4,830 results match your criteria Gynecomastia
Semin Diagn Pathol 2018 Nov 17. Epub 2018 Nov 17.
Department of Pathology, Emory University Hospital, Atlanta, GA 30322, United States. Electronic address:
Developmental abnormalities and malformations of the breast are rare and encompass a variety of genetic, syndromic, acquired and sporadic conditions. Abnormalities in development may include irregularities in the nipple areolar complex and/or the underlying glandular tissue, resulting in under or overdevelopment of breasts. Age of presentation and clinical severity is dependent on the underlying biologic cause. Read More
Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.
Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. Read More
Aesthetic Plast Surg 2018 Nov 27. Epub 2018 Nov 27.
Department of Plastic, Reconstructive and Aesthetic Surgery "Campus Bio-Medico", University of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy.
Kidney Int 2018 Nov 22. Epub 2018 Nov 22.
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
The safety and efficacy of spironolactone is uncertain in end-stage renal disease. We randomized 129 maintenance hemodialysis patients to placebo (n=51) or spironolactone 12.5 mg (n=27), 25 mg (n=26), or 50 mg (n=25) daily for 36 weeks in a double-blind, placebo-controlled, multiple dosage trial to assess safety, tolerability and feasibility and to explore cardiovascular efficacy. Read More
J Intern Med 2018 Nov 20. Epub 2018 Nov 20.
Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
Background: The lifetime prevalence of androgenic anabolic steroid abuse is estimated to be around 6% for men, but there is limited knowledge about the side effects of these drugs.
Objective: To investigate mortality and morbidity amongst users of androgenic anabolic steroids (AAS).
Methods: In this retrospective matched cohort study, 545 male subjects tested positive for AAS in Danish fitness centres during the period 3 January 2006 to 1 March 2018. Read More
J Pediatr Endocrinol Metab 2018 Dec;31(12):1381-1386
Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Background Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal polyposis, mucocutaneous pigmentation and cancer predisposition. Patients with PJS can develop large calcifying Sertoli cell tumors (LCSTs). Case presentation A patient presented at 3 years of age with delayed development, hypermobility and later also with tall stature and advanced bone age. Read More
Cesk Patol 2018 ;54(3):143-146
Diagnosing accessory breast tissue in a male patient is difficult when the condition is unilateral, and there is no areola or nipple. Pseudoangiomatous hyperplasia of the mammary stroma is an uncommon benign mesenchymal proliferation that may mimic low-grade angiosarcoma. We report herein an example of tumoriform pseudoangiomatous hyperplasia of the stroma arising in the accessory breast tissue of a 38-year-old man. Read More
Curr Clin Pharmacol 2018 Nov 15. Epub 2018 Nov 15.
Department of Clinical Pharmacology, SRM MCH &RC, Kattankulathur, Chennai, Tamil Nadu. India.
Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon. Read More
Int J Adolesc Med Health 2018 Nov 6. Epub 2018 Nov 6.
Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
Background The aim of the study was to evaluate the dynamic thiol/disulfide homeostasis (TDH) with a new method in patients with pubertal gynecomastia and also to investigate the relationship between sex hormones. Methods Thiol/disulfide homeostasis, involving native thiol (SH), disulfide (SS) and total thiol (SS + SH), was evaluated between 20 adolescent boys with gynecomastia in mid-puberty and 50 healthy adolescents, who were matched for age, body mass index (BMI) and pubertal stage. The correlations of total serum testosterone (TT) and estradiol (E2) levels with the oxidative parameters were also determined. Read More
J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.
Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.
Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More
J Am Coll Radiol 2018 Nov;15(11S):S313-S320
Panel Chair, Emory University Hospital, Atlanta, Georgia.
Although the majority of male breast problems are benign with gynecomastia as the most common etiology, men with breast symptoms and their referring providers are typically concerned about whether or not it is due to breast cancer. If the differentiation between benign disease and breast cancer cannot be made on the basis of clinical findings, or if the clinical presentation is suspicious, imaging is indicated. The panel recommends the following approach to breast imaging in symptomatic men. Read More
BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.
Endocrinology, Hospital de Egas Moniz, Lisbon, Portugal.
A 42-year-old African man presented with hypogonadic phenotypical features, including gynoid body distribution, gynaecomastia, absent facial and truncal hair and micropenis. He denied ever experiencing development of male secondary sex characteristics. Endocrine testing revealed hypergonadotropic hypogonadism and undetectable AMH. Read More
EBioMedicine 2018 Oct 11;36:401-409. Epub 2018 Oct 11.
University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom. Electronic address:
Background: PAIS exhibits a complex spectrum of phenotypes and pubertal outcomes. The paucity of reliable prognostic indicators can confound management decisions including sex-of-rearing. We assessed whether external masculinisation score (EMS) at birth or functional assays correlates with pubertal outcome in PAIS patients and whether the EMS is helpful in sex assignment. Read More
Reprod Toxicol 2018 Oct 11;82:63-71. Epub 2018 Oct 11.
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, United States. Electronic address:
The CD-1 mouse mammary gland is sexually dimorphic, with males lacking nipples. Recent studies have revealed that the underlying epithelium in the male mammary gland is sensitive to estrogenic environmental chemicals. In ongoing investigations, we observed asymmetric morphology in the left and right male mouse mammary glands. Read More
Mod Pathol 2018 Oct 11. Epub 2018 Oct 11.
Department of Pathology, Harvard Medical School, Boston, MA, USA.
Breast reduction surgery or mastectomy following administration of androgen therapy is part of the female-to-male gender reassignment process. Details regarding the histopathologic findings in breast tissue from patients undergoing female-to-male gender reassignment surgery are limited. We reviewed hematoxylin and eosin-stained sections of breast tissue from 148 patients who underwent breast reduction surgery or mastectomy as part of the female-to-male gender reassignment process at our institution between January 2014 and May 2017. Read More
Ann Dermatol Venereol 2018 Oct 6. Epub 2018 Oct 6.
Service de dermatologie et IST, CHU Sylvanus Olympio, BP 30785, Lomé, Togo.
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs often used in the first-line treatment regimen of HIV1 infection worldwide. We report a case of successive gynecomastia and Stevens-Johnson syndrome (SJS) respectively induced by efavirenz and nevirapine in a single patient.
Case Report: A 16-year-old boy, HIV1-infected since birth, was started on antiretroviral treatment (ART) in August 2015 and was taking a regimen comprising abacavir, lamivudine and efavirenz. Read More
G Ital Dermatol Venereol 2018 Oct 3. Epub 2018 Oct 3.
Dermatology Department, University of Pisa, Pisa, Italy.
J Adolesc Health 2018 Dec 29;63(6):759-765. Epub 2018 Sep 29.
Adolescent Breast Clinic, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Plastic and Oral Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:
Purpose: Despite the psychosocial deficits associated with gynecomastia, surgical treatment of adolescent gynecomastia remains controversial. This longitudinal cohort study measures changes in health-related quality of life following surgical treatment of gynecomastia in adolescents.
Methods: The following surveys were administered to adolescents with gynecomastia and male controls, aged 12-21 years: Short-Form 36v2 (SF-36), Rosenberg Self-Esteem Scale (RSES), and Eating-Attitudes Test-26. Read More
F1000Res 2018 30;7:677. Epub 2018 May 30.
Marie-Curie Sklodowska University, Lublin, Poland.
Adverse drug reactions (ADRs) are a major cause of hospital admissions, prolonged hospital stays, morbidity, and drug-related mortality. In this study, we sought to identify the most frequently reported medications and associated side effects in adolescent-aged patients in an effort to prioritize clinical pharmacology consultation efforts for hospitals seeking to improve patient safety. Quarterly reported data were obtained from the United States Food and Drug Administration Adverse Events Reporting System (FAERS) from the third quarter of 2014 and ending in the third quarter of 2017. Read More
Aesthetic Plast Surg 2018 Dec 26;42(6):1506-1518. Epub 2018 Sep 26.
Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, Rome, Italy.
Introduction: The objectives of this study are: (1) comparison of long-term outcomes after correction of severe gynecomastia using different techniques; (2) apply the Italian version of the BODY-Q; (3) present the role of intercostal perforator flap (ICAP) after massive weight loss for correction of severe gynecomastia.
Materials And Methods: Between January 2008 and March 2016, we performed surgical correction of bilateral severe gynecomastia in 80 men (160 breasts) following massive weight loss. Patients answered the Italian version of BODY-Q postoperative module. Read More
Plast Reconstr Surg 2018 Oct;142(4):908-909
Pittsburgh, Pa. From the Department of Plastic Surgery, University of Pittsburgh Medical Center.
Plast Reconstr Surg 2018 Oct;142(4):904-907
Austin, Texas From private practice.
Gynecomastia awareness and treatment have increased significantly. Treatment of gynecomastia is now one of the most popular procedures requested by men. There are many gynecomastia classification systems that have been described. Read More
J Mol Recognit 2018 Sep 24:e2764. Epub 2018 Sep 24.
Department of Chemistry and Research Institute of Natural Sciences, Hanyang University, Seoul, Republic of Korea.
Endocrine-disrupting chemicals are a major public health problem throughout the world. In the human body, these compounds functionalize the same as sexual hormones, inducing precocious puberty, gynecomastia, etc. To help prevent this occurrence, a simple detection system is needed. Read More
Oncology (Williston Park) 2018 09;32(9):470-4, CV3
The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). This therapy is associated with a multitude of side effects that can impact quality of life. These include vasomotor complications (in particular, hot flushes), sexual dysfunction and gynecomastia, osteoporosis, metabolic syndrome, and depression. Read More
Aesthetic Plast Surg 2018 Dec 17;42(6):1591-1599. Epub 2018 Sep 17.
A-Plast Estetik, Akasya AVM, A1 Kule, D:117Acıbadem, Istanbul, Turkey.
Introduction: Combined and/or multistage operations often are needed in postbariatric surgery.
Aim: With this retrospective study of a series of 55 cases, we aim to determine the effectiveness and safety of one-stage combined postbariatric surgery.
Materials And Methods: A total of 248 postbariatric procedures were performed in one session (except one-staged gynecomastia case) in 55 patients. Read More
Arch Argent Pediatr 2018 Oct;116(5):e655-e658
Unidad de Endocrinología Pediátrica, Hospital Universitario Reina Sofía (Córdoba), España.
Gynecomastia consists of breast enlargement due to a hormonal imbalance between estrogens and androgens. Unilateral and important breast growth requires ruling underlying pathologic disorders out. Mechanical cause is uncommon, causing enlargement by repeated stimulation. Read More
Plast Reconstr Surg 2018 Dec;142(6):1600-1608
Hamilton, Toronto, and Mississauga, Ontario, Canada; Odense and Esbjerg, Denmark; Eindhoven and Amsterdam, The Netherlands; Houston, Texas; New York, N.Y.; and Jyväskylä, Finland For the authors' affiliations, see the Appendix at the end of the article.
Background: Plastic surgery to improve chest appearance is becoming increasingly popular. The BODY-Q is a patient-reported outcome instrument designed for weight loss and/or body contouring. In this article, the authors describe the development of a new module for masculinizing chest contouring surgery. Read More
Heart Vessels 2018 Sep 10. Epub 2018 Sep 10.
Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Differences in the clinical impacts of the aldosterone receptor antagonists spironolactone and eplerenone in patients with heart failure (HF) are unclear. Among 838 prospectively enrolled patients hospitalized for HF, 90 treated with eplerenone were compared with 90 treated with spironolactone. The primary endpoint was a composite of cardiovascular death and hospitalization. Read More
Adv Radiat Oncol 2018 Jul-Sep;3(3):240-244. Epub 2018 Feb 26.
Department of Radiation Oncology, University of Muenster, Muenster, Germany.
Purpose: Radiation therapy (RT) is a common treatment for benign diseases in Germany. Because the treatment concepts are inconsistent, we conducted this pattern-of-care study on behalf of the German Cooperative Group on Benign Diseases to evaluate treatment standards in Germany.
Methods And Materials: Questionnaires were mailed to all radiation therapy facilities in Germany. Read More
J Plast Surg Hand Surg 2018 Sep 4:1-4. Epub 2018 Sep 4.
a Department of Plastic Surgery , Odense University Hospital , Odense , Denmark.
The aim of this study was to translate and linguistically validate the patient-reported outcome (PRO) instrument body-q chest module, designed to measure outcomes following chest contouring surgery. The BODY-Q Chest Module includes two scales that measure appearance of chest and nipples. The translation and validation were performed according to the guidelines from the world health organization (who) and the international society for pharmacoeconomics and outcomes research (ISPOR). Read More
Gland Surg 2018 Aug;7(Suppl 1):S70-S76
Department of Plastic Surgery, Odense University Hospital, Odense C, Denmark.
Gynecomastia affects up to two-thirds of the male population. For many patients the psychological impact of the disease is substantial. Surgical treatment is indicated when medical treatments fail. Read More
Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6.
Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.
Pediatric breast disease is uncommon, and primary breast carcinoma in children is extremely rare. Therefore, the approach used to address breast lesions in pediatric patients differs from that in adults in many ways. Knowledge of the normal imaging features at various stages of development and the characteristics of breast disease in the pediatric population can help the radiologist to make confident diagnoses and manage patients appropriately. Read More
BMJ Case Rep 2018 Sep 1;2018. Epub 2018 Sep 1.
Department of Internal Medicine, Charleston Area Medical Center, Charleston, South Carolina, USA.
Mitotane is a cytostatic antineoplastic agent that is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. The commonly reported side effects associated with mitotane are anorexia, nausea, vomiting, diarrhoea, decreased memory, rash, gynaecomastia, arthralgias and leucopenia. We present a case of a 68-year-old female who developed gradual dyspnoea concurrent with the use of mitotane for the treatment of adrenocortical carcinoma. Read More
Ann Plast Surg 2018 Aug 29. Epub 2018 Aug 29.
Plastic and Reconstructive Microsurgery CTO Careggi University Hospita Florence, Italy
Endocrinol Diabetes Metab Case Rep 2018 23;2018. Epub 2018 Aug 23.
Starship Children's Health, Auckland District Health Board, Auckland, New Zealand.
Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual disease, adjuvant therapy is recommended with mitotane, an adrenolytic and cytotoxic drug. In addition to the anticipated side effect of adrenal insufficiency, mitotane is known to cause gynecomastia and hypothyroidism in adults. Read More
Clin Case Rep 2018 Aug 14;6(8):1481-1484. Epub 2018 Jun 14.
Pediatric Endocrinology Unit Department of Maternal and Children's Health Fondazione IRCCS Policlinico S. Matteo and University of Pavia Pavia Italy.
In patients with autoimmune disease, gynecomastia should not be considered as 1 of the first signs of hyperthyroidism, rather it is a breast pathology that can be present even when euthyroidism restoration is achieved. It is unknown whether the autoimmune nature of thyroid disorders or simply the hyperthyroidism effects breast changes. Read More
Hellenic J Cardiol 2018 Aug 24. Epub 2018 Aug 24.
Microbiological Laboratory General Hospital of Katerini, 6o Km Katerinis-Arona, Katerini, 60100, Greece. Electronic address:
Curr Probl Diagn Radiol 2018 Jul 29. Epub 2018 Jul 29.
Boston University School of Medicine, Boston Medical Center, Section of Breast Imaging, Department of Radiology, Boston, MA.
The male breast is susceptible to a variety of benign and malignant processes, many of which clinically present as a palpable finding, focal pain, or breast enlargement. Gynecomastia is the most common abnormality in the male breast and must be distinguished from malignancy. Imaging of the symptomatic male breast begins with a diagnostic mammogram in a patient ≥25 years and targeted ultrasound in a patient <25 years. Read More
Clin Psychopharmacol Neurosci 2018 Aug;16(3):343-345
Department of Child and Adolescent Psychiatry, Aksaray State Hospital, Aksaray, Turkey.
Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Read More
Exp Ther Med 2018 Aug 25;16(2):797-801. Epub 2018 May 25.
Department of Thyroid and Breast Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Gynecomastia is a common benign condition of the male breast, frequently observed in newborns, adolescents and the elderly. Surgical excision remains one of the most effective methods for the management of patients with gynecomastia, particularly those with fibrosis or a course of >1 year. The present study describes two cases of patients with gynecomastia and presents a novel method of treatment, combining endoscopic surgery and liposuction using a TriPort, which may effectively remove breast tissue and shorten hospitalization time compared with a direct excision method. Read More
Case Rep Urol 2018 19;2018:7202560. Epub 2018 Jul 19.
Department of Urology and Pediatric Urology, Saarland University, Homburg/Saar, Germany.
Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Read More
Drug Des Devel Ther 2018 23;12:2259-2265. Epub 2018 Jul 23.
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia,
Introduction: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness. Read More
Plast Reconstr Surg 2018 Nov;142(5):1125-1132
Amsterdam, The Netherlands; and Hamilton, Ontario, Canada From the Departments of Plastic, Reconstructive and Hand Surgery and Medical Psychology and Sexology, VU University Medical Center; and the Departments of Pediatrics and Clinical Epidemiology & Biostatistics, McMaster University.
Background: The effectiveness of gender-confirming surgery is best evaluated on the basis of patient-reported outcomes. This is the first explorative study using the BODY-Q chest module, administered in trans men before and after mastectomy.
Methods: Between October of 2016 and May of 2017, trans men were recruited to participate in a cross-sectional study. Read More
Aesthetic Plast Surg 2018 Dec 9;42(6):1716-1717. Epub 2018 Aug 9.
Plastic and Reconstructive Microsurgery, Careggi University Hospital, Viale Giacomo Matteotti 42, 50132, Florence, Italy.
Endocrinol Diabetes Metab Case Rep 2018 26;2018. Epub 2018 Jul 26.
Department of Diabetes and Endocrinology, Flinders Medical Centre, Bedford Park, South Australia, Australia.
A 40-year-old man with achondroplasia presented with symptoms of hypogonadism, low libido and gynaecomastia. He was found to have hypergonadotropic hypogonadism, and karyotype and fluorescent hybridisation analysis showed -positive 46, XX disorder of sex development (DSD). He was tested to have the common activating mutation of the gene implicated in achondroplasia, indicating that he had the two rare conditions independently, with an extremely low incidence of 1 in 400 million. Read More
Breast J 2018 Nov 5;24(6):1043-1045. Epub 2018 Aug 5.
Buckinghamshire NHS Healthcare Trust, Buckinghamshire, UK.
Background: Idiopathic gynecomastia is a benign breast disorder characterized by overdevelopment of male breast tissue. It can cause discomfort and concern, resulting in patients seeking diagnosis and treatment. We aimed to evaluate the efficacy of tamoxifen therapy in resolving this condition. Read More
J Pediatr Endocrinol Metab 2018 Oct;31(10):1149-1154
Paediatric Endocrinology Unit, Hospital Dona Estefânia - Centro Hospitalar Lisboa Central, Lisboa, Portugal.
Background Gynaecomastia, although rarely related to testicular tumours, in boys with Peutz-Jeghers syndrome (PJS) usually occurs due to large-cell calcifying Sertoli cell tumour (LCCSCT). Case presentation A 4-year-old boy, with a genetic diagnosis of PJS, presented gynaecomastia since the age of 2, associated with increased height velocity (HV). He exhibited bilateral breast enlargement (Tanner-B4) and a testicular volume of 4 mL. Read More
Cureus 2018 May 21;10(5):e2661. Epub 2018 May 21.
Instituto De Ensino E Pesquisa, Hospital Sirio Libanes.
Oxytocin has been administered to patients with autism spectrum disorder (ASD) in order to improve social skills, communication, and manage repetitive behaviors in the context of research trials. The majority of the studies focus on acute administration; thus, the effectiveness and potential side effects of chronic administration remain unknown. The main goal of this case report is to highlight the importance of the safety parameters for the chronic use of intranasal oxytocin administration. Read More