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    The Characteristics and Short-Term Surgical Outcomes of Adolescent Gynecomastia.
    Aesthetic Plast Surg 2017 Apr 27. Epub 2017 Apr 27.
    Department of Surgery, Damsoyu Hospital, 213 Bongeunsa-ro, Gangnam-gu, Seoul, Korea.
    Background: Most adolescent gynecomastia is resolved spontaneously in 3 years. But, persistent gynecomastia could have a negative influence on psychoemotional development on adolescence. The purpose of this study is to report the characteristics of adolescent gynecomastia patients who received the surgeries, and discuss the short-term surgical outcomes. Read More

    Nihon Hinyokika Gakkai Zasshi 2016 ;107(2):121-125
    Department of Pathology, Tohoku University Graduate School of Medicine.
    A 64-year-old man had complained of a left scrotal mass and gynecomastia since June 2012. A left testicular tumor was suspected and the patient was referred to our department in December 2013. He presented with bilateral gynecomastia and a painless left scrotal mass that was firm, smooth surfaced, and the size of large hen's egg. Read More

    Multiple symmetric lipomatosis and gynecomastia: A case report and relative literature review.
    J Clin Lipidol 2017 Mar 30. Epub 2017 Mar 30.
    Department of Endocrinology, The Third Hospital of Hebei Medical University, ShiJiazhuang, Hebei Province, China.
    Multiple symmetric lipomatosis is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk, and limbs. Here, we reported an extremely rare case of multiple symmetric lipomatosis in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. Read More

    Polyembryoma of the testis: a report of two cases dominant within mixed germ cell tumors and review of gonadal polyembryomas.
    Mod Pathol 2017 Apr 21. Epub 2017 Apr 21.
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Two testicular mixed germ cell tumors, from men of 21 and 41 years, in which polyembryoma predominated are described. A literature review uncovered an additional five testicular and nine ovarian cases. One tumor occurred in a 60-year-old man, but all others occurred within the typical age range of gonadal germ cell tumors. Read More

    Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of a Rare Lesion.
    Case Rep Oncol Med 2017 21;2017:5172072. Epub 2017 Mar 21.
    Department of General Surgery, Larkin Community Hospital, South Miami, FL, USA.
    There has been an increasing use of hormonal therapy among male-to-female (MtF) transgender individuals. This long-term hormone replacement therapy (HRT) renders MtF individuals a unique patient subgroup in terms of breast cancer risk. This case describes a MtF transgender who presented with a breast lesion concerning for malignancy following hormonal replacement therapy. Read More

    Ovotestis in Adolescence: Two Case Reports.
    Urology 2017 Apr 13. Epub 2017 Apr 13.
    Children's Hospital of Philadelphia, Division of Urology, Philadelphia, PA. Electronic address:
    We present two patients found to have ovotesticular disorder of sexual differentiation (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: one with concern for testicular rupture after a straddle injury; the other with gynecomastia. Further work-up, including imaging and lab tests, was performed before surgical exploration. Read More

    Paul of Aegina (ca 625-690 ad), Reconstructing Male Gynecomastia.
    Surg Innov 2017 Mar 1:1553350617697185. Epub 2017 Mar 1.
    1 University of Thessaly, Larissa, Greece.
    Paul of Aegina thrived with his innovative operations, practically creating a kind of a new surgical school. He had deeply believed in human's body perfection introducing a series of cosmetic operations. Among them stood the male's breasts reconstruction in the case of pseudo-gynecomastia. Read More

    Association of Dermatoses with Duration and Quantum of Alcohol Intake: A Comparative Cross-sectional Study.
    Indian J Dermatol 2017 Mar-Apr;62(2):184-190
    Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
    Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

    Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

    Complications and Outcomes After Gynecomastia Surgery: Analysis of 204 Pediatric and 1583 Adult Cases from a National Multi-center Database.
    Aesthetic Plast Surg 2017 Mar 24. Epub 2017 Mar 24.
    Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, 6560 Fannin Street, Scurlock Tower, Suite 2200, Houston, TX, 77030, USA.
    Background: Gynecomastia is a common disease that is prevalent across all age groups of boys and men. Although benign in nature, it can lead to psychological and social distress, prompting affected patients to seek medical attention. Management strategies include observation and drug therapy, yet surgical procedures remain the hallmark of treatment. Read More

    Surgical Masculinization of the Breast: Clinical Classification and Surgical Procedures.
    Aesthetic Plast Surg 2017 Mar 24. Epub 2017 Mar 24.
    Division of Plastic Surgery, Jalisco Institute of Reconstructive Surgery "Dr. José Guerrerosantos", Guadalajara, Jalisco, Mexico.
    Introduction: Aesthetic breast area improvements for gynecomastia and gender dysphoria patients who seek a more masculine appearance have increased recently. We present our clinical experience in breast masculinization and a classification for these patients.

    Methods And Materials: From July 2003 to May 2014, 68 patients seeking a more masculine thorax underwent surgery. Read More

    Aesthetic Breast Surgery and Concomitant Procedures: Incidence and Risk Factors for Major Complications in 73,608 Cases.
    Aesthet Surg J 2017 May;37(5):515-527
    Drs Gupta and Higdon are Assistant Professors, Dr Winocour is a Fellow, and Dr Bamba is a Research Resident, Department of Plastic Surgery, Vanderbilt University, Nashville, TN. Dr Yeslev is an Attending, Southeast Permanente Medical Group, Atlanta, GA. Dr Rodriguez-Feo is a Resident, Department of Plastic Surgery, University of Washington, Seattle, WA. Dr Grotting is a Clinical Professor, Division of Plastic Surgery, University of Alabama, Birmingham, AL; and CME/MOC Section Editor for Aesthetic Surgery Journal.
    Background: Major complications following aesthetic breast surgery are uncommon and thus assessment of risk factors is challenging.

    Objectives: To determine the incidence and risk factors of major complications following aesthetic breast surgery and concomitant procedures.

    Methods: A prospective cohort of patients who enrolled into the CosmetAssure (Birmingham, AL) insurance program and underwent aesthetic breast surgery between 2008 and 2013 was identified. Read More

    Long-Term Follow-up of Recurrence and Patient Satisfaction After Surgical Treatment of Gynecomastia.
    Aesthetic Plast Surg 2017 Mar 9. Epub 2017 Mar 9.
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Faculty of Medicine, Hugstetter Strasse 55, 79106, Freiburg, Germany.
    Background: "Gynecomastia" is an enlargement of the male breast. Our study aims to assess patient satisfaction as well as evaluate differences in recurrence rates in lipomatous and glandular gynecomastia 10-19 years postoperatively.

    Methods: Forty-one gynecomastia patients undergoing surgical treatment from 1997 to 2005 were invited for a follow-up examination 10-19 years postoperatively. Read More

    Gynecomastia in Infants, Children, and Adolescents.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Mar 1. Epub 2017 Mar 1.
    Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta, Canada.
    Background: Gynecomastia may occur physiologically in the neonatal period, during puberty, and in old age. It may also develop in association with various pathologic states. The challenge for the physician is to distinguish physiological gynecomastia from those with an underlying pathology. Read More

    Effects of Anabolic Androgenic Steroids on the Reproductive System of Athletes and Recreational Users: A Systematic Review and Meta-Analysis.
    Sports Med 2017 Mar 4. Epub 2017 Mar 4.
    Department of Endocrinology, Medical School, University of Ioannina, Ioannina, Greece.
    Background: Anabolic androgenic steroids (AAS) are testosterone derivatives used by athletes and recreational users to improve athletic performance and/or enhance appearance. Anabolic androgenic steroids use may have serious and potentially irreversible adverse effects on different organs and systems, including the reproductive system.

    Objective: This systematic review and meta-analysis aimed to critically assess the impact of AAS use on the reproductive system of athletes and recreational users. Read More

    Reduction of the Areolar Diameter After Ultrasound-Assisted Liposuction for Gynecomastia.
    Ann Plast Surg 2017 Mar 1. Epub 2017 Mar 1.
    From the Plastic, Reconstructive, and Aesthetic Surgery Department, Istanbul Medipol University, Turkey.
    Background: One of the clinical aspects characterizing gynecomastia is the enlargement of the nipple-areolar complex (NAC) due to hypertrophic breast glands, and the excessive fatty tissue underneath.

    Objective: The purpose of this study was to quantify the reduction of the areolar diameter after ultrasound-assisted liposuction (UAL) of the male breast.

    Methods: The horizontal diameters of the NACs of 30 men who underwent UAL were measured before surgery, 1 month after surgery and 6 months after surgery in a standard fashion. Read More

    Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System.
    Plast Reconstr Surg 2017 Mar;139(3):638e-648e
    Ottawa and Hamilton, Ontario, Canada From the Department of Medicine, Faculty of Medicine, University of Ottawa; and the Division of Plastic Surgery and the Surgical Outcomes Research Center, Department of Surgery, and the Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University.
    Background: Gynecomastia is a common deformity of the male breast, where certain cases warrant surgical management. There are several surgical options, which vary depending on the breast characteristics. To guide surgical management, several classification systems for gynecomastia have been proposed. Read More

    Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia.
    Clin Epidemiol 2017 10;9:83-91. Epub 2017 Feb 10.
    Boston Collaborative Drug Surveillance Program, Boston University School of Public Health, Lexington.
    Background: Clinical trial results suggest that 5-alpha reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH) may increase the risk of gynecomastia and male breast cancer, but epidemiological studies have been limited.

    Patients And Methods: We conducted a cohort study with nested case-control analyses using the UK Clinical Practice Research Datalink. We identified men diagnosed with BPH who were free from Klinefelter syndrome, prostate, genital or urinary cancer, prostatectomy or orchiectomy, or evidence of gynecomastia or breast cancer. Read More

    Adolescent gynecomastia is associated with a high incidence of obesity, dysglycemia, and family background of diabetes mellitus.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):160-164
    Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.
    Background: Gynecomastia during adolescence is common though etiology is not clear. We studied the clinical and hormonal profile of adolescent patients with gynecomastia.

    Methodology: Patients who had onset of breast development between age 10 and 20 years were included in this study. Read More

    Postero-Inferior Pedicle Surgical Technique for the Treatment of Grade III Gynecomastia.
    Aesthetic Plast Surg 2017 Feb 15. Epub 2017 Feb 15.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Hospital Sud, University of Rennes 1, 16 Boulevard de Bulgarie, 35200, Rennes, France.
    Introduction: Surgical treatment of Grade III gynecomastia generally utilizes mastectomy techniques and free transplantation of the nipple-areola complex. Moreover, with rising obesity rates and the development of bariatric surgery, an increasing demand for correctional surgery for pseudogynecomastia has been observed, which is comparable to Grade III gynecomastia in terms of its surgical management. Here, we describe an innovative technique to deal with these new demands: fascio-cutaneous flap by postero-inferior pedicle. Read More

    Gynaecomastia in 786 adult men: clinical and biochemical findings.
    Eur J Endocrinol 2017 May 8;176(5):555-566. Epub 2017 Feb 8.
    Department of Growth and ReproductionRigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Objective: Gynaecomastia is a benign proliferation of glandular tissue of the breast; however, it is an important clinical observation because it can be the first symptom of an underlying disease. Some controversy exists concerning the clinical importance of an in-depth investigation of men who develop gynaecomastia. We hypothesise that a thorough work-up is required in adult men with gynaecomastia. Read More

    Effects of laser-assisted lipolysis on nipple-areola complex.
    J Cosmet Laser Ther 2017 Feb 2:1-4. Epub 2017 Feb 2.
    a Department of Plastic , Reconstructive and Aesthetic Surgery, Bezmialem Medical School, Bezmialem Vakif University , Istanbul , Turkey.
    Background: Gynecomastia, as a most common benign condition, represents itself as the enlargement of the male breast and also nipple-areola complex as the severity of the condition increases. With this study, we aimed to clarify the effects of 980-nm diode laser on nipple-areola complex (NAC).

    Objectives: Although numerous open techniques have been described to correct gynecomastia, nowadays trends have shifted to minimally invasive techniques such as laser-assisted lipolysis (LAL). Read More

    Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer.
    N Engl J Med 2017 02;376(5):417-428
    From Massachusetts General Hospital and Harvard Medical School, Boston (W.U.S., N.M.H., A.L.Z.); NRG Oncology Statistics and Data Management Center (W.S., J.J.D., S.L.P.) and Einstein Medical Center (K.L.Z.), Philadelphia; Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON (H.R.L., P.P.M., M.P.P.), Hospital Notre-Dame du Centre Hospitalier de l'Université de Montréal (J.-P.B.) and McGill University Health Centre (L.S.), Montreal, and Tom Baker Cancer Centre, Calgary, AB (A.G.B.) - all in Canada; Indiana University, Indianapolis (D.J.G.); Tulane University, New Orleans (O.S.); Mayo Clinic, Rochester, MN (T.M.P.); Medical College of Wisconsin, Milwaukee (C.A.F.L.); University of Michigan, Ann Arbor (F.Y.F.); University of Vermont Medical Center, Burlington (R.D.L.); Radiation Oncology Center, Sacramento (S.A.R.), and Cedars-Sinai Medical Center, Los Angeles (H.M.S.) - both in California; Wayne Radiation Oncology, Goldsboro, NC (K.J.K.); and the University of Chicago, Chicago (J.J.D.).
    Background: Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown.

    Methods: In a double-blind, placebo-controlled trial conducted from 1998 through 2003, we assigned 760 eligible patients who had undergone prostatectomy with a lymphadenectomy and had disease, as assessed on pathological testing, with a tumor stage of T2 (confined to the prostate but with a positive surgical margin) or T3 (with histologic extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0. Read More

    The Impact Exerted on Clinical Outcomes of Patients With Chronic Heart Failure by Aldosterone Receptor Antagonists: A Meta-Analysis of Randomized Controlled Trials.
    J Clin Med Res 2017 Feb 31;9(2):130-142. Epub 2016 Dec 31.
    Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale" IRCCS, Napoli, Italy.
    Background: Aldosterone receptor antagonists (ARAs) have been associated with improved clinical outcomes in patients with heart failure with reduced left ventricular ejection fraction (HFREF), but not in those with heart failure with preserved left ventricular ejection fraction (HFpEF). With the aim to study this topic more deeply, we carried out a meta-analysis of selective and non-selective ARAs in HFREF and HFpEF.

    Methods: We searched PubMed and Scopus databases. Read More

    A 33-Year-Old Man with Gynaecomastia and Galactorrhea as the First Symptoms of Graves Hyperthyroidism.
    Case Rep Endocrinol 2016 1;2016:1946824. Epub 2016 Dec 1.
    Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Graves' hyperthyroidism has a various number of well-recognized manifestations. Galactorrhea is a rare manifestation in this disease. We describe a 33-year-old man who presented with the symptoms of hyperthyroidism, gynaecomastia, and galactorrhea for 2 months. Read More

    No-Drain Single Incision Liposuction Pull-Through Technique for Gynecomastia.
    Aesthetic Plast Surg 2017 Apr 28;41(2):298-303. Epub 2016 Dec 28.
    Division of Plastic Surgery, Department of Surgery, Cairo University Hospitals, Cairo, Egypt.
    Background: Several different methods have been proposed for treatment of gynecomastia, depending on the amount of breast enlargement and skin redundancy. The liposuction pull-through technique has been proposed as an efficacious treatment for many gynecomastia cases. This work aims to study the outcome of this technique when applied as an outpatient procedure, without the use of drains and through a single incision. Read More

    Effect of investigation intensity and treatment differences on prostate cancer survivor's physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study.
    BMJ Open 2016 Dec 19;6(12):e012952. Epub 2016 Dec 19.
    Institute of Health & Society, Newcastle University, Newcastle-upon-Tyne, UK.
    Aim: To investigate effects on men's health and well-being of higher prostate cancer (PCa) investigation and treatment levels in similar populations.

    Participants: PCa survivors in Ireland where the Republic of Ireland (RoI) has a 50% higher PCa incidence than Northern Ireland (NI).

    Method: A cross-sectional postal questionnaire was sent to PCa survivors 2-18 years post-treatment, seeking information about current physical effects of treatment, health-related quality of life (HRQoL; EORTC QLQ-C30; EQ-5D-5L) and psychological well-being (21 question version of the Depression, Anxiety and Stress Scale, DASS-21). Read More

    Aldosterone receptor antagonists decrease mortality and cardiovascular hospitalizations in chronic heart failure (CHF) with reduced left ventricular ejection fraction(LVEF), but not in CHF with preserved LVEF. A meta-analysis of randomized controlled trials.
    Minerva Cardioangiol 2016 Dec 13. Epub 2016 Dec 13.
    Geriatric Department, Casa di Cura "S.Maria del Pozzo", Somma Vesuviana, Naples, Italy.
    Introduction: Aldosterone receptor antagonists (ARAs) were introduced in the treatment of chronic heart failure (CHF), as a result of the demonstration of their protective effect on the failing heart. However, important questions remain unanswered regarding the clinical efficacy of the ARAs on the clinical and echocardiographic phenotype of heart failure, called heart failure with preserved left ventricular ejection fraction( HFpEF).

    Evidence Acquisition: The aim of the present meta-analysis was to verify the impact of the ARAs on some hard endpoints, such as all - cause death and hospitalizations from cardiovascular cause, making a comparative evaluation of these outcomes in CHF patients with reduced left ventricular ejection fraction (HFREF) and in those with HFpEF, respectively. Read More

    Atypical Leydig Cell Tumor in Children: Report of 2 Cases.
    Pediatrics 2016 Nov;138(5)
    Departments of Pediatrics, and.
    Leydig cell tumors (LCTs) are rare cord-stromal tumors that may occur in testis or ovaries and may produce androgens or estrogens. The majority has been found in men between the ages of 20 and 60 years. Adults with androgen-secreting LCTs are usually asymptomatic; feminizing syndromes may result from the production of estradiol or the peripheral aromatization of testosterone. Read More

    Surgical management of gynecomastia: experience of a general surgery center.
    G Chir 2016 Jul-Aug;37(4):150-154
    Aim: Gynecomastia is a common finding in male population of all ages. The aim of our study was to present our experience and goals in surgical treatment of gynecomastia.

    Patients And Methods: Clinical records of patients affected by gynecomastia referred to our Department of Surgery between September 2008 and January 2015 were analyzed. Read More

    Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia.
    Breast Care (Basel) 2016 Oct 13;11(5):333-337. Epub 2016 Oct 13.
    Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Ihsan Dogramaci Children's Hospital, Ankara, Turkey, Ankara, Turkey.
    Background: Since vitamin D has an inhibitory function on ductal morphogenesis of the pubertal mammary gland, it may have a role in the development of gynecomastia. The aim of this study was to determine the effect of vitamin D deficiency on the development of pubertal gynecomastia.

    Methods: Serum 25-hydroxyvitamin D (25D) levels in 50 adolescents with pubertal gynecomastia and 54 healthy controls between the ages of 11 and 17 years were compared. Read More

    Mineralocorticoid receptor antagonists for heart failure: systematic review and meta-analysis.
    BMC Cardiovasc Disord 2016 Dec 1;16(1):246. Epub 2016 Dec 1.
    Department of Medicine, Western University, 339 Windermere Road, London, ON, N6A 5A5, Canada.
    Background: Mineralocorticoid receptor antagonists (MRAs) have been associated with improved patient outcomes in patients with heart failure with reduced ejection fraction (HFrEF) but not preserved ejection fraction (HFpEF). We conducted a systematic review and meta-analysis of selective and nonselective MRAs in HFrEF and HFpEF.

    Methods: We searched Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. Read More

    Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa.
    AIDS Res Ther 2016 16;13:40. Epub 2016 Nov 16.
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
    Background: Gynaecomastia is associated with exposure to antiretroviral therapy (ART), in particular efavirenz. There is limited data on clinical characteristics of patients with ART-associated gynaecomastia in resource-limited settings and little guidance on the optimal management of this adverse drug reaction (ADR). We describe the clinical characteristics, management and outcomes of gynaecomastia cases reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa. Read More

    Who Gets Severe Gynecomastia Among HIV-infected Children in the United Kingdom and Ireland?
    Pediatr Infect Dis J 2017 Mar;36(3):307-310
    From the *MRC Clinical Trials Unit at UCL, University College London, London, United Kingdom; and †St. George's Healthcare NHS Trust, London, United Kingdom.
    There are few data on gynecomastia in HIV-infected children. Within the UK/Ireland's national cohort, 56 of 1873 (3%) HIV-infected children had gynecomastia, of which 10 (0.5%) were severe. Read More

    J Clin Res Pediatr Endocrinol 2016 Nov 22. Epub 2016 Nov 22.
    Peutz-Jeghers Syndrome (PJS) is inherited as an autosomal dominant trait which is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous pigmentation, and an increased risk of neoplasm. Large Cell Calcifying Sertoli Cell Tumor (LCCSCT) is a kind of sex cord-stromal tumor, often bilateral and multifocal, accounting for 0.4 -1. Read More

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