Search Our Scientific Publications & Authors

J Alzheimers Dis 2017 ;60(s1):S169-S193

Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.

With increasing survival of patients infected with human immunodeficiency virus type 1 (HIV-1), the manifestation of heterogeneous neurological complications is also increasing alarmingly in these patients. Currently, more than 30% of about 40 million HIV-1 infected people worldwide develop central nervous system (CNS)-associated dysfunction, including dementia, sensory, and motor neuropathy. Furthermore, the highly effective antiretroviral therapy has been shown to increase the prevalence of mild cognitive functions while reducing other HIV-1-associated neurological complications. Read More

Curr HIV Res 2016 ;14(5):389-399

HIV Neuropathogenesis, Genetics, and Therapeutics Branch, Division of AIDS Research, National Institute of Mental Health, Bethesda, MD-20892, USA.

Background: Over the past three decades, the clinical presentation of HIV infection of the Central Nervous System (CNS) has evolved. Prior to wide spread use of effective antiretroviral therapy (ART), more than a third of infected individuals exhibited a range of neurocognitive and motor deficits that frequently progressed to severe dementia and paralysis. However, the use of ART has significantly decreased the prevalence of severe forms of HIV-1 associated neurocognitive disorders (HAND). Read More

Neuropsychol Rev 2009 Jun 9;19(2):169-85. Epub 2009 May 9.

Brain Sciences, University of New South Wales, and Department of Neurology, Xavier Building, Level 4, St. Vincent's Hospital, 390 Victoria Street, Sydney, NSW, 2010, Australia.

This article presents a review of studies that have investigated the neuropsychological effects of antiretroviral treatment (ART) for HIV-1 infection. It provides a brief overview of the era of monotherapy, dual-therapy, and an extended overview of the current era of combination antiretroviral therapy (CART). This review highlights that while CART has had a dramatic effect on the incidence and the severity of HIV-associated neurocognitive disorders (HAND), HAND, in its mild form, still remains prevalent. Read More

Indian J Med Res 2005 Apr;121(4):468-88

Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore 560 029, India.

Neurological manifestations of HIV infection and AIDS are being recognized with a frequency that parallels the increasing number of AIDS cases. Next to sub-Saharan Africa, India has the second largest burden of HIV related pathology, essentially caused by HIV-1 clade C in both the geographic locales, in contrast to USA and Europe. But the true prevalence of HIV related neuroinfections and pathology is not available due to inadequate medical facilities, social stigma and ignorance that lead to underdiagnosis. Read More