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    4743 results match your criteria Gynecomastia

    1 OF 95

    Potential case of gynecomastia in mummified remains of an early modern period northern finnish vicar.
    Clin Anat 2018 Apr 17. Epub 2018 Apr 17.
    Archeology, Faculty of Humanities, POB 1000, FI-90014 University of Oulu.
    We report possibly the oldest evidence of gynecomastia in mummified human remains. Computed tomography was performed on the mummified remains of an early 17 century Northern Finnish vicar. The examination of the scans revealed large bilateral subareolar irregular masses resembling female mammary glands. Read More

    [A Case of Poorly Differentiated Carcinoma of Unknown Primary Site with Risk of Choriocarcinoma Syndrome Effectively Treated with Reduced Bleomycin,Cisplatin ,Etoposide Combination Regimen(BEP Regimen)].
    Gan To Kagaku Ryoho 2018 Apr;45(4):643-645
    Dept. of Hematology and Oncology, Mie University Hospital.
    A 64-year-old man visited his physician complaining of bilateral gynecomastia and left shoulder pain. Chest X-ray showed multiple bilateral masses in the lung, and he was referred to our hospital. Radiographical findings, elevation of serum total hCG, and histological findings of the cervical lymph node revealed multiple pulmonary, nodal, and brain metastases of poorly differentiated carcinoma of an unknown primary site with choriocarcinoma components. Read More

    Cimetidine: A Safe Treatment Option for Cutaneous Warts in Pediatric Heart Transplant Recipients.
    Med Sci (Basel) 2018 Apr 8;6(2). Epub 2018 Apr 8.
    Department of Pediatrics, UTSW Medical Center, Dallas, Texas 75235, USA.
    : Immunosuppressed individuals are at particularly increased risk for human papilloma virus-related infections. The primary objective of our study is to determine if there are any adverse effects associated with high-dose cimetidine treatment. A secondary objective is to report our experience with cimetidine in the treatment of cutaneous warts in pediatric heart transplant recipients. Read More

    Breast Abscess Mimicking Breast Carcinoma in Male.
    J Midlife Health 2018 Jan-Mar;9(1):39-40
    Department of Radiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Male breast can show almost all pathological entities described in female breast. Inflammatory conditions of the breast in male are not common; however, occasionally, it can be encountered in the form of an abscess. Clinically, gynecomastia always presents as a symmetric unilateral or bilateral lump in the retroareolar region, and any irregular asymmetric lump raises a possibility of malignancy. Read More

    Prevalence, clinical characteristics and long-term outcomes of classical 11 β-hydroxylase deficiency (11BOHD) in Turkish population and novel mutations in CYP11B1 gene.
    J Steroid Biochem Mol Biol 2018 Apr 4. Epub 2018 Apr 4.
    Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul, 34093, Turkey.
    Congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency (11BOHD) is a rare autosomal recessive disorder and the second most common form of CAH.

    Aim: To investigate genotype-phenotype correlation and to evaluate clinical characteristics and long-term outcomes of patients with 11BOHD.

    Methods: A total of 28 patients (n = 14, 46,XX; n = 14, 46,XY) with classical 11BOHD from 25 unrelated families were included in this study. Read More

    "Post-finasteride syndrome": what to tell our female patients?
    Br J Dermatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
    Postmarketing surveillance from men using finasteride, a 5-alpha reductase inhibitor (5ARI), for male pattern hair loss (MPHL) includes reports of various forms of sexual dysfunction, such as decreased libido, erectile and ejaculatory dysfunction, and gynecomastia. Purported mechanisms for these effects include the decreased production of neurosteroids, which may regulate sexual desire and function, and impaired testosterone metabolism, leading to relative estrogen excess. Large randomized controlled trials of men on 5ARIs for benign prostatic hypertrophy have shown increased sexual dysfunction compared to placebo; however, similar association with MPHL was not statistically significant. Read More

    Estrogen-induced myelotoxicity in a 4-year-old golden retriever dog due to a Sertoli cell tumor.
    Can Vet J 2018 Apr;59(4):425-427
    Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
    A 4-year-old, unilateral cryptorchid golden retriever dog was presented to the Ontario Veterinary College Health Sciences Centre with gynecomastia, dribbling urine, lethargy, neutropenia, and thrombocytopenia. A Sertoli cell tumor was diagnosed in a cryptorchid testicle with estrogen-induced myelotoxicity. The tumor was removed and bone marrow regenerated within 4 months. Read More

    Estrogen: The necessary evil for human health, and ways to tame it.
    Biomed Pharmacother 2018 Mar 21;102:403-411. Epub 2018 Mar 21.
    Department of Botany, Berhampur University, Berhampur, Odisha, 760007, India.
    Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, autoimmune, metabolic to degenerative. Read More

    Spironolactone-Induced Unilateral Gynecomastia.
    Int J Appl Basic Med Res 2018 Jan-Mar;8(1):45-47
    Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
    Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Read More

    Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynaecomastia.
    Aesthetic Plast Surg 2018 Mar 16. Epub 2018 Mar 16.
    Department of Hand and Plastic Surgery, Burn Centre, Linköping University Hospital, 58185, Linköping, Sweden.
    Background: Gynaecomastia is a benign enlargement of the male breast, of which the psychological burden on the patient can be considerable, with the increased risk of disorders such as depression, anxiety, and social phobia. Minimal scarring can be achieved by liposuction alone, though it is known to have a limited effect on the dense glandular and fibroconnective tissues. We know of few studies published on "liposuction alone", so we designed this study to evaluate the outcome of combining liposuction with glandular liposculpturing through two axillary incisions as a single treatment for the management of grades I and II gynaecomastia. Read More

    Does Prophylactic Radiation Therapy to Avoid Gynecomastia in Patients With Prostate Cancer Increase the Risk of Breast Cancer?
    Int J Radiat Oncol Biol Phys 2018 May 5;101(1):211-216. Epub 2018 Feb 5.
    Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway.
    Purpose: Prostate cancer (PC) patients who undergo antiandrogen monotherapy are offered prophylactic radiation therapy (PRT) to the breast buds to avoid gynecomastia. The aim of the present study was to evaluate whether the risk of breast cancer (BC) in men with PC as their first cancer diagnosis was influenced by PRT.

    Methods And Materials: From the Norwegian Cancer Registry, we collected data from all patients with PC as their first cancer diagnosis from 1997 to 2014. Read More

    Hypertrophic osteoarthropathy: estrogens, prostaglandinE, prostaglandin A, and the inflammatory reflex.
    Clin Rheumatol 2018 Feb 26. Epub 2018 Feb 26.
    Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
    It has been claimed that hyperestrogenism occurs in hypertrophic osteoarthropathy (HOA), but not in simple clubbing. However, one of our patients had simple clubbing and hyperestrogenism. We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing. Read More

    Clinical Characteristics of Asymmetric Bilateral Gynecomastia: Suggestion of Desirable Surgical Method Based on a Single-Institution Experience.
    Aesthetic Plast Surg 2018 Feb 20. Epub 2018 Feb 20.
    Department of Surgery, Damsoyu Hospital, Central Tower 5-9F, Bongeunsa-ro 213, Gangnam-gu, Seoul, Republic of Korea.
    Background: Asymmetric bilateral gynecomastia (ABGM) is uncommon, and reports on its characteristics are rare. In the present study, we investigated the clinical characteristics and surgical treatment of ABGM.

    Methods: We conducted a retrospective study of 1159 patients with gynecomastia who underwent subcutaneous mastectomy with liposuction at Damsoyu Hospital from January 2014 to February 2016. Read More

    The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.
    J Neurol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
    Objective: Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for the selection of biomarkers for future therapeutic trials.

    Methods: We assessed a panel of 28 laboratory parameters. Read More

    [The forensic medical characteristic of sudden death associated with metabolic syndrome].
    Sud Med Ekspert 2018 ;61(1):60-64
    Bureau of forensic medical expertise, Moscow Health Department, Moscow, Russia, 115516.
    The detection of grade II-III central obesity on a corpse in conjunction with the identification of two additional criteria (such as arterial hypertension and impaired glucose tolerance) provides, if combined with the autopsy data (including the visual reduction of muscular mass, the increased total amount of the adipose tissue, gynecomastia in men together with hypertrophied abdominal adipose tissue accumulation, decreased face and body pilosis), a basis for diagnostics of metabolic syndrome (MS). The objective parameters for this purpose are waist circumference measurements, corpse weight and height, the degree of visceral obesity, narrowing of the renal arteries as a result of their compression by the surrounding adipose tissue, and accumulation of epicardial fat confirmed by the results of the biochemical analysis. The signs of plasmorrhagia combined with fibrinoid degeneration of the vascular walls in the microcirculatory bed make it possible to suspect, with a high degree of probability, the development of hypertensive crisis that may result in a sudden death of the patients presenting with metabolic syndrome. Read More

    Adrenocortical carcinoma characterized by gynecomastia: A case report.
    Clin Pediatr Endocrinol 2018 30;27(1):9-18. Epub 2018 Jan 30.
    Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
    We present a 4-yr-old boy with adrenocortical carcinoma (ACC), diagnosed due to the appearance of gynecomastia as the presenting symptom. Six months prior to admission, an acute growth spurt along with the development of bilateral breast swelling was observed. He did not present any features of virilization, including enlargement of the testes, increase in testis volume, and penis size. Read More

    Changing practices: The addition of a novel surgical approach to gynecomastia.
    Am J Surg 2018 Jan 29. Epub 2018 Jan 29.
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Surgical Services, John L. McClellan Memorial Veterans Hospital, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. Electronic address:
    Introduction: Gynecomastia can be a significant impediment to quality of life for men who suffer from this affliction. Numerous surgical techniques have been described in the literature ranging from minimally invasive options such as liposuction to incision based reductions. The standard for the general surgeons at our institution has been subcutaneous mastectomy through a circumareolar incision, which often proved inadequate for patients with grade II or III gynecomastia. Read More

    Ugeskr Laeger 2018 01;180(4)
    Gynaecomastia (GM) is a benign proliferation of the glandular tissue of the male breast and results from an imbalance between androgen and oestrogen. Pubertal GM is found in 50% and often resolves spontaneously without treatment. GM in adult men can be the first symptom of an underlying disease, and thorough investigation is recommended. Read More

    Recovery from reproductive impact of androgen abuse.
    Curr Opin Endocrinol Diabetes Obes 2018 Jan 31. Epub 2018 Jan 31.
    Department of Endocrinology, University of Ioannina, Ioannina, Greece.
    Purpose Of Review: To summarize recent data on the adverse reproductive consequences of androgen abuse, focusing on the recovery of reproductive function following androgen discontinuation.

    Recent Findings: Evidence is mostly based on case reports and observational studies. Androgen abuse leads to a state of hypogonadotropic hypogonadism associated with impaired spermatogenesis, testicular atrophy, gynecomastia as well as menstrual irregularities, virilization and subfertility. Read More

    Klinefelter syndrome: more than hypogonadism.
    Metabolism 2018 Jan 31. Epub 2018 Jan 31.
    University Hospital of Muenster, Center of Reproductive Medicine and Andrology, Domagkstraße 11, D-48149, Muenster, Germany.
    Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Read More

    Evidence-Based Practice in Liposuction.
    Ann Plast Surg 2018 Jan 24. Epub 2018 Jan 24.
    Background: The goal of this study is to examine the existing peer reviewed literature comparing modern adjunctive techniques in liposuction including laser-assisted liposuction (LAL) and ultrasound-assisted liposuction (UAL) to standard suction-assisted liposuction (SAL). We intend to interpret these findings into a literature-based clinical application to influence practice patterns.

    Methods: A literature review was conducted using a keyword search in PubMed. Read More

    Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys.
    Eur J Cancer 2018 Mar;91:125-135
    Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina. Electronic address:
    Leydig-cell tumours (LCTs) are rare endocrine tumours of the testicular interstitium, with recent increased incidence. Symptoms include precocious puberty in children; and erectile dysfunction, infertility and/or gynaecomastia, in adults. So far, scientific evidence points to aromatase (CYP19) overexpression and excessive oestrogen and insulin-like growth factor (IGF) -1 production as responsible for Leydig-cell tumourigenesis. Read More

    Finasteride topical delivery systems for androgenetic alopecia.
    Curr Drug Deliv 2018 Jan 23. Epub 2018 Jan 23.
    Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad. Pakistan.
    Androgenetic alopecia, generally recognized as male pattern baldness, is a gradually developing medical and physiological change, which is manifested by continuous hair-loss from scalp. Finasteride (4-aza-3-oxosteroid) is a potent anti-baldness compound that selectively and competitively inhibits the 5α-reductase isoenzymes. Prolonged oral use of finasteride leads to the emergence of sexual disorders including decrease in libido, gynecomastia, erectile dysfunction, ejaculation disorder, orgasm disorders and mood disturbances. Read More

    Next Generation Sequencing expression profiling of mitochondrial subunits in men with Klinefelter syndrome.
    Int J Med Sci 2018 1;15(1):31-35. Epub 2018 Jan 1.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    Klinefelter syndrome (KS) is one of the most common sex-chromosome disorders as it affects up to 1 in every 600-1000 newborn males. Men with KS carry one extra X chromosome and they usually present a 47,XXY karyotype, but less frequent variants have also been reported in literature. KS typical symptoms include tall stature, gynecomastia, broad hips, hypogonadism and absent spermatogenesis. Read More

    [Primary breast diffuse large B-cell lymphoma developing subsequent to estramustine therapy for prostate cancer].
    Rinsho Ketsueki 2017;58(12):2411-2413
    Hematology, University of Occupational and Environmental Health.
    An 85-year-old male presented with 1-year history of a right breast mass. Needle biopsy of the mass revealed diffuse proliferation of large lymphoid cells that were positive for CD20, BCL2, BCL6, and MUM1 and negative for CD5, CD10, MYC, and EBER. The patient was diagnosed as having diffuse large B-cell lymphoma, a type of primary breast lymphoma (PBL). Read More

    The unusual suspects: A review of unusual benign and malignant male breast imaging cases.
    Clin Imaging 2017 Dec 28;50:78-85. Epub 2017 Dec 28.
    Columbia University Medical Center Department of Radiology, Herbert Irving Pavilion, 161 Fort Washington Ave, New York, NY 10032, United States. Electronic address:
    Male breast disease is uncommon. Men presenting with breast symptoms may represent unique diagnostic challenges for the radiologist, particularly if imaging findings are not classic for gynecomastia or carcinoma. In this paper we review 10 unusual male breast cases, 5 benign and 5 malignant, including the radiologic findings, differential diagnosis, pathology and management. Read More

    Quantitative CT Assessment of Gynecomastia in the General Population and in Dialysis, Cirrhotic, and Obese Patients.
    Acad Radiol 2018 Jan 8. Epub 2018 Jan 8.
    Department of Radiology, The Chaim Sheba Medical Center, Tel Hashomer, Emek HaEla St 1, Ramat Gan 5265601, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Chaim Levanon St 30, Tel-Aviv 6997801, Israel.
    Rationale And Objectives: Gynecomastia is the benign enlargement of the male breast because of proliferation of the glandular component. To date, there is no radiological definition of gynecomastia and no quantitative evaluation of breast glandular tissues in the general male population. The aims of this study were to supply radiological-based measurements of breast glandular tissue in the general male population, to quantitatively assess the prevalence of gynecomastia according to age by decades, and to evaluate associations between gynecomastia and obesity, cirrhosis, and dialysis. Read More

    Efficiency of Imaging Modalities in Male Breast Disease: Can Ultrasound Give Additional Information for Assessment of Gynecomastia Evolution?
    Eur J Breast Health 2018 Jan 1;14(1):29-34. Epub 2018 Jan 1.
    Department of Radiology, Taksim Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.
    Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia.

    Materials And Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia. Read More

    Managing Male Mammary Maladies.
    Eur J Breast Health 2018 Jan 1;14(1):5-9. Epub 2018 Jan 1.
    Department of Research Oncology, Guy's Hospital, London, England.
    This review examines the symptoms, need for referral and management of the benign breast conditions which afflict males, together with the steps that are necessary to exclude or confirm male breast cancer. The most common complaint is gynaecomastia, either true or pseudo, and the majority of these cases need reassurance without over-investigation. Drugs that induce breast enlargement are described in order that, when possible, a medication switch can be made. Read More

    Discussion on "Gynecomastia Surgery-Impact on Life Quality: A prospective Case-Control Study".
    Ann Plast Surg 2018 Feb;80(2):193-194
    Department of Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy; Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy.

    Ultrasonographic assessment of male breast diseases.
    Breast J 2018 Jan 8. Epub 2018 Jan 8.
    Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
    Although rare and accounting for less than 1% of all breast cancers, the incidence of breast cancer in men has increased by 26% over the past few decades. Very little has been reported on the sonographic appearance of benign and malignant male breast conditions. The aim of this study was to describe the ultrasonographic features of male breast disease and the value of ultrasound in the evaluation of male breast disease. Read More

    A boy with 46,X,+mar presenting gynecomastia and short stature.
    Ann Pediatr Endocrinol Metab 2017 12 31;22(4):266-271. Epub 2017 Dec 31.
    Division of Pediatric Endocrinology, Department of Pediatrics, Endocrine Research Institute, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
    A 15-year-old boy was referred due to gynecomastia and short stature. He was overweight and showed the knuckle-dimple sign on the left hand, a short fourth toe on the left foot, and male external genitalia with a small phallus. His levels of estradiol and follicle-stimulating hormone were increased, and his testosterone concentration was normal. Read More

    Daily subcutaneous testosterone for management of testosterone deficiency.
    Front Biosci (Elite Ed) 2018 Mar 1;10:334-343. Epub 2018 Mar 1.
    Djehuty Biomed Consulting, 106 Rugged Dr., Red Oak, TX 75154.
    Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects including, infertility, testicular atrophy, erythropoiesis, and gynecomastia. Read More

    Treatment of Paraphilic Disorders in Sexual Offenders or Men With a Risk of Sexual Offending With Luteinizing Hormone-Releasing Hormone Agonists: An Updated Systematic Review.
    J Sex Med 2018 Jan;15(1):77-93
    Institute for Sex Research and Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:
    Background: Different pharmacologic agents are used in the treatment of paraphilic disorders in sexual offenders or men with a risk of sexual offending, with luteinizing hormone-releasing hormone (LHRH) agonists being the agents introduced more recently to treatment regimens.

    Aim: To summarize the relevant literature concerning LHRH agonist treatment of paraphilic disorders in sexual offenders and update the previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890-897).

    Methods: The PubMed and Google Scholar databases were searched for literature published from January 2003 through October 2017 using the following key words: LHRH agonists, GnRH agonists, antiandrogens AND paraphilia, pedophilia, sex offenders. Read More

    [A POEMS syndrome revealed by a blue toe syndrome].
    Rev Med Interne 2018 Feb 26;39(2):127-129. Epub 2017 Dec 26.
    Service de médecine vasculaire, hôpitaux de Brabois, CHRU de Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm UMR-S 1116, université de Lorraine, 54000 Nancy, France.
    Introduction: Arterial and venous thromboses occur in almost one in five patients with POEMS syndrome and usually in macrocirculation.

    Case Report: We report a 67-year-old male with a POEMS syndrome who presented initially with a blue toe syndrome. He complained of Raynaud's syndrome and left foot paresthesia. Read More

    Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do They Reduce Complications? A Different Approach.
    Aesthetic Plast Surg 2017 Dec 20. Epub 2017 Dec 20.
    Plastic, Reconstructive and Cosmetic and Burn Surgery Unit, Hôpital Saint Louis, 1 Avenue Vellefaux, 75010, Paris, France.
    Introduction: We read the manuscript entitled "Closed-suction drains after subcutaneous mastectomy for gynecomastia: do they reduce complications? » published by Chao et al. (Aesthetic Plast Surg, 2017. https://doi. Read More

    Identification of the Underlying Androgen Receptor Defect in the Dallas Reifenstein Family.
    J Endocr Soc 2017 Jul 19;1(7):836-842. Epub 2017 May 19.
    Division of Endocrinology and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390.
    Context: The Dallas Reifenstein family - first described in 1965 - includes 14 known members with partial androgen insensitivity syndrome (PAIS). However, the underlying molecular defect was never identified.

    Objective: To identify the underlying genetic defect for PAIS in the Dallas Reifenstein family. Read More

    Hormonal treatment and quality of life of prostate cancer patients: new evidence.
    Minerva Urol Nefrol 2018 Apr 14;70(2):144-151. Epub 2017 Dec 14.
    Division of Medical Oncology, Ordine Mauriziano Hospital, Department of Oncology, University of Turin, Turin, Italy.
    Androgen deprivation therapy (ADT) is the mainstay of treatment of patients with relapsed or metastatic hormone-sensitive prostatic carcinoma. The dramatic reduction of serum testosterone levels induced by ADT produces multiple side effects as vasomotor flushing, sexual dysfunction, fatigue, impairment of cognitive function, reduced quality of sleep, gynecomastia and anemia, that are able to decrease health-related quality of life (QoL). In addition, hormonal therapy can interfere with bone metabolism and induce metabolic and cardiovascular complications. Read More

    Sellar plasmacytoma presenting with symptoms of anterior pituitary dysfunction.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 Nov 24.
    Endocrinology and Diabetes Department, Garcia de Orta Hospital, Almada, Portugal.
    Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. Read More

    Which patients with gynaecomastia require more detailed investigation?
    Clin Endocrinol (Oxf) 2018 Mar 21;88(3):360-363. Epub 2017 Dec 21.
    Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK.
    Gynaecomastia may be due to medication, chronic liver or kidney disease, hypogonadism (primary or secondary to pituitary disease) or hyperthyroidism. Having excluded these aetiologies, it is imperative to be vigilant for underlying malignancy causing gynaecomastia. These include human chorionic gonadotrophin-secreting testicular and extratesticular tumours and oestrogen-secreting testicular tumours and feminising adrenal tumours. Read More

    Discontinuation of Efavirenz in Paediatric Patients: Why do Children Switch?
    Clin Drug Investig 2018 Mar;38(3):231-238
    The Family Clinic, Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London, UK.
    Background: Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) is used globally as first-line antiretroviral therapy (ART) in combination with a dual nucleoside backbone in adults and children from 3 years of age. Up to 40% of adults taking efavirenz report central nervous system (CNS) adverse effects, and the rates of discontinuation of efavirenz-based treatment are higher than other first-line regimens. Data on efavirenz discontinuation are more limited for children and adolescents. Read More

    Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma.
    Clin Nucl Med 2018 Jan;43(1):41-43
    We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy. Read More

    A journey through liposuction and liposculture: Review.
    Ann Med Surg (Lond) 2017 Dec 6;24:53-60. Epub 2017 Nov 6.
    Department of Medicine and Surgery, Plastic Surgery Section, University of Parma, Cutaneous, Mini-invasive, Regenerative and Plastic Surgery Unit, Parma University Hospital, Parma, Italy.
    Introduction: Nowadays, liposuction is the most frequently performed aesthetic surgery procedure in Western Countries. This technique has had rapid development since the 1970s, when it was experimented for the first time by A. and G. Read More

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