312 results match your criteria Gynecologic Needle Biopsy


Development of Patient-Derived Tumor Xenograft Models.

Methods Mol Biol 2019 ;1862:217-225

Gynecological Oncology, Oncology Department, LKI Leuven Cancer Institute KU Leuven-University of Leuven, Leuven, Belgium.

In spite of the latest advancements in understanding cancer development and progression, drugs successful in preclinical testing often fail upon reaching phase III clinical trials. A reason for this is the use of inappropriate preclinical models that do not preserve tumor heterogeneity. Although used for decades, cell cultures derived from patients substantially deviate from their original biopsy upon culturing; moreover, they cannot predict the response of an organism as a whole. Read More

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http://dx.doi.org/10.1007/978-1-4939-8769-6_15DOI Listing
January 2019
1 Read

Factors affecting pain during outpatient clinic based surgical procedures in gynecologic oncology.

Medicine (Baltimore) 2018 Aug;97(31):e11721

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-Si, Gyeonggi-Do.

Colposcopy-directed punch biopsy (punch biopsy) and endocervical curettage (ECC) are accompanied by considerable pain. However, many physicians perform these procedures without adequate pain management. Therefore, identification of factors affecting pain experienced during the procedures may encourage physician effort in selective pain management. Read More

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http://dx.doi.org/10.1097/MD.0000000000011721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081132PMC
August 2018
14 Reads
5.720 Impact Factor

Pelvic and pulmonary benign metastasizing leiomyoma: A case report.

Case Rep Womens Health 2018 Apr 31;18:e00061. Epub 2018 Mar 31.

Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Seven years after she had a total abdominal hysterectomy for benign leiomyomas, a 46-year-old woman presented with a pelvic mass and multiple pulmonary nodules. She underwent resection of the mass and core needle biopsy of a pulmonary lesion. Histopathologic analysis revealed that both the pelvic and the pulmonary lesions were consistent with benign leiomyomas. Read More

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http://dx.doi.org/10.1016/j.crwh.2018.e00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960028PMC
April 2018
5 Reads

Ultrasound-guided follicle aspiration at time of laparotomy in a patient with Mayer-Rokitansky-Küster-Hauser syndrome.

Fertil Steril 2018 05;109(5):940

Department of Reproductive Endocrinology and Infertility, Washington University, St. Louis, Missouri.

Objective: To demonstrate a unique case of direct ultrasound-guided follicle aspiration at time of a laparotomy in a patient with Mayer-Rokitansky-Küster-Hauser Syndrome.

Design: Video presentation.

Setting: Academic fertility center PATIENT(S): A 32-year-old gravida 0 with Mayer-Rokitansky-Küster-Hauser Syndrome and bilateral ovarian masses presented as a fertility preservation consult from gynecologic oncology due to the possibility of bilateral oophorectomy. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.02.007DOI Listing
May 2018
11 Reads

Sarcoid-Like Mediastinal Lymphadenopathy in Gynecologic Malignancy.

Pulm Med 2018 14;2018:5141575. Epub 2018 Feb 14.

Pulmonary-Critical Care Medicine, Abington Jefferson Health, Abington, PA, USA.

Noncaseating granulomas are seen surrounding tumors with varying frequency, possibly as part of an immune response to tumor cells. However, data about the association of sarcoid with gynecologic malignancy is sparse. We performed a search of our institutional database for all EBUS-TBNA biopsies conducted within the past five years that revealed granulomatous inflammation. Read More

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https://www.hindawi.com/journals/pm/2018/5141575/
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http://dx.doi.org/10.1155/2018/5141575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832114PMC
January 2019
5 Reads

Suitability of the Cellient cell block method for diagnosing soft tissue and bone tumors.

Diagn Cytopathol 2018 Apr 10;46(4):299-305. Epub 2018 Jan 10.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, RB Groningen, 9700, The Netherlands.

Background: The diagnosis of tumors of soft tissue and bone (STB) heavily relies on histological biopsies, whereas cytology is not widely used. Cellient cell blocks often contain small tissue fragments. In addition to Hematoxylin and Eosin (H&E) interpretation of histological features, immunohistochemistry (IHC) can be applied after optimization of protocols. Read More

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http://doi.wiley.com/10.1002/dc.23887
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http://dx.doi.org/10.1002/dc.23887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888188PMC
April 2018
13 Reads

Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device.

Obstet Gynecol 2018 01;131(1):109-116

Department of Gynecologic Oncology and Reproductive Medicine and the Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas.

Objective: To assess efficacy of the levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of complex atypical hyperplasia or low-grade endometrial cancer.

Methods: This retrospective case series included all patients treated with the LNG-IUD for complex atypical hyperplasia or early-grade endometrial cancer from January 2003 to June 2013. Response rates were calculated and the association of response with clinicopathologic factors, including age, body mass index, and uterine size, was determined. Read More

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http://dx.doi.org/10.1097/AOG.0000000000002390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739955PMC
January 2018
19 Reads

Cytomorphologic features of metastatic endometrioid carcinoma by fine needle aspiration.

Diagn Cytopathol 2018 Feb 4;46(2):105-110. Epub 2017 Nov 4.

Department of Pathology, The University of Chicago, Chicago, Illinois.

Background: Although metastatic disease is commonly seen in high grade carcinomas of gynecologic origin, it also occurs in low to intermediate grade endometrioid carcinomas (LGEMCAs), and may even be the primary presentation of disease. Tissue confirmation is necessary to guide therapy, but performing biopsies might not always be feasible or practical. In such instances, fine needle aspiration (FNA) is a safe and efficient alternative. Read More

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http://dx.doi.org/10.1002/dc.23855DOI Listing
February 2018
9 Reads

Three-year cytohistological correlation of salivary gland FNA cytology at a tertiary center with the application of the Milan system for risk stratification.

Cancer Cytopathol 2017 Oct 7;125(10):767-775. Epub 2017 Aug 7.

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Fine-needle aspiration (FNA) cytology of salivary glands is a well-established technique that plays a critical role in the preoperative diagnosis of lesions. A risk stratification of FNA diagnostic categories has been recently proposed to be useful in reporting. The aims of this study were to evaluate the diagnostic accuracy of salivary gland FNA and to apply the proposed Milan system for reporting salivary gland lesions. Read More

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http://dx.doi.org/10.1002/cncy.21900DOI Listing
October 2017
55 Reads

Laparoscopic Minimally Invasive Approach to Sentinel Lymph Node Mapping of the Ovary Using the Near-infrared Fluorescent S1 HD Pinpoint System with Indocyanine Green Dye.

J Minim Invasive Gynecol 2018 Feb 29;25(2):336-337. Epub 2017 Jul 29.

Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Study Objective: To show a novel minimally invasive approach to sentinel lymph node (SLN) detection of the ovary with near-infrared-guided surgery using indocyanine green (ICG).

Design: A step by step description of the technique with video and figures (educational video).

Setting: The standard surgical staging of early-stage I-II ovarian cancer includes systematic pelvic and aortic lymphadenectomy even in the absence of clear evidence regarding the survival benefits associated with comprehensive retroperitoneal staging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15534650173040
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http://dx.doi.org/10.1016/j.jmig.2017.07.018DOI Listing
February 2018
23 Reads

The evolving role of cytopathology in the era of neoadjuvant chemotherapy for the accurate pathologic diagnosis of epithelial ovarian cancer.

Authors:
Elise N Everett

Cancer Cytopathol 2017 10 31;125(10):743-744. Epub 2017 Jul 31.

Associate Professor of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Larner College of Medicine at the University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1002/cncy.21894DOI Listing
October 2017
2 Reads

Fine-needle aspiration cytology in primary cutaneous tumors.

Diagn Cytopathol 2017 Aug 4;45(8):681-688. Epub 2017 May 4.

Department of Cytology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Fine-needle aspiration biopsy (FNAB) is occasionally used in the evaluation of primary skin tumors. However, in routine evaluation of any soft tissue swelling we encounter the cases of skin lesions. It is essential to know FNAB features of skin lesions. Read More

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http://dx.doi.org/10.1002/dc.23741DOI Listing
August 2017
23 Reads

Impact of Preoperative Breast MR Imaging and MR-guided Surgery on Diagnosis and Surgical Outcome of Women with Invasive Breast Cancer with and without DCIS Component.

Radiology 2017 09 26;284(3):645-655. Epub 2017 Apr 26.

From the Department of Diagnostic and Interventional Radiology (C.K.K., K.S., S.S.), Section of Bioinformatics, Department of Diagnostic and Interventional Radiology (H.B.), and Department of Gynecology and Gynecologic Oncology (N.M.), University of Aachen, RWTH, Pauwelsstr 30, 52074 Aachen, Germany; Department of Pathology, University of Muenster, Muenster, Germany (E.W.); and Department of Gynecology, University of Bonn, Bonn, Germany (W.K.).

Purpose To (a) compare the diagnostic accuracy of breast magnetic resonance (MR) imaging with that of conventional imaging (digital mammography and breast ultrasonography) in the identification of ductal carcinoma in situ (DCIS) components of biopsy-proven invasive breast cancer before surgery and (b) investigate the surgical outcome (positive margin rates and mastectomy rates) of women with breast cancer who underwent preoperative MR imaging combined with MR-guided needle biopsy and/or MR-guided lesion localization or bracketing where appropriate. Materials and Methods The authors performed a prospective two-center study of 593 consecutive patients with biopsy-proven invasive breast cancer who underwent breast MR imaging in addition to conventional imaging. MR-guided vacuum biopsy and MR-guided lesion bracketing were performed for DCIS components visible at MR imaging alone. Read More

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http://dx.doi.org/10.1148/radiol.2017161449DOI Listing
September 2017
17 Reads

Agreement between cytotechnologists and cytopathologists as a new measure of cytopathologist performance in gynecologic cytology.

Cancer Cytopathol 2017 Jul 27;125(7):576-580. Epub 2017 Mar 27.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Background: Although objective measures of cytotechnologist (CT) and cytopathologist (CP) performance exist, challenges remain. Two assumptions deserve examination: CPs' interpretations are correct, and CTs and CPs render interpretations independently of each other. This study presents a CT-CP interpretation comparison and provides insight into these assumptions. Read More

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http://dx.doi.org/10.1002/cncy.21856DOI Listing
July 2017
20 Reads

Changing Trends and Practices in Cytopathology.

Acta Cytol 2017 22;61(2):91-95. Epub 2017 Mar 22.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.

Objective: To explore the current and anticipated changes in the practice of cytopathology.

Study Design: The present review is based on a review of recent literature and an evaluation of the authors' personal experiences.

Results And Conclusion: In recent years the practice of cytopathology, nationwide and in our institute, has witnessed a major change affecting gynecologic and nongynecologic cytology. Read More

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http://dx.doi.org/10.1159/000460236DOI Listing
May 2017
10 Reads

Needleoscopic Conservative Staging of Borderline Ovarian Tumor.

J Minim Invasive Gynecol 2017 May - Jun;24(4):529-530. Epub 2016 Oct 27.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.

Study Objective: To investigate the safety and technical feasibility of needleoscopic fertility-sparing staging of borderline ovarian tumors.

Design: Video article and review of the literature (Canadian Task Force classification Level III).

Setting: This 29-year-old woman had a right ovarian cyst suspicious for borderline ovarian tumor on preoperative magnetic resonance imaging and ultrasound showing the presence of a right unilocular ovarian cyst with a papillary projection. Read More

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http://dx.doi.org/10.1016/j.jmig.2016.10.009DOI Listing
December 2017
7 Reads

Endometriosis-associated clear cell carcinoma arising in caesarean section scar: a case report and review of the literature.

World J Surg Oncol 2016 Dec 3;14(1):300. Epub 2016 Dec 3.

Department Pathology, Catholic University, Rome, Italy.

Background: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar.

Case Presentation: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10. Read More

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http://dx.doi.org/10.1186/s12957-016-1054-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135835PMC
December 2016
27 Reads

Successful application of endoscopic ultrasound-guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts: a pilot study.

Endoscopy 2016 Nov 14;48(11):1016-1022. Epub 2016 Sep 14.

Laboratory of Gynecologic Oncology, Department of Oncology, University of Leuven, Leuven, Belgium.

Typically, pancreatic patient-derived tumor xenografts (PDXs) are established by transplanting large tumor biopsies obtained through invasive surgery approaches into immunocompromised mice. We aimed to develop pancreatic PDXs by transplanting tumor tissue acquired by endoscopic ultrasound (EUS)-guided fine needle biopsies (FNB), assess take rates compared to surgery-derived PDXs, and demonstrate the histological and genetic resemblance to the original tumor. Biopsies of untreated pancreatic carcinoma were collected at surgery and during EUS and processed to generate PDXs. Read More

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http://dx.doi.org/10.1055/s-0042-113597DOI Listing
November 2016
15 Reads

Pregnancy-associated Breast Cancer.

Authors:
Ashley S Case

Clin Obstet Gynecol 2016 12;59(4):779-788

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mountain Area Health Education Center, Hope Women's Cancer Center, Asheville, North Carolina.

Breast cancer is one of the most common malignancies affecting pregnancy. Pregnancy-associated breast cancer refers to breast cancer that is diagnosed during pregnancy or within the first postpartum year. The incidence is increasing as more women delay childbearing. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000235DOI Listing
December 2016
7 Reads

Sensitivity of Follow-Up Methods in Patients After Fertility-Sparing Surgery for Cervical Cancers.

Int J Gynecol Cancer 2017 01;27(1):147-153

*1st Faculty of Medicine, Department of Gynecology and Obstetrics, Gynecologic Oncology Centre, Charles University and General University Hospital in Prague; and †Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic.

Objective: The aim of our study was to compare the sensitivity of various methods and their combinations in the follow-up of patients with cervical cancer after fertility-sparing surgery (FSS).

Methods: Included were women with cervical cancer in stages IA2 to IB2 who underwent FSS, which includes pelvic lymphadenectomy, sentinel lymph node biopsy, abdominal radical trachelectomy, vaginal trachelectomy, or needle conization. Follow-up visits were scheduled at 3-month intervals and included symptom-oriented discussion, gynecological and physical examination, colposcopy, Papanicolaou test, human papillomavirus (HPV) DNA test, and ultrasound examination. Read More

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http://dx.doi.org/10.1097/IGC.0000000000000835DOI Listing
January 2017
11 Reads

Percutaneous image-guided pelvic procedures in women with gynecologic cancers: utilization, complications, and impact on patient management.

Abdom Radiol (NY) 2016 12;41(12):2460-2465

Department of Radiology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5030, USA.

Purpose: Image-guided percutaneous pelvic procedures often play an important role in the management of women with gynecologic cancers. The purpose of this study is to evaluate the utilization of and indications for these procedures, and quantify their impact on patient management.

Methods: IRB-approved retrospective record review of percutaneous pelvic procedures requested by gynecologic oncology, 2005 to 2015. Read More

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http://dx.doi.org/10.1007/s00261-016-0882-9DOI Listing
December 2016
7 Reads

Vaginal fine-needle aspiration: A useful alternative to biopsy.

Diagn Cytopathol 2016 Aug 24;44(8):665-9. Epub 2016 May 24.

Rush University Medical Center, Chicago, Illinois.

Background: Vaginal fine-needle aspiration (FNA) is infrequently performed to assess palpable lesions. We perform the first multi-institutional study to evaluate this procedure.

Methods: We retrospectively reviewed vaginal FNAs performed at two institutions for the past 27 years. Read More

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http://dx.doi.org/10.1002/dc.23504DOI Listing
August 2016
10 Reads

Transvaginal Ultrasound-Guided Biopsy of Deep Pelvic Masses: How We Do It.

J Ultrasound Med 2016 Jun 18;35(6):1113-22. Epub 2016 Apr 18.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, California USA.

The purpose of this review is to discuss the rationale and indications for transvaginal ultrasound-guided biopsy. Transvaginal ultrasound-guided biopsy can be a helpful tool for diagnosis and treatment planning in the evaluation of pelvic masses, particularly when the anatomy precludes a transabdominal or posterior transgluteal percutaneous biopsy approach. A step-by-step summary of the technique with preprocedure and postprocedure considerations is included. Read More

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http://dx.doi.org/10.7863/ultra.15.08002DOI Listing
June 2016
6 Reads

Management of Endometrial Hyperplasia With a Levonorgestrel-Releasing Intrauterine System: A Korean Gynecologic-Oncology Group Study.

Int J Gynecol Cancer 2016 May;26(4):711-5

*Departments of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University; †Seoul National University College of Medicine, Seoul; ‡Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan; §Chonnam National University Medical School, Gwangju; ∥Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul; ¶Gyeongsang National University School of Medicine, Jinju,; #Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul; **Inha University College of Medicine, Incheon; ††CHA Bundang Medical Center, CHA University, Bundang; ‡‡Ajou University School of Medicine, Suwon; §§Sanggye Paik Hospital, Inje University College of Medicine; and ∥∥Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Objective: The aim of the study was to evaluate the efficacy of the levonorgestrel intrauterine system (LNG-IUS) for treatment of endometrial hyperplasia (EH).

Methods: A prospective multicenter study was conducted from November 2010 to March 2014. Patients with histologically confirmed EH were treated with LNG-IUS. Read More

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http://dx.doi.org/10.1097/IGC.0000000000000669DOI Listing
May 2016
17 Reads

The Utility of Core Needle Biopsy and Fine-Needle Aspiration in the Workup of Tumors of Suspected Müllerian Origin.

Acta Cytol 2015 11;59(6):465-73. Epub 2016 Feb 11.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Tex., USA.

Objectives: Core needle biopsy (CNB) and fine-needle aspiration (FNA) for tumors of suspected Müllerian origin may prevent unnecessary laparotomies and allow patients the benefit of neoadjuvant chemotherapy. An assessment of the utility and limitations of CNB/FNA, with incorporation of current immunohistochemistry, is needed.

Study Design: Two hundred nineteen female patients with CNB/FNA of the omentum, pelvis, abdomen, adnexa, ovary, uterus, and fallopian tube were identified. Read More

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http://dx.doi.org/10.1159/000443517DOI Listing
July 2016
16 Reads

Comparison of EASYPREP(®) and SurePath(®) in thyroid fine-needle aspiration.

Diagn Cytopathol 2016 Apr 5;44(4):283-90. Epub 2016 Feb 5.

Department of Hospital Pathology, the Catholic University of Korea, Seoul, Republic of Korea.

Background: While fine-needle aspiration cytology (FNAC) using conventional smear has been widely accepted as the primary diagnostic tool for thyroid lesions, liquid-based preparations (LBPs) are increasingly replacing it. A new automated LBP method, EASYPREP(®) (EP), was recently introduced and has shown relevant diagnostic efficacy in gynecologic samples. We compared the diagnostic utility of EP and SurePath(®) (SP), a more widely established LBP method, in thyroid FNAC. Read More

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http://doi.wiley.com/10.1002/dc.23438
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http://dx.doi.org/10.1002/dc.23438DOI Listing
April 2016
14 Reads

Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative.

Cancer 2016 Jan 20;122(2):230-7. Epub 2015 Oct 20.

Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts.

Background: There is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy is standard except for stage I, grade 1 disease, whereas surgery alone is standard in pediatric patients. To determine the role of chemotherapy, a pooled analysis of pediatric and adult clinical trials was conducted. Read More

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http://dx.doi.org/10.1002/cncr.29732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134834PMC
January 2016
39 Reads

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection.

J Vis Exp 2015 Sep 21(103). Epub 2015 Sep 21.

Department of Veterinary and Biomedical Sciences, Penn State University.

Single institution and population-based studies highlight that infectious complications following transrectal ultrasound guided prostate needle biopsy (TRUS PNB) are increasing. Such infections are largely attributable to quinolone resistant microorganisms which colonize the rectal vault and are translocated into the bloodstream during the biopsy procedure. A povidone iodine rectal preparation (PIRP) at time of biopsy is a simple, reproducible method to reduce rectal microorganism colony counts and therefore resultant infections following TRUS PNB. Read More

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http://dx.doi.org/10.3791/52670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692615PMC
September 2015
5 Reads

Management of Vulvar Cancer.

Rev Recent Clin Trials 2015 ;10(4):282-8

Department of Obstetrics & Gynecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi 110095.

Vulvar cancer is an uncommon malignancy and accounts for around 5% of all gynecologic cancers. Incidence rates have increased for young adults and may be linked to increasing HPV prevalence. Treatment of vulvar cancer has evolved from 'en-bloc' surgery with high morbidity to more conservative approaches without compromising oncological safety. Read More

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August 2016
6 Reads

Management of Vaginal Cancer.

Rev Recent Clin Trials 2015 ;10(4):289-97

BIMR Oncology Centre, BIMR Hospitals, Gwalior (M.P.), India.

Context: Vaginal cancer is a rare gynecologic cancer with very little documentation.

Objective: Literature search to have useful information for the management of vaginal cancer and share.

Material Methods: We have searched the PUBMED database, Google search engine and other database. Read More

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August 2016
29 Reads

Optimizing Strategies for Sentinel Lymph Node Mapping in Early-Stage Cervical and Endometrial Cancer: Comparison of Real-Time Fluorescence With Indocyanine Green and Methylene Blue.

Int J Gynecol Cancer 2015 Oct;25(8):1513-8

*Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, San Gerardo Hospital; and †University of Milano-Bicocca, Monza, Italy.

Objective: This retrospective study aimed to compare the sentinel lymph node (SLN) mapping results of methylene blue (MB) and indocyanine green (ICG) in women with early-stage endometrial or cervical cancer.

Methods: From August 2011 to March 2015, all consecutive patients with stage I endometrial or cervical cancer who underwent SLN mapping with intracervical injection of MB or ICG using a 22-gauge spinal needle were included in the study. Radical or simple hysterectomy with bilateral pelvic and/or aortic lymphadenectomy was performed after SLN mapping. Read More

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http://dx.doi.org/10.1097/IGC.0000000000000526DOI Listing
October 2015
9 Reads

Uterine papillary serous carcinoma pre-operatively diagnosed as endometrioid carcinoma: Is omentectomy necessary?

Aust N Z J Obstet Gynaecol 2015 Oct 31;55(5):498-502. Epub 2015 Jul 31.

The Gynecologic Oncology Division, Rabin Medical Center, Petach Tikva, Israel.

Background: Uterine papillary serous carcinoma (UPSC) is a relatively rare but aggressive uterine malignancy comprising approximately 10% of endometrial cancers. Many women pre-operatively misdiagnosed as having endometrioid carcinoma have ultimately UPSC on final pathology. These women receive inadequate surgical staging without omentectomy. Read More

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http://dx.doi.org/10.1111/ajo.12377DOI Listing
October 2015
9 Reads

Comparison of diagnostic accuracy between endometrial curettage and pipelle aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group Study (KGOG 2019).

Jpn J Clin Oncol 2015 Oct 22;45(10):980-2. Epub 2015 Jul 22.

Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with dilatation and curettage in patients treated with progestin for endometrial hyperplasia. For conservative treatment of endometrial hyperplasia, orally administered progestins are most commonly used method with various treatment regimens and more recently, the levonorgestrel-releasing intrauterine system also has been used successfully to treat endometrial hyperplasia. However, there is no report about the accuracy of endometrial sampling during hormonal treatment for follow-up evaluation of endometrial hyperplasia. Read More

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http://dx.doi.org/10.1093/jjco/hyv106DOI Listing
October 2015
17 Reads

The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?

Expert Rev Anticancer Ther 2015 ;15(8):911-21

Division of Anatomic Pathology and Histology - Università Cattolica del Sacro Cuore, "Agostino Gemelli" School of Medicine, Rome, Italy.

Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Read More

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http://dx.doi.org/10.1586/14737140.2015.1053874DOI Listing
April 2016
12 Reads

Genital involvement in pemphigus vulgaris (PV): correlation with clinical and cervicovaginal Pap smear findings.

J Am Acad Dermatol 2015 Oct 17;73(4):655-9. Epub 2015 Jul 17.

Department of Obstetrics and Gynecology, Istanbul Medeniyet University, School of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey.

Background: The frequency of genital involvement in pemphigus vulgaris (PV) has not been clearly defined.

Objectives: We sought to evaluate the frequency of cervical, vaginal, and vulvar involvement in PV and to determine their association with genital symptoms, clinical involvement, and cytological status.

Methods: The current study's sample included 34 female patients with PV. Read More

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http://dx.doi.org/10.1016/j.jaad.2015.06.057DOI Listing
October 2015
31 Reads

Solitary Fibrous Tumor of the Uterus Presenting With Lung Metastases: A Case Report.

Int J Gynecol Pathol 2016 Jan;35(1):25-9

Division of Women's and Perinatal Pathology (K.C.S., M.R.N., B.E.H.) Department of Obstetrics and Gynecology, Division of Gynecologic Pathology, Brigham and Women's Hospital (K.M.E., M.G.M.) Department of Medical Oncology, Dana-Farber Cancer Institute (S.C., S.G.), Boston, Massachusetts.

We describe the case of an 81-yr-old woman who presented with bilateral pulmonary nodules in the setting of a large uterine mass, concerning for a gynecologic malignancy such as leiomyosarcoma. However, fine-needle aspiration of a lung nodule revealed a spindle cell neoplasm consistent with solitary fibrous tumor (SFT), a rare mesenchymal neoplasm characterized by a patternless architecture of spindle cells and branching ectatic vessels. Total abdominal hysterectomy demonstrated a primary SFT of the uterus. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000197DOI Listing
January 2016
11 Reads

Low-grade fibromatosis-like spindle cell carcinoma of the breast.

Arch Pathol Lab Med 2015 Apr;139(4):552-7

From the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Dwyer); and the Division of Breast and Gynecologic Pathology, Department of Pathology, University of Pittsburgh, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Clark).

Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Read More

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http://jcp.bmj.com/content/early/2015/02/23/jclinpath-2014-2
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http://www.archivesofpathology.org/doi/10.5858/arpa.2013-055
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http://dx.doi.org/10.5858/arpa.2013-0555-RSDOI Listing
April 2015
6 Reads

Endometriosis node in gynaecologic scars: a study of 17 patients and the diagnostic considerations in clinical experience in tertiary care center.

BMC Womens Health 2015 18;15:13. Epub 2015 Feb 18.

Endometriosis Unit, Universitary Hospital, 12 de Octubre, Madrid, Spain,

Background: Endometriosis nodes are observed in extra pelvic locations, particularly in gynaecological scars, with the abdominal wall being one of the most frequent locations. The main objective of the study is to review patient characteristics of cases of endometriosis nodes in gynaecological scars.

Methods: A retrospective, observational and descriptive study with a cohort of patients from Hospital 12 de Octubre was conducted from January 2000 to January 2012. Read More

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http://dx.doi.org/10.1186/s12905-015-0170-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337097PMC
December 2015
10 Reads

Ovarian Malignancy Probability Score (OMPS) for appropriate referral of adnexal masses.

Asian Pac J Cancer Prev 2014 ;15(20):8647-50

Department of Gynecology-Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail :

Background: Ovarian cancer is the most common cancer cause of gynecologic cancer deaths. In order to increase the likelihood of patient survival through primary operation by gyneco-oncologists, an appropriate algorithm for referral is considered here.

Materials And Methods: Suspicious adnexal mass cases including ovarian malignancy probability score-1 (OMPS1) scores between 2. Read More

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July 2015
5 Reads

Role of polymerase chain reaction in breast tuberculosis.

Breast Dis 2015 ;35(2):129-32

Department of Cytopathology and Gynecologic Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Breast tuberculosis (TB) is an uncommon condition even in endemic countries. Breast abscess is usually seen in young females. PCR helps in such challenging cases to clinch the correct diagnosis. Read More

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http://dx.doi.org/10.3233/BD-140390DOI Listing
July 2016
11 Reads

Image-guided ovarian mass biopsy: efficacy and safety.

J Vasc Interv Radiol 2014 Dec 18;25(12):1922-1927.e1. Epub 2014 Sep 18.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 25 New Chardon St., Suite 501, Boston, MA 02114.

Purpose: Image-guided needle biopsy represents a minimally invasive method for pathologic diagnosis of a mass. This study evaluates the diagnostic yield, accuracy, and safety of ovarian mass biopsy with combined core and fine-needle technique.

Materials And Methods: Medical records of all women at least 18 years of age, referred from gynecologic oncology, who underwent image-guided ovarian mass biopsy from 2001 through 2011 were reviewed. Read More

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http://dx.doi.org/10.1016/j.jvir.2014.08.009DOI Listing
December 2014
13 Reads

Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.

J Am Acad Dermatol 2014 Oct 4;71(4):698-707. Epub 2014 Jul 4.

General Gynecology Practice, Mürzzuschlag, Austria.

Background: Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented.

Objectives: We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs.

Methods: Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomavirus DNA, p16ink4a, and p53 expression. Read More

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http://dx.doi.org/10.1016/j.jaad.2014.05.057DOI Listing
October 2014
8 Reads

Reproducibility of cervical intraepithelial neoplasia diagnosis on histological review of cervical punch biopsies from a visual inspection with acetic acid and HPV detection-based screening program.

Int J Gynaecol Obstet 2014 Sep 29;126(3):227-31. Epub 2014 May 29.

Department of Gynecologic Oncology, Chittaranjan National Cancer Institute, Kolkata, India. Electronic address:

Objective: To assess the reproducibility of cervical intraepithelial neoplasia (CIN) diagnosis in a visual inspection with acetic acid (VIA) and HPV detection-based screening program, and to correlate CIN diagnosis with oncogenic HPV status.

Methods: A total of 9630 women were screened by VIA and high-risk HPV detection at community outreach clinics in India between June 2011 and June 2012. Biopsies obtained from women who were positive on either test were reviewed by two pathologists blinded to the histological diagnoses originally made by pathologists working at the Chittaranjan National Cancer Institute. Read More

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http://dx.doi.org/10.1016/j.ijgo.2014.03.037DOI Listing
September 2014
17 Reads
1.563 Impact Factor

EUS-guided fine needle tissue acquisition for the diagnosis of pleural metastases from endometrial cancer.

Eur Rev Med Pharmacol Sci 2014 ;18(9):1379-82

Digestive Endoscopy Unit, Thoracic Surgery, Division of Gynecologic Oncology, and Institute of Pathology, Catholic University of the Sacred Heart, School of Medicine, Rome, Italy.

Transesophageal EUS-FNA have become a useful tool in the evaluation of the mediastinum, especially during the staging work-up examination of patients with non-small-cell lung cancer (NSCLC) or other malignancies. We report a challenging case of a 53 years-old woman with an endometrial adenocarcinoma who subsequently presented with right pleural effusion, diffuse pleural thickening with few pleural lesions. The patient referred a long history of exposure to amiantum, this posing a differential diagnosis between primary pleural tumour (mesothelioma) and neoplastic pleural localization of the endometrial cancer. Read More

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April 2015
5 Reads

Class II versus Class III radical hysterectomy in early cervical cancer: an observational study in a tertiary center.

Eur J Surg Oncol 2014 Jul 25;40(7):883-90. Epub 2014 Feb 25.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Aims: The purpose of this observational study was to evaluate disease free survival (DFS), overall survival (OS), and local recurrence rate (LRR) in patients submitted to Class II RH compared with Class III RH in early FIGO stage cervical cancer (ECC).

Materials And Methods: We investigated 127 patients with CC admitted to the National Cancer Institute of Milan from June 2001 to October 2011 treated with Class II RH, and compared them with 202 patients operated with Class III RH between March 1980 and March 2001. A total of 329 patients were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983140030
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http://dx.doi.org/10.1016/j.ejso.2014.02.229DOI Listing
July 2014
4 Reads

Design of a prognostic score model for nasopharyngeal carcinoma.

Head Neck 2015 May 12;37(5):624-9. Epub 2014 Jul 12.

Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China; Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

Background: The purpose of this analysis was to create a prognostic score model for newly diagnosed nasopharyngeal carcinoma (NPC) which has not been created before.

Methods: We retrospectively reviewed the medical records of 419 patients with newly diagnosed, nondisseminated, and biopsy proven NPC.

Results: Independent prognostic factors included age >45, stage III/IV, antienzyme rate of Epstein-Barr virus DNase-specific neutralizing antibody (AER) >58%, and absolute neutrophil count (ANC) >4. Read More

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http://dx.doi.org/10.1002/hed.23642DOI Listing
May 2015
4 Reads

Ovarian cancer initially presenting with isolated ipsilateral superficial inguinal lymph node metastasis: a case study and review of the literature.

J Ovarian Res 2014 Feb 10;7:20. Epub 2014 Feb 10.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Isolated superficial inguinal metastases without any extended intra-abdominal spread is a rare event in patients with ovarian carcinoma. Here we report an isolated superficial inguinal metastasis in a patient with primary ovarian cancer. A 54-year-old Chinese patient with primary ovarian cancer, had an isolated painless enlarged right groin swelling (3×2cm) as the only manifestation, preoperative pathology confirmed metastatic adenocarcinoma. Read More

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http://dx.doi.org/10.1186/1757-2215-7-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926675PMC
February 2014
6 Reads

Making chorionic villus sampling painless for both the patient and the physician.

J Ultrasound Med 2014 Feb;33(2):355-7

The George Washington University, 2150 Pennsylvania Ave NW, Floor 6A, Washington, DC, 20037 USA.

Currently, in common practice, no pain control is provided to the patient undergoing transvaginal chorionic villus sampling (CVS). Chorionic villus sampling is an invasive procedure involving an 18-gauge needle stick through the abdomen or passage of a suction catheter through the cervix. Furthermore, CVS is a mechanically difficult procedure for the clinician and requires considerable skill and training. Read More

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http://dx.doi.org/10.7863/ultra.33.2.355DOI Listing
February 2014
6 Reads

Sonographically guided core biopsy: a minimally invasive procedure for managing adnexal masses.

J Ultrasound Med 2013 Nov;32(11):2023-7

Department of Obstetrics and Gynecology, Eskisehir Osmangazi University School of Medicine, 26100 Eskisehir, Turkey.

Objectives: We hypothesized that sonographically guided core biopsy is an effective method for the differential diagnosis of adnexal masses and evaluated patients who underwent core biopsies in our gynecologic oncology department.

Methods: We reviewed the medical records of 55 patients who underwent sonographically guided core biopsies in our gynecologic oncology department between 2010 and 2013. Patients with suspected ovarian malignancies who were unsuitable for optimal debulking surgery and patients at risk for higher morbidity and mortality because of a poor performance status, suspected nongynecologic tumors, and peritoneal tuberculosis were indicated for sonographically guided biopsy. Read More

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http://dx.doi.org/10.7863/ultra.32.11.2023DOI Listing
November 2013
20 Reads

Feasibility and optimal dosage of indocyanine green fluorescence for sentinel lymph node detection using robotic single-site instrumentation: preclinical study.

J Minim Invasive Gynecol 2013 Sep-Oct;20(5):691-6

Division of Gynecologic Oncology, Cleveland Clinic, Cleveland, Ohio.

The present study was performed to determine the optimal dosage of indocyanine green (ICG) to accurately differentiate the sentinel node from surrounding tissue and then to test this dosage using novel single-port robotic instrumentation. The study was performed in healthy female pigs. After induction of anesthesia, all pigs underwent exploratory laparotomy, dissection of the bladder, and colpotomy to reveal the cervical os. Read More

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http://dx.doi.org/10.1016/j.jmig.2013.03.013DOI Listing
May 2014
8 Reads