.

Department of Otolaryngology Head and Neck Surgery, School of Medicine, KEIO University, Tokyo 160-8582, Japan.

The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies. Read More

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http://dx.doi.org/10.3390/molecules23102507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222543PMC
September 2018
2 Reads

Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles.

Int J Nanomedicine 2018 21;13:5625-5635. Epub 2018 Sep 21.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, People's Republic of China,

Background: As an immune-mediated skin disease, psoriasis encounters therapeutic challenges on topical drug development due to the unclear mechanism, and complicated morphological and physiological changes in the skin.

Methods: In this study, imiquimod-induced psoriatic mouse skin (IMQ-psoriatic skin) was chosen as the in vitro pathological model to explore the penetration behaviors of drugs and nanoparticles (NPs).

Results: Compared with normal skin, significantly higher penetration and skin accumulation were observed in IMQ-psoriatic skin for all the three model drugs. Read More

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http://dx.doi.org/10.2147/IJN.S170832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154705PMC
November 2018
8 Reads

Regulatory mechanisms of miR-96 and miR-184 abnormal expressions on otic vesicle development of zebrafish following exposure to β-diketone antibiotics.

Chemosphere 2019 Jan 19;214:228-238. Epub 2018 Sep 19.

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. Electronic address:

Chronic ototoxicity of β-diketone antibiotics (DKAs) to zebrafish (Danio rerio) was explored in detail by following abnormal expressions of two hearing-related miRNAs. Dose-dependent down-regulation of miR-96 and miR-184 was observed in otoliths during embryonic-larval development. Continuous DKA exposure to 120-hpf larva decreased sensitivity to acoustic stimulation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2018.09.118DOI Listing
January 2019
12 Reads

Dermoscopy findings of a one mm lentigo maligna.

Dermatol Online J 2018 Sep 15;24(7). Epub 2018 Sep 15.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota Department of Dermatology, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota Department of Medicine, University of Minnesota, Minneapolis, Minnesota Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota.

A 66-year-old man presented with a grayish 1mm macule on the left cheek. Dermatoscopic examination revealed annular-granular structures partially surrounding a single follicular ostium. Histopathologic examination demonstrated atypical, confluent single melanocytes at the basal layer with nesting, crowding, and upward migration descending along the hair follicle, consistent with the diagnosis of lentigo maligna (LM). Read More

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September 2018
4 Reads

Retrospective assessment of specific effects of exposure of workers to PCBs in Slovakia.

Ann Agric Environ Med 2018 Sep 9;25(3):421-427. Epub 2018 Apr 9.

1st Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.

Introduction And Objective: Polychlorinated biphenyls (PCBs) have been used commercially since 1929 as dielectric and insulating non-flammable substances, additives for paints, etc. In Slovakia, 60 chemical production workers highly exposed to PCBs (mainly to Delor 103) were studied with duration of exposure ranging from 3 months to 19 years.

Material And Methods: Clinical examinations of skin, skin histology and laboratory tests concerning lipid metabolism, iron metabolism and levels of copper provided comparisons with a control group of healthy individuals and/or the upper limits of normal values. Read More

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http://dx.doi.org/10.26444/aaem/86307DOI Listing
September 2018
1 Read

Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses.

FEBS Lett 2018 Nov 9;592(21):3633-3650. Epub 2018 Oct 9.

Presynaptogenesis and Intracellular Transport in Hair Cells Group, Institute for Auditory Neuroscience and InnerEarLab, Auditory Neuroscience Group, Max Planck Institute of Experimental Medicine, University Medical Center Göttingen, Germany.

The timely and reliable processing of auditory and vestibular information within the inner ear requires highly sophisticated sensory transduction pathways. On a cellular level, these demands are met by hair cells, which respond to sound waves - or alterations in body positioning - by releasing glutamate-filled synaptic vesicles (SVs) from their presynaptic active zones with unprecedented speed and exquisite temporal fidelity, thereby initiating the auditory and vestibular pathways. In order to achieve this, hair cells have developed anatomical and molecular specializations, such as the characteristic and name-giving 'synaptic ribbons' - presynaptically anchored dense bodies that tether SVs prior to release - as well as other unique or unconventional synaptic proteins. Read More

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http://dx.doi.org/10.1002/1873-3468.13258DOI Listing
November 2018
2 Reads

Beneficial effects of Gelsemium-based treatment against paclitaxel-induced painful symptoms.

Neurol Sci 2018 Dec 24;39(12):2183-2196. Epub 2018 Sep 24.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000, Strasbourg, France.

Chemotherapeutic drugs induce various side effects including painful peripheral neuropathy that represents a major concern. The widely used anticancer drug paclitaxel causes neurological side effects such as burning pain, allodynia, and hyperalgesia. Neuroprotective substances that may effectively counteract paclitaxel-induced neuropathic symptoms are needed. Read More

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http://dx.doi.org/10.1007/s10072-018-3575-zDOI Listing
December 2018
1 Read

Masquerades less known: Case report of benign hair follicle tumors.

Indian J Ophthalmol 2018 Oct;66(10):1506-1508

Department of Orbit and Oculoplasty, Aravind Eye Hospital and Post-graduate Institute of Ophthalmology, Pondicherry, India.

Benign eyelid tumors derived from hair follicles are rare and frequently misdiagnosed as basal-cell carcinoma when evaluation is based on clinical evidence alone. The discrepancy between the clinical aspect and the histological diagnosis can be as high as 30-40%, even for experienced clinicians. Unfortunately, this masquerade is not only clinical but also histological. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1288_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173044PMC
October 2018
3 Reads

Stem Cells and the Bird Cochlea-Where Is Everybody?

Cold Spring Harb Perspect Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94315.

In sharp contrast to the adult mammalian cochlea, which lacks regenerative ability, the mature avian cochlea, or basilar papilla (BP) is capable of complete recovery from hearing loss after damage. Avian sensory hair cell regeneration relies on rousing quiescent supporting cells to proliferate or transdifferentiate after hair cell death. Unlike mammalian cochlear supporting cells, which have clearly defined subtypes, avian BP supporting cells are deceptively indistinguishable and molecular markers have yet to be identified. Read More

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a033183DOI Listing
September 2018
9 Reads