5,097 results match your criteria HPB : the official journal of the International Hepato Pancreato Biliary Association[Journal]


Successful outcome after Pancreaticodoudenectomy in an elderly cirrhotic patient: A case report.

Int J Surg Case Rep 2019 Apr 10;58:18-20. Epub 2019 Apr 10.

Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Electronic address:

Introduction: Cirrhosis is a risk factor for poor outcomes in non-hepatic oncological resections. There are only a handful of cases demonstrating outcomes of pancreaticoduodenectomy (PD) in patients with pancreatic cancer and underlying cirrhosis. Moreover, pushing the limits of PD to elderly cirrhotic patients and demonstrating its safety remains under reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.034DOI Listing

Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
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Evaluating the learning curve for laparoscopic liver resection: a comparative study between standard and learning curve CUSUM.

HPB (Oxford) 2019 Apr 13. Epub 2019 Apr 13.

Department of HPB Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address:

Background: Laparoscopic liver resection (LLR) requires training in both hepatobiliary surgery and advanced laparoscopy. Available data on LLR learning curves are derived from pioneer surgeons. The aims of this study were to evaluate the LLR learning curve for second generation surgeons, and to compare different CUSUM methodology with and without risk adjustment. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.362DOI Listing

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer.

Surg Endosc 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: The laparoscopic approach to liver resection has experienced exponential growth in recent years. However, evidence-based guidelines are needed for its safe future progression. The main aim of our study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for colorectal liver metastases (CRLM). Read More

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http://dx.doi.org/10.1007/s00464-019-06774-2DOI Listing

Nomogram for predicting postoperative pancreatic fistula.

HPB (Oxford) 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, Seoul National University College of Medicine, Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.

Background: Previous studies analyzed risk factors for postoperative pancreatic fistula (POPF) and developed risk prediction tool using scoring system. However, no study has built a nomogram based on individual risk factors. This study aimed to evaluate individual risks of POPF and propose a nomogram for predicting POPF. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.351DOI Listing

Successful domino liver transplantation using a graft from a controlled donation after circulatory death (Maastricht III).

Cir Esp 2019 Apr 10. Epub 2019 Apr 10.

Unidad de Cirugía HPB y Trasplante Hepático, Hospital Universitario Virgen del Rocío, Sevilla, España.

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http://dx.doi.org/10.1016/j.ciresp.2019.01.013DOI Listing

National survey on Pancreatic Surgery Units.

Cir Esp 2019 Apr 10. Epub 2019 Apr 10.

Unidad de Cirugía Hepatobiliopancreática, Servicio de Cirugía General y Aparato Digestivo, Hospital Virgen del Rocío, Sevilla, España; Sección Hepatobiliopancreática (HPB) de la Asociación Española de Cirujanos.

Introduction: The technical, human, scientific and treatment characteristics of the Units that manage complex pathologies have not been studied in depth.

Methods: Multi-institutional descriptive study (survey) developed jointly by the Hepatobiliary-Pancreatic Division of the Spanish Association of Surgeons and the Spanish Chapter of the IHPBA (International Hepatopancreatobiliary Association) on the characteristics of the Units where pancreatic surgery is performed in Spain.

Results: 82 surveys were sent. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0009739X193006
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http://dx.doi.org/10.1016/j.ciresp.2019.02.007DOI Listing
April 2019
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Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies.

Sci Rep 2019 Apr 12;9(1):5984. Epub 2019 Apr 12.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Tissue-resident memory T (T) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- T cells. The origin and functional characteristics of T cells in the renal allograft are largely unknown. To determine these features we studied T cells in transplant nephrectomies. Read More

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http://dx.doi.org/10.1038/s41598-019-42401-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461670PMC

KRAS mutational status impacts pathologic response to pre-hepatectomy chemotherapy: a study from the International Genetic Consortium for Liver Metastases.

HPB (Oxford) 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA. Electronic address:

Background: A major response to pre-hepatectomy chemotherapy has been associated with improved survival in patients who undergo resection of colorectal liver metastases (CRLM). However, the role of tumor biology, as exemplified by overall and codon-specific KRAS mutational status, in predicting response to chemotherapy is not well defined.

Methods: Pathologic response was characterized as minor or major depending on the percentage of remnant viable cells (>50% vs <50%, respectively). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X193049
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http://dx.doi.org/10.1016/j.hpb.2019.03.368DOI Listing
April 2019
2 Reads

The inflammatory response after laparoscopic and open pancreatoduodenectomy and the association with complications in a multicenter randomized controlled trial.

HPB (Oxford) 2019 Apr 8. Epub 2019 Apr 8.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands. Electronic address:

Background: The systemic inflammatory response seen after surgery seems to be related to postoperative complications. A reduction of the inflammatory response through minimally invasive surgery might therefore be the mechanism via which postoperative outcome could be improved. The aim of this study was to investigate if postoperative inflammatory markers differed between laparoscopic (LPD) and open pancreatoduodenectomy (OPD) and if there was a relationship between inflammatory markers and the occurrence of postoperative complications. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.353DOI Listing
April 2019
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Association of binge drinking in adolescence and early adulthood with high blood pressure: findings from the National Longitudinal Study of Adolescent to Adult Health (1994-2008).

J Epidemiol Community Health 2019 Apr 10. Epub 2019 Apr 10.

Brown School at Washington University in St. Louis, St. Louis, Missouri, United States.

Background: An investigation of the risk of high blood pressure (HBP) associated with heavy alcohol consumption in adolescence and early adulthood is lacking. Therefore, we aimed to investigate the association between binge drinking from adolescence to early adulthood and the risk of HBP in early adulthood.

Methods: We applied logistic regression to publicly available, population-representative data from waves I (1994-1995; ages 12-18) and IV (2007-2008; ages 24-32) of the National Longitudinal Study of Adolescent to Adult Health (n=5114) to determine whether past 12-month binge drinking in adolescence (wave I) and early adulthood (wave IV) was associated with HBP in early adulthood after adjusting for covariates, including smoking and body mass index. Read More

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http://jech.bmj.com/lookup/doi/10.1136/jech-2018-211594
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http://dx.doi.org/10.1136/jech-2018-211594DOI Listing
April 2019
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Detailed reporting is of utmost importance when a controversial treatment is being evaluated.

HPB (Oxford) 2019 Apr 6. Epub 2019 Apr 6.

Department of Surgery and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1016/j.hpb.2019.03.367DOI Listing

Combined liver-kidney transplantation; two for the price of one?

Transpl Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands.

In 1983 the first combined liver and kidney transplantation (CLKT) was performed by Margreiter et al and the first CLKT from a living related donor was carried out in Turkey in 1992. The indications for CLKT can be divided into three categories: I) end-stage liver disease with chronic kidney failure, II) end-stage liver disease with acute kidney failure, and III) metabolic disorders. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/tri.13438DOI Listing
April 2019
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Postoperative nutritional benefits of proximal parenchymal pancreatectomy for low-grade malignant lesions in the pancreatic head.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Department of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Outcomes of proximal parenchymal pancreatectomy (PPP) as compared to pancreatoduodenectomy (PD) have not been reported. The aim of this study was to describe the short- and long-term outcomes of patients with low-grade pancreatic head lesions who underwent PPP or PD.

Methods: Patients who underwent PPP or PD for low-grade lesions between 2009 and 2017 were included. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.359DOI Listing
April 2019
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Robotic versus conventional laparoscopic distal pancreatic resection: a systematic review and meta-analysis.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Department of Hepatobiliary, Pancreatic and Transplant Surgery, Academic Department of Surgery, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, UK.

Background: Robotic surgery offers theoretical advantages to conventional laparoscopic surgery including improved instrument dexterity, 3D visualization and better ergonomics. This review aimed to determine if these theoretical advantages translate into improved patient outcomes in patients undergoing distal pancreatectomy through laparoscopic (LDP) or robotic (RDP) approaches.

Method: A systematic literature search was conducted for studies reporting minimally invasive surgery for distal pancreatectomy. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.020DOI Listing

Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

The Intervention Center, Oslo University Hospital - Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Norway; Department of HPB Surgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

Background: Laparoscopic liver resection in the posterosuperior segments is technically challenging. This study aimed to compare the perioperative outcomes for laparoscopic and open resection of colorectal liver metastases located in the posterosuperior segments.

Methods: This was a subgroup analysis of the OSLO-COMET randomized controlled trial, where 280 patients were randomly assigned to open or laparoscopic parenchyma-sparing liver resections of colorectal metastases. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.358DOI Listing

Is progression in the future liver remnant a contraindication for second-stage hepatectomy?

HPB (Oxford) 2019 Apr 6. Epub 2019 Apr 6.

Aix-Marseille University, Institut Paoli-Calmettes, Department of Surgery, CNRS, Inserm, CRCM, Marseille, France.

Background: Two-stage hepatectomy (TSH) strategy is used to treat patients with bilobar colorectal liver metastasis (CLM). However, many patients do not undergo the second hepatectomy owing to disease progression in the future liver remnant (FLR) after portal vein embolization (PVE). This study aimed to assess the impact of disease progression in the FLRs of patients who completed the first hepatectomy. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.357DOI Listing

Diagnosis and management of postpancreatectomy hemorrhage: a systematic review and meta-analysis.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Department of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center Utrecht, St Antonius Hospital Nieuwegein, the Netherlands. Electronic address:

Background: Postpancreatectomy hemorrhage is a potentially lethal complication after pancreatic resection. The objective of this systematic review is to provide insight in the current status of incidence, detection, management and clinical outcomes of late postpancreatectomy hemorrhage.

Methods: A systematic search was conducted on the literature from February 2007 to July 2018 in PubMed, Embase and the Cochrane library. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.011DOI Listing

Liver transplantation with a normothermic machine preserved fatty nonagenarian liver: A case report.

Int J Surg Case Rep 2019 Mar 30;57:163-166. Epub 2019 Mar 30.

Department of Surgery, HPB and Transplant Unit, Tor Vergata University of Rome, Italy.

Introduction: The use of organs from expanded criteria donors for Liver Transplantation (LT) represents a major challenge. In the current era of Normothermic Machine Perfusion (NMP), donor age boundaries are often overcome and may contribute to reduce the gap between supply and demand of organs suitable for transplantation. We report on a unique case of nonagenarian liver successfully transplanted after NMP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193015
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http://dx.doi.org/10.1016/j.ijscr.2019.03.033DOI Listing
March 2019
2 Reads

Use of a modified Delphi approach to develop research priorities in HPB surgery across the United Kingdom.

HPB (Oxford) 2019 Apr 4. Epub 2019 Apr 4.

HPB Surgical Unit, Mater Hospital, Belfast BT14 6AB, UK.

Background: Research prioritisation can help identify clinically relevant questions and encourage high-quality, patient-centred research. Delphi methodology aims to develop consensus opinion within a group of experts, with recent Delphi projects helping to define the research agenda and funding within several medical and surgical specialties.

Methods: All members of the Association of Upper Gastrointestinal Surgeons (AUGIS) were asked to submit clinical research questions using an online survey (Phase 1). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.352DOI Listing

Prediction of Discharge Destination Following Major Hepatectomy.

HPB (Oxford) 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Surgery, VA Boston Healthcare System, West Roxbury, MA, USA.

Background: Anatomic hepatectomies can be associated with complicated post-operative recoveries, often with discharge to post-acute care facilities. This study identifies preoperative and intraoperative factors associated with increased risk for non-home discharge destination after major hepatectomy.

Methods: Patients undergoing major hepatectomy were identified in the NSQIP Targeted Hepatectomy Dataset (2014-2016). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.354DOI Listing
April 2019
1 Read

Peer review of mortality after pancreaticoduodenectomy in Australia.

HPB (Oxford) 2019 Apr 4. Epub 2019 Apr 4.

Discipline of Surgery, University of Adelaide, The Queen Elizabeth Hospital, Australia.

Background: The data within the Australian and New Zealand Audit of Surgical Mortality (ANZASM) provides a unique opportunity to consider the contributing factors to perioperative deaths as determined by peer review. Consideration of the factors contributing to mortality after pancreaticoduodenectomy (PD) can provide greater insight into how deaths can be prevented.

Methods: ANZASM data from 1 January 2010 to 30 Jun 2017 was reviewed and all deaths following PD were selected for analysis. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.356DOI Listing
April 2019
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Prognostic relevance of preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 in a multicenter subset analysis of 179 patients with distal cholangiocarcinoma.

HPB (Oxford) 2019 Apr 5. Epub 2019 Apr 5.

Dept. for Visceral, Thoracic and Vascular Surgery at the University Hospital, Technical University Dresden, Dresden, Germany. Electronic address:

Background: Distal cholangiocarcinoma (DCC) is a rare malignancy and validated prognostic markers remain scarce. We aimed to evaluate the role of serum CA19-9 as a potential biomarker in DCC.

Methods: Patients operated for DCC at 6 high-volume surgical centers from 1994 to 2015 were identified from prospectively maintained databases. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.03.363DOI Listing
April 2019
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Occurrence of human pathogenic bacteria carrying antibiotic resistance genes revealed by metagenomic approach: A case study from an aquatic environment.

J Environ Sci (China) 2019 Jun 14;80:248-256. Epub 2019 Jan 14.

State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

Antibiotic resistance genes (ARGs), human pathogenic bacteria (HPB), and HPB carrying ARGs are public issues that pose a high risk to aquatic environments and public health. Their diversity and abundance in water, intestine, and sediments of shrimp culture pond were investigated using metagenomic approach. A total of 19 classes of ARGs, 52 HPB species, and 7 species of HPB carrying ARGs were found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10010742183158
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http://dx.doi.org/10.1016/j.jes.2019.01.001DOI Listing
June 2019
2 Reads
2.002 Impact Factor

Short- and Long-Term Outcomes of Liver Resection for Intrahepatic Cholangiocarcinoma Associated with the Metabolic Syndrome.

World J Surg 2019 Apr 4. Epub 2019 Apr 4.

Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Background: While the metabolic syndrome (MS) is being recognized as an important risk factor for intrahepatic cholangiocarcinoma (ICC), the outcomes of liver resection in this context remain poorly described. This study aims to report the short- and long-term results of hepatectomy for patients with MS as risk factor for the development of ICC (MS+).

Methods: All patients undergoing hepatectomy for ICC between 2000 and 2016 at a single center were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00268-019-04996-yDOI Listing
April 2019
3 Reads

Does the Anatomy of the Transected Pancreatic Neck Influence Post Whipple's Operation Pancreatic Fistula?

Indian J Surg Oncol 2019 Mar 11;10(1):31-36. Epub 2018 May 11.

Department of Surgical Gastroenterology and HPB Surgery, Jagjivan Ram Hospital, Maratha MandirLane, Mumbai Central, Mumbai, 400008 India.

Few studies correlate anatomical parameters of the transected pancreatic neck to occurrence of the dangerous complication-post Whipple's pancreaticoduodenectomy pancreatic fistula. To evaluate the correlation between anatomical details of the transected neck of the pancreas and post-operative pancreatic fistula (POPF) following Whipple's pancreaticoduodenectomy. Observational study. Read More

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http://dx.doi.org/10.1007/s13193-018-0747-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414556PMC

Risk and Predictors of Postoperative Morbidity and Mortality After Pancreaticoduodenectomy for Pancreatic Neuroendocrine Neoplasms: A Comparative Study With Pancreatic Ductal Adenocarcinoma.

Pancreas 2019 04;48(4):504-509

Department of HPB and Liver Transplant Surgery, Royal Free Hospital, NHS Foundation Trust, London, United Kingdom.

Objectives: Pancreaticoduodenectomy (PD) is associated with a high risk of postoperative complications and mortality. The aim of this study was to compare postoperative morbidity after PD in patients undergoing resections for pancreatic neuroendocrine neoplasms (PanNENs) with patients undergoing the same resection for pancreatic ductal adenocarcinoma (PDAC).

Methods: Data of 566 patients from 3 European tertiary referral centers between 1998 and 2014 were considered. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001273DOI Listing

Drain Management Following Distal Pancreatectomy: Characterization of Contemporary Practice and Impact of Early Removal.

Ann Surg 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.

MINI: Early drain removal has yet to be explored following distal pancreatectomy. Following analysis of ACS-NSQIP data, early removal demonstrated significantly better outcomes when compared to late removal and drain omission. Multivariable analysis revealed early removal had reduced odds for pancreatic fistula and death or serious morbidity compared to drain omission, while late drain removal conversely displayed increased odds. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003205DOI Listing
January 2019

Drain or No Drain Following Pancreaticoduodenectomy: The Unsolved Dilemma.

Scand J Surg 2019 Mar 31:1457496919840960. Epub 2019 Mar 31.

Liver Transplantation and HPB Unit, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Background And Aims:: There is no consensus regarding the routine placement of intra-abdominal drains after pancreaticoduodenectomy. We aim to determine the effects of intraperitoneal drain placement during pancreaticoduodenectomy on 30-day postoperative morbidity and mortality.

Methods:: Patients who underwent pancreaticoduodenectomy for pancreatic tumors were identified from the 2014-2015 American College of Surgeons-National Surgical Quality Improvement Program Database. Read More

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http://dx.doi.org/10.1177/1457496919840960DOI Listing
March 2019
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Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review.

HPB (Oxford) 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands.

Background: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking.

Methods: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985-April 2018). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.022DOI Listing
March 2019
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Implementation and first results of a mandatory, nationwide audit on liver surgery.

HPB (Oxford) 2019 Mar 26. Epub 2019 Mar 26.

University Medical Centre Groningen, Department of Surgery, Groningen, the Netherlands.

Background: The Dutch Hepato Biliary Audit (DHBA) was initiated in 2013 to assess the national quality of liver surgery. This study aimed to describe the initiation and implementation of this audit along with an overview of the results and future perspectives.

Methods: Registry of patients undergoing liver surgery for all primary and secondary liver tumors in the DHBA is mandatory. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.021DOI Listing
March 2019
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Combined hepatic and portal vein embolization as preparation for major hepatectomy: a systematic review.

HPB (Oxford) 2019 Mar 26. Epub 2019 Mar 26.

Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Henri Mondor Hospital, Créteil, France; Department of General Surgery and Transplantation, Sheba Medical Center, Faculty of Medicine, Tel Aviv University, Israel; Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France. Electronic address:

Background: Some patients remain deemed unsuitable for resection after portal vein embolization (PVE) because of insufficient hypertrophy of the future remnant liver (FRL). Hepatic and portal vein embolization (HPVE) has been shown to induce hypertrophy of the FRL. The aim of this study was to provide a systematic review of the available literature on HPVE as preparation for major hepatectomy. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.023DOI Listing

Regarding the relationship between mild pancreatitis and difficulty of cholecystectomy.

HPB (Oxford) 2019 Mar 26. Epub 2019 Mar 26.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.hpb.2019.02.010DOI Listing

The association between preoperative physical functioning and short-term postoperative outcomes: a cohort study of patients undergoing elective hepatic resection.

HPB (Oxford) 2019 Mar 26. Epub 2019 Mar 26.

Department of Epidemiology, Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands; Top Sector Life Sciences and Health (Health∼Holland), P.O. Box 93035, 2509 AA, The Hague, the Netherlands.

Background: This study evaluated the association between practical performance-based indices of preoperative physical functioning and short-term postoperative outcomes in patients undergoing hepatic resection.

Method: Preoperative characteristics and results of practical performance-based tests of physical functioning were analyzed concerning the effect on postoperative outcomes (recovery of physical functioning, non-surgical complications, and length of hospital stay) using univariable and multivariable logistic regression.

Results: Perioperative data of 96 patients showed that besides the conventional risk-factors (American Society of Anesthesiologists grade III and BMI), lower absolute steep ramp test performance (in watts; OR 0. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.009DOI Listing

New scoring system for resectable hepatocellular carcinoma with a maximum tumor size of ≤5 cm based on preoperative tumor factors.

HPB (Oxford) 2019 Mar 25. Epub 2019 Mar 25.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea. Electronic address:

Background: The aim of this study was to establish a new scoring system for hepatocellular carcinoma (HCC) that can be used to predict the postoperative prognosis of HCC patients.

Methods: A total of 359 HCC patients who underwent hepatectomy were included in this study. All eligible patients were randomly allocated to derivation cohort or validation cohort samples. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.018DOI Listing

A systematic review of the effectiveness of adjuvant therapy for patients with gallbladder cancer.

HPB (Oxford) 2019 Mar 25. Epub 2019 Mar 25.

PhD Program in Medical Sciences, Universidad de La Frontera, Chile.

Background: Equipoise exists regarding the benefit of adjuvant therapy (AT) in patients with gallbladder cancer (GBC). The aim of this study was to critically review the available evidence for the effectiveness of AT in patients with GBC following surgery with curative intent.

Methods: A systematic review was performed. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.019DOI Listing
March 2019
4 Reads

Metabolomic profiling highlights the metabolic bases of acute-on-chronic and post-hepatectomy liver failure.

HPB (Oxford) 2019 Mar 23. Epub 2019 Mar 23.

Laboratoire ICube, UMR7357, University of Strasbourg, France; Biophysics and Nuclear Medicine Department, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, France.

Background: Posthepatectomy liver failure (PHLF) is the main limitation to extending liver resection but its pathophysiology is not yet fully understood. The aim of the study was to describe the metabolic adaptations that occur with PHLF.

Methods: A retrospective study of 82 patients using nuclear magnetic resonance metabolomics to identify and quantify intra-hepatic metabolites was performed. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.008DOI Listing
March 2019
1 Read

Short term outcomes and unintended benefits of establishing a HPB program at a university-affiliated community hospital.

Am J Surg 2019 Mar 15. Epub 2019 Mar 15.

Western Michigan University Homer Stryker M.D. School of Medicine, Department of General Surgery, 1000 Oakland Dr, Kalamazoo, MI, 49008, USA; Western Michigan Cancer Center, 200 N Park St, Kalamazoo, MI, 49007, USA. Electronic address:

Background: In hepato-pancreato-biliary (HPB) surgery higher volumes are associated with improved outcomes; however, there are limitations to regionalization. Here we report our experience establishing multidisciplinary HPB program at a university-affiliated community hospital.

Methods: This is a retrospective review of patients who underwent HPB surgery between 2015 and 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029610183050
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http://dx.doi.org/10.1016/j.amjsurg.2019.03.015DOI Listing
March 2019
2 Reads
2.291 Impact Factor

Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) as an outpatient procedure.

Pleura Peritoneum 2018 Dec 27;3(4):20180128. Epub 2018 Nov 27.

Odense PIPAC Center & Odense Pancreas Center (OPAC), Odense Patient data explorative Network (OPEN), Odense University Hospital, Odense, Denmark.

Background: Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a drug-delivery method for patients with peritoneal metastasis (PM). The study objective was to investigate whether PIPAC is possible in an outpatient setting.

Methods: Data was extracted from the prospective PIPAC-OPC2 study (ClinicalTrials. Read More

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http://dx.doi.org/10.1515/pp-2018-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405001PMC
December 2018

Treatment of peritoneal carcinomatosis with Pressurized IntraPeritoneal Aerosol Chemotherapy - PIPAC-OPC2.

Pleura Peritoneum 2018 Jun 9;3(2):20180108. Epub 2018 Jun 9.

Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) HPB and Upper GI Section, Department of Surgery, Odense University Hospital, Odense, Denmark.

Background: Peritoneal carcinomatosis (PC) is a common endpoint in both gastrointestinal and non-gastrointestinal cancers, and PC is treated as other systemic metastases - unfortunately with disappointing results and considerable side-effects. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a new method of applying traditional chemotherapy, and preliminary data indicate that PIPAC is safe, able to stabilize or improve quality of life, and can induce an objectively measurable reduction in disease burden in PC.

Methods: PIPAC-OPC2 is a prospectively controlled Phase II, single center, one-arm, open-label clinical trial investigating the treatment effect of PIPAC in patients with histological or cytological proven PC from gastrointestinal, ovarian or primary peritoneal cancer. Read More

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http://dx.doi.org/10.1515/pp-2018-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404994PMC
June 2018
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Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in resected high-risk colon cancer patients - study protocol for the PIPAC-OPC3 Trial. A prospective, controlled phase 2 Study.

Pleura Peritoneum 2018 Jun 12;3(2):20180107. Epub 2018 Jun 12.

Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC), HPB and Upper GI Section, Department of Surgery, Odense University Hospital, Odense, Denmark.

Background: Peritoneal metastasis (PM) is the second most common site of recurrence in colon cancer (CC) patients and accounts for approximately one-third of all recurrences. Patients with T4 or intraperitoneal perforated colon cancers have an increased risk of developing PM, and since manifest PM is difficult to treat, high-risk patients should be offered prophylactic treatment. Here, we propose a study of adjuvant oxaliplatin administered as pressurized intraperitoneal aerosol chemotherapy (PIPAC OX) in patients with high-risk colon cancer (T4, perforated tumors, ovarian metastasis). Read More

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http://dx.doi.org/10.1515/pp-2018-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404996PMC
June 2018
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Braden scale for pressure ulcer risk predicts rehabilitation placement after pancreatic resection: is this accurate?

HPB (Oxford) 2019 Mar 22. Epub 2019 Mar 22.

School of Nursing, Nantong University, Nantong city, Jiangsu province, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X193010
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http://dx.doi.org/10.1016/j.hpb.2019.02.015DOI Listing
March 2019
2 Reads

Defining the practice of distal pancreatectomy around the world.

HPB (Oxford) 2019 Mar 22. Epub 2019 Mar 22.

Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Background: Best management practices for distal pancreatectomy (DP) have not been conclusively defined. The aim of this study was to analyze the practice of DP worldwide and to compare surgeons' behavior with the best available evidence.

Methods: A survey assessing management approaches for DP was distributed worldwide, in eight native-language translations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X193010
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http://dx.doi.org/10.1016/j.hpb.2019.02.016DOI Listing
March 2019
6 Reads

Dilatation of the main pancreatic duct as first manifestation of small pancreatic ductal adenocarcinomas detected in a hereditary pancreatic cancer surveillance program.

HPB (Oxford) 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands.

Background: MRI surveillance in a cohort of CDKN2A-p16-Leiden mutation carriers with a 20% lifetime risk of PDAC led to increased resection rates and improved survival. Patients with screen-detected PDAC were evaluated for main pancreatic duct (MPD) abnormalities in this retrospective review.

Methods: Since 2000 annual MRI and optional EUS was performed in mutation carriers. Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.013DOI Listing

Simultaneous voltammetric immunodetection of alpha-fetoprotein and glypican-3 using a glassy carbon electrode modified with magnetite-conjugated dendrimers.

Mikrochim Acta 2019 Mar 23;186(4):255. Epub 2019 Mar 23.

SVKM's NMIMS, Sunandan Divatia School of Science, Department of Chemistry, Deemed-to-be University, Vile Parle (west), Mumbai, 400056, India.

The authors describe an electrochemical immunoassay for simultaneous determination of alpha-fetoprotein (AFP) and glypican-3 (GPC-3) which are important biomarkers for early detection of hepatocellular carcinoma (HCC). Magnetite (FeO) nanoparticles (NPs) were decorated with hyperbranched amino functionalized dendrimers. The modified NPs were coupled to the antibodies against AFP and GPC-3. Read More

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http://link.springer.com/10.1007/s00604-019-3354-4
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http://dx.doi.org/10.1007/s00604-019-3354-4DOI Listing
March 2019
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Validation of early drain removal after pancreatoduodenectomy based on modified fistula risk score stratification: a population-based assessment.

HPB (Oxford) 2019 Mar 18. Epub 2019 Mar 18.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background: Recent studies on postoperative pancreatic fistula (POPF) prevention following pancreatoduodenectomy (PD) have proposed omission of perioperative drains for negligible/low-risk patients and early drain removal (≤POD3) for intermediate/high-risk patients with POD1 drain amylase levels of ≤5000 U/L, though this has not been validated using a nationwide cohort.

Methods: The ACS-NSQIP targeted pancreatectomy database from 2014 to 2016 was queried to identify patients who underwent PD. Patients with POD1 drain amylase levels of ≤5000 U/L were initially stratified as negligible/low- or intermediate/high-risk based on a previously validated modified fistula risk score (mFRS). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.002DOI Listing

Three different polymorphisms of the DPYD gene associated with severe toxicity following administration of 5-FU: a case report.

J Med Case Rep 2019 Mar 22;13(1):76. Epub 2019 Mar 22.

Department of Surgery, HPB and Liver Transplant Unit, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.

Background: Dihydropyrimidine dehydrogenase deficiency secondary to polymorphisms in the DPYD gene can lead to significant toxicity associated with the administration of fluoropyrimidine chemotherapy.

Case Presentation: We report a case of a 59-year-old Lebanese woman with metastatic pancreatic cancer who received FOLFIRINOX therapy and developed severe 5-fluorouracil toxicity after a single cycle. The entire DPYD gene was sequenced, and the patient was found to be heterozygous for three different polymorphisms that have reportedly been associated with dihydropyrimidine dehydrogenase deficiency. Read More

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http://dx.doi.org/10.1186/s13256-019-2013-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429833PMC
March 2019
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Patient characteristics and clinical outcomes following initial surgical intervention for MEN1 associated pancreatic neuroendocrine tumours: A systematic review and exploratory meta-analysis of the literature.

Pancreatology 2019 Apr 12;19(3):462-471. Epub 2019 Mar 12.

Department of Surgery, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; HPB Unit, Department of General Surgery, Auckland City Hospital, Auckland, New Zealand. Electronic address:

Background: This systematic review aimed to define the outcomes of different pancreatic resection procedures for multiple endocrine neoplasia type 1 (MEN1) associated pancreatic neuroendocrine neoplasms (pNENs).

Methods: A search of PubMed, MEDLINE and SCOPUS databases were performed in accordance with PRISMA guidelines.

Results: Twenty-seven studies including 533 patients undergoing initial pancreatic resection for MEN1 associated pNENs were included in this systematic review. Read More

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http://dx.doi.org/10.1016/j.pan.2019.03.002DOI Listing
April 2019
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Rapid but not Harmful: Functional Evaluation With Hepatobiliary Scintigraphy After Accelerated Liver Regeneration Techniques.

Ann Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Medical and Surgical Sciences, General Surgery and Transplantation Unit, University of Bologna, Bologna, Italy Department of Surgery, Division of HPB Surgery, Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina Department of Medical and Surgical Sciences, General Surgery and Transplantation Unit, University of Bologna, Bologna, Italy Department of Medical and Surgical Sciences, General Surgery and Transplantation Unit, University of Bologna, Bologna, Italy Department of Surgery, Division of HPB Surgery, Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1097/SLA.0000000000003184DOI Listing
January 2019