7,772 results match your criteria Gynecologic Tumor Markers


Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer.

Aging (Albany NY) 2020 May 28;12(10):9658-9685. Epub 2020 May 28.

Department of Gynecology and Obstetrics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China.

Background: Prostaglandin I2 synthase (PTGIS) is a crucial gene for the synthesis of prostaglandin I2, which has multiple roles in inflammation and immune modulation. However, studies on the prognostic value of PTGIS and its correlation with tumor-infiltrating immune cells in multiple cancers are still rare.

Results: Multiple datasets of the Oncomine database showed that PTGIS was expressed at low levels in lung cancer and ovarian cancer compared to the levels in normal tissues. Read More

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http://dx.doi.org/10.18632/aging.103235DOI Listing

Integrated analysis of lymphocyte infiltration-associated lncRNA for ovarian cancer via TCGA, GTEx and GEO datasets.

PeerJ 2020 7;8:e8961. Epub 2020 May 7.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Background: Abnormal expression of long non-coding RNAs (lncRNA) play a significant role in the incidence and progression of high-grade serous ovarian cancer (HGSOC), which is a leading cause of mortality among gynecologic malignant tumor patients. In this study, our aim is to identify lncRNA-associated competing endogenous RNA (ceRNA ) axes that could define more reliable prognostic parameters of HGSOC, and to investigate the lncRNAs' potential mechanism of in lymphocyte infiltration.

Methods: The RNA-seq and miRNA expression profiles were downloaded from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database; while for obtaining the differentially expressed lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs), we used edgeR, limma and DESeq2. Read More

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http://dx.doi.org/10.7717/peerj.8961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211406PMC

Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles.

Cell Oncol (Dordr) 2020 May 16. Epub 2020 May 16.

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Ovarian cancer is the most lethal gynecologic cancer and the fifth leading cause of cancer-related mortality in women worldwide. Despite various attempts to improve the diagnosis and therapy of ovarian cancer patients, the survival rate for these patients is still dismal, mainly because most of them are diagnosed at a late stage. Up to 90% of ovarian cancers arise from neoplastic transformation of ovarian surface epithelial cells, and are usually referred to as epithelial ovarian cancer (EOC). Read More

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http://dx.doi.org/10.1007/s13402-020-00513-9DOI Listing

Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study.

PLoS Med 2020 May 15;17(5):e1003111. Epub 2020 May 15.

Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical decision-making. Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer, and although several biomarkers are related to LNM, none of them are incorporated in clinical practice. The aim of this study was to develop and externally validate a preoperative BN to predict LNM and outcome in endometrial cancer patients. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228042PMC

The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer.

Mol Med 2020 May 6;26(1):39. Epub 2020 May 6.

Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.

Background: Ovarian cancer is the most lethal gynecologic cancer. Chemoresistance, especially platinum-resistance, is closely related to metastasis of ovarian cancer, however, the molecular basis by which links chemoresistance and metastasis remains vague. Disordered arachidonic acid (AA) metabolism has been shown to play an important role in the advanced ovarian cancer. Read More

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http://dx.doi.org/10.1186/s10020-020-00174-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201572PMC
May 2020
4.508 Impact Factor

[Hepatic metastases after cervical cancer surgery: clinical analysis of 13 cases].

Zhonghua Fu Chan Ke Za Zhi 2020 Apr;55(4):266-272

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhengzhou University, Cervical Disease Prevention and Treatment Engineering Center of Henan Province, Zhengzhou 450000, China.

To investigate the clinical characteristics of patients with hepatic metastasis after cervical cancer operation, and analyze the risk factors and prognostic factors of hepatic metastasis. A total of 1 312 patients with stage Ⅰa2-Ⅱb2 cervical cancer received radical surgery from January 2013 to January 2016 in the First Affiliated Hospital of Zhengzhou University were collected, of which 13 cases (0.99%, 13/1 312) had hepatic metastasis after operation. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20200114-00033DOI Listing

Smooth muscle tumor of uncertain malignant potential (STUMP): a clinicopathologic analysis of 26 cases.

Int J Clin Exp Pathol 2020 1;13(4):818-826. Epub 2020 Apr 1.

Department of Pathology, Mindong Hospital of Fujian Medical University Fu'an, Fujian, China.

Background: To investigate the clinicopathologic features, differential diagnosis, and factors associated with recurrence in patients with smooth muscle tumors of uncertain malignant potential (STUMP).

Methods: The clinical and pathologic data of STUMP patients diagnosed in Mindong Hospital of Ningde City from 2017 to 2018 were collected and slides reviewed, the high-frequency color Doppler ultrasound and pathological characteristics were observed, and the literature was reviewed.

Results: All the STUMP diagnoses were confirmed by slide review. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191150PMC

ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19.

Aging (Albany NY) 2020 Apr 27;12(8):6518-6535. Epub 2020 Apr 27.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear. We analyzed the expression levels of ACE2 in the Oncomine and TIMER databases, the correlation between ACE2 and overall survival in the PrognoScan, GEPIA and Kaplan-Meier plotter databases. The correlation between ACE2 and immune infiltration level and the type markers of immune cells was investigated in TIMER database. Read More

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http://dx.doi.org/10.18632/aging.103100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202533PMC
April 2020
6.432 Impact Factor

Efficient isolation, culture, purification, and stem cell expression profiles of primary tumor cells derived from uterine cervical squamous cell carcinoma.

Am J Reprod Immunol 2020 Apr 21:e13251. Epub 2020 Apr 21.

Department of Gynecologic Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Problem: Since not too many human uterus cervical squamous cell carcinoma (CSCC) cell lines in existence, efficient isolation, culture, and purification protocols for primary CSCC cells were optimized as a tool for the study of uterus CSCC.

Method Of Study: The protocols for partial multiple enzymatic digestion and explant cell culture were combined and then the resulting mixed cell component cultures were purified by magnetic-activated cell sorting. Colony-forming assay was utilized for detection of cell carcinogenesis potential, and immunofluorescence was used to detect protein expression of CSCC. Read More

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http://dx.doi.org/10.1111/aji.13251DOI Listing

Early diagnosis and treatment challenges of endodermal sinus tumors: A case report.

Case Rep Womens Health 2020 Jul 3;27:e00198. Epub 2020 Apr 3.

Division of Gynecologic Oncology, University of Cincinnati, Cincinnati, OH, United States.

Background: Ovarian endodermal sinus tumors (ESTs) are rapidly growing and highly malignant tumors that respond well to chemotherapy. They can be difficult to diagnose and delayed diagnosis can worsen prognosis.

Case: We present the case of a 20-year-old woman with an EST initially misdiagnosed as a tubo-ovarian abscess who then experienced rapid progression within weeks of initial presentation and was subsequently found to have unresectable advanced stage disease. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152713PMC

Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies.

Cancers (Basel) 2020 Apr 13;12(4). Epub 2020 Apr 13.

Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, USA.

Gynecologic cancers cause over 600,000 deaths annually in women worldwide. The development of chemoresistance after initial rounds of chemotherapy contributes to tumor relapse and death due to gynecologic malignancies. In this regard, cancer stem cells (CSCs), a subpopulation of stem cells with the ability to undergo self-renewal and clonal evolution, play a key role in tumor progression and drug resistance. Read More

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http://dx.doi.org/10.3390/cancers12040961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225959PMC

Role of M1-polarized tumor-associated macrophages in the prognosis of advanced ovarian cancer patients.

Sci Rep 2020 Apr 8;10(1):6096. Epub 2020 Apr 8.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

The identification of prognostic and predictive markers is crucial for choosing the most appropriate management method for ovarian cancer patients. We aimed to assess the prognostic role of tumor-associated macrophage (TAM) polarization in advanced ovarian cancer patients. We carried out a prospective observational study that included 140 consecutive patients with advanced-stage high-grade serous ovarian cancer as well as patients with other histotypes of ovarian cancer and patients with ovarian metastasis from other sites between June 2013 and December 2018. Read More

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http://dx.doi.org/10.1038/s41598-020-63276-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142107PMC

Gynecologic cancer in pregnancy.

Gynecol Oncol 2020 Apr 5. Epub 2020 Apr 5.

Division of Gynecologic Oncology, University of California, Irvine Medical Center, Orange, CA, USA. Electronic address:

Cancer complicates 1 in 1000 pregnancies. Multidisciplinary consensus comprised of Gynecologic Oncology, Pathology, Neonatology, Radiology, Anesthesiology, Maternal Fetal Medicine, and Social Work should be convened. Pregnancy provides an opportunity for cervical cancer screening, with deliberate delays in treatment permissible for early stage carcinoma. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.03.015DOI Listing

Clinical utility and value contribution of an MRI-positive line marker for image-guided brachytherapy in gynecologic malignancies.

Brachytherapy 2020 May - Jun;19(3):305-315. Epub 2020 Apr 4.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Purpose: The purpose of this study was to investigate the utility of a novel MRI-positive line marker, composed of C4:S (cobalt chloride-based contrast agent) encapsulated in high-density polyethylene tubing, in permitting dosimetry and treatment planning directly on MRI.

Methods And Materials: We evaluated the clinical feasibility of the C4:S line markers in nine sequential brachytherapy procedures for gynecologic malignancies, including six tandem-and-ovoid and three interstitial cases. We then quantified the internal resource utilization of an intraoperative MRI-guided procedural episode via time-driven activity-based costing, identifying opportunities for cost-containment with use of the C4:S line markers. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.12.005DOI Listing
April 2020
1.987 Impact Factor

Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils.

Cancer Immunol Res 2020 Jun 1;8(6):819-828. Epub 2020 Apr 1.

Department of Internal Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Myeloid derived suppressor cells (MDSC) are a heterogeneous group of immature cells that accumulate in the peripheral blood and tumor microenvironment and are barriers to cancer therapy. MDSCs serve as prognostic biomarkers and are targets for therapy. On the basis of surface markers, three subsets of MDSCs have been defined in humans: granulocytic, monocytic, and early stage (e-MDSC). Read More

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269807PMC

Flow Cytometry Characterization of Pluripotent Transmembrane Glycoproteins on Resident Cervix Uteri Cells in Patients Screened for Cervical Cancer.

Cancer Invest 2020 Apr 13;38(4):228-239. Epub 2020 Apr 13.

Department of Advanced Medical and Surgical Sciences. U.O.C. Division of Clinical Immunology, Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), University of Campania "Luigi Vanvitelli", Naples, Italy.

The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in cells could be a promising therapeutic target. Read More

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http://dx.doi.org/10.1080/07357907.2020.1742349DOI Listing

The effect of the peritoneal tumor microenvironment on invasion of peritoneal metastases of high-grade serous ovarian cancer and the impact of NEOADJUVANT chemotherapy.

Virchows Arch 2020 Mar 16. Epub 2020 Mar 16.

Division of Diagnostic Oncology & Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Peritoneal metastases of high-grade serous ovarian cancer (HGSOC) are small-sized deposits with superficial growth toward the peritoneal cavity. It is unknown whether integrity of the peritoneal elastic lamina (PEL) correlates with the peritoneal tumor microenvironment (pTME) and whether neoadjuvant chemotherapy (NACT) affects the pTME. We explored integrity of PEL, composition of pTME, effects of NACT, and the prognostic implications in patients with extensive peritoneal metastases of HGSOC. Read More

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http://dx.doi.org/10.1007/s00428-020-02795-8DOI Listing

HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.

BMC Cancer 2020 Mar 16;20(1):222. Epub 2020 Mar 16.

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Background: Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear.

Methods: The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. Read More

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http://dx.doi.org/10.1186/s12885-020-06725-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077141PMC

RNA Immune Signatures from Pan-Cancer Analysis Are Prognostic for High-Grade Serous Ovarian Cancer and Other Female Cancers.

Cancers (Basel) 2020 Mar 7;12(3). Epub 2020 Mar 7.

Department of Cancer Pharmacology, Levine Cancer Institute, Carolinas Medical Center, 1021 Morehead Medical Drive, Charlotte, NC 28204, USA.

Immune cell infiltrates within the tumor microenvironment can influence treatment response and outcome in several cancers. In this study, we developed RNA-based immune signatures from pan-cancer analysis that could serve as potential markers across tumor types and tested them for association with outcome in high-grade serous ovarian cancer (HGSOC) and other female cancers. Pan-cancer RNA-Seq cluster analysis of immune-related gene expression profiles in The Cancer Genome Atlas (TCGA) from 29 different solid tumors (4446 specimens) identified distinct but concordant gene signatures. Read More

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http://dx.doi.org/10.3390/cancers12030620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139955PMC

Looking past PD-L1: expression of immune checkpoint TIM-3 and its ligand galectin-9 in cervical and vulvar squamous neoplasia.

Mod Pathol 2020 Mar 6. Epub 2020 Mar 6.

Department of Pathology, University of Virginia, Charlottesville, VA, USA.

Immunotherapies targeting the PD-1/PD-L1 pathway have shown some success in cervical and vulvar squamous cell carcinomas, but little is known about the potential vulnerability of these tumors to other checkpoint inhibitors. TIM-3 is a checkpoint molecule that exerts immunosuppressive function via its interaction with Gal-9. TIM-3 and Gal-9 have been identified on a variety of malignancies but have not been studied in cervical and vulvar cancers, nor has their relationship to PD-L1 been established. Read More

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http://dx.doi.org/10.1038/s41379-019-0433-3DOI Listing

Could Mismatch Repair Status Serve as a Biomarker for Immunotherapy in Endometrial Carcinoma?

Anticancer Res 2020 Mar;40(3):1669-1676

First Pathology Department, National and Kapodistrian University of Athens, Athens, Greece.

Aim: To study whether mismatch repair (MMR) status is related to the expression of programmed cell death-ligand 1 (PD-L1) and CD8 counts in a series of grade 3 endometrial carcinomas.

Materials And Methods: The expression of MMR protein PD-L1 and CD8 cell count were evaluated by immunohistochemistry and related to several clinicopathological parameters.

Results: Among 105 endometrial carcinomas, 40% were of endometrioid and 60% of non-endometrioid histology. Read More

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http://dx.doi.org/10.21873/anticanres.14118DOI Listing

cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer.

Stem Cells 2020 Apr 26;38(4):487-503. Epub 2020 Feb 26.

Department of Tumor Cell Biology, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.

Cervical cancer stem cells (CCSCs) are considered major causes of chemoresistance/radioresistance and metastasis. Although several cell surface antigens have been identified in CCSCs, these markers vary among tumors because of CSC heterogeneity. However, whether these markers specifically distinguish CCSCs with different functions is unclear. Read More

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http://dx.doi.org/10.1002/stem.3157DOI Listing

Accuracy in Referrals to Gynecologic Oncologists Based on Clinical Presentation for Ovarian Mass.

Diagnostics (Basel) 2020 Feb 16;10(2). Epub 2020 Feb 16.

Capital Health Surgical Group, Gynecology Oncology, Pennington, NJ 08534, USA.

Ovarian cancer is one of the most lethal gynecological cancers in women due to late diagnosis. Despite technological advancements, experienced physicians have high sensitivities and specificities in subjective assessments when combining ultrasound findings and clinical history in analyzing adnexal masses. This study aims to demonstrate general obstetricians and gynecologists' (OB/GYN) appropriateness in gynecologic oncologist referrals for malignant ovarian masses based on history and physical (H&P), imaging, and available tumor markers. Read More

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http://dx.doi.org/10.3390/diagnostics10020106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168930PMC
February 2020

Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients.

Cancers (Basel) 2020 Feb 13;12(2). Epub 2020 Feb 13.

Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Circulating tumor cells (CTCs) are promising tools for risk prediction and the monitoring of response to therapy in cancer patients. Within the EU/IMI CANCER-ID consortium, we validated CTC enrichment systems for future inclusion into clinical trials. Due to the known heterogeneity of markers expressed on CTCs, we tested the Parsortix system (ANGLE plc) which enables label-independent CTC enrichment from whole blood based on increased size and deformability of these tumor cells compared to leukocytes. Read More

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http://dx.doi.org/10.3390/cancers12020442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072175PMC
February 2020

Proteogenomic Characterization of Endometrial Carcinoma.

Cell 2020 Feb 13;180(4):729-748.e26. Epub 2020 Feb 13.

Institute for Systems Genetics, NYU School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA. Electronic address:

We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. Read More

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http://dx.doi.org/10.1016/j.cell.2020.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233456PMC
February 2020
32.242 Impact Factor

Precursor lesions of vulvar squamous cell carcinoma - histology and biomarkers: A systematic review.

Crit Rev Oncol Hematol 2020 Mar 15;147:102866. Epub 2020 Jan 15.

Department of Pathology, Erasmus MC, University Medical Centre Rotterdam, the Netherlands. Electronic address:

The precursor lesion of vulvar squamous cell carcinoma (VSCC), namely vulvar intraepithelial neoplasia (VIN), is classified as: human papillomavirus (HPV)-related high grade squamous intraepithelial lesion (HSIL), and HPV-independent differentiated VIN (dVIN). Traditionally, histology and immunohistochemistry (IHC) have been the basis of diagnosis and classification of VIN. HSIL shows conspicuous histological atypia, and positivity on p16-IHC, whereas dVIN shows less obvious histological atypia, and overexpression or null-pattern on p53-IHC. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102866DOI Listing

CD4/CD8 ratio is a prognostic factor in IgG nonresponders among peptide vaccine-treated ovarian cancer patients.

Cancer Sci 2020 Apr 6;111(4):1124-1131. Epub 2020 Mar 6.

Cancer Vaccine Development Division, Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan.

The identification of useful biomarkers is an urgent issue in cancer treatment, particularly for immunotherapy, as only some patients experience benefits from this treatment. The early induction of the IgG response has been reported as a useful biomarker of favorable prognosis for cancer patients treated with a personalized peptide vaccination, but a portion of these patients (IgG nonresponders) fail to achieve an early induction of IgG response yet experience long-term survival. It is thus necessary to identify other biomarkers of favorable prognosis among these patients. Read More

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http://dx.doi.org/10.1111/cas.14349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156874PMC

SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.

J Gynecol Oncol 2020 Jan 21. Epub 2020 Jan 21.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

Objective: As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer.

Methods: In this study, ovarian cancer stem cells (OCSCs) induced from cell line 3AO and A2780 were enriched in serum-free medium (SFM). The effect of SURF4 on CSC-like properties was evaluated by sphere-forming assays, re-differentiation assays, quantitative real-time polymerase chain reaction, flow cytometry, Western blotting, cell viability assays and in vivo xenograft experiments. Read More

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http://dx.doi.org/10.3802/jgo.2020.31.e46DOI Listing
January 2020

miR-520b Promotes Breast Cancer Stemness Through Hippo/YAP Signaling Pathway.

Onco Targets Ther 2019 31;12:11691-11700. Epub 2019 Dec 31.

Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China.

Introduction: The breast cancer stem cells contribute to the initiation, progression, recurrence, metastasis as well as resistance of breast cancer. However, the mechanisms underlying the maintenance of breast cancer stemness have not been fully understood.

Materials And Methods: TCGA and GEO data were used for measuring miR-520b expression in breast cancer tissues. Read More

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http://dx.doi.org/10.2147/OTT.S236607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942529PMC
December 2019
1.342 Impact Factor

NTRK Fusion Cervical Sarcoma: A Report of 3 Cases, Emphasizing Morphological and Immunohistochemical Distinction from Other Uterine Sarcomas, including Adenosarcoma.

Histopathology 2020 Jan 23. Epub 2020 Jan 23.

Pathology Department, University of California, San Francisco.

Aims: A unique fibrosarcoma-like tumor of the uterine cervix harboring a rearrangement of a neurotrophic tyrosine kinase receptor gene (NTRK1 or NTRK3) has recently been described in 11 young women, some with recurrence and/or metastasis. To expand the morphological spectrum of this tumor we report three additional cases which exhibited adenosarcoma-like features not previously described, one of which is the first reported to respond to targeted therapy. We also evaluated 19 conventional uterine adenosarcomas for evidence of NTRK rearrangement. Read More

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http://dx.doi.org/10.1111/his.14069DOI Listing
January 2020

New strategies in ovarian cancer treatment.

Cancer 2019 12;125 Suppl 24:4623-4629

Gynecologic Cancer Therapeutics, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.

Insights from basic science dissecting carcinogenesis in the fallopian tube and ovary have led to a deeper understanding of the origin, molecular characteristics, and types of ovarian cancers. This logically then has led to the development of novel approaches to treat ovarian cancer. Increasingly, novel agents are being developed to target the different growth pathways. Read More

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http://dx.doi.org/10.1002/cncr.32544DOI Listing
December 2019

Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.

Medicina (Kaunas) 2020 Jan 18;56(1). Epub 2020 Jan 18.

EXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. Read More

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http://dx.doi.org/10.3390/medicina56010037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022544PMC
January 2020
0.508 Impact Factor

Multifocal perivascular epithelioid cell tumor of the uterus: report of one case and literature review.

Int J Clin Exp Pathol 2019 1;12(11):4113-4118. Epub 2019 Nov 1.

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College Bengbu, Anhui Province, China.

Background: The tumor with perivascular epithelioid cells (PEComa) is a rare mesenchymal tumor originating from a perivascular epithelioid cell line. The uterus is the most common location of PEComa, but multifocal lesions are rare. This study aimed to analyze the clinicopathologic and histochemical characteristics of uterine PEComa. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949796PMC
November 2019

Immunophenotype analysis using CLDN18, CDH17, and PAX8 for the subcategorization of endocervical adenocarcinomas in situ: gastric-type, intestinal-type, gastrointestinal-type, and Müllerian-type.

Virchows Arch 2020 Apr 13;476(4):499-510. Epub 2020 Jan 13.

Department of Clinical Laboratory Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

A classification system for invasive endocervical adenocarcinoma (ECA) focusing on high-risk human papillomavirus (HPV) detection has been recently developed. However, precursor lesions of each ECA subtype and immunohistochemical markers that effectively subcategorize ECAs with gastric and intestinal differentiation have not been fully described. Here, we aimed to subcategorize endocervical adenocarcinoma in situ (AIS) by immunophenotype and to characterize the histopathology of each AIS subtype. Read More

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http://dx.doi.org/10.1007/s00428-019-02739-xDOI Listing

E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer.

Int J Biol Sci 2020 1;16(2):320-329. Epub 2020 Jan 1.

Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea.

The transcription factor E2F is an important modulator of the cell cycle, and the unrestricted activation of E2F-dependent transcription is considered to be an important driver of tumor formation and progression. E2F8 is known to play an important role in embryonic development and cell cycle control by inhibiting E2F1. However, it is not yet known whether E2F8 is involved in the progression of cervical cancer. Read More

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http://dx.doi.org/10.7150/ijbs.37686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949145PMC
January 2020

Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma.

J Cancer Res Clin Oncol 2020 Apr 11;146(4):971-983. Epub 2020 Jan 11.

Department of Obstetrics and Gynecology, Technical University Munich, Munich, Germany.

Purpose: Endometrial mesonephric-like adenocarcinoma (ML-AC) represents a recently recognized subtype of endometrial adenocarcinoma (AC) associated with a subtle immunophenotype with a characteristic KRAS-mutation. Detailed clinico-pathologic analyses and prognostic data on ML-AC are limited.

Methods: We report a series of four cases with histopathological, immunohistochemical, and molecular analyses. Read More

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http://dx.doi.org/10.1007/s00432-019-03123-7DOI Listing

Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway.

Chemosphere 2020 May 31;246:125775. Epub 2019 Dec 31.

Weifang Medical University, Weifang, 261053, China; Weihai Key Laboratory of Autoimmunity, Weihai Central Hospital, Weihai, 264400, China. Electronic address:

Cancer stem cells (CSCs) are a very small subpopulation that have stem-cell qualities, such as exhibiting self-renewal, immortality, and pluripotency, and the capability to differentiate into different tumor cell subtypes. CSCs contribute to tumor onset, expansion, metastasis, resistance and recurrence. Meanwhile, organic pollutants, including nonpersistent pollutants, such as bisphenol A (BPA), and persistent pollutants, such as polychlorinated biphenyls (PCBs), are toxic chemicals that can be readily ingested via dietary exposure and other exposure routes and can accumulate through the food chain. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.125775DOI Listing
May 2020
3.340 Impact Factor

Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer.

PLoS One 2020 9;15(1):e0227707. Epub 2020 Jan 9.

Department of Medical Microbiology, Immunology and Cell Biology, SIU School of Medicine, Springfield, Illinois, United States of America.

Epithelial ovarian cancer (OC) is the most deadly cancer of the female reproductive system. To date, there is no effective screening method for early detection of OC and current diagnostic armamentarium may include sonographic grading of the tumor and analyzing serum levels of tumor markers, Cancer Antigen 125 (CA-125) and Human epididymis protein 4 (HE4). Microorganisms (bacterial, archaeal, and fungal cells) residing in mucosal tissues including the gastrointestinal and urogenital tracts can be altered by different disease states, and these shifts in microbial dynamics may help to diagnose disease states. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227707PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952086PMC

Neutrophil-to-lymphocyte ratio and platelet count as prognostic factors in ovarian malignancies.

J Cancer Res Ther 2019 Oct-Dec;15(6):1226-1230

Department of Maternal-Child, Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Minas Gerais State, Uberaba-MG, Brazil.

Objective: The objectives of the present study were to demonstrate the influence of neutrophils, platelets, and neutrophil-lymphocyte ratio (NLR) in the ovarian cancer prognosis and to compare these parameters with benign ovarian neoplasms.

Materials And Methods: Records of patients underwent surgery for ovarian cysts were evaluated. There were 72 malignant neoplasms and 213 benign neoplasms. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_304_17DOI Listing

TLR9 EXPRESSION, LANGERHANS CELL DENSITY AND LYMPHOCYTIC INFILTRATION IN PROGRESSING CERVICAL INTRAEPITHELIAL NEOPLASIA.

Georgian Med News 2019 Nov(296):126-130

Tbilisi State Medical University, Georgia.

Toll like receptors (TLRs), NK cells, Langerhans cells and T cells play an important role in the protection of host organism from human papilloma virus (HPV) infection. The aim of our study was to analyse TLR9 expression, Langerhans cell density and NK cell and Lymphocytic infiltration in the progression of cervical intraepithelial neoplasia (CIN). By using standard immunohistochemistry, we have investigated TLR9, CD1a Langerhans cell marker, CD56 NK cell marker, CD3 general T cell marker, CD4 T helper cell marker and CD8 cytotoxic T cell marker. Read More

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November 2019

Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis?

BMC Womens Health 2019 12 30;19(1):169. Epub 2019 Dec 30.

Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang, 310006, People's Republic of China.

Background: Endometriosis is defined as a chronic inflammatory disease. Recent studies have shown that increased coagulation parameters including fibrinogen and platelets are associated with endometriosis. The objective of this study was to determine the levels of inflammatory markers and coagulation parameters and their correlations in women with endometriomas compared to those with benign ovarian cysts or normal pelvic anatomy. Read More

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http://dx.doi.org/10.1186/s12905-019-0860-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937785PMC
December 2019

Immune checkpoint expression, microsatellite instability, and mutational burden: Identifying immune biomarker phenotypes in uterine cancer.

Gynecol Oncol 2020 02 24;156(2):393-399. Epub 2019 Dec 24.

Wayne State University, Detroit, MI, USA.

Objectives: Increasing grade of endometrioid endometrial cancer (EEC) is associated with aggressive behavior and poor prognosis. The traditional classification system is limited in its ability to guide treatment planning and prognostication. We identify distinct immune biomarker phenotypes using known markers of immunogenicity to identify patients who may benefit from immune therapy (IT). Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.11.035DOI Listing
February 2020

Comparison of salvage therapies for isolated para-aortic lymph node recurrence in patients with uterine cervical cancer after definitive treatment.

Radiat Oncol 2019 Dec 26;14(1):236. Epub 2019 Dec 26.

Department of Radiation Oncology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.

Background: Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence. However, no studies have compared multi-treatment modalities, such as radiation therapy (RT), concurrent chemoradiotherapy (CCRT), surgery, chemotherapy, and best supportive care (BSC), across a sufficient number of patients with PALN recurrence. We thus aimed to evaluate the clinical outcomes of multi-treatment modalities for isolated PALN recurrence in uterine cervical cancer. Read More

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http://dx.doi.org/10.1186/s13014-019-1442-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933699PMC
December 2019

Bilateral ovarian granulocytic sarcoma as the primary manifestation of acute myelogenous leukemia treated with allogenic stem cell transplantation: A case report.

Medicine (Baltimore) 2019 Dec;98(52):e18390

Division of Hemato-oncology, Department of Internal Medicine.

Rationale: Granulocytic sarcoma (GS), also known as chloroma, is a tumor comprising myeloblasts or monoblasts, potentially occurring as an extramedullary mass. Systemic chemotherapy should be used to induce complete remission. However, such patients with chloroma have a poorer treatment outcome than those without extramedullary myeloid sarcomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000018390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946288PMC
December 2019

Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma.

Exp Oncol 2019 12;41(4):335-341

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv 03022, Ukraine.

The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers.

Materials And Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion (> ½ myometrium), n = 26, and with invasion < ½ myometrium, n = 11, with the use of morphological and immunohistochemical methods, and flow cytometry.

Results: In the morphological study of tumors with deep invasion in the myometrium, we have detected pronounced structural heterogeneity, which became the basis for the discretion of two groups of tumors with different characteristics of morphological phenotypes. Read More

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http://dx.doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-4.13965DOI Listing
December 2019

Autophagy up-regulation by ulipristal acetate as a novel target mechanism in the treatment of uterine leiomyoma: an in vitro study.

Fertil Steril 2019 12;112(6):1150-1159

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address:

Objective: To assess the effect of ulipristal acetate (UPA) on the autophagic process of uterine leiomyoma cells.

Design: In vitro study in primary cultures of leiomyoma and myometrial cells isolated from biopsy specimen, and gene expression evaluation in biopsy material.

Setting: Cellular pathology laboratory. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.08.007DOI Listing
December 2019

Targeting INHBA in Ovarian Cancer Cells Suppresses Cancer Xenograft Growth by Attenuating Stromal Fibroblast Activation.

Dis Markers 2019 11;2019:7275289. Epub 2019 Nov 11.

Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

INHBA-encoded inhibin A is a member of the transforming growth factor- (TGF-) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. Read More

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http://dx.doi.org/10.1155/2019/7275289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885285PMC

Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer.

BMC Cancer 2019 Dec 10;19(1):1202. Epub 2019 Dec 10.

Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been elucidated yet. Therefore, we evaluated the expression and clinical significance of FOXO1 and PAX3 in EOC. Read More

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http://dx.doi.org/10.1186/s12885-019-6406-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905044PMC
December 2019

An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer.

Gynecol Oncol 2020 01 7;156(1):222-232. Epub 2019 Dec 7.

Ovarian Cancer Research Center, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Objective: The aim of this study was to "humanize" ovarian cancer patient-derived xenograft (PDX) models by autologous transfer of patient-matched tumor infiltrating lymphocytes (TILs) to evaluate immunotherapies.

Methods: Orthotopic high-grade serous ovarian cancer (HGSOC) PDX models were established from three patient donors. Models were molecularly and histologically validated by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.10.011DOI Listing
January 2020
3.774 Impact Factor

New serum tumor markers S100, TFF3 and AIF-1 and their possible use in oncogynecology.

Ceska Gynekol 2019 ;84(4):303-308

Objective: To review a literature about possible new blood serum gynecologic tumor markers, S100 proteins family, trefoil factor 3 and AIF-1.

Design: Literature review.

Setting: Department of Obstetrics and Gynecology, Faculty of Medicine, Palacky University and University Hospital in Olomouc. Read More

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December 2019