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Breast J 2019 Feb 7. Epub 2019 Feb 7.

Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Lodz, Poland.

Gan To Kagaku Ryoho 2018 Dec;45(13):1857-1859

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

History of male breast cancer and pancreatic cancer are important for diagnosis of hereditary breast and ovarian cancer syndrome(HBOC), while advanced pancreatic cancer is reported to have metastasis to mammary gland tissue. A 67-year-old man visited a local hospital because fever and right hypochondrial pain. Computed tomography scan revealed pancreatic cancer with multiple liver metastasis and peritoneal metastasis. Read More

Int J Clin Pharm 2019 Jan 25. Epub 2019 Jan 25.

Department of Pharmacy, Xiamen Maternity and Child Health Care Hospital, No. 10 Zhenhai Road, Xiamen, 361001, Fujian Province, China.

Background Tamoxifen is an estrogen receptor modulator used for the treatment of breast cancer; however, currently, it is used in many off-label indications. Objective To investigate the prevalence of tamoxifen off-label prescribing and explore available scientific evidence that supports those uses in outpatients. Setting Xiamen maternity and child health care hospital in Xiamen city of China. Read More

Breast Cancer Res Treat 2019 Jan 21. Epub 2019 Jan 21.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

Purpose: Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men.

Methods: Review of 932 males with breast pathology was performed to identify cases of ADH. Read More

BMC Med Genet 2019 Jan 7;20(1). Epub 2019 Jan 7.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Klinefelter syndrome (KS) is characterized by the presence of at least one supernumerary X chromosome. KS typical symptoms include tall stature, gynecomastia, hypogonadism and azoospermia. KS patients show a higher risk of developing metabolic and cardiovascular diseases, inflammatory and autoimmune disorders, osteoporosis and cancer. Read More

Funct Integr Genomics 2019 Jan 6. Epub 2019 Jan 6.

Department of Neurology, Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.

Kennedy's disease, resulted from the expansion of a CAG repeat in exon 1 of androgen receptor (AR) gene, is a motor neuron degenerative disease in the brainstem and spinal cord with the slow development of facial, bulbar, and limb muscle degeneration. To investigate the clinical manifestations and gene mutations in Han Chinese patients with Kennedy's disease. The clinical manifestations of 5 male Han Chinese patients including 2 probands and their relatives from 2 families and 1 sporadic case were retrospectively studied. Read More

Asian J Androl 2018 Dec 25. Epub 2018 Dec 25.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Gonadotropin therapy is commonly used to induce virilization and spermatogenesis in male isolated hypogonadotropic hypogonadism (IHH) patients. In clinical practice, 5.6%-15. Read More

Respir Med Case Rep 2019 4;26:146-149. Epub 2018 Dec 4.

Thoracic Surgery Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.

Gynecomastia with mastodynia and galactorrhea as a paraneoplastic syndrome due to lung cancer with complete response after surgical excision is rare. A 62-year-old Caucasian male presented with mastodynia, galactorrhea and right breast enlargement. Chest x-ray revealed a left upper lobe tumor. Read More

Endocrinol Diabetes Metab Case Rep 2018 Dec 28;2018. Epub 2018 Dec 28.

Division of Endocrinology, Children's National Health System, Washington, District of Columbia, USA.

Pubertal gynecomastia is common, can be seen in 65% of the adolescent boys and is considered physiological. It is thought to be due to transient imbalance between the ratio of testosterone and estradiol in the early stages of puberty. It resolves in 1-2 years and requires no treatment. Read More

Plast Reconstr Surg 2018 Dec 31. Epub 2018 Dec 31.

Plastic, Reconstructive and Cosmetic and Burn Surgery unit, hôpital Saint Louis, Paris, France.

Plast Reconstr Surg 2018 Dec 31. Epub 2018 Dec 31.

Division of Plastic Surgery, Department of Surgery, University of British Columbia.

Malays J Pathol 2018 Dec;40(3):343-348

University of Niš Faculty of Medicine, Scientific Research Centre for Biomedicine, Serbia, Zoran Đinđic Boulevard 81, 18000 Niš, Serbia.

Introduction: There are less than 100 cases of Large-cell calcifying Sertoli cell tumour (LCCSCT) reported in English literature. Most of them are benign, bilateral and affect paediatric population. Malignant cases occur in older patients. Read More

Maedica (Buchar) 2018 Sep;13(3):196-201

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Background: Breast carcinoma is the most important cause of death in women's oncologic pathology worldwide. Due to its high frequency, important advances in diagnostic and management of this entity were made. Because of its rarity (only 0. Read More

Sex Med Rev 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, University of Virginia, Charlottesville, VA, USA.

Introduction: Clomiphene citrate (CC) is a selective estrogen receptor modulator that has been used for the treatment of hypogonadism in men since the 1970s. It acts centrally to increase secretion of luteinizing hormone and follicle-stimulating hormone, thereby increasing testosterone production and serum levels. Unlike testosterone replacement therapy, CC does not suppress the hypothalamic-pituitary-gonadal axis, preserving intratesticular testosterone production and spermatogenesis. Read More

J Pediatr Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background Aromatase excess syndrome (AEXS) is a rare autosomal dominant disorder caused by CYP19A1 overexpression. Clinical manifestations of AEXS include pre- or peri-pubertal gynecomastia, advanced bone age and compromised adult height. Case presentation Here we report an 8-year-old boy diagnosed with AEXS by chromosomal array that revealed a 1. Read More

Kaohsiung J Med Sci 2018 12 4;34(12):705-706. Epub 2018 Jul 4.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Excellence Center in Diabetes, Hormones and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Electronic address:

Semin Diagn Pathol 2019 Jan 17;36(1):11-15. Epub 2018 Nov 17.

Department of Pathology, Emory University Hospital, Atlanta, GA 30322, United States. Electronic address:

Developmental abnormalities and malformations of the breast are rare and encompass a variety of genetic, syndromic, acquired and sporadic conditions. Abnormalities in development may include irregularities in the nipple areolar complex and/or the underlying glandular tissue, resulting in under or overdevelopment of breasts. Age of presentation and clinical severity is dependent on the underlying biologic cause. Read More

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. Read More

Aesthetic Plast Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Plastic, Reconstructive and Aesthetic Surgery "Campus Bio-Medico", University of Rome, Via Alvaro del Portillo, 200, 00128, Rome, Italy.

Kidney Int 2018 Nov 22. Epub 2018 Nov 22.

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

The safety and efficacy of spironolactone is uncertain in end-stage renal disease. We randomized 129 maintenance hemodialysis patients to placebo (n=51) or spironolactone 12.5 mg (n=27), 25 mg (n=26), or 50 mg (n=25) daily for 36 weeks in a double-blind, placebo-controlled, multiple dosage trial to assess safety, tolerability and feasibility and to explore cardiovascular efficacy. Read More

J Intern Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: The lifetime prevalence of androgenic anabolic steroid abuse is estimated to be around 6% for men, but there is limited knowledge about the side effects of these drugs.

Objective: To investigate mortality and morbidity amongst users of androgenic anabolic steroids (AAS).

Methods: In this retrospective matched cohort study, 545 male subjects tested positive for AAS in Danish fitness centres during the period 3 January 2006 to 1 March 2018. Read More

J Pediatr Endocrinol Metab 2018 Dec;31(12):1381-1386

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Background Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal polyposis, mucocutaneous pigmentation and cancer predisposition. Patients with PJS can develop large calcifying Sertoli cell tumors (LCSTs). Case presentation A patient presented at 3 years of age with delayed development, hypermobility and later also with tall stature and advanced bone age. Read More

Cesk Patol 2018 ;54(3):143-146

Diagnosing accessory breast tissue in a male patient is difficult when the condition is unilateral, and there is no areola or nipple. Pseudoangiomatous hyperplasia of the mammary stroma is an uncommon benign mesenchymal proliferation that may mimic low-grade angiosarcoma. We report herein an example of tumoriform pseudoangiomatous hyperplasia of the stroma arising in the accessory breast tissue of a 38-year-old man. Read More

Curr Clin Pharmacol 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Pharmacology, SRM MCH &RC, Kattankulathur, Chennai, Tamil Nadu. India.

Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phenomenon. Read More

Int J Adolesc Med Health 2018 Nov 6. Epub 2018 Nov 6.

Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.

Background The aim of the study was to evaluate the dynamic thiol/disulfide homeostasis (TDH) with a new method in patients with pubertal gynecomastia and also to investigate the relationship between sex hormones. Methods Thiol/disulfide homeostasis, involving native thiol (SH), disulfide (SS) and total thiol (SS + SH), was evaluated between 20 adolescent boys with gynecomastia in mid-puberty and 50 healthy adolescents, who were matched for age, body mass index (BMI) and pubertal stage. The correlations of total serum testosterone (TT) and estradiol (E2) levels with the oxidative parameters were also determined. Read More

J Clin Res Pediatr Endocrinol 2018 Nov 5. Epub 2018 Nov 5.

Objective: We aimed to study the characteristics on admission, diagnosis, treatment, and follow-up of hyperprolactinemic cases in a large multicenter study.

Methods: We reviewed 233 hyperprolactinemic patients under 18 years of age who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia, and idiopathic hyperprolactinemia. Read More

J Am Coll Radiol 2018 Nov;15(11S):S313-S320

Panel Chair, Emory University Hospital, Atlanta, Georgia.

Although the majority of male breast problems are benign with gynecomastia as the most common etiology, men with breast symptoms and their referring providers are typically concerned about whether or not it is due to breast cancer. If the differentiation between benign disease and breast cancer cannot be made on the basis of clinical findings, or if the clinical presentation is suspicious, imaging is indicated. The panel recommends the following approach to breast imaging in symptomatic men. Read More

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Endocrinology, Hospital de Egas Moniz, Lisbon, Portugal.

A 42-year-old African man presented with hypogonadic phenotypical features, including gynoid body distribution, gynaecomastia, absent facial and truncal hair and micropenis. He denied ever experiencing development of male secondary sex characteristics. Endocrine testing revealed hypergonadotropic hypogonadism and undetectable AMH. Read More

EBioMedicine 2018 Oct 11;36:401-409. Epub 2018 Oct 11.

University of Cambridge, Department of Paediatrics, Cambridge, United Kingdom. Electronic address:

Background: PAIS exhibits a complex spectrum of phenotypes and pubertal outcomes. The paucity of reliable prognostic indicators can confound management decisions including sex-of-rearing. We assessed whether external masculinisation score (EMS) at birth or functional assays correlates with pubertal outcome in PAIS patients and whether the EMS is helpful in sex assignment. Read More

Reprod Toxicol 2018 Dec 11;82:63-71. Epub 2018 Oct 11.

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, United States. Electronic address:

The CD-1 mouse mammary gland is sexually dimorphic, with males lacking nipples. Recent studies have revealed that the underlying epithelium in the male mammary gland is sensitive to estrogenic environmental chemicals. In ongoing investigations, we observed asymmetric morphology in the left and right male mouse mammary glands. Read More

Mod Pathol 2018 Oct 11. Epub 2018 Oct 11.

Department of Pathology, Harvard Medical School, Boston, MA, USA.

Breast reduction surgery or mastectomy following administration of androgen therapy is part of the female-to-male gender reassignment process. Details regarding the histopathologic findings in breast tissue from patients undergoing female-to-male gender reassignment surgery are limited. We reviewed hematoxylin and eosin-stained sections of breast tissue from 148 patients who underwent breast reduction surgery or mastectomy as part of the female-to-male gender reassignment process at our institution between January 2014 and May 2017. Read More

Ann Dermatol Venereol 2018 Dec 6;145(12):773-776. Epub 2018 Oct 6.

Service de dermatologie et IST, CHU Sylvanus Olympio, BP 30785, Lomé, Togo.

Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs often used in the first-line treatment regimen of HIV1 infection worldwide. We report a case of successive gynecomastia and Stevens-Johnson syndrome (SJS) respectively induced by efavirenz and nevirapine in a single patient.

Case Report: A 16-year-old boy, HIV1-infected since birth, was started on antiretroviral treatment (ART) in August 2015 and was taking a regimen comprising abacavir, lamivudine and efavirenz. Read More

G Ital Dermatol Venereol 2018 Oct 3. Epub 2018 Oct 3.

Dermatology Department, University of Pisa, Pisa, Italy.

J Adolesc Health 2018 Dec 29;63(6):759-765. Epub 2018 Sep 29.

Adolescent Breast Clinic, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Plastic and Oral Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: Despite the psychosocial deficits associated with gynecomastia, surgical treatment of adolescent gynecomastia remains controversial. This longitudinal cohort study measures changes in health-related quality of life following surgical treatment of gynecomastia in adolescents.

Methods: The following surveys were administered to adolescents with gynecomastia and male controls, aged 12-21 years: Short-Form 36v2 (SF-36), Rosenberg Self-Esteem Scale (RSES), and Eating-Attitudes Test-26. Read More

F1000Res 2018 30;7:677. Epub 2018 May 30.

Marie-Curie Sklodowska University, Lublin, Poland.

Adverse drug reactions (ADRs) are a major cause of hospital admissions, prolonged hospital stays, morbidity, and drug-related mortality. In this study, we sought to identify the most frequently reported medications and associated side effects in adolescent-aged patients in an effort to prioritize clinical pharmacology consultation efforts for hospitals seeking to improve patient safety.   Quarterly reported data were obtained from the United States Food and Drug Administration Adverse Events Reporting System (FAERS) from the third quarter of 2014 and ending in the third quarter of 2017. Read More

Aesthetic Plast Surg 2018 Dec 26;42(6):1506-1518. Epub 2018 Sep 26.

Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, Rome, Italy.

Introduction: The objectives of this study are: (1) comparison of long-term outcomes after correction of severe gynecomastia using different techniques; (2) apply the Italian version of the BODY-Q; (3) present the role of intercostal perforator flap (ICAP) after massive weight loss for correction of severe gynecomastia.

Materials And Methods: Between January 2008 and March 2016, we performed surgical correction of bilateral severe gynecomastia in 80 men (160 breasts) following massive weight loss. Patients answered the Italian version of BODY-Q postoperative module. Read More

Plast Reconstr Surg 2018 10;142(4):908-909

Pittsburgh, Pa. From the Department of Plastic Surgery, University of Pittsburgh Medical Center.

Plast Reconstr Surg 2018 10;142(4):904-907

Austin, Texas From private practice.

Gynecomastia awareness and treatment have increased significantly. Treatment of gynecomastia is now one of the most popular procedures requested by men. There are many gynecomastia classification systems that have been described. Read More

J Mol Recognit 2019 Mar 24;32(3):e2764. Epub 2018 Sep 24.

Department of Chemistry and Research Institute of Natural Sciences, Hanyang University, Seoul, Republic of Korea.

Endocrine-disrupting chemicals are a major public health problem throughout the world. In the human body, these compounds functionalize the same as sexual hormones, inducing precocious puberty, gynecomastia, etc. To help prevent this occurrence, a simple detection system is needed. Read More

Oncology (Williston Park) 2018 09;32(9):470-4, CV3

The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). This therapy is associated with a multitude of side effects that can impact quality of life. These include vasomotor complications (in particular, hot flushes), sexual dysfunction and gynecomastia, osteoporosis, metabolic syndrome, and depression. Read More

Aesthetic Plast Surg 2018 Dec 17;42(6):1591-1599. Epub 2018 Sep 17.

A-Plast Estetik, Akasya AVM, A1 Kule, D:117Acıbadem, Istanbul, Turkey.

Introduction: Combined and/or multistage operations often are needed in postbariatric surgery.

Aim: With this retrospective study of a series of 55 cases, we aim to determine the effectiveness and safety of one-stage combined postbariatric surgery.

Materials And Methods: A total of 248 postbariatric procedures were performed in one session (except one-staged gynecomastia case) in 55 patients. Read More

Arch Argent Pediatr 2018 Oct;116(5):e655-e658

Unidad de Endocrinología Pediátrica, Hospital Universitario Reina Sofía (Córdoba), España.

Gynecomastia consists of breast enlargement due to a hormonal imbalance between estrogens and androgens. Unilateral and important breast growth requires ruling underlying pathologic disorders out. Mechanical cause is uncommon, causing enlargement by repeated stimulation. Read More

Plast Reconstr Surg 2018 Dec;142(6):1600-1608

Hamilton, Toronto, and Mississauga, Ontario, Canada; Odense and Esbjerg, Denmark; Eindhoven and Amsterdam, The Netherlands; Houston, Texas; New York, N.Y.; and Jyväskylä, Finland For the authors' affiliations, see the Appendix at the end of the article.

Background: Plastic surgery to improve chest appearance is becoming increasingly popular. The BODY-Q is a patient-reported outcome instrument designed for weight loss and/or body contouring. In this article, the authors describe the development of a new module for masculinizing chest contouring surgery. Read More

Heart Vessels 2019 Feb 10;34(2):279-289. Epub 2018 Sep 10.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Differences in the clinical impacts of the aldosterone receptor antagonists spironolactone and eplerenone in patients with heart failure (HF) are unclear. Among 838 prospectively enrolled patients hospitalized for HF, 90 treated with eplerenone were compared with 90 treated with spironolactone. The primary endpoint was a composite of cardiovascular death and hospitalization. Read More

Adv Radiat Oncol 2018 Jul-Sep;3(3):240-244. Epub 2018 Feb 26.

Department of Radiation Oncology, University of Muenster, Muenster, Germany.

Purpose: Radiation therapy (RT) is a common treatment for benign diseases in Germany. Because the treatment concepts are inconsistent, we conducted this pattern-of-care study on behalf of the German Cooperative Group on Benign Diseases to evaluate treatment standards in Germany.

Methods And Materials: Questionnaires were mailed to all radiation therapy facilities in Germany. Read More

J Plast Surg Hand Surg 2018 Sep 4:1-4. Epub 2018 Sep 4.

a Department of Plastic Surgery , Odense University Hospital , Odense , Denmark.

The aim of this study was to translate and linguistically validate the patient-reported outcome (PRO) instrument body-q chest module, designed to measure outcomes following chest contouring surgery. The BODY-Q Chest Module includes two scales that measure appearance of chest and nipples. The translation and validation were performed according to the guidelines from the world health organization (who) and the international society for pharmacoeconomics and outcomes research (ISPOR). Read More

Gland Surg 2018 Aug;7(Suppl 1):S70-S76

Department of Plastic Surgery, Odense University Hospital, Odense C, Denmark.

Gynecomastia affects up to two-thirds of the male population. For many patients the psychological impact of the disease is substantial. Surgical treatment is indicated when medical treatments fail. Read More

Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6.

Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Pediatric breast disease is uncommon, and primary breast carcinoma in children is extremely rare. Therefore, the approach used to address breast lesions in pediatric patients differs from that in adults in many ways. Knowledge of the normal imaging features at various stages of development and the characteristics of breast disease in the pediatric population can help the radiologist to make confident diagnoses and manage patients appropriately. Read More