46,618 results match your criteria Gynecologic Myomectomy


Extent of Lymphadenectomy and Postoperative Major Complications Among Women with Endometrial Cancer Treated with Minimally Invasive Surgery.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chicago, IL, USA; Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, IL.

Background: In patients with endometrial cancer sentinel lymphadenectomy is used to accurately prognosticate extent of disease and has been proposed as a method to decrease the incidence of medical and surgical complications associated with more extensive lymphadenectomy. It is unknown if patients who undergo traditional lymphadenectomy experience major postoperative complications at the same rates as those who undergo sentinel lymphadenectomy or those who do not undergo lymphadenectomy.

Objective: To compare the incidence of major postoperative complications among endometrial cancer patients undergoing total laparoscopic hysterectomy with traditional lymphadenectomy versus sentinel or no lymphadenectomy. Read More

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December 2018
2 Reads

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

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December 2018
2 Reads

The incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection.

Authors:
Zhe Li Lei Li

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No 1, Dongcheng District, Beijing, China.

Objective: To investigate the incidence and predictors of gynecologic malignancies among postmenopausal patients with endometrial fluid collection (EFC).

Methods: All patients with EFC diagnosed by transvaginal sonography (TVS) were retrospectively reviewed if they had undergone biopsy of the endometrium from January 2008 to January 2016 in a tertiary teaching hospital. Follow-up ended in June 2017. Read More

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December 2018

Response to "surgical management of cervical cancer by laparoscopy or laparotomy".

Gynecol Oncol Rep 2019 Feb 20;27:6-7. Epub 2018 Nov 20.

Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph's Hospital Phoenix, AZ, United States.

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February 2019
3 Reads

A randomized phase II study of letrozole vs. observation in patients with newly diagnosed uterine leiomyosarcoma (uLMS).

Gynecol Oncol Rep 2019 Feb 16;27:1-4. Epub 2018 Nov 16.

Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States.

Objective: Up to 87% of uterine leiomyosarcomas have estrogen receptor positivity. There are no effective adjuvant therapies for LMS. The objective of this study was to determine the efficacy of letrozole in patients with newly diagnosed uterine leiomyosarcoma (uLMS). Read More

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February 2019

Management Of Synchronous Krukenberg Tumors From Gastric Cancer: a Single-center Experience.

J Cancer 2018 20;9(22):4197-4203. Epub 2018 Oct 20.

Department of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China.

Whether metastasectomy improves prognosis of gastric cancer patients with ovarian metastases (Krukenberg tumors) is not clear. In this study, we examined the survival benefit of metastasectomy combined with chemotherapy for treatment of synchronous Krukenberg tumors from gastric cancer and identified the prognostic factors. The subjects of this study were patients diagnosed as synchronous Krukenberg tumors of gastric origin in the period between December 2004 and December 2015. Read More

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October 2018

A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer.

Clin Proteomics 2018 1;15:38. Epub 2018 Dec 1.

1Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Box 815, 75108 Uppsala, Sweden.

Background: Over 500,000 women worldwide are diagnosed with ovarian or endometrial cancer each year. We have used a two-step strategy to identify plasma proteins that could be used to improve the diagnosis of women with an indication of gynecologic tumor and in population screening.

Methods: In the discovery step we screened 441 proteins in plasma using the proximity extension assay (PEA) and five Olink Multiplex assays (CVD II, CVD III, INF I, ONC II, NEU I) in women with ovarian cancer (n = 106), endometrial cancer (n = 74), benign ovarian tumors (n = 150) and healthy population controls (n = 399). Read More

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December 2018

Can contemporary trials of chemotherapy for HER2-negative metastatic breast cancer detect overall survival benefit?

Cancer Manag Res 2018 8;10:5423-5431. Epub 2018 Nov 8.

Department of Gynecology and Obstetrics, Erlangen University Hospital, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Purpose: Although several trials have demonstrated improved progression-free survival (PFS) with first-line regimens for HER2-negative metastatic breast cancer (mBC), overall survival (OS) benefit is elusive. We calculated required sample sizes to power for OS using published data from recent mBC trials.

Patients And Methods: Randomized superiority trials of first-line chemotherapy/targeted therapy for HER2-negative mBC including >150 patients, meeting the primary efficacy objective, and published in 2000-2018 were identified. Read More

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November 2018

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer.

Br J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and implicated in metastasis. We hypothesised that extracellular mitochondrial DNA (mtDNA) in ascites from patients with epithelial ovarian cancer (EOC) would correlate with worse outcomes. Read More

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December 2018

Treatment Outcomes and Sensitivity to Hormone Therapy of Aggressive Angiomyxoma: A Multicenter, International, Retrospective Study.

Oncologist 2018 Dec 5. Epub 2018 Dec 5.

Medical Oncology Unit 2, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

Background: Aggressive angiomyxoma (AA) is a rare, locally aggressive tumor usually arising from pelvis or perineum, with a high local-recurrence rate after complete surgery. Anecdotal responses to hormone therapy have been reported. In the present study we aimed at studying surgical treatment outcomes and sensitivity to hormone therapy of AA. Read More

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December 2018
3 Reads

STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway.

J Exp Clin Cancer Res 2018 Dec 5;37(1):305. Epub 2018 Dec 5.

Department of Gynecologic Oncology; Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.

Background: Cancer stem cells (CSCs) possess abilities of self-renewal and differentiation, have oncogenic potential and are regarded to be the source of cancer recurrence. However, the mechanism by which CSCs maintain their stemness remains largely unclear.

Methods: In this study, the cell line-derived ovarian CSCs (OCSCs), 3AO and Caov3, were enriched in serum-free medium (SFM). Read More

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December 2018
1 Read

Single-cell sequencing in ovarian cancer: a new frontier in precision medicine.

Curr Opin Obstet Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health.

Purpose Of Review: This article discusses the advances, applications and challenges of using single-cell RNA sequencing data in guiding treatment decisions for ovarian cancer.

Recent Findings: Genetic heterogeneity is a hallmark of ovarian cancer biology and underlies treatment resistance. Defining the different cell types present within a single ovarian cancer is difficult, but could ultimately lead to improvements in diagnosis and treatment. Read More

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November 2018

Molecular characterization of endometrial cancer and therapeutic implications.

Curr Opin Obstet Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota School of Medicine.

Purpose Of Review: The present article reviews genomic subtyping of endometrial carcinoma and new molecular markers with therapeutic and prognostic implications.

Recent Findings: Endometrial cancer has historically been classified through histology into endometrioid (type 1) and nonendometrioid (type II, mainly serous) subtypes. Molecular classification through genomic analysis now allows for a major advance in characterization; four distinct subgroups have been identified: polymerase ε (POLE) ultramutated, microsatellite unstable, copy number low/microsatellite stable, and copy number high/'serous-like'. Read More

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November 2018

Maternal use of hormonal contraception and risk of childhood leukaemia.

Lancet Oncol 2018 Dec;19(12):e658

Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, NY 10032, USA; Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

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December 2018

Tailoring adjuvant treatment in patients with uterine cancer.

Lancet Oncol 2018 Dec;19(12):e655

Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan 20133, Italy.

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December 2018

Dose-dense paclitaxel/carboplatin as neo-adjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer: a prospective phase II study.

Cancer Chemother Pharmacol 2018 Dec 1. Epub 2018 Dec 1.

Gynecologic Oncology Unit, Department of Women and Children Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Purpose: The role of dose-dense schedules in the neo-adjuvant treatment (NACT) of locally advanced cervical cancer (LACC) has been reported. This phase II study investigated activity of dose-dense paclitaxel/platinum before radical surgery (RS) in LACC patients.

Methods: The primary end-point was the rate of optimal pathological response (OPR: pathological complete/microscopic response). Read More

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December 2018

Comparing the effectiveness of functional electrical stimulation via sexual cognitive/behavioral therapy of pelvic floor muscles versus local injection of botulinum toxin on the sexual functioning of patients with primary vaginismus: a randomized clinical trial.

Int Urogynecol J 2018 Dec 1. Epub 2018 Dec 1.

Department of Gynecology and Obstetrics, Imam Khomeini Hospital, Fellowship in Pelvic Floor Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction And Hypothesis: Most patients suffering from vaginismus feel sinful, anxious, and incompetent, with reduced self-confidence. This study was aimed at comparing the effectiveness of the physiotherapy of pelvic floor muscles as a standard treatment and local injection of botulinum toxin on the sexual functioning of patients with primary vaginismus.

Methods: In this randomized clinical trial (RCT), the study population included women with primary vaginismus referred to the Sexual Health and Gynecologic Clinics of Imam Khomeini Hospital during 2013-2014. Read More

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December 2018
6 Reads

Quantitative accuracy of positron emission tomography/magnetic resonance and positron emission tomography/computed tomography for cervical cancer.

World J Nucl Med 2018 Oct-Dec;17(4):213-218

Biomedical Research Imaging Center, Chapel Hill, NC, USA.

With the spread of positron emission tomography/magnetic resonance (PET/MR), the question of comparability of studies becomes important. We aim to determine whether PET/MR and PET/computed tomography (PET/CT) are comparable for the case of cervical cancer. Fifteen cervical cancer patients identified by either a radiation oncologist or an oncologic surgeon had both PET/MR and PET/CT performed for initial staging within 3 weeks. Read More

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December 2018

Measuring Quality in Minimally Invasive Gynecologic Surgery: What, How, and Why?

J Minim Invasive Gynecol 2018 Nov 29. Epub 2018 Nov 29.

Kaiser Permanente Northern California, Oakland Medical Center. Electronic address:

In healthcare, the goal of maximizing value by improving the quality of care and lowering costs has been notoriously challenging to implement. The fee-for-service model in gynecology and other fields has historically promoted the reduction of non-surgical or minimally invasive approaches in favor of complex, often morbid procedures. In this paper, we seek to define quality and value in the healthcare field and describe strategies that promote quality over production. Read More

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November 2018

Author's Reply.

J Minim Invasive Gynecol 2018 Nov 29. Epub 2018 Nov 29.

Gynecologic Oncology Department of Medicine and Aging Sciences University "G. d'Annunzio"of Chieti-Pescara, Via dei Vestini 131, 66100 Chieti (CH), Italy.

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November 2018

Ovarian Cancer Cell-derived Lysophosphatidic Acid Induces Glycolytic Shift and Cancer-associated Fibroblast-Phenotype in Normal and Peritumoral Fibroblasts.

Cancer Lett 2018 Nov 29. Epub 2018 Nov 29.

Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104; Department of Cell Biology, The University of Oklahoma Health Sciences Center. Electronic address:

Cancer Associated fibroblasts (CAFs) play a critical role in cancer progression, metastasis, and therapy resistance. Molecular events that confer CAF-phenotype to predecessor-cells are not fully understood. We demonstrate here that the ovarian cancer cell-conditioned medium (OCC-CM) induces CAF-phenotype in MRC5 lung-fibroblasts and it can be mimicked by LPA. Read More

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November 2018

The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma.

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States of America. Electronic address:

Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. Read More

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November 2018
2 Reads

Outpatient desensitization of patients with moderate (high-risk) to severe platinum hypersensitivity reactions.

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, The Ohio State University College of Medicine, Columbus, OH 43220, USA. Electronic address:

Objectives: Platinum hypersensitivity reactions (HSR) affect approximately 5% of the general oncologic population. Here we report the efficacy and safety of outpatient platinum desensitization protocol (PD) in gynecologic oncology patients with moderate (high-risk) to severe platinum HSR.

Methods: This is a retrospective report of patients with gynecologic malignancies undergoing an outpatient PD for moderate (high-risk) to severe platinum HSR from 2011 to 2017. Read More

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November 2018

The current status of oocyte banks: domestic and international perspectives.

Fertil Steril 2018 Dec;110(7):1203-1208

Bioethics Institute Ghent, Department of Philosophy and Moral Sciences, Ghent University, Ghent, Belgium.

Two major breakthroughs in the field of assisted reproduction-oocyte donation and oocyte vitrification-have joined forces to create the rapidly emerging phenomenon of commercial egg banks (CEBs). In this review, we examine the history of this concept, the operational models, the geographical variations, and the benefits and pitfalls of CEBs, including the ethical and legal dilemmas arising from gamete mobility. We highlight future directions in the brave new world of third-party reproduction. Read More

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December 2018

Mesenchymal molecular subtype is an independent predictor of severe postoperative complications after primary debulking surgery for advanced ovarian cancer.

Gynecol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States. Electronic address:

Objective: To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC).

Methods: Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular subtyping were included. Residual disease (RD) status was categorized as 0, 0. Read More

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November 2018

Chemotherapy in older adult gynecologic oncology patients: Can a phenotypic frailty score predict tolerance?

Gynecol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Division of Gynecologic Oncology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: Evaluate the ability of an office-administered phenotypic frailty assessment to predict chemotherapy tolerance in older adult gynecologic oncology patients, and describe practice patterns for chemotherapy administration in this population.

Methods: Prospective, single-institution cohort study of gynecologic oncology patients 65 or older initiating chemotherapy. Phenotypic frailty testing at an office visit encompassed components of two validated frailty assessments: Fried Score (physical testing and patient response) and FRAIL Scale (patient response only). Read More

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November 2018

Smooth Muscle Cells in Pelvic Washings At Time of Benign Hysterectomy.

J Minim Invasive Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Department of Gynecologic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Study Objective: To evaluate if smooth muscle cells can be detected in pelvic washings at the time of intact hysterectomy.

Design: A multi-centered pilot cohort study (Canadian Task Force Classification of Study Design Class II-2).

Setting: Two academically affiliated tertiary referral centers. Read More

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November 2018

Impact of incidental findings in preoperative CTA imaging for autologous breast reconstruction.

J Plast Reconstr Aesthet Surg 2018 Nov 22. Epub 2018 Nov 22.

Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, 330 Cedar St. Boardman Bld 3rd fl., New Haven, CT 06510, United States. Electronic address:

Background: CT angiography (CTA) can be performed pre-operatively for perforator mapping in autologous breast reconstruction. The full impact of incidental CTA findings on breast reconstruction remains unclear.

Methods: CTAs were reviewed for all patients who underwent imaging prior to autologous breast reconstruction at Yale New Haven Hospital from 2013-2018. Read More

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November 2018

Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy.

J Matern Fetal Neonatal Med 2018 Dec 2:1-7. Epub 2018 Dec 2.

a Department of Perinatology and Gynecology , Poznan University of Medical Sciences , Poznań , Poland.

Introduction: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis.

Objective: The aim of this study was to investigate the relationship between endocan serum levels and various types of hypertensive disorders in pregnant women.

Patients And Methods: We created three study groups (preeclampsia [n = 60], chronic hypertension [n = 39], gestational hypertension [n = 58]) and the control group consisting of 59 healthy pregnant women. Read More

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December 2018

Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients.

Clinics (Sao Paulo) 2018 Dec 3;73:e679. Epub 2018 Dec 3.

Department of gynecologic oncology, the First Affiliated Hospital of Bengbu Medical College, Anhui, China.

Objective: This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients.

Methods: Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Read More

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December 2018
1 Read

Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only 9 cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe 2 patients with ovarian Wilms tumor: a 36-yr-old female (patient 1) and a 16-yr-old female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. Read More

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December 2018
1 Read

A clinically structured and partnered approach to genetic testing in Trinidadian women with breast cancer and their families.

Breast Cancer Res Treat 2018 Dec 4. Epub 2018 Dec 4.

Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Introduction: Breast cancer (BC) is the leading cause of cancer death in Caribbean women. Across the Caribbean islands, the prevalence of hereditary breast cancer among unselected breast cancer patients ranges from 5 to 25%. Moreover, the prevalence of BC among younger women and the high mortality in the Caribbean region are notable. Read More

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December 2018

The impact of mammalian target of rapamycin inhibition on bone health in postmenopausal women with hormone receptor-positive advanced breast cancer receiving everolimus plus exemestane in the phase IIIb 4EVER trial.

J Bone Oncol 2019 Feb 2;14:010-10. Epub 2018 Oct 2.

Department of Oncology, Bethanien Hospital, Frankfurt am Main, Germany.

Background: Breast cancer and its treatments are associated with a detrimental effect on bone health. Here we report the results of an exploratory analysis assessing changes in levels of biomarkers of bone metabolism in patients enrolled in the phase IIIb 4EVER study.

Methods: The 4EVER trial investigated everolimus in combination with exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer. Read More

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February 2019

A call for the introduction of gender-neutral HPV vaccination to national immunisation programmes in Africa.

Lancet Glob Health 2018 Nov 30. Epub 2018 Nov 30.

Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA. Electronic address:

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November 2018

Provider Perceptions, Opinions, and Insights Into Uterine Transplantation in Canada.

J Obstet Gynaecol Can 2018 Dec 1. Epub 2018 Dec 1.

Department of Obstetrics and Gynecology, Faculty of Medicine, McGill University, Montréal, QC. Electronic address:

Objective: This study sought to evaluate perceptions and insights regarding uterine transplantation among members of a women's health care national specialty organization in Canada.

Methods: The investigators obtained permission and used an electronic survey developed by Bortoletto et al. to conduct a cross-sectional study of members of the SOGC between April and May 2018. Read More

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December 2018

Endometrial cancer: an overview of novelties in treatment and related imaging keypoints for local staging.

Cancer Imaging 2018 Dec 4;18(1):45. Epub 2018 Dec 4.

Department of Radiology, Istituto Europeo di Oncologia, via Ripamonti 435, 20141, Milan, Italy.

Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is needed for evaluation of local extent and detection of distant metastases in order to guide treatment planning. Read More

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December 2018

Smoking during pregnancy as a possible risk factor for pediatric neoplasms in the offspring: A population-based cohort study.

Addict Behav 2018 Nov 27;90:349-353. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: The aim of this study was to evaluate the association between maternal smoking during pregnancy and future risk of childhood neoplasm risk.

Study Design: A population based cohort analysis comparing the risk for long-term childhood neoplasms in children born (1991-2014) to mothers that smoked during pregnancy vs. those that did not. Read More

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November 2018
2 Reads

Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue.

Phys Med Biol 2018 Dec 4;63(23):235020. Epub 2018 Dec 4.

College of Optical Sciences, The University of Arizona, Tucson 85721, AZ, United States of America.

Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Optical coherence tomography (OCT) has been applied successfully to experimentally image the ovaries in vivo; however, a robust method for analysis is still required to provide quantitative diagnostic information. Recently, texture analysis has proved to be a useful tool for tissue characterization; unfortunately, existing work in the scope of OCT ovarian imaging is limited to only analyzing 2D sub-regions of the image data, discarding information encoded in the full image area, as well as in the depth dimension. Read More

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December 2018
1 Read

[Diffusion-weighted imaging texture features in differentiation of malignant from benign nonpalpable breast lesions for patients with microcalcifications-only in mammography].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):400-404

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Objective: To evaluate the application of MR diffusion-weighted imaging(DWI) texture features in differentiation of malignant from benign nonpalpable breast lesion for patients with microcalcifications-only in mammography.

Methods: The clinical and MR-DWI data of 61 patients with microcalcifications, who underwent three-dimensional positioning of breast X-ray wire from October 2012 to December 2015 in Zhejiang Cancer Hospital, were retrospectively analyzed, including 38 patients with malignant lesions and 23 patients with benign lesions. Two radiologists independently drew the regions of interest (ROI) on DWI for image segmentation, and 6 histogram features and 16 grayscale symbiosis matrix (GLCM) texture features were extracted on each ROI. Read More

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February 2018

Warburg effect in Gynecologic cancers.

J Obstet Gynaecol Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Mammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so-called "Warburg effect" in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment. Glucose is converted into lactate without going into mitochondria after being metabolized in glycolysis. Read More

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December 2018

Impact on Patient Care of a Multidisciplinary Center Specializing in Colorectal and Pelvic Reconstruction.

Front Surg 2018 19;5:68. Epub 2018 Nov 19.

Center for Colorectal and Pelvic Reconstruction (CCPR), Nationwide Children's Hospital, Columbus, OH, United States.

Many patients with an anorectal malformation (ARM) or pelvic anomaly have associated urologic or gynecologic problems. We hypothesized that our multidisciplinary center, which integrates pediatric colorectal, urologic, gynecologic and GI motility services, could impact a patient's anesthetic exposures and hospital visits. We tabulated during 2015 anesthetic/surgical events, endotracheal intubations, and clinic/hospital visits for all patients having a combined procedure. Read More

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November 2018

Undescended ovary and fallopian tube presenting as appendiceal mucocele.

Facts Views Vis Obgyn 2018 Mar;10(1):47-50

Sint-Jozef Kliniek, Department of gynecology and obstetrics, Kasteelstraat 23, 2880 Bornem, Belgium.

Undescended ovary is a rare congenital gynecologic condition, frequently associated with urogenital malformations including unicornuate uterus and ectopic kidneys or renal agenesis. Although ectopic ovaries are mostly found during an infertility work up, its role in infertility is still unknown. We report a 38-year-old patient presenting with pain in the right lower quadrant. Read More

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Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers.

Nat Med 2018 Dec 3. Epub 2018 Dec 3.

Division of Molecular Oncology & Immunology, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T cells at such tumor sites. However, these efforts only have value if the intratumoral T cell receptor (TCR) repertoire of such cells is intrinsically tumor reactive, and this has not been established in an unbiased manner for most human cancers. To address this issue, we analyzed the intrinsic tumor reactivity of the intratumoral TCR repertoire of CD8 T cells in ovarian and colorectal cancer-two tumor types for which T cell infiltrates form a positive prognostic marker. Read More

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December 2018
3 Reads

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.

Redox Biol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address:

Ovarian cancer remains the most lethal gynecologic malignancy, and is primarily diagnosed at late stage when considerable metastasis has occurred in the peritoneal cavity. At late stage abdominal cavity ascites accumulation provides a tumor-supporting medium in which cancer cells gain access to growth factors and cytokines that promote survival and metastasis. However, little is known about the redox status of ascites, or whether antioxidant enzymes are required to support ovarian cancer survival during transcoelomic metastasis in this medium. Read More

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November 2018
1 Read

Neoadjuvant chemotherapy in advanced ovarian cancer: optimal patient selection and response evaluation.

Chin Clin Oncol 2018 Dec;7(6):58

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy and is the seventh most common cancer among women worldwide. The primary debulking surgery (PDS) followed by adjuvant chemotherapy (ACT) is a standard treatment of advanced EOC. However, there are still several limitations, such as high recurrence rate and subsequent chemoresistance. Read More

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December 2018
6 Reads

A homozygous RNF220 mutation leads to male infertility with small-headed sperm.

Gene 2018 Nov 27. Epub 2018 Nov 27.

Human Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Morphological abnormality of spermatozoa head is a human infertility syndrome caused by spermatogenesis defects. The genetic alterations associated with macrozoospermia, globozoospermia and acephalic spermatozoa are relatively definite, whereas the underlying pathogenesis of small-headed sperm remains unclear. Here, we report a 32-year-old infertile male from a consanguineous family, who presented with 95% of small-headed sperm. Read More

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November 2018
3 Reads

Self-administered lidocaine gel for local anesthesia prior to osmotic dilator placement: a randomized trial.

Contraception 2018 Nov 27. Epub 2018 Nov 27.

Stanford University, Department of Obstetrics and Gynecology, Division of Family Planning Services and Research, 300 Pasteur Drive, HG 332, Palo Alto, CA, USA 94305. Electronic address:

Objective(s): To compare pain scores during cervical dilator placement prior to dilation and evacuation (D&E) with patient-administered vaginal lidocaine gel versus lidocaine paracervical block (PCB).

Study Design: We conducted an unblinded randomized trial of women≥18years of age undergoing surgical abortion at≥16weeks gestation in two outpatient clinics. We randomized participants to receive self-administered lidocaine gel 2% 20mL intravaginally 15-30min before procedure initiation, or lidocaine 1% 12mL PCB immediately prior to dilator placement. Read More

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November 2018

Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.

Arch Pathol Lab Med 2018 Dec;142(12):1485-1502

From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More

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December 2018
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Frontiers in Gynecologic Pathology.

Arch Pathol Lab Med 2018 Dec;142(12):1457-1458

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Hui); and the Department of Pathology, Princeton Medical Center, Plainsboro, New Jersey; the Department of Biological Sciences, Rutgers University, Newark, New Jersey; the Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, New Jersey; and Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey (Dr Zhang).

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December 2018
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