3,995 results match your criteria Gynecologic and Obstetric Investigation[Journal]


Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders.

Gynecol Obstet Invest 2019 Feb 13:1-11. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background/aims: The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders.

Methods: A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. Microarray analysis and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to extract upregulated genes in the adherent site. Read More

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http://dx.doi.org/10.1159/000496609DOI Listing
February 2019

Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis.

Gynecol Obstet Invest 2019 Feb 1:1-10. Epub 2019 Feb 1.

Department of Obstetrics and Gynecology, University of São Paulo Medical School, São Paulo, Brazil.

Objective: The objective of this study was to evaluate cytokines related to natural killer and T-regulatory cells in endometriotic lesions, peritoneal fluid (PF) and the peripheral blood (PB) of patients with deep infiltrative endometriosis.

Study Design: A case-control study was conducted in a tertiary referral hospital. Sixty-four consecutive patients after laparoscopy were divided into 2 groups: with endometriosis (Group A - n = 32) and without endometriosis (Group B - n = 32). Read More

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http://dx.doi.org/10.1159/000496607DOI Listing
February 2019

Reported Outcomes in Perinatal Iron Deficiency Anemia Trials: A Systematic Review.

Gynecol Obstet Invest 2019 Feb 1:1-18. Epub 2019 Feb 1.

Women's Health Research Unit, Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University of London, London, United Kingdom.

Background/aims: Iron deficiency (ID) and iron deficiency anemia (IDA) are global health concerns associated with adverse perinatal effects. Despite efforts taken at the international level, there is no consensus on unified prevention/treatment strategies, largely stemming from inconsistencies of outcome reporting. Our objective was to comprehensively assess outcome reporting perinatal iron intervention trials as Phase 1 of core outcome set (COS) development to inform future research. Read More

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http://dx.doi.org/10.1159/000495566DOI Listing
February 2019
3 Reads

Normality Ranges of Menstrual Fluid Volume During Reproductive Life Using Direct Quantification of Menses with Vaginal Cups.

Gynecol Obstet Invest 2019 Feb 1:1-6. Epub 2019 Feb 1.

Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago, Chile.

Objective: To determine the normal limits of menstrual fluid volume during reproductive life, quantified by direct measurement.

Methods: This was an observational, prospective clinical trial of healthy women aged 20-49 years old, with normal menstrual periods, recruited in a Natural Family Planning Unit. Women collected their menstrual fluid for at least 3 menstrual periods using a vaginal cup. Read More

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http://dx.doi.org/10.1159/000496608DOI Listing
February 2019

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green.

Gynecol Obstet Invest 2019 Jan 18:1-7. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS "Sacro Cuore" Hospital, Verona, Italy.

Background: The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping.

Objectives: To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG).

Methods: A prospective observational study without control on 110 patients with endometrial cancer apparently confined to the uterus, underwent laparoscopic surgical staging with SLN mapping with ICG. Read More

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http://dx.doi.org/10.1159/000496699DOI Listing
January 2019

The Effect of Preoperative Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio on Predicting Rupture Risk in Tubal Ectopic Pregnancies.

Gynecol Obstet Invest 2019 Jan 17:1-5. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, TOBB University Faculty of Medicine, Ankara, Turkey.

Background: Consecutive measurements of β-hCG levels and sonographic evaluation of adnexae are critical for choosing the optimal management in ampullar tubal ectopic pregnancies (EP). To select suitable patients for conservative approach, there is a need for an affordable and reliable marker for determining rupture risk. Evaluation of systemic inflammatory markers in combination with serum β-hCG levels and ultrasound might help to decide the appropriate treatment option. Read More

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https://www.karger.com/Article/FullText/496543
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http://dx.doi.org/10.1159/000496543DOI Listing
January 2019
7 Reads

Deregulated microRNAs and Adiponectin in Postmenopausal Women with Breast Cancer.

Gynecol Obstet Invest 2019 Jan 16:1-9. Epub 2019 Jan 16.

Pathology Department of Regional Hospital 251, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Background: Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-221-3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. Read More

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http://dx.doi.org/10.1159/000496340DOI Listing
January 2019
1 Read

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe.

Gynecol Obstet Invest 2019 Jan 11:1-9. Epub 2019 Jan 11.

Centre for Surgical Technologies, KU Leuven, Leuven,

Background/aims: The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan.

Methods: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; ≥6 ewes/group). Read More

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http://dx.doi.org/10.1159/000495348DOI Listing
January 2019
4 Reads

Nutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational Studies.

Gynecol Obstet Invest 2019 Jan 10:1-16. Epub 2019 Jan 10.

Department of Midwifery, School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: The incidence and severity of primary dysmenorrhea are influenced by various factors. The aim of the present study was to review nutritional factors influencing primary dysmenorrhea.

Methods: Academic databases including Web of Science, EMBASE, Scopus, and PubMed (including Medline) were searched using keywords of nutrition, diet, and primary dysmenorrhea. Read More

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https://www.karger.com/Article/FullText/495408
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http://dx.doi.org/10.1159/000495408DOI Listing
January 2019
1 Read

Identifying Molecular Markers of Cervical Cancer Based on Competing Endogenous RNA Network Analysis.

Gynecol Obstet Invest 2019 Jan 9:1-10. Epub 2019 Jan 9.

Aim: Recurrence being a major challenge for the treatment of cervical cancer, we aimed at identifying novel molecular markers of cervical cancer to improve recurrence prediction.

Methods: Cervical cancer samples were obtained from the Cancer Genome Atlas. Prognosis-associated long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs between recurrent and nonrecurrent samples were acquired using expression analysis. Read More

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https://www.karger.com/Article/FullText/493476
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http://dx.doi.org/10.1159/000493476DOI Listing
January 2019
5 Reads
1.251 Impact Factor

Comparison of Efficacy between Internal Iliac Artery and Abdominal Aorta Balloon Occlusions in Pernicious Placenta Previa Patients with Placenta Accrete.

Gynecol Obstet Invest 2019 Jan 9:1-7. Epub 2019 Jan 9.

Background: We aimed to compare the hemostatic effect and perioperative outcomes between internal iliac artery (IIA) and abdominal aorta (AA) balloon occlusions in pernicious placenta previa patients complicated with placenta accrete and underwent cesarean delivery.

Methods: One hundred and twenty-three pernicious placenta previa patients complicated with placenta accrete were retrospectively reviewed. Patients who received IIA or AA occlusions were subsequently divided into the IIA group (n = 71) and AA group (n = 52). Read More

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http://dx.doi.org/10.1159/000494493DOI Listing
January 2019
1 Read

Effectiveness and Adverse Events of Early Laparoscopic Therapy versus Conservative Treatment for Tubo-Ovarian or Pelvic Abscess: A Single-Center Retrospective Cohort Study.

Gynecol Obstet Invest 2019 Jan 4:1-9. Epub 2019 Jan 4.

Background/aim: We aimed to assess the value of early laparoscopic therapy in management of tubo-ovarian abscess (TOA) or pelvic abscess.

Methods: This was a retrospective study of all consecutive patients who were initially diagnosed with TOA or pelvic abscess at the local hospital between January 2010 and December 2014. The risks of operation and recurrence were analyzed using logistic analyses. Read More

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https://www.karger.com/Article/FullText/493855
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http://dx.doi.org/10.1159/000493855DOI Listing
January 2019
3 Reads
1.251 Impact Factor

Second Trimester Serum Biomarker Screen for Fetal Aneuploidies as a Predictor of Preterm Delivery: A Population-Based Study.

Gynecol Obstet Invest 2019 Jan 2:1-8. Epub 2019 Jan 2.

Objective: To determine the association between second-trimester serum Down syndrome screening (alpha-fetoprotein [AFP] free beta-human chorionic gonadotropin [b-hCG] unconjugated estriol [uE3]) and preterm birth and to create predictive models for preterm birth.

Methods: Secondary analysis on a prospective database of pregnancies undergoing second-trimester screen with complete follow-up. The multiples of medians (MoM) of the biomarkers were compared between the group of term, preterm (< 37 weeks), early preterm (< 34 weeks), and very early preterm (< 32 weeks) delivery. Read More

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http://dx.doi.org/10.1159/000495614DOI Listing
January 2019
1 Read

Ten-Year Comparison Study of Type 1 and 2 Endometrial Cancers: Risk Factors and Outcomes.

Gynecol Obstet Invest 2019 Jan 2:1-8. Epub 2019 Jan 2.

Yale University School of Medicine, New Haven, Connecticut, USA.

Aims: To compare baseline risk factors for type 1 vs. 2 endometrial cancers and analyze these risk factors for association with overall survival and time to recurrence.

Methods: Retrospective review of 816 consecutive endometrial cancer cases was conducted with diagnosis from January 2005 to December 2010 and clinical course until 2016. Read More

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http://dx.doi.org/10.1159/000493132DOI Listing
January 2019

Over Ten-Cell Good Embryo Transfers on Day Three have Equivalent Clinical Outcomes with Those of Eight-Cell Embryos in Female Patients Aged ≤35 Years: A Retrospective Cohort Study.

Gynecol Obstet Invest 2019 Jan 2:1-7. Epub 2019 Jan 2.

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan,

Background/aim: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3.

Methods: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Read More

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http://dx.doi.org/10.1159/000495407DOI Listing
January 2019

Ulipristal Acetate before Hysteroscopic and Laparoscopic Surgery for Uterine Myomas: Help or Hindrance?

Gynecol Obstet Invest 2018 Dec 14:1-13. Epub 2018 Dec 14.

Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Background/aims: Ulipristal acetate ([UPA], Esmya®) is an orally active selective progesterone-receptor modulator that has been approved as preoperative treatment for uterine myomas. This systematic review aims to summarize the available data on surgical outcomes of patients undergoing myomectomy by hysteroscopy or by laparoscopy after preoperative treatment with UPA.

Methods: this review was performed following PRISMA guidelines and was registered in PROSPERO (CRD42018092201). Read More

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https://www.karger.com/Article/FullText/495347
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http://dx.doi.org/10.1159/000495347DOI Listing
December 2018
1 Read
1.251 Impact Factor

A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer.

Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,

Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More

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http://dx.doi.org/10.1159/000495613DOI Listing
December 2018
1 Read

Ultrasonographic Findings of Uterine Carcinosarcoma.

Gynecol Obstet Invest 2018 Nov 30:1-6. Epub 2018 Nov 30.

Department of Ultrasonic Diagnosis, Obstetrics and Gynecology Hospital, Fudan University, Shanghai,

Aims: The aim of this study was to investigate the clinical features and ultrasonographic findings of uterine carcinosarcoma (UCS).

Methods: Seventy-five patients (mean age, 58.6 years) with pathologically proven UCS who were treated at our hospital from January 2003 to December 2015 were retrospectively recruited. Read More

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https://www.karger.com/Article/FullText/481885
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http://dx.doi.org/10.1159/000481885DOI Listing
November 2018
7 Reads

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis.

Gynecol Obstet Invest 2018 Nov 23:1-9. Epub 2018 Nov 23.

Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing,

Background: This study aimed to investigate the action mechanism of β-estradiol in MCF-7 breast cancer (BC) cells.

Methods: The cell samples were sequenced using Hiseq 2000, including 2 MCF-7 controls and 2 samples treated with β-estradiol. Differentially expressed genes (DEGs) were screened using the NOISeq package in R, followed by the functions and pathways analyses using Database for Annotation, Visualization and Integrated Discovery. Read More

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https://www.karger.com/Article/FullText/487945
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http://dx.doi.org/10.1159/000487945DOI Listing
November 2018
16 Reads

Impact of Locoregional Treatment on Prognosis of de novo Stage IV Breast Cancer: A Retrospective Long-Term Study of Chinese Population.

Gynecol Obstet Invest 2018 Nov 16:1-11. Epub 2018 Nov 16.

Department of Breast Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: This study aimed to evaluate the impact of locoregional resection and radiotherapy on the prognosis of Chinese women with stage IV breast cancer.

Methods: The retrospective study included Chinese patients with de novo stage IV breast cancer in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between January 1, 2001, and December 31, 2016. The patients were classified into surgery and nonsurgery groups. Read More

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https://www.karger.com/Article/FullText/488643
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http://dx.doi.org/10.1159/000488643DOI Listing
November 2018
6 Reads

Clinical and Ultrasound Predictors of Placenta Accreta in Pregnant Women with Antepartum Diagnosis of Placenta Previa: A Multicenter Study.

Gynecol Obstet Invest 2018 Nov 16:1-6. Epub 2018 Nov 16.

Department of Obstetrics and Gynecology, Obstetrical-Gynecological Ultrasound Unit, "Sant'Anna Hospital", Turin, Italy.

Background/aims: Abnormally invasive placenta (AIP) includes placenta accreta, increta, and percreta and represents major complications of pregnancy. This study was designed to assess the role of ultrasonography in the identification of AIP among pregnant women with antepartum diagnosis of placenta previa.

Methods: A cross-sectional study was performed between May 2015 and April 2016 in 11 centers, including 242 women with antepartum diagnosis of placenta previa. Read More

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http://dx.doi.org/10.1159/000494492DOI Listing
November 2018
3 Reads

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients.

Gynecol Obstet Invest 2018 Nov 14:1-9. Epub 2018 Nov 14.

Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS).

Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). Read More

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https://www.karger.com/Article/FullText/493794
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http://dx.doi.org/10.1159/000493794DOI Listing
November 2018
10 Reads

Ovarian Clear Cell Carcinoma Detected During Long-Term Management of Endometriotic Cysts in Young Patients: Possible Heterogeneity of this Tumor.

Gynecol Obstet Invest 2018 Nov 13:1-8. Epub 2018 Nov 13.

Department of Gynecology, Toho University Ohashi Medical Center, Tokyo, Japan.

Ovarian endometriotic cysts have been identified as the possible origin of ovarian clear cell carcinoma (OCCC), so predicting or preventing future transformation is important. Early detection of clear cell carcinoma is important because it shows low sensitivity to chemotherapy and the prognosis is worse than for other histologic types. We recently treated 2 patients with OCCC. Read More

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https://www.karger.com/Article/FullText/494256
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http://dx.doi.org/10.1159/000494256DOI Listing
November 2018
14 Reads

A Non-Lethal Osteogenesis Imperfecta Type II Mutation.

Gynecol Obstet Invest 2018 Nov 8:1-5. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.

Background: We discuss the ethical decision points in a case report that describes a novel COL1A1 mutation associated to Osteogenesis Imperfecta type II, but with a non-lethal outcome.

Case: A 33-year-old female underwent a 21-week ultrasound that revealed short bowed femurs and humeri with old fractures and bowed tibias and fibulas. Amniotic fluid testing revealed a novel COL1A1 mutation (c. Read More

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https://www.karger.com/Article/FullText/494491
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http://dx.doi.org/10.1159/000494491DOI Listing
November 2018
12 Reads
1.251 Impact Factor

Chorionic Bump: An Early Ultrasound Marker for Adverse Obstetric Outcome.

Gynecol Obstet Invest 2018 Nov 2:1-5. Epub 2018 Nov 2.

Department of Obstetrics and Gynecology, Fetal Medicine Unit, Hospital Clínico Universidad de Chile, Santiago,

Backgrounds/aims: To assess the perinatal outcome of pregnancies with chorionic bump detected at the first trimester of pregnancy.

Methods: This was a nested case-control study of pregnancies with chorionic bump identified at the first trimester ultrasound that was performed from October 2014 and October 2016. The control group consisted of the following 5 unaffected pregnancies after each case. Read More

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https://www.karger.com/Article/FullText/493477
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http://dx.doi.org/10.1159/000493477DOI Listing
November 2018
17 Reads

Preliminary insights on the relation between endometriosis, pelvic pain, and employment.

Gynecol Obstet Invest 2018 Oct 31:1-6. Epub 2018 Oct 31.

Department of Clinical Sciences and Community Health, Università degli Studi, and Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Aims: The economic burden of endometriosis and pelvic pain involves direct and indirect healthcare costs due to work loss and decreased productivity. However, the relation between endometriosis, pelvic pain, and employment remains underinvestigated. This study aimed at providing preliminary insights into this topic. Read More

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https://www.karger.com/Article/FullText/494254
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http://dx.doi.org/10.1159/000494254DOI Listing
October 2018
13 Reads

Three-Dimensional Modelization of the Female Human Inferior Hypogastric Plexus: Implications for Nerve-Sparing Radical Hysterectomy.

Gynecol Obstet Invest 2018 Oct 31:1-8. Epub 2018 Oct 31.

Department of Gynecologic and Breast Oncologic Surgery, Georges Pompidou European Hospital, Paris, France.

Background/aims: This study aims to describe the autonomic nervous network of the female pelvis with a 3D model and to provide a safe plane of dissection during radical hysterectomy for cervical cancer.

Methods: Pelvises of 3 human female fetuses were studied by using the computer-assisted anatomic dissection.

Results: The superior hypogastric plexus (SHP) was located at the level of the aortic bifurcation in front of the sacral promontory and divided inferiorly and laterally into 2 hypogastric nerves (HN). Read More

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https://www.karger.com/Article/FullText/494255
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http://dx.doi.org/10.1159/000494255DOI Listing
October 2018
15 Reads

High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women.

Gynecol Obstet Invest 2018 Oct 19:1-12. Epub 2018 Oct 19.

Department of Food and Nutrition, Obesity/Diabetes Center, College of Life and Health Sciences, Hoseo University, Asan, Republic of Korea.

Background: We explored the genetic variants that were associated with polycystic ovary syndrome (PCOS) by genome-wide association study (GWAS) and evaluated the association of genetic risk scores (GRS) of the selected genetic variants with insulin resistance and the interaction of the GRS with nutrient intake to develop insulin resistance.

Methods: The 6 genetic variants involved in brain and nervous system (acid sensing ion channel subunit 2 rs8071961, rs1988598, and rs16589, macro domain containing 2 rs7262810 CHRM3 rs1867265 and chromosome 2 open reading frame 83 rs11889798) were selected from a GWAS of the PCOS study. GRS of the 6 single nucleotide polymorphisms was calculated in 3,723 Korean women in the Ansan/Ansung cohort of KARE study. Read More

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http://dx.doi.org/10.1159/000493131DOI Listing
October 2018
1 Read

Risk Factors of Intra-Amniotic Infection Related to Induction with Single-Balloon Catheter: A Case-Control Study.

Gynecol Obstet Invest 2018 Oct 17:1-7. Epub 2018 Oct 17.

Aims: To investigate the risk factors of intra-amniotic infection (IAI) related to induction with single-balloon catheter (SBC).

Methods: A retrospective, case-control study including 58 cases of IAI patients who underwent induction with SBC was conducted in Women's Hospital, School of Medicine, Zhejiang University. For each case, 8 women who delivered during the same month and had no infection after SBC induction were selected for control. Read More

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http://dx.doi.org/10.1159/000493795DOI Listing
October 2018

Clinical Impact of a Restrictive Labor Induction Approval Process.

Gynecol Obstet Invest 2018 Oct 12:1-8. Epub 2018 Oct 12.

Division of Maternal-Fetal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Background/aims: The aim of this study was to evaluate the impact of a restrictive labor induction approval process on induction and primary cesarean delivery rates.

Methods: A retrospective cohort study was conducted at a tertiary care academic center from 2006 through 2012. The cohort of deliveries before (pre-intervention) and after (post-intervention) the process included term, singleton pregnancies with no contraindication to vaginal delivery. Read More

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http://dx.doi.org/10.1159/000491084DOI Listing
October 2018

CD44+/CD24+-Expressing Cervical Cancer Cells and Radioresistant Cervical Cancer Cells Exhibit Cancer Stem Cell Characteristics.

Gynecol Obstet Invest 2018 Oct 12:1-9. Epub 2018 Oct 12.

Department of Gynecological Tumor, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Radiation therapy is a mainstay in the treatment of cervical cancer. However, most advanced and metastatic cervical cancers are resistant to radiation therapy because of the presence of cancer stem cells (CSCs). To date, no specific markers were found for cervical CSCs. Read More

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http://dx.doi.org/10.1159/000493129DOI Listing
October 2018
2 Reads

Nintedanib for Advanced Epithelial Ovarian Cancer: A Change of Perspective? Summary of Evidence from a Systematic Review.

Gynecol Obstet Invest 2018 Oct 10:1-11. Epub 2018 Oct 10.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy.

Background/aims: Epithelial ovarian cancer (EOC) is the sixth most commonly diagnosed cancer among women. Results with available therapies are far from being satisfactory and, therefore, current research is focusing on new anticancer drugs to improve the clinical response of these patients. Nintedanib is an oral multiple tyrosine kinases inhibitor, which targets angiogenesis. Read More

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https://www.karger.com/Article/FullText/493361
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http://dx.doi.org/10.1159/000493361DOI Listing
October 2018
5 Reads
1.251 Impact Factor

Effects of Sodium Hyaluronate on Symptoms and Quality of Life in Women Affected by Pregnancy Rhinitis: A Pilot Study.

Gynecol Obstet Invest 2018 Oct 3:1-7. Epub 2018 Oct 3.

Department of Surgical and Biomedical Sciences, Section of Obstetrics and Gynecology, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy.

Aims: To investigate sodium hyaluronate (SH) efficacy in the treatment of pregnancy rhinitis.

Methods: A single-center, prospective, open-label, 2 parallel-group study was carried out. Pregnant women affected by pregnancy rhinitis were randomly assigned to 1 of 2 groups: Group A was treated with SH, while Group B did not receive any treatment. Read More

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http://dx.doi.org/10.1159/000493137DOI Listing
October 2018
11 Reads

Can We Improve Vaginal Tissue Healing Using Customized Devices: 3D Printing and Biomechanical Changes in Vaginal Tissue.

Gynecol Obstet Invest 2018 Sep 28:1-9. Epub 2018 Sep 28.

Division of Pediatric Adolescent Gynecology, Baylor College of Medicine, Houston, Texas, USA.

Background: Determining biomechanical changes in vaginal tissue with tissue stretch is critical for understanding the role of mechanotransduction on vaginal tissue healing. Noncontact dynamic optical coherence elastography (OCE) can quantify biomechanical changes in vaginal tissues noninvasively. Improved vaginal tissue healing will reduce postoperative complications from vaginal surgery. Read More

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http://dx.doi.org/10.1159/000491696DOI Listing
September 2018
6 Reads

Colposcopy in Evaluating Bleeding During the Second and Third Trimesters: Short-Term and Postpartum Implications.

Gynecol Obstet Invest 2018 Sep 28:1-5. Epub 2018 Sep 28.

Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel.

Background: The etiology of vaginal bleeding during pregnancy may be obstetric or non-obstetric. Though colposcopy is generally not part of the routine evaluation of 2nd- or 3rd-trimester vaginal bleeding without obvious obstetrical cause, our department does perform colposcopy and cervical cytology testing in these patients. This study assessed the need and possible contribution of colposcopy in diagnosing the etiology of 2nd- and 3rd-trimester bleeding. Read More

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http://dx.doi.org/10.1159/000493266DOI Listing
September 2018
3 Reads

Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway.

Gynecol Obstet Invest 2018 Sep 25:1-9. Epub 2018 Sep 25.

Aim: To investigate whether long non-coding RNA (lncRNA) ZEB1 antisense 1 (ZEB1-AS1) affects cell migration and invasion of cervical cancer by regulating epithelial-mesenchymal transition (EMT) via the p38MAPK pathway.

Methods: Human cervical cancer cell line Hela was classified into Control, NC siRNA, ZEB1-AS1 siRNA, SB203580 (p38MAPK pathway inhibitor) and ZEB1-AS1 siRNA + Anisomycin (p38MAPK pathway activator) groups. Quantitative real-time polymerase chain reaction was performed for ZEB1-AS1 expression, Western blotting to measure p38MAPK signaling pathway-/EMT-related proteins, and Wound-healing and Transwell assays to evaluate cell migration and invasion respectively. Read More

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http://dx.doi.org/10.1159/000493265DOI Listing
September 2018
1 Read

Correlation of Vitamin D3 (Calcitriol) Serum Concentrations with Vitamin B12 and Folic Acid in Women Undergoing in vitro Fertilisation/Intracytoplasmatic Sperm Injection.

Gynecol Obstet Invest 2018 Sep 25:1-8. Epub 2018 Sep 25.

Background: The important role of vitamin D3 in human health is well recognized. In this study, we measured serum concentrations of vitamin D3, vitamin B12 and B9 (folic acid) in 410 women undergoing in vitro fertilisation (IVF)/intracytoplasmatic sperm injection (ICSI) with dedicated focus on 3-month changes in consideration of patients' BMI.

Methods: Patients were of European origin and did not take any supplementation of D3. Read More

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https://www.karger.com/Article/FullText/493138
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http://dx.doi.org/10.1159/000493138DOI Listing
September 2018
4 Reads

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study.

Gynecol Obstet Invest 2019 20;84(1):86-93. Epub 2018 Sep 20.

Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

Aims: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI).

Methods: A retrospective medical records review was conducted, examining patients surgically treated for endometriosis at a single center in Korea between January 2009 and February 2015. In total, 68 women attempting natural conception were analyzed by assessing age, preoperative serum CA-125, body mass index, revised American Fertility Society (rAFS) stage, EFI, and pregnancy outcome. Read More

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http://dx.doi.org/10.1159/000493264DOI Listing
September 2018
1 Read

The Female Genital Mutilation/Cutting Experience in Somali Women: Their Wishes, Knowledge and Attitude.

Gynecol Obstet Invest 2018 Sep 18:1-10. Epub 2018 Sep 18.

Department of Obstetrics and Gynecology, Somalia Mogadishu Turkey Education and Research Hospital, Mogadishu, Somalia.

Background: Female genital mutilation/cutting (FGM/C) is a common sociocultural practice in many communities in Africa. Unfortunately, what females are forced to accept because they are helpless, in order to be an individual in social life and in the country they live in, is an important health issue that is not only harmful to the human body but also against human rights.

Objectives: This study aimed to investigate the wishes, knowledge and attitude of Somali women regarding FMG/C. Read More

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https://www.karger.com/Article/FullText/493130
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http://dx.doi.org/10.1159/000493130DOI Listing
September 2018
11 Reads

Brief Report on 3-Weekly Paclitaxel Carboplatin Efficacy in Locally Advanced or Metastatic Squamous Vulvar Cancer.

Gynecol Obstet Invest 2018 18;83(6):620-626. Epub 2018 Sep 18.

Department of Obstetrics-Gynecology, Hospital of la Citadelle, Liège, Belgium.

In this brief report, we present our experience with 3-weekly paclitaxel-carboplatin chemotherapy for patients with vulvar cancer. Two patients with locally advanced disease had an impressive response allowing standard vulvar cancer surgery. One patient with metastatic disease had local stable disease though it was progressive in the lymph nodes. Read More

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https://www.karger.com/Article/FullText/487435
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http://dx.doi.org/10.1159/000487435DOI Listing
January 2019
4 Reads

Breast Cancer in Pregnancy: A Retrospective Cohort Study.

Gynecol Obstet Invest 2019 14;84(1):79-85. Epub 2018 Sep 14.

Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Gestational breast cancer (GBC) is the second most commonly occurring malignancy affecting pregnant women. Management is complex due to potential foetal risks in the setting of maternal treatment. We report on the maternal, foetal, short-term neonatal and placental histopathologic findings of a retrospective cohort of pregnant women with either pre-gestational (group 1) or GBC (group 2) from a tertiary-level maternity care centre. Read More

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https://www.karger.com/Article/FullText/493128
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September 2018
14 Reads
1.251 Impact Factor

A Randomized Controlled Trial on Efficacy and Safety of Trocar-Site Infiltration with Lidocaine for Postoperative Pain Relief after Diagnostic Laparoscopy.

Gynecol Obstet Invest 2019 24;84(1):71-78. Epub 2018 Aug 24.

Effective Care Research Unit, Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.

Background/aims: To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy.

Methods: A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institute for Endoscopy at Life Specialist Hospital, Nnewi, Nigeria. One hundred and ninety nine women were assigned at random to either trocar-site infiltration with lidocaine (n = 100) or no intervention (n = 99). Read More

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http://dx.doi.org/10.1159/000490565DOI Listing
August 2018
2 Reads
1.251 Impact Factor

Four Circulating Long Non-Coding RNAs Act as Biomarkers for Predicting Cervical Cancer.

Gynecol Obstet Invest 2018 22;83(6):533-539. Epub 2018 Aug 22.

Department of Medical Statistics, Medical College of Qinghai University, Xining, China.

Background/aims: Circulation long non-coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and might be applied for cancer diagnosis, prognosis, or potential therapeutic targets. In this study, we aimed to explore whether the circulation lncRNA could predict the tumorigenesis of surgical squamous cervical cancer (CC).

Methods: In this study, we applied the lncRNA microarray to screen the potential biomarker for CC. Read More

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http://dx.doi.org/10.1159/000487595DOI Listing
January 2019
2 Reads

A Case Series on Platelet-Rich Plasma Revolutionary Management of Poor Responder Patients.

Gynecol Obstet Invest 2019 22;84(1):99-106. Epub 2018 Aug 22.

Centre for Human Reproduction, Genesis Athens Clinic, Athens, Greece.

Poor responders are described as those In Vitro Fertilization (IVF) patients who are failing to respond to controlled ovarian stimulation protocols. Extensive research has focused on crafting the optimal treatment. However, it appears that each approach fails to be established as effective or guaranteed towards successful management. Read More

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https://www.karger.com/Article/FullText/491697
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http://dx.doi.org/10.1159/000491697DOI Listing
August 2018
44 Reads

The Utility of Feticide Procedure to Shorten the Induction-to-Abortion Interval in Medical Abortion.

Gynecol Obstet Invest 2019 10;84(1):64-70. Epub 2018 Aug 10.

Department of Obstetrics and Gynecology, Division of Perinatology, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey.

Aim: To evaluate the effect of intracardiac potassium chloride feticide procedure (FP) on the induction-to-abortion (I-to-A) interval for various indications in the termination of pregnancy.

Method: Medically indicated abortions between 17 and 28 weeks' gestation were retrospectively evaluated and allocated into 2 groups: Cases with (group 1, n = 58) or without an FP (group 2, n = 60). I-to-A intervals were compared across the groups, considering different baseline parameters and fetal abnormality categories. Read More

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http://dx.doi.org/10.1159/000491085DOI Listing
August 2018
12 Reads

Multidose Methotrexate Treatment of Ectopic Pregnancies with High initial β-Human Chorionic Gonadotropin: Can Success Be Predicted?

Gynecol Obstet Invest 2019 10;84(1):56-63. Epub 2018 Aug 10.

Fatih Sultan Mehmet Research Hospital, Clinic of Obstetrics and Gynecology, Istanbul, Turkey.

Objective: To investigate the clinical results and prognostic factors of multiple dose methotrexate (Mtx) treatment of ectopic pregnancy patients with high initial serum (human chorionic gonadotropin [hCG]).

Design: Retrospective cohort study.

Patients: Twenty-six ectopic pregnancy patients with serum (βhCG) > 5,000 mIU/mL who received multiple doses of Mtx (1 mg/kg) with folinic acid rescue on the alternating days. Read More

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http://dx.doi.org/10.1159/000491083DOI Listing
August 2018
1 Read

Gynecologic Oncologists' Perceptions of Palliative Care and Associated Barriers: A Survey of the Society of Gynecologic Oncology.

Gynecol Obstet Invest 2019 10;84(1):50-55. Epub 2018 Aug 10.

Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.

Objectives: Gynecologic oncologists frequently care for patients at the end of life with the aid of palliative care (PC) specialists. Our primary objectives were to identify perceived barriers to integrating specialty PC into gynecologic cancer care.

Materials And Methods: Members of the Society of Gynecologic Oncology (SGO) were invited to participate in an anonymous online survey. Read More

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http://dx.doi.org/10.1159/000491089DOI Listing
August 2018
14 Reads

The Role of Serum Caspase 3 Levels in Prediction of Endometriosis Severity.

Gynecol Obstet Invest 2018 2;83(6):576-585. Epub 2018 Aug 2.

Department of Obstetrics and Gynecology, University of Health Sciences, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Background/aims: To identify the role of serum caspase 3, Annexin A2 (ANXA2), and Soluble Fas Ligand (sFasL) levels in the prediction of endometriosis severity.

Methods: The study was performed on 90 women who were candidates for laparoscopic surgery due to endometrioma or any other benign ovarian cysts detected by ultrasound examination, pelvic pain, or infertility. The control group comprised 29  patients. Read More

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https://www.karger.com/Article/FullText/489494
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http://dx.doi.org/10.1159/000489494DOI Listing
January 2019
23 Reads

Correlation between the Length of Ovarian Ligament and Ovarian Torsion: A Prospective Study.

Gynecol Obstet Invest 2019 2;84(1):45-49. Epub 2018 Aug 2.

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Study Objective: The study aimed to evaluate whether there is an association between the ovarian ligament length and ovarian torsion.

Design: This is a prospective cohort study. Design Classification: II. Read More

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http://dx.doi.org/10.1159/000490664DOI Listing
August 2018
13 Reads

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome.

Gynecol Obstet Invest 2019 26;84(1):35-44. Epub 2018 Jul 26.

Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa,

Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS).

Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively investigated. All women were treated with exogenous estradiol and progesterone to simulate a normal menstrual cycle (28-day duration) after GnRH-induced pituitary desensitization. Read More

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http://dx.doi.org/10.1159/000491086DOI Listing
July 2018
9 Reads