1,277 results match your criteria HIV Nephropathy


Nephrotic Syndrome in South African Children: Changing Perspectives in the New Millennium.

Kidney Int Rep 2019 Apr 12;4(4):522-534. Epub 2019 Feb 12.

Department of Paediatrics and Child Health, College of Health Sciences, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

The epidemiological landscape of nephrotic syndrome (NS) in South Africa has changed drastically in the New Millennium. Although the pattern of disease in the 3 main non-Black racial groups (White, Indian, and Mixed race) mirror that seen in Western countries, Black African children show a pattern of disease that is at variance with these 3 racial groups. The incidence of infectious diseases, particularly hepatitis B virus associated nephropathy has sharply declined to being almost extinct in Black children in the New Millennium whereas HIV-related nephropathy surfaced. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24680249193004
Publisher Site
http://dx.doi.org/10.1016/j.ekir.2019.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451079PMC
April 2019
2 Reads

Kidney disease in africans with hiv and tuberculosis.

AIDS 2019 Mar 19. Epub 2019 Mar 19.

King's College London, London, UK.

Objective: To describe the spectrum of kidney disease in African patients with HIV and tuberculosis (TB).

Methods: We used data from three cohorts: consecutive patients with HIV/TB in South London (UK, 2004-2016; n = 95), consecutive patients with HIV/TB who underwent kidney biopsy in Cape Town (South Africa, 2014-2017; n = 70), and consecutive patients found to have HIV/TB on autopsy in Abidjan (Cote d'Ivoire, 1991; n = 100). Acute kidney injury (AKI) was ascertained using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000002204DOI Listing
March 2019
3 Reads

Membranous Nephropathy in a Patient with Human Immunodeficiency Virus Shortly After Initiation of HAART with Atripla.

Cureus 2019 Jan 21;11(1):e3932. Epub 2019 Jan 21.

Internal Medicine, Charleston Area Medical Center, Charleston, USA.

A human immunodeficiency virus (HIV) infection has long been associated with kidney disease. The pathogenesis of renal complications may be directly related to the presence of HIV viral particles or may occur secondary to an immune response against the virus. A number of HIV medications have been associated with the development of acute and chronic kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430309PMC
January 2019
1 Read

Refractory ascites as a presenting feature of extramedullary plasmacytoma in an end-stage renal disease patient with HIV infection.

Clin Nephrol Case Stud 2019 10;7:7-10. Epub 2019 Feb 10.

Department of Medicine, Division of Nephrology, Medical University of South Carolina.

Refractory ascites as the only presenting feature of an extramedullary plasmacytoma complicating end-stage renal disease and HIV infection has not been described yet. We describe a case of a 39-year-old female with HIV-associated nephropathy manifesting with ascites formation after transition from peritoneal dialysis (PD) to hemodialysis (HD). Earlier on, she received cycler-assisted PD for 5 years uneventfully. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5414/CNCS109560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374990PMC
February 2019
3 Reads

Impact of Genetic Variants on HIV-1 Infection and Disease Progression.

Front Immunol 2019 24;10:53. Epub 2019 Jan 24.

Molecular Genetic Epidemiology Section, Basic Science Program, Basic Research Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, United States.

Apolipoprotein L1 (APOL1) has broad innate immune functions and has been shown to restrict HIV replication by multiple mechanisms. Coding variants in are strongly associated with HIV-associated nephropathy (HIVAN) in persons with untreated HIV infection; however, the mechanism by which variant protein potentiates renal injury in the presence of high viral load is not resolved. Little is known about the association of genotypes with HIV viral load, HIV acquisition, or progression to AIDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353846PMC
January 2019
7 Reads

The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa.

BMC Nephrol 2019 Feb 6;20(1):44. Epub 2019 Feb 6.

Division of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Background: The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.

Methods: All included patients had histological evidence of either collapsing or non-collapsing focal segmental glomerulosclerosis (FSGS) or podocyte and/or parietal cell hypertrophy or hyperplasia. All patients had evidence of tubulointerstitial inflammation with microcysts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1208-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366071PMC
February 2019
2 Reads

Low incidence of acute rejection within 6 months of kidney transplantation in HIV-infected recipients treated with raltegravir: the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE trial.

HIV Med 2019 Mar 27;20(3):202-213. Epub 2019 Jan 27.

Nephrology and Kidney Transplantation Department, Assistance Publique-Hôpitaux de Paris, Institut Francilien de Recherche en Néphrologie et Transplantation, Groupe Hospitalier Henri-Mondor/Albert-Chenevier, Créteil, France.

Objectives: High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV-infected recipients treated with a protease-inhibitor-free raltegravir-based regimen.

Methods: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single-arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV-1 RNA copies/mL, CD4 T-cell count > 200 cells/μL, and HIV-1 strains sensitive to raltegravir, aiming to demonstrate 6-month clinical acute rejection rates < 30%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hiv.12700DOI Listing
March 2019
4 Reads

HIVAN associated tubular pathology with reference to ER stress, mitochondrial changes, and autophagy.

Exp Mol Pathol 2019 02 31;106:139-148. Epub 2018 Dec 31.

Department of Neurology, University of Maryland, Baltimore, MD 21201, United States; VA Medical Center, Baltimore, MD 21201, United States. Electronic address:

Human immunodeficiency virus associated nephropathy (HIVAN) is a unique form of a renal parenchymal disorder. This disease and its characteristics can be accredited to incorporation of DNA and mRNA of human immunodeficiency virus type 1 into the renal parenchymal cells. A proper understanding of the intricacies of HIVAN and the underlying mechanisms associated with renal function and disorders is vital for the potential development of a reliable treatment for HIVAN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2018.12.009DOI Listing
February 2019
6 Reads

Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels.

FASEB J 2019 Mar 6;33(3):3718-3730. Epub 2018 Dec 6.

Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201800885RRDOI Listing
March 2019
2 Reads

Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

BMC Nephrol 2018 Nov 20;19(1):331. Epub 2018 Nov 20.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et de Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000, Créteil, France.

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-018-1132-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247501PMC
November 2018
17 Reads

Tyro3 is a podocyte protective factor in glomerular disease.

JCI Insight 2018 11 15;3(22). Epub 2018 Nov 15.

Department of Medicine/Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Our previous work demonstrated a protective role of protein S in early diabetic kidney disease (DKD). Protein S exerts antiinflammatory and antiapoptotic effects through the activation of TYRO3, AXL, and MER (TAM) receptors. Among the 3 TAM receptors, we showed that the biological effects of protein S were mediated largely by TYRO3 in diabetic kidneys. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.123482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302948PMC
November 2018
4 Reads

The Role of Glucocorticoid Receptors in Podocytes and Nephrotic Syndrome.

Nucl Receptor Res 2018 24;5. Epub 2018 Apr 24.

Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

Glucocorticoid receptor (GC), a founding member of the nuclear hormone receptor superfamily, is a glucocorticoid-activated transcription factor that regulates gene expression and controls the development and homeostasis of human podocytes. Synthetic glucocorticoids are the standard treatment regimens for proteinuria (protein in the urine) and nephrotic syndrome (NS) caused by kidney diseases. These include minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN) and immunoglobulin A nephropathy (IgAN) or subsequent complications due to diabetes mellitus or HIV infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11131/2018/101323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224173PMC
April 2018
2 Reads

Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.

Kidney Int 2018 12 23;94(6):1160-1176. Epub 2018 Oct 23.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Kidney Center at James J. Peters VA Medical Center, Bronx, New York, USA. Electronic address:

Mounting evidence suggests that epigenetic modification is important in kidney disease pathogenesis. To determine whether epigenetic regulation is involved in HIV-induced kidney injury, we performed genome-wide methylation profiling and transcriptomic profiling of human primary podocytes infected with HIV-1. Comparison of DNA methylation and RNA sequencing profiles identified several genes that were hypomethylated with corresponding upregulated RNA expression in HIV-infected podocytes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00852538183058
Publisher Site
http://dx.doi.org/10.1016/j.kint.2018.07.023DOI Listing
December 2018
19 Reads

APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD.

Am J Kidney Dis 2018 Nov;72(5S1):S8-S16

Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. Electronic address:

Genetic methodologies are improving our understanding of the pathophysiology in diverse diseases. Breakthroughs have been particularly impressive in nephrology, for which marked disparities exist in rates and etiologic classifications of end-stage kidney disease between African Americans and European Americans. Discovery of the apolipoprotein L1 gene (APOL1) association with focal segmental glomerulosclerosis, human immunodeficiency virus (HIV)-associated nephropathy, lupus nephritis, sickle cell nephropathy, and solidified glomerulosclerosis, as well as more rapid failure of transplanted kidneys from donors with APOL1 renal-risk genotypes, has improved our understanding of nondiabetic nephropathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02726386183082
Publisher Site
http://dx.doi.org/10.1053/j.ajkd.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200346PMC
November 2018
28 Reads

Protective association between JC polyoma viruria and kidney disease.

Curr Opin Nephrol Hypertens 2019 Jan;28(1):65-69

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Purpose Of Review: The presence of viruses in urine (urine virome) typically reflects infection in the kidneys and urinary tract. The urinary virome is associated with HIV-associated nephropathy and chronic glomerulosclerosis. There are many associations of this microbiome with human diseases that remain to be described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNH.0000000000000464DOI Listing
January 2019
21 Reads

Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):610-613

Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India.

Highly active anti retroviral therapy (HAART) has dramatically improved life expectancy of human immunodeficiency virus (HIV) infected patients, converting HIV infection into a chronic illness with associated changes in its attendant renal complications. The past two decades have witnessed a decrease in the prevalence of HIV associated nephropathy (HIVAN), traditionally considered to be the hall mark of renal involvement in HIV infection. Simultaneously a host of other glomerular and tubulo-interstitial diseases have emerged, expanding the spectrum of HIV associated renal diseases, predominant among which is HIV associated immune complex mediated kidney diseases (HIVICK). Read More

View Article

Download full-text PDF

Source
http://www.ijpmonline.org/text.asp?2018/61/4/610/242993
Publisher Site
http://dx.doi.org/10.4103/IJPM.IJPM_52_18DOI Listing
February 2019
12 Reads
0.642 Impact Factor

Autoimmune Kidney Diseases Associated with Chronic Viral Infections.

Rheum Dis Clin North Am 2018 11 7;44(4):675-698. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, GRB 7, Boston, MA 02114, USA. Electronic address:

Autoimmune kidney diseases triggered by viruses are an important cause of kidney disease in patients affected by chronic viral infection. Hepatitis B virus (HBV) infection is associated with membranous nephropathy and polyarteritis nodosa. Hepatitis C virus (HCV) infection is a major cause of cryoglobulinemic glomerulonephritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rdc.2018.06.006DOI Listing
November 2018
4 Reads

Association of HIV Suppression With Kidney Disease Progression Among HIV-Positive African Americans With Biopsy-Proven Classic FSGS.

J Acquir Immune Defic Syndr 2018 Dec;79(5):639-643

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: In the era of combined antiretroviral therapy, classic focal segmental glomerulosclerosis (FSGS) is the most common histopathological finding in African American HIV-positive patients with kidney disease. We sought to determine whether HIV suppression is associated with lower risk of progression to end-stage renal disease (ESRD) among HIV-positive African Americans with biopsy-confirmed classic FSGS.

Methods: HIV-positive African Americans who underwent kidney biopsies at a single tertiary hospital between January 1996 and June 2011 were confirmed as having classic FSGS by the presence of segmental glomerulosclerosis without features of HIV-associated nephropathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231978PMC
December 2018
13 Reads

Podocyte-Specific Induction of Krüppel-Like Factor 15 Restores Differentiation Markers and Attenuates Kidney Injury in Proteinuric Kidney Disease.

J Am Soc Nephrol 2018 Oct 24;29(10):2529-2545. Epub 2018 Aug 24.

Divisions of Nephrology and

Background: Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, and destabilization of the podocyte's actin cytoskeleton contributes to podocyte dysfunction in many of these conditions. Although agents, such as glucocorticoids and cyclosporin, stabilize the actin cytoskeleton, systemic toxicity hinders chronic use. We previously showed that loss of the kidney-enriched zinc finger transcription factor Krüppel-like factor 15 (KLF15) increases susceptibility to proteinuric kidney disease and attenuates the salutary effects of retinoic acid and glucocorticoids in the podocyte. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2018030324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171275PMC
October 2018
6 Reads
9.343 Impact Factor

Case of human immunodeficiency virus infection presenting as a tip variant of focal segmental glomerulosclerosis: A case report and review of the literature.

World J Nephrol 2018 Aug;7(4):90-95

Division of Nephrology, Hamamatsu Medical Center, Hamamatsu 432-8580, Japan.

The incidence of the collapsing variant of focal segmental glomerulosclerosis (FSGS) as a human immunodeficiency virus (HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy (ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5527/wjn.v7.i4.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081390PMC
August 2018
4 Reads

APOL1 risk variants and kidney disease: what we know so far.

J Bras Nefrol 2018 Oct-Dec;40(4):388-402. Epub 2018 Jul 26.

Beth Israel Deaconess Medical Center, Boston, MA, United States.

There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carries by protecting against forms of trypanosomiasis, but at the expense of an increased risk of kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-2017-0033DOI Listing
July 2018
15 Reads

Prevalence, Risk Factors, and Pathophysiology of Dysglycemia among People Living with HIV in Sub-Saharan Africa.

J Diabetes Res 2018 23;2018:6916497. Epub 2018 May 23.

Division of Infectious Diseases, Vanderbilt University Medical Center, A2200-MCN 1161 21st Avenue South, Nashville, TN 37232, USA.

Objective: To review available literature on the prevalence, risk factors, pathophysiology, and clinical outcomes of dysglycemia among people living with HIV (PLHIV) in sub-Saharan Africa (SSA).

Methods: Database search on PUBMED for eligible studies describing the prevalence, risk factors, pathophysiology, or clinical outcomes of dysglycemia in SSA PLHIV.

Results: Prevalence of diabetes mellitus (DM) and pre-DM among SSA PLHIV ranged from 1% to 26% and 19% to 47%, respectively, in 15 identified studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6916497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989168PMC
December 2018
15 Reads

Survival of HIV infected patients on maintenance hemodialysis in Cameroon: a comparative study.

BMC Nephrol 2018 07 5;19(1):166. Epub 2018 Jul 5.

Faculty of Medicine and Biomedical Sciences, Department of internal medicine- Douala general hospital Cameroon, Douala, University of Yaoundé I, Cameroon.

Background: There are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of their HIV negative counterparts with ESKD on maintenance haemodialysis in Cameroon.

Methods: This was a retrospective cohort study conducted in the haemodialysis units of the Douala and Yaoundé General Hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-018-0964-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034298PMC
July 2018
24 Reads

Molecular Mechanisms of Injury in HIV-Associated Nephropathy.

Front Med (Lausanne) 2018 7;5:177. Epub 2018 Jun 7.

Division of Nephrology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, United States.

HIV-associated nephropathy (HIVAN) is an important cause of secondary focal glomerulosclerosis that occurs primarily in persons of African ancestry with advanced HIV disease. Although HIVAN is characterized by severe proteinuria and rapid progression to end stage renal disease without treatment, the phenotype is markedly attenuated by treatment with antiretroviral medications. HIV infection of glomerular and tubular epithelial cells and subsequent viral gene expression is a key contributor to HIVAN pathogenesis and the kidney can serve as reservoir for HIV strains that differ those in blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2018.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999756PMC
June 2018
3 Reads

HIV and Aging - Perhaps Not as Dramatic as We Feared?

Gerontology 2018 15;64(5):446-456. Epub 2018 Jun 15.

University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz, Switzerland.

Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489172DOI Listing
December 2018
20 Reads

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.

Kidney Int 2018 09 7;94(3):599-607. Epub 2018 Jun 7.

Center for Public Health Genomics; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Center for Diabetes Research; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address:

African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exogenous (interferon treatment) environmental modifiers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109415PMC
September 2018
52 Reads

HIV-associated nephropathy: links, risks and management.

HIV AIDS (Auckl) 2018 25;10:73-81. Epub 2018 May 25.

Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Despite the decreased incidence of human immunodeficiency virus (HIV)-associated nephropathy due to the widespread use of combined active antiretroviral therapy, it remains one of the leading causes of end-stage renal disease (ESRD) in HIV-1 seropositive patients. Patients usually present with low CD4 count, high viral load and heavy proteinuria, with the pathologic findings of collapsing focal segmental glomerulosclerosis. Increased susceptibility exists in individuals with African descent, largely due to polymorphism in gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/HIV.S141978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975615PMC
May 2018
32 Reads

AQP4 and HIVAN.

Exp Mol Pathol 2018 08 18;105(1):71-75. Epub 2018 May 18.

Department of Neurology, University of Maryland, Baltimore, MD, United States; VA Medical Center, Baltimore, MD, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2018.05.004DOI Listing
August 2018
6 Reads

Spectrum of renal disease in HIV-infected children: report of five cases.

Paediatr Int Child Health 2018 11 4;38(4):271-276. Epub 2018 May 4.

a Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre , PGIMER , Chandigarh , India.

There is a paucity of literature on renal diseases associated with HIV infection in Asian countries. Renal disease in HIV-infected children can involve the glomerulus, interstitium, tubules or blood vessels of the kidney. In this case series, five HIV-infected children with various forms of renal disease are reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20469047.2018.1463126DOI Listing
November 2018
31 Reads

Protective Effects of Ginsenoside Rb1 against Blood-Brain Barrier Damage Induced by Human Immunodeficiency Virus-1 Tat Protein and Methamphetamine in Sprague-Dawley Rats.

Am J Chin Med 2018 ;46(3):551-566

† School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, P. R. China.

Although antiretroviral therapy has helped to improve the lives of individuals infected with human immunodeficiency virus 1 (HIV-1), these patients are often still afflicted with HIV-1-associated neurocognitive disorders, which can lead to neurocognitive impairment and even dementia, and continue to hamper their quality of life. Methamphetamine abuse in HIV-1 patients poses a potential risk for HIV-associated neurocognitive disorders, because methamphetamine and HIV-1 proteins such as transactivator of transcription can synergistically damage the blood-brain barrier (BBB). In this study, we aimed to examine the effects of methamphetamine and HIV-1 Tat protein on the blood-brain barrier function and to determine whether ginsenoside Rb1 (GsRb1) plays a role in protecting the BBB. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X18500283DOI Listing
July 2018
28 Reads

Renal effects of non-tenofovir antiretroviral therapy in patients living with HIV.

Drugs Context 2018 21;7:212519. Epub 2018 Mar 21.

Chicago College of Pharmacy, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA.

A review of literature published regarding non-tenofovir antiretroviral agents causing renal adverse effects was conducted. The literature involving renal adverse effects and antiretroviral therapy is most robust with protease inhibitors, specifically atazanavir and indinavir, and includes reports of crystalluria, leukocyturia, nephritis, nephrolithiasis, nephropathy and urolithiasis. Several case reports describe potential nephropathy (including Fanconi syndrome) secondary to administration of abacavir, didanosine, lamivudine and stavudine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7573/dic.212519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866095PMC
March 2018
8 Reads

Glomerular mitochondrial changes in HIV associated renal injury.

Exp Mol Pathol 2018 06 31;104(3):175-189. Epub 2018 Mar 31.

Department of Neurology, University of Maryland, Baltimore, MD, United States. Electronic address:

HIV-associated nephropathy (HIVAN) is an AIDs-related disease of the kidney. HIVAN is characterized by severe proteinuria, podocyte hyperplasia, collapse, glomerular, and tubulointerstitial damage. HIV-1 transgenic (Tg26) mouse is the most popular model to study the HIV manifestations that develop similar renal presentations as HIVAN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2018.03.004DOI Listing
June 2018
11 Reads

Renal aquaporin-4 associated pathology in TG-26 mice.

Exp Mol Pathol 2018 06 31;104(3):239-249. Epub 2018 Mar 31.

Department of Neurology, University of Maryland, Baltimore, MD, United States; VA Medical Center, Baltimore, MD, United States. Electronic address:

Human immunodeficiency virus-associated nephropathy (HIVAN) is a leading cause of end-stage renal disease in HIV patients, which is characterized by glomerulosclerosis and renal tubular dysfunction. Aquaporin-4 (AQP-4) is a membrane bound water channel protein that plays a distinct role in water reabsorption from renal tubular fluid. It has been proven that failure of AQP-4 insertion into the renal tubular membrane leads to renal dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2018.03.005DOI Listing
June 2018
12 Reads

Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: Case report and review of the literature
.

Clin Nephrol 2018 May;89(5):381-386

The most common renal disease associated with human immunodeficiency virus infection (HIV) is HIV-associated nephropathy (HIVAN), especially in the African American patient population. However, various patterns of glomerulonephritis (GN) are not uncommon, collectively accounting for nearly half of the renal biopsies performed in HIV patients. Most GNs that occur in HIV patients are immune complex mediated, often with concurrent infections such as hepatitis B or C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5414/CN109215DOI Listing
May 2018
13 Reads

The prevalence and isolated subtypes of BK polyomavirus reactivation among patients infected with human immunodeficiency virus-1 in southeastern China.

Arch Virol 2018 Jun 12;163(6):1463-1468. Epub 2018 Feb 12.

The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

BK polyomavirus (BKPyV) is an opportunistic infectious pathogen that is associated with hemorrhagic cystitis and nephropathy, mainly in transplant recipients and human immunodeficiency virus 1 (HIV-1) infected patients. However, molecular characterization studies of BKPyV in China are rare. This study was designed to elucidate the prevalence and to determine the main subtypes of BKPyV among HIV-1-infected patients in southeastern China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00705-018-3724-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958166PMC
June 2018
14 Reads

Brief Report: Abacavir/Lamivudine and Tenofovir/Emtricitabine in Pregnant Women With HIV: Laboratory and Clinical Outcomes in an Observational National Study.

J Acquir Immune Defic Syndr 2018 May;78(1):99-104

Department of Infectious Diseases, Catholic University, Rome, Italy.

Background: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational study.

Methods: Laboratory measures (CD4, HIV-RNA, lipid profile, glucose, hemoglobin, and alanine transferase) and pregnancy outcomes (preterm delivery, low birthweight, nonelective cesarean section, birthweight Z-score, congenital defects, HIV transmission, maternal weight gain, and pregnancy complications) were compared after prenatal exposure to ABC/3TC or TDF/FTC. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00126334-201805010-0001
Publisher Site
http://dx.doi.org/10.1097/QAI.0000000000001640DOI Listing
May 2018
29 Reads

Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2018 03 3;93(3):545-559. Epub 2018 Feb 3.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney disease, and comorbid kidney disease, as well as kidney injury resulting from prolonged exposure to antiretroviral therapy or from opportunistic infections. Clinical guidelines for kidney disease prevention and treatment in HIV-positive individuals are largely extrapolated from studies in the general population, and do not fully incorporate existing knowledge of the unique HIV-related pathways and genetic factors that contribute to the risk of kidney disease in this population. We convened an international panel of experts in nephrology, renal pathology, and infectious diseases to define the pathology of kidney disease in the setting of HIV infection; describe the role of genetics in the natural history, diagnosis, and treatment of kidney disease in HIV-positive individuals; characterize the renal risk-benefit of antiretroviral therapy for HIV treatment and prevention; and define best practices for the prevention and management of kidney disease in HIV-positive individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983378PMC
March 2018
31 Reads

Sonographic evaluation of kidney echogenicity and morphology among HIV sero-positive adults at Lagos University Teaching Hospital.

J Ultrasound 2018 Mar 5;21(1):25-34. Epub 2018 Jan 5.

Department of Radiation Biology, Radiotherapy, Radiodiagnosis and Radiography, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Ishaga Road, Idi-araba, Lagos, Nigeria.

Aim: To evaluate the role of kidney echogenicity and morphology in the diagnosis of human immunodeficiency virus-associated nephropathy (HIVAN).

Subjects And Methods: In the cross-sectional study, a sample of 340 anti-retroviral therapy (ART)-naïve AIDS patients underwent laboratory CD4+ count, serum creatinine determination and sonographic renal echogenicity grading and size measurement. Rounded kidneys were described as bulbous while bean-shaped kidneys were described as reniform; echogenicity was categorized into grades 0, 1, 2 and 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40477-017-0279-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845938PMC
March 2018
4 Reads

HIV and renal disease: a contemporary review.

Int J STD AIDS 2018 06 17;29(7):714-719. Epub 2018 Jan 17.

Division of Nephrology and Renal Transplantation, Department of Medicine Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

The presence of human immunodeficiency virus (HIV)-related kidney disease is an important cause of mortality and morbidity. HIV infection induces renal injury by direct cytotoxicity or immune complex-mediated glomerulonephritis in patients with genetic susceptibility factors. In the last decades, with the development and diffusion of combination antiretroviral therapy, which has prolonged patient survival, there has been a shift in the spectrum of renal diseases in HIV-infected patients, with the decrease of glomerular diseases and increase in the role of nephrotoxicity and co-morbidities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0956462417750710DOI Listing
June 2018
6 Reads

Changing concepts of HIV infection and renal disease.

Curr Opin Nephrol Hypertens 2018 05;27(3):144-152

Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Purpose Of Review: Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) was identified as the major renal manifestation of HIV infection early in the HIV epidemic. However, HIV infection now is associated with a different spectrum of renal lesions leading to chronic kidney disease. This review examines the changes in kidney injury occurring in the current HIV era and the factors involved in this transformation of disease expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNH.0000000000000400DOI Listing
May 2018
7 Reads

HIV-Positive Kidney Donor Selection for HIV-Positive Transplant Recipients.

J Am Soc Nephrol 2018 Apr 12;29(4):1090-1095. Epub 2018 Jan 12.

Division of Nephrology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town, South Africa.

The risks associated with transplanting HIV-positive kidneys into HIV-positive recipients have not been well studied. Since 2008, 43 kidneys from 25 HIV-positive deceased donors have been transplanted into patients who are HIV positive in Cape Town, South Africa. Among the donors, 19 (76%) died secondary to trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2017080853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875954PMC
April 2018
6 Reads

Proliferative lupus nephritis in the absence of overt systemic lupus erythematosus: A historical study of 12 adult patients.

Medicine (Baltimore) 2017 Dec;96(48):e9017

Service de néphrologie, CHU Bichat, AP-HP, INSERM U1199, Paris Diderot University and DHU FIRE, Paris, France.

Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome.We conducted a historical observational study of 12 adult (age >18 years) patients with biopsy-proven severe lupus nephritis or lupus-like nephritis without SLE immunological markers at diagnosis or during follow-up. Excluded were patients with chronic infections with HIV or hepatitis B or C; patients with a bacterial infectious disease; and patients with pure membranous nephropathy. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201712010-0009
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000009017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728820PMC
December 2017
54 Reads

Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature.

Case Reports Hepatol 2017 15;2017:3921027. Epub 2017 Nov 15.

Infectious Diseases Unit, Department of Medical and Surgical Science, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Tenofovir disoproxil fumarate- (TDF-) related nephropathy is known to be a long-term complication of this drug, more commonly observed in HIV-infected patients, but occurring also in hepatitis B. Cases of Fanconi Syndrome associated with TDF have been reported in adult patients, usually as a long-term complication of chronic hepatitis B treatment. We present here a case of a 12-year-old male developing a severe acute HBV hepatitis treated with TDF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/3921027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705871PMC
November 2017
44 Reads

Podocan Is Expressed in Blood and Adipose Tissue and Correlates Negatively With the Induction of Diabetic Nephropathy.

J Endocr Soc 2017 Jul 16;1(7):772-786. Epub 2017 May 16.

Japan Medical Affairs, Japan Pharma Business Unit, Takeda Pharmaceutical Company Limited, Chuo-ku, Tokyo 103-8686, Japan.

Podocan, a member of the small leucine-rich repeat proteoglycans (SLRPs), is expressed in vascular endothelial cells with high levels of expression in the sclerotic glomerular lesions of experimental HIV-associated nephropathy. It is also found in vascular smooth muscle cells and is involved in atherosclerosis. Decorin, a protein similar to podocan, also belongs to the SLRP family and is highly expressed in adipose tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/js.2017-00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686772PMC
July 2017
4 Reads

HIV-Associated Nephropathy in Africa: Pathology, Clinical Presentation and Strategy for Prevention.

J Clin Med Res 2018 Jan 1;10(1):1-8. Epub 2017 Dec 1.

Department of HIV and Blood Borne Viruses, Milton Keynes University Hospital, NHS Foundation Trust, Milton Keynes, UK.

The human immunodeficiency virus (HIV) infection can lead to progressive decline in renal function known as HIV-associated nephropathy (HIVAN). Importantly, individuals of African ancestry are more at risk of developing HIVAN than their European descent counterparts. An in-depth search on Google Scholar, Medline and PubMed was conducted using the terms "HIVAN" and "pathology and clinical presentation", in addition to "prevalence and risk factors for HIVAN", with special emphasis on African countries for any articles published between 1990 and 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14740/jocmr3235wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722038PMC
January 2018
15 Reads

Secondary Syphilis Associated with Membranous Nephropathy and Acute Hepatitis in a Patient with HIV: A Case Report.

Perm J 2018 ;22:17-062

Nephrology Fellowship Program Director at the Los Angeles Medical Center in CA.

Introduction: We present a case of membranous nephropathy associated with a secondary syphilis infection in a patient with HIV.

Case Presentation: A 37-year-old white man with HIV who was receiving highly active antiretroviral therapy presented to the Emergency Department with 6 weeks of rectal pain. He had a CD3-CD4 count of 656 cells/mm and an undetectable viral load. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7812/TPP/17-062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737919PMC
July 2018
10 Reads

Kidney Diseases Associated with Human Immunodeficiency Virus Infection.

N Engl J Med 2017 12;377(24):2363-2374

From the Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC (S.D.C., P.L.K.); and the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (J.B.K., P.L.K.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMra1508467DOI Listing
December 2017
10 Reads

Pharmacotherapy and treatment options for HIV-associated nephropathy.

Expert Opin Pharmacother 2018 01 26;19(1):39-48. Epub 2017 Dec 26.

a Johns Hopkins Department of Medicine , Division of Nephrology , Baltimore , MD , US.

Introduction: Human immunodeficiency virus (HIV) remains a worldwide disease with significant mortality and morbidity. There are a multitude of HIV-related kidney diseases including HIV-associated nephropathy (HIVAN) most prominently. The risk of developing HIVAN increases with decreasing CD4 count, higher viral load, and based on genetic factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2017.1416099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381591PMC
January 2018
17 Reads

A case of hepatic Kaposi's sarcoma diagnosed by transgastric biopsy.

Gastrointest Endosc 2018 07 6;88(1):188-189. Epub 2017 Dec 6.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2017.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988905PMC
July 2018
7 Reads

Nephrotic syndrome due to lupus-like glomerulonephritis in an HIV-positive patient.

Neth J Med 2017 Nov;75(9):412-414

Department of Nephrology, University Medical Centre Groningen, Groningen, the Netherlands.

Lupus nephritis, a well-known complication in systemic lupus erythematosus, is characterised by a proliferative glomerulonephritis or membranous nephropathy along with a full-house immunofluorescence pattern on renal biopsy. There are very few exceptions in which similar histopathological findings are present, but case reports show that an increasing number of HIV-positive patients (mostly black Africans, but also white patients) have HIV-immune complex disease (HIVICK), which can mimic lupus nephritis. Lupus-like HIVICK is treated differently than 'true' lupus nephritis, so distinction is warranted. Read More

View Article

Download full-text PDF

Source
November 2017
15 Reads