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Clin Med (Lond) 2021 05;21(3):170-173

St John's Institute of Dermatology, London, UK

Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population affected in the UK. Read More

Med Lav 2021 Apr 20;112(2):168-170. Epub 2021 Apr 20.

Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit - Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

Introduction: Chemical burns are a risk in domestic and occupational accidents due to the common use of caustic agents. Long-term sequelae are normally due to the amount of skin and underlying tissues damaged. We describe a case of work-related chemical burns with unusual evolution in guttate psoriasis. Read More

JAMA Dermatol 2021 Apr 14. Epub 2021 Apr 14.

Division of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Importance: Psoriasis is a heterogeneous disease. Improved understanding of prognosis and long-term outcomes in new-onset psoriasis may improve care.

Objective: To describe the clinical course of psoriasis and identify possible indicators of long-term outcomes. Read More

Eur J Histochem 2021 Mar 5;65(1). Epub 2021 Mar 5.

Department of Biomedical Sciences for Health, University of Milan.

This pilot study was aimed at comparing TLR7/TLR9 expression, cytoskeletal arrangement, and cell proliferation by indirect immunofluorescence in parallel lesional and non lesional skin samples of guttate psoriasis (PG) and psoriasis vulgaris (PV) in five male patients for each group (n=10). TLR7 expression was detected throughout all the epidermal compartment in PV samples, while in PG skin was restricted to the granular layer. TLR9 was present in the granular layer of non lesional skin and in the suprabasal layers of PV/PG lesional skin. Read More

Int J Dermatol 2021 Mar 2. Epub 2021 Mar 2.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dermatol Pract Concept 2021 Jan 29;11(1):e2021138. Epub 2021 Jan 29.

Department of Pathology, HBT Medical College & Dr. R.N. Cooper Hospital, Mumbai, India.

Background: Guttate psoriasis (GP) and pityriasis rosea (PR) are a part of papulosquamous disorders that have very similar clinical features and often require histopathology to confirm the diagnosis. Dermoscopy has emerged as a noninvasive, cost-effective technique that can aid in the diagnosis of inflammatory skin diseases like GP and PR.

Objective: To study and compare the dermoscopic features of GP and PR. Read More

Int J Mol Sci 2021 Feb 3;22(4). Epub 2021 Feb 3.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.

(CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA cutaneous lymphocyte antigen (CLA) T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, = 52), and also healthy individuals ( = 17). Read More

Vaccine 2021 02 21;39(8):1339-1348. Epub 2021 Jan 21.

The Emmes Corporation, Rockville, MD, United States.

Background: The number of human influenza A (H7N9) infections has escalated since 2013 with high resultant mortality. We conducted a phase II, randomized, partially-blinded trial to evaluate the safety and immunogenicity of an MF59-adjuvanted inactivated, split virion, H7N9 influenza vaccine (H7N9 IIV) administered at various dose levels and schedules in older adults.

Methods: 479 adults ≥ 65 years of age in stable health were randomized to one of six groups to receive either 3. Read More

Am J Clin Dermatol 2021 May 18;22(3):339-347. Epub 2021 Jan 18.

Department of Dermatology, National Taiwan University Hospital, No. 7 Chung San South Road, Taipei City, Taiwan.

Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. Read More

Dermatol Ther 2020 Dec 27:e14718. Epub 2020 Dec 27.

San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Psoriasis has been reported to be rare in people with skin of color. However, the actual prevalence is probably underestimated by the lack of wide epidemiological studies. The aim of the study is to present our experience in Tigray, Ethiopia, focusing on the issues related to diagnosis, clinical features and therapies. Read More

Ther Adv Musculoskelet Dis 2020 8;12:1759720X20975915. Epub 2020 Dec 8.

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.

Spondyloarthritides (SpA) like psoriatic arthritis, axial spondyloarthritis/ankylosing spondylitis, reactive arthritis and inflammatory bowel disease (IBD)-associated SpA can present with characteristic skin manifestations. These SpA-associated skin disorders may precede joint involvement, reflect a loss of efficacy of a current systemic treatment or can even be treatment associated. Cutaneous manifestations in SpA not only add additional morbidity with physical impact but also impose a psychosocial burden on affected patients. Read More

J Am Acad Dermatol 2021 May 3;84(5):1310-1320. Epub 2020 Dec 3.

Second Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Immune checkpoint inhibitor (ICI)-mediated psoriasis poses significant diagnostic and therapeutic challenges.

Objective: To report data on ICI-mediated psoriasis, emerging from the largest cohort to date, to our knowledge, and to propose a step-by-step management algorithm.

Methods: The medical records of all patients with ICI-mediated psoriasis were retrospectively reviewed across 9 institutions. Read More

Dermatol Ther 2021 01 13;34(1):e14631. Epub 2020 Dec 13.

Department of Dermatology, Venereology and Leprosy, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, India.

Dermoscopy as a diagnostic tool is attaining impetus in inflammatory dermatoses with the cumulative description of characteristic findings in most dermatoses obviating at times the need of biopsy. In this retrospective observational study, 20 histopathology confirmed cases each of pityriasis rosea (PR), guttate psoriasis (GP), and pityriasis lichenoides chronica (PLC) seen over a period of 3 years were included. Dermoscopy images were extracted from photography archives for evaluation and three lesions from each patient (60 lesions each) were analyzed. Read More

Cureus 2020 Oct 27;12(10):e11206. Epub 2020 Oct 27.

Dermatology, St. Anthony Hospital, Oklahoma City, USA.

Lichen planus (LP) is a chronic inflammatory disease that affects the skin, hair, nails, and mucous membranes, with variants such as drug-induced lichen planus, which is triggered by medications such as angiotensin-converting enzyme (ACE) inhibitors and antimalarials. Guttate psoriasis (GP), a clinical variant of psoriasis, is associated with streptococcal infections and presents with drop-like papules on the trunk and proximal extremities. In this report, we present a case of LP in an atypical location masquerading as GP and the importance of prompt dermatological referral to improve the patient's quality of life. Read More

Chin Med J (Engl) 2020 Nov 9;133(24):3004-3006. Epub 2020 Nov 9.

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

Front Immunol 2020 1;11:571319. Epub 2020 Oct 1.

Laboratory of Human Microbiome and Longevity, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.

Background: Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota are important drivers of proinflammatory disorders and could play a role in the pathogenesis of psoriasis. Therefore, we explored whether psoriasis in a Central Asian cohort is associated with alterations in select immunological markers and/or microbiota of the gut. Read More

Australas J Dermatol 2020 Nov 6;61(4):e481-e484. Epub 2020 Jul 6.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

Life (Basel) 2020 Aug 21;10(9). Epub 2020 Aug 21.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

Abnormal histone modification by histone deacetylases (HDACs), including HDAC1 and sirtuin 1 (SIRT1), has been reported to play an important role in the pathogenesis of psoriasis by altering cell proliferation, differentiation, and inflammation. However, findings on the expression level of HDACs in psoriatic skin lack consistency. We assessed the expression of HDAC1, SIRT1, p63, and proliferating cell nuclear antigen (PCNA) in skin tissues from 23 patients with psoriasis (15 with plaque psoriasis and eight with guttate psoriasis) and five healthy individuals using immunohistochemistry, and analyzed their associations with clinical phenotypes of the disease. Read More

BMJ Case Rep 2020 08 11;13(8). Epub 2020 Aug 11.

Gastroenterology, Homerton University Hospital NHS Foundation Trust, London, UK

Clin Exp Dermatol 2021 Jan 29;46(1):65-73. Epub 2020 Aug 29.

Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.

Background: While the majority of children with a chronic itchy rash suffer from atopic dermatitis (AD) and other forms of dermatitis, psoriasis is in the differential diagnosis. Certain patterns such as guttate and napkin psoriasis are accepted as classic paediatric psoriasis (PP); however, there are many patients who do not fit these classic forms of PP nor fulfil the accepted criteria for AD. 'Psoriasiform dermatitis' (PD) is a term that has been used for these patients; however, it has not been formally defined. Read More

Int J Trichology 2020 Mar-Apr;12(2):93-96. Epub 2020 May 5.

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Low-dose methotrexate (MTX) is the backbone of treatment for extensive psoriasis vulgaris not responding to topical therapy. Since its induction for the treatment of psoriasis in the 1970, its short- and long-term side effect profile has been extensively studied. Hair loss with MTX has been reported mostly with high-dose MTX used in chemotherapy. Read More

Indian Pediatr 2020 06;57(6):596-597

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy and Medical Sciences, Peking Union Medical College, Beijing, China.

Dermatopathology (Basel) 2019 Oct-Dec;6(4):237-240. Epub 2020 Jan 17.

Division of Pediatric Allergy, Immunology and Rheumatology, University of California Davis Health, Sacramento, California, USA.

Contact dermatitis and psoriasis are common skin disorders which represent two distinct pathologies. Skin disorders heavily rely on corresponding history for diagnosis; this case demonstrates the challenges of relying on history alone for final identification. A patient presented to clinic for evaluation of a new rash on his abdomen. Read More

J Invest Dermatol 2020 07 21;140(7):1364-1370.e1. Epub 2020 Jan 21.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. Read More

Cutis 2019 Oct;104(4):248-249

57 West Dermatology, New York, New York, USA.

Guttate psoriasis is a variant of psoriasis characterized by small, 2- to 10-mm, raindroplike lesions on the skin. Guttate psoriasis is commonly triggered by group A streptococcal pharyngitis. We describe a novel case of guttate psoriasis following presumed coxsackievirus A hand-foot-and-mouth disease (HFMD). Read More

J Dtsch Dermatol Ges 2019 Sep;17(9):959-973

Department of Dermatology, Erlangen University Medical Center, Erlangen, Germany.

The present guidelines are aimed at residents and board-certified physicians in the fields of dermatology, pediatrics, pediatric dermatology and pediatric rheumatology as well as policymakers and insurance funds. They were developed by dermatologists and pediatric dermatologists in collaboration with pediatric rheumatologists using a formal consensus process (S2k). The guidelines highlight topics such as disease severity, quality of life, treatment goals as well as problems associated with off-label drug therapy in children. Read More

Postgrad Med J 2020 Mar 11;96(1133):139-143. Epub 2019 Sep 11.

Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

Objective: Although patients with psoriasis frequently report seasonal changes in their symptoms, the seasonality of psoriasis has rarely been explored. This study aims to investigate the seasonal pattern of and global public interest in psoriasis using Google search data.

Methods: Internet search data were collected from Google Trends. Read More

Expert Rev Clin Pharmacol 2019 Oct 30;12(10):981-989. Epub 2019 Sep 30.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei , Taiwan.

: Psoriasis is affected by many environmental factors, including infections and antibiotics. However, the relationship between antibiotics and psoriasis is inadequately studied. Some antibiotics were listed as triggering factors; others showed benefit for psoriasis control. Read More

J Dtsch Dermatol Ges 2019 Aug;17(8):856-870

Department of Dermatology, Erlangen University Medical Center, Erlangen, Germany.

The present guidelines are aimed at residents and board-certified physicians in the fields of dermatology, pediatrics, pediatric dermatology and pediatric rheumatology as well as policymakers and insurance funds. They were developed by dermatologists and pediatric dermatologists in collaboration with pediatric rheumatologists using a formal consensus process (S2k). The guidelines highlight topics such as disease severity, quality of life, treatment goals as well as problems associated with off-label drug therapy in children. Read More

J Drugs Dermatol 2019 Aug;18(8):822-823

Guttate psoriasis is an acute subtype of plaque psoriasis characterized by eruption of small, scaly plaques, and papules, 5 to 10 mm in size over the trunk and proximal extremities.1 It often arises in children and young adults concomitantly with or shortly after a streptococcal throat infection or tonsillitis. Patients with chronic plaque psoriasis can also experience guttate flares following streptococcal throat infections. Read More