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Female Pelvic Med Reconstr Surg 2022 Jun 18. Epub 2022 Jun 18.

From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology.

Importance: Women with interstitial cystitis/bladder pain syndrome (ICBPS) face challenging treatment and feelings of isolation. Centering models of group medical visits have been successful in other spheres but have not been explored in ICBPS therapy.

Objective: We sought to describe opinions of women with ICBPS regarding Centering visits, including advantages, experience, and barriers to participation and efficacy. Read More

Updates Surg 2022 Jun 27. Epub 2022 Jun 27.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

The purpose of this study is to assess the feasibility and the perioperative outcomes of laparoscopic gynecological surgery in regional anesthesia (RA) from the point of view of the surgeon, anesthesiologist and patient. This is a prospective cohort study comprising sixty-six women planned to undergo gynecologic laparoscopy surgery for benign pathology at tertiary care gynecolgical center of the University Federico II of Naples. Women were assigned, according to their preference, to either RA (Group A) or general anesthesia (GA) (Group B). Read More

Front Med (Lausanne) 2022 9;9:872481. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: This study aimed to establish an effective prognostic nomogram for the postoperative recurrence of endometrioma or endometriosis-related pain for patients with endometrioma after long-term follow-up, who were younger than 45 years old and received postoperative therapy.

Methods: The predictive nomogram was based on 323 patients who underwent cystectomy for endometrioma at Perking Union Medical College Hospital from January 2009 to April 2013, and the last follow-up occurred in September 2018. We collected information on all included patients, including preoperative data, intraoperative data, and long-term follow-up data after surgery. Read More

Obstet Gynecol Sci 2022 Jun 27. Epub 2022 Jun 27.

Department of Obstetrics and Gynecology, Dongguk University College of Medicine, Goyang, Korea.

Objective: This study aims to evaluate the safety and feasibility of laterally extended endopelvic resection (LEER) for sarcoma in the female genital tract.

Methods: We prospectively recruited gynecologic cancer patients with sarcoma arising from female genital tract who underwent LEER at Seoul National University Hospital from December 2016 to March 2021. Clinicopathologic characteristics, surgical outcomes including postoperative complications and pain control, and survival outcomes of the patients were investigated. Read More

Int J Gynaecol Obstet 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Cholet Hospital, 49300, Cholet, France.

Objective: To analyze outcomes and postoperative complications in patients undergoing robot-assisted isthmocele repair.

Method: This retrospective cohort study included 33 patients who had robot-assisted laparoscopic surgical management of an isthmocele between September 2013 and August 2020 in two French university hospitals. All charts were reviewed to identify patient characteristics, pre- and postoperative anatomical findings, complications, and postoperative fertility and symptoms. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221106755

Texas Tech University Health Sciences Center El Paso, TX, USA.

Colorectal carcinoma (CRC) is a common malignancy with steadily declining incidence rates and mortality, secondary to improved screening and lifestyle changes (eg, decreased smoking rates). The association between pelvic inflammatory disease (PID) and CRC has been unclear in the past. However, multiple studies showed a positive association between PID and underlying malignancy (gynecologic and pelvic primarily). Read More

J Pers Med 2022 May 26;12(6). Epub 2022 May 26.

Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Single-port access (SPA) laparoscopic surgery and vaginal natural orifice transluminal endoscopic surgery (vNOTES) have many advantages. The objective of the present study is to compare patient characteristics, operative details, and postoperative outcomes between the two surgical methods. Patients who were planned to undergo vNOTES or SPA laparoscopic surgery between April 2020 and June 2021 were prospectively enrolled. Read More

Gynecol Oncol 2022 Jun 20. Epub 2022 Jun 20.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Gynecology, Augustenburger Platz 1, 13353 Berlin, Germany; Tumor Bank Ovarian Cancer, ENGOT Biobank, Charité Medizinische Universität Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Background: High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer and is associated with high mortality rates. Surgical outcome is one of the most important prognostic factors. There are no valid biomarkers to identify which patients may benefit from a primary debulking approach. Read More

Langenbecks Arch Surg 2022 Jun 22. Epub 2022 Jun 22.

Female Pelvic Medicine and Reconstructive Surgery, Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, 2020 Zonal Ave., Room 220, Los Angeles, CA, 90033, USA.

Objective: To investigate the effect of postoperative prune consumption on time to first bowel movement after benign gynecologic surgery.

Materials And Methods: In this randomized, open label, controlled trial, 77 adult women who had benign gynecologic surgery that required at least one night in the hospital were enrolled from July 2018 to April 2019. Participants were randomized in a 1:1 ratio to one of two groups using a randomization assignment: 4 oz prunes daily plus docusate sodium 100 g twice daily versus docusate alone. Read More

J Comp Eff Res 2022 Aug 21;11(11):843-851. Epub 2022 Jun 21.

University of Central Florida College of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology, Orlando, FL, 32827 USA.

Despite significant controversy, vaginal laser therapy continues to be used for treatment of many gynecologic and pelvic conditions including vaginal atrophy, vaginal dryness, dyspareunia, urinary incontinence and pelvic pain. This commentary reviews the controversy surrounding vaginal laser therapy and summarizes the important distinction between ablative and non-ablative vaginal lasers. While much research is still needed, the article describes what is important for healthcare professionals to know before making the decision to integrate this technology into their clinical practice. Read More

J Minim Invasive Gynecol 2022 Jun 16. Epub 2022 Jun 16.

Department of Gynecologic Surgery, Mayo Clinic Arizona; 5777 East Mayo Boulevard; Phoenix, Arizona 85054.

J Gynecol Oncol 2022 Jun 3. Epub 2022 Jun 3.

Department of Urology and Gynecology, Istituto Nazionale Tumori, IRCSS, "Fondazione G. Pascale", Naples, Italy.

Objective: The European Society of Gynaecological Oncology (ESGO)-quality indicators (QIs) for advanced ovarian cancer (AOC) have been assessed only by few Italian centers, and data are not available on the proportion of centers reaching the score considered for a satisfactory surgical management. There is great consensus that the Enhanced Recovery After Surgery (ERAS) approach is beneficial, but there is paucity of data concerning its application in AOC. This survey was aimed at gathering detailed information on perioperative management of AOC patients within MITO-MaNGO Groups. Read More

Gynecol Oncol Rep 2022 Aug 25;42:101008. Epub 2022 May 25.

Division of Gynecologic Oncology, Obstetrics and Gynecology Department, University of Virginia, Charlottesville, VA, United States.

Background: Post-operative opiate prescribing has traditionally been stratified by procedure type with little regard for patient opiate utilization. We sought to evaluate peri-operative factors associated with patient opiate utilization post-operatively to develop, implement, and assess a discharge prescribing intervention.

Study Design: This was a quality improvement study of opiate prescribing practices for patients undergoing gynecologic surgery on an enhanced recovery pathway (ERAS) pre- and post-discharge prescription intervention. Read More

Interv Cardiol Clin 2022 Jul;11(3):307-324

The Ohio State University, 281 West Lane Avenue, Columbus, OH 43210, USA. Electronic address:

Pelvic venous disorders are inter-related pathologic conditions caused by reflux and obstruction in the pelvic veins. It can present a spectrum of clinical features based on the route of transmission of venous hypertension to either distal or caudal venous reservoirs. Imaging can help to visualize pelvic vascular and visceral structures to rule out other gynecologic, gastrointestinal, and urologic diseases. Read More

Clin Obstet Gynecol 2022 Jun 17. Epub 2022 Jun 17.

Methodist Dallas Cancer Center, Dallas, Texas.

Breast disorders arise from a myriad of etiologies. They are frequent reasons for patient encounters in primary care and obstetric and gynecologic practices. The most common complaints include breast pain, nipple discharge and breast lumps or masses. Read More

Clin Obstet Gynecol 2022 Jun 16. Epub 2022 Jun 16.

Department of Obstetrics & Gynecology, University of Michigan, Ann Arbor, Michigan.

Benign breast disease presents commonly in routine gynecologic care. Presenting symptoms such as breast mass, nipple discharge, or breast pain may raise concern for malignancy. Once breast cancer is ruled out, gynecologists must identify and appropriately treat benign breast disease. Read More

Reprod Fertil 2022 Apr 20;3(2):R91-R95. Epub 2022 Apr 20.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Endometriosis has a large impact on the lives of patients, affecting nearly 90% of women with chronic pelvic pain and infertility. Unfortunately, diagnosis for this condition is often delayed by an average of 7 years, with adolescent patients experiencing disproportionate delays. This is in part due to the use of an invasive procedure for primary diagnosis and limited access to subspecialty care. Read More

J Pain Symptom Manage 2022 Jun 11. Epub 2022 Jun 11.

Cornell Center for Research on End-of-Life Care, Weill Cornell, New York, NY; Department of Medicine, Weill Cornell Medicine, New York, NY; Department of Radiology, Weill Cornell Medicine, New York, NY.

Fertil Steril 2022 Jun 9. Epub 2022 Jun 9.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas. Electronic address:

Objective: To describe a novel, minimally invasive technique for performing myomectomy, a fertility-sparing procedure.

Design: This technique was developed based on similar techniques for other surgeries that showed a benefit. Liu et al. Read More

J Minim Invasive Gynecol 2022 Jun 9. Epub 2022 Jun 9.

Brigham & Women's Hospital, Division of Minimally Invasive Gynecologic Surgery, Harvard Medical School, Boston, MA.

Study Objective: The objective of this case series is to evaluate the rates of ureteral injury at the time of laparoscopic hysterectomy among high-volume fellowship-trained surgeons.

Design: A retrospective chart review was performed, evaluating laparoscopic hysterectomy cases between 2009-2019 performed exclusively by fellowship-trained surgeons.

Setting: Division of Minimally Invasive Gynecologic Surgery (MIGS) at the Brigham & Women's Hospital and Brigham & Women's Faulkner Hospital, a Harvard Medical School teaching hospital in Boston. Read More

J Pediatr Adolesc Gynecol 2022 Jun 9. Epub 2022 Jun 9.

Tergooi MC, Department of Obstetrics and Gynecology, van Riebeeckweg 212, 1213 XZ, Hilversum, The Netherlands. Electronic address:

Objective: The purpose of this study is to evaluate the resident trainees' perspective of the pediatric and adolescent gynecology training in obstetrics and gynecology training programs in Europe.

Study Design: This study was a cross-sectional survey using an online questionnaire, based on the PAG training in obstetrics and gynecology section of European Board & College of Obstetrics and Gynecology Project of Achieving Consensus in Training curriculum. We aimed to survey the national programs in 35 ENTOG member countries. Read More

Int J Mol Sci 2022 May 30;23(11). Epub 2022 May 30.

Jiangsu Provincial Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Primary dysmenorrhea is one of the most common reasons for gynecologic visits, but due to the lack of suitable animal models, the pathologic mechanisms and related drug development are limited. Herein, we establish a new mouse model which can mimic the periodic occurrence of primary dysmenorrhea to solve this problem. Non-pregnant female mice were pretreated with estradiol benzoate for 3 consecutive days. Read More

Int J Gynecol Cancer 2022 Jun 9. Epub 2022 Jun 9.

Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Objective: Pelvic floor dysfunction is a common adverse effect of uterine cancer treatment. In this study we compared patient-reported outcomes regarding pelvic floor dysfunction among uterine cancer survivors after hysterectomy and bilateral salpingo-oophorectomy, surgery and brachytherapy, or surgery and external beam radiotherapy with or without brachytherapy versus women who had a hysterectomy for benign indications.

Methods: We used the validated 20-item Pelvic Floor Distress Inventory to assess lower urinary distress, colorectal distress, and pelvic organ prolapse dysfunction in each treatment group. Read More

Int J Gynecol Cancer 2022 Jun 9. Epub 2022 Jun 9.

Gynecologic, Sorlandet Hospital Kristiansand, Kristiansand, Norway.

Objective: The survival benefit of monitoring CA125 in ovarian cancer patients after primary treatment is debated due to findings varying from insignificant survival differences to prolonged median overall survival in favor of asymptomatic patients. Hence we aimed to compare ovarian cancer patients with and without symptoms at the time of the first diagnosed recurrence in terms of post-recurrence survival and overall survival, and to explore time to recurrence and common symptoms at recurrence.

Methods: We included 421 women with ovarian cancer from a prospective multi-institutional Norwegian study of first recurrence of gynecological cancer over the period from March 2012 to April 2016. Read More

Int J Gynecol Cancer 2022 Jun 9. Epub 2022 Jun 9.

Gynecologic Oncology, West Cancer Center, Memphis, Tennessee, USA

Objective: Radiofrequency ablation and microwave ablation are used to vaporize tumors not amenable to surgical resection. We sought to evaluate the safety and efficacy of radiofrequency and microwave ablation for the treatment of isolated lesions in patients with recurrent gynecologic malignancy.

Methods: Patients with gynecologic malignancies treated with radiofrequency or microwave ablation at a university-affiliated cancer center from April 2007 to January 2020 were evaluated. Read More

Obstet Gynecol 2022 Jun;139(6):1201

Abstract: Lower gastrointestinal (GI) diseases and associated symptoms account for a large number of health care visits each year. Many women visit their obstetrician-gynecologists more often than their primary care physicians or use them as primary health care providers. Many gynecologic and lower GI disorders share symptoms, such as lower abdominal or pelvic pain and bloating. Read More

Pak J Pharm Sci 2022 Mar;35(2(Special)):641-647

Department of Anesthesiology, Tangshan People's Hospital, Tangshan, Hebei, China.

To evaluate the efficacy of multimodal analgesia of flurbiprofen axetil, nalbuphine hydrochloride and patient controlled intravenous analgesia (PCIA) on inflammatory factor levels and stress response in patients after laparoscopic radical gynecological malignancy surgery. The data of 100 patients admitted to our hospital from May 2019 to May 2020 for laparoscopic radical gynecological malignancy surgery were retrospectively analyzed and they were assigned (1:1) to either an experimental group or a control group according to the alphabetical order of their initials. The experimental group was given preemptive analgesia with flurbiprofen axetil, postoperative analgesia with nalbuphine hydrochloride, and PCIA and the control group was given conventional analgesic measures. Read More

J Chin Med Assoc 2022 Jun 6. Epub 2022 Jun 6.

Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan, ROC.

Background: Robotic total hysterectomies have been considered contraindicated for patients with intra-abdominal adherences, but the evidence for this is not strong, and we hypothesized that the procedure can be of benefit even in these cases. In our research, we analyzed how the severity of pelvic adhesions affect robotic total hysterectomy, and by comparing different types of adhesions, we can further identify the outcomes differences in between, which may aid in future surgical decision making.

Methods: Retrospective cohort study (Design Classification II-2) Patients and Interventions: All 410 patients with uterine myoma or adenomyosis undergoing robotic total hysterectomies between 2011 and 2016 using the da Vinci Si system by the same surgeon in TMUH were included in the study. Read More

J Opioid Manag 2022 May-Jun;18(3):229-236

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, Connecticut. ORCID: https://orcid.org/0000-0001-8337-4216.

Objective: To analyze the effect of the Connecticut Prescription Monitoring and Reporting System (CPMRS) on the number of opioid tablets prescribed to gynecologic oncology patients post-operatively.

Design/participants: This was a retrospective chart review of patients who received surgery for suspicious masses, premalignant, or malignant conditions of uterus, tubes, ovaries, or cervix. Charts were divided into two groups before and after the implementation of an updated prescription monitoring system in July 2016. Read More

J Clin Transl Sci 2022 1;6(1):e45. Epub 2022 Apr 1.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.

Background: Minority and older adult patients remain underrepresented in cancer clinical trials (CCTs). The current study sought to examine sociodemographic inequities in CCT interest, eligibility, enrollment, decline motivation, and attrition across two psychosocial CCTs for gynecologic, gastrointestinal, and thoracic cancers.

Methods: Patients were approached for recruitment to one of two interventions: (1) a randomized control trial (RCT) examining effects of a cognitive-behavioral intervention targeting sleep, pain, mood, cytokines, and cortisol following surgery, or (2) a yoga intervention to determine its feasibility, acceptability, and effects on mitigating distress. Read More