72 results match your criteria HACEK Group Infections


Aortocavitary fistula secondary to vegetative endocarditis in a rabbit.

J Vet Cardiol 2019 Feb 13;21:49-56. Epub 2018 Dec 13.

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706, USA.

A 4-year-old intact male mini lop rabbit (Oryctolagus cuniculus) was presented with a 2-week history of severe progressive lethargy. A right parasternal continuous heart murmur and an irregular rhythm were detected on physical examination. Echocardiography identified vegetative aortic and tricuspid valve (TV) endocarditis. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.08.003DOI Listing
February 2019
1 Read

Native valve endocarditis due to Escherichia coli infection: a case report and review of the literature.

BMC Cardiovasc Disord 2018 10 19;18(1):195. Epub 2018 Oct 19.

Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Infective endocarditis due to Escherichia coli is a rare disease but is increasing in frequency, especially among older women. In addition, its mortality rate is higher than that of endocarditis due to the HACEK-group gram-negative bacteria (Haemophilus spp., Aggregatibacter spp. Read More

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http://dx.doi.org/10.1186/s12872-018-0929-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194693PMC
October 2018
4 Reads

HACEK infective endocarditis: Epidemiology, clinical features, and outcome: A case-control study.

Int J Infect Dis 2018 Nov 25;76:120-125. Epub 2018 Aug 25.

Infectious Diseases Service, Hospital Clinic - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. Electronic address:

Objectives: The study aimed to describe the epidemiological, microbiological, and clinical features of a population sample of 17 patients with HACEK infective endocarditis (HACEK-IE) and to compare them with matched control patients with IE caused by viridans group streptococci (VGS-IE).

Methods: Cases of definite (n=14, 82.2%) and possible (n=3, 17. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.08.013DOI Listing
November 2018
7 Reads
2.330 Impact Factor

Infective endocarditis: Surgical management and prognostic predictors.

Rev Port Cardiol 2018 May 3;37(5):387-394. Epub 2018 May 3.

Serviço de Cardiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.

Introduction And Aim: Infective endocarditis (IE) is associated with high morbidity and mortality. It is important to determine which factors increase the risk of poor outcome in order to enable early detection and aggressive treatment, including surgery. The aim of our study was to identify factors predicting complications and in-hospital mortality in patients with IE and to analyze conditions predisposing to surgery and its outcome. Read More

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http://dx.doi.org/10.1016/j.repc.2017.08.007DOI Listing
May 2018
3 Reads

Whole-Genome Sequencing of Aggregatibacter Species Isolated from Human Clinical Specimens and Description of Aggregatibacter kilianii sp. nov.

J Clin Microbiol 2018 07 25;56(7). Epub 2018 Jun 25.

Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark

species are commensal bacteria of human mucosal surfaces that are sometimes involved in serious invasive infections. During the investigation of strains cultured from various clinical specimens, we encountered a coherent group of 10 isolates that could not be allocated to any validly named species by phenotype, mass spectrometry, or partial 16S rRNA gene sequencing. Whole-genome sequencing revealed a phylogenetic cluster related to but separate from The mean DNA hybridization value for strains of the new cluster versus was 56% (range, 53. Read More

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http://dx.doi.org/10.1128/JCM.00053-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018338PMC
July 2018
7 Reads

Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study.

Int J Infect Dis 2018 Mar 1;68:83-87. Epub 2018 Feb 1.

Department of Clinical Microbiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address:

Objectives: Bacteria with common microbiological and clinical characteristics are often recognized as a particular group. The acronym HACEK stands for five fastidious genera associated with infective endocarditis (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella). Data on the epidemiology of HACEK are sparse. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.01.025DOI Listing
March 2018
8 Reads

Risk Factors and Outcomes of Endocarditis Due to Non-HACEK Gram-Negative Bacilli: Data from the Prospective Multicenter Italian Endocarditis Study Cohort.

Antimicrob Agents Chemother 2018 04 27;62(4). Epub 2018 Mar 27.

ASST Papa Giovanni XXIII, Infectious Diseases, Bergamo, Italy.

The objective of this study was to investigate predisposing factors and outcomes of infective endocarditis (IE) caused by non-HACEK Gram-negative bacilli (GNB) in a contemporary multicenter cohort. Patients with IE due to GNB, prospectively observed in 26 Italian centers from 2004 to 2011, were analyzed. Using a case-control design, each case was compared to three age- and sex-matched controls with IE due to other etiologies. Read More

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http://dx.doi.org/10.1128/AAC.02208-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913980PMC
April 2018
27 Reads

Particular surgical aspects of endocarditis due to Kingella kingae with cerebral complication.

Interact Cardiovasc Thorac Surg 2018 05;26(5):885-887

Department of Pediatric Cardiac Surgery, Necker Enfants Malades Hospital, Paris, France.

We report 2 cases of Kingella kingae endocarditis leading to valvular mitral perforation in previously healthy children. Kingella kingae belongs to the HACEK (Haemophilus aphrophilus, Actiobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and K. kingae) group of organisms known to cause endocarditis. Read More

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http://dx.doi.org/10.1093/icvts/ivx411DOI Listing
May 2018
10 Reads

[Endocarditis of mitral and aortic prosthetic heart valves caused by Aggregatibacter aphrophilus].

Rev Med Liege 2017 Dec;72(12):522-528

Service des Maladies infectieuses et Immunologie, Médecine interne générale, CHU de Liège, Site Sart Tilman, Liège, Belgique.

We present the case of an acute endocarditis of mitral and aortic prosthetic heart valves caused by Aggregatibacter aphrophilus (Haemophilus aphrophilus-paraphrophilus). This third report in the literature emphasizes the diagnostic work-up and the role of positron emission tomography combined with computed tomography in this setting. The specificities of endocarditis due to the HACEK group (Haemophilus spp. Read More

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December 2017
7 Reads

An unusual agent for an unusual localization of infective endocarditis.

Perfusion 2017 Nov 3;32(8):691-694. Epub 2017 Jun 3.

1 Department of Neurology, RWTH Aachen University, Aachen, Germany.

We report on a 32-year-old male patient with acute left-hemispheric stroke caused by embolism due to infective endocarditis affected from the HACEK group. Additionally, atypical findings from the transesophageal echocardiography (TEE) which showed fluttering structures belonging to the papillary muscle could be proven as infectious agents with the help of a glucose positron emission tomography (PET) scan. TEE controls showed increasing vegetation involving the mitral valve so that surgery became necessary. Read More

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http://dx.doi.org/10.1177/0267659117712406DOI Listing
November 2017
10 Reads

[Cardiobacterium hominis pericarditis: an unusual case].

Rev Chilena Infectol 2016 Dec;33(6):691-695

Nefrología, Instituto de Medicina, Universidad Austral de Chile, Chile.

The case of a male patient under hemodialytic therapy, who developed right heart failure is presented. Echocardiography revealed pericardial effusion, constrictive pattem in the right cavities, septation, without valvular damage and preserved systolic and diastolic function. Pericardial drainage and extensive pericardiectomy was performed obtaining cultures of pericardial tissue positive for an HACEK group organism, Cardiobacterium hominis, with repeatedly negative blood cultures. Read More

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http://dx.doi.org/10.4067/S0716-10182016000600013DOI Listing
December 2016
10 Reads

Ischemic Stroke and Septic Shock After Subacute Endocarditis Caused by : Case Report.

J Clin Med Res 2017 Jan 24;9(1):71-73. Epub 2016 Nov 24.

Intensive Therapy Division, Department of Surgery and Anatomy, University Hospital, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

, which belongs to the HACEK (, , , , and ) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. A 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. Physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. Read More

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http://dx.doi.org/10.14740/jocmr2703wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127219PMC
January 2017
26 Reads

Bartholinitis due to Aggregatibacter aphrophilus: a case report.

BMC Infect Dis 2016 Oct 18;16(1):574. Epub 2016 Oct 18.

Department of Bacteriology, Amiens University Hospital, Amiens, France.

Background: Aggregatibacter aphrophilus, a commensal of the oro-pharyngeal flora and member of the HACEK group of organisms, is an uncommonly encountered clinical pathogen. It has already been described as the causative agent of brain abscesses, empyema, meningitis, sinusitis, otitis media, bacteriemia, pneumonia, osteomyelitis, peritonitis, endocarditis and wound infections. Herein we report the first case of bartholinitis due to A. Read More

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http://dx.doi.org/10.1186/s12879-016-1908-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070192PMC
October 2016
10 Reads

Atypical presentation of infective endocarditis.

R I Med J (2013) 2016 Jul 1;99(7):24-6. Epub 2016 Jul 1.

Clinical Instructor in Medicine, Department of Internal Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

The HACEK group of organisms are one of the infrequent causes of infective endocarditis. Infective endocarditis should be recognized and treated promptly to prevent excessive morbidity and mortality associated with the disease. Sometimes the diagnosis is delayed due to vague and subtle presentation. Read More

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July 2016
4 Reads

An approach to a patient with infective endocarditis.

S Afr Med J 2016 Feb;106(2):145-50

Although infective endocarditis (IE) is relatively uncommon, it remains an important clinical entity with a high in-hospital and 1-year mortality. It is most commonly caused by viridans streptococci. Staphylococcus aureus is responsible for a malignant course of IE and often requires early surgery to eradicate. Read More

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February 2016
68 Reads

HACEK endocarditis: a review.

Expert Rev Anti Infect Ther 2016 06 17;14(6):539-45. Epub 2016 May 17.

b Division of Infectious Diseases, Department of Internal Medicine , American University of Beirut Medical Center , Beirut , Lebanon.

Introduction: The HACEK group, referring to Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae, is a rare cause of infective endocarditis (IE). It causes the majority of Gram-negative endocarditis cases and has an excellent prognosis and simple management if properly identified. Read More

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http://dx.doi.org/10.1080/14787210.2016.1184085DOI Listing
June 2016
17 Reads

HACEK endocarditis: state-of-the-art.

Expert Rev Anti Infect Ther 2016 28;14(5):523-30. Epub 2016 Mar 28.

a Infectious Diseases and Intensive Care Unit , Pontchaillou University Hospital , Rennes , France.

The HACEK group of bacteria - Haemophilus parainfluenzae, Aggregatibacter spp. (A. actinomycetemcomitans, A. Read More

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http://dx.doi.org/10.1586/14787210.2016.1164032DOI Listing
December 2016
41 Reads
2 Citations
3.461 Impact Factor

Endocarditis due to gram-negative bacilli at a French teaching hospital over a 6-year period: clinical characteristics and outcome.

Infect Dis (Lond) 2015 11;47(12):889-95. Epub 2015 Aug 11.

a From the Service de Maladies Infectieuses et Tropicales, AP-HP, Hôpital Bichat-Claude Bernard , Paris , France.

Background: Infective endocarditis (IE) due to gram-negative bacilli (GNB) is rare. However, several studies described a change in the epidemiological profile of patients within the past few years.

Methods: We reviewed all cases diagnosed and followed in the infectious diseases ward of a French teaching hospital in Paris between 2009 and 2014, inclusive. Read More

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July 2016
81 Reads

Subacute bacterial endocarditis caused by Cardiobacterium hominis: A case report.

Can J Infect Dis Med Microbiol 2015 Jan-Feb;26(1):41-3

Section of Infectious Diseases, Department of Medicine, University of Calgary, Calgary, Alberta.

Cardiobacterium hominis, a member of the HACEK group of organisms, is an uncommon but important cause of subacute bacterial endocarditis. First-line therapy is a third-generation cephalosporin due to rare beta-lactamase production. The authors report a case involving endovascular infection due to C hominis that initially tested resistant to third-generation cephalosporins using an antibiotic gradient strip susceptibility method (nitrocephin negative), but later proved to be susceptible using broth microdilution reference methods (a 'major' error). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353269PMC
March 2015
16 Reads
0.490 Impact Factor

Recurrent infective endocarditis due to Aggregatibacter aphrophilus and Staphylococcus lugdunensis.

Klin Padiatr 2015 Mar 9;227(2):89-92. Epub 2015 Mar 9.

Hospital Universitario Virgen del Rocío, Pediatric Infectious Diseases and Immunopathology, Seville, Spain.

Uncommon microorganisms are increasingly being recognized as causative agents of paediatric infectious endocarditis (IE). We report a 4-year old girl with congenital heart disease, who suffered from 2 IE episodes secondary to Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus) and Staphylococcus lugdunensis, both rarely reported pathogens in this age group. The patient was initially successfully treated with prolonged intravenous antibiotic courses, however removal of the Contegra valved conduit during the second episode was required due to recurrence of fever and development of pulmonary embolism despite completion of antibiotic therapy. Read More

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http://dx.doi.org/10.1055/s-0034-1398536DOI Listing
March 2015
5 Reads

Presumed Aggregatibacter aphrophilus endogenous endophthalmitis.

Int Ophthalmol 2015 Apr 14;35(2):269-73. Epub 2015 Feb 14.

Department of Ophthalmology, United Christian Hospital, Kowloon, Hong Kong SAR, China.

We hereby report a case of endogenous endophthalmitis, presumably caused by a rare culprit-Aggregatibacter aphrophilus. A. aphrophilus is a member of the HACEK group, a group of fastidious Gram-negative bacteria with low pathogenicity and a rare cause of human infections. Read More

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http://dx.doi.org/10.1007/s10792-015-0044-zDOI Listing
April 2015
6 Reads

Aggregatibacter aphrophilus pacemaker endocarditis: a case report.

BMC Res Notes 2014 Dec 8;7:885. Epub 2014 Dec 8.

Department of Internal Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

Background: Aggregatibacter bacteria are a rare cause of endocarditis in adults. They are part of a group of organisms known as HACEK--Haemophilus, Aggregatibacter, Cardiobacter, Eikenella, and Kingella. Among these organisms, several Haemophilus species have been reclassified under the genus Aggregatibacter. Read More

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http://dx.doi.org/10.1186/1756-0500-7-885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295285PMC
December 2014
14 Reads

Aggregatibacter actinomycemcomitans pneumonia in children: two case reports and a review of the literature.

Pediatr Infect Dis J 2015 Jan;34(1):100-2

From the *Pediatric Department A; †Bruce-Rappaport Faculty of Medicine Technion, Israel Institute of Technology; ‡Pediatric Infectious Diseases Unit; and §Pediatric Pulmonology Unit, Rambam Health Care Campus Haifa, Israel.

Aggregatibacter actinomycemcomitans, previously named Actinobacillus actinomycetemcomitans (Aa), is a facultative Gram-negative slow-growing coccobacillus associated with severe oral and nonoral infections. It is a member of the HACEK group. Pulmonary infection caused by Aa is rare. Read More

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http://dx.doi.org/10.1097/INF.0000000000000493DOI Listing
January 2015
23 Reads
2.723 Impact Factor

Association between HACEK bacteraemia and endocarditis.

J Med Microbiol 2014 Jun 28;63(Pt 6):892-5. Epub 2014 Mar 28.

Christchurch Hospital, Christchurch, New Zealand University of Otago, Christchurch, New Zealand

We retrospectively examined medical records of 87 patients with bacteraemia caused by members of the HACEK group (Haemophilus parainfluenzae, Aggregatibacter actinomycetemcomitans, Aggregatibacter aphrophilus, Aggregatibacter paraphrophilus, Cardiobacterium spp., Eikenella corrodens and Kingella spp.) to determine whether endocarditis was present, as defined by the Duke criteria. Read More

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http://dx.doi.org/10.1099/jmm.0.070060-0DOI Listing
June 2014
10 Reads

Permanent pacemaker-associated actinomycetemcomitans endocarditis: A case report.

Germs 2013 Sep 1;3(3):96-101. Epub 2013 Sep 1.

MD, Division of Infectious Disease, Department of Medicine, Nassau University Medical Center, East Meadow, New York, USA.

Aggregatibacter actinomycetemcomitans is a Gram-negative bacillus, member of the HACEK group of bacteria, and it is a very rare cause of endocarditis. It is also an extremely rare cause of device-associated infection of the heart. We describe the case of a 25 year-old man who presented with pacemaker-associated endocarditis due to Aggregatibacter actinomycetemcomitans and also discuss the implications and treatment of this organism. Read More

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http://dx.doi.org/10.11599/germs.2013.1043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882861PMC
September 2013
7 Reads

Cardiobacterium hominis-induced acute dacryocystitis and lacrimal abscess.

Indian J Ophthalmol 2014 Apr;62(4):495-7

Department of Ophthalmic Plastics, Kallam Anji Reddy Campus, L.V Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India.

Cardiobacterium hominis is a member of the HACEK (Haemophilus sp., Actinobacillus actinomycetemcomitans, C. hominis, Eikenella corrodens, and Kingella kingae) group commonly associated with endocarditits and is normally present in the respiratory tract. Read More

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http://dx.doi.org/10.4103/0301-4738.116461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064233PMC
April 2014
10 Reads

[A case of cerebral embolism caused by Cardiobacterium hominis endocarditis].

Rinsho Shinkeigaku 2013 ;53(8):654-7

Department of Neurology, Kumamoto University, Japan.

A 45-year-old woman was referred to our hospital by ambulance with left-sided palsy presented at dinner. Diffusion-weighted magnetic resonance imaging (DWI) showed a somewhat high intensity area in the right frontal lobe, and brain magnetic resonance angiography (MRA) revealed right middle cerebral artery (MCA) occlusion in the M1 distal segment. Although intravenous rt-PA treatment was initiated at 2 hours and 10 minutes after onset, recanalization was not achieved. Read More

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April 2014
4 Reads

Antimicrobial susceptibilities of clinical isolates of HACEK organisms.

Antimicrob Agents Chemother 2013 Apr 12;57(4):1989-91. Epub 2013 Feb 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

The "HACEK" organisms are a group of fastidious Gram-negative bacteria that cause a variety of infections, including infective endocarditis. Antimicrobial susceptibility testing is not universally available, and therapy for these infections is often empirical. We report the antimicrobial susceptibilities of 70 clinical HACEK isolates to 18 antimicrobials. Read More

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http://dx.doi.org/10.1128/AAC.00111-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623346PMC
April 2013
2 Reads

Infective endocarditis due to Enterobacter cloacae resistant to third- and fourth-generation cephalosporins.

J Microbiol Immunol Infect 2015 Apr 25;48(2):226-8. Epub 2012 Sep 25.

Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan.

We report the case of using a long-term combination of meropenem and amikacin to treat infective endocarditis caused by Enterobacter cloacae resistant to third- and fourth-generation cephalosporins. Multi-drug resistant Gram-negative bacilli, such as the E. cloacae in our study, may become possible pathogens of infective endocarditis. Read More

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http://dx.doi.org/10.1016/j.jmii.2012.07.015DOI Listing
April 2015
12 Reads

Haemophilus aphrophilus associated spleen abscess: an unusual presentation of subacute endocarditis.

J Clin Med Res 2012 Jun 15;4(3):209-11. Epub 2012 May 15.

Department of Internal Medicine, Changhua Christian Hospital, Changhua City, Taiwan.

The HACEK group of bacteria (Haemophilus spp., Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella spp.), is uncommon pathogens of infective endocarditis, but can cause life-threatening events such as heart failure or formation of lethal emboli. Read More

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http://dx.doi.org/10.4021/jocmr803wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376880PMC
June 2012
5 Reads

Endocarditis in a large district general hospital: A study of the microbiological spectrum between 2000 and 2011.

Exp Clin Cardiol 2012 ;17(4):175-8

Aintree University Hospitals National Health Services Foundation, Liverpool;

Infective endocarditis is one of three common cardiac infections in the United Kingdom, in addition to myocarditis and pericarditis, with a reported incidence of 1.7 to 6.2 cases per 100,000 patient years. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627269PMC
April 2013
17 Reads

High frequency of Tropheryma whipplei in culture-negative endocarditis.

J Clin Microbiol 2012 Feb 30;50(2):216-22. Epub 2011 Nov 30.

Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

"Classical" Whipple's disease (cWD) is caused by Tropheryma whipplei and is characterized by arthropathy, weight loss, and diarrhea. T. whipplei infectious endocarditis (TWIE) is rarely reported, either in the context of cWD or as isolated TWIE without signs of systemic infection. Read More

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http://dx.doi.org/10.1128/JCM.05531-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264169PMC
February 2012
4 Reads

Infective endocarditis in a child caused by Cardiobacterium hominis after right ventricular outflow tract reconstruction using an expanded tetrafluoroethylene conduit.

Gen Thorac Cardiovasc Surg 2011 Jun 15;59(6):429-32. Epub 2011 Jun 15.

Division of Cardiovascular Surgery, Nagano Children's Hospital, 3100 Toyoshina, Azumino, Nagano 399-8288, Japan.

Cardiobacterium hominis, a member of the HACEK group of organisms, is a rare cause of endocarditis. We report a case of infective endocarditis caused by C. hominis in a male child who had undergone right ventricular outflow tract (RVOT) reconstruction using an expanded polytetrafluoroethylene conduit for tetralogy of Fallot with pulmonary atresia. Read More

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http://link.springer.com/10.1007/s11748-010-0707-7
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http://dx.doi.org/10.1007/s11748-010-0707-7DOI Listing
June 2011
4 Reads

Subtle bacterial endocarditis due to Kingella kingae in an infant: a case report.

Cardiol Young 2010 Aug 14;20(4):448-50. Epub 2010 May 14.

Department of Pediatric Cardiology and Congenital heart Diseases, Cardiovascular Hospital Louis Pradel and Claude Bernard Lyon-1 University, Lyon, France.

A 9-month-old infant presented with fever, dyspnoea, and a murmur. Echocardiography showed a mitral vegetation with significant regurgitation. Mitral valve plasty was performed on day 6, and was polymerase chain reaction positive for Kingella kingae. Read More

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http://dx.doi.org/10.1017/S1047951110000351DOI Listing
August 2010
4 Reads

High-throughput identification of bacteria and yeast by matrix-assisted laser desorption ionization-time of flight mass spectrometry in conventional medical microbiology laboratories.

J Clin Microbiol 2010 Mar 6;48(3):900-7. Epub 2010 Jan 6.

Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands.

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is suitable for high-throughput and rapid diagnostics at low costs and can be considered an alternative for conventional biochemical and molecular identification systems in a conventional microbiological laboratory. First, we evaluated MALDI-TOF MS using 327 clinical isolates previously cultured from patient materials and identified by conventional techniques (Vitek-II, API, and biochemical tests). Discrepancies were analyzed by molecular analysis of the 16S genes. Read More

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http://dx.doi.org/10.1128/JCM.02071-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832429PMC
March 2010
27 Reads

Complications of infective endocarditis.

Cardiovasc Hematol Disord Drug Targets 2009 Dec;9(4):240-8

Lancisi Heart Hospital, Ospedali Riuniti Umberto 1o, Lancisi, Salesi, Ancona, Italy.

Infective endocarditis (IE) is a lethal disease if not promptly treated with antibiotics, either in association with surgery or not. The incidence of disease has not decreased over the last decades due to the change of risk conditions. Complications of IE may involve cardiac structures when the infection spreads within the heart, or extra cardiac ones when the cause is usually from embolic origin; they may also be due to medical treatment or to the septic condition itself. Read More

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http://link.springer.com/content/pdf/10.1186%2F2110-5820-1-1
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http://www.turner-white.com/pdf/hp_jun03_infective.pdf
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December 2009
18 Reads

Effects of preincubation temperature on the detection of fastidious organisms in delayed-entry samples in the BacT/ALERT 3D blood culture system.

J Microbiol Methods 2009 Nov 4;79(2):194-8. Epub 2009 Sep 4.

National Reference Centre for Streptococci, Institute for Medical Microbiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen, Germany.

This study evaluates the effect of preincubation on delayed-entry samples for fastidious organisms including the HACEK group, Streptococcus species, Neisseria meningitidis, Haemophilus species and Corynebacterium species for the BacT/ALERT 3D System (bioMérieux) using the FA (aerobic) medium. Bottles were inoculated with two different concentrations (0.5 McFarland and a 1:100,000 dilution) of each organism and either loaded into the system immediately or stored at 4 degrees C, room temperature (RT) or 37 degrees C for 24 hours (h) prior to loading. Read More

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http://dx.doi.org/10.1016/j.mimet.2009.08.015DOI Listing
November 2009
17 Reads

Actinobacillus (Aggregatibacter) actinomycetemcomitans (HACEK) identified by PCR/16S rRNA sequence analysis from the heart valve in a patient with blood culture negative endocarditis.

Scand J Infect Dis 2008 ;40(11-12):981-3

Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden.

We report a case of infective endocarditis caused by Actinobacillus actinomycetemcomitans (Aggregatibacter actinomycetemcomitans) from the HACEK group diagnosed by PCR/16S from the heart valve. Multiple blood cultures and cultures from heart valve were negative and cardiac surgery was performed due to therapeutic and cardiac failures. Molecular biological methods are useful in such a patient, to choose an optimal antibiotic treatment post-surgery. Read More

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http://dx.doi.org/10.1080/00365540802325922DOI Listing
February 2009
9 Reads

[Endocarditis due to Aggregatibacter (formerly: Actinobacillus) actinomycetemcomitans, a bacterium that grows in characteristic star-shaped colonies].

Ned Tijdschr Geneeskd 2008 Apr;152(14):827-30

HagaZiekenhuis, Afd. Medische Microbiologie, Den Haag.

A 72-year-old man, having had an artificial valve for almost 20 years now, presented with tiredness that had persisted for several weeks and reported weight loss of 5 kg. In more recent days he experienced fever and cold shivers, and an associated dry cough. Bearing in mind the potential for endocarditis, blood cultures were grown. Read More

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April 2008
3 Reads

Staphylococcus aureus nasal decolonization in joint replacement surgery reduces infection.

Clin Orthop Relat Res 2008 Jun 18;466(6):1349-55. Epub 2008 Mar 18.

Evanston Northwestern Healthcare, Evanston, IL, USA.

Unlabelled: Surgical site infections (SSIs) with Staphylococcus aureus are a recognized adverse event of hip and knee replacements. We evaluated the impact of a program to detect S. aureus nasal carriers before surgery with preoperative decolonization (using mupirocin twice daily for 5 days prior to surgery) of carriers. Read More

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http://dx.doi.org/10.1007/s11999-008-0210-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2384050PMC
June 2008
7 Reads

Infective endocarditis due to Haemophilus aphrophilus: a case report.

J Pediatr (Rio J) 2008 Mar-Apr;84(2):178-80. Epub 2008 Jan 22.

Enfermaria de Pediatria, Hospital de Clínicas, Universidade de Campinas (UNICAMP), Campinas, SP, Brazil.

Objective: To report the case of a child with infective endocarditis caused by Haemophilus aphrophilus.

Description: Boy with 20 days of fever and chills. On admission, he was febrile, pale and with no signs of hemodynamic instability; on cardiac auscultation, a mitral-related holosystolic murmur was observed. Read More

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http://dx.doi.org/10.2223/JPED.1742DOI Listing
September 2008
3 Reads

Non-HACEK gram-negative bacillus endocarditis.

Ann Intern Med 2007 Dec;147(12):829-35

Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27710, USA.

Background: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users.

Objective: To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients.

Design: Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. Read More

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http://annals.org/data/Journals/AIM/20150/0000605-200712180-
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December 2007
17 Reads

Cardiobacterium hominis endocarditis: Two cases and a review of the literature.

Eur J Clin Microbiol Infect Dis 2006 Sep;25(9):587-95

Division of Infectious Diseases, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, 2215 Fuller Road, Ann Arbor, MI 48105, USA.

Cardiobacterium hominis, a member of the HACEK group (Haemophilus parainfluenzae, Haemophilus aphrophilus, and Haemophilus paraphrophilus, Actinobacillus actinomycetemcomitans, C. hominis, Eikenella corrodens, and Kingella species), is a rare cause of endocarditis. There are 61 reported cases of C. Read More

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http://dx.doi.org/10.1007/s10096-006-0189-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276845PMC
September 2006
5 Reads

Epidemiologic, clinical, and microbiologic profile of infective endocarditis in Argentina: a national survey. The Endocarditis Infecciosa en la República Argentina-2 (EIRA-2) Study.

Am Heart J 2006 Feb;151(2):545-52

Area de Investigación y Consejo de Cardiología Clínica Dr Tiburcio Padilla, Argentine Society of Cardiology, Buenos Aires, Argentina.

Background: This study aimed to determine the epidemiologic, clinical, microbiologic characteristics, and inhospital outcome of infective endocarditis (IE) in Argentina and compare the results with those of the 1992 IE national survey.

Methods: A prospective, multicenter study was conducted in 82 hospitals representing 16 of 24 provinces of Argentina. Patients with diagnosis of IE according to the Duke criteria were surveyed during an 18-month period. Read More

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http://dx.doi.org/10.1016/j.ahj.2005.04.008DOI Listing
February 2006
5 Reads
4.463 Impact Factor

Clinical characteristics of invasive Haemophilus aphrophilus infections.

J Microbiol Immunol Infect 2005 Aug;38(4):271-6

Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Haemophilus aphrophilus, an oral fastidious Gram-negative commensal with low pathogenicity, is a member of the HACEK group (H. aphrophilus, H. paraphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella spp. Read More

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August 2005
8 Reads

Infective endocarditis: a review of the best treatment options.

Expert Opin Pharmacother 2004 Sep;5(9):1899-916

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola Hospital, via G. Massarenti 11, I-40138 Bologna, Italy.

Despite significant advances in antimicrobial therapy and an enhanced ability to diagnose and treat complications, infective endocarditis is still associated with substantial morbidity and mortality today, and its incidence has not decreased over the past decades. This apparent paradox may be explained by a progressive change in risk factors, leading to an evolution in its epidemiological and clinical features. In fact, new risk factors for endocarditis have emerged, such as intravenous drug abuse, diffusion of heart surgery procedures and prosthetic valve implantation, atherosclerotic valve disease in elderly patients, and nosocomial disease. Read More

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http://dx.doi.org/10.1517/14656566.5.9.1899 DOI Listing
September 2004
10 Reads

Infective endocarditis in Greece: a changing profile. Epidemiological, microbiological and therapeutic data.

Clin Microbiol Infect 2004 Jun;10(6):556-61

Evangelismos General Hospital, Athens, Greece.

The epidemiology, and clinical and microbiological spectrum, of infective endocarditis (IE) in Greece was analysed in a prospective 4-year study in a tertiary hospital and a heart surgery centre in Athens. In total, 101 cases of IE (71 men, 30 women, aged 54.4 +/- 17. Read More

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http://dx.doi.org/10.1111/j.1469-0691.2004.00884.xDOI Listing
June 2004
14 Reads

Etiology and risk factors of 339 cases of infective endocarditis: report from a 10-year national prospective survey in the Slovak Republic.

J Chemother 2003 Dec;15(6):579-83

Dept. of Pharmacology, Univ. of Trnava School of Public Health at St. Elizabeth's Cancer Institute, Bratislava, Slovak Republic.

The authors studied the etiology, outcome and risk factors of 339 cases of infective endocarditis (IE) in Slovakia over the last 10 years. Aortic valve was infected in 59.9%, mitral in 38. Read More

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http://www.tandfonline.com/doi/full/10.1179/joc.2003.15.6.57
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http://dx.doi.org/10.1179/joc.2003.15.6.579DOI Listing
December 2003
14 Reads

Actinobacillus actinomycetemcomitans endocarditis.

Clin Microbiol Infect 2004 Feb;10(2):98-118

Unité des Rickettsies, Centre National de la Recherche Scientifique, CNRS UMR 6020, WHO Collaborative Center, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.

Among the bacteria of the HACEK group, Actinobacillus actinomycetemcomitans is the organism involved most commonly in infective endocarditis. However, the epidemiological and clinical features specifically associated with this species have not been evaluated adequately. Three patients with infective endocarditis caused by A. Read More

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February 2004
6 Reads

[A 41 year-old male patient with fever of unknown origin and bacteremia with actinobacillus actinomycetemcomitans].

Internist (Berl) 2003 Sep;44(9):1180-5

Klinik III für Innere Medizin, Universität zu Köln, Germany.

A 41-year-old male patient presented with fever of unknown origin which had been present for 5 months. The primary diagnostic procedures did not identify an infectious focus. After a lag phase of 13 days, blood cultures became positive for Actinobacillus actinomycetemcomitans, which belongs to the HACEK group of microorganisms. Read More

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http://link.springer.com/10.1007/s00108-003-1015-4
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http://dx.doi.org/10.1007/s00108-003-1015-4DOI Listing
September 2003
4 Reads