16,688 results match your criteria Haemophilus Influenzae Infections


The seventh nationwide surveillance of six otorhinolaryngological infectious diseases and the antimicrobial susceptibility patterns of the isolated pathogens in Japan.

J Infect Chemother 2020 Jul 1. Epub 2020 Jul 1.

Otorhinolaryngological Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID), The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.

The Japanese Three Academic Societies Joint Antimicrobial Susceptibility Surveillance Committee conducted a nationwide surveillance on six otorhinolaryngological diseases and investigated the antimicrobial susceptibility patterns and isolation rates of the causative pathogens. The surveillance program was conducted in the otorhinolaryngological departments of 12 universities, and 36 affiliated hospitals and clinics. Patients with acute otitis media (children under six years old), chronic otitis media, acute nasal sinusitis, chronic nasal sinusitis, acute tonsillitis, and peritonsillar abscess (over 20 years old) between December 2015 and June 2017 were investigated. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.020DOI Listing

Recurrent invasive meningococcal infections - quantifying the risk, Germany, 2002 to 2018.

Euro Surveill 2020 Jun;25(25)

Institute for Hygiene and Microbiology, National Reference Laboratory for Meningococci and Haemophilus influenzae, University of Würzburg, Würzburg, Germany.

IntroductionInvasive meningococcal disease (IMD) is a rare condition with a high case fatality rate. While most patients suffer from one single episode in life, there is anecdotal evidence for recurrent infection.AimThe German National Reference Laboratory for Meningococci and (NRZMHi) analysed IMD cases from 2002 to 2018 to retrospectively quantify the risk of recurrent infection. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.1900565DOI Listing

Tetracycline resistance in Moraxella catarrhalis clinical strains isolated in Poland.

New Microbiol 2020 Jun 29;43(3). Epub 2020 Jun 29.

Medical University of Lublin, Department of Medical Microbiology, Chodźki 1, 20-093 Lublin, Poland.

Moraxella catarrhalis is considered an important, exclusively human respiratory tract pathogen which, along with Streptococcus pneumoniae and Haemophilus influenzae, is classified as one of the most frequent bacterial etiological factors causing upper respiratory tract infections. In this manuscript, we report the existence of five tetracycline-resistant M. catarrhalis strains with confirmed presence of tetracycline resistance tetB gene. Read More

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Presence of antibodies against Haemophilus influenzae serotype a in Alaska prior to and after the emergence of invasive infections.

J Infect Dis 2020 Jun 28. Epub 2020 Jun 28.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention.

Background: Haemophilus influenzae bacteria can cause asymptomatic carriage and invasive disease. H. influenzae serotype a (Hia) is an emerging cause of invasive disease in Alaska, with greatest burden occurring among rural Alaska Native (AN) children. Read More

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http://dx.doi.org/10.1093/infdis/jiaa369DOI Listing

The incidence of anaerobic bacteria in adult patients with chronic sinusitis: A prospective, single-centre microbiological study.

Eur J Microbiol Immunol (Bp) 2020 Jun 5. Epub 2020 Jun 5.

4 Department of Oto-Rhino-Laryngology and Head-, Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Introduction: Chronic sinusitis caused by anaerobes is a particular concern clinically, because many of the complications are associated with infections caused by these organisms. The aim of this study was to evaluate the incidence of anaerobic bacteria in chronic sinusitis in adults as a part of a prospective microbiological study.

Materials And Methods: Over a one-year period, aspirations of maxillary sinus secretions and/or ethmoid cavities were derived in n = 79 adult patients with chronic sinusitis by endoscopy in a tertiary-care teaching hospital in Hungary. Read More

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http://dx.doi.org/10.1556/1886.2020.00010DOI Listing

Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.

Clin Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Arctic Investigations Program, CDC, Anchorage, AK, USA.

Background: Haemophilus influenzae serotype a (Hia) can cause invasive disease similar to serotype b; no Hia vaccine is available. We describe the epidemiology of invasive Hia disease in the United States overall and specifically in Alaska during 2008-2017.

Methods: Active population- and laboratory-based surveillance for invasive Hia disease was conducted through Active Bacterial Core surveillance sites and from Alaska statewide invasive bacterial disease surveillance. Read More

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http://dx.doi.org/10.1093/cid/ciaa875DOI Listing

Haemophilus spp., an emerging multidrug-resistant sexually transmitted pathogen.

Med Mal Infect 2020 Jun 19. Epub 2020 Jun 19.

Centre Hospitalier Universitaire de Bordeaux, Service des Maladies Infectieuses et Tropicales, Hôpital Pellegrin, F-33000 Bordeaux, France; Univ. Bordeaux, USC EA 3671, Infections humaines à mycoplasmes et à chlamydiae, F-33000 Bordeaux, France; Centre Hospitalier de Bordeaux, Centre National de Référence des Infections Sexuellement Transmissibles bactériennes, F-33000 Bordeaux, France.

Objectives: To describe the characteristics of patients with a positive urethral sample for Haemophilus spp.

Material And Methods: We performed a retrospective study from January 2018 to July 2019 at the Bordeaux university hospital (France) of all urethral samples positive for Haemophilus spp.

Results: Haemophilus spp. Read More

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http://dx.doi.org/10.1016/j.medmal.2020.06.003DOI Listing

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of japanese society of chemotherapy, the japanese association for infectious diseases, and the japanese society for clinical microbiology in 2016: General view of the pathogens' antibacterial susceptibility.

J Infect Chemother 2020 Jun 19. Epub 2020 Jun 19.

Saiseikai Kumamoto Hospital, Kumamoto, Japan.

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2016. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between February 2016 and August 2016 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.006DOI Listing

Trends and health burden of hospitalized acute respiratory infections and impact of Haemophilus influenza immunization in a Tunisian university hospital: a twelve-year study.

Libyan J Med 2020 Dec;15(1):1783048

Faculty of Medicine of Monastir, University of Monastir , Monastir, Tunisia.

Background: We aimed to describe the episodes and trends of admissions for community-acquired Respiratory Infections (RI) over a 12-year period and to assess the impact of Haemophilus influenza type b (Hib) vaccine on RI admissions in children aged up to 3 years.

Methods: We conducted a twelve-year retrospective observational study on all community-acquired RI admitted to Fattouma Bourguiba Hospital in Monastir Governorate (Tunisia) from 1 January 2002 to 31 December 2013. RI cases were selected from the Regional Registry of Hospital Morbidity. Read More

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http://dx.doi.org/10.1080/19932820.2020.1783048DOI Listing
December 2020

Haemophilus influenzae serotype a (Hia) carriage in a small Alaska community after a cluster of invasive Hia disease, 2018.

Clin Infect Dis 2020 Jun 12. Epub 2020 Jun 12.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA.

Background: Between May and July 2018, four invasive Haemophilus influenzae serotype a (iHia) infections occurred in a remote Alaska community. We performed a public health response to prevent further illness and understand Hia carriage in the community.

Methods: We collected oropharyngeal (OP) samples community-wide from untreated individuals to evaluate baseline carriage. Read More

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http://dx.doi.org/10.1093/cid/ciaa750DOI Listing

Lascufloxacin hydrochloride to treat bacterial infection.

Drugs Today (Barc) 2020 Jun;56(6):365-376

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Lascufloxacin hydrochloride (AM-1977) is a novel 8-methoxy fluoroquinolone antibacterial agent with a unique pharmacophore at the 1st and 7th positions of the quinoline nucleus developed by Kyorin Pharmaceutical Co., Ltd. (Tokyo, Japan). Read More

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http://dx.doi.org/10.1358/dot.2020.56.6.3137167DOI Listing

Airway bacterial carriage and childhood respiratory health: A population-based prospective cohort study.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Airway bacterial carriage might play a role in respiratory disease. We hypothesize that nasal carriage with Staphylococcus aureus or nasopharyngeal carriage with Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae predisposes individuals to adverse respiratory health.

Objective: To examine the association of early-life airway bacterial carriage with respiratory tract infections and vice versa, and of early-life airway bacterial carriage with wheezing, lung function, and asthma in later childhood. Read More

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http://dx.doi.org/10.1111/pai.13310DOI Listing

Long term storage of fastidious bacteria (Neisseria spp. and Haemophilus spp.) with swab preservation at -80 °C.

J Microbiol Methods 2020 Jun 5;175:105969. Epub 2020 Jun 5.

Department of Microbiology, Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Study Group on Sexually Transmitted Infections (GEITS), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC), Spain; Department of Functional Biology, Microbiology Area, Faculty of Medicine, University of Oviedo, Spain; Ophthalmological Research Foundation, Fernández-Vega Ophthalmological Institute, Oviedo, Spain.

Preservation of strains is important to further studies and characterization; we have shown a technique of long-term preservation of Neisseria spp. and Haemophilus spp. by freezing cotton tip swabs impregnated with fastidious organisms at -80 °C without the addition of cryoprotectants. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.105969DOI Listing

Clinical diagnostic application of metagenomic next-generation sequencing in children with severe nonresponding pneumonia.

PLoS One 2020 4;15(6):e0232610. Epub 2020 Jun 4.

Department of Respiratory Diseases, Shenzhen Children's Hospital, Shenzhen, China.

Pneumonia is one of the most important causes of morbidity and mortality in children. Identification and characterization of pathogens that cause infections are crucial for accurate treatment and accelerated recovery. However, in most cases, the causative agent cannot be identified, which is partly due to the limited spectrum of pathogens covered by current diagnostics based on nucleic acid amplification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272011PMC

Bacterial Community Interactions During Chronic Respiratory Disease.

Front Cell Infect Microbiol 2020 14;10:213. Epub 2020 May 14.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States.

Chronic respiratory diseases including chronic rhinosinusitis, otitis media, asthma, cystic fibrosis, non-CF bronchiectasis, and chronic obstructive pulmonary disease are a major public health burden. Patients suffering from chronic respiratory disease are prone to persistent, debilitating respiratory infections due to the decreased ability to clear pathogens from the respiratory tract. Such infections often develop into chronic, life-long complications that are difficult to treat with antibiotics due to the formation of recalcitrant biofilms. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240048PMC

Co-infections in people with COVID-19: a systematic review and meta-analysis.

J Infect 2020 May 27. Epub 2020 May 27.

Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK. Electronic address:

Objectives: In previous influenza pandemics, bacterial co-infections have been a major cause of mortality. We aimed to evaluate the burden of co-infections in patients with COVID-19.

Methods: We systematically searched Embase, Medline, Cochrane Library, LILACS and CINAHL for eligible studies published from 1 January 2020 to 17 April 2020. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255350PMC

Etiology of Pediatric Meningitis in West Africa Using Molecular Methods in the Era of Conjugate Vaccines against Pneumococcus, Meningococcus, and Type b.

Am J Trop Med Hyg 2020 May 26. Epub 2020 May 26.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia.

Despite the implementation of effective conjugate vaccines against the three main bacterial pathogens that cause meningitis, , type b (Hib), and serogroup A, the burden of meningitis in West Africa remains high. The relative importance of other bacterial, viral, and parasitic pathogens in central nervous system infections is poorly characterized. Cerebrospinal fluid (CSF) specimens were collected from children younger than 5 years with suspected meningitis presenting at pediatric teaching hospitals across West Africa in five countries including Senegal, Ghana, Togo, Nigeria, and Niger. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0566DOI Listing
May 2020
2.699 Impact Factor

Molecular epidemiology of imipenem resistance in invasive Haemophilus influenzae infections in Germany in 2016.

J Antimicrob Chemother 2020 May 25. Epub 2020 May 25.

Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2/E1, 97080 Würzburg, Germany.

Background: The carbapenems imipenem and meropenem play an important role in the empirical anti-infective treatment of critically ill patients. Carbapenem resistance in Haemophilus influenzae (Hi) has rarely been reported.

Objectives: We provide prevalence data for resistance to carbapenems from laboratory surveillance of invasive Hi infections in Germany in 2016. Read More

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http://dx.doi.org/10.1093/jac/dkaa159DOI Listing

10-Valent pneumococcal non-typeable protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: study protocol for a randomised controlled trial.

BMJ Open 2020 May 24;10(5):e033511. Epub 2020 May 24.

Child Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

Introduction: and non-typeable (NTHi) are major otitis media pathogens that densely co-colonise the nasopharynx and infect the middle ear of Australian Aboriginal infants from very early in life. Our co-primary hypotheses are that at 18 months of age infants receiving 10-valent pneumococcal protein D conjugate vaccine (PHiD-CV10) compared with those receiving 13-valent pneumococcal conjugate vaccine (PCV13) as a booster at 12 months of age will have higher antibody levels to protein D and that infants receiving PCV13 will have higher antibody levels to PCV13-only serotypes 3, 6A and 19A.

Methods And Analyses: Our randomised controlled trial will enrol 270 Aboriginal children at 12 months of age to a booster dose of either PHiD-CV10 or PCV13. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252982PMC

The Negative Predictive Ability of Immature Neutrophils for Bacteremia in Children With Community-Acquired Infections.

Front Pediatr 2020 6;8:208. Epub 2020 May 6.

Post-graduation Program in Health Sciences, Federal University of Bahia School of Medicine, Salvador, Brazil.

Bacteremia is a serious condition. We aimed to assess the role of immature neutrophils in peripheral blood smears for prediction of bacteremia in children. In this cross-sectional study conducted in Salvador, Brazil, blood cultures collected from patients aged ≤18 years were identified. Read More

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http://dx.doi.org/10.3389/fped.2020.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218047PMC

Pathogen analysis of pertussis-like syndrome in children.

BMC Infect Dis 2020 May 19;20(1):353. Epub 2020 May 19.

Department of Respiration, Children's Hospital of Soochow University, No. 303 Jing De Road, Suzhou, 215003, China.

Background: The aim of the study was to identify the pathogens, in addition to bordetella pertussis (B. pertussis), which cause pertussis-like syndrome in children and to compare clinical presentation between those with B. pertussis and pertussis-like syndrome. Read More

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http://dx.doi.org/10.1186/s12879-020-05074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236299PMC

Co-infection with respiratory pathogens among COVID-2019 cases.

Virus Res 2020 08 11;285:198005. Epub 2020 May 11.

NHC Key laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China. Electronic address:

Accumulating evidence shows that microbial co-infection increases the risk of disease severity in humans. There have been few studies about SARS-CoV-2 co-infection with other pathogens. In this retrospective study, 257 laboratory-confirmed COVID-19 patients in Jiangsu Province were enrolled from January 22 to February 2, 2020. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213959PMC
August 2020
2.324 Impact Factor

Fatal pneumococcal septicemia in a girl with visceral heterotaxy and polysplenia: a case report.

Forensic Sci Med Pathol 2020 May 13. Epub 2020 May 13.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada.

We report an unusual case of a 15-month old previously healthy girl who died of pneumococcal septicemia in the background of visceral heterotaxy with polysplenia. Heterotaxy can also present with asplenia whereas polysplenia cases usually present with functional asplenia. Of particular note, this girl received the 13-valent pneumococcal conjugate vaccine as recommended by the Centers for Disease Control and Prevention in the routine pediatric immunization schedule used in the USA and Canada. Read More

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http://dx.doi.org/10.1007/s12024-020-00252-1DOI Listing

Discriminative potential of the VITEK® MS IVD regarding and .

J Clin Microbiol 2020 May 13. Epub 2020 May 13.

Institute for Hygiene and Microbiology, University of Wuerzburg, Wuerzburg, Germany

(Hi) can cause respiratory and invasive infections (1), whereas (Hh) is generally considered apathogenic (2) and is rarely associated with disease (3).…. Read More

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http://dx.doi.org/10.1128/JCM.00278-20DOI Listing

An up-to-date review on bio-resource therapeutics effective against bacterial species frequently associated with chronic sinusitis and tonsillitis.

Curr Med Chem 2020 May 4. Epub 2020 May 4.

Department of Plant Physiology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade. Serbia.

Infections of the upper respiratory tract include inflammations of the nose, sinuses (sinusitis), pharynx (tonsillitis, pharyngitis) and larynx (laryngitis) with bacteria or viruses as the main cause of these conditions. Due to their repetitive nature, chronic respiratory infections represent a global problem which is often a result of an improper treatment. If not treated adequately, these conditions may have serious consequences. Read More

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http://dx.doi.org/10.2174/0929867327666200505093143DOI Listing

Pulmonary alveolar proteinosis.

Respirology 2020 May 3. Epub 2020 May 3.

Department of Radiology, CHU Rennes, Univ Rennes, Rennes, France.

PAP is an ultra-rare disease in which surfactant components, that impair gas exchange, accumulate in the alveolae. There are three types of PAP. The most frequent form, primary PAP, includes autoimmune PAP which accounts for over 90% of all PAP, defined by the presence of circulating anti-GM-CSF antibodies. Read More

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http://dx.doi.org/10.1111/resp.13831DOI Listing

Epidemiology of bacteria and viruses in the respiratory tract of humans and domestic pigs.

APMIS 2020 Jun;128(6):451-462

Institute for Infection Medicine, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Bacteria and viruses were analysed in the upper respiratory tract of symptomatic pig farmers and their domestic pigs. Eighty six human nasal and 495 (50 pools) porcine snout swabs were collected in Schleswig-Holstein, Germany. Staphylococcus (S. Read More

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http://dx.doi.org/10.1111/apm.13046DOI Listing

Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65.

BMC Infect Dis 2020 May 1;20(1):319. Epub 2020 May 1.

Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People's Republic of China.

Background: Trichomoniasis resulting from Trichomonas vaginalis (T. vaginalis) has been considered as a commonly seen disease with the transmission way of sex. At present, the detection methods of T. Read More

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http://dx.doi.org/10.1186/s12879-020-05048-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195720PMC

Pathobionts in the Vaginal Microbiota: Individual Participant Data Meta-Analysis of Three Sequencing Studies.

Front Cell Infect Microbiol 2020 15;10:129. Epub 2020 Apr 15.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

Sequencing studies have shown that optimal vaginal microbiota (VMB) are lactobacilli-dominated and that anaerobes associated with bacterial vaginosis (BV-anaerobes) are commonly present. However, they overlooked a less prevalent but more pathogenic group of vaginal bacteria: the pathobionts that cause maternal and neonatal infections and pelvic inflammatory disease. We conducted an individual participant data meta-analysis of three VMB sequencing studies that included diverse groups of women in Rwanda, South Africa, and the Netherlands (2,044 samples from 1,163 women in total). Read More

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http://dx.doi.org/10.3389/fcimb.2020.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174631PMC
April 2020
2.620 Impact Factor

Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in Turkey: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

J Antimicrob Chemother 2020 Apr;75(Supplement_1):i88-i99

IHMA Europe Sàrl, Route de l'Ile-au-Bois 1A, 1870 Monthey/VS, Switzerland.

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates from community-acquired respiratory tract infections (CA-RTIs) collected in 2015-17 from Turkey.

Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results: A total of 179 S. Read More

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http://dx.doi.org/10.1093/jac/dkaa086DOI Listing

Results from the Survey of Antibiotic Resistance (SOAR) 2016-18 in Vietnam, Cambodia, Singapore and the Philippines: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

J Antimicrob Chemother 2020 Apr;75(Supplement_1):i19-i42

IHMA Europe Sàrl, Route de l'Ile-au-Bois 1A, 1870 Monthey/VS, Switzerland.

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates collected from community-acquired respiratory tract infections (CA-RTIs) in 2016-18 in four Asian countries.

Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results: In total, 260 S. Read More

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http://dx.doi.org/10.1093/jac/dkaa082DOI Listing

Results from the Survey of Antibiotic Resistance (SOAR) 2016-17 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

J Antimicrob Chemother 2020 Apr;75(Supplement_1):i100-i111

IHMA, Europe Sàrl, Route de l'Ile-au-Bois, 1A, 1870 Monthey/VS, Switzerland.

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates from community-acquired respiratory tract infections (CA-RTIs) collected in 2016-17 from Ukraine.

Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results: A total of 177 viable clinical isolates, including 78 S. Read More

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http://dx.doi.org/10.1093/jac/dkaa087DOI Listing

Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in Latin America (Argentina, Chile and Costa Rica): data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

J Antimicrob Chemother 2020 Apr;75(Supplement_1):i43-i59

IHMA Europe Sàrl, Route de l'Ile-au-Bois 1A, 1870 Monthey/VS, Switzerland.

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates from community-acquired respiratory tract infections (CA-RTIs) collected in 2015-17 from Argentina, Chile and Costa Rica.

Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results: A total of 170 S. Read More

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http://dx.doi.org/10.1093/jac/dkaa083DOI Listing

Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in the Middle East (Kuwait, Lebanon and Saudi Arabia): data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

J Antimicrob Chemother 2020 Apr;75(Supplement_1):i60-i75

IHMA Europe Sàrl, Route de l'Ile-au-Bois 1A, 1870 Monthey/VS, Switzerland.

Objectives: To determine antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae isolates from community-acquired respiratory tract infections (CA-RTIs) collected in 2015-17 from Kuwait, Lebanon and Saudi Arabia.

Methods: MICs were determined by CLSI broth microdilution and susceptibility was assessed using CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints.

Results: A total of 139 S. Read More

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http://dx.doi.org/10.1093/jac/dkaa084DOI Listing

Co-detection of bocavirus and bacteria in a respiratory specimen from a pregnant woman using multiplex real time PCR; a pathogenic role, or a bystander?

Iran J Microbiol 2020 Feb;12(1):70-72

Clinical Virology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

A pregnant woman presented by cough and dyspenia. Employing a respiratory multiplex real-time PCR, Human bocavirus (HBoV), Haemophilus influenza and were positive at cycle thresholds (CTs) of 21, 35 and 33.5, respectively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163035PMC
February 2020

Evaluation of the BioFire FilmArray Pneumonia Panel for Detection of Viral and Bacterial Pathogens in Lower Respiratory Tract Specimens in the Setting of a Tertiary Care Academic Medical Center.

J Clin Microbiol 2020 Jun 24;58(7). Epub 2020 Jun 24.

Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA

Our objective was to evaluate the diagnostic yield and accuracy of the BioFire FilmArray pneumonia panel (BFPP) for identification of pathogens in lower respiratory tract specimens ( = 200) from emergency department (ED) and intensive care unit (ICU) patients at a tertiary care academic medical center. Specimens were collected between January and November 2018, from patients ≥18 years of age, and culture was performed as part of standard-of-care testing. The BFPP identified a viral or bacterial target in 117/200 (58. Read More

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http://dx.doi.org/10.1128/JCM.00343-20DOI Listing

The novel E. coli cell division protein, YtfB, plays a role in eukaryotic cell adhesion.

Sci Rep 2020 Apr 21;10(1):6745. Epub 2020 Apr 21.

ithree institute, University of Technology Sydney, 15 Broadway, Ultimo, NSW, 2007, Sydney, Australia.

Characterisation of protein function based solely on homology searches may overlook functions under specific environmental conditions, or the possibility of a protein having multiple roles. In this study we investigated the role of YtfB, a protein originally identified in a genome-wide screen to cause inhibition of cell division, and has demonstrated to localise to the Escherichia coli division site with some degree of glycan specificity. Interestingly, YtfB also shows homology to the virulence factor OapA from Haemophilus influenzae, which is important for adherence to epithelial cells, indicating the potential of additional function(s) for YtfB. Read More

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http://dx.doi.org/10.1038/s41598-020-63729-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174318PMC

Unraveling Haemophilus influenzae virulence mechanisms enable discovery of new targets for antimicrobials and vaccines.

Curr Opin Infect Dis 2020 Jun;33(3):231-237

Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences.

Purpose Of Review: The human upper respiratory tract is colonized with a variety of bacterial microorganisms including Haemophilus influenzae. The species H. influenzae consists of typeable and nontypeable H. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000645DOI Listing

Associations between respiratory infections and bacterial microbiome in student dormitories in Northern China.

Indoor Air 2020 Apr 18. Epub 2020 Apr 18.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, PR China.

Recent studies reveal that the microbial diversity and composition in the respiratory tract are related to the susceptibility, development, and progression of respiratory infections. Indoor microorganisms can transmit into the respiratory tract through breathing, but their role in infections is unclear. Here, we present the first association study between the indoor microbiome and respiratory infections. Read More

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http://dx.doi.org/10.1111/ina.12677DOI Listing

Immunization with a Biofilm-Disrupting Nontypeable Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media.

mSphere 2020 04 15;5(2). Epub 2020 Apr 15.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

The use of broad-spectrum antibiotics to treat diseases, such as the highly prevalent pediatric disease otitis media (OM), contributes significantly to the worldwide emergence of multiple-antibiotic-resistant microbes, and gut dysbiosis with diarrhea is a common adverse sequela. Moreover, for many diseases, like OM, biofilms contribute significantly to chronicity and recurrence, yet biofilm-resident bacteria are characteristically highly resistant to antibiotics. The most cost-effective way to both prevent and resolve diseases like OM, as well as begin to address the problem of growing antibiotic resistance, would be via the development of novel approaches to eradicate bacterial biofilms. Read More

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http://dx.doi.org/10.1128/mSphere.00296-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160684PMC

Molecular Epidemiology and Antimicrobial Resistance of in Adult Patients in Shanghai, China.

Front Public Health 2020 27;8:95. Epub 2020 Mar 27.

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The serotype and antimicrobial resistance of in adult patients have changed due to the application of antimicrobials and type b (Hib) vaccine worldwide. However, the epidemiologic characteristics of in Shanghai are still unavailable. To determine the serotype distribution, antimicrobial resistance and multilocus sequence type (MLST) of in adult patients in Shanghai. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135888PMC

Case Report: Invasive Non Type b Haemophilus influenzae in Immunocompromised Children.

Am J Case Rep 2020 Apr 11;21:e920853. Epub 2020 Apr 11.

Department of Pediatrics, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.

BACKGROUND Implementation of the Haemophilus influenzae type b (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but increase in nontypeable strain infections. CASE REPORT We had 3 cases of invasive non type Hemophilus influenzae (NTBHI) in immunocompromised children. The first was a fully vaccinated 2-year-old male with a history of pseudomonas sepsis who presented with 1 day of lethargy, fever, vomiting, and diarrhea. Read More

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http://dx.doi.org/10.12659/AJCR.920853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172003PMC

Trends in Antibiotic Resistance Among Ocular Microorganisms in the United States From 2009 to 2018.

JAMA Ophthalmol 2020 Apr 9. Epub 2020 Apr 9.

Pharmaceutical Medical Affairs, Bausch + Lomb, Rochester, New York.

Importance: Antibiotic resistance in ocular infections can affect treatment outcomes. Surveillance data on evolving antibacterial susceptibility patterns inform the treatment of such infections.

Objective: To assess overall antibiotic resistance profiles and trends among bacterial isolates from ocular sources collected during 10 years. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2020.0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146550PMC

[Antimicrobial activity of dioxidine and a dioxidin-containing preparation «Nosolin-Ultra, nasal drops».]

Klin Lab Diagn 2020 ;65(4):244-250

CJSC «FIRN-M», Obolensk, Moscow region, Russia.

The study is devoted to the study of the antimicrobial activity of the antioxidant dioxidin and the complex dioxin-containing preparation Nosolin-ultra, nasal drops against planktonic and biofilm cultures of pathogens of ENT infections, the dynamics of the formation of microbial resistance to dioxidine. 11 reference strains and 9 clinical strains of microorganisms were used in the study: Streptococcus spp., Staphylococcus spp. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-4-244-250DOI Listing
January 2020

Internal exposure to perfluoroalkyl substances (PFASs) and biological markers in 101 healthy 1-year-old children: associations between levels of perfluorooctanoic acid (PFOA) and vaccine response.

Arch Toxicol 2020 Jun 29;94(6):2131-2147. Epub 2020 Mar 29.

Department Food Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.

Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the lead compounds. They are immunotoxic in experimental animals, and epidemiological studies provided evidence of a diminished production of vaccine antibodies in young children. Read More

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http://dx.doi.org/10.1007/s00204-020-02715-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303054PMC

In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of .

Pathogens 2020 Mar 25;9(4). Epub 2020 Mar 25.

School of Health Sciences, University of Tasmania, Newnham Drive, Launceston, TAS 7248, Australia.

Nontypeable (NTHi) is a leading causative organism of opportunistic respiratory tract infections. However, there are currently no effective vaccination strategies, and existing treatments are compromised by antibiotic resistance. We previously characterized (Hh) strains capable of producing haemophilin (HPL), a heme-binding protein that restricts NTHi growth by limiting its access to an essential growth factor, heme. Read More

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http://dx.doi.org/10.3390/pathogens9040243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238096PMC

Draft Genome Sequence of a Haemophilus parainfluenzae Strain Isolated from a Patient with Chronic Obstructive Pulmonary Disease.

Microbiol Resour Announc 2020 Mar 26;9(13). Epub 2020 Mar 26.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

is considered part of the normal oropharyngeal flora but is known to occasionally cause infections. It is closely related to Here, we report the genome sequence of COPD-014-E1 O, which was cultured from the sputum of a patient with chronic obstructive pulmonary disease. Read More

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http://dx.doi.org/10.1128/MRA.00079-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098898PMC

Immune modulatory capacity of probiotic lactic acid bacteria and applications in vaccine development.

Benef Microbes 2020 May 27;11(3):213-226. Epub 2020 Mar 27.

Razi Vaccine and Serum Research Institute (RVSRI), Agricultural Research, Education and Extension Organization (AREEO), P.O. Box 31975/148, Karaj, Iran.

Vaccination is one of the most important prevention tools providing protection against infectious diseases especially in children below the age of five. According to estimates, more than 5 million lives are saved annually by the implementation of six standard vaccines, including diphtheria, hepatitis B, type b, polio, tetanus and yellow fever. Despite these efforts, we are faced with challenges in developing countries where increasing population and increasing disease burden and difficulties in vaccine coverage and delivery cause significant morbidity and mortality. Read More

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http://dx.doi.org/10.3920/BM2019.0121DOI Listing

type b invasive infections in children hospitalized between 2000 and 2017 in a Pediatric Reference Hospital (PRH).

Heliyon 2020 Mar 19;6(3):e03483. Epub 2020 Mar 19.

Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell, Uruguay.

Background: Uruguay incorporated the conjugate vaccine against b (Hib) in 1994. In 2008, the vaccine was changed from one with natural conjugated capsular polysaccharide to one with a synthetic polysaccharide component. We describe the frequency and characteristics of invasive Hib infections in children hospitalized in a Pediatric Reference Hospital (PRH) between January 1st, 2000 and December 31st, 2017. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083785PMC