303,137 results match your criteria HIV Disease


Clinical Risk Factors Associated with Multidrug-Resistant Tuberculosis (MDR-TB) in Mali.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

University Clinical Research Center (UCRC)- SEREFO Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address:

Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.004DOI Listing
February 2019

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil.

Braz J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil; Universidade Federal da Bahia, Bahia, Departamento de Medicina, Salvador, BA, Brazil. Electronic address:

Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.

Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14138670183055
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http://dx.doi.org/10.1016/j.bjid.2018.12.002DOI Listing
February 2019
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Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil.

Epidemics 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, United Kingdom.

Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Read More

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http://dx.doi.org/10.1016/j.epidem.2019.02.002DOI Listing
February 2019

Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019

Mozambique's Community Antiretroviral Therapy Support Group Program: The Role of Social Relationships in Facilitating HIV/AIDS Treatment Retention.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

The Lewis Family Foundation, Boston, MA, USA.

The Community Antiretroviral (ARV) Therapy Support Group (CASG) program aims to address low retention rates in Mozambique's HIV treatment program and the absorptive capacity of the country's health facilities. CASG provides patients with the opportunity to form groups, whose members provide peer support and collect ARV medications on a rotating basis for one another. Based on the promising results in one province, a multi-site level evaluation followed. Read More

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http://dx.doi.org/10.1007/s10461-019-02419-6DOI Listing
February 2019

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer.

Cancer Immunol Immunother 2019 Feb 15. Epub 2019 Feb 15.

CureVac AG, Tübingen, Germany.

CV9201 is an RNActive-based cancer immunotherapy encoding five non-small cell lung cancer-antigens: New York esophageal squamous cell carcinoma-1, melanoma antigen family C1/C2, survivin, and trophoblast glycoprotein. In a phase I/IIa dose-escalation trial, 46 patients with locally advanced (n = 7) or metastatic (n = 39) NSCLC and at least stable disease after first-line treatment received five intradermal CV9201 injections (400-1600 µg of mRNA). The primary objective of the trial was to assess safety. Read More

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http://dx.doi.org/10.1007/s00262-019-02315-xDOI Listing
February 2019

Molecular epidemiology of acute HCV infection in HIV-positive patients from Hong Kong, Taipei, Tokyo.

Liver Int 2019 Feb 16. Epub 2019 Feb 16.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Acute hepatitis C virus (HCV) infections have been increasingly reported among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in the Asia-Pacific region. It remains unknown whether international network of HCV transmission has occurred in this region.

Methods: HIV-positive patients with acute HCV infection, defined as HCV seroconversion within a year or documented acute hepatitis with seroconversion, diagnosed in Hong Kong, Taipei, and Tokyo during 2010-2016 were included in this molecular epidemiology study. Read More

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http://doi.wiley.com/10.1111/liv.14073
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http://dx.doi.org/10.1111/liv.14073DOI Listing
February 2019
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Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy.

Ann Pharmacother 2019 Feb 15:1060028019833038. Epub 2019 Feb 15.

4 Massachusetts College of Pharmacy and Health Sciences University, School of Pharmacy, Worcester, MA, USA.

Objective: To describe data with selected malignancies in people living with HIV (PLWH) and HIV in individuals affected by both conditions and to summarize drug-drug interactions (DDIs) with clinical recommendations for point-of-care review of combination therapies.

Data Sources: Literature searches were performed (2005 to December 2018) in MEDLINE and EMBASE to identify studies of malignancies in PLWH in the modern era.

Study Selection And Data Extraction: Article bibliographies and drug interaction databases were reviewed. Read More

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http://dx.doi.org/10.1177/1060028019833038DOI Listing
February 2019

Assessment of voluntary HIV screening for asylum seekers in two Swiss cantons.

Swiss Med Wkly 2019 Feb 15;149:w20020. Epub 2019 Feb 15.

Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland / Departments of Infectious Diseases and of Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Objective: To evaluate the feasibility of HIV screening, offered to newly arrived asylum seekers in the Swiss cantons of Valais (VS) and Vaud (VD) in order to meet the national and international standards for early detection and effective treatment of HIV infections.

Methods: HIV screening was offered free of charge to every asylum seeker who arrived from June 2015 to November 2016 in VS, and from June to October 2016 in VD. Pregnant women and children <16 were excluded. Read More

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http://dx.doi.org/10.4414/smw.2019.20020DOI Listing
February 2019

Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

AP-HP, Hôpital Jean Verdier, Service d'Hépatologie, Bondy, Université Paris 13, Bobigny et INSERM U1162, Université Paris 5, Paris.

Background & Aims: Management of patients with cirrhosis includes endoscopic screening and surveillance to detect esophageal varices (EV) and prevent bleeding. However, the Baveno VI guidelines recommend avoiding endoscopies for patients with liver stiffness measurements below 20 kPa and platelet counts above 150,000 (favorable Baveno VI status) and endoscopic assessment of patients with higher levels of liver stiffness and platelet counts (unfavorable Baveno VI status). We aimed to validate the Baveno VI guidelines, evaluating outcomes of patients in the ANRS-CO12 CirVir cohort with compensated cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, with or without a sustained response to antiviral therapy. Read More

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http://dx.doi.org/10.1053/j.gastro.2018.11.053DOI Listing
February 2019

Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study.

J Int AIDS Soc 2019 Feb;22(2):e25223

Department of Human Development, State University of New York at BinghamtonBinghamton, NY, USA.

Introduction: Randomized clinical trials have demonstrated the efficacy of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV acquisition among men who have sex with men (MSM). However, limited research has examined initiation and adherence to PrEP among Black MSM (BMSM) in the United States (US) who are disproportionately represented among newly HIV infected and late to care individuals. This research reports on the HIV Prevention Trials Network 073 (HPTN 073) study aimed to examine PrEP initiation, utilization and adherence among Black MSM utilizing the theoretically principled, culturally informed and client-centered care coordination (C4) model. Read More

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http://dx.doi.org/10.1002/jia2.25223DOI Listing
February 2019
5.090 Impact Factor

Patterns and clinical consequences of discontinuing HIV preexposure prophylaxis during primary care.

J Int AIDS Soc 2019 Feb;22(2):e25250

Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Introduction: Discontinuations of HIV preexposure prophylaxis (PrEP) by at-risk individuals could decrease the effectiveness of PrEP. Our objective was to characterize patterns of, reasons for, and clinical outcomes associated with PrEP discontinuations in primary care.

Methods: We conducted medical chart reviews for patients prescribed PrEP during 2011 to 2014 at a Boston community health centre specializing in healthcare for sexual and gender minorities. Read More

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http://doi.wiley.com/10.1002/jia2.25250
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http://dx.doi.org/10.1002/jia2.25250DOI Listing
February 2019
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High plasma soluble CD163 during infancy is a marker for neurocognitive outcomes in early treated HIV-infected children.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Global Health, University of Washington, Seattle, WA, USA.

Background: Monocyte activation may contribute to neuronal injury in aviremic HIV-infected adults; data are lacking in children. We examined the relation between monocyte activation markers and early and long-term neurodevelopmental outcomes in early-treated HIV-infected children.

Setting: Prospective study of infant and child neurodevelopmental outcomes nested within a randomized clinical trial (NCT00428116) and extended cohort study in Kenya. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001979DOI Listing
February 2019
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Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019

Emotional Experiences of Mothers Living With HIV and the Quest for Emotional Recovery: A Qualitative Study in Lima, Peru.

J Assoc Nurses AIDS Care 2019 Feb 13. Epub 2019 Feb 13.

Carmen Contreras, BA, is Director of Intervention Projects, Socios En Salud, Partners In Health, Lima, Peru. Nancy Rumaldo, BA, is a Project Coordinator, Socios En Salud, Partners In Health, Lima, Peru. Michael Masao Lindeborg, BA, is an MD candidate, Harvard Medical School, Boston, Massachusetts, USA. Milagros Mendoza, BA, is a Project Manager, Socios En Salud, Partners In Health, Lima, Peru. David Roy Chen, BA, is an MD candidate, University of Washington School of Medicine, Seattle, Washington, USA. Olga Saldaña, RN, is a Field Coordinator, Socios En Salud, Partners In Health, Lima, Peru. Milagros Wong, RN, is a Project Manager, Socios En Salud, Partners In Health, Lima, Peru. Maribel Muñoz, RN, is a Project Manager, Socios En Salud Partners In Health, Lima, Peru. Elizabeth Schrier, BA, is a Research Assistant, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Leonid Lecca, MD, MPH, is a Lecturer on Global Health and Social Medicine, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA, and Executive Director of Socios En Salud, Partners In Health, Lima, Peru. Arachu Castro, PhD, MPH, is the Samuel Z. Stone Endowed Chair of Public Health in Latin America, Department of Global Community Health and Behavioral Sciences, and Director of the Collaborative Group for Health Equity in Latin America (CHELA), Tulane School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA. Sonya Sunhi Shin, MD, MPH, is an Associate Physician of Infectious Disease, Division of Global Health Equity at Brigham and Women's Hospital, Boston, Massachusetts, USA. Adrianne Katrina Nelson, MPH, Msc, is a Research Manager, Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Little evidence exists about the emotional experiences of mothers with HIV, and a better understanding is essential to support their emotional health and treatment adherence. We describe the emotional experiences of eight mothers who initiated antiretroviral therapy during pregnancy or within a few years of childbirth in Lima, Peru. An interpretive phenomenological approach was used, and the following themes emerged: (a) emotions involved in diagnosis and disclosure, (b) the meaning of motherhood with HIV, (c) the mothers' roles in seeking and maintaining relationships with partners and families, and (d) mechanisms for resilience and emotional recovery. Read More

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http://dx.doi.org/10.1097/JNC.0000000000000051DOI Listing
February 2019
1.228 Impact Factor

Plant-derived medicines for neuropathies: a comprehensive review of clinical evidence.

Rev Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.

Neuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies. Read More

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http://dx.doi.org/10.1515/revneuro-2018-0097DOI Listing
February 2019

The problem of lost to follow-up of mother-child pairs enrolled in the PMTCT program in Dschang District Hospital-Cameroon.

Ig Sanita Pubbl 2018 Jul-Aug;74(4):337-347

Department of Biomedical Sciences, Faculty of Science, University of Dschang, PO Box 67 Dschang, Cameroon.

High rates of lost to follow-up (LTFU) in the Prevention of Mother-To-Child Transmission of HIV (PMTCT) programs in Cameroon will only contribute in hindering the successful implementation of the program. The objective of this study was to determine the reasons of LTFU of mother-child pairs enrolled in the PMTCT program in Dschang District Hospital (DDH): Cameroon. Methods: A retrospective cohort study was carried out in HIV+ exposed children delivered in the DDH from1st Jan 2012 - 31st Dec 2014, who were greater than or equal to 18 months at the study period (1st August - 30th September 2016) and whose mothers were enrolled in the PMTCT program for at least 3 months. Read More

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February 2019

Advancing health equity through cross-cutting approaches to health-related stigma.

BMC Med 2019 Feb 15;17(1):40. Epub 2019 Feb 15.

Uganda Youth Coalition on Adolescent Sexual Reproductive Health Rights and HIV, Kampala, Uganda.

Health-related stigma remains a major barrier to improving health and well-being for vulnerable populations around the world. This collection on stigma research and global health emerged largely as a result of a 2017 meeting on the "The Science of Stigma Reduction" sponsored by the US National Institutes of Health (NIH). An overwhelming consensus at the meeting was reached. Read More

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http://dx.doi.org/10.1186/s12916-019-1282-0DOI Listing
February 2019

[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019

Correlates of Sexually Transmitted Infections Among South African Women Using Individual- and Community-Level Factors: Results from Generalized Additive Mixed Models.

Arch Sex Behav 2019 Feb 14. Epub 2019 Feb 14.

Biostatistics Unit, South African Medical Research Council, Durban, Kwazulu-Natal, South Africa.

South Africa has the highest burden of human immunodeficiency virus (HIV) infections in the world. There is also growing evidence that an individual's risk of contracting HIV is increased by the presence of other sexually transmitted infections (STIs). The primary objective of this study was to examine the association between the prevalence of STIs in a cohort of South African women who enrolled in HIV prevention trials (2002-2012). Read More

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http://dx.doi.org/10.1007/s10508-018-1315-3DOI Listing
February 2019

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

J Neurovirol 2019 Feb 14. Epub 2019 Feb 14.

Department of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1. Read More

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http://dx.doi.org/10.1007/s13365-019-00723-4DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019
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E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals.

Afr Health Sci 2018 Dec;18(4):1066-1075

Division of Chemical Pathology, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.

Background: E-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.

Objectives: This study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354867PMC
December 2018

Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria.

Afr Health Sci 2018 Dec;18(4):1057-1065

Virology Unit, Department of Microbiology, University of Ilorin, P.M.B 1515 Ilorin-Nigeria.

Background: Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals.

Objectives: This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354892PMC
December 2018

Achieving Excellence in Hepatitis B Virus Care for Veterans in the Veterans Health Administration.

Fed Pract 2018 Mar;35(Suppl 2):S49-S53

is Director and is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration (VHA) Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). is the Director of the HHRC National Hepatitis Resource Center; Chief, Gastroenterology at VA Long Beach Healthcare System in California; and Professor in the Division of Gastroenterology at University of California, Irvine. is a Data Analyst for the HHRC Data and Analytics Group and Data Analyst for Health Services Research and Development at VA Puget Sound Healthcare System. is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Infectious Diseases Section at the VA Portland Healthcare System and an Assistant Professor at Oregon Health and Sciences University in the Division of Infectious Diseases, both in Portland. is National Program Manager for Prevention Policy at VHA National Center for Health Promotion and Disease Prevention in Durham, North Carolina.

Enhancing care of veterans infected with hepatitis B virus who are in VHA care includes providing clinical guidance, informatics tools, patient monitoring, and continuous evaluation of care. Read More

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Accessibility and Uptake of Pre-Exposure Prophylaxis for HIV Prevention in the Veterans Health Administration.

Fed Pract 2018 Mar;35(Suppl 2):S42-S48

is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration, Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). and are Data Analysts for the HHRC Data and Analytics Group and Data Analysts for the Health Services Research and Development at VA Puget Sound Healthcare System. is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Geriatric Research Education and Clinical Center, Division of Infectious Diseases at Louis Stokes Cleveland VAMC and an Assistant Professor in the Department of Internal Medicine, Division of Infectious Diseases at Case Western Reserve University School of Medicine, both in Cleveland, Ohio. is an Investigator at the Center for Access and Delivery Research and Evaluation at Iowa City VA Health Care System and an Associate Professor in the University of Iowa Department of Medicine. is a staff physician in the Infectious Diseases Section of the VA Portland Healthcare System and an Assistant Professor, at Oregon Health and Sciences University in the Division of Infectious Diseases, both in Portland.

To increase access, the National PrEP Working Group is expanding outreach outside of primary care and among nonspecialists, ensuring uniformly high-quality care and targeting high-risk populations. Read More

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Hepatitis A Virus Prevention and Vaccination Within and Outside the Veterans Health Administration in Light of Recent Outbreaks.

Fed Pract 2018 Mar;35(Suppl 2):S32-S37

is a Fellow in the Division of Gastroenterology and Hepatology at University of North Carolina School of Medicine in Chapel Hill, North Carolina. is a Data Analyst for the HHRC Data and Analytics Group and Data Analyst for Health Services Research and Development at VA Puget Sound Healthcare System. is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration (VHA), Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Infectious Diseases Section at VA Portland Healthcare System in Oregon and an Assistant Professor in the Division of Infectious Diseases at Oregon Health and Sciences University in Portland. Dr. Maier is the National Public Health Infectious Disease Officer. is the Director of the HHRC National Hepatitis Resource Center; Chief, Gastroenterology at VA Long Beach Healthcare System in California; and Professor in the Division of Gastroenterology at University of California, Irvine. is National Program Manager for Prevention Policy at VHA National Center for Health Promotion and Disease Prevention in Durham, North Carolina.

Although widespread hepatitis A vaccination has dramatically decreased infection rates, a large proportion of VA patients in traditionally high-risk groups remains susceptible to infection. Read More

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Integrating Care for Patients With Chronic Liver Disease and Mental Health and Substance Use Disorders.

Fed Pract 2018 Mar;35(Suppl 2):S14-S23

is an Assistant Professor and is a Resident at University of Pittsburgh in Pennsylvania. is a Gastroenterologist at Baylor Scott & White Health, Texas. is a Health Communications Researcher at the Center for Healthcare Organization and Implementation Research at Bedford VAMC in Massachusetts. is the Deputy Director and the National Infectious Diseases Officer and Ms. Maguire is Communications Lead at the Veterans Health Administration, Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs. Dr. Rogal is a Gastroenterologist, Transplant Hepatologist, and an Investigator at the Center for Health Equity Research and Promotion at VA Pittsburgh Healthcare System.

Mental health disorders are common among patients with chronic liver disease, and current literature supports the use of better screening and providing integrated or multidisciplinary care where possible. Read More

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Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C Related Decompensated Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):4-12. Epub 2018 Mar 6.

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Background: Sofosbuvir (SOF), a direct acting antiviral, has revolutionized the treatment of chronic Hepatitis C Virus (HCV) infection. However, data is scarce about efficacy of SOF plus Ribavarin (RBV) in Indian patients with decompensated cirrhosis. We evaluated the efficacy of SOF plus RBV in decompensated cirrhosis, and compared the outcome with compensated cirrhosis and non-cirrhotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183004
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http://dx.doi.org/10.1016/j.jceh.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363947PMC
March 2018
2 Reads

Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors.

Sci Rep 2019 Feb 14;9(1):2117. Epub 2019 Feb 14.

Department of Parasitology, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096, Warsaw, Poland.

The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (B. burgdorferi s.l. Read More

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http://dx.doi.org/10.1038/s41598-019-38755-9DOI Listing
February 2019

HIV transmission networks among transgender women in Los Angeles County, CA, USA: a phylogenetic analysis of surveillance data.

Lancet HIV 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, University of California, San Diego, CA, USA.

Background: Transgender women are among the groups at highest risk for HIV infection, with a prevalence of 27·7% in the USA; and despite this known high risk, undiagnosed infection is common in this population. We set out to identify transgender women and their partners in a molecular transmission network to prioritise public health activities.

Methods: Since 2006, HIV protease and reverse transcriptase gene (pol) sequences from drug resistance testing have been reported to the Los Angeles County Department of Public Health and linked to demographic data, gender, and HIV transmission risk factor data for each case in the enhanced HIV/AIDS Reporting System. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30359-XDOI Listing
February 2019

Long term outcomes of patients transplanted for hepatocellular carcinoma with human immunodeficiency virus infection.

HPB (Oxford) 2019 Feb 11. Epub 2019 Feb 11.

Department of Surgery - Transplant Division, University of Kentucky, College of Medicine, Lexington, KY, USA. Electronic address:

Background: We aimed to study outcomes in HIV + patients with HCC in the US following Liver Transplantation (LT) using the UNOS dataset.

Methods: The database was queried from 2003 to 2016 for patients undergoing LT with HCC, HIV+, and HCC/HIV+.

Results: Out of 17,397 LT performed for HCC during the study period, 113 were transplanted for HCC with HIV infection (91 isolated livers). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.01.001DOI Listing
February 2019

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study.

Lancet 2019 Feb 11. Epub 2019 Feb 11.

AP-HP, Hôpital Cochin, Unité d'Hépatologie, Paris, France; Université Paris Descartes, INSERM U1223 and USM-20, Institut Pasteur, Paris, France.

Background: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort.

Methods: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32111-1DOI Listing
February 2019

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease.

Microbiome 2019 Feb 14;7(1):25. Epub 2019 Feb 14.

Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Ave. BSB208D, Charleston, SC, 29425, USA.

Background: Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown.

Results: Herein, we show that seasonal influenza vaccination induces autoantibody production (e.g. Read More

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http://dx.doi.org/10.1186/s40168-019-0646-1DOI Listing
February 2019
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The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas.

BMC Med 2019 Feb 15;17(1):31. Epub 2019 Feb 15.

Yale University, New Haven, CT, USA.

Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitigate the harmful consequences of health-related stigma (i.e. Read More

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http://dx.doi.org/10.1186/s12916-019-1271-3DOI Listing
February 2019

A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries.

BMC Med 2019 Feb 15;17(1):17. Epub 2019 Feb 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Background: Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. However, the literature discussing the relationship between stigma and health outcomes is largely fragmented within disease-specific siloes, thus limiting the identification of common moderators or mechanisms through which stigma potentiates adverse health outcomes as well as the development of broadly relevant stigma mitigation interventions.

Methods: We conducted a scoping review to provide a critical overview of the breadth of research on stigma for each of the five aforementioned conditions in LMICs, including their methodological strengths and limitations. Read More

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http://dx.doi.org/10.1186/s12916-019-1250-8DOI Listing
February 2019

Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention.

BMC Med 2019 Feb 15;17(1):13. Epub 2019 Feb 15.

College of Global Public Health, New York University, New York, NY, USA.

Background: Many health conditions perceived to be contagious, dangerous or incurable, or resulting in clearly visible signs, share a common attribute - an association with stigma and discrimination. While the etiology of stigma may differ between conditions and, sometimes, cultural settings, the manifestations and psychosocial consequences of stigma and discrimination are remarkably similar. However, the vast majority of studies measuring stigma or addressing stigma through interventions employ a disease-specific approach. Read More

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http://dx.doi.org/10.1186/s12916-018-1245-xDOI Listing
February 2019

Stigma in health facilities: why it matters and how we can change it.

BMC Med 2019 Feb 15;17(1):25. Epub 2019 Feb 15.

Centre for Longitudinal & Life Course Studies, University of Antwerp, Sint-Jacobstraat 2, B-2000, Antwerp, Belgium.

Stigma in health facilities undermines diagnosis, treatment, and successful health outcomes. Addressing stigma is fundamental to delivering quality healthcare and achieving optimal health. This correspondence article seeks to assess how developments over the past 5 years have contributed to the state of programmatic knowledge-both approaches and methods-regarding interventions to reduce stigma in health facilities, and explores the potential to concurrently address multiple health condition stigmas. Read More

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http://dx.doi.org/10.1186/s12916-019-1256-2DOI Listing
February 2019

Effect of ART scale-up and female migration intensity on risk of HIV acquisition: results from a population-based cohort in KwaZulu-Natal, South Africa.

BMC Public Health 2019 Feb 14;19(1):196. Epub 2019 Feb 14.

Africa Health Research Institute (AHRI), KwaZulu-Natal, South Africa.

Background: Despite increased antiretroviral therapy (ART) coverage, the incidence of HIV infection among women in rural South Africa remains high. While many socio-demographic and behavioral factors have been identified, the effect of female migration intensity on the risk of HIV acquisition before and after ART scale-up has not been evaluated in the country.

Methods: We followed 13,315 female participants aged 15-49 who were HIV-uninfected at baseline and recorded their migration events between 2004 and 2015. Read More

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http://dx.doi.org/10.1186/s12889-019-6494-xDOI Listing
February 2019

Men's Refashioning of Masculine Identities in Uganda and Their Self-Management of HIV Treatment.

Authors:
Steve Russell

Qual Health Res 2019 Feb 14:1049732318823717. Epub 2019 Feb 14.

1 University of East Anglia, Norwich, United Kingdom.

Studies in sub-Saharan Africa show that masculine identities contribute to men's relatively lower uptake of HIV services. Although useful, these studies pay less attention to men's agency to negotiate and refashion masculine identities which better suit their lives as men living with HIV. In this article, I analyze the refashioning of masculine identities among men living with HIV in Uganda, adjustment processes which helped their self-management, and adherence to treatment. Read More

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http://dx.doi.org/10.1177/1049732318823717DOI Listing
February 2019

Determination of medication adherence and related factors among people living with HIV/AIDS in a Turkish university hospital

Turk J Med Sci 2019 Feb 11;49(1):198-205. Epub 2019 Feb 11.

Background/aim: Widespread use of antiretroviral treatment (ART) has led to decrease in the incidence of HIV/AIDS-related mortality. Besides the availability of ART, medication adherence is essential for treatment success. There is a scarcity of data reported from Turkey regarding ART adherence among people living with HIV/AIDS (PLWHA). Read More

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http://dx.doi.org/10.3906/sag-1802-137DOI Listing
February 2019

Prescription opioid misuse among middle-aged and older adults in the United States, 2015-2016.

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

Center for Drug Use and HIV/HCV Research, New York University Rory Meyers College of Nursing, 433 First Avenue, 7th Floor, New York, NY 10010, United States of America; New York University Langone Medical Center, Department of Population Health, 550 First Avenue, New York, NY 10016, United States of America.

Adults ≥50 years of age have high rates of prescription opioid use. The purpose of this study is to estimate the prevalence and correlates of prescription opioid misuse among middle-aged and older adults in the United States who use prescription opioids. Data from adults age ≥ 50 from the two most recent cohorts (2015 and 2016) of the National Survey of Drug Use and Health were examined (N = 17,608). Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.018DOI Listing
February 2019

[Laryngeal Tuberculosis Diagnosed in a Pathological Laboratory in Senegal (2011-2015)].

Bull Soc Pathol Exot 2018 ;111(1):5-8

Laboratoire d'anatomie et cytologie pathologiques, de l'hôpital Aristide-Le-Dantec, Dakar, Sénégal.

Laryngeal tuberculosis (LT) is a rare disease. The therapy for LT is easy but the diagnosis remains a challenge for the pathologist and the laryngologist because of the absence of specific signs. The objective was to analyze the epidemiological and pathological profiles of LT cases in Dakar (Senegal) with a view to better understand this pathology. Read More

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http://dx.doi.org/10.3166/bspe-2018-0010DOI Listing
January 2018

A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines.

PLoS One 2019 14;14(2):e0211695. Epub 2019 Feb 14.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département Biostatistique Santé Publique et Information Médicale, Unité de Recherche Clinique PSL-CFX, Centre de Pharmacoépidémiologie (Cephepi), Paris, France.

Background: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211695PLOS
February 2019

Trend and projection of mortality rate due to non-communicable diseases in Iran: A modeling study.

PLoS One 2019 14;14(2):e0211622. Epub 2019 Feb 14.

Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Background: Following the epidemiologic and demographic transition, non-communicable disease mortality is the leading cause of death in Iran. Projecting mortality trend can provide valuable tools for policy makers and planners. In this article, we have estimated the trend of non-communicable disease mortality during 2001-2015 and have projected it until 2030 at national and subnational levels in Iran. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211622PLOS
February 2019

Transmission Patterns in a Low HIV-Morbidity State - Wisconsin, 2014-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):149-152. Epub 2019 Feb 15.

Public health interviews (i.e., partner services), during which persons with diagnosed human immunodeficiency virus (HIV) infection name their sexual or needle-sharing partners (named partners), are used to identify HIV transmission networks to guide and prioritize HIV prevention activities. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a5.htm?s_cid=mm6
Publisher Site
http://dx.doi.org/10.15585/mmwr.mm6806a5DOI Listing
February 2019
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Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):144-148. Epub 2019 Feb 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806a4DOI Listing
February 2019

Research evidence on strategies enabling integration of electronic health records in the health care systems of low- and middle-income countries: A literature review.

Int J Health Plann Manage 2019 Feb 14. Epub 2019 Feb 14.

Carolina Health Informatics Program, University of North Carolina at Chapel Hill, North Carolina, USA.

Integration of electronic health records (EHRs) in the national health care systems of low- and middle-income countries (LMICs) is vital for achieving the United Nations Sustainable Development Goal of ensuring healthy lives and promoting well-being for all people of all ages. National EHR systems are increasing, but mostly in developed countries. Besides, there is limited research evidence on successful strategies for ensuring integration of national EHRs in the health care systems of LMICs. Read More

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http://dx.doi.org/10.1002/hpm.2754DOI Listing
February 2019

The prevalence of Mycoplasma genitalium and association with HIV infection in symptomatic patients, Johannesburg, South Africa, 2007-2014.

Sex Transm Dis 2019 Feb 11. Epub 2019 Feb 11.

Centre for HIV & STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.

Background: Mycoplasma genitalium is associated with genital discharge syndrome, but limited prevalence data is available in South Africa. The prevalence rates of M. genitalium infection and HIV co-infection were determined in urogenital specimens collected from male and female patients presenting with genital discharge syndrome to a primary health care centre in Johannesburg, South Africa from 2007 through 2014. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000984DOI Listing
February 2019
1 Read