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J Eur Acad Dermatol Venereol 2022 Jun 24. Epub 2022 Jun 24.

Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden; Dermatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Background: The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are reassuring, but data specific to children are missing. Moreover, COVID-19 could impact the course of psoriasis in children. Read More

Ann Dermatol 2022 Jun 20;34(3):200-205. Epub 2022 May 20.

Department of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.

Background: The phenotypic heterogeneity of psoriasis is suspected to reflect differences in its pathogenesis, but not yet completely elucidated. Studies of the Th1 and Th17 cytokines associated with different phenotypes of psoriasis have yielded inconsistent results.

Objective: To investigate the tissue expression levels of Th1 and Th17 cytokines among patients with chronic plaque psoriasis, acute guttate psoriasis, and healthy control. Read More

Cutis 2022 Feb;109(2):101-102

Wellness Dermatology, Lawrenceville, New Jersey.

Guttate psoriasis is a subgroup of psoriasis that most commonly presents as raindroplike, erythematous, silvery, scaly papules. Guttate psoriatic flares may follow rhinovirus or COVID-19 infection due to dysregulation of the innate immune response. We describe the case of a patient who experienced a moderate psoriatic flare 3 weeks after diagnosis of SARS-CoV-2 infection. Read More

Dermatol Ther 2022 Jun 3:e15617. Epub 2022 Jun 3.

Dermatology Department, Fattouma Bourguiba Hospital, Dermo-Respiratory Research Laboratory UR14 SP 03, University of Medicine, Monastir, Tunisia.

JAAD Case Rep 2022 Jun 5;24:82-87. Epub 2022 May 5.

Department of Dermatology, Liverpool Hospital, Liverpool, Australia.

Microb Pathog 2022 Jun 30;167:105560. Epub 2022 Apr 30.

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China. Electronic address:

Background: Guttate psoriasis (GP) and psoriasis plaques (PP) are common subtypes of psoriasis. Previous studies have fully researched the association between psoriasis and gut microbiota. However, the differences in gut microbiota between GPs and PPs are still unknown. Read More

Niger Postgrad Med J 2022 Apr-Jun;29(2):155-160

Department of Internal Medicine, Barau Dikko Teaching Hospital, Kaduna State University, Kaduna, Nigeria.

Background: Psoriasis is a chronic inflammatory skin disease which may be associated with joint, cardiovascular, metabolic or psychiatric disease. Countries in North America, Northern Europe and Australia have the highest burden of disease while those in Asia, South America and Africa, the lowest. We report our experience of psoriasis in Kaduna, Nigeria, over 20 years and compare this with previous reports in the same area and in other parts of Nigeria and Africa. Read More

Clin Cosmet Investig Dermatol 2022 28;15:347-355. Epub 2022 Feb 28.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Psoriasis is an inflammatory immune-mediated illness with an unknown cause. It is a painful, disfiguring, and disabling condition without a complete cure and has enormous negative effects on patients' quality of life. Ethnicity, genetics, and environmental variables all have a role in determining the disease's prevalence. Read More

An Bras Dermatol 2022 Mar-Apr;97(2):271-273. Epub 2021 Dec 30.

Dermatology and Venereology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal; Dermatology and Venereology University Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Dermatology Research Unit, iMM João Lobo Antunes, University of Lisbon, Lisbon, Portugal.

J Healthc Eng 2022 15;2022:7541583. Epub 2022 Jan 15.

Department of Biomedical Engineering, Ziauddin University, Faculty of Engineering, Science, Technology and Management (ZUFESTM), Karachi, Pakistan.

Psoriasis is a chronic inflammatory skin disorder mediated by the immune response that affects a large number of people. According to latest worldwide statistics, 125 million individuals are suffering from psoriasis. Deep learning techniques have demonstrated success in the prediction of skin diseases and can also lead to the classification of different types of psoriasis. Read More

Dermatol Pract Concept 2021 Oct 1;11(4):e2021100. Epub 2021 Oct 1.

Department of Dermatology University of Rome "Tor Vergata", Rome, Italy.

Front Med (Lausanne) 2021 23;8:812010. Epub 2021 Dec 23.

Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan.

The temporal association had been reported between vaccination and exacerbation of psoriasis, and episodes of psoriasis flare-up have recently been attributed to COVID-19 vaccines. We recruited 32 unimmunized controls and 51 vaccinated psoriasis patients, 49 of whom were under biological therapy, with regular clinic visits receiving a total of 63 shots of vaccines, including 30 doses of Moderna mRNA-1273 and 33 doses of AstraZeneca-Oxford AZD1222. Fifteen episodes of exacerbation attacked within 9. Read More

Dermatol Ther 2022 04 12;35(4):e15309. Epub 2022 Jan 12.

Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.

Clin Dermatol 2021 Nov-Dec;39(6):966-984. Epub 2021 Jul 25.

Discovery Life Sciences, Powell, Ohio; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

A total of 22 patients who had developed an adverse cutaneous reaction to the Moderna or Pfizer vaccine underwent biopsies. Each patient was assessed light microscopically, and, in select biopsies, spike glycoprotein and cytokine assessment were also conducted. The patients developed self-limited cutaneous reactions often described clinically as urticarial or eczematous within 1 day to 4 weeks after receiving the first or second dose of the Pfizer or Moderna vaccine. Read More

Exp Dermatol 2022 05 13;31(5):753-763. Epub 2021 Dec 13.

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

TNFα-inhibitor-induced psoriasis is mediated by the type-I interferon pathway, of which IFNα, LL37 and IL-36γ are major players. A subset of patients treated with TNFα inhibitors develop small plaque psoriatic lesions. Small plaque psoriasis is similarly observed in patients on immune checkpoint inhibitors (ICI), and with concurrent systemic lupus erythematosus (SLE) or positive antinuclear antibody (ANA). Read More

J Cutan Pathol 2022 May 27;49(5):463-467. Epub 2021 Dec 27.

Mycology Research Laboratory and UOA/HCPF Culture Collection, Microbiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Psoriasis is currently regarded a mixed autoimmune and autoinflammatory disease. This report describes for the first time the detection of a saprophytic, human oral Tenericutes species, Mycoplasma faucium, in the skin lesions of a patient presenting initially guttate and later plaque psoriasis. An unusual finding in standard histopathology investigation consisted of round and oval thinly stained or unstained, possibly intracellular structures, apparently directly pressing on keratinocyte nuclei of the psoriatic stratum spinosum. Read More

J Eur Acad Dermatol Venereol 2022 Mar 29;36(3):472-479. Epub 2021 Dec 29.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Background: Germline autosomal dominant and autosomal recessive mutations in PERP, encoding p53 effector related to PMP-22 (PERP), a component of epidermal desmosomes, have been associated with a spectrum of keratodermas. Monoallelic nonsense mutations cause Olmsted syndrome with severe periorificial keratoderma and palmoplantar keratoderma (PPK). Biallelic recessive frameshift and missense mutations are associated with milder forms of the disease, including generalised erythrokeratoderma and PPK. Read More

Front Med (Lausanne) 2021 29;8:731911. Epub 2021 Oct 29.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Parc Científic de Barcelona, Barcelona, Spain.

Psoriasis is a common inflammatory skin condition resulting from the interplay between epidermal keratinocytes and immunological cellular components. This sustained inflammation is essentially driven by pro-inflammatory cytokines with the IL-23/IL-17 axis playing a critical central role, as proved by the clinical efficacy of their blockade in patients. Among all the CD45R0 memory T cell subsets, those with special tropism for cutaneous tissues are identified by the expression of the Cutaneous Lymphocyte-associated Antigen (CLA) carbohydrate on their surface, that is induced during T cell maturation particularly in the skin-draining lymph nodes. Read More

J Clin Med 2021 Nov 7;10(21). Epub 2021 Nov 7.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020. Read More

J Dermatol 2022 Jan 28;49(1):e30-e31. Epub 2021 Oct 28.

Department of Dermatology, Seoul National University Hospital, Seoul, Korea.

Case Rep Dermatol Med 2021 11;2021:9448636. Epub 2021 Sep 11.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Induction of new psoriasis sites was reported in only a small amount of psoriasis patients undergoing tattooing, despite the intuitive belief that tattoo trauma might awaken the disease due to the isomorphic phenomenon of Koebner. In this case report, we discuss a patient who presented with a remarkable sparing of his three tattoo sites during a guttate psoriasis flare-up that was unrelated to tattooing. The spatial concordance of tattoo and psoriasis lesions was analyzed on clinical pictures of tattoo sites taken during the psoriasis episode. Read More

J Cosmet Dermatol 2021 Oct 20;20(10):3064-3065. Epub 2021 Aug 20.

Department of Dermatology, IMS & SUM Hospital, Bhubaneswar, India.

Clin Case Rep 2021 Jul 28;9(7):e04542. Epub 2021 Jul 28.

Department of Dermatology The Military Hospital of Tunis Tunis Tunisia.

SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is associated with flares of psoriasis in patients with well-documented disease. Both viral infection and medications used for treatment, like hydroxychloroquine, were incriminated. Herein, we report the case of a 25-year-old male patient who presented a first-onset guttate psoriasis following a COVID-19 infection. Read More

J Cutan Pathol 2022 Feb 23;49(2):116-122. Epub 2021 Aug 23.

Department of Dermatology, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.

Background: Expression of microRNA-21 (miR-21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP-3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFα) sheddase TACE (TNFα-converting enzyme)/ADAM17. We described the profile of miR-21 and TIMP-3 in paradoxical psoriasiform reactions induced by anti-TNFα drugs and in a control group to elucidate the pathogenesis of this reactions.

Methods: We performed an analytic, cross-sectional, prospective, experimental case-control study. Read More

J Eur Acad Dermatol Venereol 2021 Nov 4;35(11):e752-e755. Epub 2021 Aug 4.

Department of Dermatology, Inselspital - Bern University Hospital, University of Bern, Bern, Switzerland.

Clin Case Rep 2021 Jul 16;9(7):e04568. Epub 2021 Jul 16.

Internal Medicine Department Hamad Medical Corporation Doha Qatar.

Guttate psoriasis is a rare dermatological presentation of SARS-CoV-2 infection and is seen mainly in patients with an underlying disease psoriasis. Read More

Life (Basel) 2021 Jun 27;11(7). Epub 2021 Jun 27.

Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszów, Poland.

Psoriasis is a chronic, inflammatory skin disease present in about 3% of the world's population. The clinical symptoms manifest diversely, therefore one can distinguish several subtypes of psoriasis. The majority of patients with psoriasis experience pruritus, which is an unpleasant sensation that decreases patients' quality of life. Read More

Clin Med (Lond) 2021 05;21(3):170-173

St John's Institute of Dermatology, London, UK

Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population affected in the UK. Read More

Med Lav 2021 Apr 20;112(2):168-170. Epub 2021 Apr 20.

Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit - Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

Introduction: Chemical burns are a risk in domestic and occupational accidents due to the common use of caustic agents. Long-term sequelae are normally due to the amount of skin and underlying tissues damaged. We describe a case of work-related chemical burns with unusual evolution in guttate psoriasis. Read More

JAMA Dermatol 2021 Apr 14. Epub 2021 Apr 14.

Division of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Importance: Psoriasis is a heterogeneous disease. Improved understanding of prognosis and long-term outcomes in new-onset psoriasis may improve care.

Objective: To describe the clinical course of psoriasis and identify possible indicators of long-term outcomes. Read More