16,186 results match your criteria Haemophilus Influenzae Infections


Nasopharyngeal Microbiota in Children With Invasive Pneumococcal Disease: Identification of Bacteria With Potential Disease-Promoting and Protective Effects.

Front Microbiol 2019 28;10:11. Epub 2019 Jan 28.

Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain.

The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or protective factor in the development of invasive disease caused by . We analyzed the nasopharyngeal microbiota of children with invasive pneumococcal disease (IPD) and that of healthy controls matched by age, sex, and seasonality from Catalonia, Spain. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360994PMC
January 2019
1 Read

Incidence of invasive Haemophilus influenzae infections in children with sickle cell disease.

Pediatr Blood Cancer 2019 Feb 5:e27642. Epub 2019 Feb 5.

Department of Pediatrics, Division of Infectious Diseases, Emory University, Atlanta, Georgia.

Background: Children with sickle cell disease (SCD) are at increased risk for invasive infection with encapsulated bacteria. Antibiotic prophylaxis and immunizations against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) have decreased the overall incidence of invasive infections and have shifted distribution of serotypes causing disease toward those not covered by immunizations. We sought to determine the current incidence of invasive H. Read More

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http://dx.doi.org/10.1002/pbc.27642DOI Listing
February 2019

New insights into culture negative endophthalmitis by unbiased next generation sequencing.

Sci Rep 2019 Jan 29;9(1):844. Epub 2019 Jan 29.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.

The proof-of-concept, study to investigate the presence of microorganisms in presumed infectious endophthalmitis using Next generation sequencing (NGS) was carried out in vitreous biopsies from 34 patients with endophthalmitis, and thirty patients undergoing surgery for non-infectious retinal disorders as controls. Following DNA extraction using the Qiagen mini kit and PCR amplification of the V3-V4 regions of the bacterial 16S rRNA and ITS 2 region of fungus, they samples were sequenced on an Illumina HiSeq 2500 Machine. Paired reads were curated, taxonomically labeled, and filtered. Read More

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http://www.nature.com/articles/s41598-018-37502-w
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http://dx.doi.org/10.1038/s41598-018-37502-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351655PMC
January 2019
3 Reads

Panax Notoginseng Extract Possesses Significant Antibacterial Activity against Pathogenic Streptococci.

Pharmacology 2019 Jan 28;103(5-6):221-227. Epub 2019 Jan 28.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo,

Background: In traditional Chinese medicine, Panax notoginseng is used to treat inflammation and bleeding but has not been shown to affect bacterial pathogens.

Objectives: Our aim was to assess the antibacterial potential of Panax notoginseng extract (PNE) against bacterial pathogens.

Methods: PNE was dissolved in autoclaved distilled water. Read More

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http://dx.doi.org/10.1159/000496830DOI Listing
January 2019

Bacterial and Viral Identification Rate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea.

Yonsei Med J 2019 Feb;60(2):216-222

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

Purpose: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in Western countries. We investigated bacterial and viral identification rates in AECOPD in Korea. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.2.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342712PMC
February 2019
1 Read

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Microbiol Resour Announc 2019 Jan 10;8(2). Epub 2019 Jan 10.

Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.

Nontypeable Haemophilus influenzae (NTHi) is a major bacterial pathogen that causes multiple infections. We report high-depth-coverage RNA-Seq data from three NTHi strains, each of which encodes a different phase-variable methyltransferase. Major gene expression differences occur, commensurate with phase variation, and data will serve as an important resource for future studies. Read More

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http://dx.doi.org/10.1128/MRA.01500-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328670PMC
January 2019

Respiratory Pathogens in Infants Diagnosed with Acute Lower Respiratory Tract Infection in a Tertiary Care Hospital of Western India Using Multiplex Real Time PCR.

Indian J Pediatr 2019 Jan 14. Epub 2019 Jan 14.

Department of Pediatrics, T.N. Medical College & B.Y.L. Nair Hospital, Mumbai, India.

Objective: To determine the frequency of respiratory pathogens in infants diagnosed with acute lower respiratory tract infections.

Methods: A prospective cross-sectional observational study was conducted in infants hospitalized with a diagnosis of acute lower respiratory tract infection (ALRTI), in a tertiary care hospital in a metropolitan city of Western India. Nasopharyngeal swabs were analyzed by multiplex real time polymerase chain reaction, for 18 viruses and 3 bacteria (H. Read More

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http://dx.doi.org/10.1007/s12098-018-2840-8DOI Listing
January 2019
1 Read

Respiratory Bacterial Culture Sampling in Expectorating and Non-expectorating Patients With Cystic Fibrosis.

Front Pediatr 2018 18;6:403. Epub 2018 Dec 18.

Department of Pediatrics, Pediatric Pulmonology and Pediatric Infectious Diseases, Cystic Fibrosis Clinic, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Different respiratory sampling methods exist to identify lower airway pathogens in patients with cystic fibrosis (CF), of which bronchoalveolar lavage (BAL), and expectorated sputum are considered the "gold standard." Because BAL cannot be repeated limitless, the diagnosis of lower respiratory tract infections in non-expectorating patients is challenging. Other sampling techniques are nasal swab, cough swab, and induced sputum. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00403/
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http://dx.doi.org/10.3389/fped.2018.00403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305441PMC
December 2018
5 Reads

EF-Tu From Non-typeable Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies.

Front Immunol 2018 18;9:2910. Epub 2018 Dec 18.

Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.

Non-typeable (NTHi), a commensal organism in pre-school children, is an opportunistic pathogen causing respiratory tract infections including acute otitis media. Adults suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized by NTHi. Previous research has suggested that, in some bacterial species, the intracellular elongation factor thermo-unstable (EF-Tu) can moonlight as a surface protein upon host encounter. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02910
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http://dx.doi.org/10.3389/fimmu.2018.02910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305414PMC
December 2018
9 Reads

HRV16 Impairs Macrophages Cytokine Response to a Secondary Bacterial Trigger.

Front Immunol 2018 18;9:2908. Epub 2018 Dec 18.

Institut Cochin, Inserm U1016, Paris, France.

Human rhinovirus is frequently seen as an upper respiratory tract infection but growing evidence proves the virus can cause lower respiratory tract infections in patients with chronic inflammatory lung diseases including chronic obstructive pulmonary disease (COPD). In addition to airway epithelial cells, macrophages are crucial for regulating inflammatory responses to viral infections. However, the response of macrophages to HRV has not been analyzed in detail. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305396PMC
December 2018
1 Read

Antimicrobial Activity of Omadacycline Tested against Clinical Bacterial Isolates from Hospitals in China (including Hong Kong) and Taiwan: Results from the SENTRY Antimicrobial Surveillance Program (2013-2016).

Antimicrob Agents Chemother 2019 Jan 7. Epub 2019 Jan 7.

JMI Laboratories, North Liberty, IA 52317, USA.

Omadacycline is a derivative of minocycline and the first agent of the aminomethylcycline class. A total of 3,282 organisms (one per patient) were consecutively collected from patients hospitalized in China (including Hong Kong) and Taiwan. Susceptibility testing was performed by broth microdilution methods in a central laboratory (JMI Laboratories). Read More

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http://dx.doi.org/10.1128/AAC.02262-18DOI Listing
January 2019
3 Reads

Surveillance on susceptibility of strains isolated from pediatric infections.

J Infect Chemother 2019 Mar 29;25(3):163-169. Epub 2018 Dec 29.

The Promotion Committee for Proper Use of Pediatric Quinolones of Japanese Society of Chemotherapy, The Japanese Association for Infectious Diseases and the Japanese Society for Pediatric Infectious Diseases, Tokyo, Japan.

During the period from January to December 2015, 104 Streptococcus pneumoniae strains, 129 Haemophilus influenzae strains and 54 Moraxella catarrhalis strains isolated from clinical specimens of pediatric infections in the national 16 institutions, studied susceptibilities of total 28 antibiotics, the capsular serotype for S. pneumoniae, the capsular b type and β-lactamase production capability for H. influenzae, and the β-lactamase production capability for M. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.11.004DOI Listing
March 2019
2 Reads

Pharmacokinetic/pharmacodynamic (PK/PD) evaluation of tulathromycin against Haemophilus parasuis in an experimental neutropenic guinea pig model.

PLoS One 2018 31;13(12):e0209177. Epub 2018 Dec 31.

College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, China.

The objective of the study was to develop an ex-vivo PK/PD model of intramuscular (IM) administration of tulathromycin and to test its efficacy against Haemophilus parasuis (H. parasuis) infection in intraperitoneal-inoculated neutropenic guinea pigs. The pharmacokinetics (PKs) of tulathromycin at doses of 1 and 10 mg/kg in H. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209177PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312216PMC
December 2018
1 Read

Inherited Classical and Alternative Pathway Complement Deficiencies in Children: A Single Center Experience.

Iran J Immunol 2018 Dec;15(4):309-320

Dr BehcetUz Children's Hospital, Pediatric Allergy and Immunology, Izmir, Istanbul, Turkey.

Background: Primary complement deficiencies are rare diseases.

Objective: To retrospectively evaluate the clinical and laboratory findings and complications of patients to increase awareness of pediatricians about complement deficiencies, which are rarely encountered.

Methods: In this study, the clinical and immunological characteristics of 21 patients who consulted the Immunology Department of our hospital between 2003 and 2017 and were diagnosed with classical or alternative pathway complement deficiency were obtained from the file records. Read More

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http://dx.doi.org/10.22034/IJI.2018.39400DOI Listing
December 2018
2 Reads

Breech at the Border: An Atypical Case of Invasive in a Patient on a Novel Immunotherapeutic.

Open Forum Infect Dis 2018 Jul 26;5(7):ofy146. Epub 2018 Jun 26.

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

e rarely causes pyogenic infections in the female genital tract, and even less commonly does this lead to systemic infections. Novel monoclonal antibody therapies targeting interleukin-17 may impair mucosal immunity, but increased risk for e infections has not been documented. Here, we describe a case of e bacteremia associated with pyosalpinx and hypothesize that immunomodulatory treatment for psoriasis predisposed our patient to this infection. Read More

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http://dx.doi.org/10.1093/ofid/ofy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299461PMC
July 2018
3 Reads

Bacterial meningitis in Niger: an analysis of national surveillance data, 2003-2015.

Pan Afr Med J 2018 30;30:235. Epub 2018 Jul 30.

Centre de Recherche Médicale et Sanitaire (CERMES), BP 10887, 634 Bd de la Nation, YNo34 Niamey, Niger.

Introduction: Bacterial meningitis (BM) is one of the most severe infectious disease in Niger republic. To best describe the trends of BM disease, meningitis surveillance data from the Centre de Recherche Medicale et Sanitaire (CERMES) and the Direction of Surveillance and Response to Epidemics (DSRE) were reviewed and analyzed.

Methods: Data on number of notified cases of BM and on pathogens were analyzed during 2003-2015. Read More

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http://www.panafrican-med-journal.com/content/article/30/235
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http://dx.doi.org/10.11604/pamj.2018.30.235.15937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295294PMC
January 2019
10 Reads

Spectrum of bactericidal action of amylmetacresol/2,4-dichlorobenzyl alcohol lozenges against oropharyngeal organisms implicated in pharyngitis.

Int J Gen Med 2018 28;11:451-456. Epub 2018 Nov 28.

Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK,

Purpose: Pharyngitis is commonly caused by a self-limiting upper respiratory tract infection (URTI) and symptoms typically include sore throat. Antibiotics are often inappropriately used for the treatment of pharyngitis, which can contribute to antimicrobial resistance, therefore non-antibiotic treatments which have broad antiseptic effects may be more appropriate. Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) are present in some antiseptic lozenges and have established benefits in providing symptomatic relief and some in vitro antiviral action. Read More

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http://dx.doi.org/10.2147/IJGM.S184406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276617PMC
November 2018
15 Reads

Spotlight on inhaled ciprofloxacin and its potential in the treatment of non-cystic fibrosis bronchiectasis.

Drug Des Devel Ther 2018 27;12:4059-4066. Epub 2018 Nov 27.

Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece,

Non-cystic fibrosis bronchiectasis (NCFB) is a severe chronic illness characterized by irreversible dilation of airways and thickening of bronchial walls, chronic inflammation, repeated infections, and progressive obstruction of the airways. In contrast to cystic fibrosis bronchiectasis (CFB), which is a well-defined genetic disorder, NCFB is a heterogeneous disease caused by many different medical entities. Inhaled antibiotics are effective for patients with CFB, but their efficacy in NCFB has not been proven. Read More

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http://dx.doi.org/10.2147/DDDT.S168014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267620PMC
November 2018
1 Read

Development of a lateral flow test for the rapid detection of Avibacterium paragallinarum in chickens suspected of having infectious coryza.

BMC Vet Res 2018 Dec 19;14(1):411. Epub 2018 Dec 19.

Laboratorios de Investigación y Desarrollo, FARVET SAC, Carretera Panamericana Sur Nº766 Km 198.5, Chincha Alta, 11702, Ica, Peru.

Background: Infectious coryza (IC) is an acute respiratory disease of growing chickens and layers caused by Avibacterium paragallinarum. The development of tools that allow rapid pathogen detection is necessary in order to avoid disease dissemination and economic losses in poultry. An Av. Read More

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http://dx.doi.org/10.1186/s12917-018-1729-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300026PMC
December 2018
1 Read

Anti-EF-Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen Haemophilus influenzae.

Eur J Immunol 2018 Dec 19. Epub 2018 Dec 19.

Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.

Non-typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and occasionally suffer from exacerbations by the bacterium leading to increased morbidity. Elongation-factor thermo unstable (EF-Tu), a protein critical for bacterial protein synthesis, has been found to moonlight on the surface of several bacteria. Read More

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http://dx.doi.org/10.1002/eji.201847871DOI Listing
December 2018
1 Read

Feasibility of shotgun metagenomics to assess microbial ecology of pediatric tracheostomy tubes.

Laryngoscope 2019 Feb 22;129(2):317-323. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Cincinnati, OH, U.S.A.

Objective: Biofilm formation on medical devices such as tracheostomy tubes (TTs) is a serious problem. The clinical impact of biofilms on the airway is still unclear. Biofilms may play a role in granulation tissue development, recurrent airway infections, and failure of laryngotracheal reconstructions. Read More

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http://dx.doi.org/10.1002/lary.27356DOI Listing
February 2019
2 Reads

Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media.

R Soc Open Sci 2018 Nov 14;5(11):180810. Epub 2018 Nov 14.

Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Otitis media (OM) is a common polymicrobial infection of the middle ear in children under the age of 15 years. A widely used experimental strategy to analyse roles of specific phenotypes of bacterial pathogens of OM is to study changes in co-infection kinetics of bacterial populations in animal models when a wild-type bacterial strain is replaced by a specific isogenic mutant strain in the co-inoculating mixtures. As relationships between the OM bacterial pathogens within the host are regulated by many interlinked processes, connecting the changes in the co-infection kinetics to a bacterial phenotype can be challenging. Read More

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http://rsos.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsos.180810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281918PMC
November 2018
5 Reads

Etiology and epidemiology of community-acquired pneumonia in adults requiring hospital admission: A prospective study in rural Central Philippines.

Int J Infect Dis 2018 Dec 11;80:46-53. Epub 2018 Dec 11.

Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan; Collaborating Research Center for Emerging and Reemerging Infectious Diseases, Filinvest Corporate City, Alabang, Muntinlupa City, Metro Manila, Philippines.

Background: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality among adults worldwide. However, the distribution of the etiology of CAP varies from one country to another, with limited data from rural areas.

Methods: A prospective hospital-based study on adult CAP was conducted in Leyte, Central Philippines from May 2010 to May 2012. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.12.005DOI Listing
December 2018
3 Reads
2.330 Impact Factor

Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm.

MBio 2018 12 11;9(6). Epub 2018 Dec 11.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

Otitis media (OM) is often polymicrobial, with nontypeable (NTHI) and (Mcat) frequently cocultured from clinical specimens. Bacterial biofilms in the middle ear contribute to the chronicity and recurrence of OM; therefore, strategies to disrupt biofilms are needed. We have focused our vaccine development efforts on the majority subunit of NTHI type IV pili, PilA. Read More

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http://dx.doi.org/10.1128/mBio.02423-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299487PMC
December 2018
1 Read

Molecular serotyping of isolated from diseased pigs and the relationship between serovars and pathological patterns in Taiwan.

PeerJ 2018 29;6:e6017. Epub 2018 Nov 29.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.

Background: is the etiological agent of Glässer's disease, and causes severe economic losses in the swine industry. Serovar classification is intended as an indicator of virulence and pathotype and is also crucial for vaccination programs and vaccine development. According to a polysaccharide biosynthesis locus analysis, isolates could be classified by a molecular serotyping assay except serovars 5 and 12 detected by the same primer pair. Read More

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http://dx.doi.org/10.7717/peerj.6017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275120PMC
November 2018
2 Reads

Cefixime-associated acute generalized exanthematous pustulosis: Rare cases in India.

Indian J Pharmacol 2018 Jul-Aug;50(4):204-207

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Cefixime is a widely used third-generation cephalosporin schedule H1 drug, which is prescribed for the treatment of otitis media, respiratory tract infections, and uncomplicated urinary tract infections and is effective against infections caused by and species in India. The National Coordination Centre (NCC)-Pharmacovigilance Programme of India (PvPI), Indian Pharmacopoeia Commission (IPC), has received rare individual case safety reports (ICSRs) for acute generalized exanthematous pustulosis (AGEP) associated with the use of cefixime.

Materials And Methods: IPC, NCC-PvPI also acts as a national collaborating center for pharmacovigilance activities under the aegis of Ministry of Health and Family Welfare, Government of India; moreover, it is a member country in global pharmacovigilance system, World Health Organization-Uppsala Monitoring Centre, Sweden. Read More

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http://dx.doi.org/10.4103/ijp.IJP_673_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234709PMC
December 2018
1 Read
0.679 Impact Factor

Protection Against Invasive Infections in Children Caused by Encapsulated Bacteria.

Front Immunol 2018 20;9:2674. Epub 2018 Nov 20.

Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

The encapsulated bacteria , and (Group B Streptococcus) have been responsible for the majority of severe infections in children for decades, specifically bacteremia and meningitis. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines. Protection against these bacteria is largely mediated via polysaccharide-specific antibody and complement, although the contribution of these and other components, and the precise mechanisms, vary between species and include opsonophagocytosis and complement-dependent bacteriolysis. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02674
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http://dx.doi.org/10.3389/fimmu.2018.02674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255856PMC
November 2018
7 Reads

The Microbiology of Complicated Acute Sinusitis among Pediatric Patients: A Case Series.

Otolaryngol Head Neck Surg 2018 Nov 27:194599818815109. Epub 2018 Nov 27.

3 Division of Otolaryngology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: The microbiology of pediatric complicated acute rhinosinusitis (ARS) has evolved, and our current understanding of pathogenic organisms is limited. The objectives of this study are to describe the incidence of pathogens causing complicated ARS requiring surgical intervention at our institution over a 10-year period as well as their associated treatment outcomes.

Study Design: Retrospective cohort study. Read More

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http://journals.sagepub.com/doi/10.1177/0194599818815109
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http://dx.doi.org/10.1177/0194599818815109DOI Listing
November 2018
7 Reads

The prevalence of bacteriospermia in infertile men and association with semen quality in Southwestern Iran.

Infect Disord Drug Targets 2018 Nov 23. Epub 2018 Nov 23.

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz. Iran.

Introduction: Infertility considered as a social and public health issue and estimated that the most of these infertile couple are residents of developing countries. Infectious diseases including the history of sexually transmitted infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Read More

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http://dx.doi.org/10.2174/1871526519666181123182116DOI Listing
November 2018
10 Reads

Microbial virulence, molecular epidemiology and pathogenic factors of fluoroquinolone-resistant Haemophilus influenzae infections in Guangzhou, China.

Ann Clin Microbiol Antimicrob 2018 Nov 23;17(1):41. Epub 2018 Nov 23.

Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD, 21201, USA.

Background: Fluoroquinolone-resistant Haemophilus influenzae (FRHI) has been reported worldwide but remain unclear in China.

Methods: A total of 402 H. influenzae isolates collected from 2016 to 2017 were included. Read More

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http://dx.doi.org/10.1186/s12941-018-0290-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251178PMC
November 2018
13 Reads

Differential distribution of IgA-protease genotypes in mucosal and invasive isolates of Haemophilus influenzae in Sweden.

BMC Infect Dis 2018 Nov 22;18(1):592. Epub 2018 Nov 22.

Riesbeck Lab, Clinical Microbiology, Department of Translational Medicine, Lund University, Jan Waldenströms gata 59, SE20502, Malmö, Sweden.

Background: Several different IgA-proteases exist in Haemophilus influenzae. The variants have been suggested to play differential roles in pathogenesis, but there is limited information on their distribution in clinical isolates. The objective of this study was to investigate the distribution of IgA-protease genotypes in H. Read More

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http://dx.doi.org/10.1186/s12879-018-3464-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249890PMC
November 2018
2 Reads

Epidemiology of severe acute respiratory infections from hospital-based surveillance in Madagascar, November 2010 to July 2013.

PLoS One 2018 21;13(11):e0205124. Epub 2018 Nov 21.

National Influenza Centre, Virology Unit, Pasteur Institute of Madagascar, Antananarivo, Madagascar.

Background: Few comprehensive data exist regarding the epidemiology of severe acute respiratory infections (SARI) in low income countries. This study aimed at identifying etiologies and describing clinical features of SARI-associated hospitalization in Madagascar.

Methods: It is a prospective surveillance of SARI in 2 hospitals for 3 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205124PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248916PMC
November 2018
12 Reads

[Non-type b Haemophilus influenzae: a rare cause of meningitis in an infant with a guarded prognosis].

Pan Afr Med J 2018 22;30:164. Epub 2018 Jun 22.

Service de Microbiologie, CHU Mohammed VI, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.

Non-Type b Haemophilus is a rare cause of invasive secondary localization in young children. We here report the case of a child aged 11 months old who had Meningitis due to Non-Type b Haemophilus, a gram -negative bacilli of polymorphous appearance still exceptionally described in the literature, whose origin was undetermined and whose evolution was fatal. Clinicians and microbiologists should suspect the presence of these infrequent serotypes, especially on a particular case. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.164.15371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235511PMC
December 2018
3 Reads

The Interplay Between Immune Response and Bacterial Infection in COPD: Focus Upon Non-typeable .

Front Immunol 2018 5;9:2530. Epub 2018 Nov 5.

Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.

Chronic obstructive pulmonary disease (COPD) is a debilitating respiratory disease and one of the leading causes of morbidity and mortality worldwide. It is characterized by persistent respiratory symptoms and airflow limitation due to abnormalities in the lower airway following consistent exposure to noxious particles or gases. Acute exacerbations of COPD (AECOPD) are characterized by increased cough, purulent sputum production, and dyspnea. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230626PMC
November 2018

Detection of beta-lactamase-negative ampicillin resistance in Haemophilus influenzae in Belgium.

Diagn Microbiol Infect Dis 2019 Mar 17;93(3):243-249. Epub 2018 Oct 17.

Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Haemophilus influenzae, a frequent colonizer of the respiratory tract, is the causative agent of several clinically important infections. In cases that require therapeutic intervention, laboratory susceptibility testing can detect beta-lactam antibiotic resistance and guide the best treatment course. In the absence of a beta-lactamase, beta-lactam resistance may be due to an altered form of the PBP3 protein, encoded by the ftsI gene. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.009DOI Listing
March 2019
4 Reads

Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults.

Multidiscip Respir Med 2018 2;13:40. Epub 2018 Nov 2.

2Preventive Medicine Department, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.

Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (, , and ). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of the I gene among isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is performed for PK/PD susceptibility interpretation. Read More

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https://mrmjournal.biomedcentral.com/articles/10.1186/s40248
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http://dx.doi.org/10.1186/s40248-018-0152-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214181PMC
November 2018
20 Reads

Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: a nested case-control study.

BMC Infect Dis 2018 Nov 6;18(1):549. Epub 2018 Nov 6.

Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan, 185, Ghent, Belgium.

Background: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes.

Methods: In a nested case-control study, vaginal swabs from 79 pregnant women, i. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3455-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219184PMC
November 2018
19 Reads

Transcriptomics of Haemophilus (Glässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens.

BMC Vet Res 2018 Nov 6;14(1):326. Epub 2018 Nov 6.

Microbiology & Immunology Section, Animal Health Department, Faculty of Veterinary Medicine, University of León, León, Spain.

Background: Haemophilus (Glässerella) parasuis is the etiological agent of Glässer's disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly on the study of outer membrane proteins. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1647-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219065PMC
November 2018
7 Reads

Airway infection with Nontypeable Haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice.

J Steroid Biochem Mol Biol 2019 Mar 3;187:42-51. Epub 2018 Nov 3.

Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium. Electronic address:

Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive inflammatory response of the airways, is often complicated by exacerbations. Vitamin D deficiency has been associated with an increased risk for COPD and may predispose COPD patients to a higher exacerbation rate, particularly during smoking. In the current study, we investigated the effect of vitamin D deficiency and cigarette smoke (CS)-exposure on lung inflammation and bacterial clearance after an acute infection with Nontypeable Haemophilus influenzae (NTHi). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183045
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http://dx.doi.org/10.1016/j.jsbmb.2018.10.021DOI Listing
March 2019
11 Reads

Insights into the population structure and pan-genome of Haemophilus influenzae.

Infect Genet Evol 2019 Jan 31;67:126-135. Epub 2018 Oct 31.

Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal. Electronic address:

The human-restricted bacterium Haemophilus influenzae is responsible for respiratory infections in both children and adults. While colonization begins in the upper airways, it can spread throughout the respiratory tract potentially leading to invasive infections. Although the spread of H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183048
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http://dx.doi.org/10.1016/j.meegid.2018.10.025DOI Listing
January 2019
12 Reads

Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases.

Actas Dermosifiliogr 2019 Jan - Feb;110(1):38-42. Epub 2018 Oct 31.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

Introduction: The incidence of urethritis due to Haemophilus species is increasing. The main aim of this study was to describe the clinical and microbiological characteristics of patients with this form of urethritis. A secondary aim was to discuss the adequacy of treatments in patients with different types of antibiotic resistance. Read More

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http://dx.doi.org/10.1016/j.ad.2018.09.003DOI Listing
October 2018
4 Reads

Ceftobiprole Activity against Gram-Positive and -Negative Pathogens Collected from the United States in 2006 and 2016.

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

JMI Laboratories, North Liberty, Iowa, USA.

Ceftobiprole is an advanced cephalosporin with potent activity against Gram-positive and Gram-negative bacteria that has been approved in many European and non-European countries to treat community- and hospital-acquired pneumonia (excluding ventilator-associated pneumonia). This study reports on the activity of ceftobiprole against a large set of clinical isolates obtained from hospitalized patients in the United States in 2016 that caused serious infections, including pneumonia, bacteremia, and skin and skin structure infections. To assess any potential temporal changes in ceftobiprole activity, the 2016 results were compared to corresponding MIC data from a 2006 U. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01566-18
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http://dx.doi.org/10.1128/AAC.01566-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325186PMC
January 2019
5 Reads

secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

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https://wellcomeopenresearch.org/articles/3-65/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
12 Reads

Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study.

PLoS One 2018 18;13(10):e0205814. Epub 2018 Oct 18.

Bausch + Lomb, Rochester, New York, United States of America.

The Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study evaluates in vitro antibiotic resistance among Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae isolates from ocular infections. Here we report resistance rates and trends among conjunctival-sourced ocular isolates collected across the US from 2009 through 2016. A total of 1198 conjunctival isolates (483 S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193682PMC
October 2018
3 Reads

Concurrent infection of monocyte-derived macrophages with porcine reproductive and respiratory syndrome virus and Haemophilus parasuis: A role of IFNα in pathogenesis of co-infections.

Vet Microbiol 2018 Nov 18;225:64-71. Epub 2018 Sep 18.

Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic. Electronic address:

Porcine reproductive and respiratory syndrome virus (PRRSV) predisposes pigs to secondary bacterial infection caused by Haemophilus parasuis. The aim of the present study was to analyse the immune response of monocyte-derived macrophages (MDMs), serving as a model of macrophages accumulating at the site of inflammation. The second part of the study was focused on the role of IFNα in the production of inflammatory cytokines in co-infected MDMs. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.09.016DOI Listing
November 2018
2 Reads

Antimicrobial activity of ceftaroline and comparator agents tested against organisms isolated from patients with community-acquired bacterial pneumonia in Europe, Asia, and Latin America.

Int J Infect Dis 2018 Dec 10;77:82-86. Epub 2018 Oct 10.

JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.

Objective: To evaluate the potency and spectrum of ceftaroline and comparator agents tested against contemporary bacteria isolated from patients with community-acquired bacterial pneumonia (CABP) in Europe (EUR), Asia-Pacific (APAC), and Latin America (LATAM).

Methods: A total of 4321 bacterial isolates were collected consecutively by the SENTRY Antimicrobial Surveillance Program in 2015-2017 from 65 medical centers located in Western Europe (W-EUR; 21 centers in 10 nations), Eastern Europe and the Mediterranean region (E-EUR; 15 centers in 11 nations), APAC (18 centers in nine nations), and LATAM (11 centers in nine nations). Isolates were collected from lower respiratory tract specimens, and an isolate obtained from an outpatient or earlier than 48h after hospitalization was considered community-acquired. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183455
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http://dx.doi.org/10.1016/j.ijid.2018.10.004DOI Listing
December 2018
4 Reads

Community-acquired acute meningitis and encephalitis: a narrative review.

Authors:
Miles H Beaman

Med J Aust 2018 Nov 15;209(10):449-454. Epub 2018 Oct 15.

Western Diagnostic Pathology, Perth, WA

Meningitis and encephalitis are medical emergencies. Patients need prompt evaluation and immediate empiric therapy to reduce the likelihood of fatal outcomes and chronic neurological sequelae. Conjugate bacterial vaccines have significantly reduced the incidence of bacterial meningitis, especially in children. Read More

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November 2018
20 Reads

Respiratory Microbiota Predicts Clinical Disease Course of Acute Otorrhea in Children With Tympanostomy Tubes.

Pediatr Infect Dis J 2018 Oct 5. Epub 2018 Oct 5.

Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Acute otitis media (AOM) is one of the most common childhood infections, generally thought to be caused by ascension of bacteria from the nasopharynx (NP) to the middle ear. Using 16S rRNA-based sequencing, we evaluated the relationship between the NP and middle ear fluid (MEF) microbiota in children with acute otitis media with tympanostomy tubes (AOMT) as a proxy for AOM, and explored whether microbiota profiling predicts natural disease course.

Methods: Microbiota profiles of paired NP and MEF samples of 94 children aged below five years with uncomplicated AOMT were determined. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9651
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http://dx.doi.org/10.1097/INF.0000000000002215DOI Listing
October 2018
8 Reads

Increasing trend in invasive non-typeable Haemophilus influenzae disease and molecular characterization of the isolates, Italy, 2012-2016.

Vaccine 2018 10 3;36(45):6615-6622. Epub 2018 Oct 3.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

Routine immunization of infants with conjugate vaccines against Haemophilus influenzae type b (Hib) has greatly reduced the incidence of invasive Hib disease; however changes in the epidemiology of H. influenzae disease have occurred. We describe the epidemiology of invasive H. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.09.060DOI Listing
October 2018
5 Reads

Antibiotic Resistance Among Pediatric-Sourced Ocular Pathogens: 8-Year Findings From the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) Surveillance Study.

Pediatr Infect Dis J 2019 Feb;38(2):138-145

Pharmaceutical Medical Affairs, Bausch + Lomb, Rochester, New York.

Background: The Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) study is a nationwide longitudinal antibiotic resistance surveillance program specific to bacterial pathogens commonly encountered in ocular infections. We evaluated in vitro resistance rates and trends among isolates obtained from pediatric patients (≤17 years of age).

Methods: Clinical centers across the United States were invited to submit ocular isolates of Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Haemophilus influenzae and Pseudomonas aeruginosa to a central laboratory. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9651
Publisher Site
http://dx.doi.org/10.1097/INF.0000000000002206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343952PMC
February 2019
6 Reads