4,210,390 results match your criteria Haema AA­Aua[Journal]


Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019

dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.

J Neurosurg 2019 Feb 15:1-13. Epub 2019 Feb 15.

1Department of Neurosurgery, Peking University International Hospital.

OBJECTIVEPostoperative neurological deficits impair the overall outcome of revascularization surgery for patients with moyamoya disease (MMD). dl-3-n-butylphthalide (NBP) is approved for the treatment of ischemic stroke in China. This pilot study evaluated the effect of NBP on perioperative stroke and neurological deficits in patients with MMD. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182152DOI Listing
February 2019

Impact of decompression surgery without fusion for lumbar spinal stenosis on sagittal spinopelvic alignment: minimum 2-year follow-up.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Department of Orthopaedic Surgery, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan; and.

OBJECTIVEThe importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward to relieve their neurological symptoms, i.e. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181092DOI Listing
February 2019

Adverse events and their risk factors 90 days after cervical spine surgery: analysis from the Michigan Spine Surgery Improvement Collaborative.

J Neurosurg Spine 2019 Feb 15:1-13. Epub 2019 Feb 15.

Departments of1Neurosurgery.

OBJECTIVEThe Michigan Spine Surgery Improvement Collaborative (MSSIC) is a statewide, multicenter quality improvement initiative. Using MSSIC data, the authors sought to identify 90-day adverse events and their associated risk factors (RFs) after cervical spine surgery.METHODSA total of 8236 cervical spine surgery cases were analyzed. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18666DOI Listing
February 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.

Environ Pollut 2019 Feb 7;248:28-35. Epub 2019 Feb 7.

Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA. Electronic address:

Background: Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.129DOI Listing
February 2019

The value of delta neutrophil index in neonatal sepsis diagnosis, follow-up and mortality prediction.

Early Hum Dev 2019 Feb 13;131:6-9. Epub 2019 Feb 13.

Division of Neonatology, Department of Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, 06010, Ankara, Turkey; Division of Neonatology, Department of Pediatrics, Yildirim Beyazit University, 06800, Ankara, Turkey.

Background: The complete blood cell count (CBC) and peripheral blood smear were the most commonly ordered tests for the diagnosis of neonatal sepsis. Delta neutrophil index (DNI) shows leucocyte differentiation and calculated while CBC is performed.

Aims: We aimed to evaluate the value of DNI in neonatal sepsis. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.003DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

Prolonged cortical silent period is related to poor fitness and fatigue, but not tumor necrosis factor, in Multiple Sclerosis.

Clin Neurophysiol 2019 Feb 4;130(4):474-483. Epub 2019 Feb 4.

Recovery and Performance Laboratory, Faculty of Medicine, L.A. Miller Centre, Memorial University of Newfoundland, St. John's, NL, Canada. Electronic address:

Objective: Poor fitness among people with Multiple Sclerosis (MS) aggravates disease symptoms. Whether low fitness levels accompany brain functioning changes is unknown.

Methods: MS patients (n = 82) completed a graded maximal exercise test, blood was drawn, and transcranial magnetic stimulation determined resting and active motor thresholds, motor evoked potential latency, and cortical silent period (CSP). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.015DOI Listing
February 2019

Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

Cytokine 2019 Feb 13;115:24-31. Epub 2019 Feb 13.

Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil. Electronic address:

There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.005DOI Listing
February 2019
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A rare case of transient left ventricular apical ballooning syndrome following living donor liver transplantation: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:218-222. Epub 2019 Feb 10.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Introduction: Transient Left Ventricular Apical Balloon Syndrome (LV-ABS) is an unknown acute dysfunction of the left ventricle, which develops under emotional or physical stress events like the major surgical postoperative period.

Presentation Of Case: A 68-year-old woman diagnosed with hepatitis C cirrhosis was admitted for living donor liver transplantation (LDLT). No evidence for underlying cardiac or pulmonary disease was found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.002DOI Listing
February 2019

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever.

Int J Parasitol Drugs Drug Resist 2019 Jan 25;9:80-86. Epub 2019 Jan 25.

International Livestock Research Institute, P. O. Box 30709, Nairobi, Kenya. Electronic address:

Chemotherapy of East Coast fever, a lymphoproliferative cancer-like disease of cattle causing significant economic losses in Africa, is largely dependent on the use of buparvaquone, a drug that was developed in the late 1980's. The disease is caused by the tick-borne protozoan pathogen Theileria parva. Buparvaquone can be used prophylactically and it is also active against tropical theileriosis, caused by the related parasite Theileria annulata. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.01.002DOI Listing
January 2019

Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Eur J Med Chem 2019 Feb 4;167:133-145. Epub 2019 Feb 4.

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China. Electronic address:

A novel series of tetrahydroisoquinoline-benzimidazole hybrids have been designed and synthesized as multifunctional agents against Alzheimer's disease (AD). These compounds were evaluated for their inhibition of neuroinflammation and human β-secretase (hBACE1), and neuroprotective activity. Among them, compound BD3 possessed significant anti-neuroinflammatory activity (IC = 5. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.008DOI Listing
February 2019

Movie violence acutely affects food choices in young adults.

Eat Behav 2019 Feb 10;33:7-12. Epub 2019 Feb 10.

Nutrition Division, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Lebanon.

Background: Extensive research has been conducted to investigate the effects of media violence on attitudes, behaviors, and cardiovascular health; however, only few studies have examined its effect on appetite, eating behavior and food preferences. Little attention has been given to understand how movie genre manipulates the physiology and the eating behavior of individuals. The present study aimed at investigating the acute effect of violence content in movies on appetite perception, heart rate and blood pressure, along with food preferences and intake in young individuals. Read More

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http://dx.doi.org/10.1016/j.eatbeh.2019.02.002DOI Listing
February 2019

Foxp3+ regulatory T cells expression in neuromyelitis optica spectrum disorders.

Mult Scler Relat Disord 2019 Jan 30;30:114-118. Epub 2019 Jan 30.

Department of Neurology and the Multiple Sclerosis Center, the Agnes-Ginges Center for Neurogenetics, Hadassah- Medical Center, Hebrew University, Ein Karem, P.O.B. 12000, Jerusalem 91120, Israel. Electronic address:

Background: Alterations in the frequency or function of regulatory T cells (Tregs), which play a critical role in the maintenance of peripheral immune tolerance, are known to be involved in the pathogenesis of several autoimmune diseases. Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune inflammatory diseases of the central nervous system (CNS), of which the etiology and mechanisms underlying its development are not completely understood. Although there is increasing evidence for the involvement of effector T cells in NMOSD, no data are available regarding the role of Tregs in its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.047DOI Listing
January 2019

Arriba por la vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas.

Contemp Clin Trials 2019 Feb 13. Epub 2019 Feb 13.

University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

Background: Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidelines. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.004DOI Listing
February 2019

Regulatory T lymphocytes are associated with increased nasopharyngeal colonization in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 5;120:51-57. Epub 2019 Feb 5.

Office of Senior DVC and Provost, Swinburne University of Technology, Melbourne, Australia. Electronic address:

Objectives: Regulatory T lymphocytes (T) have been linked to survival of commensal bacteria at mucosal sites, but their presence and role in chronic otitis media (COM) and their response to otopathogens has not been evaluated previously. We investigated the association between T lymphocytes and otopathogens in COM prone and non-COM prone children.

Methods: Forty children, 2-7 years of age, scheduled for adenoidectomy were enrolled into COM (n = 20) or non-COM (n = 20) groups. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.011DOI Listing
February 2019

Computational fluid dynamics analysis of a carotid-ophthalmic aneurysm with concomitant ophthalmic artery infundibulum in a patient-specific model.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Background: Although previous studies have reported cases of coexistence of carotid-ophthalmic aneurysm (COA) and ophthalmic artery (OA) infundibulum, the hemodynamic characteristics of this complicated structure and its damaging effect on vision remain to be elucidated. The aim of this study was to analyze this specific artery structure using computational fluid dynamics (CFD) techniques.

Methods: We presented a patient diagnosed with COA, who had been suffering from blurred vision. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.002DOI Listing
February 2019

Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.

Background: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, thus leading to inappropriate treatment of this serious eye condition.

Objectives: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.017DOI Listing
February 2019

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment.

Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Tianjin Institute of Urology, Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China.

Bacillus Calmette-Guerin (BCG) is one of the most effective treatments for bladder cancer. Little attention has been paid to the possible role of neutrophils in BCG immunotherapy. In this study, we examined neutrophil extracellular traps (NETs) formation induced by BCG stimulation, and found that BCG-induced NETs exerted cytotoxicity, induced apoptosis and cell-cycle arrest, and inhibited migration in bladder tumor cells. Read More

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http://dx.doi.org/10.1016/j.clim.2019.02.005DOI Listing
February 2019

Improved survival after cord blood transplantation: single center experience in pediatric patients over a two-decade period.

Biol Blood Marrow Transplant 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA; Department of Medicine, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.02.010DOI Listing
February 2019

Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myeloid leukemia after single cord blood transplantation.

Biol Blood Marrow Transplant 2019 Feb 13. Epub 2019 Feb 13.

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

The different effects of pre-engraftment syndrome (PES) and acute graft-versus-host disease (GVHD) on transplant outcomes after cord blood transplantation (CBT) are unclear. We retrospectively evaluated the impact of PES and acute GVHD on relapse and survival after single CBT for 138 adult patients with hematological malignancies in our institute between 2004 and 2016. Multivariate analysis demonstrated that development of grade III to IV acute GVHD, particularly gut or liver involvement of acute GVHD, significantly contributed to higher non-relapse mortality (P<0. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.007DOI Listing
February 2019

In vitro toxicity assessment of zinc and nickel ferrite nanoparticles in human erythrocytes and peripheral blood mononuclear cell.

Toxicol In Vitro 2019 Feb 13. Epub 2019 Feb 13.

Nanobiology Laboratory, Department of Natural and Exact Sciences, Pontificia Universidad Católica Madre y Maestra, PUCMM, Autopista Duarte Km 1 ½, Santiago de los Caballeros, Dominican Republic. Electronic address:

Ferrite nanoparticles (NPs) have gained attention in biomedicine due to their many potential applications, such as targeted drug delivery, their use as contrast agents for magnetic resonance imaging and oncological treatments. The information about the risk effects of ferrite NPs in human blood cells is, however, scarce. To assess their potential toxicity, in vitro studies were carried out with magnetite and zinc, nickel and nickel‑zinc ferrites NPs at different concentrations (50, 100 and 200 μg·ml). Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.011DOI Listing
February 2019

Entry of therapeutics into the brain: influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Int J Pharm 2019 Feb 13. Epub 2019 Feb 13.

Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States. Electronic address:

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of drug permeation through the blood-brain barrier (BBB). For this purpose, EPSA values for 69 structurally unrelated acidic, basic, neutral and amphoteric compounds were determined by a validated SFC method. Additionally, water-accessible surface area (WASA) values for the whole dataset were calculated in silico and compared to experimentally determined EPSA values. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.008DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9.

J Control Release 2019 Feb 13. Epub 2019 Feb 13.

Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO 63110, USA; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO 63110, USA. Electronic address:

Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting. Due to its monogenic nature, HB is one of the primary targets for gene therapy. Indeed, successful correction of HB has been shown in clinical trials using gene therapy approaches. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.009DOI Listing
February 2019

A combined immunodeficiency with severe infections, inflammation and allergy caused by ARPC1B deficiency.

J Allergy Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory AMC, University of Amsterdam, The Netherlands. Electronic address:

We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.003DOI Listing
February 2019

Inhibition of HBsAg secretion by nucleic acid polymers in HepG2.2.15 cells.

Antiviral Res 2019 Feb 13. Epub 2019 Feb 13.

INRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, Laval, Canada. Electronic address:

More than 290 million people have chronic HBV infection and are at risk of developing cirrhosis and hepatocellular carcinoma. HBV subviral particles are produced in large excess over virions in infected patients and are the primary source of HBsAg, which is postulated to be important in allowing HBV to chronically persist by interfering with immune function. Nucleic acid polymers (NAPs) have been shown to result in clearance of HBsAg from the blood in pre-clinical and clinical studies. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.02.009DOI Listing
February 2019

Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back.

Prog Neurobiol 2019 Feb 13. Epub 2019 Feb 13.

Headache Science Center, IRCCS C. Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.002DOI Listing
February 2019

Randomized Trial of Miniaturized versus Standard Extracorporeal Circulation in Aortic Valve Surgery.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Dept. of Cardio-Thoracic Surgery, Thoraxcentrum Twente, Medisch Spectrum Twente Hospital, P.O. Box 50 000, 7500 KA Enschede, The Netherlands; Dept. of Cardio-Thoracic Surgery, University Medical Center Groningen, P.O. Box 30 001, 9700 RB Groningen, The Netherlands.

Background: Complications related to extracorporeal circulation remain serious. While a Minimal Invasive Extra Corporeal Circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.019DOI Listing
February 2019

A pediatric case of Staphylococcus lugdunensis-induced infective endocarditis at bovine jugular vein.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of cardiovascular surgery, Mt. Fuji Shizuoka children's hospital, Shizuoka, Japan.

A 2-year-old boy underwent right ventricular outflow tract reconstruction (RVOTR) with a bovine jugular vein graft. He presented with high fever on postoperative day 6. Blood and drainage effusion cultures were all positive for S. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.028DOI Listing
February 2019

Hematology reference intervals for transgender adults on stable hormone therapy.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.

Background: The complete blood count (CBC) is a cornerstone of patient care. Several of the normal values for the components of the CBC differ by sex and, therefore, male-specific and female-specific reference intervals are required to interpret these laboratory results. Transgender individuals are often prescribed hormone therapy to affirm their gender, with resulting serum hormone concentrations similar to those of cisgender individuals. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.011DOI Listing
February 2019

Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Department of Emergency Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 108 Wansong Road, Ruian 325200, Zhejiang Province, China.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is currently known as an acute phase protein and implicated in acute brain injury. Herein, we sought to gauge serum NGAL level in patients after acute (<24 h) spontaneous intracerebral hemorrhage (ICH) and to investigate its relation to neurological outcome.

Methods: Serum NGAL levels were measured in 106 patients and 106 controls. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.009DOI Listing
February 2019

Validity of a rapid and simple fluorometric tripeptidyl peptidase 1 (TPP1) assay using dried blood specimens to diagnose CLN2 disease.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Metabolic Laboratory, Center of Diagnostics, Hamburg, Germany; NCL Clinic, Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany. Electronic address:

Purpose: CLN2 disease is a genetic disorder caused by dysfunction of the lysosomal enzyme tripeptidyl peptidase 1 (TPP1) that belongs to the neuronal ceroid lipofuscinoses (NCL) and leads to epilepsy, dementia, and death in young persons. CLN2 disease has recently become treatable by enzyme replacement, which can only be effective when the disease is diagnosed early. We have investigated the reliability of a test for TPP1 deficiency in dried blood specimens (DBS) to detect CLN2 disease. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.010DOI Listing
February 2019

p38 MAP kinases: plausible diagnostic and prognostic serum protein marker of non small cell lung cancer.

Exp Mol Pathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Introduction: p38 MAPK signaling molecules plays a dual role in cancer, both progression and suppression. Elevated expression of p38α was reported in lung cancer tissue in rat model. Our objective was to explore the concentration of all 4 isoforms of p38MAPK in serum of Non Small Cell Lung Cancer (NSCLC). Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.01.009DOI Listing
February 2019

A dual neutrophil-T cell purification procedure and methodological considerations in studying the effects of estrogen on human Th17 cell differentiation.

J Immunol Methods 2019 Feb 13. Epub 2019 Feb 13.

Program in Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children Research Institute, Canada; Departments of Paediatrics and Physiology, University of Toronto, Canada; Institute of Medical Sciences, University of Toronto, Canada. Electronic address:

New procedures are required to optimize the use of blood samples to study different cell types. The purification of neutrophils and T cells from the same blood sample is not commonly described. We have previously used PolymorphPrep™ (P) or LymphoPrep™ (L) for purifying neutrophils or T cells, respectively. Read More

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http://dx.doi.org/10.1016/j.jim.2019.01.002DOI Listing
February 2019

HTLV prevalence is no longer following the decreasing HIV prevalence - 20 years of retroviral surveillance in Guinea-Bissau, West Africa.

Acta Trop 2019 Feb 13. Epub 2019 Feb 13.

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; Department of Clinical Immunology, Aarhus University Hospital, Denmark.

Background: The HIV-2 and HTLV-1 prevalences in Bissau have followed similar trends in surveys from 1996 and 2006 with HTLV-1 prevalences of 3.6% and 2.3%, respectively. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.015DOI Listing
February 2019

First report of family clusters of Chagas disease seropositive blood donors in Mexico City and their epidemiological relevance.

Acta Trop 2019 Feb 13. Epub 2019 Feb 13.

Hospital de Infectología, Centro Médico "La Raza", Instituto Mexicano del Seguro Social, Mexico.

Background: Chagas disease is an important health problem in Latin America. Relatives of T. cruzi seropositive donors could also test positive in serological assays. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.014DOI Listing
February 2019

Characterization of aspirin esterase activity in health and disease: in vitro and ex vivo studies.

Biochem Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Due to its ability to irreversibly inactivate platelet cyclooxygenase, low-dose aspirin (ASA) is the most widely used antithrombotic agent. Although, studies in specific types of patients with cardiovascular disease (CVD) have shown an incomplete inhibition of platelet's cyclooxygenase, which may increase the variability in drug response. Some aspects of ASA pharmacokinetics (PK) still need further investigation. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.014DOI Listing
February 2019

Association Between Activation of the Programmed Cell Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) Pathway and Pain in Patients with Cancer.

Med Sci Monit 2019 Feb 16;25:1275-1282. Epub 2019 Feb 16.

Department of Palliative Care, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. Read More

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http://dx.doi.org/10.12659/MSM.912632DOI Listing
February 2019

Zika transmission patterns: a meta-review.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Institute of Public Health, University of Heidelberg, Germany.

Objective: To assesses what is known and identify knowledge gaps for Zika virus (ZIKV) transmission patterns.

Methods: Meta-review searching the databases BioSys; Cochrane Infectious Diseases Group Specialised Register and Cochrane Central Register of Controlled Trials; EMBASE; Google Scholar; LILACS; MEDLINE (PubMed); Web of Science; and WHOLIS with the term "ZIKA". Systematic reviews and reviews specifying the search methods and describing potential modes of transmission were eligible for analysis. Read More

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http://dx.doi.org/10.1111/tmi.13216DOI Listing
February 2019

Impact of intertwin interval on short-term neonatal outcomes of the second twin in dichorionic pregnancies with vaginal delivery.

Int J Gynaecol Obstet 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics, Hospital Universitario Materno-Infantil Miguel Servet, Zaragoza, Spain.

Objective: To examine the effect of intertwin interval on umbilical cord pH and Apgar scores of the second twin after vaginal delivery.

Methods: A retrospective study of twin deliveries at a university hospital in Spain between August 2012 and September 2017. Inclusion criteria were vaginal delivery of both twins at 32 gestational weeks or more. Read More

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http://dx.doi.org/10.1002/ijgo.12790DOI Listing
February 2019

The importance of non-technical performance for teams managing postpartum haemorrhage: video review of 99 obstetric teams.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

School of Applied Psychology, University of Applied Sciences and Arts Northwestern Switzerland, Switzerland.

Objective: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage.

Design: Video review - observational study.

Setting: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. Read More

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http://dx.doi.org/10.1111/1471-0528.15655DOI Listing
February 2019

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

Objectives: Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines.

Methods: DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20. Read More

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http://dx.doi.org/10.1002/ajpa.23800DOI Listing
February 2019

Knockdown of Sal-like 4 expression by siRNA induces apoptosis in colorectal cancer.

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Department of Biotechnology, Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Colorectal cancer (CRC) is known as the third most common malignancies among men and women and is also the second leading cause of cancer-related deaths worldwide. It has been indicated that a variety of risk factors are involved in the pathogenesis of CRC. Spalt-like transcription factor 4 (SALL4) is known as a transcription factor that plays an important role in the proliferation of cancerous cells. Read More

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http://dx.doi.org/10.1002/jcb.28433DOI Listing
February 2019

N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.

J Gastroenterol Hepatol 2019 Feb 16. Epub 2019 Feb 16.

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.

Background And Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by acute deterioration of chronic liver disease with excessive inflammation. N-myc and STAT interactor (NMI), an inflammation-mediated protein, involves in various inflammatory related diseases, but the role of NMI in development and prognosis in HBV-ACLF remains to be elucidated.

Methods: Serum NMI from healthy controls (HCs, n=20), chronic hepatitis B (CHB, n=50) patients and HBV-ACLF patients (n=50) were determined using ELISA. Read More

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http://dx.doi.org/10.1111/jgh.14634DOI Listing
February 2019

The skewed frequency of B-cell subpopulation CD19 CD24 CD38 cells in peripheral blood mononuclear cells is correlated with the elevated serum sCD40L in patients with active systemic lupus erythematosus.

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

CD19 CD24 CD38 cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19 CD24 CD38 cells. Changes in B-cell subpopulations and CD19 CD24 CD38 cells have been observed in systemic lupus erythematosus (SLE) patients. Read More

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http://dx.doi.org/10.1002/jcb.28427DOI Listing
February 2019

Longitudinal assessment of cerebral blood flow changes following carotid artery stenting and endarterectomy.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: Carotid artery stenting (CAS) and endarterectomy (CEA) are major treatment strategies for patients with internal carotid artery (ICA) stenosis; however, the dynamic cerebral blood flow (CBF) changes after CAS and CEA remain unclear.

Purpose: This study aimed to monitor consecutive CBF changes at 24-h intervals in patients who underwent CAS and CEA to explore the potential pattern of CBF alternation and compare the effect on CBF changes of different surgical methods.

Methods: Thirty-two patients (28 males and 4 females; age = 63. Read More

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http://dx.doi.org/10.1007/s11547-018-00986-7DOI Listing
February 2019

Comparison of the Extent Classification and the New Complexity Classification of Hepatectomy for Prediction of Surgical Outcomes: a Retrospective Cohort Study.

J Gastrointest Surg 2019 Feb 15. Epub 2019 Feb 15.

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: In predicting the risk for posthepatectomy complications, hepatectomy is traditionally classified into minor or major resection based on the number of resected segments. Recently, a new hepatectomy complexity classification was proposed. This study aimed to compare the value of the traditional and that of the new classification in perioperative outcomes prediction. Read More

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http://dx.doi.org/10.1007/s11605-018-4020-6DOI Listing
February 2019

Recent advances in the pathogenesis of microvascular complications in diabetes.

Arch Pharm Res 2019 Feb 15. Epub 2019 Feb 15.

Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.

Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s12272-019-01130-3DOI Listing
February 2019
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