4,238,432 results match your criteria Haema AA­Aua[Journal]


Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Endocrinology Unit of University Hospital, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective:  Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population.

Methods:  A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. Read More

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http://dx.doi.org/10.1055/s-0039-1687860DOI Listing

Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

Respiration 2019 Apr 24:1-11. Epub 2019 Apr 24.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

Background: Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support.

Objectives: The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Read More

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http://dx.doi.org/10.1159/000498972DOI Listing

Higher urinary cortisol levels associated with increased cardiovascular risk.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

G Williams, Medicine/Endocrinology, Brigham and Women's Hospital, Boston, 02115, United States.

There is conflicting data on whether variations of physiologic cortisol levels associate with cardiovascular risk. We hypothesize that prior discordant findings are related to problems associated with varying sample size, techniques for assessing cardiovascular risk, and failure to adequately account for environmental factors. We utilized a large sample size, selected the Framingham risk score to compute cardiovascular risk, and performed the study in a highly controlled setting. Read More

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http://dx.doi.org/10.1530/EC-19-0182DOI Listing

Effect of cold hip baths on blood glucose levels in patients with type 2 diabetes mellitus: a pilot study.

Diabetes Metab 2019 Apr 21. Epub 2019 Apr 21.

Assitant Medical Officer/Lecturer-II, Department of Yoga, Govt. Yoga and Naturopathy Medical College and Hospital, Arumbakkam, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.diabet.2019.04.003DOI Listing

Distribution of D and D receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat.

J Chem Neuroanat 2019 Apr 21. Epub 2019 Apr 21.

Xinxiang Key Laboratory of Molecular Neurology, Department of Human Anatomy, Xinxiang Medical University, Xinxiang 453003, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. Electronic address:

The paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating the functions of internal organs, and it is the key nucleus for coordinating endocrine, behavior and autonomic stress responses. Dopamine receptors are widely expressed in the hypothalamus and participate in the regulation of many vital activities, such as blood pressure and glycolipid metabolism, but the details of the cellular localization of dopamine receptors in the PVN are not clear. The present study investigated the distribution of D and D receptor-immunoreactive (IR) neurons in the subnuclei of the PVN and their co-labeling with vasopressin (VP) and oxytocin (OT) in rats by means of Nissl staining and immunofluorescence. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.04.002DOI Listing

Glucoregulatory activity of Vesiculin in insulin sensitive and resistant mice.

Peptides 2019 Apr 21. Epub 2019 Apr 21.

School of Biological Sciences, New Zealand; Maurice Wilkins Centre for Molecular BioDiscovery, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics, Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, and the School of Biomedicine, the Medical School, University of Manchester, Manchester M13 9WL, UK.

Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance, and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also been used as lead compounds for therapeutics targeting metabolic disease. It is therefore important to understand the activity and function of islet hormones in both their target tissues and the whole organism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193004
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http://dx.doi.org/10.1016/j.peptides.2019.04.011DOI Listing
April 2019
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Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
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Perceived Weight Status, Disease Risk and Weight Loss Among Young Adults.

S D Med 2019 Mar;72(3):102-108

Health and Nutritional Sciences Department, South Dakota State University.

Introduction: Accurate perception of overweight status can influence weight management practices and may contribute to perceived risk of weight-related diseases. Understanding how weight perception impacts weight management and perceived risks in young adults is important, as it is during this time that individuals are forming lifestyle behaviors and likely not burdened by chronic disease.

Methods: Cross-sectional data from 86 young adults (18-25 years) were analyzed. Read More

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A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value.

FEBS J 2019 Apr 24. Epub 2019 Apr 24.

Biochemistry, Biochemical Analysis& Matrix Pathobiochemistry Research Group, Department of Chemistry, University of Patras, 26504, Patras, Greece.

Hyaluronan is a unique non-sulfated glycosaminoglycan that contributes to breast cancer cells growth and functional properties, including cell migration, invasion, adhesion, as well as tumor-associated angiogenesis in different stages of breast cancer progression and especially metastasis. Latest data show that the levels of hyaluronan and/or low molecular mass hyaluronan in blood serum and plasma of breast cancer patients may be a useful biomarker for breast cancer prognosis, differential diagnosis and patients' treatment monitoring. Therefore, the qualitative and quantitative determination of hyaluronan in biological samples is an emerging area of research. Read More

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http://dx.doi.org/10.1111/febs.14860DOI Listing

Fenofibrate -a PPARα agonist- increases alcohol dehydrogenase levels in the liver: implications for its possible use as an ethanol-aversive drug.

Adicciones 2019 Mar 29;0(0):1226. Epub 2019 Mar 29.

Instituto de Ciencias Biomédicas Facultad de Ciencias de la Salud.

After ethanol consumption, disulfiram increases blood-acetaldehyde levels, generating an aversive reaction that deters alcohol drinking. Given the major secondary effects of disulfiram, finding other effective drugs to reduce alcohol consumption in individuals with alcohol-use-disorder is highly desirable. It has been reported that administering fenofibrate to high-drinking rats increases hepatic catalase levels and blood acetaldehyde after administering ethanol and a 60-70% inhibition of voluntary alcohol intake. Read More

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http://dx.doi.org/10.20882/adicciones.1226DOI Listing

Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.

PLoS One 2019 24;14(4):e0215994. Epub 2019 Apr 24.

Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China.

Prenatal hypoxia can induce cardiovascular diseases in the offspring. This study determined whether and how prenatal hypoxia may cause malignant hypertension and impaired vascular functions in spontaneous hypertension rat (SHR) offspring at adolescent stage. Pregnant SHR were placed in a hypoxic chamber (11% O2) or normal environment (21% O2) from gestational day 6 until birth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215994PLOS

Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia.

PLoS One 2019 24;14(4):e0216162. Epub 2019 Apr 24.

Department of Medical and Surgical Sciences and Advanced Technology, Section of Neurosciences, University of Catania, Catania, Italy.

Background: Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact on cerebral hemodynamics are scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment.

Methods: A sample of non-demented elderly patients with WMLs was consecutively recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216162PLOS

Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep.

PLoS One 2019 24;14(4):e0215842. Epub 2019 Apr 24.

School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, Australia.

Plasma pharmacokinetic profiles and the anti-inflammatory efficacy of meloxicam were determined when administered subcutaneously (SC) or intramuscularly (IM) to sheep. Merino ewes were initially injected with 0.1 mL of oil of turpentine into a forelimb to induce inflammation, followed by either 1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215842PLOS

The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression.

PLoS One 2019 24;14(4):e0215601. Epub 2019 Apr 24.

Department of Medicine, University of Washington, Seattle, WA, United States of America.

During periods in which glucose absorption from the gastrointestinal (GI) tract is insufficient to meet body requirements, hepatic gluconeogenesis plays a key role to maintain normal blood glucose levels. The current studies investigated the role in this process played by vasodilatory-associated phosphoprotein (VASP), a protein that is phosphorylated in hepatocytes by cAMP/protein kinase A (PKA), a key mediator of the action of glucagon. We report that following stimulation of hepatocytes with 8Br-cAMP, phosphorylation of VASP preceded induction of genes encoding key gluconeogenic enzymes, glucose-6-phosphatase (G6p) and phosphoenolpyruvate carboxykinase (Pck1), and that VASP overexpression enhanced this gene induction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215601PLOS

Comparative evaluation of cerebral gliomas using rCBV measurements during sequential acquisition of T1-perfusion and T2*-perfusion MRI.

PLoS One 2019 24;14(4):e0215400. Epub 2019 Apr 24.

Philips Health Tech Asia Pacific, Minato-ku Tokyo, Japan.

Objective: To assess the inter-technique agreement of relative cerebral blood volume (rCBV) measurements obtained using T1- and T2*-perfusion MRI on 3T scanner in glioma patients.

Methods: A total of 49 adult patients with gliomas underwent both on T1- and T2*-perfusion in the same scanning session, and rCBV maps were estimated using both methods. For the quantitative analysis; Two independent observers recorded the rCBV values from the tumor as well as contralateral brain tissue from both T1- and T2*-perfusion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215400PLOS

Mental and physical health effects of meaningful work and rewarding family responsibilities.

PLoS One 2019 24;14(4):e0214916. Epub 2019 Apr 24.

Department of Public Health, University of Copenhagen. Copenhagen, Denmark.

Positive feelings about work and family responsibilities benefit psychological well-being, but their physical health effects remain unexplored. The study assessed whether meaningful work and reward from taking care of family benefitted physical health to the same degree as mental health. Participants were 181 Danes aged 49-51. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214916PLOS

Association between serum 25-hydroxyvitamin D and diabetic kidney disease in Chinese patients with type 2 diabetes.

PLoS One 2019 24;14(4):e0214728. Epub 2019 Apr 24.

Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Objective: The objective was to assess the association between 25-hydroxyvitamin D (25OHD) level and diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes.

Methods: Data pertaining to 351 in-patients with type 2 diabetes were collected. Subjects were classified into three groups based on the level of urinary albumin-to-creatinine ratio (UACR). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214728PLOS

Host immune responses induced by specific Mycobacterium leprae antigens in an overnight whole-blood assay correlate with the diagnosis of paucibacillary leprosy patients in China.

PLoS Negl Trop Dis 2019 Apr 24;13(4):e0007318. Epub 2019 Apr 24.

Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Leprosy, caused by Mycobacterium leprae, affects over 200,000 people annually worldwide and remains endemic in the ethnically diverse, mountainous and underdeveloped southwestern provinces of China. Delayed diagnosis of leprosy persists in China, thus, additional knowledge to support early diagnosis, especially early diagnosis of paucibacillary (PB) patients, based on the host immune responses induced by specific M. leprae antigens is needed. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007318DOI Listing

The Role of Regulatory B Cells in Patients with Acute Myeloid Leukemia.

Med Sci Monit 2019 Apr 24;25:3026-3031. Epub 2019 Apr 24.

China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Regulatory B (Breg) cells are a group of B cells with immunomodulatory function, which mainly exert negative immunomodulatory function by secreting IL-10 and other cytokines. Due to their immunoregulatory properties, Breg cells may participate in the pathogenesis of acute myeloid leukemia (AML). This study was designed to explore the frequency of Breg cells and the relationship between the Breg cells and clinical data in patients with AML. Read More

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http://dx.doi.org/10.12659/MSM.915556DOI Listing

The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Physiology, School of Medicine, Selçuk University, Konya, Turkey.

Background The objective of this investigation was to examine the impact of silymarin supplementation on locomotion, anxiety-related behavior, learning, and memory via several behavioral tests, such as open field, elevated plus maze, and Morris water maze tests in streptozotocin-induced diabetic rats. Methods The rats were divided into the control, diabetes, silymarin, and diabetes plus silymarin groups. On the 30th-35th days of the study, several behavioral tests were performed and blood and brain tissue samples were taken and brain-derived neurotrophic factor (BDNF) and histone deacetylase 3 (HDAC3) levels were analyzed. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0109DOI Listing

Long intervals between two doses of HPV vaccines and magnitude of the immune response: A post-hoc analysis of two clinical trials.

Hum Vaccin Immunother 2019 Apr 24. Epub 2019 Apr 24.

c Division of High-Consequence Pathogens and Pathology , Centers for Disease Control and Prevention , Atlanta , USA.

The objective of this analysis was to compare the anti-HPV GMTs and their distribution after a 6- month or a 3-8 year interval between two HPV vaccine doses. The results from two clinical trials, conducted by the same team in the same region, with serological assays performed at the same laboratory using the same ELISA methodology were compared. In the first study, 173 9-10 year-old girls and boys received two doses of 9vHPV vaccine at a 6-month interval; in the second study, 31 girls vaccinated with one dose of 4vHPV at the age of 9-14 years received a dose of 9vHPV 3-8 years later (mean 5. Read More

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http://dx.doi.org/10.1080/21645515.2019.1605278DOI Listing

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins.

J Proteome Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Molecular and Biomedical Sciences , Jožef Stefan Institute , Jamova cesta 39 , SI-1000 Ljubljana , Slovenia.

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes ( Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active proteins and peptides. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00120DOI Listing

Lactate dehydrogenase and baseline markers associated with clinical outcomes of advanced esophageal squamous cell carcinoma patients treated with camrelizumab (SHR-1210), a novel anti-PD-1 antibody.

Thorac Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: A small proportion of patients with advanced esophageal squamous cell carcinoma (ESCC) could benefit from immune checkpoint inhibitors; however, reliable peripheral blood biomarkers for outcomes of anti-PD-1 immunotherapy in ESCC have not been identified.

Methods: The data of 43 patients in the ESCC cohort of a phase I trial at our center were retrospectively reviewed. All patients were administered intravenous camrelizumab (SHR-1210), a novel anti-PD-1 antibody, at doses of 60 mg, 200 mg, or 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. Read More

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http://dx.doi.org/10.1111/1759-7714.13083DOI Listing

A Review of Deep Infiltrative Colorectal Endometriosis Treated Robotically at a Single Institution.

Int J Med Robot 2019 Apr 24:e2001. Epub 2019 Apr 24.

Department of General Surgery and Colorectal Surgery at the George Washington University Hospital, Washington, DC.

Purpose/background: Using robotic surgery, we report successful resection of deep invasive pelvic endometriosis with a multidisciplinary team of colorectal and gynecologic surgeons.

Methods/interventions: Fifteen cases of robotic assisted endometrial resections for deep invasive endometriosis were performed by a multidisciplinary team between 2013 and 2016.

Results/outcomes: The average total operative time of robotic endometrial extirpation was 342 minutes and the average blood loss was 283 cc. Read More

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http://dx.doi.org/10.1002/rcs.2001DOI Listing

Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry.

Environ Toxicol Chem 2019 Apr 24. Epub 2019 Apr 24.

CAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.

A QuEChERS based extraction and simultaneous dispersive solid phase extraction (dSPE) cleanup method was developed for contaminants of emerging concerns (CECs) in sediment samples. Hydration with phosphate buffer (pH 2.0) and salting out with NaCl and MgSO facilitated the extraction and liquid-liquid portioning of the aqueous and organic phases. Read More

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http://dx.doi.org/10.1002/etc.4450DOI Listing

The Impact of Cryopreservation-Thawing Conditions on Umbilical Cord Blood Quality and Transplantation Outcomes.

Cryo Letters 2019 Mar/Apr;40(2):83-93

Guangzhou Cord Blood Bank, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Background: Cord blood units (CBUs) go through the cryopreservation-thawing process for storage before use in transplantation. The differences in the cryopreservation-thawing process affect the quality of CBUs. The effects of the cryopreservation-thawing process on the final outcomes of CBU transplantation has not been defined well. Read More

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Application of Pectin from Aloe arborescens Mill. to the Cryopreservation of Human Leukocyte Cell Suspensions.

Cryo Letters 2019 Mar/Apr;40(2):71-76

Physiology Institute at the Komi Scientific Center of the Russian Academy of Sciences, Komi Republic, Syktyvkar, Russian Federation.

Background: The molecular weight (MW) of pectic polysaccharide АА3 equal to 150 kDa and its structure suggest that it has a non-permeating protector action.

Objective: To study the ability of low methylesterified galacturonan АА3, extracted from Aloe arborescens Mill., to influence the cryoprotective properties of the refrigerant in the cryopreservation of leukocytes (-20°С, -80°С). Read More

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Usage Patterns of GlucoNote, a Self-Management Smartphone App, Based on ResearchKit for Patients With Type 2 Diabetes and Prediabetes.

JMIR Mhealth Uhealth 2019 Apr 24;7(4):e13204. Epub 2019 Apr 24.

Department of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Preventing progression from prediabetes to diabetes-or slowing the progression of diabetes-is an urgent task worldwide. Previous studies have shown that mobile health (mHealth) may powerfully support self-management for patients with type 2 diabetes. Certainly, mHealth improves health care efficiency and gives patients convenient access to self-management of their own health. Read More

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http://mhealth.jmir.org/2019/4/e13204/
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http://dx.doi.org/10.2196/13204DOI Listing
April 2019
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Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium.

Heart Surg Forum 2019 Feb 25;22(2):E082-E087. Epub 2019 Feb 25.

Cardiovascular Surgery Department, Medicine Faculty, Bozok University, Yozgat, Turkey.

Objective: In this study, we investigated whether the addition of vitamin B complex to prime solution for cardiopulmonary bypass (CPB) in cobalamin-deficient patients undergoing on-pump coronary artery bypass grafting (CABG) helps prevent the development of postoperative delirium (POD).

Materials And Methods: In the present study, 69 of 138 patients with serum vitamin B12 levels <200 pg/mL based on the blood sample taken within 1 week prior to on-pump CABG between January 2013 and December 2017 were enrolled. The control group included 69 patients. Read More

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http://dx.doi.org/10.1532/hsf.2171DOI Listing
February 2019

Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).

Int J Vitam Nutr Res 2019 Apr 24:1-10. Epub 2019 Apr 24.

6 Associate professor of Radiology, Faculty of paramedical, Tabriz University of Medical Sciences, Tabriz, Iran.

In an attempt to investigate new strategies aimed at reducing risk factors of non-alcoholic fatty liver disease (NAFLD), effects of turmeric (Curcuma longa L.) and chicory seed (Cichorium intybus L.) supplementation was evaluated in these patients. Read More

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http://dx.doi.org/10.1024/0300-9831/a000568DOI Listing

Obesity related changes in cardiac structure and function: role of blood pressure and metabolic abnormalities.

Acta Cardiol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Dipartimento PROMISE , University of Palermo, School of Medicine , Palermo , ltaly.

Background: It has been reported that changes in cardiac structure and ventricular function associated with obesity have to be attributable to hemodynamic and non-hemodynamic alterations. Accordingly, the aim of this was to evaluate left ventricular hypertrophy (LVH) prevalence and its effect on left ventricular systolic and diastolic function in a cohort of obese patients.

Materials And Methods: LV internal diameter (LVID), left ventricular mass (LVM) and LVM/height(LVMI), relative wall thickness (RWT), LV ejection fraction (LVEF), E/A ratio, isovolumic relaxation time, deceleration time of E velocity by echocardiography and pulsed-wave Doppler and total circulating adiponectin (ADPN) by radioimmunoassay were measured in 319 obese subjects with and without LVH. Read More

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http://dx.doi.org/10.1080/00015385.2019.1598638DOI Listing

Metal-Organic Framework Nanoparticle-Assisted Cryopreservation of Red Blood Cells.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

The development of hybrid nanomaterials mimicking antifreeze proteins that can modulate/inhibit the growth of ice crystals for cell/tissue cryopreservation has attracted increasing interests. Herein, we describe the first utilization of zirconium (Zr)-based metal-organic framework (MOF) nanoparticles (NPs) with well-defined surface chemistries for the cryopreservation of red blood cells (RBCs) without the need of any (toxic) organic solvents. Distinguishing features of this cryoprotective approach include the exceptional water stability, low hemolytic activity, and the long periodic arrangement of organic linkers on the surface of MOF NPs which provide the precise spacing of hydrogen donors to recognize and match the ice crystal planes. Read More

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http://pubs.acs.org/doi/10.1021/jacs.9b00992
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http://dx.doi.org/10.1021/jacs.9b00992DOI Listing

Why do we give "orphan" approval to biologic therapies but not to extracorporeal blood purification therapies for hyperinflammatory syndromes?

Minerva Anestesiol 2019 May;85(5):465-467

Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA -

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http://dx.doi.org/10.23736/S0375-9393.19.13711-XDOI Listing

GLYCEMIC CONTROL AND BONE MINERAL DENSITY IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES.

Pediatr Diabetes 2019 Apr 24. Epub 2019 Apr 24.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Denmark.

Background/aim: Fracture risk is increased in patients with type 1 diabetes. We aimed to evaluate bone mineral density (BMD) and to identify risk factors associated to lower BMD in Danish children and adolescents with type 1 diabetes.

Methods: In this cross-sectional study, BMD and BMD Z-score were determined by dual-energy X-ray absorptiometry (DXA) from a cohort of otherwise healthy children and adolescents with type 1 diabetes. Read More

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http://dx.doi.org/10.1111/pedi.12861DOI Listing

Dual-phase CT angiography for presurgical planning in patients with vessel-depleted neck.

Head Neck 2019 Apr 24. Epub 2019 Apr 24.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.

Background: Microvascular reconstruction in vessel-depleted necks is challenging due to limited availability of recipient vessels. We examine the utility of dual-phase CT angiography (CTA), which delineates both arteries and veins, for preoperative planning in such difficult cases.

Methods: Retrospective chart review of a single surgeon from July 2013 to July 2017 in a tertiary referral center was performed. Read More

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http://dx.doi.org/10.1002/hed.25775DOI Listing

Biogenic approach to synthesize rod shaped Gd O NPs and its optimization using RSM-BBD model.

Biotechnol Prog 2019 Apr 24:e2823. Epub 2019 Apr 24.

Faculty of Chemical and Natural resources Engineering, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia.

The rare earth metal oxide nanoparticles such as gadolinium oxide nanoparticles (Gd O NPs) have been synthesized by green synthesis process using methanolic extract of Moringa oleifera (M. oleifera) peel. In this process, the Gd O NPs formation was observed at 280-300 nm in UV-Vis spectroscopy. Read More

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http://dx.doi.org/10.1002/btpr.2823DOI Listing

From fluorescent proteins to fluorogenic RNAs: tools for imaging cellular macromolecules.

Protein Sci 2019 Apr 24. Epub 2019 Apr 24.

Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, 50 South Drive MSC 8012, Bethesda, MD 20892-8012, USA.

The explosion in genome-wide sequencing has revealed that non-coding RNAs are ubiquitous and highly conserved in biology. New molecular tools are needed for their study in live cells. Fluorescent RNA-small molecule complexes have emerged as powerful counterparts to fluorescent proteins, which are well established, universal tools in the study of proteins in cell biology. Read More

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http://dx.doi.org/10.1002/pro.3632DOI Listing

Chronic inflammation during Osteoarthritis is associated with an increased expression of CD161 during advanced stage.

Scand J Immunol 2019 Apr 24:e12770. Epub 2019 Apr 24.

Department of Anatomy, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Increasing evidence suggests a role of inflammation during the pathogenesis of Osteoarthritis (OA). The local and systemic inflammation was studied in 33 patients of different KL grades, grade2 (n=11), grade3 (n=6) and grade4 (n=16). The levels of cytokines, adipokines, and matrixmetalloproteinases (MMPs) were measured in serum and synovial fluid (SF) by flow cytometry and ELISA respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12770
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http://dx.doi.org/10.1111/sji.12770DOI Listing
April 2019
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Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage.

Int J Mol Med 2019 Jun 11;43(6):2491-2498. Epub 2019 Apr 11.

Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Nucleos(t)ide analogues (NAs) are currently the most important anti‑viral treatment option for patients with chronic hepatitis B (CHB). Adefovir dipivoxil (ADV), a diester pro‑drug of adefovir, has been widely used for the clinical therapy of hepatitis B virus infection. It has been previously reported that adefovir induced chromosomal aberrations (CAs) in the in vitro human peripheral blood lymphocyte assay, while the genotoxic mechanism remains elusive. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4164DOI Listing

Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis.

Int J Mol Med 2019 Jun 9;43(6):2303-2318. Epub 2019 Apr 9.

Department of Molecular and Translational Medicine, University of Brescia, I‑25123 Brescia, Italy.

Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microRNAs (miRNAs/miR) have been described to be associated with DS, although none of them so far have been unequivocally linked to the pathology. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4158DOI Listing

Effect of Lavandula dentata extract on Ovalbumin-induced Asthma in Male Guinea Pigs.

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Biology, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.

Asthma is an inflammatory disease of the lungs, and it causes oxidative stress. Lavandula dentata is an aromatic herb with anti-oxidative and anti-inflammatory activities. This study examined the activity of L. Read More

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http://dx.doi.org/10.1590/1519-6984.191485DOI Listing

Modulating bioactivities of primary ammonium-tagged antimicrobial aliphatic polycarbonates by varying length, sequence and hydrophobic side chain structure.

Biomater Sci 2019 Apr 24. Epub 2019 Apr 24.

Graduate School of Science and Engineering, Yamagata University, Japan.

Cationic aliphatic polycarbonates bearing primary ammonium side chains have been developed with relatively high molecular weights and controlled macromolecular architectures. These polycarbonates exhibit reasonable antimicrobial activity against Gram-negative and Gram-positive bacteria. The prepared homopolymers could be effective against Gram-negative bacteria whose growth is usually inhibited by copolymers with hydrophobic comonomer units when quaternary ammonium salts (QAS) are used at the cationic side chains. Read More

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http://dx.doi.org/10.1039/c9bm00440hDOI Listing

Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma.

J Investig Allergol Clin Immunol 2019 Apr;29(2):84-93

Department of Allergy, Hospital Universitario La Paz Institute for Health Research (IdiPAZ) and CIBER of Respiratory Diseases (CIBERES), Madrid, Spain.

Eosinophilic asthma is the most common phenotype of severe asthma. It is characterized by abnormal production and release of type 2 cytokines from T helper type 2 (TH2) lymphocytes and type 2 innate lymphoid cells, such as IL-5. This leads to a persistent increase and activation of eosinophils in blood and the airways despite treatment with high-dose inhaled corticosteroids. Read More

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http://dx.doi.org/10.18176/jiaci.0385DOI Listing

Beyond Blood Smears-Qualification of the 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology, University of Washington, Seattle, Washington.

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We validated a multiplex quantitative reverse transcription-PCR (qRT-PCR) for 18S rRNA, prospectively compared blood smears and qRT-PCR for three trials, and modeled treatment effects at different biomarker-defined parasite densities to assess the impact on infection detection, symptom reduction, and measured intervention efficacy. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0094DOI Listing

Molecular Survey of Species in Shelter Cats in Rio De Janeiro: Clinical, Hematological, and Risk Factors.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

Departament of Veterinary Medicine and Surgery, Veterinary Institute, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.

The present study aimed to detect DNA in cats belonging to shelters, and to evaluate risk factors, clinical signs, and hematological abnormalities associated with infection. Complete blood counts and screening for the presence of DNA were performed on cats' ethylenediamine tetraacetic acid anticoagulant-blood samples. Eighty-three cats (39. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0585DOI Listing

Investigating specificity of the anti-hypertensive inhibitor WNK463 against With-No-Lysine kinase family isoforms via multiscale simulations.

J Biomol Struct Dyn 2019 Apr 24:1-16. Epub 2019 Apr 24.

a Discipline of Biosciences and Biomedical Engineering , Indian Institute of Technology Indore , Indore , Madhya Pradesh , India.

The With-No-Lysine (WNK) kinase family plays a significant role in regulating cation-chloride cotransporters, blood pressure and body fluid homeostasis. Mutations in the gene of WNK family, especially in WNK1 and WNK4 are responsible for pseudohypoaldosteronism type II (PHAII), characterized by hypertension. The selective inhibition of WNK1 over other isoforms has created an immense challenge in the design of an ATP competitive inhibitor due to their high conservatism. Read More

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http://dx.doi.org/10.1080/07391102.2019.1602079DOI Listing

Usability of mepolizumab single-use prefilled syringe for patient self-administration.

J Asthma 2019 Apr 24:1-10. Epub 2019 Apr 24.

g Respiratory Therapeutic Area, GSK , Research Triangle Park , NC , USA.

Objective: A liquid mepolizumab formulation in a single-use prefilled syringe (PFS) is under development. We evaluated the usability of mepolizumab self-injected via PFS by patients with severe eosinophilic asthma (SEA), or their caregivers, in clinic and at home.

Methods: This open-label, single-arm, Phase IIIa study included patients with SEA, aged ≥12 years, and receiving mepolizumab (100 mg subcutaneously) every 4 weeks for ≥12 weeks prior to screening. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2019.1604745DOI Listing
April 2019
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Examining and Understanding Value: The Impact of Preoperative Characteristics, Intraoperative Variables, and Postoperative Complications on Cost of Robotic-Assisted Laparoscopic Radical Prostatectomy.

J Endourol 2019 Apr 24. Epub 2019 Apr 24.

University of Kentucky Medical Center, 12253, Urology , 800 Rose St. , Room MS237 , Lexington, Kentucky, United States , 40536-0293 ;

Introduction And Objective: Quality-based reimbursement continues to gain popularity as value-based care becomes more prominent. Our goal is to describe the impact of preoperative characteristics, intraoperative variables, and postoperative complications on the cost of robotic-assisted laparoscopic radical prostatectomy (RALP).

Methods: Using our institution's National Surgical Quality Improvement Program (NSQIP) data, we identified minimally invasive prostatectomies performed January 2012 to March 2017. Read More

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http://dx.doi.org/10.1089/end.2019.0066DOI Listing
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