46,701 results match your criteria Gynecologic and Obstetric Investigation[Journal]


Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade).

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S93-S113

Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, Mexico City Hospital of Oncology, Mexico City, Mexico (I.A.-C.) Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada (M.A.D.) Department of Pathology, Wayne State University, Detroit, Michigan (R.A.-F.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (E.E., A.M.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School (M.N.) Department of Pathology, Massachusetts General Hospital, Harvard Medical School (E.O.), Boston, Massachusetts Division of Gynecologic, Breast & Perinatal Pathology, University Hospital Leipzig, Leipzig (L.-C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Anatomical Pathology, University of Maryland, College Park, Maryland (O.I.) Pathological Oncology Group and Pathology Department, University Hospital of Arnau de Vilanova, Lleida (X.M.-G.) Department of Pathology, Hospital Clinic of Barcelona, ISGlobal, Barcelona Center for International Health Research, University of Barcelona, Barcelona (J.O.), Spain Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Pathology, Women and Infants Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.).

Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Read More

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January 2019

Guidelines to Aid in the Distinction of Endometrial and Endocervical Carcinomas, and the Distinction of Independent Primary Carcinomas of the Endometrium and Adnexa From Metastatic Spread Between These and Other Sites.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S75-S92

Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia (C.J.R.S.) Department of Pathology, Brigham and Women's Hospital (C.P.C.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK (W.G.M.) Department of Pathology, Memorial-Sloan Kettering Cancer Center, New York, New York (K.J.P.) Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California (J.K.R.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Pathological Oncology Group and Pathology Department, Hospital Arnau de Vilanova, Lleida, Spain (X.M.-G.) Departments of Pathology and Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland (B.M.R.).

In most cases of suspected endometrial neoplasia tumor origin can be correctly assigned according to a combination of clinical, radiologic, and pathologic features, even when the latter are based upon the examination of relatively small biopsy samples. However there are well-recognized exceptions to this rule which continue to create diagnostic difficulty, and sometimes difficulties persist even after the detailed examination of resection specimens. Among the most common problems encountered in practice are the distinction of primary endometrial and primary endocervical adenocarcinomas, and the determination of tumor origin when there is synchronous, multifocal involvement of gynecologic tract sites, for example the endometrium and the ovary. Read More

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January 2019

Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S9-S24

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M., E.D.E.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Wayne State University, Detroit, Michigan (R.A.F.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.), UK Division of Gynecologic, Breast and Perinatal Pathology, University Hospital, Leipzig (L.C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Pathology, Hospital de Oncología Siglo XXI, Mexico City, Mexico City, Mexico (I.A.C.) Department of Pathology, Hospital Universitari de Bellvitge and Hospital Universitari de Arnau de Vilanova, Idibell, Irblleida, and Universitat de Lleida, Ciberonc (X.M.G.) Department of Pathology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona (J.O.), Spain Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada (M.D.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Women and Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection-including sentinel lymph nodes. In addition, the intraoperative assessment of some of these specimens is addressed. Read More

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January 2019

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient.

Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients.

Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). Read More

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December 2018

Safe and easy technique for the laparoscopic application of Seprafilm® in gynecologic surgery.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.

Introduction: Laparoscopic surgery is a minimally invasive surgery, and the rate of postoperative adhesions is low. Although Seprafilm® helps to reduce adhesions, its application in the abdominal cavity during laparoscopic surgery is difficult because of its material. Therefore, we propose an easy method for applying this adhesion barrier. Read More

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December 2018

Differential gene expression profile in monocytic myeloid-derived suppressor cells at maternal-fetal interface in a mouse model of spontaneous abortion.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Abstractbackground: Monocytic myeloid-derived suppressor cells (MO-MDSCs) play an important role in maintaining normal pregnancy. However, it is still not clear what kind of changes in MO-MDSCs may lead to miscarriage, and which gene expression changes take place when MO-MDSCs migrate to the uterus as bone marrow-derived cells.

Methods: We used flow sorting technology to obtain MO-MDSCs from the maternal-fetal interface and bone marrow, respectively. Read More

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December 2018

Significance of progesterone receptors (PR-A and PR-B) expression as predictors for relapse after successful therapy of endometrial hyperplasia: A retrospective cohort study.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

Research Group for Gynecologic Oncology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

Objective: After successful progestin therapy for endometrial hyperplasia (EH), the risk of relapse remains. We aimed to assess if immunohistochemical (IHC) expression of progesterone receptor isoforms, PR-A and PR-B, in endometrial glands and stroma in pre-treatment endometrial biopsies were related to relapse of EH.

Design And Setting: Biopsy material originated from women with low- and medium-risk EH recruited to a recent Norwegian multicentre randomized trial. Read More

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December 2018

Exercise Interventions to Manage Fatigue in Women With Gynecologic Cancer: A Systematic Review.

Oncol Nurs Forum 2019 Jan;46(1):71-82

Ulster University.

Problem Identification: Fatigue has a negative impact on the quality of life of patients with cancer. The aim of this review is to evaluate studies on the effectiveness of exercise interventions in reducing fatigue in women with gynecologic cancer.

Literature Search: The review was conducted according to the PRISMA guidelines using the CINAHL®, MEDLINE®, EMBASE, PsycINFO®, and Cochrane Library databases. Read More

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January 2019

Solitary right ventricular metastasis of endometrial adenocarcinoma.

J Cardiol Cases 2015 Jan 14;11(1):32-34. Epub 2014 Nov 14.

Department of Medicine - Cardiology, University of Bonn, Bonn, Germany.

A woman presented with a solitary cardiac metastasis 5 months after curative surgery for endometrial adenocarcinoma (FIGO IB). The tumor was deemed inoperable and palliative ambulatory chemotherapy was initiated. We aimed at a palliative reduction of tumor mass after chemotherapy and atypical vascularization of the metastasis was demonstrated by coronary angiography. Read More

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January 2015

Data on post-partum evaluation of women with abnormal cervical cytology in pregnancy.

Data Brief 2018 Dec 22;21:2405-2409. Epub 2018 Nov 22.

Gynecological Oncology Unit, Centro di Riferimento Oncologico - National Cancer Institute, Via F. Gallini 2, Aviano, Italy.

During pregnancy, the only diagnosis that may alter management is invasive cancer. Thus, the primary aim of the cytological screening and subsequent colposcopy performed during pregnancy should be the exclusion of invasive cancer, "Practice Bulletin No. 140: management of abnormal cervical cancer screening test results and cervical cancer precursors," (American College of Obstetricians and Gynecologists, 2013) [1]. Read More

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December 2018

TNFAIP8 promotes cell growth by regulating the Hippo pathway in epithelial ovarian cancer.

Exp Ther Med 2018 Dec 2;16(6):4975-4982. Epub 2018 Oct 2.

Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is an independent prognostic factor for cancer-specific and disease-free survival in patients with epithelial ovarian cancer (EOC). However, the exact mechanism of the biological role of TNFAIP8 in EOC remains unclear. In the present study, a siRNA specifically targeting TNFAIP8 was prepared to knock down TNFAIP8 in EOC cells. Read More

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December 2018

A correlation study of fear of cancer recurrence, illness representation, self-regulation, and quality of life among gynecologic cancer survivors in Taiwan.

Taiwan J Obstet Gynecol 2018 Dec;57(6):846-852

College of Nursing and Health Sciences, Dayeh University, Changhua, Taiwan; Mackay Memorial Hospital, Taipei City, Taiwan; Department of Nursing, Mackay Junior College of Medicine, Nursing, and Management, Taipei City, Taiwan; Department of Nursing, Mackay Medical College, New Taipei City, Taiwan. Electronic address:

Objective: The purpose of this study was to examine the correlations among fear of cancer recurrence (FCR), illness representation (IR), self-regulation (SR), and quality of life (QOL) in gynecologic cancer survivors.

Materials And Methods: A cross-sectional study was conducted with 287 participants recruited from a medical center in northern Taiwan. Four questionnaires, the Assessment of Survivor Concerns (ASC), the Brief Illness Perception Questionnaire (BIPQ), the Self-Regulation Questionnaire (SRQ), and the European Organization for Research and Treatment of Cancer's Quality-of-Life Questionnaire-Core 30-item (EORTC QLQ-C30), were used to assess FCR, IR, SR, and QOL respectively. Read More

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December 2018

Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.

Gynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. Read More

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December 2018

Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13470

Department of Obstetrics and Gynecology.

In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20. Read More

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December 2018
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Impact of hospital care volume on clinical outcomes of laparoscopic radical hysterectomy for cervical cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13445

Division of Gynecologic Oncology, Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA.

Background: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer.

Methods: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy. Read More

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December 2018

Why do breast cancer survivors decline a couple-based intimacy enhancement intervention trial?

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.

Recruitment challenges hinder behavioral intervention research in cancer survivors. The purpose was to examine the reasons for declining and intervention preferences of study-eligible breast cancer survivors declining a trial of a four-session couple-based Intimacy Enhancement intervention (refusers) and explore whether refusers differed from participants on key characteristics. Partnered, post-treatment breast cancer survivors reporting sexual concerns who were eligible for but declined participation in the intervention trial were approached to complete a standardized 5-min telephone survey assessing reasons for declining and support preferences. Read More

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December 2018

Current Activities of the Coalition of Cancer Cooperative Groups.

J Natl Cancer Inst 2018 Dec 13. Epub 2018 Dec 13.

National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA.

The Coalition of Cancer Cooperative Groups is an organization representing the interests of patients and researchers who conduct research through the National Cancer Institute-supported National Clinical Trials Network (NCTN). The NCTN provides a crucial mechanism for executing practice-changing cancer clinical research to achieve both cancer control and development of new therapeutic agents or modality approaches. Public funding, largely through the National Cancer Institute, ensures that the work of the NCTN achieves important research that would not otherwise be accomplished in the private sector. Read More

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December 2018

A Cell-Based Method for Identification of Chemotherapy Resistance Cancer Genes.

Methods Mol Biol 2019 ;1907:83-90

Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN, USA.

Here we describe a method for identifying genes and genetic pathways responsible for chemoresistance in cancer cells. The method is based on generation and characterization of matched pairs of chemotherapy-sensitive/chemotherapy-resistant cancer cell lines. In this protocol we are using endometrial cancer cell lines treated with carboplatin and paclitaxel, which are first-line chemotherapies for gynecologic malignancies. Read More

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January 2019

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET.

Chem Sci 2018 Nov 11;9(42):8046-8055. Epub 2018 Sep 11.

NanoBioPhotonics , Institute for Integrative Biology of the Cell (I2BC) , Université Paris-Saclay , Université Paris-Sud , CNRS , CEA , Orsay , France . Email: ; https://www.nanofret.com.

MicroRNAs (miRNAs) play an important role in cellular functions and in the development and progression of cancer. Precise quantification of endogenous miRNAs from different clinical patient and control samples combined with a one-to-one comparison to standard technologies is a challenging but necessary endeavor that is largely neglected by many emerging fluorescence technologies. Here, we present a simple, precise, sensitive, and specific ratiometric assay for absolute quantification of miRNAs. Read More

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November 2018

Functional Loss Defines a Targetable Subset in Leiomyosarcoma.

Oncologist 2018 Dec 12. Epub 2018 Dec 12.

Division of Bioinformatics, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA

Background: Soft-tissue sarcomas (STS) describe a heterogeneous group of mesenchymal tumors with limited treatment options. Targeted therapies exist for gene alterations, but their prevalence and role have not been fully described in STS. Here, we present the largest effort to characterize the frequency of homologous recombination (HR) DNA repair pathway alterations in STS subtypes and highlight the unique nature of leiomyosarcoma (LMS). Read More

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December 2018

CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer.

J Immunol Res 2018 7;2018:6156757. Epub 2018 Nov 7.

Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

There are rapidly emerging efforts to explore tumor-associated macrophages (TAMs) as a tumor therapy target. Tumor cells express CD47, which can interact with the macrophages' SIRP transmitting a "don't eat me" signal to macrophages. The expression of CD47 increases in various tumors to evade immune attack. Read More

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November 2018

Expression of Insulinoma-Associated Protein 1 (INSM1) and Orthopedia Homeobox (OTP) in Tumors with Neuroendocrine Differentiation at Rare Sites.

Endocr Pathol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumors of pulmonary origin. Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation. Read More

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December 2018

South African General Surgeon Preparedness for Humanitarian Disasters.

World J Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Humanitarian medical organizations provide surgical care for a broad range of conditions including general surgical (GS), obstetric and gynecologic (OBGYN), orthopedic (ORTHO), and urologic (URO) conditions in unstable contexts. The most common humanitarian operation is cesarean section. The objective of this study was to identify the proportion of South African general surgeons who had operative experience and current competency in GS, OBGYN, ORTHO, and URO humanitarian operations in order to evaluate their potential for working in humanitarian disasters. Read More

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December 2018

Molecular subtype not immune response drives outcomes in endometrial carcinoma.

Clin Cancer Res 2018 Dec 6. Epub 2018 Dec 6.

Division of Gynecologic Oncology, Department of Gynecology and Obstetrics, University of British Columbia

Purpose: Tumors with high mutation load are thought to engender stronger immune responses which in turn promote prolonged patient survival. To investigate this, we assessed tumor-infiltrating lymphocytes (TIL) and immunosuppressive factors across the four molecular subtypes of endometrial cancer (EC), which have characteristic mutation rates ranging from low to ultra-high.

Experimental Design: 460 ECs were stratified by ProMisE (Proactive Molecular Risk Classifier in Endometrial cancer) into four molecular subtypes: mismatch repair-deficient (MMRd), POLE mutant (POLE), p53 abnormal (p53abn), and p53 wildtype (p53wt). Read More

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December 2018

A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer.

Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,

Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More

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December 2018

Cell-based immunotherapy in gynecologic malignancies.

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Women's Cancer Center, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.

Recent Findings: Improvements have been made in engineering T cells to overcome the immunosuppressive environment in ovarian cancer. Significant efforts are underway to create 'off the shelf' cell therapies which leverage natural killer (NK) cells and would not rely on engineering a patient's T cells. Read More

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December 2018

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.

Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More

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December 2018

Screening of Cervical Cancer with Self-Collected Cervical Samples and Next-Generation Sequencing.

Dis Markers 2018 14;2018:4826547. Epub 2018 Nov 14.

Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cervical cancer is the second leading cause of death in female genital malignancies. Persistent infection with high-risk HPV is closely related to cervical intraepithelial neoplasia (CIN). Wide-scale HPV screening has already been implemented in developed countries. Read More

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November 2018

Pelvic Exenteration Put into Therapeutical and Palliative Perspective: It Is Worth to Try.

Indian J Surg Oncol 2018 Dec 20;9(4):552-557. Epub 2018 Jul 20.

22nd Department of Surgery, Attikon Hospital, University of Athens Medical School, 1 Rimini Str, 124 10 Chaidari, Greece.

Pelvic exenteration (PE) is one of the most drastic operations in surgical oncology, associated with severe morbidity and mortality. The objective of our study was to review our experience of PE in terms of surgical characteristics, complications, and overall survival. All patients who had PE surgery between January 1999 and December 2015 were identified. Read More

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December 2018

Challenges in the identification of inherited risk of ovarian cancer: where should we go from here?

Gynecol Oncol 2018 Dec 8. Epub 2018 Dec 8.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States of America. Electronic address:

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December 2018

Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Aberrant activation of cyclin-dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, we report that CDK9 is gradually upregulated during cervical lesion progression and regulated by HPV16 E6. Read More

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December 2018

The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study.

Int Urogynecol J 2018 Dec 10. Epub 2018 Dec 10.

Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Introduction And Hypothesis: Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population. Read More

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December 2018

Factors associated with post-relapse survival in patients with recurrent cervical cancer: the value of the inflammation-based Glasgow Prognostic Score.

Arch Gynecol Obstet 2018 Dec 10. Epub 2018 Dec 10.

Gynecologic Cancer Unit, Department of Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.

Purpose: The aim of the present study was to assess the value of the Glasgow Prognostic Score (GPS) as a prognostic tool for predicting post-relapse survival (PRS) in patients with recurrent cervical cancer.

Methods: We retrospectively evaluated the data of 116 patients with recurrent cervical cancer in whom serologic biomarkers had been assessed at the time of relapse. The GPS was calculated as follows: patients with elevated serum C-reactive protein levels and hypoalbuminemia were allocated a score of 2, and those with 1 or no abnormal value were allocated a score of 1 and 0, respectively. Read More

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December 2018
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Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer.

Curr Treat Options Oncol 2018 Nov 15;19(12). Epub 2018 Nov 15.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler Dr. CPB 6.3279, Houston, TX, 77030, USA.

Opinion Statement: Use of poly(ADP-ribose) polymerase (PARP) inhibitors has greatly increased over the past 5 years. With several new Food and Drug Administration (FDA) approvals, three PARP inhibitors have entered into standard of care treatment for epithelial ovarian cancer (including ovarian, fallopian tube, and primary peritoneal cancer). Olaparib and rucaparib currently have indications for treatment of recurrent BRCA mutant ovarian cancer. Read More

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November 2018

Cytology of the fallopian tube: A screening model for high-grade serous carcinoma.

Cytojournal 2018 12;15:28. Epub 2018 Nov 12.

Address: Department of Medical and Surgical Gynecology, Mayo Clinic, Jacksonville, FL, USA.

Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Read More

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November 2018
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Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis.

Gynecol Oncol Rep 2019 Feb 22;27:8-10. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology, Division of Gynecology and Gynecologic Subspecialties, University of Wisconsin Hospital and Clinics, Madison, WI, United States.

Background: Various ovarian neoplasms may show histological findings that are morphologically indistinguishable from adult granulosa cell tumor (AGCT).

Case Presentation: A 36 year-old women presented with left lower extremity pain and numbness. Ultrasound revealed a 10 cm left adnexal mass treated with ovarian cystectomy. Read More

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February 2019

Cardiovascular disease in women diagnosed with endometrial cancer.

Gynecol Oncol Rep 2018 Nov 4;26:108. Epub 2018 Aug 4.

Department of Gynecologic Oncology, Imperial College Healthcare NHS Trust, Du Cane Road, W12 0HS London, United Kingdom.

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November 2018

A case of primary cervical lymphoma in a patient with abnormal uterine bleeding.

Gynecol Oncol Rep 2018 Nov 2;26:105-107. Epub 2018 Nov 2.

Department of Gynecologic Oncology, Baptist Health Medical Group, 1740 Nicholasville Rd, Lexington, KY, 40503, United States.

Primary lymphoma of the uterine cervix is a rare site of extranodal lymphoma. Many gynecologic oncologists may go their entire career without encountering one. Patients may present with symptoms of abnormal or postmenopausal bleeding, and diagnosis may be challenging as typical office tests such as the pap smear may not detect the abnormal cells. Read More

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November 2018

hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman.

Gynecol Oncol Rep 2018 Nov 31;26:102-104. Epub 2018 Oct 31.

Division of Gynecologic Oncology, The University of Iowa Hospitals and Clinics, United States.

When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Read More

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November 2018

A retrospective study of surgical treatment and outcome among women with adnexal torsion in eastern Taiwan from 2010 to 2015.

PeerJ 2018 4;6:e5995. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan, Taiwan.

Background: Adnexal torsion is a gynecologic emergency that requires surgical treatment. In this study, we reviewed the surgical outcomes of women with adnexal torsion in eastern Taiwan (Hualien county, area 4,629 km, 330,000 residents).

Methods: This retrospective study included 42 women diagnosed with surgically-proven adnexal torsion from January 1, 2010, to September 31, 2015. Read More

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December 2018

Clinical validation of the Cervista high-risk human papillomavirus test in Chinese women from Fujian province: a cross-sectional study.

Ther Clin Risk Manag 2018 16;14:2243-2253. Epub 2018 Nov 16.

Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China,

Purpose: To estimate the high-risk human papillomavirus (HR-HPV) prevalence in a hospital-based population using the Cervista and to determine the clinical value and significance of Cervista for cervical cancer screening in Fujian Province, China.

Patients And Methods: In a hospital-based population, a total of 10,771 women from the Fujian Province were screened for cervical cancer and precancerous lesions using the thinprep cytologic test (TCT) and/or the Cervista. Women with HR-HPV infection and/or abnormal TCT were referred for colposcopy and biopsy. Read More

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November 2018

Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients.

Med Sci Monit 2018 Dec 10;24:8933-8940. Epub 2018 Dec 10.

Anesthesia Center, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China (mainland).

BACKGROUND ITGB8 encodes a β subunit of integrin (integrin β8), which is upregulated in some types of cancer. In the current study, we examined the expression profile of ITGB8 in serous ovarian cancer (SOVC) and investigated its potential as an independent prognostic indicator for overall survival (OS) and recurrence-free survival (RFS) in high-grade SOVC. MATERIAL AND METHODS A secondary study was conducted based on genomic and survival data in large online databases, including the Gene Expression Omnibus (GEO), the Human Protein Atlas (HPA), and the Cancer Genome Atlas-Ovarian cancer (TCGA-OV). Read More

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December 2018

Recent advances in gynecologic radiation oncology.

Curr Opin Obstet Gynecol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiation Oncology, University of California, Los Angeles, USA.

Purpose Of Review: Radiation has long been a primary treatment modality in locally advanced gynecologic carcinomas and a tool for palliation of metastatic disease. Here we review advances in imaging and radiation technologies and the corresponding clinical evolution of the role for radiation oncology in the treatment of gynecologic malignancies.

Recent Findings: Advances in MRI are impacting diagnosis, radiation target delineation, planning, treatment delivery, and response assessment. Read More

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December 2018

Examining Disparities in Route of Surgery and Postoperative Complications in Black Race and Hysterectomy.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, and the Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, Illinois.

Objective: To estimate the associations among race, route of hysterectomy, and postoperative complications among women undergoing hysterectomy for benign indications.

Methods: A cohort study was performed. All patients undergoing hysterectomy for benign indications, recorded in the National Surgical Quality Improvement Program and its targeted hysterectomy file in 2015, were identified. Read More

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December 2018

Challenges and Opportunities in Adolescent Gynecology Patients with Surgically-Treated Congenital and Acquired Anomalies: Transition of Care from Pediatric to Adult Surgery.

J Pediatr Adolesc Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of obstetrics and gynecology, university of Louisville, USA.

The transition from adolescence to young adulthood in patients with reproductive health care needs such as disorders of sexual development (DSDs) and congenital anomalies is a complex process occurring over several years. The transition process for these patients has is still poorly understood. The patients with DSDs and reproductive issues have specific and unique issues regarding timing of disclosure of diagnosis, genital examinations, gonadectomy, vaginal treatments, surgical procedures hormone replacement therapy, use of long term medication and potential cancer screening. Read More

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December 2018

Prevalence and Awareness of Pelvic Floor Disorders in Adolescent Females Seeking Gynecologic Care.

J Pediatr Adolesc Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.

Objective: To determine the prevalence and awareness of pelvic floor disorder (PFD) symptoms among adolescent females.

Design: Cross-sectional study via a written, anonymous survey of adolescents. The survey was composed of validated measures for determination of symptom prevalence. Read More

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December 2018

Oncologic and Surgical Outcomes of Robotic Versus Open Radical Hysterectomy for Cervical Cancer.

J Obstet Gynaecol Can 2018 Dec 7. Epub 2018 Dec 7.

Division of Gynecologic Oncology, Segal Cancer Centre, Lady Davis Institute of Research, Jewish General Hospital, McGill University, Montreal, QC. Electronic address:

Objective: In view of the recent controversy concerning the use of minimally invasive radical hysterectomy as primary treatment for early stage cervical cancer, this study compared the survival and perioperative outcomes in a cohort of patients who underwent radical hysterectomy either by laparotomy or by robotics.

Methods: This retrospective study compared all consecutive patients with early stage cervical cancer since the beginning of the Division of Gynecologic Oncology at the Jewish General Hospital in 2003, who underwent robotic radical hysterectomy (n = 74) with a cohort of all consecutive patients from the immediate past who underwent open radical hysterectomy (n = 24) for early stage cervical cancer. All patients were treated at the Jewish General Hospital in Montréal (Canadian Task Force Classification II-2). Read More

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December 2018
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Disseminating universal genetic testing to a diverse, indigent patient population at a county hospital gynecologic oncology clinic.

Gynecol Oncol 2018 Dec 8. Epub 2018 Dec 8.

The Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, TX, USA.

Objective: The universal genetic testing initiative (UGTI) is a quality improvement effort to increase rates of guideline-based genetic counseling (GC) and genetic testing (GT) of patients with potentially hereditary cancers. The UGTI was disseminated to a county hospital gynecologic oncology clinic that serves a diverse, indigent patient population.

Methods: Using the Model for Improvement quality improvement framework, interventions including integrated GC, clinic tracking, assisted GC referrals, and provider education were tested over 26 months. Read More

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December 2018

Effectiveness of hysteroscopic techniques for endometrial polyps removal: the italian multicenter Trial.

J Minim Invasive Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Women's Health and Territorial Medicine, University of Rome "La Sapienza", Rome, Italy.

Study Objective: To compare the effectiveness and safety of different techniques of hysteroscopic polypectomy.

Design: Multicenter, prospective observational trial (Canadian Task Force Classification II-2).

Setting: 19 Italian Gynecologic Departments (University-Affiliated or Public Hospitals). Read More

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December 2018

Scoping Review and Gap Analysis of Research Related to the Health of Women in the U.S. Military, 2000 to 2015.

J Obstet Gynecol Neonatal Nurs 2018 Dec 7. Epub 2018 Dec 7.

Objective: To synthesize the results of a scoping review and analysis of health care use data to identify gaps in knowledge related to the health of women in the U.S. military. Read More

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December 2018