310,717 results match your criteria HIV Infection


Report: A case report on Nevirapine induced exfoliative dermatitis.

Pak J Pharm Sci 2019 Jan;32(1):221-222

Department of General Medicine, Rajiv Gandhi institute of medical sciences, Kadapa, India.

Drug induced adverse drug reactions is more common in long term therapy particularly in immune compromised patients. Most of the drugs causing dermatological reactions like skin rashes, pruritus, steven johnson syndrome and exfoliative dermatitis. Nevirapine is the first line drug for human immunodeficiency virus (HIV) infection from the category of non-nucleoside reverse transcriptase enzyme inhibitor (NNRTI). Read More

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January 2019

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil.

Braz J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil; Universidade Federal da Bahia, Bahia, Departamento de Medicina, Salvador, BA, Brazil. Electronic address:

Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.

Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14138670183055
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http://dx.doi.org/10.1016/j.bjid.2018.12.002DOI Listing
February 2019
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Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil.

Epidemics 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, United Kingdom.

Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Read More

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http://dx.doi.org/10.1016/j.epidem.2019.02.002DOI Listing
February 2019

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands.

Bioorg Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8150, Japan. Electronic address:

The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis. With the aim of enhancing the binding affinity and anti-HIV activity of a potent CXCR4 ligand as a lead, 23 low molecular weight compounds containing dipicolylamine (Dpa) and cyclam cationic moieties with varying spacers and spatial positioning were designed, synthesized and biologically evaluated. All of the synthesized compounds screened at 1. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.02.013DOI Listing
February 2019

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
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http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
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Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.

Drug Discov Today 2019 Feb 13. Epub 2019 Feb 13.

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address:

Natural killer (NK) cells are innate immune lymphocytes with a key role in host defense against HIV infection. Recent advances in chimeric antigen receptors (CARs) have made NK cells a prime target for expressing recombinant receptors capable of redirecting NK cytotoxic functions towards HIV-infected cells. In this review, we discuss the role of NK cells in HIV and the mechanisms of actions of HIV-targeting CAR strategies. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.02.002DOI Listing
February 2019

HTLV prevalence is no longer following the decreasing HIV prevalence - 20 years of retroviral surveillance in Guinea-Bissau, West Africa.

Acta Trop 2019 Feb 13. Epub 2019 Feb 13.

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; Department of Clinical Immunology, Aarhus University Hospital, Denmark.

Background: The HIV-2 and HTLV-1 prevalences in Bissau have followed similar trends in surveys from 1996 and 2006 with HTLV-1 prevalences of 3.6% and 2.3%, respectively. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.015DOI Listing
February 2019

Effects of a Short Message Service (SMS) Intervention on Reduction of HIV Risk Behaviours and Improving HIV Testing Rates Among Populations located near Roadside Wellness Clinics: A Cluster Randomised Controlled Trial in South Africa, Zimbabwe and Mozambique.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

Department of Economics, University of Gothenburg, Gothenburg, Sweden.

Short Message Service (SMS) offers an innovative method of promoting sexual health to key and vulnerable populations who are users of mobile phones and are at high risk of HIV infection. This cluster randomised control trial tests the effectiveness of a SMS intervention in reducing HIV risk behaviours and improving HIV testing behaviours among truck drivers, sex workers and community residents located near Roadside Wellness Clinics (RWCs) in three southern African countries. The SMS arm received 35 HIV risk reduction and HIV testing SMSs over a 6-month period. Read More

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http://dx.doi.org/10.1007/s10461-019-02427-6DOI Listing
February 2019

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer.

Cancer Immunol Immunother 2019 Feb 15. Epub 2019 Feb 15.

CureVac AG, Tübingen, Germany.

CV9201 is an RNActive-based cancer immunotherapy encoding five non-small cell lung cancer-antigens: New York esophageal squamous cell carcinoma-1, melanoma antigen family C1/C2, survivin, and trophoblast glycoprotein. In a phase I/IIa dose-escalation trial, 46 patients with locally advanced (n = 7) or metastatic (n = 39) NSCLC and at least stable disease after first-line treatment received five intradermal CV9201 injections (400-1600 µg of mRNA). The primary objective of the trial was to assess safety. Read More

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http://dx.doi.org/10.1007/s00262-019-02315-xDOI Listing
February 2019

Replication competence of virions induced from CD4+ lymphocytes latently infected with HIV.

Retrovirology 2019 Feb 15;16(1). Epub 2019 Feb 15.

San Diego Veterans Affairs Healthcare System, San Diego, CA, USA.

Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir has been quantified with the terminal dilution quantitative viral outgrowth assay, which induces virus propagation in CD4 T cell culture supernatants following cellular activation. Efforts to improve the sensitivity of this inefficient assay have introduced more sensitive p24 ELISA and RNA PCR based endpoints, but these more sensitive endpoints have raised the question whether they are measuring induced replication competent or defective virions. Read More

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http://dx.doi.org/10.1186/s12977-019-0466-1DOI Listing
February 2019

Molecular epidemiology of acute HCV infection in HIV-positive patients from Hong Kong, Taipei, Tokyo.

Liver Int 2019 Feb 16. Epub 2019 Feb 16.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region.

Methods: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei, and Tokyo during 2010-2016 were included in this molecular epidemiology study. Read More

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http://doi.wiley.com/10.1111/liv.14073
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http://dx.doi.org/10.1111/liv.14073DOI Listing
February 2019
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High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

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http://dx.doi.org/10.1093/cid/ciz144DOI Listing
February 2019

Neuropsychiatric symptoms in Tanzanian HIV-infected children receiving long-term efavirenz treatment: a multicentre, cross-sectional, observational study.

Lancet HIV 2019 Feb 12. Epub 2019 Feb 12.

Department of Paediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Background: Efavirenz is commonly prescribed for children with HIV infection, yet little is known about risks of neuropsychiatric side-effects. We aimed to compare competence (social involvement, activities, and school performance) and psychopathology (internalising and externalising problems), cognitive performance (intelligence and working memory), and adherence in Tanzanian children on an efavirenz-based versus a non-efavirenz-based regimen.

Methods: In this multicentre, cross-sectional, observational study, we included consecutive children (aged 6-12 years) with HIV infection, on combination antiretroviral therapy (cART) for at least 6 months, and with viral loads of less than 1000 copies per mL from HIV care clinics of three primary health facilities and three referral hospitals in Moshi, Kilimanjaro, Tanzania. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30329-1DOI Listing
February 2019

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors.

EBioMedicine 2019 Feb 12. Epub 2019 Feb 12.

HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.02.006DOI Listing
February 2019

Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy.

Ann Pharmacother 2019 Feb 15:1060028019833038. Epub 2019 Feb 15.

4 Massachusetts College of Pharmacy and Health Sciences University, School of Pharmacy, Worcester, MA, USA.

Objective: To describe data with selected malignancies in people living with HIV (PLWH) and HIV in individuals affected by both conditions and to summarize drug-drug interactions (DDIs) with clinical recommendations for point-of-care review of combination therapies.

Data Sources: Literature searches were performed (2005 to December 2018) in MEDLINE and EMBASE to identify studies of malignancies in PLWH in the modern era.

Study Selection And Data Extraction: Article bibliographies and drug interaction databases were reviewed. Read More

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http://dx.doi.org/10.1177/1060028019833038DOI Listing
February 2019

Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector.

Viruses 2019 Feb 15;11(2). Epub 2019 Feb 15.

Division of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

A chimeric vesicular stomatitis virus with the glycoprotein of the lymphocytic choriomeningitis virus, VSV-GP, is a potent viral vaccine vector that overcomes several of the limitations of wild-type VSV. Here, we evaluated the potential of VSV-GP as an HIV vaccine vector. We introduced genes for different variants of the HIV-1 envelope protein Env, i. Read More

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http://dx.doi.org/10.3390/v11020159DOI Listing
February 2019

Assessment of voluntary HIV screening for asylum seekers in two Swiss cantons.

Swiss Med Wkly 2019 Feb 15;149:w20020. Epub 2019 Feb 15.

Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland / Departments of Infectious Diseases and of Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Objective: To evaluate the feasibility of HIV screening, offered to newly arrived asylum seekers in the Swiss cantons of Valais (VS) and Vaud (VD) in order to meet the national and international standards for early detection and effective treatment of HIV infections.

Methods: HIV screening was offered free of charge to every asylum seeker who arrived from June 2015 to November 2016 in VS, and from June to October 2016 in VD. Pregnant women and children <16 were excluded. Read More

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http://dx.doi.org/10.4414/smw.2019.20020DOI Listing
February 2019

Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

AP-HP, Hôpital Jean Verdier, Service d'Hépatologie, Bondy, Université Paris 13, Bobigny et INSERM U1162, Université Paris 5, Paris.

Background & Aims: Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelines, evaluating outcomes of patients in the ANRS-CO12 CirVir cohort with compensated cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, with or without a sustained response to antiviral therapy. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.11.053DOI Listing
February 2019

Associations between impulsivity, risk behavior and HIV, HBV, HCV and syphilis seroprevalence among female prisoners in Indonesia: A cross-sectional study.

PLoS One 2019 15;14(2):e0207970. Epub 2019 Feb 15.

Department of Psychiatry, Division of Research, Radboud University Medical Center, Nijmegen, The Netherlands.

HIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior; however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to risk behavior, among female inmates living in a prison in Jakarta (N = 214). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207970PLOS
February 2019

Onward transmission of multiple HIV-1 unique recombinant forms among men who have sex with men in Beijing, China.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Background: Unique recombinant forms (URFs) were generated in dually-infected or multiply-infected individuals, and some of URFs can be transmitted to many people resulting in the emergence of circulating recombinant forms (CRFs). We examined whether there was evidence for onward transmission of multiple URFs among men who have sex with men (MSM) in Beijing.

Methods: A total of 146 MSM subjects with acute/early HIV-1 infection were recruited from the Beijing PRIMO clinical cohort between September 2010 and July 2012. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001983DOI Listing
February 2019

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019

Title: How can programmes better support female sex workers to avoid HIV infection in Zimbabwe? A prevention cascade analysis.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Social and Environmental Health Research, Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Background: 'HIV prevention cascades' have been proposed to support programmes by identifying gaps in demand for, access to and capability to adhere to HIV prevention tools, but there are few empirical examples to guide development. We apply a prevention cascade framework to examine prevention coverage and factors associated with condoms and/or PrEP adherence among female sex workers (FSW).

Setting: Seven sites across Zimbabwe. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001980DOI Listing
February 2019

Plant-derived medicines for neuropathies: a comprehensive review of clinical evidence.

Rev Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.

Neuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies. Read More

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http://dx.doi.org/10.1515/revneuro-2018-0097DOI Listing
February 2019

HIV and Cardiovascular Diseases Risk: Exploring the Interplay between T cell Activation, Coagulation, Monocyte Subsets and Lipid Subclass Alterations.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, South Africa.

Although rollout of combined anti-retroviral treatment (cART) has blunted human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) onset, there is increased development of cardiovascular diseases (CVD) in HIV-infected individuals. While most HIV-infected individuals on cART achieve viral suppression, this may not necessarily result in complete immunological recovery. This study therefore evaluated T cell-mediated changes and coagulation markers in HIV-positive individuals to ascertain their potential to increase CVD risk. Read More

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http://dx.doi.org/10.1152/ajpheart.00797.2018DOI Listing
February 2019

A cascade toehold-mediated strand displacement strategy for label-free and sensitive non-enzymatic recycling amplification detection of the HIV-1 gene.

Analyst 2019 Feb 15. Epub 2019 Feb 15.

Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-Environmental and Science &Technology, Guangzhou 510650, China.

In this work, a label-free fluorescence biosensor for simple detection of the HIV-1 gene was proposed by using toehold-mediated strand displacement reactions (TMSDRs) combined with a non-enzymatic target recycling amplification strategy. In this system, two TMSDRs were used. In the presence of the HIV-1 gene, an autocatalytic DNA machine can be activated. Read More

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http://dx.doi.org/10.1039/c8an02340aDOI Listing
February 2019

[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019

Correlates of Sexually Transmitted Infections Among South African Women Using Individual- and Community-Level Factors: Results from Generalized Additive Mixed Models.

Arch Sex Behav 2019 Feb 14. Epub 2019 Feb 14.

Biostatistics Unit, South African Medical Research Council, Durban, Kwazulu-Natal, South Africa.

South Africa has the highest burden of human immunodeficiency virus (HIV) infections in the world. There is also growing evidence that an individual's risk of contracting HIV is increased by the presence of other sexually transmitted infections (STIs). The primary objective of this study was to examine the association between the prevalence of STIs in a cohort of South African women who enrolled in HIV prevention trials (2002-2012). Read More

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http://dx.doi.org/10.1007/s10508-018-1315-3DOI Listing
February 2019

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

J Neurovirol 2019 Feb 14. Epub 2019 Feb 14.

Department of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1. Read More

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http://dx.doi.org/10.1007/s13365-019-00723-4DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019
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E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals.

Afr Health Sci 2018 Dec;18(4):1066-1075

Division of Chemical Pathology, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.

Background: E-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.

Objectives: This study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354867PMC
December 2018

Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria.

Afr Health Sci 2018 Dec;18(4):1057-1065

Virology Unit, Department of Microbiology, University of Ilorin, P.M.B 1515 Ilorin-Nigeria.

Background: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals.

Objectives: This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354892PMC
December 2018

Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication.

Front Microbiol 2019 31;10:114. Epub 2019 Jan 31.

Virology Lab II, National Institute of Immunology, New Delhi, India.

Human Immunodeficiency Virus-1 (HIV-1) is known to induce the expression of SOCS3 which is a negative feed-back regulator of inflammatory responses. Here, we demonstrate that reactivation of latent HIV-1 leads to degradation of SOCS3 at early time points. Interestingly, SOCS3 degradation following transfection of HIV-1 RNA as well as polyIC in THP-1 cells further confirmed the role of viral RNA signaling in SOCS3 biology. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365456PMC
January 2019

Hepatitis A Virus Prevention and Vaccination Within and Outside the Veterans Health Administration in Light of Recent Outbreaks.

Fed Pract 2018 Mar;35(Suppl 2):S32-S37

is a Fellow in the Division of Gastroenterology and Hepatology at University of North Carolina School of Medicine in Chapel Hill, North Carolina. is a Data Analyst for the HHRC Data and Analytics Group and Data Analyst for Health Services Research and Development at VA Puget Sound Healthcare System. is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration (VHA), Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Infectious Diseases Section at VA Portland Healthcare System in Oregon and an Assistant Professor in the Division of Infectious Diseases at Oregon Health and Sciences University in Portland. Dr. Maier is the National Public Health Infectious Disease Officer. is the Director of the HHRC National Hepatitis Resource Center; Chief, Gastroenterology at VA Long Beach Healthcare System in California; and Professor in the Division of Gastroenterology at University of California, Irvine. is National Program Manager for Prevention Policy at VHA National Center for Health Promotion and Disease Prevention in Durham, North Carolina.

Although widespread hepatitis A vaccination has dramatically decreased infection rates, a large proportion of VA patients in traditionally high-risk groups remains susceptible to infection. Read More

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Predictors of Ocular Surface Squamous Neoplasia and Conjunctival Squamous Cell Carcinoma among Ugandan Patients: A Hospital-based Study.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):150-155

Department of Ophthalmology, Mbarara University of Science and Technology and Ruharo Eye Centre, Mbarara, Uganda.

Aim: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients.

Materials And Methods: Patients presenting for removal of ocular surface lesions received human immunodeficiency virus (HIV) testing, completed questionnaires about demographic, behavioral, and historical potential risk factors for conjunctival neoplasia, and had lesions examined for interpalpebral versus other locations, rough versus smooth texture, and number of feeder vessels. Biopsies were classified pathologically using standard definitions classified OSSN and SCC. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_187_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348942PMC
February 2019

Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C Related Decompensated Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):4-12. Epub 2018 Mar 6.

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Background: Sofosbuvir (SOF), a direct acting antiviral, has revolutionized the treatment of chronic Hepatitis C Virus (HCV) infection. However, data is scarce about efficacy of SOF plus Ribavarin (RBV) in Indian patients with decompensated cirrhosis. We evaluated the efficacy of SOF plus RBV in decompensated cirrhosis, and compared the outcome with compensated cirrhosis and non-cirrhotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183004
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http://dx.doi.org/10.1016/j.jceh.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363947PMC
March 2018
2 Reads

Network controllability analysis of intracellular signalling reveals viruses are actively controlling molecular systems.

Sci Rep 2019 Feb 14;9(1):2066. Epub 2019 Feb 14.

Evolution and Genomic Sciences, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.

In recent years control theory has been applied to biological systems with the aim of identifying the minimum set of molecular interactions that can drive the network to a required state. However, in an intra-cellular network it is unclear how control can be achieved in practice. To address this limitation we use viral infection, specifically human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV), as a paradigm to model control of an infected cell. Read More

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http://www.nature.com/articles/s41598-018-38224-9
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http://dx.doi.org/10.1038/s41598-018-38224-9DOI Listing
February 2019
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Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors.

Sci Rep 2019 Feb 14;9(1):2117. Epub 2019 Feb 14.

Department of Parasitology, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096, Warsaw, Poland.

The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (B. burgdorferi s.l. Read More

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http://dx.doi.org/10.1038/s41598-019-38755-9DOI Listing
February 2019

HIV transmission networks among transgender women in Los Angeles County, CA, USA: a phylogenetic analysis of surveillance data.

Lancet HIV 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, University of California, San Diego, CA, USA.

Background: Transgender women are among the groups at highest risk for HIV infection, with a prevalence of 27·7% in the USA; and despite this known high risk, undiagnosed infection is common in this population. We set out to identify transgender women and their partners in a molecular transmission network to prioritise public health activities.

Methods: Since 2006, HIV protease and reverse transcriptase gene (pol) sequences from drug resistance testing have been reported to the Los Angeles County Department of Public Health and linked to demographic data, gender, and HIV transmission risk factor data for each case in the enhanced HIV/AIDS Reporting System. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30359-XDOI Listing
February 2019

Long term outcomes of patients transplanted for hepatocellular carcinoma with human immunodeficiency virus infection.

HPB (Oxford) 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery - Transplant Division, University of Kentucky, College of Medicine, Lexington, KY, USA. Electronic address:

Background: We aimed to study outcomes in HIV + patients with HCC in the US following Liver Transplantation (LT) using the UNOS dataset.

Methods: The database was queried from 2003 to 2016 for patients undergoing LT with HCC, HIV+, and HCC/HIV+.

Results: Out of 17,397 LT performed for HCC during the study period, 113 were transplanted for HCC with HIV infection (91 isolated livers). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.01.001DOI Listing
February 2019

An interview project with native American people: a community-based study to identify actionable steps to reduce health disparities.

Public Health 2019 Feb 12. Epub 2019 Feb 12.

Montana State University, Department of Health and Human Development, 318 Herrick Hall, Bozeman, MT, 59717, USA.

Objectives: The primary objective of this study was to work with tribal communities to define and develop their own healthcare services and strategies for positive change regarding injection drug use, human immunodeficiency virus (HIV), and hepatitis C virus (HCV) infection. The secondary objective of this study was to incorporate community capacity building strategies to develop and sustain programming and resources to optimize tribal communities' responsiveness to reduce health disparities.

Study Design: Semi-structured qualitative interviews. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.002DOI Listing
February 2019

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study.

Lancet 2019 Feb 11. Epub 2019 Feb 11.

AP-HP, Hôpital Cochin, Unité d'Hépatologie, Paris, France; Université Paris Descartes, INSERM U1223 and USM-20, Institut Pasteur, Paris, France.

Background: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort.

Methods: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32111-1DOI Listing
February 2019

Effect of ART scale-up and female migration intensity on risk of HIV acquisition: results from a population-based cohort in KwaZulu-Natal, South Africa.

BMC Public Health 2019 Feb 14;19(1):196. Epub 2019 Feb 14.

Africa Health Research Institute (AHRI), KwaZulu-Natal, South Africa.

Background: Despite increased antiretroviral therapy (ART) coverage, the incidence of HIV infection among women in rural South Africa remains high. While many socio-demographic and behavioral factors have been identified, the effect of female migration intensity on the risk of HIV acquisition before and after ART scale-up has not been evaluated in the country.

Methods: We followed 13,315 female participants aged 15-49 who were HIV-uninfected at baseline and recorded their migration events between 2004 and 2015. Read More

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http://dx.doi.org/10.1186/s12889-019-6494-xDOI Listing
February 2019

Determination of medication adherence and related factors among people living with HIV/AIDS in a Turkish university hospital

Turk J Med Sci 2019 Feb 11;49(1):198-205. Epub 2019 Feb 11.

Background/aim: Widespread use of antiretroviral treatment (ART) has led to decrease in the incidence of HIV/AIDS-related mortality. Besides the availability of ART, medication adherence is essential for treatment success. There is a scarcity of data reported from Turkey regarding ART adherence among people living with HIV/AIDS (PLWHA). Read More

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http://dx.doi.org/10.3906/sag-1802-137DOI Listing
February 2019

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018

HIV diagnoses in migrant populations in Australia-A changing epidemiology.

PLoS One 2019 14;14(2):e0212268. Epub 2019 Feb 14.

Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, Australia.

Introduction: We conducted a detailed analysis of trends in new HIV diagnoses in Australia by country of birth, to understand any changes in epidemiology, relationship to migration patterns and implications for public health programs.

Methods: Poisson regression analyses were performed, comparing the age-standardised HIV diagnosis rates per 100,000 estimated resident population between 2006-2010 and 2011-2015 by region of birth, with stratification by exposure (male-to-male sex, heterosexual sex-males and females). Correlation between the number of permanent and long-term arrivals was also explored using linear regression models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212268PLOS
February 2019

The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.

PLoS One 2019 14;14(2):e0212283. Epub 2019 Feb 14.

Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.

Objective: To investigate the association between current CD4+ T-cell count and CD4/CD8+ ratio with severity of frailty among people aging with HIV.

Methods: Cross-sectional observational study analysing data from all study visits in the ongoing prospective Modena HIV Metabolic Clinic Cohort between 2006 and 2015. Frailty severity was assessed using a frailty index (FI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212283PLOS
February 2019
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Mucosal cell populations may contribute to peripheral immune abnormalities in HIV-infected subjects introducing cART with moderate immune-suppression.

PLoS One 2019 14;14(2):e0212075. Epub 2019 Feb 14.

Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan, Italy.

HIV infection causes the progressive depletion of CD4+ T-lymphocytes and profound modifications of T-cell homeostasis, which persist despite virologically-suppressive treatment and have been linked to a worse clinical outcome. Enduring alterations of the gastrointestinal tract may represent the underlying pathogenic mechanisms of these phenomena. Twenty-six HIV-infected subjects were assessed over a 12-month period following the introduction of antiretroviral therapy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212075PLOS
February 2019

Transmission Patterns in a Low HIV-Morbidity State - Wisconsin, 2014-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):149-152. Epub 2019 Feb 15.

Public health interviews (i.e., partner services), during which persons with diagnosed human immunodeficiency virus (HIV) infection name their sexual or needle-sharing partners (named partners), are used to identify HIV transmission networks to guide and prioritize HIV prevention activities. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a5.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6806a5DOI Listing
February 2019
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Engagement in HIV Care and Access to Cancer Treatment Among Patients With HIV-Associated Malignancies in Uganda.

J Glob Oncol 2019 Feb(5):1-8

3 Fred Hutchinson Cancer Research Center, Seattle, WA.

Purpose: Health system constraints limit access to HIV and cancer treatment programs in sub-Saharan Africa. Limited access and continuity of care affect morbidity and mortality of patients with cancer and HIV. We assessed barriers in the care cascade of comorbid HIV and cancer. Read More

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http://dx.doi.org/10.1200/JGO.18.00187DOI Listing
February 2019