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    1 OF 94

    Prolactinoma in a Dog.
    Vet Pathol 2017 Jan 1:300985817726118. Epub 2017 Jan 1.
    6 Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
    A 12-year-old male Yorkshire Terrier was presented because of decreased appetite. Physical examination revealed mammary gland swelling and galactorrhea. Contrast-enhanced computed tomographic scanning of the skull indicated an enlarged pituitary gland, compatible with a pituitary tumor. Read More

    Delayed Diagnosis of Acromegaly in the Context of Post-Traumatic Stress Disorder due to Symptoms Mimicking Known Psychotropic Medication Side Effects.
    Mil Med 2017 Jul;182(7):e1957-e1962
    Naval Hospital Bremerton, 1 Boone Road, Bremerton, WA 98312.
    Background: Acromegaly is caused by elevated secretion of human growth hormone, which is frequently because of intracranial tumors. This diagnosis is fairly uncommon with an incidence of 3 to 4 cases per million patients per year. We are presenting a case of acromegaly diagnosed in an active duty Chief Petty Officer. Read More

    Feminizing Adrenocortical Carcinoma Without Gynecomastia.
    Oman Med J 2017 Jul;32(4):349-351
    Department of Pathology, Benimessous Teaching Hospital, Algiers, Algeria.
    Malignant feminizing adrenocortical tumors are exceedingly rare. Their main presentation is gynecomastia. In these estrogen secreting tumors (with or without other adrenocortical hormones) lack of gynecomastia is exceptional as in our case. Read More

    Comment to "Orange Peel Excision of Gland: A Novel Surgical Technique for Treatment of Gynecomastia".
    Ann Plast Surg 2017 Sep;79(3):326
    Department of Plastic and Reconstructive Microsurgery, Careggi Universital Hospital, Florence, Italy. Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy Department of Plastic and Reconstructive Microsurgery, Careggi Universital Hospital, Florence, Italy.

    High rates of viral suppression in adults and children with high CD4+ counts using a streamlined ART delivery model in the SEARCH trial in rural Uganda and Kenya.
    J Int AIDS Soc 2017 Jul;20(Suppl 4):58-67
    Division of HIV, Infectious Diseases & Global Medicine, University of California, San Francisco, CA, USA.
    Introduction: The 2015 WHO recommendation of antiretroviral therapy (ART) for all HIV-positive persons calls for treatment initiation in millions of persons newly eligible with high CD4+ counts. Efficient and effective care models are urgently needed for this population. We evaluated clinical outcomes of asymptomatic HIV-positive adults and children starting ART with high CD4+ counts using a novel streamlined care model in rural Uganda and Kenya. Read More

    Gynecomastia: glandular-liposculpture through a single transaxillary one hole incision.
    J Plast Surg Hand Surg 2017 Jul 30:1-9. Epub 2017 Jul 30.
    b Department of Plastic Surgery , College of Medicine, Kyung Hee University , Seoul , Republic of Korea.
    Gynecomastia is characterized by the benign proliferation of breast tissue in men. Herein, we present a new method for the treatment of gynecomastia, using ultrasound-assisted liposuction with both conventional and reverse-cutting edge tip cannulas in combination with a pull-through lipectomy technique with pituitary forceps through a single transaxillary incision. Thirty patients were treated with this technique at the author's institution from January 2010 to January 2015. Read More

    Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications.
    Hormones (Athens) 2017 Apr;16(2):115-123
    Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
    Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone production which interrupts testosterone-induced growth of the prostate tumor. The dramatic decrease in testosterone levels, however, has several undesirable effects on the metabolic profile and bone metabolism and can also lead to fatigue, loss of libido, gynecomastia, and anemia, provoke vasomotor flushing, and generally affect the quality of life. Read More

    Breast disease in men in metropolitan São Paulo - Brazil.
    Breast J 2017 Jul 25. Epub 2017 Jul 25.
    Faculdade de Medicina do ABC e Hospital Municipal Universitário, São Paulo, Brazil.
    Although rare, breast cancer in males represents 1% of all cancer in men, and has shown increasing incidence in 25 years. To analyze age, gender, type of procedure performed and diagnosis of all cases of breast diseases in a public hospital in Sao Paulo, Brazil, with special focus on men. Cross-sectional study of breast surgery in 2010-2014 at Hospital Municipal Universitario de Sao Bernardo do Campo, Brazil. Read More

    Optimal Positioning of the Nipple-Areola Complex in Men Using the Mohrenheim-Estimated-Tangential-Tracking-Line (METT-Line): An Intuitive Approach.
    Aesthetic Plast Surg 2017 Jul 19. Epub 2017 Jul 19.
    Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
    Introduction: The reconstruction of the body shape after post-bariatric surgery or high-grade gynecomastia involves, besides skin tightening, the repositioning of anatomical, apparent landmarks. The surgeon usually defines these during the preoperative planning. In particular, the positions of the nipple-areola complexes (NAC) should contribute to the gender-appropriate appearance. Read More

    A Systematic Review and Framework for the Use of Hormone Therapy with Salvage Radiation Therapy for Recurrent Prostate Cancer.
    Eur Urol 2017 Jul 14. Epub 2017 Jul 14.
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
    Context: Salvage radiotherapy (SRT) is a standard of care for men who recur postprostatectomy, and recent randomized trials have assessed the benefit and toxicity of adding hormone therapy (HT) to SRT with differing results.

    Objective: To perform a systematic review of randomized phase III trials of the use of SRT ± HT and generate a framework for the use of HT with SRT.

    Evidence Acquisition: Systematic literature searches were conducted on February 15, 2017 in three databases (MEDLINE [via PubMed], EMBASE, and ClinicalTrials. Read More

    Reply to the Comment on: Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases.
    Ann Plast Surg 2017 Aug;79(2):226-227
    Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy. Department of Plastic and Reconstructive Surgery, University of Bari, Foggia, Italy; Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy.

    From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet?
    Mol Cell Endocrinol 2017 Jul 5. Epub 2017 Jul 5.
    Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK. Electronic address:
    Abnormal polyglutamine expansions in the androgen receptor (AR) cause a muscular condition, known as Kennedy's disease or spinal and bulbar muscular atrophy (SBMA). The disease is transmitted in an X-linked fashion and is clinically characterized by weakness, atrophy and fasciculations of the limb and bulbar muscles as a result of a toxic gain-of-function of the mutant protein. Notably, affected males also show signs of androgen insensitivity, such as gynaecomastia and reduced fertility. Read More

    False Positive Uptake in Bilateral Gynecomastia on 68Ga-PSMA PET/CT Scan.
    Clin Nucl Med 2017 Sep;42(9):e412-e414
    From the *KIMS-DDNMRC, and †KIMS Hospital, Thiruvananthapuram, Kerala, India.
    A 66-year-old man on hormonal therapy with prostate cancer was referred for Ga-PSMA PET/CT scan for biochemical recurrence. Ga-PSMA PET/CT scan detected moderate heterogeneous tracer concentration in bilateral breast parenchyma, in addition to the abnormal tracer concentration in enlarged prostate gland, right external iliac lymph node, and sclerotic lesion in L4 vertebra. On clinical examination, he was found to have bilateral gynecomastia. Read More

    Discussion on "Reduction of the Areolar Diameter After Ultrasound-Assisted Liposuction for Gynecomastia".
    Ann Plast Surg 2017 Jun 23. Epub 2017 Jun 23.
    Plastic and Reconstructive Microsurgery Careggi University Hospital Florence, Italy Plastic and Reconstructive Microsurgery Careggi University Hospital Florence, Italy Department of Plastic and Reconstructive Surgery University of Bari Foggia, Italy.

    Value of diagnostic imaging for the symptomatic male breast: Can we avoid unnecessary biopsies?
    Clin Imaging 2017 Jun 9;45:86-91. Epub 2017 Jun 9.
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA.
    Purpose: To review the use of diagnostic breast imaging and outcomes for symptomatic male patients.

    Methods: We retrospectively evaluated 122 males who underwent diagnostic imaging for breast symptoms at our academic center.

    Results: The majority (94%) of cases had negative or benign imaging, with gynecomastia being the most common diagnosis (78%). Read More

    Discussion: Gynecomastia classification for surgical management: A systematic review and novel classification system.
    Plast Reconstr Surg 2017 Jun 14. Epub 2017 Jun 14.
    1. Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. 2. Division of Plastic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada. 3. Surgical Outcomes Research Center, Department of Surgery, McMaster, University, Hamilton, Ontario, Canada 4. Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

    Discussion: Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System.
    Plast Reconstr Surg 2017 Jun 14. Epub 2017 Jun 14.
    1 Department of Plastic and Reconstructive Surgery, University of Bari, Italy 2 Plastic and Reconstructive Microsurgery, Careggi Universital Hospital, Florence, Italy 3 Department of Plastic and Reconstructive Surgery, University of Foggia, Italy.

    Adolescent Gynecomastia.
    Pediatr Endocrinol Rev 2017 Jun;14(4):371-377
    Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, MA, USA.
    Gynecomastia, defined as the presence of glandular breast tissue in men, is a common, typically benign physical exam finding during adolescence. Although the exact pathogenesis of gynecomastia is unknown, it is likely due to a hormonal imbalance between estrogens and androgens. Most cases are idiopathic and do not require further evaluation if the history and physical examination are reassuring. Read More

    Pubertal gynecomastia: years of progress - the Hacettepe experience.
    Int J Adolesc Med Health 2017 Jun 9. Epub 2017 Jun 9.
    .
    Gynecomastia is defined as an enlargement of the male breast. Although it is commonly seen during puberty, it is often overlooked by many physicians. As adolescent medicine specialists, we believe there is a gap in the literature concerning both the etiology and maybe more importantly the care of these adolescents. Read More

    Analysis of risk factors associated with unplanned reoperations following pediatric plastic surgery.
    J Plast Reconstr Aesthet Surg 2017 May 18. Epub 2017 May 18.
    Baylor College of Medicine, Houston, TX, USA. Electronic address:
    Background/purpose: Unplanned reoperation (UR) is an outcome measure with multiple advantages that can be used as a standardized tool to assess an institution's quality and safety of medical care. This study aimed to identify parameters associated with an increased likelihood of UR following plastic surgery in patients less than 18 years of age by using a large validated national multicenter database.

    Methods/description: We performed a retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Pediatric database between 2012 and 2014 to identify pediatric patients undergoing primary plastic surgery procedures. Read More

    Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male.
    BMJ Case Rep 2017 Jun 5;2017. Epub 2017 Jun 5.
    Department of Endocrinology, Aga Khan University Hospital, Karachi, Pakistan.
    A 34-year-old male presented to the endocrinology clinic with the complaint of the absence of facial, axillary and pubic hairs. Further history revealed absent ejaculations and decreased early morning erections. The patient had no history of headaches, visual problems or anosmia. Read More

    Differential efficacy profile of aldosterone receptor antagonists, depending on the type of chronic heart failure, whether with reduced or preserved left ventricular ejection fraction-results of a meta-analysis of randomized controlled trials.
    Cardiovasc Diagn Ther 2017 Jun;7(3):272-287
    Geriatric Department, Casa di Cura "S.Maria del Pozzo", Somma Vesuviana (Napoli), Italy.
    Background: Because of renin-angiotensin-aldosterone system (RAAS) activation, the patients with chronic heart failure (CHF) manifest increased ventricular stress, with impaired left ventricular function, and a slowing down in systemic venous drainage. More importantly, a reduction of the patient's life expectancy has been proven in the case of RAAS overstimulation. For these reasons, huge efforts have been made to obtain molecules able to efficaciously antagonize the RAAS overstimulation, such as aldosterone receptor antagonists (ARAs). Read More

    Peutz-Jeghers syndrome with early onset of pre-adolescent gynecomastia: a predigree case report and clinical and molecular genetic analysis.
    Am J Transl Res 2017 15;9(5):2639-2644. Epub 2017 May 15.
    Department of Endocrine, Shenzhen Children's HospitalNo. 7019 Yitian Road, Futian District, Shenzhen 518000, Guangdong, China.
    This study reports a case of Peutz-Jeghers syndrome with early onset of gynecomastia, and discusses its clinical characteristics and genetic changes in a family. The clinical characteristics of a child diagnosed with Peutz-Jeghers syndrome in our hospital and his parents were summarized, and related genes were detected in the child and his parents. Furthermore, the therapeutic effect of letrozole was also observed. Read More

    Increased F-FDG Uptake in Bilateral Gynecomastia Secondary to Feminizing Adrenal Tumor: A Rare Case Report and Review of Literature.
    Indian J Nucl Med 2017 Apr-Jun;32(2):145-147
    Radiation Medicine Centre, Bhabha Atomic Research Centre, TMC Annexe, Jerbai Wadia Road, Parel, Mumbai, India.
    A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. Read More

    Kennedy disease with difficulty in differential diagnosis: A case report.
    Medicine (Baltimore) 2017 May;96(19):e6792
    Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
    Rationale: Kennedy disease (KD) is also known as spinal bulbar muscular dystrophy. As KD has similar symptoms with most neuromuscular diseases, so it is difficult to make a rapid diagnosis clinically.

    Patient Concerns: We report a case of a 43-year-old male with progressive limb proximal weakness without family history. Read More

    Fragrance compounds: The wolves in sheep's clothings.
    Med Hypotheses 2017 May 22;102:106-111. Epub 2017 Mar 22.
    Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego 92182, USA. Electronic address:
    In the past few decades, synthetic fragrance compounds have become ubiquitous components of personal care and household cleaning products. Overwhelming consumerism trends have led to the excess usage of these chemicals. It has been observed that this fragrance-laden unhealthy lifestyle runs parallel with the unprecedented rates of diabetes, cancer, neural ailments, teratogenicity, and transgender instances. Read More

    Kennedy disease (X-linked recessive bulbospinal neuronopathy): A comprehensive review from pathophysiology to therapy.
    Rev Neurol (Paris) 2017 May 1;173(5):326-337. Epub 2017 May 1.
    Laboratoire d'imagerie biomédicale, Sorbonne universités, UPMC University Paris 06, CNRS, Inserm, 75013 Paris, France; Département des maladies du système nerveux, hôpital Pitié-Salpêtriere, centre référent-SLA, AP-HP, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address:
    Kennedy's disease, also known as spinal and bulbar muscular atrophy (SBMA), is a rare, adult-onset, X-linked recessive neuromuscular disease caused by expansion of a CAG repeat sequence in exon 1 of the androgen receptor gene (AR) encoding a polyglutamine (polyQ) tract. The polyQ-expanded AR accumulates in nuclei, and initiates degeneration and loss of motor neurons and dorsal root ganglia. While the disease has long been considered a pure lower motor neuron disease, recently, the presence of major hyper-creatine-kinase (CK)-emia and myopathic alterations on muscle biopsy has suggested the presence of a primary myopathy underlying a wide range of clinical manifestations. Read More

    Is the transposition of the nipple-areolar complex necessary in Simon grade 2b gynecomastia operations using suction-assisted liposuction?
    J Plast Surg Hand Surg 2017 May 4:1-7. Epub 2017 May 4.
    a Department of Plastic, Reconstructive and Aesthetic Surgery, Dicle Medical Faculty , Dicle University , Diyarbakır , Turkey.
    Objective: The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance.

    Methods: A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and postoperative SNN distances of the patients were measured, the results were analysed using a Mann-Whitney U test and a p-value <. Read More

    The Characteristics and Short-Term Surgical Outcomes of Adolescent Gynecomastia.
    Aesthetic Plast Surg 2017 Apr 27. Epub 2017 Apr 27.
    Department of Surgery, Damsoyu Hospital, 213 Bongeunsa-ro, Gangnam-gu, Seoul, Korea.
    Background: Most adolescent gynecomastia is resolved spontaneously in 3 years. But, persistent gynecomastia could have a negative influence on psychoemotional development on adolescence. The purpose of this study is to report the characteristics of adolescent gynecomastia patients who received the surgeries, and discuss the short-term surgical outcomes. Read More

    Multiple symmetric lipomatosis and gynecomastia: A case report and relative literature review.
    J Clin Lipidol 2017 May - Jun;11(3):763-767. Epub 2017 Mar 30.
    Department of Endocrinology, The Third Hospital of Hebei Medical University, ShiJiazhuang, Hebei Province, China.
    Multiple symmetric lipomatosis is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk, and limbs. Here, we reported an extremely rare case of multiple symmetric lipomatosis in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. Read More

    Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas.
    Mod Pathol 2017 Jul 21;30(7):908-918. Epub 2017 Apr 21.
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered an additional five testicular and nine ovarian cases. One tumor occurred in a 60-year-old man, but all others occurred within the typical age range of gonadal germ cell tumors. Read More

    Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion.
    Case Rep Oncol Med 2017 21;2017:5172072. Epub 2017 Mar 21.
    Department of General Surgery, Larkin Community Hospital, South Miami, FL, USA.
    There has been an increasing use of hormonal therapy among male-to-female (MtF) transgender individuals. This long-term hormone replacement therapy (HRT) renders MtF individuals a unique patient subgroup in terms of breast cancer risk. This case describes a MtF transgender who presented with a breast lesion concerning for malignancy following hormonal replacement therapy. Read More

    Ovotestis in Adolescence: 2 Case Reports.
    Urology 2017 Jul 13;105:171-174. Epub 2017 Apr 13.
    Division of Urology, Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address:
    We present 2 patients found to have ovotesticular disorder of sexual development (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: 1 with concern for testicular rupture after a straddle injury; 1 with gynecomastia. Further workup, including imaging and laboratory tests, was performed before surgical exploration. Read More

    Paul of Aegina (ca 625-690 ad), Reconstructing Male Gynecomastia.
    Surg Innov 2017 Jun 8;24(3):299-300. Epub 2017 Mar 8.
    1 University of Thessaly, Larissa, Greece.
    Paul of Aegina thrived with his innovative operations, practically creating a kind of a new surgical school. He had deeply believed in human's body perfection introducing a series of cosmetic operations. Among them stood the male's breasts reconstruction in the case of pseudo-gynecomastia. Read More

    Association of Dermatoses with Duration and Quantum of Alcohol Intake: A Comparative Cross-sectional Study.
    Indian J Dermatol 2017 Mar-Apr;62(2):184-190
    Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
    Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

    Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

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