338 results match your criteria Guttate Psoriasis


Identifying a Core Domain Set to Assess Psoriasis in Clinical Trials.

JAMA Dermatol 2018 Jun 6. Epub 2018 Jun 6.

Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles.

Importance: There is no consensus on which domains should be measured or which instruments should be used in clinical trials for psoriasis therapies.

Objective: To achieve international consensus among psoriasis stakeholders on a core set of domains that should be measured in all psoriasis clinical trials.

Design, Setting, And Participants: Literature review, pre-Delphi survey exercises, nominal group discussions, and audience voting at 4 stakeholder meetings were used to develop candidate domains for 2 rounds of a Delphi survey. Read More

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June 2018
1 Read

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007-2016).

Dermatol Res Pract 2018 23;2018:4371471. Epub 2018 Apr 23.

Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population.

Aim: To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia.

Materials And Methods: Data were obtained from the Malaysian Psoriasis Registry (MPR). Read More

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Association of the novel susceptible locus rs9266150 with clinical features of psoriasis vulgaris in the Chinese Han population.

Exp Dermatol 2018 Apr 6. Epub 2018 Apr 6.

Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, 230032, China.

Background: Psoriasis is a chronic multifactorial disease, and is considered to be strongly associated with the major histocompatibility complex (MHC) region. We have discovered an independent, novel and susceptible psoriasis risk HLA loci, rs9266150; P = 4.52 × 10 ) for the first time. Read More

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April 2018
4 Reads

Complete resolution of guttate psoriasis after tonsillectomy.

Ear Nose Throat J 2018 Mar;97(3):62-63

Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

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Anti-Programmed Cell Death-1-Induced Plaque and Guttate Psoriasis.

Indian J Dermatol 2018 Jan-Feb;63(1):88-89

Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. E-mail:

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March 2018
4 Reads

Is there a correlation of serum and tissue T helper-1 and -2 cytokine profiles with psoriasis activity and severity? A cross-sectional study.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):414-418

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Background: Previous studies correlating Th1 and Th2 cytokine profiles with psoriasis activity provided inconsistent results. Correlation of tissue cytokine levels with psoriasis severity has not been studied till now.

Objective: To compare serum and tissue Th1 and Th2 cytokine profiles of patients with active and stable psoriasis as well as healthy controls, and to correlate them with psoriasis severity. Read More

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March 2018
2 Reads

Treatment of selective antibody deficiency with IVIG resulting in decreased frequency of streptococcal infection and improvement of guttate psoriasis.

Dermatol Online J 2017 08 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Saint Louis University, Saint Louis, Missouri.

The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

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Unique urticarial presentation of minocycline-induced lupus erythematosus.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, University of California, Davis, Sacramento, CA USA, Department of Biological Sciences, California State Univeristy, Sacramento, CA USA.

The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

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A secondary syphilis rash with scaly target lesions.

Oxf Med Case Reports 2018 Feb 1;2018(2):omx089. Epub 2018 Feb 1.

Microbiologie Médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.

A 40-year-old man reported a 5-day history of fever and malaise, followed by a pruritic generalized rash. He had well-demarcated erythematous papules and plaques with scaling. The patient was diagnosed with secondary syphilis. Read More

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February 2018

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

An Bras Dermatol 2017 Nov-Dec;92(6):826-829

Department of Dermatology, Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. Read More

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April 2018
7 Reads

Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese Society for Psoriasis Research.

J Dermatol 2018 Mar 8;45(3):293-301. Epub 2017 Nov 8.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

Since 1982, the Japanese Society for Psoriasis Research has conducted annual epidemiological surveys of patients with psoriasis. Kawada et al. have reported data for 1982-2001 and Takahashi et al. Read More

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March 2018
4 Reads

Anti-PD1/PDL1 induced psoriasis.

Curr Probl Cancer 2017 Nov - Dec;41(6):407-412. Epub 2017 Oct 18.

Dermato Oncology Department, Cutaneous Toxicities Clinic, Andreas Sygros Hospital, University of Athens, Athens, Greece.

Background: Immune checkpoint inhibitors are novel agents approved for the treatment of late-stage malignancies. Despite its important clinical benefits, checkpoint inhibition is associated with a unique spectrum of side effects known as immune-related adverse events. Skin toxicities are the most frequent immune-related adverse events during anti-PD1 blockade therapies. Read More

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October 2017
2 Reads

HLA-Cw6 and psoriasis.

Authors:
L Chen T-F Tsai

Br J Dermatol 2018 Apr 2;178(4):854-862. Epub 2018 Mar 2.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan.

Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities and treatment outcomes. Read More

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April 2018
1 Read

Microbe-Dependent Induction of IL-9 by CLA T Cells in Psoriasis and Relationship with IL-17A.

J Invest Dermatol 2018 Mar 17;138(3):580-587. Epub 2017 Oct 17.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Spain. Electronic address:

IL-9 is present in psoriatic lesions and is produced by lymphocytes. However, it is not known whether this cytokine is induced by relevant pathogenic triggers of psoriasis, such as Streptococcus pyogenes. Here we addressed the production of IL-9 in response to various pathogens in a psoriatic ex vivo model. Read More

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March 2018
3 Reads

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan.

J Dermatol 2018 Mar 19;45(3):314-317. Epub 2017 Oct 19.

Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28. Read More

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March 2018
3 Reads

Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies.

J Leukoc Biol 2018 Feb 29;103(2):193-213. Epub 2017 Dec 29.

School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.

Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. Read More

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February 2018
8 Reads

Ustekinumab-induced remission of recalcitrant guttate psoriasis: A case series.

JAAD Case Rep 2017 Sep 1;3(5):432-435. Epub 2017 Sep 1.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

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September 2017
3 Reads

Paradoxical Side Effect Related With Anti-Tumor Necrosis Factor Alpha Treatment.

Med Arch 2017 Apr;71(2):148-150

Katip Celebi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Izmir, Turkey.

Introduction: Anti-tumor necrosis factor (anti-TNF) treatments are effective in controlling disease activity in many immune-mediated diseases such as psoriasis and ankylosing spondylitis (AS). Although side effects such as infection and skin reactions are predictable in anti-TNF treatment; susceptibility to psoriasis is considered as a paradoxical side effect.

Case Report: We report a case of forty-year-old male patient with 7 years of AS was taking anti-TNF therapy. Read More

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April 2017
3 Reads

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE).

Ann Dermatol 2017 Aug 21;29(4):462-470. Epub 2017 Jun 21.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date.

Objective: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. Read More

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August 2017
19 Reads

Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients.

Ann Dermatol 2017 Aug 21;29(4):422-426. Epub 2017 Jun 21.

Department of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.

Background: Although phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines.

Objective: To investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy controls, and 2) between patients with different psoriasis phenotypes.

Methods: Twenty-five patients with psoriasis (10 with guttate psoriasis and 15 with plaque psoriasis) and 5 healthy volunteers were enrolled in this study. Read More

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August 2017
5 Reads

Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.

Clin Rev Allergy Immunol 2017 Dec;53(3):371-393

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud's phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet's syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. Read More

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December 2017
16 Reads

Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population.

J Gene Med 2017 Sep 19;19(9-10). Epub 2017 Sep 19.

Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Background: The human major histocompatibility complex (MHC) is known to be highly polymorphic and has been identified to be associated with numerous diseases. The HLA-DPB1 and BTNL2 genes were associated with psoriasis for the first time. The present study aims to investigate the relevance of the HLA-DPB1 and BTNL2 genes with respect to clinical phenotypes of psoriasis vulgaris (PV). Read More

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September 2017
8 Reads
2.47 Impact Factor

Guttate psoriasis triggered by perianal streptococcal infection.

Clin Exp Dermatol 2017 Jul 22;42(5):536-538. Epub 2017 May 22.

Department of Dermatology, University Medical Center Utrecht, Wilhelmina Children's Hospital, the Netherlands.

The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Read More

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July 2017
1 Read

Certolizumab-induced guttate psoriasiform dermatitis.

Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.

Division of Dermatology, University of Kansas Medical Center, Kansas City.

Certolizumab is a TNF inhibitor that has showngreat efficacy in chronic inflammatory diseases. Wereport a patient exhibiting a novel adverse effect ofcertolizumab: drug-induced guttate psoriasiformeruption. A review of the mechanism of psoriasiformdrug eruptions is also included. Read More

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January 2017
2 Reads

Childhood psoriasis.

Authors:
Emmanuel Mahé

Eur J Dermatol 2016 Dec;26(6):537-548

Department of Dermatology, Hôpital Victor Dupouy, 69 rue du Lieutenant-Colonel Prud'hon, 95100 Argenteuil, France.

Psoriasis is a common chronic inflammatory skin disease. Recently, few data have been published on epidemiology, comorbidity, or therapy in children with psoriasis. Psoriasis affects up to 2% of children in Europe, even during the first months of life. Read More

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December 2016
7 Reads

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment.

Dermatology 2016 25;232(5):626-632. Epub 2016 Nov 25.

Department of Dermatology, Hospital Universitario Sanitas La Zarzuela, Madrid, Spain.

Background: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB).

Objective: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis.

Material And Methods: We carried out a prospective, open, and observational study. Read More

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July 2017
2 Reads

Prevalence of psoriatic arthritis and its correlates among patients with psoriasis in Greece: results from a large retrospective study.

J Eur Acad Dermatol Venereol 2016 Oct 10;30(10):1749-1752. Epub 2016 Aug 10.

2nd Department of Dermatology and Venereology, University of Athens, Attikon General Hospital, Chaidari, Greece.

Objectives: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital.

Methods: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013.

Results: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Read More

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October 2016
1 Read

Childhood psoriasis: a survey among pediatricians in Italy.

G Ital Dermatol Venereol 2018 Aug 5;153(4):473-476. Epub 2016 Oct 5.

Dermatology and Skin Cancer Unit, Santa Maria Nuova Hospital and Institute for Research and Care, Reggio Emilia, Italy -

Background: Psoriasis is one of the most common inflammatory skin diseases. There seem to be an increasing interest in childhood psoriasis in recent years.

Methods: We conducted a survey among pediatricians in Italy. Read More

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August 2018
2 Reads

Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature.

Acta Dermatovenerol Croat 2016 Aug;24(3):169-74

Prof. Massimo De Martinis, MD, Department of Life, Health AND Environmental Sciences, University of L'Aquila, L'Aquila, Italy;

Tumor necrosis factor alpha (TNF-α) inhibitors revolutionized the management of patients affected by autoimmune diseases such as inflammatory bowel diseases, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and psoriasis. The biologic agents targeted to block TNF-α such as infliximab, adalimumab, certulizumab pegol, etanercept, and golimumab, have a good safety profile; however, with increasing, broader, and prolonged use, patients could be exposed to an increased risk of adverse reactions including a wide spectrum of dermatological conditions of different etiology and morphology. Among these, of particular interest is the development of skin immune-mediated diseases that seem to be the consequence of the paradoxical inflammation induced by anti-TNF-α therapy. Read More

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August 2016
2 Reads

Dermoscopy in General Dermatology: A Practical Overview.

Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

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December 2016
25 Reads

Juvenile psoriasis: an epidemiological study of 69 cases.

G Ital Dermatol Venereol 2018 Aug 30;153(4):469-472. Epub 2016 Jun 30.

Department of Medical Sciences, University Clinic of Dermatology, University of Turin, Turin, Italy -

Background: Psoriasis is a common inflammatory skin disease that affects people of every age; prevalence in pediatric population is unknown because of the lack of studies.

Methods: We collected data about patients 0-18 years old coming to our center in the period from November 2010 to September 2012.

Results: We found 69 children (38 males, 31 females) affected by psoriasis, with a male-to-female ratio of 1. Read More

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August 2018
4 Reads

Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.

Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.

Temple University School of Medicine, Philadelphia, PA, USA.

Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

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October 2016
7 Reads

Streptococcus pyogenes-induced cutaneous lymphocyte antigen-positive T cell-dependent epidermal cell activation triggers TH17 responses in patients with guttate psoriasis.

J Allergy Clin Immunol 2016 Aug 4;138(2):491-499.e6. Epub 2016 Apr 4.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Background: Guttate psoriasis (GP) is characterized by acute onset of small, rounded psoriatic lesions. Although this particular phenotype of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA-Cw6(+) patients, the specific immunologic response to this innate stimulus that causes these skin lesions is poorly understood.

Objective: This study aims to elucidate how key cellular elements of patients with GP respond to Streptococcus pyogenes and whether this initial immune response is favored by the genetic and environmental background of these patients. Read More

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August 2016
16 Reads

Pediatric psoriasis treated with apremilast.

Authors:
Rebecca L Smith

JAAD Case Rep 2016 Jan 27;2(1):89-91. Epub 2016 Feb 27.

Fort Mill Dermatology, LLC, Fort Mill, South Carolina.

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January 2016
2 Reads

Tailor systemic therapy to the patient with severe psoriasis.

Practitioner 2016 Feb;260(1790):23-6, 3

There is no standard definition regarding the severity of psoriasis, and a number of factors should be considered, including the extent and stability of skin disease, involvement of joints, response to treatment, and impact on quality of life. Erythrodermic psoriasis and pustular psoriasis are severe conditions and the patient may be systemically unwell and febrile. NICE recommends that four key areas should be evaluated and recorded when assessing patients: severity, using the static Physician's Global Assessment (sPGA); disease impact on physical, psychological and social wellbeing using the Dermatology Life Quality Index (DLQI); the presence of psoriatic arthritis; and comorbidities. Read More

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February 2016
2 Reads

Anti-Tumor Necrosis Factor α-Related Psoriatic Lesions in Children with Inflammatory Bowel Disease: Case Report and Systematic Literature Review.

Pediatr Dermatol 2016 Mar-Apr;33(2):e174-8

Department of Dermatology, School of Medical Sciences, Universidade de São Paulo, São Paulo, Brazil.

We report a child with Crohn's disease and infliximab-induced guttate psoriasis. We also performed a systematic literature review on this intriguing paradoxical phenomenon in children with inflammatory bowel disease. Read More

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January 2017
2 Reads
1.52 Impact Factor

Guttate psoriasis outcomes.

Cutis 2016 Feb;97(2):140-4

Geisinger Medical Center, Danville, Pennsylvania, USA.

Guttate psoriasis (GP) typically occurs following an acute infection such as streptococcal pharyngitis. It is thought to have a better prognosis than chronic plaque psoriasis (PP). This retrospective cohort study of 79 patients with GP aims to assess the likelihood of developing PP after the first episode of GP as well as compare clinical and laboratory data in patients with GP who do and do not develop PP. Read More

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February 2016
1 Read

Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland.

Postepy Dermatol Alergol 2015 Dec 11;32(6):455-8. Epub 2015 Dec 11.

Department of Dermatology, Venereology and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland Head of the Department: Prof. Waldemar Placek MD, PhD.

Introduction: The association of guttate psoriasis with a streptococcal throat infection and HLA-Cw*06 allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population.

Aim: To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA-Cw*06 allele in 70 patients with guttate psoriasis originating from northern Poland. Read More

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December 2015
4 Reads

Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis Patients: A Comparison between Plaque and Guttate Psoriasis.

Ann Dermatol 2015 Dec 7;27(6):738-43. Epub 2015 Dec 7.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University, Seoul, Korea.

Background: The phenotypic heterogeneity of psoriasis could be explained by the alternate activation of either T-helper (Th)-1- or Th-17-related cytokines. However, evidence directly supporting this hypothesis is scarce.

Objective: To characterize the expression of Th-1- and Th-17-related cytokines according to the morphological psoriasis phenotype: guttate vs. Read More

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December 2015
3 Reads

Psoriasis Targeted Therapy: Characterization of Interleukin 17A Expression in Subtypes of Psoriasis.

J Drugs Dermatol 2015 Oct;14(10):1133-6

Introduction: Psoriasis is a chronic, inflammatory autoimmune disease that affects about 3% of the general population in the United States with 17% suffering from moderate to severe psoriasis. The disease process is believed to be mediated by tumor necrosis factor (TNF)-α and cytokines secreted by specialized T-cell populations including Interleukin (IL)-17, IL-22, and Interferon (IFN) γ. IL-17 plays an important role in psoriasis. Read More

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October 2015
2 Reads

Possible Triggering Effect of Influenza Vaccination on Psoriasis.

J Immunol Res 2015 25;2015:258430. Epub 2015 Aug 25.

Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.

Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease and it can be provoked or exacerbated by a variety of different environmental factors, particularly infections and drugs. In addition, a possible association between vaccination and the new onset and/or exacerbation of psoriasis has been reported by a number of different authors. The aim of this study is to investigate the effects of influenza vaccination on patients with psoriasis. Read More

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May 2016
5 Reads

Antimicrobial peptide LL-37 along with peptidoglycan drive monocyte polarization toward CD14(high)CD16(+) subset and may play a crucial role in the pathogenesis of psoriasis guttata.

Am J Transl Res 2015 15;7(6):1081-94. Epub 2015 Jun 15.

Department of Laboratory Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine Nanjing 210014, Jiangsu Province, P. R. China.

The human cathelicidin LL-37 peptide is overexpressed in psoriasis and has been demonstrated to be a multifunctional modulator of innate immune response elements, including monocytes. Monocytes, categorized into three populations based on the cell surface expression of CD14 and CD16, are activated in psoriasis guttate and are commonly triggered by streptococcal infections. Peptidoglycan (PGN) is a major cell-wall component of streptococcus, and an increasing number of PGN-containing cells have been detected in psoriasis. Read More

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August 2015
2 Reads

Clinical profile, morbidity and outcome of adult patients with psoriasis at a district hospital in Northern Malaysia.

Med J Malaysia 2015 Jun;70(3):177-81

Sultan Abdul Halim Hospital, Department of Dermatology, Jalan Lencongan Timur, Bandar Amanjaya, Amanjaya, Sungai Petani 08000, Malaysia.

Introduction: Psoriasis is a common, chronic, relapsing, immune-mediated inflammatory disease. Our objective is to review the clinical profile, co-morbidities, and outcome of patients with psoriasis.

Methods: This is a cross-sectional study of outpatient psoriasis patients attending the dermatology clinic, Hospital Sultan Abdul Halim (HSAH) between January 2012 and June 2014. Read More

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June 2015
2 Reads

Recognizing Guttate Psoriasis and Initiating Appropriate Treatment.

W V Med J 2015 Jul-Aug;111(4):26-8

Guttate psoriasis is a less common form of psoriasis. It manifests with numerous small, teardrop shaped, scaly plaques on the trunk and extremities. The etiology includes both environmental and genetic factors. Read More

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Paradoxical psoriasiform reactions to anti-TNFα drugs are associated with genetic polymorphisms in patients with psoriasis.

Pharmacogenomics J 2016 08 21;16(4):336-40. Epub 2015 Jul 21.

Dermatology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain.

Paradoxical psoriasiform reactions to anti-tumor necrosis factor α (TNFα) agents have been described. We aimed to study the association between these reactions and polymorphisms in genes previously associated with psoriasis or other autoimmune diseases. A total of 161 patients with plaque-type psoriasis treated with anti-TNFα drugs were genotyped for 173 single-nucleotide polymorphisms (SNPs) using the Illumina Veracode genotyping platform. Read More

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August 2016
2 Reads

The practical usefulness of dermoscopy in general dermatology.

G Ital Dermatol Venereol 2015 Oct 18;150(5):533-46. Epub 2015 Jun 18.

Department of Experimental and Clinical Medicine Institute of Dermatology University of Udine, Udine, Italy -

Beside to traditional use, dermoscopy is more and more used in the assessment of other "general" dermatologic conditions, namely scalp and hair disorders (trichoscopy), nails abnormalities (onychoscopy), skin infections and infestations (entomodermoscopy), and cutaneous inflammatory diseases (inflammoscopy). Among the list of new applications of dermoscopy, the study of inflammatory dermatoses is probably the most promising topic in terms of development and usefulness, considering the large number of such disorders and the frequent problems in their differential diagnosis which the dermatologist encounters in own daily clinical practice. In this paper, we report selected relatively common clinical differential diagnosis issues concerning inflammatory dermatoses (and some clinically related noninflammatory conditions), analysing them by a dermoscopic point of view in order to assist their noninvasive resolution according to the available literature data and our personal experience, including papulosquamous dermatoses (guttate psoriasis, pityriasis lichenoides chronica, pityriasis rosea, lichen planus, lymphomatoid papulosis, classic pityriasis rubra pilaris, papulosquamous sarcoidosis, disseminated forms of porokeratosis and papulosquamous chronic GVHD), dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides, subacute cutaneous lupus erythematosus), palmar psoriasis vs. Read More

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October 2015
13 Reads

Guttate Psoriasis Following Streptococcal Vulvovaginitis in a Five-year-old Girl.

J Pediatr Adolesc Gynecol 2015 Oct 23;28(5):e127-9. Epub 2014 Oct 23.

The Dermatology Group, PA, Longwood, Florida.

Background: Guttate psoriasis is frequently associated with a preceding pharyngeal or perianal streptococcal infection in children. Despite Group A beta-hemolytic streptococci (GABHS) being the most common cause of specific bacterial vulvovaginitis in prepubertal girls, there are no reports of streptococcal vulvovaginitis triggering guttate psoriasis.

Case: A five-year-old girl presented with guttate psoriasis following an episode of Streptococcal pyogenes vulvovaginitis. Read More

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October 2015
2 Reads

Clinical profile of childhood-onset psoriasis and prevalence of HLA-Cw6: a hospital-based study from India.

Postgrad Med J 2015 Jun 6;91(1076):309-14. Epub 2015 May 6.

Department of Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Background: Childhood-onset psoriasis (COP), a distinct clinical entity, may be associated with HLA-Cw6 positivity and metabolic and cardiovascular complications. There is some evidence that HLA-Cw6 positivity is associated with more extensive or severe disease and that positivity is lower in Asian patients than in Caucasians. We describe the clinical profile, prevalence of the HLA-Cw6 allele, metabolic syndrome (MetS) and vitamin D deficiency in Indian patients with COP. Read More

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June 2015
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Nanotechnological approaches for the effective management of psoriasis.

Artif Cells Nanomed Biotechnol 2016 Sep 28;44(6):1374-82. Epub 2015 Apr 28.

a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.

Psoriasis is a chronic disorder with erythematous scaly patches, which typically affects the exposed surfaces of the body and scalp. Various factors such as bacterial infection, genetic and environmental factors, and immune disorders play an important role in causing psoriasis. Different types of psoriasis can be observed, such as guttate psoriasis, inverse psoriasis, pustular psoriasis, and psoriatic arthritis. Read More

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September 2016
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