6,564 results match your criteria Gynecologie Obstetrique & Fertilite[Journal]


Evaluation of ligament laxity during pregnancy.

J Gynecol Obstet Hum Reprod 2019 Feb 19. Epub 2019 Feb 19.

Institut Pprime. Axe RoBioSS, CNRS UPR 3346 Université de Poitiers. Téléport 2, boulevard Marie et Pierre Curie BP 30179, 86962, Futuroscope, France. Electronic address:

Objective: Pregnancy-related changes in ligament laxity have been shown to be associated with various disorders such as back pain or pelvic floor disorders. The purpose of this study was to assess laxity changes during pregnancy by confronting different methods in order to suggest a simple clinical tool helping to prevent the aforementioned problems.

Design: 17 pregnant women were evaluated at the first, second and third trimesters as cases and 16 non-pregnant women participated as controls. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.02.009DOI Listing
February 2019

[Congenital heart block revealing a maternal systemic disease : pathophysiology and therapeutic approaches].

Rev Med Liege 2019 Feb;74(2):95-99

Service de Gynécologie-Obstétrique, CHU Liège, Belgique.

Immunologic congenital atrioventricular block is due to the presence of anti-SSA and anti-SSB antibodies in maternal blood. This pathology is often diagnosed when the status is irreversible and is consequently associated with a high morbi-mortality. Close monitoring for high risk pregnancies can help to diagnose first and second degrees heart block and treatments can be offered when the block is still reversible. Read More

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February 2019

[Surgery for advanced stage ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Feb 18. Epub 2019 Feb 18.

IMRB, U955 Inserm, service de gynécologie obstétrique et médecine de la reproduction, centre hospitalier intercommunal de Créteil, institut Mondor de recherche biomédicale, 94000 Créteil, France. Electronic address:

Debulking surgery is the key step of advanced stage ovarian cancer treatment with chemotherapy. The quality of surgical resection is the main prognosis factor, thus a complete resection must be achieved (grade A) in an expert center (grade B). Surgery for stage IV is possible and has a benefit in case of complete peritoneal resection (LoE3). Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.003DOI Listing
February 2019

Pelvic floor muscle activation in stress urinary incontinent women: Impact of a distraction task.

Neurourol Urodyn 2019 Feb 19. Epub 2019 Feb 19.

GRC-UPMC 01, GREEN (Group of Clinical Research in Neuro-Urology, University Pierre and Marie Curie), Paris, France.

Aims: Our purpose was to explore the involvement of cognition in voluntary and involuntary pelvic floor muscle (PFM) contraction in stress urinary incontinent women.

Methods: PFM contraction monitored by surface electromyography (EMG) was measured without a mental distraction task (DT), and with a DT called "paced auditory serial additional test" (PASAT). Forty stress incontinent women performed voluntary contractions of the external anal sphincter (EAS), and reflex EAS contractions induced by means of coughing were studied using the external intercostal muscle (EIC) EMG pattern. Read More

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http://dx.doi.org/10.1002/nau.23936DOI Listing
February 2019

Prenatal diagnosis of Fragile X syndrome: small meiotic recombination events at the FMR1 locus.

Prenat Diagn 2019 Feb 18. Epub 2019 Feb 18.

Service de Génétique, CHRU de Tours, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Objective: Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, is caused by an expansion over 200 CGG repeats (full mutation) in the FMR1 gene. Intergenerational instability of an expanded FMR1 allele is linked to the carrier's gender (female), the CGG repeat size and the number of AGG interspersions within the CGG repeat, making genetic counseling a complex task. The objective of our work was to emphasize the importance of combining haplotype analysis with FMR1 linked markers and CGG repeat sizing for prenatal diagnosis (PND) of FXS. Read More

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http://dx.doi.org/10.1002/pd.5439DOI Listing
February 2019

Prenatal imaging of genital defects: clinical spectrum and predictive factors for severe forms.

BJU Int 2019 Feb 18. Epub 2019 Feb 18.

Unité de Chirurgie Viscérale et Urologique Pédiatrique, Hôpital Lapeyronie - CHU Montpellier, France, et Université de Montpellier, France.

Objectives: 1-To report the clinical spectrum of genital defects diagnosed before birth, 2- to identify predictive factors for severe phenotypes at birth 3- to determine the rate of associated malformations.

Methods: A retrospective study (2008-2017) of 4580 fetuses identified prenatally with abnormalities evaluated by our Reference Center for Fetal Medicine included cases with fetal sonographic finding of abnormal genitalia or uncertainty of fetal sex determination. Familial, prenatal and postnatal data were collected through a standardized questionnaire. Read More

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http://dx.doi.org/10.1111/bju.14714DOI Listing
February 2019

[How I do… a laparoscopic orthotopic ovarian cortex transplantation].

Gynecol Obstet Fertil Senol 2019 Feb 14. Epub 2019 Feb 14.

Sorbonne université, 75005 Paris, France; Service d'hématologie, unité AJA, préservation de la fertilité, hôpital Saint-Louis, 75010 Paris, France.

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http://dx.doi.org/10.1016/j.gofs.2019.01.007DOI Listing
February 2019

Uterus transplantation and altruistic surrogacy: Are they complementary or alternative options?-A statement from the CNGOF French Uterus Transplantation Committee.

J Gynecol Obstet Hum Reprod 2019 Feb 13. Epub 2019 Feb 13.

Service de gynécologie, CHU de Rennes, Hôpital sud, 16 bd de Bulgarie, 35000 Rennes, France.

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http://dx.doi.org/10.1016/j.jogoh.2019.02.001DOI Listing
February 2019

[Impact of the quality of ultrasound scan performed in gynecological emergencies in the diagnosis of ectopic pregnancy].

Gynecol Obstet Fertil Senol 2019 Feb 12. Epub 2019 Feb 12.

Service de Gynécologie Obstétrique, C.H.I. de Poissy Saint-Germain, Poissy, France; Unité de recherche EA 7285 - Risques cliniques et sécurité en santé des femmes et en santé périnatale (RISCQ), Université de Versailles-Saint-Quentin (UVSQ), Saint-Quentin-en-Yvelines, France.

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http://dx.doi.org/10.1016/j.gofs.2019.02.003DOI Listing
February 2019
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Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE).

BMC Pregnancy Childbirth 2019 Feb 12;19(1):67. Epub 2019 Feb 12.

Université Paris Diderot, Site Villemin, 10 avenue de Verdun, 75010, Paris, France.

Background: Although antenatal betamethasone is recommended worldwide for women at risk of preterm delivery, concerns persist regarding the long-term effects associated with this treatment. Indeed, adverse events, mainly dose-related, have been reported. The current recommended dose of antenatal betamethasone directly derives from sheep experiments performed in the late 60's and has not been challenged in 45 years. Read More

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http://dx.doi.org/10.1186/s12884-019-2206-xDOI Listing
February 2019

[Pathophysiology, diagnosis and management of occiput posterior presentation during labor.]

Gynecol Obstet Fertil Senol 2019 Feb 9. Epub 2019 Feb 9.

Service de gynécologie obstétrique, Hôpital Nord, Gynépôle, Assistance Publique des Hôpitaux de Marseille, Chemin des Bourelly, 13015 Marseille; EA 3279, Public Health, Chronic Diseases and Quality of Life, Research Unit, Aix-Marseille University, 13284, Marseille, France.

Persistant occiput posterior (OP) positions are the commonest malpresentations of the fetal head during labor and their diagnosis remains challenging. They are associated to prolonged second stage of labor, prolonged expulsive efforts, labor augmentation, cesarean sections and instrumental deliveries. On the maternal side, severe perineal tears, post-partum hemorrhage or chorioamnionitis are more frequent. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.02.002DOI Listing
February 2019
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[Assisted reproductive technologies in HIV patients: which results and which strategy in France in 2019].

Gynecol Obstet Fertil Senol 2019 Feb 9. Epub 2019 Feb 9.

Unité de Médecine de la Reproduction, Service de Gynécologie-Obstétrique, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard 75018 Paris, France. Electronic address:

With the use of antiretroviral therapy, HIV transmission from mother to fetus and between sexual partners has been significantly reduced, successively allowing pregnancy, then assisted reproductive technologies, and targeted unprotected sex among couples living with HIV. Since first french Morlat report in 2013, natural procreation is now possible under certain conditions for these couples living with HIV and the use of assisted reproductive technologies is increasingly limited to the treatment of infertility. While the results of intrauterine insemination seem satisfactory for serodiscordant couples living with HIV, in vitro fertilization results appear to be unfavorable when the woman is infected with HIV. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.02.001DOI Listing
February 2019

Reduced α-2,6 sialylation regulates cell migration in endometriosis.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Département 'Développement, Reproduction et Cancer', Institut Cochin, INSERM U1016 (Professeur Batteux), Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, Paris, France.

Study Question: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties?

Summary Answer: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration.

What Is Known Already: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate. Aberrant sialylation has been reported in various malignancies and it has been linked to tumour invasion and metastasis. Read More

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http://dx.doi.org/10.1093/humrep/dey391DOI Listing
February 2019
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[Comparison of birth weights of children born after slow frozen embryo replacement versus fresh embryo transfer].

Gynecol Obstet Fertil Senol 2019 Feb 8. Epub 2019 Feb 8.

Département de biologie de la reproduction, CHU de Montpellier, 34000 Montpellier, France; Inserm, U1203, institut de médecine régénératrice et de biothérapie, CHU de Montpellier, 34000 Montpellier, France.

Objective: It is already known that children born after slow frozen embryo replacement have a significantly higher birth weight compared to children born after fresh embryo transfer. Similar data have been reported related to frozen embryo transfer using an open vitrification system. However, few data relative to birth weight using a complete embryo closed vitrification system has been reported. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.011DOI Listing
February 2019
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High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia.

Redox Biol 2019 Jan 26;22:101126. Epub 2019 Jan 26.

Inserm U-1048, Université de Toulouse, France. Electronic address:

Decreased nitric oxide (NO) bioavailability plays a critical role in the pathophysiology of preeclampsia (PE). Recent evidence indicates that S-glutathionylation may occur on the endothelial nitric oxide synthase (eNOS), leading to eNOS uncoupling, characterized by a decreased NO production and an increased generation of superoxide anion (O). We hypothesized that eNOS glutathionylation may occur in PE placentas and participate in eNOS dysfunction. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370867PMC
January 2019
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Can early βhCG change and baseline progesterone level predict treatment outcome in patients receiving single dose Methotrexate protocol for tubal ectopic pregnancy?

Arch Gynecol Obstet 2019 Feb 8. Epub 2019 Feb 8.

CHU Toulouse, Pôle de Gynécologie Obstétrique, Department of Obstetrics and Gynecology, Hôpital Paule de Viguier, 31059, Toulouse, France.

Introduction: We aimed to assess the prognostic significance of early βhCG change and baseline progesterone level on treatment outcome among women receiving single dose Methotrexate protocol for tubal ectopic pregnancy (EP).

Material And Methods: Retrospective study involving all consecutive patients diagnosed with EP and receiving Methotrexate therapy form January 2015 to December 2016. Patients were stratified into 2 groups according to treatment outcome: success group (n = 66) involved women who displayed complete resolution of serum βhCG levels following a single course of Methotrexate; failure group (n = 55) included patients who required repeated Methotrexate administration and/or surgical management. Read More

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http://dx.doi.org/10.1007/s00404-019-05068-1DOI Listing
February 2019
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[Management of Epithelial Ovarian Cancer : French joint recommendations of FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY and endorsed by INCa. Introduction].

Gynecol Obstet Fertil Senol 2019 Feb 4. Epub 2019 Feb 4.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, Assistance publique des hôpitaux de Paris (AP-HP), 4, rue de la Chine, 75020 Paris, France; UMRS-938, faculté de médecine UPMC, centre cancer associé à la grossesse (CALG), institut universitaire de cancérologie (IUC), Sorbonne université, 75000 Paris, France. Electronic address:

Ovarian cancer had a poor prognosis that could be heterogeneous according specialized center or not and according elderly in comparison with their younger counterpart. National recommendations are required to propose homogeneous practice and increase overall ovarian cancer prognosis. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.006DOI Listing
February 2019
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[Diagnostic and prognostic value of tumor markers, scores (clinical and biological) algorithms, in front of an ovarian mass suspected of an epithelial ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Feb 4. Epub 2019 Feb 4.

Département de gynécologie, centre hospitalier universitaire de Tours, 2, boulevard Tonnellé, 37044 Tours, France; Inserm U1069, université François-Rabelais, 37044 Tours, France. Electronic address:

Objectives: To evaluate the diagnostic value of serum/urinary biomarkers and the operability diagnosis strategy to make management recommendations.

Methods: Bibliographical search in French and English languages by consultation of Pubmed, Cochrane and Embase databases.

Results: For the diagnosis of a suspicious adnexal mass on imaging: Serum CA125 antigen is recommended (grade A). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.013DOI Listing
February 2019
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Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta.

Clin Epigenetics 2019 Feb 7;11(1):20. Epub 2019 Feb 7.

GIG-EA 7404, Université de Versailles-St Quentin, Université Paris-Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, 2 avenue de la Source de la Bièvre, F-78180, Montigny-le-Bretonneux, France.

Background: It is well established that obesity is associated with dysregulation of the ratio between the two major adipokines leptin and adiponectin. Furthermore, it was recently reported that maternal obesity has a significant impact on placental development. Leptin and adiponectin are present at the fetal-maternal interface and are involved in the development of a functional placenta. Read More

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http://dx.doi.org/10.1186/s13148-019-0612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367801PMC
February 2019

Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed charge syndrome individuals.

Prenat Diagn 2019 Feb 4. Epub 2019 Feb 4.

Service de Radiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), France.

"CHARGE syndrome" (CS) is a multifaceted syndrome associated with a poor prognosis. The prenatal diagnosis remains challenging especially as the fetal anomalies that may evoke suspicion of CS are not comprehensively described.

Objective: This study aims to identify the anomalies in MRI with suspected CHARGE syndrome and to propose a possible standardization in the image-based prenatal diagnosis of CS. Read More

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http://dx.doi.org/10.1002/pd.5429DOI Listing
February 2019

Twin vaginal delivery: To maintain skill - simulation is required.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 24;234:195-199. Epub 2019 Jan 24.

Hôpital Bichat, Maternité Aline de Crepy, APHP, 75018, Paris, France; Université Paris Diderot, Paris 7, Paris, France; Ilumens Paris Diderot, Centre de simulation, Paris, France; DHU Risk and Pregnancy (Paris V and Paris VII University), France. Electronic address:

Background: Although most societies of obstetrics advocate vaginal delivery of twins, there has been a steady rise in the rate of twin cesarean sections. We risk perhaps losing in a single generation our obstetrical learning and skills because of medicolegal and emotionally charged issues.

Methods: We have therefore designed a realistic as possible simulation model of second twin delivery and tested it on residents in obstetrics. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.038DOI Listing
March 2019
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[Epithelial ovarian cancer and fertility preservation: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Jan 28. Epub 2019 Jan 28.

Centre de Recherche Saint Antoine UMRS_938, service de gynécologie, obstétrique, médecine de la reproduction, institut universitaire de cancérologie, Groupe Hospitalier AP-HP, 6 site Tenon, Sorbonne université, Plateforme de préservation de la fertilité, 4, rue de la Chine, 75020 Paris, France. Electronic address:

Objectives: To study the methods and strategies of fertility preservation in young women with stage I epithelial ovarian cancer (EOC), in order to provide recommendations for clinical practice.

Methods: The PubMed database was searched for english and french language articles, between 2005 and 2001, according to predefined search equations.

Results: Young patients with stage IA EOC willing to conceive should be informed that conservative treatment (contralateral ovary and salpinx, uterus) is possible (GradeC), associated with a 6 % to 13 % recurrence risk (GradeC) on the remaining ovary. Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.004DOI Listing
January 2019
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[Part II drafted from the short text of the French guidelines entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY and endorsed by INCa. (Systemic and intraperitoneal treatment, elderly, fertility preservation, follow-up)].

Gynecol Obstet Fertil Senol 2019 Jan 28. Epub 2019 Jan 28.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Institut universitaire de cancérologie, UMRS-938, Sorbonne université, 75000 Paris, France.

Adjuvant chemotherapy with carboplatin and paclitaxel is recommended for all high-grade ovarian or Fallopian tube cancers, stage FIGO I-IIA (grade A). After a complete first surgery, it is recommended to deliver 6 cycles of intravenous (grade A) or to propose intraperitoneal (grade B) chemotherapy, to be discussed with patient, according to the benefit/risk ratio. After a complete interval surgery for a FIGO III stage, the hyperthermic intra peritoneal chemotherapy (HIPEC) can be proposed in the same conditions of the OV-HIPEC trial (grade B). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.011DOI Listing
January 2019
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[French joint recommendations Management for Epithelial Ovarian Cancer of FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY endorsed by INCa. Strengths and weaknesses].

Gynecol Obstet Fertil Senol 2019 Jan 25. Epub 2019 Jan 25.

Service de gynécologie-obstétrique et médecine de la reproduction, centre CALG (cancer associé à la grossesse), UMRS-938, faculté de médecine UPMC, Sorbonne université, institut universitaire de cancérologie (IUC), hôpital Tenon, Assistance publique des Hôpitaux de Paris (AP-HP), 75000 Paris, France. Electronic address:

A task force was organized to write French national recommendations for management of ovarian cancer. We proposed to present strengths and weaknesses of this work. Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.014DOI Listing
January 2019

A novel concept for female infertility exploration: the Fertiliscan©, a dedicated all-in-one 3D ultrasound exploration.

J Gynecol Obstet Hum Reprod 2019 Jan 25. Epub 2019 Jan 25.

Service de gynécologie-obstétrique et reproduction, Centre Hospitalier Intercommunal de Créteil, Université Paris-Est Val de Marne, Créteil, France. Electronic address:

The investigation of the probable cause of infertility is mandatory to propose an accurate therapeutic option to the infertile couple i.e. good chance of pregnancy. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.01.008DOI Listing
January 2019

[Diagnostic value of imaging (ultrasonography, doppler, CT, MR, PET-CT) for the diagnosis of a suspicious ovarian mass and staging of ovarian, tubal or primary peritoneal cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Service de radiologie, université Paris Descartes Sorbonne Paris Cité, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, Inserm UMR-S970, Cardiovascular Research Center - PARCC, 56, rue Leblanc, 75015 Paris, France.

Transvaginal ultrasound is the first-line examination allowing characterizing 80 to 90% of adnexal masses (LP1). If performed by an expert, a subjective analysis is optimal. If performed by a non-expert, combining the use of Simple Rules with subjective analysis can achieve the diagnostic performance of an expert (LP1). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.012DOI Listing
January 2019
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[Surgery in early-stage ovarian cancer: Article drafted from the French Guidelines in oncology entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa].

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Clinique de gynécologie, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, 1, rue Eugène-Avinée, 59000 Lille, France.

Early stage ovarian epithelial cancer (stage I according to the FIGO classification, i.e. limited to ovaries) affects 20% to 33% of patients with ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.007DOI Listing
January 2019
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[Part I drafted from the short text of the French Guidelines entitled "Initial management of patients with epithelial ovarian cancer" developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY and endorsed by INCa. (Diagnosis management, surgery, perioperative care, and pathological analysis)].

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; UMRS-938, institut universitaire de cancérologie Sorbonne université, 75000 Paris, France.

Faced to an undetermined ovarian mass on ultrasound, an MRI is recommended and the ROMA score (combining CA125 and HE4) can be proposed (grade A). In case of suspected early stage ovarian or fallopian tube cancer, omentectomy (at least infracolonic), appendectomy, multiple peritoneal biopsies, peritoneal cytology (grade C) and pelvic and para-aortic lymphadenectomy are recommended (grade B) for all histological types, except for the expansive mucinous subtype where lymphadenectomy may be omitted (grade C). Minimally invasive surgery is recommended for early stage ovarian cancer, if there is no risk of tumor rupture (grade B). Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.010DOI Listing
January 2019

[Initial management of epithelial ovarian cancer. Methods and organization.Article written on the basis of French joint guidelines of CNGOF, FRANCOGYN, SFOG, GINECO-ARCAGY and INCa].

Gynecol Obstet Fertil Senol 2019 Jan 22. Epub 2019 Jan 22.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Tenon, Assistance publique des Hôpitaux de Paris (AP-HP), 75020 Paris, France; UMRS-938, faculté de médecine UPMC, institut universitaire de cancérologie (IUC), Centre CALG (Cancer associé à la grossesse), Sorbonne université, 75000 Paris, France.

This text presents organizational and methodological aspects of the development of the French guidelines on the initial management of epithelial ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.gofs.2018.12.016DOI Listing
January 2019

[Lower urinary tracts symptoms after female genital mutilation: A review].

Prog Urol 2019 Jan 22. Epub 2019 Jan 22.

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 92141 Clamart, France. Electronic address:

Introduction: The purpose of this article is to summarise the data available in literature on Lower Urinary Tract Symptoms [lower urinary tract symptoms (LUTS)] after female genital mutilation (MSF).

Methods: Our review identified 177 publications, 14 of which were included in the article.

Results: With regard to short-term complications, the prevalence of Acute Urinary Retention (RAU) after MSF is estimated between 3% and 12%. Read More

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http://dx.doi.org/10.1016/j.purol.2019.01.001DOI Listing
January 2019
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Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol.

Environ Int 2019 Mar 22;124:400-407. Epub 2019 Jan 22.

LABERCA, Oniris, INRA, Université Bretagne-Loire, 44307 Nantes, France. Electronic address:

Background: Endometriosis is a hormone-dependent gynaecological disease characterised by the presence and growth of endometrial tissues outside of the uterus. There is growing experimental evidence that suggests environmental endocrine disrupting chemicals, specifically organochlorine chemicals (OCCs), may play a role in the pathogenesis of endometriosis, but to date, there are no studies attempting to gather and synthesise the published literature systematically.

Objectives: The main objective of this SR is to evaluate the associations between the exposure to OCCs and endometriosis in experimental models (in vivo and in vitro). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183170
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http://dx.doi.org/10.1016/j.envint.2018.12.063DOI Listing
March 2019
5 Reads

The burden to be second twin: a population-based study of 2686 twins: (2124 dichorionic). Proposal of the concept of mobility.

J Matern Fetal Neonatal Med 2019 Jan 22:1-5. Epub 2019 Jan 22.

a Service de Réanimation néonatale , Centre Hospitalier Universitaire Sud-Réunion , Saint-Pierre , France.

Objectives: To identify if there is a specific neonatal morbidity/mortality among second twins relative to first twins.

Study Design: A 17-year (2001-2017) population-based observational cohort of all twin newborns born in the South of Reunion island after 21 weeks.

Results: Among 1062 dichorionic (DTP) and 281 monochorionic twin pregnancies (2686 newborns), twin 2 have a doubled risk to be in breech presentation and a bad Apgar at 1 mn (≤6) in vaginal deliveries. Read More

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http://dx.doi.org/10.1080/14767058.2019.1566308DOI Listing
January 2019
2 Reads

[Aspirin and preeclampsia].

Presse Med 2019 Jan 18;48(1 Pt 1):34-45. Epub 2019 Jan 18.

Assistance publique-Hôpital de Paris, centre hospitalier universitaire Cochin Broca Hôtel-Dieu, groupe hospitalier universitaire Ouest, département de gynécologie-obstétrique, maternité de Port-Royal, 53, avenue de l'Observatoire, 75014 Paris, France; PRES Sorbonne Paris Cité, université Paris Descartes, Paris, France; Fondation PremUP, Paris, France; DHU Risques et grossesse, Paris, France.

Indications for aspirin during pregnancy are a matter of debate and there is a recent trend to an extended prescription and an overuse of aspirin in pregnancy. Aspirin is efficient in secondary prevention of preeclampsia essentially in patients with a personal history of preeclampsia. The effect of aspirin on platelet aggregation and on the TXA2/PGI2 balance is dose-dependent. Read More

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http://dx.doi.org/10.1016/j.lpm.2018.11.022DOI Listing
January 2019
10 Reads

Ovarian Clear Cell Carcinoma in Cowden Syndrome.

J Natl Compr Canc Netw 2019 Jan;17(1):7-11

Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, Oncogénétique Clinique, CHU Montpellier, Université de Montpellier, Montpellier; Unité d'Oncogénétique, Institut Bergonié, INSERM U1218, Université de Bordeaux, Bordeaux; Département d'Oncologie Médicale, Service de Gynécologie-Obstétrique, and Service d'Anatomopathologie, CHU Montpellier, Université de Montpellier, Montpellier; Unité d'Anatomie Pathologique, Institut Bergonié, INSERM U1218, Université de Bordeaux, Bordeaux; Service de Dermatologie, CHU Montpellier, Université de Montpellier, Montpellier; Service d'Oncogénétique, Hôpital Pellegrin, CHU de Bordeaux; Service d'Oncogénétique, Hôpital Charles Nicolle, CHU de Rouen; and Service de Génétique Médicale, CHU de Toulouse, Université de Médecine Toulouse III, Toulouse, France.

Cowden syndrome (CS) is an autosomal dominant mendelian disease related to germline pathogenic variants affecting the -gene. CS is characterized by macrocephaly, mucocutaneous lesions, and an increased risk of breast and thyroid cancers. Rare ovarian cancer cases (mostly embryonic tumors) associated with have been described in the literature, but no current CS guidelines are available for ovarian cancer risk management. Read More

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http://dx.doi.org/10.6004/jnccn.2018.7065DOI Listing
January 2019
2 Reads

Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.

Chemosphere 2019 Apr 10;221:471-478. Epub 2019 Jan 10.

INRA (Institut National de la Recherche Agronomique), UMR1331 (Unité Mixe de Recherche 1331), Toxalim, Research Center in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, ENVT (Ecole Nationale Vétérinaire de Toulouse), EIP (Ecole d'Ingénieurs de Purpan), UPS (Université Paul Sabatier), F-31076 Toulouse Cedex 3, France. Electronic address:

The aim of our study was to evaluate the bidirectional transfer of Bisphenol S (BPS) and its main metabolite, BPS Glucuronide (BPSG), using the model of perfused human placenta and to compare the obtained values with those of Bisphenol A (BPA) and BPA Glucuronide. Fourteen placentas at term were perfused in an open dual circuit with deuterated BPS (1 and 5 μM) and non-labelled BPSG (2.5 μM) and a freely diffusing marker antipyrine (800 ng/ml) in the presence of albumin (25 mg/ml). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193006
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http://dx.doi.org/10.1016/j.chemosphere.2019.01.065DOI Listing
April 2019
4 Reads

Understanding attitudes and behaviors towards cell-free DNA-based noninvasive prenatal testing (NIPT): A survey of European health-care providers.

Eur J Med Genet 2019 Jan 14. Epub 2019 Jan 14.

Prenatal Genetic Diagnosis Unit, Genetic Institute, Tel Aviv Medical Center, Tel Aviv, Israel. Electronic address:

Cell-free DNA-based noninvasive prenatal testing (cfDNA) is a relatively new screening tool that analyzes cfDNA circulating in maternal plasma to screen for aneuploidies. Since its introduction, cfDNA has been rapidly adopted by health care providers (HCPs). This rapid adoption, as well as progressive developments in the technology, requires professional societies to continuously update their guidelines to indicate the broadening scope both in terms of test indications and patient populations for whom it has become the appropriate primary test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697212183071
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http://dx.doi.org/10.1016/j.ejmg.2019.01.006DOI Listing
January 2019
6 Reads

La littérature médicale mondiale : obstétrique.

Authors:
Amira El-Messidi

J Obstet Gynaecol Can 2019 Feb;41(2):152-155

Département d'obstétrique et de gynécologie, Université McGill, Montréal (Qc).

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http://dx.doi.org/10.1016/j.jogc.2018.12.016DOI Listing
February 2019

[Study of fetal heart rate abnormalities observed on cardiotocography in Lubumbashi: about a cases followed at the Lubumbashi University Clinic and the General Hospital of the Cinquantenaire].

Pan Afr Med J 2018 17;30:278. Epub 2018 Aug 17.

Département de Gynécologie-Obstétrique de la Faculté de Médecine de l'Université de Lubumbashi, Republique Démocratique du Congo.

Cardiotocography (CTG) has recently come into use in Lubumbashi but no thorough study has yet been conducted to identify its impact on perinatal morbi-mortality. This study aims to determine the frequency of fetal heart rate abnormalities (FHR)in order to identify the associated factors and to propose a suitable management. We conducted a cross-sectional, descriptive study of 411 women in labour over a period of 19 months (March 2015-December 2016). Read More

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http://dx.doi.org/10.11604/pamj.2018.30.278.13365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317385PMC
January 2019
3 Reads

Case report on early treatment with valaciclovir after maternal primary cytomegalovirus infection.

J Gynecol Obstet Hum Reprod 2019 Jan 8. Epub 2019 Jan 8.

Service de Gynécologie-Obstétrique, Hôpital Antoine Béclère, Université Paris-Sud, Clamart, France. Electronic address:

Background: Cytomegalovirus (CMV) is the main cause of congenital viral infections. Current guidelines do not include any recommendation about antenatal treatment. Most studies that evaluate the efficacy of valaciclovir aim to treat infected symptomatic fetus but the benefit of anti-CMV therapy remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847183041
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http://dx.doi.org/10.1016/j.jogoh.2019.01.003DOI Listing
January 2019
5 Reads

Point-of-Care Intrapartum Group B Streptococcus Molecular Screening: Effectiveness and Costs.

Obstet Gynecol 2019 Feb;133(2):276-281

Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, France-EA4043 Unité Bactéries Pathogènes et Santé, Université Paris-Sud Saclay, Chatenay-Malabry, Service de Néonatologie, Groupe Hospitalier Paris Saint-Joseph, Service de Gynécologie Obstétrique, Groupe Hospitalier Paris Saint-Joseph, France - UMR1153, Obstetrical, neonatal and pediatric epidemiology research team (EPOPé) - DHU Risk in pregnancy - Paris Descartes University, AP-HP Unité de Recherche Clinique en Economie de la Santé d'Ile-de-France, Hôpital de l'Hôtel Dieu, ECEVE, UMR1123, Université Paris Est Créteil, Paris France.

Objective: To assess outcomes and costs associated with around-the-clock point-of-care intrapartum group B streptococcus (GBS) polymerase chain reaction (PCR) screening.

Methods: Intrapartum PCR screening was implemented in 2010. Intrapartum PCR was compared with antenatal culture screening in an uncontrolled, single institution, preintervention and postintervention study. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003057DOI Listing
February 2019
14 Reads

[Preimplantation genetic testing].

Rev Med Suisse 2019 Jan;15(N° 632-633):53-56

Unité de médecine de la reproduction, Département de gynécologie et obstétrique, HUG, 1211 Genève 14.

Preimplantation genetic testing avoids the transmission of monogenic diseases or structural chromosome abnormality to the offspring in fertile couples. Furthermore, it allows screening for aneuploidies (PGT-A, Preimplantation genetic testing for aneuploidy), with the aim of selecting one euploid embryo before transfer in infertile couples undergoing in vitro fertilization (IVF). Indeed, aneuploidies are frequent and explain most IVF failures and early miscarriages. Read More

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January 2019
2 Reads

Corrigendum to infection with women's febrile spontaneous abortion reported in Algiers'.

New Microbes New Infect 2019 Jan 28;27:53. Epub 2018 Nov 28.

Aix-Marseille Université, IRD, VITROME, IHU Méditerranée Infection, Marseille, France.

[This corrects the article DOI: 10.1016/j.nmni. Read More

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http://dx.doi.org/10.1016/j.nmni.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305685PMC
January 2019

Reproducibility of fetal lung-to-head ratio in left diaphragmatic hernia across the North American Fetal Therapy Network (NAFTNet).

Prenat Diagn 2019 Jan 7. Epub 2019 Jan 7.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Objective: To determine the antenatal sonographic lung area measurement method in left congenital diaphragmatic hernia (CDH) with the highest interrater agreement among North American Fetal Therapy Network (NAFTNet) centers within and outside the fetoscopic tracheal occlusion (FETO) consortium and in comparison with a European "expert" reviewer (ER).

Methods: Nineteen members from nine FETO consortium centers and 29 reviewers from 17 non-FETO centers reviewed ultrasound clips of the chest from 13 fetuses with isolated left CDH and were asked to select a static plane for lung area measurement using anteroposterior (AP), longest, and trace methods. Interrater agreement in lung area measurements was determined using intraclass correlation coefficient (ICC). Read More

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http://dx.doi.org/10.1002/pd.5413DOI Listing
January 2019
2 Reads
2.514 Impact Factor

Socio-historical evolution of the episiotomy practice: A literature review.

Women Health 2019 Jan 7:1-15. Epub 2019 Jan 7.

c Polyclinic Majorelle , Nancy , France.

Episiotomy is an enlargement of the vaginal orifice made by a surgical incision of the perineum. This review aimed to provide a socio-historical retrospective on the practice or episiotomy. Using the criteria from the PRISMA guidelines, the authors conducted a literature review, browsing twenty databases and several papers available in the gray literature. Read More

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http://dx.doi.org/10.1080/03630242.2018.1553814DOI Listing
January 2019

Serum hCG threshold to assess medical abortion success.

Eur J Contracept Reprod Health Care 2018 Dec 2;23(6):458-463. Epub 2019 Jan 2.

a Département de Gynécologie, Obstétrique et Médecine de la Reproduction, CHU de Rennes, Hôpital Sud , Rennes , France.

Objectives: The main aim of the study was to establish a threshold for serum human chorionic gonadotropin (hCG) level that ruled out ongoing pregnancy after induced medical abortion (MA). The secondary aim was to discover risk factors for the need for uterine aspiration.

Methods: This prospective study included women who underwent MA with mifepristone-misoprostol at ≤9 weeks of gestation between 2012 and 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/13625187.2018.1
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http://dx.doi.org/10.1080/13625187.2018.1539162DOI Listing
December 2018
10 Reads

Erratum à l’article « Acétate d’Ulipristal et SPRM : une nouvelle entité pour définir de nouvelles stratégies thérapeutiques pour les fibromes symptomatiques » [Gynecol. Obstet. Fertil. Senol. 46 (2018) 671–672].

Authors:
H Fernandez

Gynecol Obstet Fertil Senol 2019 01 27;47(1):90. Epub 2018 Dec 27.

Service gynécologie obstétrique, CHU Bicêtre, GHU-Sud, AP-HP, 78, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France; Faculté de médecine Paris-Sud Saclay, 63, rue Gabriel-Péri, 94270 Le Kremlin-Bicêtre, France; CESP-Inserm U1018 « Reproduction et Développement de l'enfant », 82, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.gofs.2018.12.001DOI Listing
January 2019

Corpus Callosum Abnormalities and Short Femurs in Beckwith-Wiedemann Syndrome: A Report of Two Fetal Cases.

Fetal Pediatr Pathol 2018 Dec 31:1-7. Epub 2018 Dec 31.

a Unité d'Embryofœtopathologie, Service d'Histologie-Embryologie-Cytogénétique, Hôpital Necker-Enfants Malades, APHP , Paris , France.

Introduction: Beckwith-Wiedemann syndrome (BWS) is the most common overgrowth syndrome. Clinical features are highly variable, including occasional posterior fossa malformations but no femoral shortening.

Case Report: We report two fetuses with BWS associated with short femurs and corpus callosum hypoplasia. Read More

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http://dx.doi.org/10.1080/15513815.2018.1520942DOI Listing
December 2018
2 Reads

When can obstetric risk be predicted?

J Gynecol Obstet Hum Reprod 2018 Dec 21. Epub 2018 Dec 21.

Service de gynécologie obstétrique CH de la Croix Rousse, France.

Objective: The aim of the study was to assess the chronology of the appearance of perpartum obstetric risk factors (POR) in order to define the best moment to evaluate the type of management to which women will be oriented. We have secondarily studied the extent to which inappropriate medical interventions play a role in the genesis of some complications in the deliveries of women who are in principle at low risk.

Materials And Methods: We conducted a prospective cohort study from January 1 to June 30, 2015 at the Croix-Rousse Hospital of Lyon, a level III maternity, and the Valence Hospital Center, a level II maternity, including all women giving birth at 24 to 42 weeks of gestation at hospital. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.12.006DOI Listing
December 2018
1 Read

[Human Resources for Unplanned Activities in Obstetrics and Gynecology. Consensus statements by the CNGOF, CARO, CNSF, FFRSP, SFAR, SFMP and SFN].

Gynecol Obstet Fertil Senol 2019 01 20;47(1):63-78. Epub 2018 Dec 20.

Société française d'anesthésie-réanimation (SFAR), 74, rue Raynouard, 75016 Paris, France; Club d'anesthésie-réanimation en obstétrique (CARO), 23, boulevard de Port-Royal, 75014 Paris, France; Pôle d'anesthésie-réanimation, maternité Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, 1, avenue Eugène-Avinée, 59000 Lille, France.

Objective: To determine a minimum threshold of human resources (midwives, obstetricians and gynecologists, anesthesiology and intensive care units, pediatricians) to ensure the safety and quality of unplanned activities in Obstetrics and Gynecology.

Materials And Methods: Consultation of the MedLine database, the Cochrane Library and the recommendations of authorities. Meetings of representative members in different modes of practice (university, hospital, liberal) under the aegis of and belonging to the French College of Obstetricians and Gynecologists (CNGOF), the French Society of Anesthesia and Resuscitation (SFAR), the French Society of Neonatalogy (SFN), the French Society of Perinatal Medicine (SFMP), the French College of Midwives (CNSF), the French Federation of Perinatal Care Networks (FFRSP) with elaboration of a re-read text by external experts, in particular by the members of the Boards of Directors of these authorities and of Club of Anesthesiology-Intensive Care Medicine in Obstetrics (CARO). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189183031
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http://dx.doi.org/10.1016/j.gofs.2018.11.001DOI Listing
January 2019
2 Reads