7,359 results match your criteria Gynecologic Tumor Markers


Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh.

J Lab Physicians 2019 Jan-Mar;11(1):75-81

Department of Pathology, Homi Bhabha Cancer Hospital (A unit of Tata Memorial Centre, Mumbai), Varanasi, Uttar Pradesh, India.

Background: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India.

Materials And Methods: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Read More

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http://dx.doi.org/10.4103/JLP.JLP_117_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437827PMC
April 2019
1 Read

Mutational diversity and therapy response in breast cancer - a sequencing analysis in the neoadjuvant GeparSepto trial.

Clin Cancer Res 2019 Apr 12. Epub 2019 Apr 12.

Charité - Universitätsmedizin Berlin.

Purpose: Next-generation-sequencing (NGS) can be used for comprehensive investigation of molecular events in breast cancer (BC). We evaluated the relevance of genomic alterations for response to neoadjuvant chemotherapy (NACT) in the GeparSepto trial.

Experimental Design: 851 pretherapeutic FFPE core biopsies from GeparSepto study were sequenced. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3258DOI Listing
April 2019
1 Read

Comprehensive analysis of serum tumor markers and BRCA1/2 germline mutations in Chinese ovarian cancer patients.

Mol Genet Genomic Med 2019 Apr 10:e672. Epub 2019 Apr 10.

Sanway Gene Technology Inc., Changsha, China.

Background: The serum tumor markers has been widely used in ovarian cancer diagnosis. BRCA1/2 germline mutations are the most common predisposing factors for ovarian cancer development. This study aimed to comprehensively investigate serum tumor markers and BRCA1/2 germline mutations and analyze their associations with ovarian cancer. Read More

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http://dx.doi.org/10.1002/mgg3.672DOI Listing
April 2019
3 Reads

Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer.

Biosci Rep 2019 Apr 16;39(4). Epub 2019 Apr 16.

Cancer Care Centre, St George Hospital, Kogarah, New South Wales, Australia

Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature mRNA export as a component of TRanscription-Export complex. However, the role of CHTOP in ovarian cancer is unclear. Read More

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http://dx.doi.org/10.1042/BSR20190016DOI Listing
April 2019
1 Read
2.637 Impact Factor

Molecular markers in recurrent stage I, grade 1 endometrioid endometrial cancers.

Gynecol Oncol 2019 Mar 22. Epub 2019 Mar 22.

University of Colorado Denver Aurora, Department of Gynecologic Oncology, CO, United States of America.

Objectives: Stage I, grade 1 endometrial cancers have low recurrence rates and often do not receive adjuvant therapy. We compared recurrent cases to matched non-recurrent controls to evaluate for molecular markers associated with higher risk of recurrence.

Methods: A case-control study including all cases of recurrent stage I, grade 1 endometrioid endometrial cancer at one institution in a ten-year period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193027
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http://dx.doi.org/10.1016/j.ygyno.2019.03.100DOI Listing
March 2019
5 Reads

Update Breast Cancer 2019 Part 2 - Implementation of Novel Diagnostics and Therapeutics in Advanced Breast Cancer Patients in Clinical Practice.

Geburtshilfe Frauenheilkd 2019 Mar 12;79(3):268-280. Epub 2019 Mar 12.

Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

The treatment of patients with advanced breast cancer has developed further in recent years. In addition to therapeutic progress in the established subgroups (hormone receptor and HER2 status), there are now therapies which are geared to individual molecular characteristics, such as PARP inhibitor therapy in BRCA-mutated patients. In addition to this, tests are being developed which are intended to establish additional markers within subgroups in order to predict the efficacy of a therapy. Read More

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http://dx.doi.org/10.1055/a-0842-6661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414305PMC
March 2019
11 Reads

Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme.

Radiat Oncol 2019 Mar 4;14(1):37. Epub 2019 Mar 4.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University Toruń, Bydgoszcz, Poland.

Background: Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown.

Methods: Thirty-five patients had two scans 5-15 and 50-60 min after i. Read More

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http://dx.doi.org/10.1186/s13014-019-1241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398237PMC
March 2019
3 Reads

TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling.

J Exp Clin Cancer Res 2019 Feb 28;38(1):106. Epub 2019 Feb 28.

Hunan clinicaI research center in gynecologic cancer, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283, Tongzipo Road, Changsha, 410013, Hunan, People's Republic of China.

Background: The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechanisms underlying the action of TRPM7 in ovarian cancer are unclear. Read More

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http://dx.doi.org/10.1186/s13046-019-1061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396458PMC
February 2019
1 Read

Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium.

J Cancer Res Clin Oncol 2019 Apr 27;145(4):1063-1073. Epub 2019 Feb 27.

Department of Gynecology, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Objective: The impact of angiogenesis on long-term survival of high-grade serous ovarian cancer (HGSOC) patients remains unclear. This study investigated whether angiogenic markers correlated with 5-year progression-free survival (PFS) in a large cohort of matched advanced HGSOC tissue samples.

Methods: Tumor samples from 124 primary HGSOC patients were retrospectively collected within the Tumor Bank Ovarian Cancer ( http://www. Read More

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http://dx.doi.org/10.1007/s00432-019-02877-4DOI Listing
April 2019
2 Reads

Expression of NRP-1 and NRP-2 in Endometrial Cancer.

Curr Pharm Biotechnol 2019 Feb 19. Epub 2019 Feb 19.

Department of Histology and Embryology, Medical University of Silesia. Poland.

Background: Neuropilins (NRPs) participate in many processes related to the cancer development such as angiogenesis, lymphangiogenesis and metastasis. Although endometrial cancer is one of the most common gynecological cancers, it has not been studied in terms of NRPs expression.

Objective: The aim of this study was to investigate the potential utility of NRPs as important factors in the diagnosis and treatment of endometrial cancer. Read More

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http://dx.doi.org/10.2174/1389201020666190219121602DOI Listing
February 2019
2 Reads

A four-miRNA signature as a novel biomarker for predicting survival in endometrial cancer.

Gene 2019 May 16;697:86-93. Epub 2019 Feb 16.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China; Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address:

Background: The microRNAs (miRNAs) have been validated as prognostic markers in many cancers. The aim of this study was to identify new miRNA prognostic biomarkers in endometrial cancer (EC) and to develop an expression-based miRNA signature to provide survival risk prediction for EC patients.

Methods: From TCGA database, the miRNA datasets of EC and clinical information were downloaded in April 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193012
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http://dx.doi.org/10.1016/j.gene.2019.01.046DOI Listing
May 2019
7 Reads

Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance.

Cancer Med 2019 Mar 13;8(3):920-927. Epub 2019 Feb 13.

Department of Oncology, Division of Gynecologic Oncology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan.

Novelty and Impact Statement: Our findings suggest that soluble folate receptor (sFR) could be used in both the initial diagnosis and surveillance of patients with ovarian cancer. Our cohort constitutes one of the largest comparison groups for sFR analyzed so far. We have defined the background level of sFR using healthy volunteers. Read More

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http://dx.doi.org/10.1002/cam4.1944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434204PMC
March 2019
1 Read

Significance of serum antibodies against HPV E7, Hsp27, Hsp20 and Hp91 in Iranian HPV-exposed women.

BMC Infect Dis 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.

Background: Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer. Moreover, the levels of anti-heat shock protein (Hsp) and anti-high mobility group box-1 (HMGB1) antibodies in cancer patients have been useful in tumor diagnosis. Read More

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http://dx.doi.org/10.1186/s12879-019-3780-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373072PMC
February 2019
2.613 Impact Factor

Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis.

J Ovarian Res 2019 Feb 11;12(1):16. Epub 2019 Feb 11.

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.

Subjective: The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Method: Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. Read More

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http://dx.doi.org/10.1186/s13048-019-0491-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371536PMC
February 2019
1 Read

Association of CD31 and p53 With Survival of Ovarian Cancer Patients.

Anticancer Res 2019 Feb;39(2):567-576

Department of Pathology, Herlev-og Gentofte Hospital, University of Copenhagen, Herlev, Denmark

Background/aim: New markers for ovarian cancer are needed. This study aimed to examine the expression of tumour cell p53 and endothelial cell CD31 proteins and correlate them to clinicopathological factors.

Patients And Methods: Expression of proteins was immunohistochemically assessed using tissue sections from 585-599 ovarian cancer patients from the Danish MALOVA study. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13149DOI Listing
February 2019
12 Reads

Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma.

Medicine (Baltimore) 2019 Feb;98(5):e14076

Department of Gynecology and Obstetrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

To explore the role of hScrib in the pathogenesis of endometriosis.This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared the differences among them. Read More

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http://dx.doi.org/10.1097/MD.0000000000014076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380690PMC
February 2019
1 Read

Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.

World J Surg Oncol 2019 Jan 30;17(1):24. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, SetaTsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1565-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354361PMC
January 2019
8 Reads

Histone Deacetylase Inhibitors and Phenotypical Transformation of Cancer Cells.

Cancers (Basel) 2019 Jan 27;11(2). Epub 2019 Jan 27.

Department of Biochemistry and Molecular Biology, Medical University of Lublin, Chodzki 1 St., 20-093 Lublin, Poland.

Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have been investigated for their therapeutic potential in various clinical disorders, including hematological malignancies and solid tumors. Currently, several HDIs are already in clinical use and many more are on clinical trials. HDIs have shown efficacy to inhibit initiation and progression of cancer cells. Read More

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http://dx.doi.org/10.3390/cancers11020148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406474PMC
January 2019
3 Reads

Clinicopathological analysis of clinically occult extrapulmonary lymphangioleiomyomatosis in intra-pelvic and para-aortic lymph nodes associated with pelvic malignant tumors: A study of nine patients.

Pathol Int 2019 Jan;69(1):29-36

Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.

The clinicopathological and immunohistochemical characteristics of clinically occult extrapulmonary lymphangioleiomyomatosis in lymph nodes (LN-LAM) being dissected during surgical staging of pelvic malignancy have not been well investigated. We assessed samples from nine female patients (median age, 61). None had past or familial history of tuberous sclerosis and had LAM lesions other than LN such as lung. Read More

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http://dx.doi.org/10.1111/pin.12749DOI Listing
January 2019
2 Reads

Personalized Medicine in Gynecologic Cancer: Fact or Fiction?

Obstet Gynecol Clin North Am 2019 Mar;46(1):155-163

Department of Gynecologic Oncology, Ochsner Clinic Foundation, 2700 Napoleon Avenue, New Orleans, LA 70115, USA.

Personalized medicine in gynecologic oncology is an evolving field. In recent years, tumor profiling and large databases such as TCGA and NCI-Match have provided us with enormous amounts of molecular data. Several therapies that capitalize on novel genetic and immune discoveries including VEGF inhibitors, PARP inhibitors, and cancer vaccinations are discussed in this article. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898545183009
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http://dx.doi.org/10.1016/j.ogc.2018.09.010DOI Listing
March 2019
12 Reads

Reviewing vulvar Paget's disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE.

Int J Gynecol Cancer 2019 Jan 23. Epub 2019 Jan 23.

Division of Gynecologic Oncology, Vul.Can MDT, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Objectives: To review the published literature on vulvar Paget's disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.

Methods: MEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessment on the basis of the relevance and contribution to the selected topics. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000080DOI Listing
January 2019
5 Reads

Brain metastasis from ovarian clear cell carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14020

Department of Oncology, Xiang Ya Hospital, Central South University, China.

Rationale: Epithelial ovarian carcinoma (EOC) is the most common type of ovarian carcinoma, and the leading cause of female genital tract cancer-related deaths. However, brain metastasis (BM) of EOC is rare, with an incidence of only 1% to 2%. Ovarian clear cell carcinoma (OCCC), accounting for 5% to 25% of all EOC cases, has a poor prognosis compared with other epithelial cell type carcinomas. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0002
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http://dx.doi.org/10.1097/MD.0000000000014020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370159PMC
January 2019
6 Reads

Association of Base Excision Repair Gene hOGG1 Ser326Cys Polymorphism with Susceptibility to Cervical Squamous Cell Carcinoma and High-Risk Human Papilloma Virus Infection in a Chinese Population.

Genet Test Mol Biomarkers 2019 Feb 16;23(2):138-144. Epub 2019 Jan 16.

1 Women's Reproductive Health Key Laboratory of Zhejiang Province, School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, P.R. China.

Aim: This study investigated the association of the human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism with risk of cervical squamous cell carcinoma (CSCC) and high-risk human papilloma virus (HR-HPV) infection.

Background: The hOGG1 Ser326Cys polymorphism is reported to be correlated with the risk of several cancers. However, there are reports that have found no significant differences in the frequency of the hOGG1 Ser326Cys between cervical carcinoma patients and controls. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0150DOI Listing
February 2019
4 Reads

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells.

Oxid Med Cell Longev 2018 12;2018:6121328. Epub 2018 Dec 12.

Division of Applied Life Science (BK21 Plus), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Gyeongnam Province, Republic of Korea.

Silver nanoparticles (AgNPs) are widely used metal nanoparticles in health care industries, particularly due to its unique physical, chemical, optical, and biological properties. It is used as an antibacterial, antiviral, antifungal, and anticancer agent. Camptothecin (CPT) and its derivatives function as inhibitors of topoisomerase and as potent anticancer agents against a variety of cancers. Read More

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http://dx.doi.org/10.1155/2018/6121328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311846PMC
February 2019
1 Read

Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations.

Dis Markers 2018 17;2018:3810108. Epub 2018 Dec 17.

Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa 52242, USA.

Mutations in the "guardian of the genome" predominate in solid tumors. In addition to loss of tumor suppressor activity, a specific subset of missense mutations confers additional oncogenic properties. These "gain-of-function" (GOF) mutations portend poor prognosis across cancer types regardless of treatment. Read More

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http://dx.doi.org/10.1155/2018/3810108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311857PMC
December 2018
2 Reads

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target.

Cancer Cell Int 2019 8;19:10. Epub 2019 Jan 8.

1Obstetrics and Gynecology, University of British Columbia, Vancouver, BC Canada.

Background: Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that these cancers may be driven by MAPK pathway activation, MEK inhibitors (MEKi) are being tested in clinical trials. LGSC respond to MEKi only in a subgroup of patients, so predictive biomarkers and better therapies will be needed. Read More

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http://dx.doi.org/10.1186/s12935-019-0725-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325847PMC
January 2019
3 Reads

Proteomic Screening for Serum Biomarkers for Cervical Cancer and Their Clinical Significance.

Med Sci Monit 2019 Jan 9;25:288-297. Epub 2019 Jan 9.

Department of Clinical Medicine, Medical College of Yan'an University, Yan'an, Shaanxi, China (mainland).

BACKGROUND The present study aimed to determine serum markers for cervical cancer (CC) and to provide valuable references for clinical diagnosis and treatment. MATERIAL AND METHODS Serum samples were collected from age-matched healthy control women, and from female CC patients before and after surgery. Serum biomarkers were selected by comparing serum peptides profiles among the 3 groups by magnetic bead-based weak cation - exchange chromatography fractionation combined with matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Read More

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http://dx.doi.org/10.12659/MSM.911478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338008PMC
January 2019
3 Reads

Proteomic pattern of cervico-vaginal fluid (CVF) in an ovarian cancer diagnosis - pilot study.

Ginekol Pol 2018 ;89(12):688-694

Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Polska.

Objectives: High grade serous ovarian cancer (HGSC) is the most common type of ovarian cancer and is responsible for about 90% of ovarian cancer deaths. The diagnostic tests currently used do not increase the detection rates for ovarian cancer. There is a great necessity to develop new and non-invasive diagnostic tests for ovarian cancer (OC). Read More

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http://dx.doi.org/10.5603/GP.a2018.0116DOI Listing
January 2018
5 Reads

Expression of toll-like receptors in ovarian cancer.

J BUON 2018 Nov-Dec;23(6):1725-1731

"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Purpose: Ovarian cancer continues to be the most lethal gynecologic malignancy, with a complex tumor microenvironment (TME). We investigated the immunohistochemical (IHC) expression of toll like receptors (TLRs) 4,5,7 and 9 together with CD68 and CD 163 as markers for tumor-associated macrophages (TAM) in relation to clinicopathological data.

Methods: Data from 102 patients with serous ovarian cancer treated between 2006 and 2011 was retrospectively reviewed. Read More

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January 2019
14 Reads

Cisplatin-induced cardiotoxicity with midrange ejection fraction: A case report and review of the literature.

Medicine (Baltimore) 2018 Dec;97(52):e13807

Department of Cardiology, Peking Union Medical College Hospital, Beijing, China.

Rationale: Cisplatin monotherapy-induced cardiotoxicity is rare, and the prevalence remains unknown. It's extremely important to stop cisplatin when cardiotoxicity is considered.

Patient Concerns: A 53-year-old woman developed cervical cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000013807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314747PMC
December 2018
1 Read

Probing pathway-related modules in invasive squamous cervical cancer based on topological centrality of network strategy.

J Cancer Res Ther 2018 ;14(7):1638-1643

Department of Gynecology and Obstetrics, Jinan Maternity and Child Care Hospital, Jinan 250001, P.R. China.

Objective: Our work aimed to identify pathway-related modules and hub genes involved in invasive squamous cervical cancer (SCC) based on topological centralities analysis of networks.

Materials And Methods: To determine the functional modules changed in SCC, functional enrichment analyses were performed for differentially expressed genes (DEGs) between invasive SCC samples and normal controls. Then, co-expression network was constructed using EBcoexpress approach based on the DEGs. Read More

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http://dx.doi.org/10.4103/0973-1482.187352DOI Listing
February 2019
1 Read

Oncological markers CA-125, CA 19-9 and endometriosis.

Medicine (Baltimore) 2018 Dec;97(51):e13759

Department of Psychiatry, First Faculty of Medicine, Charles University, Prague.

The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000013759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320090PMC
December 2018
2 Reads

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer.

Head Neck 2019 Feb 14;41(2):463-478. Epub 2018 Dec 14.

Division of Medical Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient.

Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients.

Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). Read More

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http://dx.doi.org/10.1002/hed.25442DOI Listing
February 2019
3 Reads

Screening of Cervical Cancer with Self-Collected Cervical Samples and Next-Generation Sequencing.

Dis Markers 2018 14;2018:4826547. Epub 2018 Nov 14.

Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cervical cancer is the second leading cause of death in female genital malignancies. Persistent infection with high-risk HPV is closely related to cervical intraepithelial neoplasia (CIN). Wide-scale HPV screening has already been implemented in developed countries. Read More

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http://dx.doi.org/10.1155/2018/4826547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261398PMC
March 2019
1 Read

Transdifferentiations and heterogeneity in the stromal niches of uterine leiomyomas.

Rom J Morphol Embryol 2018 ;59(3):663-672

Division of Anatomy, Department 1, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Uterine leiomyomas, also known as uterine fibroids (UFs), are benign smooth muscle cells tumors, the most frequent tumors in women. Even though UFs are monoclonal tumors, they contain a heterogeneous and versatile cells population. There are scarce proofs about the processes of transdifferentiation that might occur in UFs, modify the tumor microenvironment and support blood and lymph vessels formation. Read More

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December 2018
3 Reads

Cutaneous Metastasis via Surgical Planes After Lumbar Spinal Reconstruction for Spinal Metastatic Disease.

World Neurosurg 2019 Mar 5;123:49-53. Epub 2018 Dec 5.

Division of Spine Surgery, Department of Orthopaedics, Alpert Medical School of Brown University, East Providence, Rhode Island, USA. Electronic address:

Background: Cervical squamous cell carcinoma is the second most common cancer in women worldwide and the third most common cause of female cancer mortality. It frequently metastasizes to the osseous spine and has been rarely reported to cause cutaneous metastases at gynecologic surgical scars.

Case Description: A 63-year-old woman with known metastatic cervical squamous cell carcinoma presented with a pathologic fracture of the L2 vertebra, unrelenting back pain, bilateral lower extremity weakness, and inability to ambulate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183277
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http://dx.doi.org/10.1016/j.wneu.2018.11.218DOI Listing
March 2019
19 Reads

STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway.

J Exp Clin Cancer Res 2018 Dec 5;37(1):305. Epub 2018 Dec 5.

Department of Gynecologic Oncology; Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.

Background: Cancer stem cells (CSCs) possess abilities of self-renewal and differentiation, have oncogenic potential and are regarded to be the source of cancer recurrence. However, the mechanism by which CSCs maintain their stemness remains largely unclear.

Methods: In this study, the cell line-derived ovarian CSCs (OCSCs), 3AO and Caov3, were enriched in serum-free medium (SFM). Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0977-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282299PMC
December 2018
15 Reads

Human papillomaviruses' proteins with clinical utility.

J Immunoassay Immunochem 2019 5;40(1):81-90. Epub 2018 Dec 5.

a Department of Molecular Virology , Stefan S Nicolau Institute of Virology , Bucharest , Romania.

Cervical cancer, the fourth leading cause of cancer-associated deaths among women worldwide, is associated with human papilloma virus (HPV) infection. Despite the prophylactic HPV vaccination and the implementation of cervical and HPV-based screening programs, a significant increase in cervical cancer incidence is estimated by the year 2020. Thus, further development of diagnostic tools that allow detection and risk assesment in genital HPV infection is necessary. Read More

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http://dx.doi.org/10.1080/15321819.2018.1553790DOI Listing
February 2019
1 Read

Expression of CK7 and CDKN2 in Cervical Intraepithelial Neoplasia and Correlation with Clinical Outcome.

Anticancer Res 2018 Dec;38(12):6673-6681

Gynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, Sao Paulo, Brazil.

Aim: To evaluate cyclin-dependent kinase inhibitor 2A (CDKN2A) and cytokeratin 7 (CK7) expression in cervical intraepithelial neoplasia (CIN) formalin-fixed samples.

Materials And Methods: Staining with antibody clones G175-405 for CDKN2A and OV-TL 12/30 for CK7 were evaluated and the detection of protein expressions were compared in 147 patients with CIN.

Results: Clinical follow-up of patients with CIN1 and CIN2 showed that most patients had a favorable outcome. Read More

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http://dx.doi.org/10.21873/anticanres.13035DOI Listing
December 2018
4 Reads

The impact of mammalian target of rapamycin inhibition on bone health in postmenopausal women with hormone receptor-positive advanced breast cancer receiving everolimus plus exemestane in the phase IIIb 4EVER trial.

J Bone Oncol 2019 Feb 2;14:010-10. Epub 2018 Oct 2.

Department of Oncology, Bethanien Hospital, Frankfurt am Main, Germany.

Background: Breast cancer and its treatments are associated with a detrimental effect on bone health. Here we report the results of an exploratory analysis assessing changes in levels of biomarkers of bone metabolism in patients enrolled in the phase IIIb 4EVER study.

Methods: The 4EVER trial investigated everolimus in combination with exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer. Read More

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http://dx.doi.org/10.1016/j.jbo.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263089PMC
February 2019
5 Reads

Performance of a DNA methylation marker panel using liquid-based cervical scrapes to detect cervical cancer and its precancerous stages.

BMC Cancer 2018 Dec 3;18(1):1197. Epub 2018 Dec 3.

MVZ CytoMol, Berner Str. 76, Frankfurt, Germany.

Background: A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, however, an essential prerequisite in such a setting to avoid overtreatment and higher screening costs.

Results: In this study, a series of cervical scrapes collected in PreservCyt liquid-based cytology (LBC) medium from women with cervical cancer (n = 5), cervical intraepithelial neoplasia grade 1-3 (n = 74), and normal cytology (n = 201; further n = 352 collected in SureThin®) were assessed for methylation of the marker regions ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 using the GynTect assay and compared to cobas® HPV and CINtec Plus® biomarker results. Read More

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http://dx.doi.org/10.1186/s12885-018-5125-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276155PMC
December 2018
1 Read

Management of placental site trophoblastic tumor: Two case reports.

Medicine (Baltimore) 2018 Nov;97(48):e13439

Interdisciplinary Department of Medicine, Gynecology and Obstetrics Clinic, University of Bari.

Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3. Read More

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http://dx.doi.org/10.1097/MD.0000000000013439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283185PMC
November 2018
18 Reads

Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13418

Department of Gynecology.

Rationale: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE.

Patient Concerns: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. Read More

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http://dx.doi.org/10.1097/MD.0000000000013418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283105PMC
November 2018
3 Reads
5.723 Impact Factor

Diagnostic Value of a Group of MicroRNA Genes Hypermethylated in Ovarian Carcinoma.

Bull Exp Biol Med 2018 Dec 28;166(2):253-256. Epub 2018 Nov 28.

N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russian Federation, Moscow, Russia.

The study was designed to determine genes of microRNAs hypermethylated in malignant ovarian tumors and to select new diagnostic and prognostic markers of the disease and effective system of markers. Using methyl-specific PCR and a representative sample of 54 ovarian cancer specimens, we determined 5 microRNA genes (MIR-34b/c, MIR-9-1, MIR-124-3, MIR-129-2, and MIR-107) hypermethylated in the majority of tumor samples in comparison with paired samples of histologically unchanged tissue (48-57% vs. 4-19%, p<0. Read More

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http://dx.doi.org/10.1007/s10517-018-4326-0DOI Listing
December 2018
2 Reads

FDG PET/CT as a survival prognostic factor in patients with advanced renal cell carcinoma.

Clin Exp Med 2019 Feb 28;19(1):143-148. Epub 2018 Nov 28.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.

Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be a marker of the biological characteristics of the tumor. In this paper, we assess FDG PET/CT as a survival prognostic marker in patients with advanced RCC. Read More

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http://link.springer.com/10.1007/s10238-018-0539-9
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http://dx.doi.org/10.1007/s10238-018-0539-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394561PMC
February 2019
14 Reads

Expression Profile of Endoglin in Different Grades of Endometrial Cancer.

Curr Pharm Biotechnol 2018 ;19(12):990-995

Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialist Hospital, Krakow, Poland.

Background: Endoglin is a marker of active, proliferating endothelial cells of blood vessels. In many cancers, it is present in both peripheral vessels and vessels located inside the tumor. Endoglin is more specific and sensitive compared to other tumor angiogenesis markers. Read More

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http://dx.doi.org/10.2174/1389201020666181127152605DOI Listing
March 2019
15 Reads

Identification and validation of potential prognostic and predictive miRNAs of epithelial ovarian cancer.

PLoS One 2018 26;13(11):e0207319. Epub 2018 Nov 26.

Department of Pathology, Molecular unit, Danish CancerBiobank, Herlev University Hospital, Herlev, Denmark.

Background: Ovarian cancer is the leading cause of death by gynecologic cancers in the Western world. The aim of the study was to identify microRNAs (miRNAs) associated with prognosis and/or resistance to chemotherapy among patients with epithelial ovarian cancer.

Methods: Using information from the Pelvic Mass Study we identified a cohort of women with epithelial ovarian cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207319PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261038PMC
April 2019
3 Reads

A prospective cohort study to evaluate immunosuppressive cytokines as predictors of viral persistence and progression to pre-malignant lesion in the cervix in women infected with HR-HPV: study protocol.

BMC Infect Dis 2018 Nov 19;18(1):582. Epub 2018 Nov 19.

Chronic Infectious Diseases and Cancer Division, Center for Research on Infectious Diseases, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Morelos, Mexico.

Background: Cervical cancer (CC) is caused by a persistent infection of high-risk human papillomavirus (HR-HPV). While most HPV infections are transient, persistent HPV infections are a significant health problem in Mexico. With an estimated HPV prevalence of 10% among women in reproductive age, approximately 25% of these women present at least a positive result in triage test, which according to previous studies is expected to be confirmed as positive CIN-2/3. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3490-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245844PMC
November 2018
16 Reads

Genome-wide characterization of aberrant DNA methylation patterns and the potential clinical implications in patients with endometrial cancer.

Pathol Res Pract 2019 Jan 11;215(1):137-143. Epub 2018 Nov 11.

Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, 150081 Harbin, China. Electronic address:

Aberrant DNA methylation has been implicated in the development of the majority of human cancers. However, the association of aberrant DNA methylation with the clinical characteristics of uterine corpus endometrial carcinoma (UCEC) has not been fully explored. We performed an integrative analysis in order to examine the genome-wide DNA methylation profile and the gene expression profile of 432 UCEC samples and 46 normal tissue samples. Read More

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http://dx.doi.org/10.1016/j.prp.2018.11.002DOI Listing
January 2019

Breast metastasis two years after pelvic surgery and adjuvant chemotherapy for serous ovarian cancer.

Gynecol Endocrinol 2019 Mar 19;35(3):211-213. Epub 2018 Nov 19.

a Department of Neuroscience, Reproductive Sciences and Dentistry , University of Naples Federico II , Naples , Italy.

Ovarian cancer is considered the leading cause of death among gynecologic neoplasias. Breast metastases from primary ovarian cancer have been reported in only 0.03-0. Read More

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http://dx.doi.org/10.1080/09513590.2018.1521795DOI Listing
March 2019
17 Reads