Search Our Scientific Publications & Authors

Turk J Obstet Gynecol 2019 Mar 27;16(1):80-83. Epub 2019 Mar 27.

Suleyman Demirel University Faculty of Medicine, Department of Gynecologic Oncology, Isparta, Turkey.

Objective: Recurrent cervical cancer can cause severe morbidity. Despite the severe morbidity after surgery, pelvic exenteration is still used today for mainly curative intent. This intention is neither based on randomized controlled trials (RCTs) nor high quality non-RCTs with adequate patient numbers comparing medical management with surgery. Read More

Case Rep Obstet Gynecol 2019 25;2019:1870834. Epub 2019 Mar 25.

Department of Obstetrics & Gynecology, Western University, London, Canada.

Bilateral salpingo-oophorectomy (BSO) is increasingly employed as a risk-reducing strategy for epithelial ovarian cancer (EOC). We report the third case of a patient developing primary peritoneal cancer two decades after a bilateral salpingo-oophorectomy. This 66-year-old female underwent a hysterectomy for pelvic pain at age 28 and a subsequent bilateral salpingo-oophorectomy (BSO) at age of 45 for a pelvic mass. Read More

J Sex Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology. Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address:

Background: Vaginal diazepam is frequently used to treat pelvic floor tension myalgia and pelvic pain despite limited knowledge of systemic absorption.

Aim: To determine the pharmacokinetic and adverse event profile of diazepam vaginal suppositories.

Methods: We used a prospective pharmacokinetic design with repeated assessments of diazepam levels. Read More

Oncotarget 2019 Mar 12;10(21):2012-2021. Epub 2019 Mar 12.

Department of Gynecologic Oncology, Azienda Ospedaliera Brotzu, Cagliari, Italy.

Background: The treatment of patients with multiple synchronous tumors is challenging and complex. The use of next generation sequencing (NGS) may help in identification of germline mutations in genes involved in a common etiology for both tumors thus allowing a common effective therapeutic strategy.

Patients And Methods: We describe the unexpected positive results obtained in a young woman with relapsed chemo-resistant stage IVB cervical and synchronous stage IV lung cancer, who underwent an interdisciplinary approach including palliative surgery with laparoscopic total pelvic exenteratio followed by a chemo-immunotherapy protocol with the anti-Programmed Death (PD)-1 antibody nivolumab plus metronomic cyclophosphamide. Read More

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

J Minim Invasive Gynecol 2019 Apr 17. Epub 2019 Apr 17.

University of California San Francisco, Department of Obstetrics & Gynecology.

Study Objective: To evaluate opioid usage following benign gynecologic surgery after implementation of Enhanced Recovery After Surgery (ERAS) opioid prescribing recommendations.

Design: Prospective cohort study.

Setting: An academic tertiary care hospital PATIENTS: : All patients undergoing elective benign gynecologic surgery at a large academic institution between August 2017 - December 2017, one year after ERAS postoperative opioid prescribing recommendations were implemented for the benign gynecologic surgery department. Read More

J Minim Invasive Gynecol 2019 Apr 17. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL. Electronic address:

Study Objective: To compare the detection rate of adenomyosis when ultrasound is performed by a radiologist compared to a gynecologic expert sonologist.

Design: A retrospective, single center study.

Setting: University teaching hospital PATIENTS: All women above 18 years of age with a positive histopathology diagnosis of adenomyosis obtained in a hysterectomy specimen from October 1, 2011 - October 1, 2017 were screened for inclusion. Read More

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, 50134 Florence, Italy.

Physical activity (PA) interventions can improve physical functioning, treatment-related symptoms and quality of life (QoL) in cancer survivors. Most investigations have been conducted in breast cancer survivors, while studies on PA interventions in gynecological cancer survivors are scant. Here, we report for the first time the possible benefits of a structured PA pathway (i. Read More

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

Minerva Med 2019 Jun;110(3):209-215

Emergency and Intensive Care Department, ASST Papa Giovanni XXIII, Bergamo, Italy.

Background: Gynecological procedures are among the most frequent surgical interventions, and effective postoperative analgesia is associated with improved patient comfort. Despite the efficacy of neuraxial analgesia, limitations and potential complications have led to seek new strategies for pain relief. A novel, pre-programmed, non-invasive, hand-held system (Sufentanil Sublingual Tablet System [SSTS]) displayed good results in the orthopedic setting. Read More

J Minim Invasive Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Gynecologic Surgery, Mayo Clinic Arizona; 5777 East Mayo Boulevard; Phoenix, Arizona 85054. Electronic address:

Study Objective: Determine safety and feasibility of same-day discharge in patients undergoing vaginal hysterectomy with pelvic floor reconstruction.

Design: Prospective cohort pilot study.

Setting: Single academic medical center. Read More

Niger J Clin Pract 2019 Apr;22(4):478-484

Department of Anesthesiology and Reanimation, Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Demetevler, Ankara, Turkey.

Background: Analgesic protocol is needed following gynecologic surgery to ensure early mobilization, decrease the duration in the post-anesthetic care unit and hospitalization, and provide patient comfort. Transversus abdominis plane (TAP) blocks are used in the treatment of acute postoperative pain after lower abdominal surgery. TAP block may be a better choice of postoperative pain control. Read More

J Pediatr Adolesc Gynecol 2019 Apr 8. Epub 2019 Apr 8.

Department of Obstetrics, Gynecology, and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States.

Background: Complications associated with imperforate hymen include cyclical abdominal pain, acute urinary retention, endometriosis, and even iatrogenic infections.

Case: A 14 year old female was diagnosed with an imperforate hymen, hematocolpos, and right hematosalpinx. A hymenotomy was performed, followed by a hymenectomy three days later. Read More

J Oncol Pract 2019 Apr 9:JOP1800639. Epub 2019 Apr 9.

1 University of Pennsylvania Health System, Philadelphia, PA.

Purpose: Seventeen percent of patients with cancer visit the emergency department (ED) annually, often with nonemergent complaints. We sought to describe the burden of treat-and-release ED utilization by patients with gynecologic cancers and to identify opportunities for improved triage.

Materials And Methods: Patients with gynecologic cancer diagnoses who were treated and released were identified within the Nationwide Emergency Department Sample, a stratified sample of US hospital-based ED visits, from 2009 to 2013. Read More

Gynecol Endocrinol 2019 Apr 7:1-5. Epub 2019 Apr 7.

a Student Research Committee, School of Health , Qazvin University of Medical Sciences , Qazvin , Iran.

Primary dysmenorrhea is a common gynecologic disorder and is one of the main causes for referral to the gynecology clinic. This study aimed to determine the effects of alpha-lipoic acid (ALA) and mefenamic acid and a combination compared with placebo on the girls with primary dysmenorrhea. This double-blind, placebo-controlled clinical trial done on population consisted of female students living in dormitories of Qazvin University of Medical Sciences who had moderate to severe dysmenorrhea using the Visual Analog Scale (VAS) questionnaire. Read More

Pain Res Treat 2019 4;2019:2405159. Epub 2019 Mar 4.

Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Objective: To examine the effectiveness of cryotherapy for reducing postoperative pain in patients who underwent exploratory laparotomy for gynecologic surgery.

Materials And Methods: Patients who had indication for an exploratory laparotomy gynecologic procedure were selected by attending physicians to undergo abdominal surgery via low transverse skin incision. The participants were randomized into study and control groups with simple random sampling methods. Read More

Am J Dermatopathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA.

Cutaneous endometriosis is an uncommon dermatologic disorder predominantly seen in young women. Most commonly, it presents within a region of a previous surgical scar, often in relation to a gynecologic procedure on the abdomen or in close proximity to the umbilicus. The typical clinical presentation is that of papules or nodules with monthly cyclical pain and size variation. Read More

Emerg Med Clin North Am 2019 May;37(2):207-218

Medstar Georgetown University Hospital, 3800 Reservoir Road Northwest, Washington, DC 20007, USA.

Acute pelvic pain has gynecologic and nongynecologic causes, and distinguishing between them can be difficult in the emergency department. Ovarian cysts, adnexal torsion, and pelvic inflammatory disease are conditions that emergency physicians must be able to identify. Pelvic pathologic condition can be readily assessed with ultrasound but has significant limitations. Read More

Minerva Anestesiol 2019 Mar 29. Epub 2019 Mar 29.

Department of Critical Care Area Monaldi Hospital, Ospedali dei Colli, Naples, Italy.

Introduction: Proper management of patients undergoing robotic-assisted urologic and gynecologic surgery must consider a series of peculiarities in the procedures for anesthesiology, critical care medicine, respiratory care, and pain management. Although the indications for robotic-assisted urogynecologic surgeries have increased in recent years, specific guidance documents are still lacking.

Evidence Acquisition: Multidisciplinary group including anesthesiologists, gynecologists, urologists, and a clinical epidemiologist systematically reviewed the relevant literature and provided a set of recommendations and unmet needs on peculiar aspects of anesthesia in this field. Read More

J Minim Invasive Gynecol 2019 Mar 28. Epub 2019 Mar 28.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea (Dr. Kim). Electronic address:

Study Objective: Post-laparoscopic shoulder pain (PLSP) is effectively reduced by a pulmonary recruitment maneuver (PRM). The goal of this study is to assess the efficacy of a PRM using maximal inspiratory pressure of 30 cm HO, which is lower than previously studied pressure for reducing PLSP.

Design: Randomized controlled trial. Read More

Sex Med Rev 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada; BC Women's Centre for Pelvic Pain and Endometriosis, Vancouver, BC, Canada; Women's Health Research Institute, Vancouver, BC, Canada. Electronic address:

Introduction: Dyspareunia has been traditionally divided into superficial (introital) dyspareunia and deep dyspareunia (pain with deep penetration). While deep dyspareunia can coexist with a variety of conditions, recent work in endometriosis has demonstrated that coexistence does not necessarily imply causation. Therefore, a reconsideration of the literature is required to clarify the pathophysiology of deep dyspareunia. Read More

Radiol Clin North Am 2019 May 14;57(3):601-616. Epub 2019 Feb 14.

Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.

Pelvic ultrasound with endovaginal ultrasound is often the imaging test of choice in the initial evaluation of nonpregnant women with pelvic pain. This article considers the sonographic observations and techniques useful in diagnosis of a variety of gynecologic causes of pelvic pain in these women, including ovarian hemorrhage, ovarian torsion, pelvic inflammatory disease, endometriosis (particularly deeply infiltrating endometriosis), endometriomas, adenomyosis, pelvic congestion syndrome, and malpositioned intrauterine contraceptive devices. Sonographic observations regarding a number of non-gynecologic causes of pelvic pain are also described. Read More

Int Urogynecol J 2019 Mar 27. Epub 2019 Mar 27.

Department of Urogynaecology, Birmingham Women's NHS Foundation Trust, Edgbaston, UK.

Introduction And Hypothesis: Management of pain or mesh exposure complications after stress incontinence surgery has become a new issue over the last 20 years with the introduction of mesh techniques to treat stress incontinence. There is much debate regarding the incidence of complications and how best to treat them.

Methods: A working subcommittee from the International Urogynecology Association (IUGA) Research and Development (R&D) Committee was formed. Read More

Asian Pac J Cancer Prev 2019 Mar 26;20(3):869-875. Epub 2019 Mar 26.

Indonesia Ministry of Health, Immunization Sub-Directorate at Directorate of Surveillance, Immunization and Health Quarantine, Jakarta, Indonesia.

Objective: Quadrivalent human papillomavirus (QHPV) vaccine has been advised for routine vaccination of pre-adolescent girls globally, and a two-dose QHPV vaccination schedule has been introduced in Indonesia to vaccinate 5th and 6th grade elementary school female students. This post-marketing surveillance study evaluated the possible adverse events following immunization with the two-dose QHPV vaccine in Indonesia. Methods: Girls studying in grade 6 of five designated elementary schools in Jakarta, receiving their 2nd dose of QHPV vaccine and provided informed consent (represented by their parents), were included in the study. Read More

Integr Cancer Ther 2019 Jan-Dec;18:1534735419836501

2 Prince of Wales Hospital, Sha Tin, Hong Kong SAR.

Purpose: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy.

Methods: Randomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Read More

Int J Cancer 2019 Mar 22. Epub 2019 Mar 22.

Department of Gynecology, Erlangen University Hospital, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.

One of the most common adverse events (AEs) occurring during treatment with aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to analyze the influence of preexisting muscle/limb pain and joint pain on the development of AI-induced musculoskeletal AEs. Women eligible for upfront adjuvant endocrine therapy with letrozole were included in the PreFace study, a multicenter phase IV trial. Read More

Sex Med 2019 Mar 15. Epub 2019 Mar 15.

Hospital Universitario Dexeus, Barcelona, Spain.

Introduction: The prevalence of menopausal women with confirmed vulvovaginal atrophy (VVA) oscillates between 67-98%.

Aim: To assess the prevalence of postmenopausal women with VVA confirmed by gynecologic clinical assessment among all women attending menopause centers in Spain, as well as to describe the impact of VVA on quality of life and sexual functioning.

Methods: Women aged 45-75 years old with the last menstrual period >12 months before were included in a cross-sectional study. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14579

Department of Gynecology, Second Hospital of Hebei Medical University, Shijiazhuang, China.

To evaluate the clinical efficacy and safety of adenomyomectomy using "H" type incision combined with Mirena (LNG-IUS) in the treatment of adenomyosis.A total of 57 women with adenomyosis who underwent adenomyomectomy using "H" type incision combined with LNG-IUS were selected. Visual analog scale (VAS), menstrual flow, uterine volume, serum CA125 levels and hemoglobin amounts were compared before and after the surgery. Read More

J Pain Symptom Manage 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, USA. Electronic address:

Context/objectives: We sought to characterize patterns of social support types (i.e., emotional, informational, appraisal, and instrumental) within the caregiver/spouse, family, and spiritual/religious contexts for patients diagnosed with cancer. Read More

Gynecol Oncol 2019 03;152(3):509-513

Montefiore Medical Center, Department of Obstetrics & Gynecology and Women's Health, Bronx, NY, United States of America; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, United States of America.

Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS®) Network has developed a comprehensive repository of electronic patient reported outcomes measures (ePROs) of major symptom domains that have been validated in cancer patients. Their use for patients with gynecologic cancer has been understudied. Our objective was to establish feasibility and acceptability of PROMIS ePRO integration in a gynecologic oncology outpatient clinic and assess if it can help identify severely symptomatic patients and increase referral to supportive services. Read More

Gynecol Oncol 2019 03;152(3):492-500

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.

Objective: Using patient-reported outcomes (PROs) in perioperative care is increasingly common. We report the development, validation, and application of an MD Anderson Symptom Inventory version for use in patients undergoing surgery for gynecologic cancer or benign conditions (MDASI-PeriOp-GYN).

Methods: Our process included: (1) generating PeriOp-GYN-specific candidate items from qualitative interviews with patients, followed by input from an expert panel; (2) dropping items that lacked independent clinical relevance; (3) validating psychometric properties (reliability, validity) of the resulting MDASI-PeriOp-GYN; and (4) conducting cognitive debriefing interviews with patients to confirm ease of comprehension, relevance, and acceptability. Read More

Abdom Radiol (NY) 2019 Mar 13. Epub 2019 Mar 13.

Department of Radiology, Louisiana State University Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.

Purpose: To evaluate outcomes of image-guided transrectal/transvaginal (TR/TV) drainage for symptomatic pelvic fluid collections (SPFCs).

Materials And Methods: Single-center retrospective study of 150 consecutive patients (36 males, 114 females, average age 41 years) who underwent attempted TR/TV drainages of SPFCs during an 11-year, 5-month period. All patients presented with pain and had SPFCs with rectal or vaginal contact on preceding diagnostic CT. Read More

Clinicoecon Outcomes Res 2019 22;11:169-177. Epub 2019 Feb 22.

Health Economics & Outcomes Research, Pfizer Inc, New York, NY, USA.

Purpose: The use of parecoxib plus opioids for postoperative analgesia in noncardiac surgical patients seems to be cost-saving in Europe due to a reduction in opioid use and opioid-related adverse events. Given the lack of information on postoperative analgesic use in Asia, this study assessed the economic consequences of the addition of parecoxib to opioids vs opioids alone to treat postsurgical pain in China.

Methods: A cost-consequence economic evaluation assessed direct medical costs related to opioid-related clinically meaningful events (CMEs) utilizing dosing information and reported frequency of events from a Phase III, randomized, double-blind, global clinical trial (PARA-0505-069) of parecoxib plus opioids vs opioids alone for 3 days following major orthopedic, abdominal, gynecologic, or noncardiac thoracic surgery requiring general or regional anesthesia. Read More

BMJ Open 2019 Mar 4;9(3):e024484. Epub 2019 Mar 4.

Department of Anesthesiology and Intensive Care, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Objectives: We aimed to determine whether regional analgesia with intrathecal morphine (ITM) in an enhanced recovery programme (enhanced recovery after surgery [ERAS]) gives a shorter hospital stay with good pain relief and equal health-related quality of life (QoL) to epidural analgesia (EDA) in women after midline laparotomy for proven or assumed gynaecological malignancies.

Design: An open-label, randomised, single-centre study.

Setting: A tertiary referral Swedish university hospital. Read More

Am J Obstet Gynecol 2019 Mar 25;220(3):259.e1-259.e11. Epub 2018 Oct 25.

Center for Minimally Invasive Gynecologic Surgery, Newton-Wellesley Hospital, Newton, MA.

Background: In the setting of America's opioid epidemic, judicious postoperative opioid prescribing is important. Gynecologists lack standard guidelines about postoperative opioid prescriptions.

Objectives: The objectives of the study were to describe opioid prescribing practices by a group of minimally invasive gynecologic surgeons, to measure postoperative opioid use after minimally invasive hysterectomy, and to identify preoperative factors that could predict whether a patient will be a low or high postoperative opioid user. Read More

Reprod Sci 2019 Mar 4:1933719119833483. Epub 2019 Mar 4.

1 Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, People's Republic of China.

The myometrium, especially the junctional zone (JZ), is now well documented to have a role in the pathogenesis of adenomyosis. Cannabinoid receptors have been shown to participate in the establishment of endometriosis and its pain perception. However, its relation to adenomyosis has not been identified yet. Read More

J Matern Fetal Neonatal Med 2019 Mar 8:1-6. Epub 2019 Mar 8.

e Nursing Department , Islamic Azad University , Hamadan , Iran.

Background: Given the increasing rate of cesarean delivery and request without maternal or fetal indication among pregnant women, this systematic review was conducted to obtain the reasons for maternal request for elective cesarean section.

Methods: We searched published studies from the first year of records through August 2018 in PubMed, Scopus, and Web of Science. The quality assessment of the studies was performed by the improved Newcastle-Ottawa Scale. Read More

Gynecol Oncol 2019 Feb 23. Epub 2019 Feb 23.

Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark; Faculty of Health Sciences, Clinical Institute, University of Southern Denmark, Odense, Denmark.

Objective: To assess early recovery of physical health after robotic minimally invasive surgery (RMIS) for early-stage endometrial cancer using the European Organisation of Research and Treatment of Cancer Computer Adaptive Test Core questionnaire (EORTC CAT Core). The EORTC CAT Core provides individualised measurements while maintaining comparability. A hypothesis of individual complete recovery to baseline within three post-surgical weeks was evaluated. Read More

Med Acupunct 2019 Feb 7;31(1):29-36. Epub 2019 Feb 7.

Academy of Acupuncture Surabaya, Jawa Timur, Indonesia.

A natural-killer (NK) cell is a cytotoxic lymphocyte that responds to tumor formation. Electroacupuncture (EA) in patients with cancer, who had chemotherapy, enabled them to maintain their T-cell counts (CD3+, CD4+, and CD8+) and NK-cell activity. To evaluate NK-cell levels and tumor sizes in patients with cervical squamous-cell carcinoma (SCC) after EA on ST 36 (). Read More

Gynecol Oncol 2019 Feb 21. Epub 2019 Feb 21.

Division of Gynecologic Oncology, Washington University, St. Louis, MO, United States of America. Electronic address:

Objective: To compare the incidence of postoperative complications and opioid pain medication usage in gynecologic oncology patients who did and did not receive an epidural prior to undergoing exploratory laparotomy.

Methods: Retrospective cohort study of all patients undergoing exploratory laparotomy with the gynecologic oncology division at Washington University in St Louis between January 2012 and October 2015. Data on demographics, pathology, postoperative pain and opioid use, and incidence of postoperative complications were collected. Read More

Blood Cancer J 2019 Feb 22;9(3):23. Epub 2019 Feb 22.

Universitatsklinikum Tubingen, Tubingen, Germany.

We examined effects of carfilzomib-dexamethasone (Kd56) versus bortezomib-dexamethasone (Vd) on health-related quality of life (HR-QoL) in relapsed/refractory multiple myeloma (MM) patients from the ENDEAVOR study. HR-QoL was assessed by the European Organisation for Research and Treatment of Cancer QoL Questionnaire (QLQ-C30), MM-specific module (QLQ-MY20), and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT-GOG-Ntx) "Additional Concerns" neurotoxicity subscale. The QLQ-C30 Global Health Status (GHS)/QoL scale and seven prespecified subscales were compared between groups using mixed model for repeated measures. Read More

J Minim Invasive Gynecol 2019 Feb 18. Epub 2019 Feb 18.

Jerusalem, Israel.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000010. Epub 2019 Feb 14.

Associate Professor III, Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP, Botucatu-SP, Brazil. Conception and design of the study, manuscript preparation.

Purpose: To evaluate agreement between pre- and post-laparoscopy gynecological diagnosis in order to demonstrate the rationality of this minimally invasive technique use in gynecological propaedeutics.

Methods: Retrospective chart review study conducted between March 2010 and October 2016 based on a convenience sample. 315 patients undergoing surgical laparoscopy at the Center of Gynecologic Endoscopy and Family Planning of Botucatu Medical School/UNESP. Read More

Anesth Analg 2019 05;128(5):944-952

From the Department of Anesthesiology.

Background: Postoperative delirium is an important public health concern without effective prevention strategies. This study tested the hypothesis that perioperative epidural use would be associated with decreased risk of delirium through postoperative day 3.

Methods: This was a secondary, observational, nonrandomized analysis of data from The Prevention of Delirium and Complications Associated With Surgical Treatments Trial (PODCAST; NCT01690988). Read More

Lancet Oncol 2019 Mar 8;20(3):383-393. Epub 2019 Feb 8.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

Cureus 2018 Nov 30;10(11):e3657. Epub 2018 Nov 30.

Emergency Medicine, University of Central Florida College of Medicine, Orlando, USA.

Mucinous cystadenomas are a common benign neoplasm of the ovaries that can grow much larger than other adnexal masses. We report a case of a 28-year-old female who presented with one month of increasing abdominal distension and upper abdominal pain; she was found to have a 30-centimeter (cm) adnexal mass. Pathology showed a benign mucinous cystadenoma with no evidence of malignancy. Read More

Am J Obstet Gynecol 2019 Feb 6. Epub 2019 Feb 6.

Ottawa Hospital Research Institute, Ottawa, Canada; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Canada.

Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive-aged women. It commonly presents with pelvic pain, painful periods, and infertility and can significantly have an impact on one's quality of life. Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women. Read More

Reg Anesth Pain Med 2019 Feb 7. Epub 2019 Feb 7.

Anesthesiology, Hospital for Special Surgery, New York City, New York, USA.

Enhanced recovery after surgery (ERAS) protocols for gynecologic (GYN) surgery are increasingly being reported and may be associated with superior outcomes, reduced length of hospital stay, and cost savings. The Agency for Healthcare Research and Quality, in partnership with the American College of Surgeons and the Johns Hopkins Medicine Armstrong Institute for Patient Safety and Quality, has developed the Safety Program for Improving Surgical Care and Recovery, which is a nationwide initiative to disseminate best practices in perioperative care to more than 750 hospitals across five major surgical service lines in a 5-year period. The program is designed to identify evidence-based process measures shown to prevent healthcare-associated conditions and hasten recovery after surgery, integrate those into a comprehensive service line-based pathway, and assist hospitals in program implementation. Read More

Am J Case Rep 2019 Feb 8;20:167-170. Epub 2019 Feb 8.

Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia.

BACKGROUND Uterine leiomyoma, or uterine fibroid, is the most common gynecologic neoplasm and its management usually results in a good clinical outcome. This report is of a rare case of hemoperitoneum associated with spontaneous hemorrhage from a benign uterine leiomyoma. CASE REPORT A 27-year-old single woman presented with generalized acute abdominal pain and vomiting. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 30;234:218-222. Epub 2019 Jan 30.

Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Gynecology, San Carlo di Nancy Hospital, Rome, Italy.

Objective: To investigate the safety, feasibility and oncological adequacy of the Percutaneous Surgical System - PSS in a consecutive series of low-risk endometrial cancer staging.

Study Design: From May 2015 to April 2017, we prospectively performed 30 consecutive percutaneous staging for low/intermediate risk endometrial cancer (FIGO stage IA G1-G2, IB G1-G2, IA G3). All patients were divided in two different groups on the basis of surgical procedure received: Group A included patients submitted to radical Class A hysterectomy and bilateral salpingo-oophorectomy; Group B concerned patients that received a lymph nodal assessment also. Read More