515 results match your criteria Haberland Syndrome


Determination of Agonistically Acting Autoantibodies to the Adrenergic Beta-1 Receptor by Cellular Bioassay.

Methods Mol Biol 2019 ;1901:95-102

Berlin Cures GmbH, Berlin, Germany.

Agonistically acting autoantibodies directed against the adrenergic beta-1 receptor (beta1-AABs) are a pathogenic factor in diseases of the heart and circulatory system such as dilated cardiomyopathy. Here we describe the detection of such functionally active beta1-AABs from serum samples using spontaneously beating neonatal rat cardiomyocytes, which express the fully functional adrenergic beta-1 receptor coupled with the signal transduction pathway that induces chronotropy. With serum samples added (containing beta1-AABs), an increased positive chronotropic effect is caused that can be blocked by the subsequent addition of specific beta-blockers (abolishing this chronotropic response). Read More

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January 2019

Draft Genome Sequence of Bacillus safensis Strain JG-B5T, Isolated from a Uranium Mining Waste Pile.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Helmholtz Institute Freiberg for Resource Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

Bacillus safensis strain JG-B5T was isolated from soil of the uranium mining waste pile Haberland located near Johanngeorgenstadt, Saxony, Germany. We report here a draft genome sequence (3.7 Mb) of this bacterial strain. Read More

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September 2018

Gender, power, and violence: A systematic review of measures and their association with male perpetration of IPV.

PLoS One 2018 29;13(11):e0207091. Epub 2018 Nov 29.

Population Council, New York, New York, United States of America.

Introduction: Harmful gender norms, views on the acceptability of violence against women, and power inequities in relationships have been explored as key drivers of male perpetration of intimate partner violence (IPV). Yet such antecedents have been inconsistently measured in the empirical literature. This systematic review aimed to identify which measures of gender inequitable norms, views, relations and practices are currently being used in the field, and which are most closely tied with male IPV perpetration. Read More

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November 2018

Dose Optimization of Perfusion-derived Response Assessment in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: Comparison of Volume Perfusion CT and Iodine Concentration.

Acad Radiol 2018 Oct 25. Epub 2018 Oct 25.

Eberhard Karls University, University Hospital Tübingen, Department of Radiology, Diagnostic and Interventional Radiology, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany; University Hospital Basel, University of Basel, Department of Radiology, Petersgraben 4, CH-4031 Basel, Switzerland. Electronic address:

Rationale And Objectives: We assessed the value of iodine concentration (IC) as a perfusion-derived response marker for hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) in comparison with volume perfusion computed tomography (VPCT) parameters.

Materials And Methods: Forty-one HCC lesions in 32 patients examined before and after TACE were analyzed retrospectively. VPCT-parameters were calculated and lesion iodine-maps were computed using subtraction of the baseline and the scan 7 seconds after aortic peak enhancement from the corresponding 80 kVp-VPCT data set. Read More

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October 2018

Dual-energy CT for liver iron quantification in patients with haematological disorders.

Eur Radiol 2018 Nov 7. Epub 2018 Nov 7.

Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076, Tuebingen, Germany.

Objectives: To retrospectively quantify liver iron content in haematological patients suspected of transfusional haemosiderosis using dual-energy CT (DECT) and correlate with serum ferritin levels and estimated quantity of transfused iron.

Methods: One hundred forty-seven consecutive dual-source dual-energy non-contrast chest-CTs in 110 haematologic patients intended primarily for exclusion of pulmonary infection between September 2016 and June 2017 were retrospectively evaluated. Image data was post-processed with a software prototype. Read More

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November 2018
2 Reads

Pseudodidymosis: nevus psiloliparus with aplasia cutis congenita, an initial manifestation of Haberland syndrome.

Int J Dermatol 2018 Dec 20;57(12):e160-e162. Epub 2018 Sep 20.

Department of Dermatology & Venereology, Government Medical College Thrissur, Thrissur, India.

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December 2018
12 Reads

Starting from scratch: implementing outcome measurement in clinical practice.

Ann Palliat Med 2018 Oct 9;7(Suppl 3):S253-S261. Epub 2018 Jul 9.

Department of Palliative Medicine, Munich University Hospital, LMU Munich, Munich, Germany.

Outcome measurement is becoming increasingly important in palliative care both in research as well as clinical care. Regular ongoing assessments in palliative care clinical practice have the potential to enable monitoring of the patient's situation, assess the effectiveness of interventions, assess symptoms accurately and focus on patients' priorities. Implementing routine outcome measurement into clinical practice remains a challenge. Read More

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October 2018
15 Reads

Charge-Transfer Salts of 6,6-Dicyanopentafulvenes: From Topology to Charge Separation in Solution.

Chemistry 2018 Sep 10;24(51):13616-13623. Epub 2018 Aug 10.

Institute of Physical and Theoretical Chemistry, Graz University of Technology, NAWI Graz, Stremayrgasse 9, 8010, Graz, Austria.

6,6-Dicyanopentafulvene derivatives and metallocenes with redox potentials appropriate for forming their radical anions form highly persistent donor-acceptor salts. The charge-transfer salts of 2,3,4,5-tetraphenyl-6,6-dicyanofulvene with cobaltocene (1⋅Cp Co) and 2,3,4,5-tetrakis(triisopropylsilyl)-6,6-dicyanofulvene with decamethylferrocene (2⋅Fc*) have been prepared. The X-ray structures of the two salts, formed as black plates, were obtained and are discussed herein. Read More

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September 2018

Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application.

Brief Bioinform 2018 Jul 31. Epub 2018 Jul 31.

Centre for Cancer Research & Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

There has been an exponential growth in the performance and output of sequencing technologies (omics data) with full genome sequencing now producing gigabases of reads on a daily basis. These data may hold the promise of personalized medicine, leading to routinely available sequencing tests that can guide patient treatment decisions. In the era of high-throughput sequencing (HTS), computational considerations, data governance and clinical translation are the greatest rate-limiting steps. Read More

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Antigen-free control wells in an ELISA set-up for the determination of autoantibodies against G protein-coupled receptors-a requisite for correct data evaluation.

Anal Bioanal Chem 2018 Aug 11;410(21):5101-5105. Epub 2018 Jun 11.

Berlin Cures GmbH, Robert-Rössle-Str. 10, 13125, Berlin, Germany.

First functional acting autoantibodies against G protein-coupled receptors such as the beta2-adrenoceptor in e.g. asthmatic patients have already been discovered in the early 1980s of the last century using assays that show their functional activity. Read More

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August 2018
1 Read

Patterns of missing data in the use of the endometriosis symptom diary.

BMC Womens Health 2018 Jun 8;18(1):88. Epub 2018 Jun 8.

University of Giessen, Giessen, Germany.

Background: Endometriosis is a common, chronic condition in women of reproductive age that is characterized by the presence of functional endometriotic lesions outside the uterus. The Endometriosis Symptom Diary (ESD) is an electronic patient-reported outcome (ePRO) instrument that assesses women's experience of endometriosis symptoms, with pain scored using a 0-10 numeric rating scale. This study investigated patterns of data missing from the ESD in the VALEPRO study. Read More

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June 2018
3 Reads

The MR-Base platform supports systematic causal inference across the human phenome.

Elife 2018 May 30;7. Epub 2018 May 30.

Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base (Read More

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May 2018
7 Reads

Diabetes mellitus in Friedreich Ataxia: A case series of 19 patients from the German-Austrian diabetes mellitus registry.

Diabetes Res Clin Pract 2018 Jul 26;141:229-236. Epub 2018 May 26.

Institute for Epidemiology and medical Biometry, ZIBMT, University of Ulm, Germany; German Center for Diabetes-Research (DZD), Munich-Neuherberg, Germany.

Friedreich ataxia (FRDA) is a multisystem autosomal recessive disease with progressive clinical course involving the neuromuscular and endocrine system. Diabetes mellitus (DM) is one typical non-neurological manifestation, caused by beta cell failure and insulin resistance. Because of its rarity, knowledge on DM in FRDA is limited. Read More

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July 2018
5 Reads

Sulfur Partitioning between Glutathione and Protein Synthesis Determines Plant Growth.

Plant Physiol 2018 Jul 11;177(3):927-937. Epub 2018 May 11.

Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany

Photoautotrophic organisms must efficiently allocate their resources between stress-response pathways and growth-promoting pathways to be successful in a constantly changing environment. In this study, we addressed the coordination of sulfur flux between the biosynthesis of the reactive oxygen species scavenger glutathione (GSH) and protein translation as one example of a central resource allocation switch. We crossed the Arabidopsis () GSH synthesis-depleted cadmium-sensitive mutant, which lacks glutamate cysteine (Cys) ligase, into the sulfite reductase mutant, which suffers from a significantly decreased flux of sulfur into Cys and, consequently, is retarded in growth. Read More

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July 2018
3 Reads

Ub and Down: Ubiquitin Exercise for the Elderly.

Trends Cell Biol 2018 Jul 25;28(7):512-522. Epub 2018 Apr 25.

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany. Electronic address:

Conjugation of ubiquitin onto proteins generates a degradation signal or exerts degradation-independent regulatory functions. Ubiquitylation is governed by the antagonistic action of ubiquitin ligases and deubiquitylating enzymes (DUBs). Several recent publications illustrate a balanced interplay of ligases and DUBs at signaling hubs that are central to longevity and protein homeostasis (proteostasis). Read More

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July 2018
10 Reads

Characterization of Aptamer BC 007 Substance and Product Using Circular Dichroism and Nuclear Magnetic Resonance Spectroscopy.

J Pharm Sci 2018 Aug 18;107(8):2033-2041. Epub 2018 Apr 18.

Berlin Cures GmbH, Robert-Rössle-Str. 10, Laboratory, 13125 Berlin, Germany. Electronic address:

Possible unwanted folding of biopharmaceuticals during manufacturing and storage has resulted in analysis schemes compared to small molecules that include bioanalytical characterization besides chemical characterization. Whether bioanalytical characterization is required for nucleotide-based drugs, may be decided on a case-by-case basis. Nucleotide-based pharmaceuticals, if chemically synthesized, occupy an intermediate position between small-molecule drugs and biologics. Read More

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August 2018
1 Read

Long-term study of tubeless insulin pump therapy compared to multiple daily injections in youth with type 1 diabetes: Data from the German/Austrian DPV registry.

Pediatr Diabetes 2018 Aug 15;19(5):979-984. Epub 2018 Apr 15.

Institute for Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Objective: To examine glycemic control in youth with type 1 diabetes (T1D) who switched from multiple daily injections (MDI) to a tubeless insulin pump (Omnipod Insulin Management System, Insulet Corporation, Billerica, Massachusetts) compared to patients who continued MDI therapy over a 3-year time period.

Research Design And Methods: This retrospective analysis of the German/Austrian Diabetes Patienten Verlaufsdokumentation registry included data from 263 centers and 2529 patients <20 years (n = 660 tubeless insulin pump; n = 1869 MDI) who initiated treatment on a tubeless insulin pump as of January 1, 2013 and had 1 year of data preswitch from MDI and 3 years of data postswitch to a tubeless pump. Outcomes included the change in glycated hemoglobin (HbA1c), insulin dose, and body mass index (BMI) SD score (SDS). Read More

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August 2018
3 Reads

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

Eur J Immunol 2018 May 5;48(5):822-828. Epub 2018 Mar 5.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Eosinophils were reported to serve as an essential component of the plasma cell niche within the bone marrow. As the potential contribution of eosinophils to humoral immunity has remained incompletely understood, we aimed to further characterize their role during antibody responses and to additionally investigate their role in autoimmune disease. Contrary to our expectations and the currently prevailing paradigm, we found that eosinophils are fully dispensable for the survival of murine bone marrow plasma cells and accordingly do not contribute to antibody production and autoantibody-mediated disease. Read More

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May 2018
17 Reads

A Systematic Review of Adolescent Girl Program Implementation in Low- and Middle-Income Countries: Evidence Gaps and Insights.

J Adolesc Health 2018 Jul 9;63(1):18-31. Epub 2018 Feb 9.

PATH, Washington, District of Columbia.

Increasing attention to adolescent girls has generated an abundance of programs and a growing body of research on adolescent girls in low- and middle-income countries. Despite this, questions remain about what implementation approaches in program design are most effective, hindering efficient resource allocation, program scale-up, and replication across settings. To address these questions, we conducted a systematic review to identify lessons learned and gaps in the evidence base. Read More

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July 2018
6 Reads

Difference between beta1-adrenoceptor autoantibodies of human and animal origin-Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology.

PLoS One 2018 9;13(2):e0192615. Epub 2018 Feb 9.

Berlin Cures GmbH, Berlin, Germany.

Cell-based analytics for the detection of the beta1-adrenoceptor autoantibody (beta1-AAB) are functional, yet difficult to handle, and should be replaced by easily applicable, routine lab methods. Endeavors to develop solid-phase-based assays such as ELISA to exploit epitope moieties for trapping autoantibodies are ongoing. These solid-phase-based assays, however, are often unreliable when used with human patient material, in contrast to animal derived autoantibodies. Read More

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April 2018
1 Read

Lipomatosis encefalocraneocutánea: reporte de caso.

Gac Med Mex 2017;153(7):915-918

Servicio de Neurología Pediátrica; Unidad Médica de Alta Especialidad Hospital de Pediatría Dr. Silvestre Freunk Freund, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The encephalocraniocutaneous lipomatosis (ECCL), also known as Fishman or Haberland syndrome, is a rare neurocutaneous syndrome of unknown etiology. Clinically characterized by skin, eye and central nervous system lesions. We present the case of a 7-year-old female who presents to the outpatient clinic of Pediatric Neurology because of the presence of seizures detecting clinical and neuroimaging manifestations compatible with ECCL. Read More

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January 2017
6 Reads

Diagnostic performance of different perfusion algorithms for the detection of angiographical spasm.

J Neuroradiol 2018 Sep 2;45(5):290-294. Epub 2018 Feb 2.

Department of Diagnostic and Interventional Neuroradiology, RWTH Aachen University, 52074 Aachen, Germany; Siemens Healthcare GmbH, 91052 Forchheim, Germany. Electronic address:

Purpose: To assess the diagnostic utility of different perfusion algorithms for the detection of angiographical terial spasm.

Method: During a 2-year period, 45 datasets from 29 patients (54.2±10,75y, 20F) with suspected cerebral vasospasm after aneurysmal subarachnoid hemorrhage were included. Read More

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September 2018
2 Reads

Evaluation of an interdisciplinary palliative care inhouse training for professionals in gynecological oncology.

Arch Gynecol Obstet 2018 Mar 23;297(3):767-773. Epub 2018 Jan 23.

Department of Obstetrics and Gynecology, University Hospital Munich-Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: The aim of this study was to evaluate the effect of a pilot interdisciplinary inhouse training in palliative care (PC) for gynecological oncologists.

Methods: Competencies of participants from a gynecological university department were evaluated taking part in an interdisciplinary PC course in a pre and post design. The multiprofessional course covered basic principles of PC, symptom management and communication taught by PC specialists. Read More

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March 2018
5 Reads

Image Gallery: Juvenile autoimmune pemphigus presenting with diffuse gingival hypertrophy and antibodies against desmocollin 3.

Br J Dermatol 2017 11;177(5):e226

Department of Dermatology, Yale University School of Medicine, 15 York Street, LMP 5040, New Haven, CT, 06510, U.S.A.

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November 2017
3 Reads

Encephalocraniocutaneous Lipomatosis: Haberland Syndrome.

Am J Case Rep 2017 Dec 1;18:1271-1275. Epub 2017 Dec 1.

Department of Neurology, Yeditepe University School of Medicine, Istanbul, Turkey.

BACKGROUND Encephalocraniocutaneous lipomatosis (ECCL) was first announced as a new type of ectomesodermal dysgenesis in 1970 by Haberland and Perou. ECCL was first described in 1970, and approximately 60 cases have been reported since then. The classic triad of ECCL are skin, ocular, and central nervous system involvement, including conditions such as unilateral porencephalic cyst, ipsilateral lipomatous hamartoma of the scalp-eyelids-eye globe, cortical atrophy, cranial asymmetry, developmental delay, seizures, mental retardation, and spasticity of the contralateral limbs. Read More

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December 2017
5 Reads

Preserving protein function through reversible aggregation.

Authors:
Jörg Höhfeld

Nat Cell Biol 2017 Sep;19(10):1142-1144

Institute for Cell Biology, University of Bonn, Ulrich-Haberland-Str. 61a, D-53121 Bonn, Germany.

It is generally accepted that protein function depends on a defined 3D structure, with unfolding and aggregation dealing a final blow to functionality. A study now shows that the regulated exposure of an unstructured region in yeast pyruvate kinase triggers reversible aggregation to preserve protein function under stress. Read More

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September 2017
1 Read

Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort.

Exp Clin Endocrinol Diabetes 2017 Nov 19;125(10):661-668. Epub 2017 Sep 19.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age. Read More

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November 2017
12 Reads
1.760 Impact Factor

Vacuolar ATPase in phago(lyso)some biology.

Int J Med Microbiol 2017 Aug 31. Epub 2017 Aug 31.

Institut für Zellbiologie, Friedrich-Wilhelms-Universität Bonn, Ulrich-Haberland-Str. 61A, D-53121 Bonn, Germany. Electronic address:

Many eukaryotic cells ingest extracellular particles in a process termed phagocytosis which entails the generation of a new intracellular compartment, the phagosome. Phagosomes change their composition over time and this maturation process culminates in their fusion with acidic, hydrolase-rich lysosomes. During the maturation process, degradation and, when applicable, killing of the cargo may ensue. Read More

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August 2017
3 Reads

Haberland Syndrome Associated With Calvarial Exostosis.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4):e141

Department of Radiology, Sankara Nethralaya, Medical Research Foundation, and VRR Scan Centre, Chennai, India.

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August 2018
10 Reads

BAG3-mediated proteostasis at a glance.

J Cell Sci 2017 Sep 14;130(17):2781-2788. Epub 2017 Aug 14.

Institute for Cell Biology, University of Bonn, Ulrich-Haberland-Str. 61a, D-53121 Bonn, Germany

Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis) in stressed cells. Owing to its multi-domain structure, it engages in diverse processes that are crucial for proteome maintenance. Read More

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September 2017
2 Reads

Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy.

Heliyon 2017 Jul 31;3(7):e00362. Epub 2017 Jul 31.

Berlin Cures GmbH, Berlin, Germany.

Background: Autoantibodies specific for the adrenergic beta1-receptor were identified to be an essential factor for the pathogenesis of dilated cardiomyopathy. For the detection of these autoantibodies, a bioassay was developed and has been used, measuring the positive chronotropic effect on spontaneously beating neonatal rat cardiomyocytes. In order to use this bioassay as an analytical tool to monitor the effectiveness of autoantibody neutralizing therapy in a regulated field, there is a need to assess its analytical performance and validate it according to current guidelines. Read More

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July 2017
17 Reads

Encephalocraniocutaneous lipomatosis: A case report with review of literature.

Neuroradiol J 2017 Dec 14;30(6):578-582. Epub 2017 Jul 14.

1 Department of Radiodiagnosis, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.

Encephalocraniocutaneous lipomatosis (ECCL) or Haberland syndrome is an uncommon sporadic neurocutaneous syndrome of unknown origin. The rarity and common ignorance of the condition often makes diagnosis difficult. The hallmark of this syndrome is the triad of skin, ocular and central nervous system (CNS) involvement and includes a long list of combination of conditions. Read More

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December 2017
11 Reads

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.

Cell 2017 04;169(3):470-482.e13

Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. 26, 50931 Cologne, Germany. Electronic address:

Aging is attended by a progressive decline in protein homeostasis (proteostasis), aggravating the risk for protein aggregation diseases. To understand the coordination between proteome imbalance and longevity, we addressed the mechanistic role of the quality-control ubiquitin ligase CHIP, which is a key regulator of proteostasis. We observed that CHIP deficiency leads to increased levels of the insulin receptor (INSR) and reduced lifespan of worms and flies. Read More

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Relationship between low tube voltage (70 kV) and the iodine delivery rate (IDR) in CT angiography: An experimental in-vivo study.

PLoS One 2017 20;12(3):e0173592. Epub 2017 Mar 20.

MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany.

Objective: Very short acquisition times and the use of low-kV protocols in CTA demand modifications in the contrast media (CM) injection regimen. The aim of this study was to optimize the use of CM delivery parameters in thoraco-abdominal CTA in a porcine model.

Materials And Methods: Six pigs (55-68 kg) were examined with a dynamic CTA protocol (454 mm scan length, 2. Read More

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March 2017
14 Reads

Single target sputter deposition of alloy nanoparticles with adjustable composition via a gas aggregation cluster source.

Nanotechnology 2017 Apr 15;28(17):175703. Epub 2017 Mar 15.

Institute for Materials Science-Chair for Multicomponent Materials, Faculty of Engineering, Christian-Albrechts-University of Kiel, Kaiserstraße 2, D-24143 Kiel, Germany.

Alloy nanoparticles with variable compositions add a new dimension to nanoscience and have many applications. Here we suggest a novel approach for the fabrication of variable composition alloy nanoparticles that is based on a Haberland type gas aggregation cluster source with a custom-made multicomponent target for magnetron sputtering. The approach, which was demonstrated here for gold-rich AgAu nanoparticles, combines a narrow nanoparticle size distribution with in operando variation of composition via the gas pressure as well as highly efficient usage of target material. Read More

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April 2017
2 Reads

Mechanical and shape memory properties of porous NiTi alloys manufactured by selective laser melting.

J Mech Behav Biomed Mater 2017 04 31;68:224-231. Epub 2017 Jan 31.

Dynamic and Smart Systems Laboratory, Mechanical Industrial and Manufacturing Engineering Department, The University of Toledo, 2801 W Bancroft St. MS 312 Toledo, OH 43606, USA. Electronic address:

Near equiatomic NiTi shape memory alloys were fabricated in dense and designed porous forms by Selective Laser Melting (SLM) and their mechanical and shape memory properties were systematically characterized. Particularly, the effects of pore morphology on their mechanical responses were investigated. Dense and porous NiTi alloys exhibited good shape memory effect with a recoverable strain of about 5% and functional stability after eight cycles of compression. Read More

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April 2017
6 Reads

Subsequent malignancies among long-term survivors of Hodgkin lymphoma and non-Hodgkin lymphoma: a pooled analysis of German cancer registry data (1990-2012).

Br J Haematol 2017 04 20;177(2):226-242. Epub 2017 Jan 20.

Institute of Transfusion Medicine, Charité - University Hospital Berlin, Campus Virchow Clinic, Berlin, Germany.

The increased risk of subsequent primary malignancies (SPM) in survivors of adult-onset Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) remains a challenging clinical problem worldwide. The German cancer registry database, pooled from 14 federal states, was used to calculate the standardized incidence ratio (SIR) and excess absolute risk (EAR) of SPM in 128 587 patients registered with first primary HL/NHL between 1990 and 2012. Conversely, SIRs were also calculated for a subsequent HL/NHL following other first cancers. Read More

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April 2017
5 Reads
4.710 Impact Factor

Emerging good practices for Translatability Assessment (TA) of Patient-Reported Outcome (PRO) measures.

J Patient Rep Outcomes 2017 21;2(1). Epub 2018 Feb 21.

Mapi Research Trust, 27 rue de la Villette, 69003 Lyon, France.

This paper presents emerging Good Practices for Translatability Assessment (TA) of Patient-Reported Outcome (PRO) Measures. The ISOQOL Translation and Cultural Adaptation Special Interest Group (TCA-SIG) undertook the review of several TA approaches, with the collaboration of organizations who are involved in conducting TA, and members of the TCA-SIG. The effort led to agreement by the writing group on Good Practices for 1) the terminology to be used in referring to translatability process, 2) the best definition of TA, 3) the methodology that is recommended at each step of the process, 4) the persons involved in TA, 5) the timing of assessment, 6) the review criteria for TA, and 7) the recommendations to be made at the end of the TA process. Read More

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February 2018
1 Read

Encephalocraniocutaneous lipomatosis (Haberland syndrome): A rare case report.

Indian Dermatol Online J 2016 Nov-Dec;7(6):523-525

Department of Dermatology, B.J. Medical College, Civil Hospital, Ahmedabad, Gujarat, India.

Haberland syndrome or Fishman syndrome also known as encephalocraniocutaneous lipomatosis (ECCL) is a rare, congenital neurocutaneous disorder. It is characterized by unilateral involvement of skin, eyes and central nervous system. We report the case of a 28-year-old woman who presented with soft lipomatous swelling over right temporal area with nonscarring alopecia of part of frontal and parietal region. Read More

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December 2016
5 Reads

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Biochim Biophys Acta Mol Cell Res 2017 Jan 15;1864(1):62-75. Epub 2016 Oct 15.

Institute for Cell Biology, University of Bonn, Ulrich-Haberland-Str. 61a, 53121 Bonn, Germany. Electronic address:

The cochaperone BAG3 is a central protein homeostasis factor in mechanically strained mammalian cells. It mediates the degradation of unfolded and damaged forms of the actin-crosslinker filamin through chaperone-assisted selective autophagy (CASA). In addition, BAG3 stimulates filamin transcription in order to compensate autophagic disposal and to maintain the actin cytoskeleton under strain. Read More

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January 2017
15 Reads

Simultaneous assessment of hand function and neuromuscular quickness through a static object manipulation task in healthy adults.

Exp Brain Res 2017 01 7;235(1):321-329. Epub 2016 Oct 7.

Department of Health and Exercise Science, Rowan University, 201 Mullica Hill Road, Glassboro, NJ, 08028, USA.

Both hand function [as seen through the coordination between grip force (GF) and load force (LF)] and the ability to produce a submaximal force quickly (i.e., neuromuscular quickness) are two important qualities of motor function that could be seriously affected by the presence of neurological diseases. Read More

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January 2017

Reply to: mitochondrial diabetes in Germany and Austria.

Eur J Pediatr 2016 12 23;175(12):2025-2026. Epub 2016 Sep 23.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, German Center for Diabetes Research (DZD), 89081, Ulm, Germany.

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December 2016
9 Reads

Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy.

Exp Cell Res 2016 Oct 14;348(1):95-105. Epub 2016 Sep 14.

Institute of Physiology II, University Hospital Bonn, Nussallee 11, 53115 Bonn, Germany. Electronic address:

Pressure overload induces cardiac remodeling involving both the contractile machinery and intercalated disks (IDs). Filamin C (FlnC) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adapters localizing in IDs of higher vertebrates. Knockout of the gene encoding Xin (Xirp1) in mice leads to a mild cardiac phenotype with ID mislocalization. Read More

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October 2016
9 Reads

Haberland syndrome: Clinical and neuroimaging findings leading to diagnosis.

Neurologia 2018 Oct 22;33(8):552-554. Epub 2016 Jul 22.

Servicio de Radiodiagnóstico, Hospital Universitario San Cecilio, Granada, España.

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October 2018
5 Reads

Experiences in implementation and publication of operations research interventions: gaps and a way forward.

J Int AIDS Soc 2016 20;19(5 Suppl 4):20842. Epub 2016 Jul 20.

Palladium, Washington DC, USA.

Introduction: According to UNAIDS, the world currently has an adequate collection of proven HIV prevention, treatment and diagnostic tools, which, if scaled up, can lay the foundation for ending the AIDS epidemic. HIV operations research (OR) tests and promotes the use of interventions that can increase the demand for and supply of these tools. However, current publications of OR mainly focus on outcomes, leaving gaps in reporting of intervention characteristics, which are essential to address for the utilization of OR findings. Read More

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September 2017
15 Reads
5.090 Impact Factor

Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors.

Eur J Pharmacol 2016 Oct 1;789:37-45. Epub 2016 Jul 1.

Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany. Electronic address:

The effect of autoantibodies on G-protein coupled receptors in the pathogenesis of diseases, especially of the heart and vascular system, is an increasingly accepted fact today. Dilated cardiomyopathy (DCM) is the most intensively investigated pathological situation of these. With DCM, autoantibodies against the β1-adrenoceptor and the muscarinic M2-receptor have been found in high percentage of investigated patients. Read More

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October 2016
11 Reads

High throughput bioassay for beta1-adrenoceptor autoantibody detection.

Int J Cardiol 2016 Sep 8;219:98-104. Epub 2016 Jun 8.

BerlinCures GmbH, Knesebeckstr.59-61, 10719 Berlin, Germany.

Background: While the involvement of adrenergic beta1-autoantibodies (beta1-AABs) in pathogenesis of cardiomyopathies is well established as are the benefits associated with autoantibody removal by immunoapheresis, the development of drugs neutralizing beta1-AABs in-vivo has been slowed due to a lack of high throughput autoantibody analytics. Highly scalable routine diagnostics involving immobilized binding partners have mostly failed in comparison to the laborious bioassays, which are difficult to scale up, but present the most reliable and sensitive tools for detecting the beta1-autoantibodies.

Methods: A high throughput, image-based assay to measure cardiomyocyte beat rate and contractility was developed and tested for its applicability for detecting adrenergic beta1-autoantibodies. Read More

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September 2016
4 Reads

Encephalocraniocutaneous lipomatosis (Haberland syndrome): A mild case with bilateral cutaneous and ocular involvement.

JAAD Case Rep 2016 Mar 15;2(2):150-2. Epub 2016 Apr 15.

Department of Pediatrics, San Antonio Military Medical Center, San Antonio, Texas.

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March 2016
4 Reads

An Egyptian boy with Haberland syndrome: Case report with observations on the histopathology.

JAAD Case Rep 2015 Nov 28;1(6):384-8. Epub 2015 Oct 28.

Department of Neurology, Faculty of Medicine, Zagazig University, Sharqia, Egypt.

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November 2015
8 Reads

Women's Perceptions and Misperceptions of Male Circumcision: A Mixed Methods Study in Zambia.

PLoS One 2016 3;11(3):e0149517. Epub 2016 Mar 3.

Population Council, Washington DC, United States of America.

Women's perceptions of male circumcision (MC) have implications for behavioral risk compensation, demand, and the impact of MC programs on women's health. This mixed methods study combines data from the first two rounds of a longitudinal study (n = 934) and in-depth interviews with a subsample of respondents (n = 45) between rounds. Most women correctly reported that MC reduces men's risk of HIV (64% R1, 82% R2). Read More

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August 2016
7 Reads