J Gene Med 2017 Jun 5. Epub 2017 Jun 5.

Institute of Dermatology and Department of Dermatol ogy the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Background: The human major histocompatibility complex (MHC) is well known to be highly polymorphic and has been identified to be associated with numerous diseases. HLA-DPB1 gene and BTNL2 gene were associated with psoriasis for the first time. This study aims to investigate the relevance of HLA-DPB1 gene and BTNL2 gene with clinical phenotypes of psoriasis vulgaris (PV). Read More

Clin Exp Dermatol 2017 Jul 22;42(5):536-538. Epub 2017 May 22.

Department of Dermatology, University Medical Center Utrecht, Wilhelmina Children's Hospital, the Netherlands.

The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Read More

Eur J Dermatol 2016 Dec;26(6):537-548

Department of Dermatology, Hôpital Victor Dupouy, 69 rue du Lieutenant-Colonel Prud'hon, 95100 Argenteuil, France.

Psoriasis is a common chronic inflammatory skin disease. Recently, few data have been published on epidemiology, comorbidity, or therapy in children with psoriasis. Psoriasis affects up to 2% of children in Europe, even during the first months of life. Read More

Dermatology 2016 25;232(5):626-632. Epub 2016 Nov 25.

Department of Dermatology, Hospital Universitario Sanitas La Zarzuela, Madrid, Spain.

Background: Acute guttate psoriasis (AGP) is a distinctive clinical entity with good response to treatment with narrow-band ultraviolet B (NB-UVB).

Objective: To investigate the results of NB-UVB phototherapy in adult patients with adult guttate psoriasis.

Material And Methods: We carried out a prospective, open, and observational study. Read More

J Eur Acad Dermatol Venereol 2016 Oct 10;30(10):1749-1752. Epub 2016 Aug 10.

2nd Department of Dermatology and Venereology, University of Athens, Attikon General Hospital, Chaidari, Greece.

Objectives: To evaluate the prevalence and its clinical characteristics of psoriatic arthritis (PsA) in a specialized psoriasis clinic of a University Hospital.

Methods: In this retrospective study, 278 patients with psoriasis were evaluated between 2011 and 2013.

Results: The study included 278 patients with psoriasis: 144 (52%) were male and 134 (48%) female. Read More

G Ital Dermatol Venereol 2016 Oct 5. Epub 2016 Oct 5.

Pediatric Unit, ASL Napoli 1, Naples, Italy -

Background: Psoriasis is one of the most common inflammatory skin diseases. There seem to be an increasing interest in childhood psoriasis in recent years.

Methods: We conducted a survey among pediatricians in Italy. Read More

Acta Dermatovenerol Croat 2016 Aug;24(3):169-74

Prof. Massimo De Martinis, MD, Department of Life, Health AND Environmental Sciences, University of L'Aquila, L'Aquila, Italy;

Tumor necrosis factor alpha (TNF-α) inhibitors revolutionized the management of patients affected by autoimmune diseases such as inflammatory bowel diseases, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and psoriasis. The biologic agents targeted to block TNF-α such as infliximab, adalimumab, certulizumab pegol, etanercept, and golimumab, have a good safety profile; however, with increasing, broader, and prolonged use, patients could be exposed to an increased risk of adverse reactions including a wide spectrum of dermatological conditions of different etiology and morphology. Among these, of particular interest is the development of skin immune-mediated diseases that seem to be the consequence of the paradoxical inflammation induced by anti-TNF-α therapy. Read More

Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

G Ital Dermatol Venereol 2016 Jun 30. Epub 2016 Jun 30.

Clinica Dermatologica Università di Torino, Dipartimento di Scienze Mediche, Torino, Italia -

Background: Psoriasis is a common inflammatory skin disease that affects people of every age; prevalence in pediatric population is unknown because of the lack of studies.

Methods: We collected data about patients 0-18 years old coming to our centre in the period from November 2010 to September 2012.

Results: We found 69 children (38 males, 31 females) affected by psoriasis, with a M/F ratio of 1,2 and a prevalence of 0. Read More

Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.

Temple University School of Medicine, Philadelphia, PA, USA.

Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

J Allergy Clin Immunol 2016 Aug 4;138(2):491-499.e6. Epub 2016 Apr 4.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Background: Guttate psoriasis (GP) is characterized by acute onset of small, rounded psoriatic lesions. Although this particular phenotype of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA-Cw6(+) patients, the specific immunologic response to this innate stimulus that causes these skin lesions is poorly understood.

Objective: This study aims to elucidate how key cellular elements of patients with GP respond to Streptococcus pyogenes and whether this initial immune response is favored by the genetic and environmental background of these patients. Read More

JAAD Case Rep 2016 Jan 27;2(1):89-91. Epub 2016 Feb 27.

Fort Mill Dermatology, LLC, Fort Mill, South Carolina.

Practitioner 2016 Feb;260(1790):23-6, 3

There is no standard definition regarding the severity of psoriasis, and a number of factors should be considered, including the extent and stability of skin disease, involvement of joints, response to treatment, and impact on quality of life. Erythrodermic psoriasis and pustular psoriasis are severe conditions and the patient may be systemically unwell and febrile. NICE recommends that four key areas should be evaluated and recorded when assessing patients: severity, using the static Physician's Global Assessment (sPGA); disease impact on physical, psychological and social wellbeing using the Dermatology Life Quality Index (DLQI); the presence of psoriatic arthritis; and comorbidities. Read More

Pediatr Dermatol 2016 Mar-Apr;33(2):e174-8

Department of Dermatology, School of Medical Sciences, Universidade de São Paulo, São Paulo, Brazil.

We report a child with Crohn's disease and infliximab-induced guttate psoriasis. We also performed a systematic literature review on this intriguing paradoxical phenomenon in children with inflammatory bowel disease. Read More

Cutis 2016 Feb;97(2):140-4

Geisinger Medical Center, Danville, Pennsylvania, USA.

Guttate psoriasis (GP) typically occurs following an acute infection such as streptococcal pharyngitis. It is thought to have a better prognosis than chronic plaque psoriasis (PP). This retrospective cohort study of 79 patients with GP aims to assess the likelihood of developing PP after the first episode of GP as well as compare clinical and laboratory data in patients with GP who do and do not develop PP. Read More

Postepy Dermatol Alergol 2015 Dec 11;32(6):455-8. Epub 2015 Dec 11.

Department of Dermatology, Venereology and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland Head of the Department: Prof. Waldemar Placek MD, PhD.

Introduction: The association of guttate psoriasis with a streptococcal throat infection and HLA-Cw*06 allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population.

Aim: To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA-Cw*06 allele in 70 patients with guttate psoriasis originating from northern Poland. Read More

Ann Dermatol 2015 Dec 7;27(6):738-43. Epub 2015 Dec 7.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University, Seoul, Korea.

Background: The phenotypic heterogeneity of psoriasis could be explained by the alternate activation of either T-helper (Th)-1- or Th-17-related cytokines. However, evidence directly supporting this hypothesis is scarce.

Objective: To characterize the expression of Th-1- and Th-17-related cytokines according to the morphological psoriasis phenotype: guttate vs. Read More

J Drugs Dermatol 2015 Oct;14(10):1133-6

Introduction: Psoriasis is a chronic, inflammatory autoimmune disease that affects about 3% of the general population in the United States with 17% suffering from moderate to severe psoriasis. The disease process is believed to be mediated by tumor necrosis factor (TNF)-α and cytokines secreted by specialized T-cell populations including Interleukin (IL)-17, IL-22, and Interferon (IFN) γ. IL-17 plays an important role in psoriasis. Read More

J Immunol Res 2015 25;2015:258430. Epub 2015 Aug 25.

Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Inciraltı, 35340 Izmir, Turkey.

Psoriasis is a chronic, recurrent, immune-mediated inflammatory disease and it can be provoked or exacerbated by a variety of different environmental factors, particularly infections and drugs. In addition, a possible association between vaccination and the new onset and/or exacerbation of psoriasis has been reported by a number of different authors. The aim of this study is to investigate the effects of influenza vaccination on patients with psoriasis. Read More

Am J Transl Res 2015 15;7(6):1081-94. Epub 2015 Jun 15.

Department of Laboratory Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine Nanjing 210014, Jiangsu Province, P. R. China.

The human cathelicidin LL-37 peptide is overexpressed in psoriasis and has been demonstrated to be a multifunctional modulator of innate immune response elements, including monocytes. Monocytes, categorized into three populations based on the cell surface expression of CD14 and CD16, are activated in psoriasis guttate and are commonly triggered by streptococcal infections. Peptidoglycan (PGN) is a major cell-wall component of streptococcus, and an increasing number of PGN-containing cells have been detected in psoriasis. Read More

Med J Malaysia 2015 Jun;70(3):177-81

Sultan Abdul Halim Hospital, Department of Dermatology, Jalan Lencongan Timur, Bandar Amanjaya, Amanjaya, Sungai Petani 08000, Malaysia.

Introduction: Psoriasis is a common, chronic, relapsing, immune-mediated inflammatory disease. Our objective is to review the clinical profile, co-morbidities, and outcome of patients with psoriasis.

Methods: This is a cross-sectional study of outpatient psoriasis patients attending the dermatology clinic, Hospital Sultan Abdul Halim (HSAH) between January 2012 and June 2014. Read More

W V Med J 2015 Jul-Aug;111(4):26-8

Guttate psoriasis is a less common form of psoriasis. It manifests with numerous small, teardrop shaped, scaly plaques on the trunk and extremities. The etiology includes both environmental and genetic factors. Read More

Pharmacogenomics J 2016 08 21;16(4):336-40. Epub 2015 Jul 21.

Dermatology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain.

Paradoxical psoriasiform reactions to anti-tumor necrosis factor α (TNFα) agents have been described. We aimed to study the association between these reactions and polymorphisms in genes previously associated with psoriasis or other autoimmune diseases. A total of 161 patients with plaque-type psoriasis treated with anti-TNFα drugs were genotyped for 173 single-nucleotide polymorphisms (SNPs) using the Illumina Veracode genotyping platform. Read More

G Ital Dermatol Venereol 2015 Oct 18;150(5):533-46. Epub 2015 Jun 18.

Department of Experimental and Clinical Medicine Institute of Dermatology University of Udine, Udine, Italy -

Beside to traditional use, dermoscopy is more and more used in the assessment of other "general" dermatologic conditions, namely scalp and hair disorders (trichoscopy), nails abnormalities (onychoscopy), skin infections and infestations (entomodermoscopy), and cutaneous inflammatory diseases (inflammoscopy). Among the list of new applications of dermoscopy, the study of inflammatory dermatoses is probably the most promising topic in terms of development and usefulness, considering the large number of such disorders and the frequent problems in their differential diagnosis which the dermatologist encounters in own daily clinical practice. In this paper, we report selected relatively common clinical differential diagnosis issues concerning inflammatory dermatoses (and some clinically related noninflammatory conditions), analysing them by a dermoscopic point of view in order to assist their noninvasive resolution according to the available literature data and our personal experience, including papulosquamous dermatoses (guttate psoriasis, pityriasis lichenoides chronica, pityriasis rosea, lichen planus, lymphomatoid papulosis, classic pityriasis rubra pilaris, papulosquamous sarcoidosis, disseminated forms of porokeratosis and papulosquamous chronic GVHD), dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides, subacute cutaneous lupus erythematosus), palmar psoriasis vs. Read More

J Pediatr Adolesc Gynecol 2015 Oct 23;28(5):e127-9. Epub 2014 Oct 23.

The Dermatology Group, PA, Longwood, Florida.

Background: Guttate psoriasis is frequently associated with a preceding pharyngeal or perianal streptococcal infection in children. Despite Group A beta-hemolytic streptococci (GABHS) being the most common cause of specific bacterial vulvovaginitis in prepubertal girls, there are no reports of streptococcal vulvovaginitis triggering guttate psoriasis.

Case: A five-year-old girl presented with guttate psoriasis following an episode of Streptococcal pyogenes vulvovaginitis. Read More

Postgrad Med J 2015 Jun 6;91(1076):309-14. Epub 2015 May 6.

Department of Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Background: Childhood-onset psoriasis (COP), a distinct clinical entity, may be associated with HLA-Cw6 positivity and metabolic and cardiovascular complications. There is some evidence that HLA-Cw6 positivity is associated with more extensive or severe disease and that positivity is lower in Asian patients than in Caucasians. We describe the clinical profile, prevalence of the HLA-Cw6 allele, metabolic syndrome (MetS) and vitamin D deficiency in Indian patients with COP. Read More

Artif Cells Nanomed Biotechnol 2016 Sep 28;44(6):1374-82. Epub 2015 Apr 28.

a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.

Psoriasis is a chronic disorder with erythematous scaly patches, which typically affects the exposed surfaces of the body and scalp. Various factors such as bacterial infection, genetic and environmental factors, and immune disorders play an important role in causing psoriasis. Different types of psoriasis can be observed, such as guttate psoriasis, inverse psoriasis, pustular psoriasis, and psoriatic arthritis. Read More

Int J Health Sci (Qassim) 2015 Jan;9(1):25-33

Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia.

Background: Nuclear factor-κB (NF-κB) and small ubiquitin-like modifier (SUMO4) are key transcription factors involved in the regulation of immune responses and apoptosis. The aim of this study is to test for the association of NF-κB and SUMO gene polymorphisms with the susceptibility and severity of psoriasis among Saudi cases.

Subjects And Methods: This is a case controlled study including 85 Saudi psoriasis patients in addition to 92 matched healthy unrelated controls from the same locality. Read More

Clin Exp Dermatol 2015 Oct 16;40(7):804-6. Epub 2015 Feb 16.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Italy.

Clinical differentiation between pityriasis lichenoides chronica (PLC) and guttate psoriasis (GP) may sometimes be a difficult task, which often requires histological analysis to reach a definitive diagnosis. In this study, PLC and GP lesions were examined using dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation and decrease the number of cases requiring biopsy. We found that the incidence of orange-yellowish structureless areas, focal dotted vessels and nondotted vessels was statistically significant in PLC, while the incidence of diffuse dotted vessels was statistically significant in GP. Read More

Ann Dermatol 2015 Feb 3;27(1):26-31. Epub 2015 Feb 3.

Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: The assessment of the severity of psoriasis is often subjective because of the lack of quantitative laboratory diagnostic tools. Histopathological examination is the most commonly performed procedure for psoriasis diagnosis; however, it is usually descriptive. Thus, there is currently no quantitative method of determining psoriasis severity. Read More

BMJ Case Rep 2015 Jan 30;2015. Epub 2015 Jan 30.

Department of Otolaryngology, Coimbra Hospital and University Centre, Coimbra, Portugal.

Psoriasis is a chronic and immune-mediated skin disease with a considerable negative impact on quality of life. The link between psoriasis, especially guttate psoriasis, and streptococcal infections, namely tonsillitis, has been studied for several years. Some authors have also suggested an association with other types of psoriasis, such as plaque psoriasis, which is the most common. Read More

J Eur Acad Dermatol Venereol 2016 Jan 11;30(1):78-82. Epub 2014 Nov 11.

Department of Dermatology, Hôpital Victor Dupouy Hospital, Argenteuil, France.

Background: Age of the patients and age of onset of psoriasis may have an impact on the disease. There is little information about psoriasis in elderly patients.

Objective: We evaluated epidemiological, clinical aspects, comorbidities and treatments of psoriasis in the elderly (>70 years) patients, and in patients with very late onset psoriasis (onset ≥ 70 years). Read More

J Eur Acad Dermatol Venereol 2014 Dec 14;28(12):1833-5. Epub 2014 Feb 14.

Department of Dermatology, DermaPark, Uden, The Netherlands.

Acta Derm Venereol 2015 Apr;95(4):457-61

Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

Epidemiological data in childhood psoriasis are accumulating. However, reliable information captured at onset is lacking. In a cross sectional study we recruited 109 children < 16 years within 12 months of psoriasis onset and explored the clinical characteristics. Read More

Pan Afr Med J 2014 14;17:273. Epub 2014 Apr 14.

Department of Internal Medicine, General Hospital of Larissa, Larissa, Greece.

J Eur Acad Dermatol Venereol 2015 Mar 8;29(3):415-24. Epub 2014 Sep 8.

1st Department of Dermatology/University Clinic, 'Andreas Syggros' Hospital, Athens, Greece.

Reactive arthritis (ReA) is an immune-mediated seronegative arthritis that belongs to the group of spondyloarthropathies and develops after a gastrointestinal or genitourinary system infection. The condition is considered to be characterized by a triad of symptoms (conjunctivitis, arthritis and urethritis) although a constellation of other manifestations may also be present. ReA is characterized by psoriasiform dermatological manifestations that may resemble those of pustular psoriasis and, similar to guttate psoriasis, is a post-infectious entity. Read More

Mediators Inflamm 2014 14;2014:268257. Epub 2014 Aug 14.

Department of Dermatology, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-729, Republic of Korea.

Psoriasis is a chronic inflammatory skin disease. It is assumed that the plaque phenotype of psoriasis is associated with T helper (Th) 1 immune response activation, while the guttate phenotype is associated with the Th17 immune response. Previous investigations of differences in the serum levels of cytokines relative to the clinical psoriatic phenotype have yielded conflicting results. Read More

Dermatology 2014 23;229(2):130-5. Epub 2014 Aug 23.

Service de Dermatologie, Hôpital Henri-Mondor, AP-HP, Créteil, France.

Background: Psoriasis is a common chronic immune-mediated disease resulting from interactions of a genetic background with environmental triggering factors such as stress and infection. So far, there is very limited information available about the impact of vaccine stimuli on psoriasis course.

Objective: To collect cases of psoriasis flares occurring after vaccination through a national survey. Read More

Crit Rev Ther Drug Carrier Syst 2014 ;31(4):331-64

Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India.

Psoriasis is a chronic, proliferative, and inflammatory skin disease with reactive abnormal epidermal differentiation and hyperproliferation that affects 2-3% of the global population. Various types of psoriasis have been identified by clinical outcomes such as skin biopsies and blood analysis: plaque psoriasis, flexural psoriasis, guttate psoriasis, pustular psoriasis, psoriatic arthritis, scalp psoriasis, nail psoriasis, and erythrodermic psoriasis. The major factors which may be considered as causes of psoriasis are bacterial infections or other infection triggers, genetics, environment, immune disorders, weather, stress triggers, and skin injury. Read More

Int J Dermatol 2015 Mar 29;54(3):290-4. Epub 2014 Jul 29.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objectives: There is a paucity of data regarding clinical differences between early-onset psoriasis (EOP) and late-onset psoriasis (LOP) in Asian populations. This study aimed to investigate clinical differences between EOP (onset at the age of <40 years) and LOP (onset at the age of ≥40 years) in Thai patients.

Methods: From 2002 until 2008, staff and residents in the Department of Dermatology, Siriraj Hospital, were asked to complete a questionnaire detailing the age of onset, family history of psoriasis, comorbid diseases, clinical features, nail and joint involvement, and severity of psoriasis in all psoriasis patients. Read More

Arch Pediatr 2014 Jul 13;21(7):778-86. Epub 2014 Jun 13.

Service de dermatologie, hôpital Victor-Dupouy, 69, rue du Lieutenant-Colonel-Prudhon, 95100 Argenteuil, France.

Psoriasis is a chronic inflammatory skin disease that can affect nearly 1% of children, even during the first months of life. Recently, a link with obesity has been demonstrated by a few studies. The most common clinical form is the plaque psoriasis type, which only affects 50% of children. Read More

J Family Med Prim Care 2014 Jan;3(1):29-32

Burdwan Medical College, West Bengal, India.

Context: Psoriasis has an impact on psychology of the patients. There is a dearth of studies regarding this field in eastern India.

Aims And Objectives: The primary objective of this study is to evaluate the psychiatric morbidity in psoriasis and secondary objective is to assess the morbidity in all eight dimensions of psychosocial and physical aspects, i. Read More

Adolesc Health Med Ther 2014 14;5:25-34. Epub 2014 Mar 14.

First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.

Psoriasis is a chronic inflammatory cutaneous disorder affecting 2%-4% of the world's population. The prevalence of the disease in childhood and adolescence ranges between 0.5% and 2%. Read More

Int J Dermatol 2014 Dec 2;53(12):1447-53. Epub 2014 Apr 2.

1st Department of Dermatology, University of Athens Medical School, Andreas Sygros Hospital, Athens, Greece.

Background: Childhood and adolescent psoriasis is not an uncommon disease, but epidemiological information from a large series of studies is still lacking.

Objective: Our purpose was to present the demographics, clinical features, and outcome of psoriasis appearing in Greek patients from infants up to adolescents.

Methods: We conducted a retrospective analysis of 842 children and adolescents who diagnosed with psoriasis over a period of twenty years. Read More

Br J Dermatol 2014 Aug 4;171(2):409-11. Epub 2014 Aug 4.

Faculty of Life Sciences, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, U.K.

Background: An episode of guttate psoriasis can be an isolated event, can recur as guttate episodes, or develop into chronic plaque psoriasis (CPP). A previous study revealed that early-onset (before age 40 years) CPP is associated with inhibition of epidermal Langerhans cell (LC) migration.

Objectives: To determine whether guttate psoriasis is also associated with abnormal LC mobilization. Read More

Autoimmun Rev 2014 Apr-May;13(4-5):490-5. Epub 2014 Jan 13.

VA Sacramento Medical Center, Department of Veterans Affairs, Northern California Health Care System, Mather, CA, United States of America; Department of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA, United States of America. Electronic address:

Psoriasis is a chronic inflammatory multi organ disease with well characterized pathology occurring in the skin and often the joints. Although the disease has many characteristic and even pathognomonic features, no established diagnostic criteria exist for cutaneous psoriasis and there is no unified classification for the clinical spectrum of the disease. Prior approaches that have been taken to classify psoriasis include age of onset, severity of the disease, and morphologic evaluation. Read More

Ann Dermatol 2013 Nov 30;25(4):489-92. Epub 2013 Nov 30.

Department of Dermatology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Since the introduction of H1N1 influenza vaccine in the wake of the 2009 H1N1 pandemic, many serious and non-serious vaccine-related adverse events have been reported. The vaccination could induce pain, erythema, tenderness, and induration on injected areas. These symptoms usually disappear in a few days after the vaccination. Read More

J Dermatolog Treat 2014 Dec 27;25(6):482-6. Epub 2013 Nov 27.

Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco Medical Center , San Francisco, CA , USA .

Psoriasis is a chronic skin disorder that affects 1% to 3% of the general population worldwide. Streptococcal infection, especially streptococcal pharyngitis, has been shown to be a significant trigger of psoriasis in some patients, possibly by sensitizing T cells to keratin epitopes in the skin. Due to the role of the palatine tonsils as an immunological organ that may generate autoreactive T cells, tonsillectomy has been investigated as a treatment for psoriasis. Read More

Cochrane Database Syst Rev 2013 Oct 23(10):CD009481. Epub 2013 Oct 23.

Department of Dermatology & Venereology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041.

Background: The most commonly used types of phototherapy for treating psoriasis are narrow-band ultraviolet B (NB-UVB); broad-band ultraviolet B (BB-UVB), which includes selective (delivering radiation with a wavelength range of 305 to 325 nm) and conventional BB-UVB (280 to 320 nm); and psoralen ultraviolet A photochemotherapy (oral or bath PUVA). There is substantial controversy regarding their efficacy when compared with each other.

Objectives: To assess the effects of narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen ultraviolet A photochemotherapy for psoriasis. Read More