386 results match your criteria Gynecologic Needle Biopsy


Ultrasound-Guided Trans-Uterine Cavity Core Needle Biopsy of Uterine Myometrial Tumors to Differentiate Sarcoma from a Benign Lesion-Description of the Method and Review of the Literature.

Diagnostics (Basel) 2022 May 29;12(6). Epub 2022 May 29.

Department of Surgical Oncology, Institut Curie, University of Paris, 26 Rue d'Ulm, CEDEX 05, 75248 Paris, France.

Uterine sarcomas are rare, aggressive tumors with poor prognosis that can be further negatively affected by inadequate surgical approaches such as morcellation. There are no clinical and radiologic criteria for differentiating leiomyoma from malignant uterine tumors. However, some ultrasonography and magnetic resonance imaging findings may be informative. Read More

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Metastatic High-Grade Endometrial Stromal Sarcoma with Translocation to the Pleural Fluid: A Case Report.

Int J Surg Pathol 2022 May 16:10668969221098093. Epub 2022 May 16.

Department of Pathology, Immunology, & Lab Medicine, College of Medicine, 12233University of Florida, Gainesville, Florida, USA.

Sarcomas in cytology fluids are uncommon, accounting for an estimated 3-6% of malignant effusions. High-grade endometrial stromal sarcomas are uncommon malignancies, whose true frequency is not well defined. We present a case of high-grade endometrial stromal sarcoma with a translocation metastatic to the pleural fluid. Read More

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Ultrasound-guided Needle Biopsy for Preoperative Assessment of Uterine Fibroids: Our Experience and a Review of the Literature.

Gynecol Minim Invasive Ther 2022 Jan-Mar;11(1):47-50. Epub 2022 Feb 14.

Cambridge Endometriosis and Endoscopic Surgery Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.

Leiomyomas are the most common uterine benign tumor, and their malignant counterpart leiomyosarcomas are extremely rare. Despite this, a preoperative diagnosis could be useful for safe surgical minimally invasive management. At present, some clinical and ultrasound findings help recognizing lesions at risk of malignancy. Read More

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February 2022

Massive swelling of the thyroid in a young patient.

Cytopathology 2022 Jul 16;33(4):553-555. Epub 2022 Mar 16.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Extraskeletal Ewing sarcoma (EES) in the thyroid is extremely rare. This report describes a rare case of EES in thyroid gland in an 18 year female, diagnosed on fine needle aspiration cytology (FNAC). Read More

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An exceptionally rare case of metastatic osteoclast-like giant cell-rich variant of anaplastic thyroid carcinoma: A diagnostic challenge.

Cytopathology 2022 05 6;33(3):380-383. Epub 2022 Feb 6.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Osteoclast-like giant cell-rich variant of anaplastic thyroid carcinoma is extremely uncommon. In this paper we describe one such case in a 50 year-old male. The patient presented with enlarged cervical lymph node after initial total thyroidectomy. Read More

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Diabetic Mastopathy. Review of Diagnostic Methods and Therapeutic Options.

Int J Environ Res Public Health 2021 12 31;19(1). Epub 2021 Dec 31.

1st Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-059 Lublin, Poland.

Diabetic mastopathy is a rare breast condition that may occur in insulin-treated men and women of any age. The etiology is still unclear; however, the autoimmunological background of the disease is highly suspected. The changes in diabetic mastopathy may mimic breast cancer; therefore, its diagnostic process is demanding, and treatment options are not clear and limited. Read More

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December 2021

The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis.

PLoS One 2022 5;17(1):e0262257. Epub 2022 Jan 5.

Department of Gynecology and Obstetrics, University Hospital Leipzig, Leipzig, Germany.

Cervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could have a prognostic and predictive value for patients' outcome and the knowledge of these histologic characteristics may influence clinical decision making. However, studies evaluating the diagnostic value of various biopsy techniques regarding these parameters of cervical cancer are scarce. Read More

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February 2022

The Role of Ultrasound Guided Sampling Procedures in the Diagnosis of Pelvic Masses: A Narrative Review of the Literature.

Diagnostics (Basel) 2021 Nov 26;11(12). Epub 2021 Nov 26.

Obstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.

Ultrasound-guided sampling methods are usually minimally invasive techniques applied to obtain cytological specimens or tissue samples, mainly used for the diagnosis of different types of tumors. The main benefits of ultrasound guidance is its availability. It offers high flexibility in the choice of sampling approach (transabdominal, transvaginal, and transrectal) and short duration of procedure. Read More

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November 2021

Benign metastasizing leiomyoma, a rare imposter of metastatic cervical cancer.

Gynecol Oncol Rep 2021 Nov 20;38:100893. Epub 2021 Nov 20.

Elson S Floyd College of Medicine, Washington State University, Spokane, WA, United States.

Benign metastasizing leiomyoma (BML) is a rare variant of common benign smooth muscle neoplasm. We report a case of BML in a 45-year-old premenopausal woman with a significant smoking history and no previous history of cervical cancer screening. The patient presented with vaginal bleeding, abdominal pain, a necrotic mass in the vagina, and an incidental finding of diffuse pulmonary nodules on chest imaging. Read More

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November 2021

Evaluation of the Utility of Liquid-based Cytology, Cell-blocks, and Flow Cytometric Immunophenotyping on Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Samples in the Diagnosis of Sarcoidosis.

J Bronchology Interv Pulmonol 2021 Dec 6. Epub 2021 Dec 6.

Departments of Pathology Cytology and Gynecologic Pathology Pulmonary Medicine Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.

Background: There is little information on the value of different processing methods for samples obtained during endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) in suspected sarcoidosis. We evaluated the role of conventional smears, liquid-based cytology (LBC), cell-blocks and flow cytometric immunophenotyping in the diagnosis of sarcoidosis using EBUS-TBNA samples.

Methods: This was a prospective study of consecutive EBUS-TBNA samples from clinically suspected cases of sarcoidosis. Read More

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December 2021

Cytodiagnosis of giant cell tumour presenting at unusual age and site with review of literature.

Cytopathology 2022 05 7;33(3):393-396. Epub 2021 Dec 7.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Giant cell tumour (GCT), also known as osteoclastoma, is an osteolytic tumour. It involves the epiphyseal and metaphyseal regions of long bones in adults. On rare occasions, these may occur in paediatric patients, and may involve uncommon locations such as the sternum, pelvis and, particularly infrequently, rib bones. Read More

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Renal metastasis from papillary thyroid carcinoma: A diagnostic dilemma.

Cytopathology 2022 03 30;33(2):285-286. Epub 2021 Oct 30.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

In this paper, first time a rare case of solitary metastasis of papillary carcinoma of thyroid in the kidney diagnosed by fine needle aspiration cytology has been described. Read More

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Cesarean Section: A Potential and Forgotten Risk for Abdominal Wall Endometriosis.

Cureus 2021 Aug 24;13(8):e17410. Epub 2021 Aug 24.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Cesarean section endometriosis (CSE) can be caused by the iatrogenic deposition of endometrial cells, glands, and stroma during any time of the surgical procedure. It can be asymptomatic or, more frequently, resulting in chronic pain. Our article intends to provide more clinical information on CSE symptomatology, diagnosis, and preventive methods available in the literature, and discuss the malignancy transformation risk. Read More

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Antitumor activity of everolimus in recurrent metastatic endometrial cancer with deletion: a case report.

Gland Surg 2021 Aug;10(8):2585-2590

Department of Medical Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Endometrial cancer (EC) is one of the most common gynecological tumors. The first-line treatment for advanced EC is chemoradiotherapy. However, patients in poor health, such as those with intestinal obstruction, have limited tolerance for the side effects of chemoradiotherapy. Read More

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Ultrasound-guided fine needle aspiration cytology of Para-aortic lymph node metastasis in uterine cervical cancer: diagnostic accuracy and impact on clinical decision making.

BMC Cancer 2021 Aug 27;21(1):964. Epub 2021 Aug 27.

Department of Ultrasound, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), No.1 East Banshan Road, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.

Objective: The main aim of this study was to ascertain the effectiveness of ultrasound-guided fine needle aspiration cytology (US-FNAC) in the diagnosis of para-aortic lymph node (PALN) metastasis in uterine cervical cancer and to establish its potential impact on clinical therapeutic decision making.

Methods: We retrospectively reviewed clinical data from 92 patients diagnosed with cervical cancer with PALN enlargement between 2010 and 2018. Cytological results obtained with US-FNAC were classified by the same experienced cellular pathologists. Read More

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Developing dashboards for performance improvement in cytopathology.

J Am Soc Cytopathol 2021 Nov-Dec;10(6):535-542. Epub 2021 Jul 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

Introduction: Cytopathology has well-defined and objective quality metrics for monitoring the performance of cytopathologists (CPs) and cytotechnologists (CTs). We transformed these metrics into dashboards for real-time visualization and on-demand feedback.

Methods: Dashboards were constructed with data from the previous 10 calendar years using the software Tableau. Read More

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Ultrasound-guided fine needle aspiration of ovarian masses: Assessment of diagnostic accuracy and risk stratification using a categorical reporting system.

Cytopathology 2021 07 20;32(4):441-458. Epub 2021 May 20.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: The present study was undertaken to assess the accuracy of fine needle aspiration cytology (FNAC) and cell-block immunocytochemistry, and to estimate the risk of malignancy, using a categorical reporting system, in the diagnosis of ovarian masses.

Methods: This was a 5-year retrospective study of FNAs of ovarian masses. The cytological diagnoses were categorised as inadequate, non-neoplastic, benign neoplasms, indeterminate for malignancy, suspicious for malignancy and malignant neoplasms. Read More

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Ultrasound-Guided Omental Biopsy: Diagnostic Yield and Association With CT Features Based on a Single-Institution 18-Year Series.

AJR Am J Roentgenol 2021 10 14;217(4):898-906. Epub 2021 Apr 14.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252.

The greater omentum can serve as a useful target for percutaneous biopsy; in clinical practice, CT is commonly used for biopsy guidance. The purpose of this study was to evaluate the diagnostic yield of percutaneous ultrasound (US)-guided omental biopsy and to explore the association of the diagnostic yield with prebiopsy diagnostic CT findings. This retrospective study included 163 patients (120 women and 43 men; mean age, 65 ± 12 [SD] years; mean body mass index [BMI], 28. Read More

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October 2021

Assessment of risk of malignancy by application of the proposed Sydney system for classification and reporting lymph node cytopathology.

Cancer Cytopathol 2021 09 8;129(9):701-718. Epub 2021 Apr 8.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Fine-needle aspiration cytology (FNAC) is one of the most commonly used techniques for evaluating lymphadenopathy. Recently, the Sydney system was proposed for assessing the performance, classification, and reporting of lymph node (LN) cytopathology. The present study was conducted to assess the risk of malignancy associated with each of the diagnostic categories of the proposed Sydney system. Read More

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September 2021

Assessing the value of second opinion pathology review.

Int J Qual Health Care 2021 Mar;33(1)

Department of Pathology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Lab Building, Lower Level, Room L69, Milwaukee, WI 53226, USA.

Background: Second opinion review of pathology cases can identify diagnostic errors that impact patient care.

Objective: We sought out to determine discrepancy rates and clinical impact of review of pathology cases to reassess our policy of review on all second opinion cases.

Methods: All second opinion pathology cases over 1 year (2018) were retrospectively reviewed for discrepancy, multiple pathologist review and clinicopathologic features via chart and slide review. Read More

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Metastatic ovarian cancer spreading into mammary ducts mimicking an in situ component of primary breast cancer: a case report.

J Med Case Rep 2021 Feb 17;15(1):78. Epub 2021 Feb 17.

Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Accurate diagnosis of metastatic tumors in the breast is crucial because the therapeutic approach is essentially different from primary tumors. A key morphological feature of metastatic tumors is their lack of an in situ carcinoma component. Here, we present a unique case of metastatic ovarian carcinoma spreading into mammary ducts and mimicked an in situ component of primary carcinoma. Read More

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February 2021

Sentinel node mapping in endometrial cancer: Tips and tricks to improve bilateral detection rate. The sentitricks study, a monocentric experience.

Taiwan J Obstet Gynecol 2021 Jan;60(1):31-35

Department of Gynecology and Obstetrics, University of Parma, Via Gramsci, 14, 43125, Parma, Italy.

Objective: The objective of the study is to show some small tricks for bilateral sentinel lymph node (SLN) uptake in endometrial cancer.

Materials And Methods: Each step of the sentinel lymph node technique was analyzed. The cervix was exposed through the use of vaginal valves and by Martin pliers stapling of the anterior cervical lip. Read More

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January 2021

p16 immunostaining in cytology specimens: its application, expression, interpretation, and challenges.

J Am Soc Cytopathol 2021 Jul-Aug;10(4):414-422. Epub 2020 Dec 15.

Department of Pathology, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:

Introduction: p16 immunostaining is considered as a surrogate marker for human papillomavirus (HPV)-related head and neck squamous cell carcinomas (HNSCC). Herein, the utility of p16 is evaluated in cytology specimens.

Material And Methods: The electronic data of a large academic institution was searched for cytology cases accompanied by p16 (2014-2018). Read More

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January 2022

Surgical Technique for Sentinel Lymph Node Sampling in Presumed Early-stage Ovarian Cancer.

J Minim Invasive Gynecol 2021 08 30;28(8):1446. Epub 2020 Dec 30.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Jewish General Hospital (all authors); Segal Cancer Center, Lady Davis Institute of Medical Research (Drs. Matanes, Kogan, Salvador, Gotlieb, and Lau), McGill University, Montreal, Quebec, Canada. Electronic address:

Study Objective: Surgical staging for apparent early-stage ovarian cancer includes systematic pelvic and para-aortic lymph node evaluation to detect occult stage III disease [1]. Although, lymphadenectomy procedure is associated with increased duration of surgery and a 13% risk of lymphocyst formation [2]. Sentinel lymph node (SLN) biopsy is still investigational, and no standardized approach has been studied. Read More

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Breast Fine-Needle Aspiration Practice in 2019: Results of a College of American Pathologists National Survey.

Arch Pathol Lab Med 2021 07;145(7):825-833

From the Department of Pathology, Ohio State University Medical Center, Columbus (Li).

Context.—: The College of American Pathologists surveys provide national benchmarks of pathology practice for laboratories.

Objective. Read More

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Acute monocytic leukemia presenting as generalized lymphadenopathy and skin rash in a toddler: highlighting the clinicopathologic mimics.

Diagn Cytopathol 2021 Apr 23;49(4):E156-E163. Epub 2020 Oct 23.

Department of Hematology, PGIMER, Chandigarh, India.

Acute myeloid leukemia (AML) is the fifth most common malignancy in children. Extramedullary involvement in acute myeloid leukemia is rare and can be seen in soft tissues, central nervous system, skin and lymphoreticular organs. The clinical presentations can often be non-specific and hence, the diagnosis can be very challenging, especially in cases without a prior hematologic diagnosis. Read More

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Cytological diagnosis of osteosarcoma with emphasis on diagnostic pitfalls.

Cytopathology 2021 Mar 4;32(2):243-249. Epub 2020 Dec 4.

Department of Cytology and Gynecologic Pathology, PGIMER, Chandigarh, India.

Introduction: Fine needle aspiration is a well-established technique for evaluating primary and secondary bony lesions. With use in selected cases, it achieves a diagnostic yield comparable to biopsies.

Methods: Cases of osteosarcoma (OS) with available histological follow-up were retrieved over a 10-year period. Read More

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Fine-needle aspiration cytology of Bacille Calmette-Guerin adenitis: A perplexing distinct clinical entity.

Diagn Cytopathol 2021 Feb 12;49(2):226-231. Epub 2020 Sep 12.

Department of Cytology and Gynecologic Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Bacille Calmette-Guerin (BCG) adenitis is a common complication of post-BCG vaccination. Awareness of this lesser known entity in fine-needle aspiration (FNA) is important to prevent misdiagnosis.

Aim: This study described the clinical presentation, cytomorphological features and disease pattern in patients with BCG adenitis. Read More

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February 2021

Adenoid cystic carcinoma cytology: Salivary gland and nonsalivary gland.

Diagn Cytopathol 2020 Dec 18;48(12):1282-1289. Epub 2020 Aug 18.

Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objectives: Adenoid cystic carcinoma (ACCA) is an uncommon primary malignancy of salivary glands and rarely nonsalivary tissue. This study aims to evaluate the diagnostic accuracy of ACCA on fine needle aspiration (FNA) material and the associated challenges.

Methods: A search on electronic pathology database from 2006 to 2016 at The Johns Hopkins Hospital found 83 cytology specimens diagnosed as ACCA, 49 with histology follow-up. Read More

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December 2020