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    4726 results match your criteria Gynecomastia

    1 OF 95

    Clinical Characteristics of Asymmetric Bilateral Gynecomastia: Suggestion of Desirable Surgical Method Based on a Single-Institution Experience.
    Aesthetic Plast Surg 2018 Feb 20. Epub 2018 Feb 20.
    Department of Surgery, Damsoyu Hospital, Central Tower 5-9F, Bongeunsa-ro 213, Gangnam-gu, Seoul, Republic of Korea.
    Background: Asymmetric bilateral gynecomastia (ABGM) is uncommon, and reports on its characteristics are rare. In the present study, we investigated the clinical characteristics and surgical treatment of ABGM.

    Methods: We conducted a retrospective study of 1159 patients with gynecomastia who underwent subcutaneous mastectomy with liposuction at Damsoyu Hospital from January 2014 to February 2016. Read More

    The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.
    J Neurol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
    Objective: Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for the selection of biomarkers for future therapeutic trials.

    Methods: We assessed a panel of 28 laboratory parameters. Read More

    [The forensic medical characteristic of sudden death associated with metabolic syndrome].
    Sud Med Ekspert 2018 ;61(1):60-64
    Bureau of forensic medical expertise, Moscow Health Department, Moscow, Russia, 115516.
    The detection of grade II-III central obesity on a corpse in conjunction with the identification of two additional criteria (such as arterial hypertension and impaired glucose tolerance) provides, if combined with the autopsy data (including the visual reduction of muscular mass, the increased total amount of the adipose tissue, gynecomastia in men together with hypertrophied abdominal adipose tissue accumulation, decreased face and body pilosis), a basis for diagnostics of metabolic syndrome (MS). The objective parameters for this purpose are waist circumference measurements, corpse weight and height, the degree of visceral obesity, narrowing of the renal arteries as a result of their compression by the surrounding adipose tissue, and accumulation of epicardial fat confirmed by the results of the biochemical analysis. The signs of plasmorrhagia combined with fibrinoid degeneration of the vascular walls in the microcirculatory bed make it possible to suspect, with a high degree of probability, the development of hypertensive crisis that may result in a sudden death of the patients presenting with metabolic syndrome. Read More

    Adrenocortical carcinoma characterized by gynecomastia: A case report.
    Clin Pediatr Endocrinol 2018 30;27(1):9-18. Epub 2018 Jan 30.
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
    We present a 4-yr-old boy with adrenocortical carcinoma (ACC), diagnosed due to the appearance of gynecomastia as the presenting symptom. Six months prior to admission, an acute growth spurt along with the development of bilateral breast swelling was observed. He did not present any features of virilization, including enlargement of the testes, increase in testis volume, and penis size. Read More

    Changing practices: The addition of a novel surgical approach to gynecomastia.
    Am J Surg 2018 Jan 29. Epub 2018 Jan 29.
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Surgical Services, John L. McClellan Memorial Veterans Hospital, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. Electronic address:
    Introduction: Gynecomastia can be a significant impediment to quality of life for men who suffer from this affliction. Numerous surgical techniques have been described in the literature ranging from minimally invasive options such as liposuction to incision based reductions. The standard for the general surgeons at our institution has been subcutaneous mastectomy through a circumareolar incision, which often proved inadequate for patients with grade II or III gynecomastia. Read More

    [Gynaecomastia].
    Ugeskr Laeger 2018 Jan;180(4)
    Gynaecomastia (GM) is a benign proliferation of the glandular tissue of the male breast and results from an imbalance between androgen and oestrogen. Pubertal GM is found in 50% and often resolves spontaneously without treatment. GM in adult men can be the first symptom of an underlying disease, and thorough investigation is recommended. Read More

    Recovery from reproductive impact of androgen abuse.
    Curr Opin Endocrinol Diabetes Obes 2018 Jan 31. Epub 2018 Jan 31.
    Department of Endocrinology, University of Ioannina, Ioannina, Greece.
    Purpose Of Review: To summarize recent data on the adverse reproductive consequences of androgen abuse, focusing on the recovery of reproductive function following androgen discontinuation.

    Recent Findings: Evidence is mostly based on case reports and observational studies. Androgen abuse leads to a state of hypogonadotropic hypogonadism associated with impaired spermatogenesis, testicular atrophy, gynecomastia as well as menstrual irregularities, virilization and subfertility. Read More

    Klinefelter syndrome: more than hypogonadism.
    Metabolism 2018 Jan 27. Epub 2018 Jan 27.
    University Hospital of Muenster, Center of Reproductive Medicine and Andrology, Domagkstraße 11, D-48149, Muenster, Germany.
    Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Read More

    Evidence-Based Practice in Liposuction.
    Ann Plast Surg 2018 Jan 24. Epub 2018 Jan 24.
    Background: The goal of this study is to examine the existing peer reviewed literature comparing modern adjunctive techniques in liposuction including laser-assisted liposuction (LAL) and ultrasound-assisted liposuction (UAL) to standard suction-assisted liposuction (SAL). We intend to interpret these findings into a literature-based clinical application to influence practice patterns.

    Methods: A literature review was conducted using a keyword search in PubMed. Read More

    Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys.
    Eur J Cancer 2018 Mar;91:125-135
    Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina. Electronic address:
    Leydig-cell tumours (LCTs) are rare endocrine tumours of the testicular interstitium, with recent increased incidence. Symptoms include precocious puberty in children; and erectile dysfunction, infertility and/or gynaecomastia, in adults. So far, scientific evidence points to aromatase (CYP19) overexpression and excessive oestrogen and insulin-like growth factor (IGF) -1 production as responsible for Leydig-cell tumourigenesis. Read More

    Finasteride topical delivery systems for androgenetic alopecia.
    Curr Drug Deliv 2018 Jan 23. Epub 2018 Jan 23.
    Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad. Pakistan.
    Androgenetic alopecia, generally recognized as male pattern baldness, is a gradually developing medical and physiological change, which is manifested by continuous hair-loss from scalp. Finasteride (4-aza-3-oxosteroid) is a potent anti-baldness compound that selectively and competitively inhibits the 5α-reductase isoenzymes. Prolonged oral use of finasteride leads to the emergence of sexual disorders including decrease in libido, gynecomastia, erectile dysfunction, ejaculation disorder, orgasm disorders and mood disturbances. Read More

    Next Generation Sequencing expression profiling of mitochondrial subunits in men with Klinefelter syndrome.
    Int J Med Sci 2018 1;15(1):31-35. Epub 2018 Jan 1.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    Klinefelter syndrome (KS) is one of the most common sex-chromosome disorders as it affects up to 1 in every 600-1000 newborn males. Men with KS carry one extra X chromosome and they usually present a 47,XXY karyotype, but less frequent variants have also been reported in literature. KS typical symptoms include tall stature, gynecomastia, broad hips, hypogonadism and absent spermatogenesis. Read More

    [Primary breast diffuse large B-cell lymphoma developing subsequent to estramustine therapy for prostate cancer].
    Rinsho Ketsueki 2017;58(12):2411-2413
    Hematology, University of Occupational and Environmental Health.
    An 85-year-old male presented with 1-year history of a right breast mass. Needle biopsy of the mass revealed diffuse proliferation of large lymphoid cells that were positive for CD20, BCL2, BCL6, and MUM1 and negative for CD5, CD10, MYC, and EBER. The patient was diagnosed as having diffuse large B-cell lymphoma, a type of primary breast lymphoma (PBL). Read More

    The unusual suspects: A review of unusual benign and malignant male breast imaging cases.
    Clin Imaging 2017 Dec 28;50:78-85. Epub 2017 Dec 28.
    Columbia University Medical Center Department of Radiology, Herbert Irving Pavilion, 161 Fort Washington Ave, New York, NY 10032, United States. Electronic address:
    Male breast disease is uncommon. Men presenting with breast symptoms may represent unique diagnostic challenges for the radiologist, particularly if imaging findings are not classic for gynecomastia or carcinoma. In this paper we review 10 unusual male breast cases, 5 benign and 5 malignant, including the radiologic findings, differential diagnosis, pathology and management. Read More

    Quantitative CT Assessment of Gynecomastia in the General Population and in Dialysis, Cirrhotic, and Obese Patients.
    Acad Radiol 2018 Jan 8. Epub 2018 Jan 8.
    Department of Radiology, The Chaim Sheba Medical Center, Tel Hashomer, Emek HaEla St 1, Ramat Gan 5265601, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Chaim Levanon St 30, Tel-Aviv 6997801, Israel.
    Rationale And Objectives: Gynecomastia is the benign enlargement of the male breast because of proliferation of the glandular component. To date, there is no radiological definition of gynecomastia and no quantitative evaluation of breast glandular tissues in the general male population. The aims of this study were to supply radiological-based measurements of breast glandular tissue in the general male population, to quantitatively assess the prevalence of gynecomastia according to age by decades, and to evaluate associations between gynecomastia and obesity, cirrhosis, and dialysis. Read More

    Efficiency of Imaging Modalities in Male Breast Disease: Can Ultrasound Give Additional Information for Assessment of Gynecomastia Evolution?
    Eur J Breast Health 2018 Jan 1;14(1):29-34. Epub 2018 Jan 1.
    Department of Radiology, Taksim Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.
    Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia.

    Materials And Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia. Read More

    Managing Male Mammary Maladies.
    Eur J Breast Health 2018 Jan 1;14(1):5-9. Epub 2018 Jan 1.
    Department of Research Oncology, Guy's Hospital, London, England.
    This review examines the symptoms, need for referral and management of the benign breast conditions which afflict males, together with the steps that are necessary to exclude or confirm male breast cancer. The most common complaint is gynaecomastia, either true or pseudo, and the majority of these cases need reassurance without over-investigation. Drugs that induce breast enlargement are described in order that, when possible, a medication switch can be made. Read More

    Discussion on "Gynecomastia Surgery-Impact on Life Quality: A prospective Case-Control Study".
    Ann Plast Surg 2018 Feb;80(2):193-194
    Department of Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy; Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy.

    Ultrasonographic assessment of male breast diseases.
    Breast J 2018 Jan 8. Epub 2018 Jan 8.
    Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
    Although rare and accounting for less than 1% of all breast cancers, the incidence of breast cancer in men has increased by 26% over the past few decades. Very little has been reported on the sonographic appearance of benign and malignant male breast conditions. The aim of this study was to describe the ultrasonographic features of male breast disease and the value of ultrasound in the evaluation of male breast disease. Read More

    A boy with 46,X,+mar presenting gynecomastia and short stature.
    Ann Pediatr Endocrinol Metab 2017 12 31;22(4):266-271. Epub 2017 Dec 31.
    Division of Pediatric Endocrinology, Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
    A 15-year-old boy was referred due to gynecomastia and short stature. He was overweight and showed the knuckle-dimple sign on the left hand, a short fourth toe on the left foot, and male external genitalia with a small phallus. His levels of estradiol and follicle-stimulating hormone were increased, and his testosterone concentration was normal. Read More

    Daily subcutaneous testosterone for management of testosterone deficiency.
    Front Biosci (Elite Ed) 2018 Mar 1;10:334-343. Epub 2018 Mar 1.
    Djehuty Biomed Consulting, 106 Rugged Dr., Red Oak, TX 75154.
    Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects including, infertility, testicular atrophy, erythropoiesis, and gynecomastia. Read More

    Treatment of Paraphilic Disorders in Sexual Offenders or Men With a Risk of Sexual Offending With Luteinizing Hormone-Releasing Hormone Agonists: An Updated Systematic Review.
    J Sex Med 2018 Jan;15(1):77-93
    Institute for Sex Research and Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:
    Background: Different pharmacologic agents are used in the treatment of paraphilic disorders in sexual offenders or men with a risk of sexual offending, with luteinizing hormone-releasing hormone (LHRH) agonists being the agents introduced more recently to treatment regimens.

    Aim: To summarize the relevant literature concerning LHRH agonist treatment of paraphilic disorders in sexual offenders and update the previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890-897).

    Methods: The PubMed and Google Scholar databases were searched for literature published from January 2003 through October 2017 using the following key words: LHRH agonists, GnRH agonists, antiandrogens AND paraphilia, pedophilia, sex offenders. Read More

    [A POEMS syndrome revealed by a blue toe syndrome].
    Rev Med Interne 2018 Feb 26;39(2):127-129. Epub 2017 Dec 26.
    Service de médecine vasculaire, hôpitaux de Brabois, CHRU de Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm UMR-S 1116, université de Lorraine, 54000 Nancy, France.
    Introduction: Arterial and venous thromboses occur in almost one in five patients with POEMS syndrome and usually in macrocirculation.

    Case Report: We report a 67-year-old male with a POEMS syndrome who presented initially with a blue toe syndrome. He complained of Raynaud's syndrome and left foot paresthesia. Read More

    Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do They Reduce Complications? A Different Approach.
    Aesthetic Plast Surg 2017 Dec 20. Epub 2017 Dec 20.
    Plastic, Reconstructive and Cosmetic and Burn Surgery Unit, Hôpital Saint Louis, 1 Avenue Vellefaux, 75010, Paris, France.
    Introduction: We read the manuscript entitled "Closed-suction drains after subcutaneous mastectomy for gynecomastia: do they reduce complications? » published by Chao et al. (Aesthetic Plast Surg, 2017. https://doi. Read More

    Identification of the Underlying Androgen Receptor Defect in the Dallas Reifenstein Family.
    J Endocr Soc 2017 Jul 19;1(7):836-842. Epub 2017 May 19.
    Division of Endocrinology and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390.
    Context: The Dallas Reifenstein family - first described in 1965 - includes 14 known members with partial androgen insensitivity syndrome (PAIS). However, the underlying molecular defect was never identified.

    Objective: To identify the underlying genetic defect for PAIS in the Dallas Reifenstein family. Read More

    Hormonal treatment and quality of life of prostate cancer patients: new evidences.
    Minerva Urol Nefrol 2017 Dec 14. Epub 2017 Dec 14.
    Division of Medical Oncology, Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.
    Androgen deprivation therapy (ADT) is the mainstay of treatment of patients with relapsed or metastatic hormone-sensitive prostatic carcinoma. The dramatic reduction of serum testosterone levels induced by ADT produces multiple side effects as vasomotor flushing, sexual dysfunction, fatigue, impairment of cognitive function, reduced quality of sleep, gynecomastia and anemia, that are able to decrease health-related quality of life (QoL). In addition, hormonal therapy can interfere with bone metabolism and induce metabolic and cardiovascular complications. Read More

    Sellar plasmacytoma presenting with symptoms of anterior pituitary dysfunction.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 Nov 24.
    Endocrinology and Diabetes Department, Garcia de Orta Hospital, Almada, Portugal.
    Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. Read More

    Which patients with gynaecomastia require more detailed investigation?
    Clin Endocrinol (Oxf) 2018 Mar 21;88(3):360-363. Epub 2017 Dec 21.
    Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK.
    Gynaecomastia may be due to medication, chronic liver or kidney disease, hypogonadism (primary or secondary to pituitary disease) or hyperthyroidism. Having excluded these aetiologies, it is imperative to be vigilant for underlying malignancy causing gynaecomastia. These include human chorionic gonadotrophin-secreting testicular and extratesticular tumours and oestrogen-secreting testicular tumours and feminising adrenal tumours. Read More

    Discontinuation of Efavirenz in Paediatric Patients: Why do Children Switch?
    Clin Drug Investig 2017 Nov 27. Epub 2017 Nov 27.
    The Family Clinic, Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London, UK.
    Background: Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) is used globally as first-line antiretroviral therapy (ART) in combination with a dual nucleoside backbone in adults and children from 3 years of age. Up to 40% of adults taking efavirenz report central nervous system (CNS) adverse effects, and the rates of discontinuation of efavirenz-based treatment are higher than other first-line regimens. Data on efavirenz discontinuation are more limited for children and adolescents. Read More

    Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma.
    Clin Nucl Med 2018 Jan;43(1):41-43
    We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. Read More

    A journey through liposuction and liposculture: Review.
    Ann Med Surg (Lond) 2017 Dec 6;24:53-60. Epub 2017 Nov 6.
    Department of Medicine and Surgery, Plastic Surgery Section, University of Parma, Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy.
    Introduction: Nowadays, liposuction is the most frequently performed aesthetic surgery procedure in Western Countries. This technique has had rapid development since the 1970s, when it was experimented for the first time by A. and G. Read More

    The burden of gynecomastia among men on antiretroviral therapy in Zomba, Malawi.
    PLoS One 2017 20;12(11):e0188379. Epub 2017 Nov 20.
    Dignitas International, Zomba, Malawi.
    Background: Many Africans who are on life-saving ART face challenges from a variety of toxicities. After the introduction of a standardized first-line efavirenz-containing ART regimen, reports of gynecomastia appeared in Malawian popular media, however data on the prevalence and risk factors of gynecomastia from Africa are lacking.

    Methods: We conducted a cross-sectional study in males ≥18 years registered on ART at the HIV clinic in Zomba Central Hospital. Read More

    How to manage pseudoangiomatous stromal hyperplasia: our clinical experience
    Turk J Med Sci 2017 11 13;47(5):1410-1415. Epub 2017 Nov 13.
    Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Read More

    Perioral and tongue fasciculations in Kennedy's disease.
    Neurol Sci 2017 Nov 4. Epub 2017 Nov 4.
    Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.
    We report the case of a 54-year-old right-handed man who presented with a 2-year history of progressive upper-limb weakness with mild dysarthria and prominent involuntary perioral abnormal movements that were characterized as fasciculations. Electromyography disclosed motor neuron disease. The diagnosis of Kennedy's disease was established by polymerase chain reaction. Read More

    Endocrinal description of two Chinese Kennedy's disease pedigrees.
    J Clin Neurosci 2018 Jan 6;47:245-248. Epub 2017 Nov 6.
    Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, 200032 Shanghai, China. Electronic address:
    Kennedy's disease (KD), also known as X-linked spinal and bulbar muscular atrophy (SBMA), is caused by the expansion of cytosine-adenine-guanine (CAG) repeats in the first exon of the androgen receptor (AR) gene. KD is a late-onset neural-endocrinal disease that is characterized by the degeneration of motor neurons in the brainstem and spinal cord. In addition, partial androgen insensitivity is an important manifestation of KD. Read More

    Testosterone Therapy: Review of Clinical Applications.
    Am Fam Physician 2017 Oct;96(7):441-449
    Oregon Health and Science University, Portland, OR, USA.
    Testosterone therapy is increasingly common in the United States, and many of these prescriptions are written by primary care physicians. There is conflicting evidence on the benefit of male testosterone therapy for age-related declines in testosterone. Physicians should not measure testosterone levels unless a patient has signs and symptoms of hypogonadism, such as loss of body hair, sexual dysfunction, hot flashes, or gynecomastia. Read More

    [Primary mediastinal choriocarcinoma: A case report and literature review].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Oct;42(10):1222-1227
    Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
    Primary mediastinal choriocarcinoma in male is not a very common disease, with nonspecific clinical manifestations. Gynecomastia and testicular atrophy are present in some cases. The levels of serum human chorionic gonadotropin are often significantly increased. Read More

    Comment to: "Complications and Outcomes After Gynecomastia Surgery: Analysis of 204 Pediatric and 1583 Adult Cases from a National Multi-center Database".
    Aesthetic Plast Surg 2018 Feb 26;42(1):336-337. Epub 2017 Oct 26.
    Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, 6560 Fannin Street, Scurlock Tower, Suite 2200, Houston, TX, 77030, USA.
    Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer. Read More

    A Submammarian Approach for Cosmetically Improved Implantation of Deep Brain Stimulation Generators.
    World Neurosurg 2018 Jan 20;109:e699-e706. Epub 2017 Oct 20.
    Department of Stereotactical Neurosurgery, Barbara-Hospital, Hamm, Germany.
    Background: Deep brain stimulation (DBS) indications include movement disorders, psychiatric affections, or epilepsy in which patients risk social isolation heightened by abnormal motions or behavioral patterns. Further stigmatization after DBS surgery from head shaving, visible scarring, or disfigurement from bulky lead insertion points should be avoided.

    Objective: We present a cosmetically optimized, adapted submammarian approach for DBS neurostimulator implantation that leaves the décolletage untouched. Read More

    Breast diseases in children: the spectrum of radiologic findings in a cohort study.
    Diagn Interv Radiol 2017 Nov-Dec;23(6):407-413
    Department of Radiology, Akdeniz University School of Medicine, Antalya, Turkey.
    Purpose: We aimed to investigate the spectrum of radiologic findings and referral reasons for breast diseases in children considering age-appropriate presentation.

    Methods: Our retrospective cohort study included 348 consecutive pediatric patients aged <19 years (median, 13 years) referred to radiology with a clinical presentation between 2005 and 2016. Radiologic findings were reviewed in four age ranges (0-2 years, 2-8 years, 8-15 years, >15 years). Read More

    Low zinc levels may contribute to gynecomastia in puberty.
    J Trace Elem Med Biol 2017 Dec 2;44:274-278. Epub 2017 Sep 2.
    Department of Toxicology, Hacettepe University, Faculty of Pharmacy, Ankara, Turkey; Adolescent Unit, İhsan Doğramacı Children's Hospital, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sıhhiye Ankara, Turkey. Electronic address:
    This study aimed to determine whether there were any differences in trace element levels between adolescent boys with gynecomastia and control boys and to determine the correlations between the levels of trace elements and body mass index (BMI) and sex hormones. The pubertal gynecomastia group comprised of 41 patients (mean age=13.2 ±0. Read More

    A Comparison of Adverse Drug Reaction Profiles in Patients on Antiretroviral and Antitubercular Treatment in Zimbabwe.
    Clin Drug Investig 2018 Jan;38(1):9-17
    Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, P O Box A178, Avondale, Harare, Zimbabwe.
    Introduction: Few studies describe the adverse drug event profiles in patients simultaneously receiving antiretroviral and anti-tubercular medicines in resource-limited countries.

    Objectives: To describe and compare the adverse drug reaction profiles in patients on highly active antiretroviral therapy only (HAART), HAART and isoniazid preventive therapy (HHART), and HAART and antitubercular treatment (ATTHAART).

    Methods: We analysed individual case safety reports (ICSRs) for patients on antiretroviral therapy and antitubercular treatment submitted to the national pharmacovigilance centre during the targeted spontaneous reporting (TSR) programme from 1 September 2012 through 31 August 2016. Read More

    Multiparameter Investigation of a 46,XX/46,XY Tetragametic Chimeric Phenotypical Male Patient with Bilateral Scrotal Ovotestes and Ovulatory Activity.
    Sex Dev 2017 Sep 20. Epub 2017 Sep 20.
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
    We report on an adult male initially presenting with gynecomastia and a painless scrotal mass without additional genital anomalies. Hyperpigmentation of the skin following the Blaschko's lines was identified. He underwent gonadectomy because of suspected cancer. Read More

    Chromosome 15 structural abnormalities: effect ongene expression and function.
    Endocr Connect 2017 Oct;6(7):528-539
    Department of Clinical and Experimental MedicineUniversity of Catania, Catania, Italy
    Insulin-like growth factor 1 receptor (), mapping on the 15q26.3 chromosome, is required for normal embryonic and postnatal growth. The aim of the present study was to evaluate thegene expression and function in three unrelated patients with chromosome 15 structural abnormalities. Read More

    A case of Klinefelter syndrome with hypersexual desire.
    Endocrinol Diabetes Metab Case Rep 2017 29;2017. Epub 2017 Aug 29.
    Department of Endocrinology, Canberra Hospital, Canberra, ACTAustralia.
    Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders. Read More

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