17,417 results match your criteria Haemophilus Influenzae Infections

-Cause of Nonspecific Acute Sinusitis: First Case Report and Review of Literature.

Microorganisms 2022 Jun 9;10(6). Epub 2022 Jun 9.

Department of Clinical Microbiology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.

Although most sinus infections are viral, potential bacterial pathogens such as , and can migrate during a viral respiratory infection from the nasopharynx into the sinus cavity causing sinusitis. is a commensal of the external auditory canal and is considered one of the potential middle ear pathogens. Unlike most otopathogens, is rarely found in the nasopharynx of healthy individuals. Read More

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Use of Inhaled Corticosteroids and Risk of Acquiring in Patients with Chronic Obstructive Pulmonary Disease.

J Clin Med 2022 Jun 20;11(12). Epub 2022 Jun 20.

Department of Internal Medicine, Section of Respiratory Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.

Inhaled corticosteroids (ICS) are widely used in chronic obstructive pulmonary disease (COPD), despite the known risk of severe adverse effects including pulmonary infections. Our study investigates the risk of acquiring a positive airway culture with use of ICS in outpatients with COPD. We conducted an epidemiological cohort study using data from 1 January 2010 to 19 February 2018, including 21,218 outpatients with COPD in Denmark. Read More

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Decreased Antibiotic Consumption Coincided with Reduction in Bacteremia Caused by Bacterial Species with Respiratory Transmission Potential during the COVID-19 Pandemic.

Antibiotics (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Nonpharmaceutical interventions implemented during the COVID-19 pandemic (2020-2021) have provided a unique opportunity to understand their impact on the wholesale supply of antibiotics and incidences of infections represented by bacteremia due to common bacterial species in Hong Kong. The wholesale antibiotic supply data (surrogate indicator of antibiotic consumption) and notifications of scarlet fever, chickenpox, and tuberculosis collected by the Centre for Health Protection, and the data of blood cultures of patients admitted to public hospitals in Hong Kong collected by the Hospital Authority for the last 10 years, were tabulated and analyzed. A reduction in the wholesale supply of antibiotics was observed. Read More

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Blood Eosinophils and Chronic Obstructive Pulmonary Disease: A GOLD Science Committee 2022 Review.

Am J Respir Crit Care Med 2022 Jun 23. Epub 2022 Jun 23.

University of Exeter College of Medicine, University of Exeter Medical School, Exeter, United Kingdom of Great Britain and Northern Ireland.

COPD is a heterogeneous condition. Some patients benefit from treatment with inhaled corticosteroids (ICS) but this requires a precision medicine approach, based on clinical characteristics (phenotyping) and biological information (endotyping) in order to select patients most likely to benefit. The GOLD 2019 report recommended using exacerbation history combined with blood eosinophil counts (BEC) to identify such patients. Read More

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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study.

BMJ Open 2022 Jun 21;12(6):e057957. Epub 2022 Jun 21.

National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Objective: To identify aetiologies of childhood community-acquired pneumonia (CAP) based on a comprehensive diagnostic approach.

Design: 'Partnerships for Enhanced Engagement in Research-Pneumonia in Paediatrics (PEER-PePPeS)' study was an observational prospective cohort study conducted from July 2017 to September 2019.

Setting: Government referral teaching hospitals and satellite sites in three cities in Indonesia: Semarang, Yogyakarta and Tangerang. Read More

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Case Report: Whole-Genome Sequencing of Serially Collected From a Patient With Common Variable Immunodeficiency Reveals Within-Host Evolution of Resistance to Trimethoprim-Sulfamethoxazole and Azithromycin After Prolonged Treatment With These Antibiotics.

Front Cell Infect Microbiol 2022 1;12:896823. Epub 2022 Jun 1.

Department of Microbiology, Vestfold Hospital Trust, Tønsberg, Norway.

We report within-host evolution of antibiotic resistance to trimethoprim-sulfamethoxazole and azithromycin in a nontypeable strain from a patient with common variable immunodeficiency (CVID), who received repeated or prolonged treatment with these antibiotics for recurrent respiratory tract infections. Whole-genome sequencing of three longitudinally collected sputum isolates during the period April 2016 to January 2018 revealed persistence of a strain of sequence type 2386. Reduced susceptibility to trimethoprim-sulfamethoxazole in the first two isolates was associated with mutations in genes encoding dihydrofolate reductase ( and its promotor region, dihydropteroate synthase (), and thymidylate synthase (), while subsequent substitution of a single amino acid in dihydropteroate synthase (G225A) rendered high-level resistance in the third isolate from 2018. Read More

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Metal nanoparticles and nanoparticle composites are effective against Haemophilus influenzae, Streptococcus pneumoniae, and multidrug-resistant bacteria.

J Microbiol Immunol Infect 2022 Jun 9. Epub 2022 Jun 9.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Background: Treatment for lower respiratory tract infection caused by multidrug-resistant organisms (MDRO) are often limited. This study explored the activity of different metal nanoparticles against several respiratory pathogens including MDROs.

Methods: Clinical isolates of carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Klebsiella pneumoniae (CRKP), Pseudomonas aeruginosa, Haemophilus influenzae, methicillin-resistant Staphylococcus aureus (MRSA), and Streptococcus pneumoniae were tested for in vitro susceptibilities to various antibiotics and nanoparticles. Read More

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Cardiobacterium hominis endocarditis incidentally diagnosed following an aortic valve replacement surgery.

IDCases 2022 6;29:e01529. Epub 2022 Jun 6.

Mayo Clinic Alix School of Medicine, Rochester, MN, USA.

Background: () is the part of the HACEK group ( that accounts for the majority of the Gram-negative infective endocarditis cases. Historically, the fastidious characteristics of these microorganisms proved challenging to many clinicians. Advances in microbiological identification of culture-negative endocarditis; however, may be the reason for the rising incidence of these infections. Read More

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Mucosal immunity of mannose-modified chitosan microspheres loaded with the nontyepable Haemophilus influenzae outer membrane protein P6 in BALB/c mice.

PLoS One 2022 10;17(6):e0269153. Epub 2022 Jun 10.

Department of Microbiology, Hebei North University, Zhangjiakou, Hebei Province, China.

Nontypeable Haemophilus influenzae (NTHi) is a common opportunistic pathogen that colonizes the nasopharynx. NTHi infections result in enormous global morbidity in two clinical settings: otitis media in children and acute exacerbation of chronic obstructive pulmonary disease (COPD) in adults. Thus, there is an urgent need to design and develop effective vaccines to prevent morbidity and reduce antibiotic use. Read More

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Impact of delayed processing of positive blood cultures on organism detection: a prospective multi-centre study.

BMC Infect Dis 2022 Jun 4;22(1):517. Epub 2022 Jun 4.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Blood cultures remain the gold standard investigation for the diagnosis of bloodstream infections. In many locations, quality-assured processing of positive blood cultures is not possible. One solution is to incubate blood cultures locally, and then transport bottles that flag positive to a central reference laboratory for organism identification and antimicrobial susceptibility testing. Read More

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Characterization of a universal neutralizing monoclonal antibody against Glaesserella parasuis CdtB.

Vet Microbiol 2022 Jul 27;270:109446. Epub 2022 Apr 27.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, Hubei 430070, China; International Research Center for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, Hubei 430070, China. Electronic address:

Glaesserella parasuis is the etiological agent of Glässer's disease. Although present as a symbiotic bacterium in the respiratory tract of healthy pigs, G. parasuis invades piglets under stress conditions and causes severe systemic infection characterized by fibrinous polyserositis, polyarthritis, and meningitis, which caused high mortality in weaned and nursery herds. Read More

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Pathogen- and Type-Specific Changes in Invasive Bacterial Disease Epidemiology during the First Year of the COVID-19 Pandemic in The Netherlands.

Microorganisms 2022 May 5;10(5). Epub 2022 May 5.

Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

COVID-19 control measures have resulted in a decline in invasive bacterial disease caused by (IMD), (IPD), and (Hi-D). These species comprise different serogroups and serotypes that impact transmissibility and virulence. We evaluated type- and pathogen-specific changes in invasive bacterial disease epidemiology in the Netherlands during the first year of the SARS-CoV-2 pandemic. Read More

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Changes in Invasive and Infections in France during the COVID-19 Pandemic.

Microorganisms 2022 Apr 26;10(5). Epub 2022 Apr 26.

Invasive Bacterial Infections, Institut Pasteur, 75724 Paris, France.

Since the appearance of COVID-19 in January 2020, invasive bacterial infections have decreased significantly worldwide. However, alterations in age and sex distributions, clinical forms, phenotypes, and genotypes of isolates have not been analyzed. Our goal is to present and discuss these data considering the current COVID-19 pandemic situation. Read More

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The first case of cholecytitis caused by Aggregatibacter kilianii in Korea.

BMC Infect Dis 2022 May 26;22(1):497. Epub 2022 May 26.

Department of Laboratory Medicine, Kosin Gospel University Hospital, 262 Gamchen-ro, Seo-gu, 49267, Busan, Korea.

Background: The bacterial genus Aggregatibacter was categorized in 2006 to accommodate the former Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, and H. segnis species. Aggregatibacter kilianii is a normal resident of the human upper respiratory tract but can also cause serious infections. Read More

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Synthetic Glycans to Improve Current Glycoconjugate Vaccines and Fight Antimicrobial Resistance.

Chem Rev 2022 May 24. Epub 2022 May 24.

GSK, R&D, Via Fiorentina 1, 53100 Siena, Italy.

Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different microorganisms, including the bacteria , , , , , , , non-typhoidal , and , and the fungus , have been identified by the WHO and CDC as urgent or serious AMR threats. Others, such as group A and B , are classified as concerning threats. Read More

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Microbiology and outcome of pediatric orbital cellulitis in a Tertiary Eye Care Center in Saudi Arabia after the routine administration of Type B vaccine.

Saudi J Ophthalmol 2021 Jul-Sep;35(3):239-243. Epub 2022 Apr 18.

Department of Ophthalmology, Oculoplastic and Reconstructive Surgery Division, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Purpose: To evaluate the incidence of pediatric related orbital cellulitis after the routine administration of the vaccine in Saudi Arabia and to identify the most common pathogens, predisposing factors, related complications, and the need for surgical intervention.

Methods: A retrospective chart review was performed of patients with a discharge diagnosis of orbital cellulitis who presented to the King Abdul Aziz University Hospital, Riyadh, Saudi Arabia. Saudi children born between 2000 and 2016 were included. Read More

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Antimicrobial resistance among Haemophilus influenzae isolates responsible for lower respiratory tract infections in Poland, 2005-2019.

Eur J Clin Microbiol Infect Dis 2022 Jun 18;41(6):961-969. Epub 2022 May 18.

Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland.

Haemophilus influenzae is a human-specific pathogen responsible for respiratory tract infections, meningitis, and sepsis. The study aimed to characterize antibiotic resistance in H. influenzae strains isolated from patients with lower respiratory tract infections over 15 years in Poland. Read More

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Utility of Polymerase Chain Reaction in Nasopharyngeal Swabs for Identifying Respiratory Bacteria Causing Community-Acquired Pneumonia.

Microbiol Spectr 2022 May 18:e0037922. Epub 2022 May 18.

Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland.

Timely identification of a pathogen in lower respiratory tract infections (LRTI) can support appropriate antibiotics use. The difficulty of obtaining lower respiratory tract (LRT) samples limits the utility of point-of-care syndromic molecular assays. We assessed the performance of the FilmArray Pneumonia plus panel (FilmArray PP) in nasopharyngeal (NP) swab for detection of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Read More

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Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine.

Acta Biomed 2022 05 11;93(2):e2022238. Epub 2022 May 11.

State Institution "National Institute of Tuberculosis and Pulmonology. F.G. Yanovsky National Academy of Medical Sciences of Ukraine", Kyiv .

Background And Aim: Empiric therapy of community-acquired pneumonia (CAP) remains the standard care and guidelines are mostly based on published data from the United States or Europe. In this study, we determined the bacterial etiology of CAP and evaluated the clinical outcomes under antimicrobial treatment of CAP in Ukraine.

Methods: A total of 98 adult subjects with CAP and PORT risk II-IV were recruited for the study. Read More

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Etiology of meningitis among adults in three quaternary hospitals in Mozambique, 2016-2017: The role of HIV.

PLoS One 2022 11;17(5):e0267949. Epub 2022 May 11.

Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.

Background: Meningitis remains an important cause of morbi-mortality in adults in sub-Saharan Africa. Data on the etiological investigation of meningitis in adults in Mozambique is limited and most studies were conducted in southern Mozambique. Identification of the etiology of meningitis in adults are crucial to guide prevention and treatments strategies. Read More

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Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study.

Lancet Microbe 2022 May 25;3(5):e357-e365. Epub 2022 Mar 25.

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address:

Background: Pneumonia is a leading cause of death worldwide and is a major health-care challenge in people living with HIV. Despite this, the causes of pneumonia in this population remain poorly understood. We aimed to assess the feasibility of metatranscriptomics for epidemiological surveillance of pneumonia in patients with HIV in Uganda. Read More

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Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomics.

Lancet Microbe 2022 Apr 9;3(4):e284-e293. Epub 2022 Mar 9.

Department of Biostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.

Background: Lower respiratory tract infections (LRTI) are a leading cause of critical illness and mortality in mechanically ventilated children; however, the pathogenic microbes frequently remain unknown. We combined traditional diagnostics with metagenomic next generation sequencing (mNGS) to evaluate the cause of LRTI in critically ill children.

Methods: We conducted a prospective, multicentre cohort study of critically ill children aged 31 days to 17 years with respiratory failure requiring mechanical ventilation (>72 h) in the USA. Read More

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Microbiome Profiling of Enterotoxigenic Escherichia coli (ETEC) Carriers Highlights Signature Differences between Symptomatic and Asymptomatic Individuals.

mBio 2022 May 10:e0015722. Epub 2022 May 10.

Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children in low- and middle-income countries (LMICs). However, large-scale pathogen burden studies in children have identified ETEC in the guts of both symptomatic patients and controls. The factors that influence this balance are poorly understood, but it is postulated that the gut microbiome may play a role in either resistance or progression to disease. Read More

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Pulmonary Infections in People Living with HIV.

Radiol Clin North Am 2022 May;60(3):507-520

Department of Infectious Diseases, Hospital de la Santa Creu i Sant Pau, Barcelona, Universidad Autónoma de Barcelona, Carrer Sant Quintí, 89, Barcelona 08041, Spain; Institut de Recerca Biomèdica del Hospital de Sant Pau, Carrer Sant Quintí, 77, Barcelona 08041, Spain.

Despite the development of combination antiretroviral therapy (cART) infections continue to cause significant morbidity and mortality among people living with HIV (PLWH). Pulmonary infections with Streptococcus pneumoniae, Haemophilus influenza, and Staphylococcus aureus remain common. One-third of PLWH worldwide are infected with tuberculosis and the infection manifests at any stage of HIV infection. Read More

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High prevalence of small intestine bacteria overgrowth and asymptomatic carriage of enteric pathogens in stunted children in Antananarivo, Madagascar.

PLoS Negl Trop Dis 2022 05 9;16(5):e0009849. Epub 2022 May 9.

Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France.

Environmental Enteric Dysfunction (EED) refers to an incompletely defined syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the small intestine. It is widespread among children and adults in low- and middle-income countries and is also associated with poor sanitation and certain gut infections possibly resulting in an abnormal gut microbiota, small intestinal bacterial overgrowth (SIBO) and stunting. We investigated bacterial pathogen exposure in stunted and non-stunted children in Antananarivo, Madagascar by collecting fecal samples from 464 children (96 severely stunted, 104 moderately stunted and 264 non-stunted) and the prevalence of SIBO in 109 duodenal aspirates from stunted children (61 from severely stunted and 48 from moderately stunted children). Read More

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Safety and immunogenicity of three doses of non-typeable Haemophilus influenzae-Moraxella catarrhalis (NTHi-Mcat) vaccine when administered according to two different schedules: a phase 2, randomised, observer-blind study.

Respir Res 2022 May 4;23(1):114. Epub 2022 May 4.

GSK, Siena, Italy.

Background: Non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) infections are frequently associated with exacerbations of chronic obstructive pulmonary disease (COPD). Results were reported with a two-dose (0-2 months) schedule of an investigational AS01-adjuvanted NTHi-Mcat vaccine containing three surface proteins from NTHi and one from Mcat. We evaluated the safety and immunogenicity of three NTHi-Mcat vaccine doses administered in two different schedules to adults with a smoking history (≥ 10 pack-years), immunologically representing the COPD population. Read More

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Evaluation of the In Vitro Antimicrobial Activities of Delphinium roylei: An Insight from Molecular Docking and MD-Simulation Studies.

Med Chem 2022 04 29. Epub 2022 Apr 29.

Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar-190006, India.

Ethnopharmacological Relevance: The burden of antimicrobial resistance demands a continued search for new antimicrobial drugs. The synthetic drugs which are used clinically have serious side effects. Natural products or compounds derived from natural sources show diversity in structure and play an essential role in drug discovery and development. Read More

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BIGDATA: A Protocol to Create and Extend a 25-Year Clinical Trial and Observational Data Asset to Address Key Knowledge Gaps in Otitis Media and Hearing Loss in Australian Aboriginal and Non-Aboriginal Children.

Front Pediatr 2022 14;10:804373. Epub 2022 Apr 14.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Introduction: Otitis media (OM) is a common childhood illness, often resolving without intervention and acute and long-term complications are rare. However, Australian Aboriginal and Torres Strait Islander infants and children experience a high burden of OM and are at high risk of complications (tympanic membrane perforation and chronic infections). Bacterial OM is commonly associated with , non-typeable , and . Read More

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One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study.

Adv Ther 2022 06 28;39(6):3031-3041. Epub 2022 Apr 28.

Institute Pasteur, 25-28 Rue du Dr Roux, 75015, Paris, France.

Introduction: COMBAT is a prospective, multicentre cohort study that enrolled consecutive adults with community-acquired bacterial meningitis (CABM) in 69 participating centres in France between February 2013 and July 2015 and followed them for 1 year.

Methods: Patients aged at least 18 years old, hospitalised with CABM were followed during their hospitalisation and then contacted by phone 12 months after enrolment. Here we present the prevalence of sequelae at 12 months in a subgroup of patients with meningococcal meningitis. Read More

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Emergence of genital infections due to Haemophilus pittmaniae and Haemophilus sputorum.

Infect Dis Now 2022 Jun 26;52(4):227-229. Epub 2022 Apr 26.

Laboratory of Microbiology, Virgen de las Nieves University Hospital-IBS Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Department of Microbiology, School of Medicine and PhD Program in Clinical Medicine and Public Health, University of Granada-IBS, Granada, PC, 18010, Spain.

Background: We report for the first time the association of Haemophilus pittmaniae and Haemophilus sputorum with urethritis in men who have sex with men and who engage in unprotected intercourse.

Patients And Methods: A search for genital pathogens was conducted using urethral exudate cultures and PCR tests for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma spp., and Ureaplasma spp. Read More

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