6 results match your criteria HIV-1 Associated Opportunistic Infections - CNS Cryptococcosis

  • Page 1 of 1

HIV-associated neurological disorders: a guide to pharmacotherapy.

CNS Drugs 2012 Feb;26(2):123-34

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287-7613, USA.

In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorder (HAND) continues to be a common and significant morbidity among individuals infected with HIV. The term HAND encompasses a spectrum of progressively severe CNS involvement, ranging from asymptomatic neurocognitive impairment and minor neurocognitive disorder through to the most severe form of HIV-associated dementia (HAD). While the incidence of HAD has declined significantly with HAART, the milder forms of HAND persist. Read More

View Article and Full-Text PDF
February 2012

Cerebrospinal fluid levels of chemokines in HIV infected patients with and without opportunistic infection of the central nervous system.

J Neurol Sci 2009 Dec 25;287(1-2):79-83. Epub 2009 Sep 25.

Neurology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Chemokines are chemoattractant cytokines involved in the immune response of a wide variety of diseases. There are few studies assessing their role in opportunistic infections in HIV-infected patients. In this study, we measured CC and CXC chemokines in cerebrospinal fluid (CSF) samples obtained from 40 HIV-infected patients with or without opportunistic infections of the central nervous system (CNS). Read More

View Article and Full-Text PDF
December 2009

HIV disorders of the brain: pathology and pathogenesis.

Front Biosci 2006 Jan 1;11:718-32. Epub 2006 Jan 1.

Center for Neurovirology and Cancer Biology, Laboratory of Neuropathology and Molecular Pathology, Temple University, Philadelphia, Pennsylvania 19122, USA.

Infection with HIV-1 has spread exponentially in recent years to reach alarming proportions. It is estimated than more than 33 million adults and 1.3 million children are infected worldwide. Read More

View Article and Full-Text PDF
January 2006

Detection of HIV RNA levels in intraocular and cerebrospinal fluids in patients with AIDS-related cryptococcosis.

Ophthalmologica 2005 Mar-Apr;219(2):101-6

Department of Ophthalmology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.

The objective of the present study was to evaluate human immunodeficiency virus (HIV) levels in the aqueous humor and vitreous fluid in patients with and those without ocular involvement due to AIDS-related cryptococcosis. We also assessed whether cryptococcosis infection in the central nervous system (CNS) was associated with elevated HIV levels in the cerebrospinal fluid (CSF). From 1993 to 2003, we obtained 16 CSF samples from 9 AIDS patients with cryptococcal meningitis and 7 AIDS patients without CNS opportunistic infection. Read More

View Article and Full-Text PDF

The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations.

Ann Neurol 2004 May;55(5):687-94

Clinic of Infectious Diseases, San Raffaele Scientific Institute, University of Milan, Italy.

The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in extracellular matrix degradation and cell migration in the central nervous system (CNS). To investigate the role of the uPA/uPAR system in the pathophysiology of acquired immunodeficiency syndrome dementia complex (ADC), we measured soluble uPAR (suPAR) levels in cerebrospinal fluid (CSF) and plasma from human immunodeficiency virus (HIV)-1-infected patients and controls. CSF suPAR levels were significantly higher in HIV-1-infected patients than in controls and in patients with ADC or opportunistic CNS infections (CNS-OIs) than in neurologically asymptomatic patients, irrespective of HIV-1 disease stage. Read More

View Article and Full-Text PDF

Increased activity of matrix metalloproteinases in the cerebrospinal fluid of patients with HIV-associated neurological diseases.

J Neurovirol 2000 Apr;6(2):156-63

Department of Biochemistry and Molecular Biology, University of Bari, 70126 Bari, Italy.

Matrix metalloproteinases (MMPs) have been identified as mediators of brain injury in HIV-associated neurological diseases. The activity of the 72 kDa gelatinase A (MMP-2) and 92 kDa gelatinase B (MMP-9) was detected by zymography in the cerebrospinal fluid (CSF) of 138 HIV-infected patients (40 with AIDS dementia, 83 with brain opportunistic infections and 15 neurologically asymptomatic), 26 HIV-seronegative individuals with inflammatory neurological diseases (IND) and 12 HIV-seronegative subjects with noninflammatory neurological diseases (NIND). MMP-2 was present in all CSF samples from HIV-seropositive and HIV-seronegative individuals, including those of subjects with NIND. Read More

View Article and Full-Text PDF
  • Page 1 of 1