364 results match your criteria Guttate Psoriasis


Guttate Psoriasis.

Indian Pediatr 2020 Jun;57(6):596-597

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy and Medical Sciences, Peking Union Medical College, Beijing, China.

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At First Glance: Psoriatic Response to Transdermal Nicotine Patch Application.

Dermatopathology (Basel) 2019 Oct-Dec;6(4):237-240. Epub 2020 Jan 17.

Division of Pediatric Allergy, Immunology and Rheumatology, University of California Davis Health, Sacramento, California, USA.

Contact dermatitis and psoriasis are common skin disorders which represent two distinct pathologies. Skin disorders heavily rely on corresponding history for diagnosis; this case demonstrates the challenges of relying on history alone for final identification. A patient presented to clinic for evaluation of a new rash on his abdomen. Read More

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http://dx.doi.org/10.1159/000505357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011772PMC
January 2020

Specific IgA and CLA T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis.

J Invest Dermatol 2020 Jul 21;140(7):1364-1370.e1. Epub 2020 Jan 21.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. Read More

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http://dx.doi.org/10.1016/j.jid.2019.12.022DOI Listing

Guttate psoriasis following presumed coxsackievirus A.

Cutis 2019 Oct;104(4):248-249

57 West Dermatology, New York, New York, USA.

Guttate psoriasis is a variant of psoriasis characterized by small, 2- to 10-mm, raindroplike lesions on the skin. Guttate psoriasis is commonly triggered by group A streptococcal pharyngitis. We describe a novel case of guttate psoriasis following presumed coxsackievirus A hand-foot-and-mouth disease (HFMD). Read More

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October 2019

S2k guidelines for the treatment of psoriasis in children and adolescents - Short version part 2.

J Dtsch Dermatol Ges 2019 Sep;17(9):959-973

Department of Dermatology, Erlangen University Medical Center, Erlangen, Germany.

The present guidelines are aimed at residents and board-certified physicians in the fields of dermatology, pediatrics, pediatric dermatology and pediatric rheumatology as well as policymakers and insurance funds. They were developed by dermatologists and pediatric dermatologists in collaboration with pediatric rheumatologists using a formal consensus process (S2k). The guidelines highlight topics such as disease severity, quality of life, treatment goals as well as problems associated with off-label drug therapy in children. Read More

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http://dx.doi.org/10.1111/ddg.13936DOI Listing
September 2019
3 Reads

Seasonality and global public interest in psoriasis: an infodemiology study.

Postgrad Med J 2020 Mar 11;96(1133):139-143. Epub 2019 Sep 11.

Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

Objective: Although patients with psoriasis frequently report seasonal changes in their symptoms, the seasonality of psoriasis has rarely been explored. This study aims to investigate the seasonal pattern of and global public interest in psoriasis using Google search data.

Methods: Internet search data were collected from Google Trends. Read More

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http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2019-1367
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http://dx.doi.org/10.1136/postgradmedj-2019-136766DOI Listing
March 2020
3 Reads

A review of antibiotics and psoriasis: induction, exacerbation, and amelioration.

Expert Rev Clin Pharmacol 2019 Oct 30;12(10):981-989. Epub 2019 Sep 30.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei , Taiwan.

: Psoriasis is affected by many environmental factors, including infections and antibiotics. However, the relationship between antibiotics and psoriasis is inadequately studied. Some antibiotics were listed as triggering factors; others showed benefit for psoriasis control. Read More

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http://dx.doi.org/10.1080/17512433.2019.1665027DOI Listing
October 2019
2 Reads

S2k guidelines for the treatment of psoriasis in children and adolescents - Short version part 1.

J Dtsch Dermatol Ges 2019 Aug;17(8):856-870

Department of Dermatology, Erlangen University Medical Center, Erlangen, Germany.

The present guidelines are aimed at residents and board-certified physicians in the fields of dermatology, pediatrics, pediatric dermatology and pediatric rheumatology as well as policymakers and insurance funds. They were developed by dermatologists and pediatric dermatologists in collaboration with pediatric rheumatologists using a formal consensus process (S2k). The guidelines highlight topics such as disease severity, quality of life, treatment goals as well as problems associated with off-label drug therapy in children. Read More

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http://dx.doi.org/10.1111/ddg.13907DOI Listing
August 2019
7 Reads

Resolution of Guttate Psoriasis Plaques After One-time Administration of Guselkumab

J Drugs Dermatol 2019 Aug;18(8):822-823

Guttate psoriasis is an acute subtype of plaque psoriasis characterized by eruption of small, scaly plaques, and papules, 5 to 10 mm in size over the trunk and proximal extremities.1 It often arises in children and young adults concomitantly with or shortly after a streptococcal throat infection or tonsillitis. Patients with chronic plaque psoriasis can also experience guttate flares following streptococcal throat infections. Read More

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August 2019
4 Reads

Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review.

Clin Rev Allergy Immunol 2019 Oct;57(2):294-302

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Streptococcus A infections have been associated with immune-mediated sequelae including acute glomerulonephritis, acute rheumatic fever, thrombocytopenia, hemolytic anemia, Henoch-Schönlein purpura, arthritis, uveitis, guttate psoriasis, and erythema nodosum. Available reviews do not report the occurrence of acute poststreptococcal glomerulonephritis in association with one of the mentioned conditions. We performed a systematic review of the literature on extrarenal immune-mediated disorders associated with acute poststreptococcal glomerulonephritis. Read More

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http://dx.doi.org/10.1007/s12016-019-08761-wDOI Listing
October 2019
9 Reads

Circulating levels of chemokines in patients with psoriasis vulgaris and their association with disease severity: A case-control study from North India.

Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):567

Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and incomplete differentiation of epidermis, and accumulation of neutrophils and proinflammatory T cells in epidermis and dermis. Chemokines are believed to be the main players mediating the chemotaxis of leucocytes to the lesional site. Previous studies have established the role of various chemokine ligands and receptors at the lesional site in psoriasis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_392_18DOI Listing
May 2020
4 Reads
1.325 Impact Factor

Acute onset of psoriatic spondyloarthritis as a new manifestation of post-streptococcal reactive arthritis: a case series.

Clin Rheumatol 2019 Sep 22;38(9):2367-2372. Epub 2019 Jul 22.

Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Streptococcus is well associated with a myriad of inflammatory diseases. Among others, this bacterium is linked to the triggering of psoriasis and to post-streptococcal reactive arthritis (PSRA), an arthritis which is typically confined to peripheral joints. Three patients who developed acute psoriatic spondyloarthritis (SpA) following a recent streptococcal infection are described in this article. Read More

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http://dx.doi.org/10.1007/s10067-019-04695-yDOI Listing
September 2019
7 Reads

A case of guttate psoriasis during treatment with dupilumab.

Dermatol Ther 2019 09 30;32(5):e12998. Epub 2019 Jun 30.

Institute of Dermatology, Catholic University-Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

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http://dx.doi.org/10.1111/dth.12998DOI Listing
September 2019
5 Reads

Lichen Sclerosus on the Sites of Striae Distensae and a Surgical Scar in a Patient with Coexistent Morphea.

Acta Dermatovenerol Croat 2019 Mar;27(1):44-46

Sevkiye Copur, MD, Department of Dermatology & Venereology, Istanbul University, Istanbul Medical Faculty , Millet Street (Caddesi), 34093 Capa , Istanbul, Turkey;

Lichen sclerosus (LS), also known as lichen sclerosus et atrophicus, is a chronic inflammatory mucocutaneous disease affecting the genital and/or extragenital areas. Although LS usually occurs alone, its coexistence in morphea patients has been reported in 5.7% and 38. Read More

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March 2019
15 Reads

Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.

Clin Dermatol 2019 Mar - Apr;37(2):160-166. Epub 2019 Jan 16.

Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; Departments of Pathology and Social Sciences & Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Psoriasis is associated with a higher incidence of Crohn disease and periodontitis, two diseases involving impaired tolerance and abnormal immune activation in response to intestinal and oral microbiota, respectively. In addition, guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.01.011DOI Listing
September 2019
18 Reads

WITHDRAWN: Interventions for guttate psoriasis.

Cochrane Database Syst Rev 2019 04 9;4:CD001213. Epub 2019 Apr 9.

The Dermatology Centre, The University of Manchester, Salford Royal NHS Foundation Trust, Stott Lane, Salford, Manchester, UK, M6 8HD.

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. Very little specific evidence-based guidance is available in standard texts to help make rational decisions about treatment options.

Objectives: To assess the effectiveness of treatments for guttate psoriasis. Read More

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http://doi.wiley.com/10.1002/14651858.CD001213.pub2
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http://dx.doi.org/10.1002/14651858.CD001213.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454586PMC
April 2019
11 Reads

Non-antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis.

Cochrane Database Syst Rev 2019 04 8;4:CD011541. Epub 2019 Apr 8.

Department of Dermatology, Université François-Rabelais de Tours, Tours, France, 37044.

Background: Guttate psoriasis displays distinctive epidemiological and clinical features, making it a separate entity within the heterogeneous group of cutaneous psoriasis types. It is associated with genetic, immune, and environmental factors (such as stress and infections) and usually arises in younger age groups (including children, teenagers, and young adults). There is currently no cure for psoriasis, but various treatments can help to relieve the symptoms and signs. Read More

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http://dx.doi.org/10.1002/14651858.CD011541.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452774PMC
April 2019
3 Reads

Low Dose Naltrexone in Dermatology

J Drugs Dermatol 2019 Mar;18(3):235-238

Low-dose naltrexone (LDN) has been successfully studied as an immunomodulatory and anti-inflammatory therapy in a wide range of conditions including Crohn’s disease, fibromyalgia, major depressive disorder, cancer, chronic regional pain syndrome, Charcot-Marie-Tooth, and multiple sclerosis.1-5 Recently, off label LDN has been shown to improve dermatologic conditions such as systemic sclerosis, Hailey-Hailey Disease, lichen planopilaris, and guttate psoriasis.6-9 In this article, we examine the existing evidence for use of LDN in skin disease and discuss its potential application in the treatment of atopic dermatitis (AD). Read More

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March 2019
8 Reads

WITHDRAWN: Antistreptococcal interventions for guttate and chronic plaque psoriasis.

Cochrane Database Syst Rev 2019 03 6;3:CD001976. Epub 2019 Mar 6.

Royal Blackburn Hospital, Haslingden Road, Blackburn, UK, BB2 3HH.

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. It is closely associated with preceding streptococcal sore throat or tonsillitis. Some authorities have claimed that ordinary (chronic plaque) psoriasis may also be made worse by infection at distant sites. Read More

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http://doi.wiley.com/10.1002/14651858.CD001976.pub2
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http://dx.doi.org/10.1002/14651858.CD001976.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402274PMC
March 2019
50 Reads

Antistreptococcal interventions for guttate and chronic plaque psoriasis.

Cochrane Database Syst Rev 2019 03 5;3:CD011571. Epub 2019 Mar 5.

Department of Immuno-Allergology, CHU Brugmann, Place A.Van Gehuchten 4, Brussels, Belgium, 1020.

Background: Psoriasis is a chronic skin disease that affects approximately two per cent of the general population. Plaque psoriasis is the most common form: it usually appears as raised, red patches of inflamed skin, covered with silvery white scales. The patches often occur in a symmetrical pattern. Read More

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http://doi.wiley.com/10.1002/14651858.CD011571.pub2
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http://dx.doi.org/10.1002/14651858.CD011571.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400423PMC
March 2019
39 Reads

Diagnosis and Management of Cutaneous Psoriasis: A Review.

Adv Skin Wound Care 2019 Feb;32(2):58-69

Alisa Brandon, MSc • Medical Student • University of Toronto • Toronto, Ontario, Canada Asfandyar Mufti, MD • Dermatology Resident • University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, DSc (Hons), MD, MEd, BSc, FRCPC (Med Derm), ABIM, FAAD, MAPWCA • Professor • Medicine and Public Health • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course and Masters of Science in Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Editor-in-Chief • Advances in Skin and Wound Care • Philadelphia, Pennsylvania.

General Purpose: To provide information about the diagnosis and management of cutaneous psoriasis.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After completing this continuing education activity, the provider should be better able to: ABSTRACT: Psoriasis is a chronic inflammatory disease that is characterized by plaque, inverse, guttate, pustular, and erythrodermic variants. Read More

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http://dx.doi.org/10.1097/01.ASW.0000550592.08674.43DOI Listing
February 2019
39 Reads
1.634 Impact Factor

A cross-sectional study of the distribution of psoriasis subtypes in different ethno-racial groups.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

Department of Dermatology, University of California-San Francisco, San Francisco, California.

Skin of colored patients with psoriasis are more likely to remain undiagnosed and experience a greater impact on quality of life than their white counterparts. A better understanding of the ethno-racial differences in the presentation of psoriasis can help address these disparities. To compare the prevalence of psoriatic subtypes (plaque, guttate, pustular, erythrodermic, palmoplantar, and inverse) and lesion locations in Caucasian, Asian, and Hispanic/Latino patients, we analyzed cross-sectional, patient-reported, physician-reviewed survey data from 882 adult and 16 pediatric psoriasis patients seen at the University of California, San Francisco Department of Dermatology between 2006 and 2016. Read More

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July 2018
46 Reads

Linear Lichen Planus in the Setting of Annual Vaccination.

Mil Med 2019 05;184(5-6):e467-e469

Dartmouth-Hitchcock, One Medical Center Drive, Lebanon, NH.

Vaccines have a well-demonstrated therapeutic benefit. However, the spectrum of potential dermatologic vaccine side effects ranges from localized skin irritation to acute and delayed response. Currently, there are limited published data correlating dermatoses with alterations in the immune system following vaccination. Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usy234DOI Listing
May 2019
40 Reads

The distinct role and regulatory mechanism of IL-17 and IFN-γ in the initiation and development of plaque vs guttate psoriasis.

J Dermatol Sci 2018 Oct 7;92(1):106-113. Epub 2018 Jul 7.

Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address:

Background: Few studies have explored the differences of immunopathogenesis in plaque vs guttate psoriasis, especially on the inhibitory role of regulatory T cells (Tregs) on IL-17/ IFN-γ production and the impact of CD4+T cells on keratinocytes.

Objective: To investigate the percentage and inhibitory function of CD4+CD25Treg and differential expressions of IL-17/ IFN-γ in plaque vs guttate psoriasis, and the effects of CD4+T cells on the proliferation of keratinocytes.

Methods: Peripheral blood mononuclear cells (PBMCs) were prepared from patients with the plaque and guttate psoriasis. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.07.001DOI Listing
October 2018
37 Reads

Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis: A Case Report.

Int J Pharm Compd 2018 Jul-Aug;22(4):270-278

Retired compounding pharmacist, Hammond, Louisiana.

The ancient autoimmune skin condition psoriasis is still ubiquitous worldwide, produces the same, often-intolerable effects noted in its earliest recorded descriptions, and remains without cure. Management options designed to resolve the itchy, scaly, weeping, erythematous, and often widespread lesions of that disorder are now available, but they vary in efficacy, most are associated with the development of severe adverse effects, and many are prohibitively expensive. In this article, we describe the successful use of a compounded formulation of oral low-dose naltrexone to manage guttate psoriasis in a 75-year-old white male patient. Read More

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September 2018
9 Reads

CLA T Cell Response to Microbes in Psoriasis.

Front Immunol 2018 27;9:1488. Epub 2018 Jun 27.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.

throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA) positive (+) memory T cells are a subset of peripheral lymphocytes whose phenotype and function are related to immunological mechanisms in the skin. These cells are considered peripheral biomarkers of T-cell-mediated skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036263PMC
June 2018
23 Reads

Identifying a Core Domain Set to Assess Psoriasis in Clinical Trials.

JAMA Dermatol 2018 10;154(10):1137-1144

Department of Dermatology, Keck School of Medicine of University of Southern California, Los Angeles.

Importance: There is no consensus on which domains should be measured or which instruments should be used in clinical trials for psoriasis therapies.

Objective: To achieve international consensus among psoriasis stakeholders on a core set of domains that should be measured in all psoriasis clinical trials.

Design, Setting, And Participants: Literature review, pre-Delphi survey exercises, nominal group discussions, and audience voting at 4 stakeholder meetings were used to develop candidate domains for 2 rounds of a Delphi survey. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.1165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233740PMC
October 2018
7 Reads

Epidemiology and Clinical Features of Adult Patients with Psoriasis in Malaysia: 10-Year Review from the Malaysian Psoriasis Registry (2007-2016).

Dermatol Res Pract 2018 23;2018:4371471. Epub 2018 Apr 23.

Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the general population.

Aim: To evaluate the epidemiology and clinical characteristics of patients with psoriasis who seek treatment in outpatient dermatology clinics throughout hospitals in Malaysia.

Materials And Methods: Data were obtained from the Malaysian Psoriasis Registry (MPR). Read More

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https://www.hindawi.com/journals/drp/2018/4371471/
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http://dx.doi.org/10.1155/2018/4371471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937568PMC
April 2018
49 Reads

Association of the novel susceptible locus rs9266150 with clinical features of psoriasis vulgaris in the Chinese Han population.

Exp Dermatol 2018 07;27(7):748-753

Department of Dermatology, Institute of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, China.

Psoriasis is a chronic multifactorial disease and is considered to be strongly associated with the major histocompatibility complex (MHC) region. We have discovered an independent, novel and susceptible psoriasis risk HLA loci, rs9266150; P = 4.52 × 10 for the first time. Read More

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http://dx.doi.org/10.1111/exd.13554DOI Listing
July 2018
35 Reads
3.762 Impact Factor

Complete resolution of guttate psoriasis after tonsillectomy.

Ear Nose Throat J 2018 Mar;97(3):62-63

Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/014556131809700319DOI Listing
March 2018
34 Reads

Anti-Programmed Cell Death-1-Induced Plaque and Guttate Psoriasis.

Indian J Dermatol 2018 Jan-Feb;63(1):88-89

Department of Dermatology, Fukushima Medical University, Fukushima 960-1295, Japan. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_46_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838768PMC
March 2018
8 Reads

Is there a correlation of serum and tissue T helper-1 and -2 cytokine profiles with psoriasis activity and severity? A cross-sectional study.

Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):414-418

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Background: Previous studies correlating Th1 and Th2 cytokine profiles with psoriasis activity provided inconsistent results. Correlation of tissue cytokine levels with psoriasis severity has not been studied till now.

Objective: To compare serum and tissue Th1 and Th2 cytokine profiles of patients with active and stable psoriasis as well as healthy controls, and to correlate them with psoriasis severity. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_471_17DOI Listing
November 2018
14 Reads

Treatment of selective antibody deficiency with IVIG resulting in decreased frequency of streptococcal infection and improvement of guttate psoriasis.

Dermatol Online J 2017 08 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Saint Louis University, Saint Louis, Missouri.

The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

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August 2017
6 Reads

Unique urticarial presentation of minocycline-induced lupus erythematosus.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, University of California, Davis, Sacramento, CA USA, Department of Biological Sciences, California State Univeristy, Sacramento, CA USA.

The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. Read More

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August 2017
6 Reads

A secondary syphilis rash with scaly target lesions.

Oxf Med Case Reports 2018 Feb 1;2018(2):omx089. Epub 2018 Feb 1.

Microbiologie Médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.

A 40-year-old man reported a 5-day history of fever and malaise, followed by a pruritic generalized rash. He had well-demarcated erythematous papules and plaques with scaling. The patient was diagnosed with secondary syphilis. Read More

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http://dx.doi.org/10.1093/omcr/omx089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793725PMC
February 2018
11 Reads

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?

An Bras Dermatol 2017 Nov-Dec;92(6):826-829

Department of Dermatology, Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.

Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20175994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786398PMC
April 2018
17 Reads

Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese Society for Psoriasis Research.

J Dermatol 2018 Mar 8;45(3):293-301. Epub 2017 Nov 8.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

Since 1982, the Japanese Society for Psoriasis Research has conducted annual epidemiological surveys of patients with psoriasis. Kawada et al. have reported data for 1982-2001 and Takahashi et al. Read More

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http://doi.wiley.com/10.1111/1346-8138.14105
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http://dx.doi.org/10.1111/1346-8138.14105DOI Listing
March 2018
19 Reads

Anti-PD1/PDL1 induced psoriasis.

Curr Probl Cancer 2017 Nov - Dec;41(6):407-412. Epub 2017 Oct 18.

Dermato Oncology Department, Cutaneous Toxicities Clinic, Andreas Sygros Hospital, University of Athens, Athens, Greece.

Background: Immune checkpoint inhibitors are novel agents approved for the treatment of late-stage malignancies. Despite its important clinical benefits, checkpoint inhibition is associated with a unique spectrum of side effects known as immune-related adverse events. Skin toxicities are the most frequent immune-related adverse events during anti-PD1 blockade therapies. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2017.10.003DOI Listing
July 2018
14 Reads

HLA-Cw6 and psoriasis.

Authors:
L Chen T-F Tsai

Br J Dermatol 2018 04 2;178(4):854-862. Epub 2018 Mar 2.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan.

Psoriasis is a multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles. It is repeatedly observed to affect disease course, phenotypic features, severity, comorbidities and treatment outcomes. Read More

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http://dx.doi.org/10.1111/bjd.16083DOI Listing
April 2018
6 Reads

Microbe-Dependent Induction of IL-9 by CLA T Cells in Psoriasis and Relationship with IL-17A.

J Invest Dermatol 2018 03 17;138(3):580-587. Epub 2017 Oct 17.

Translational Immunology, Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Spain. Electronic address:

IL-9 is present in psoriatic lesions and is produced by lymphocytes. However, it is not known whether this cytokine is induced by relevant pathogenic triggers of psoriasis, such as Streptococcus pyogenes. Here we addressed the production of IL-9 in response to various pathogens in a psoriatic ex vivo model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X173305
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http://dx.doi.org/10.1016/j.jid.2017.08.048DOI Listing
March 2018
33 Reads

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan.

J Dermatol 2018 Mar 19;45(3):314-317. Epub 2017 Oct 19.

Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28. Read More

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http://dx.doi.org/10.1111/1346-8138.14101DOI Listing
March 2018
9 Reads

Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies.

J Leukoc Biol 2018 02 29;103(2):193-213. Epub 2017 Dec 29.

School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.

Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. Read More

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http://doi.wiley.com/10.1189/jlb.4MR0617-227RR
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http://dx.doi.org/10.1189/jlb.4MR0617-227RRDOI Listing
February 2018
26 Reads

Ustekinumab-induced remission of recalcitrant guttate psoriasis: A case series.

JAAD Case Rep 2017 Sep 1;3(5):432-435. Epub 2017 Sep 1.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.jdcr.2017.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594234PMC
September 2017
10 Reads

Paradoxical Side Effect Related With Anti-Tumor Necrosis Factor Alpha Treatment.

Med Arch 2017 Apr;71(2):148-150

Katip Celebi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Izmir, Turkey.

Introduction: Anti-tumor necrosis factor (anti-TNF) treatments are effective in controlling disease activity in many immune-mediated diseases such as psoriasis and ankylosing spondylitis (AS). Although side effects such as infection and skin reactions are predictable in anti-TNF treatment; susceptibility to psoriasis is considered as a paradoxical side effect.

Case Report: We report a case of forty-year-old male patient with 7 years of AS was taking anti-TNF therapy. Read More

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http://dx.doi.org/10.5455/medarh.2017.71.148-150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511539PMC
April 2017
16 Reads

The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE).

Ann Dermatol 2017 Aug 21;29(4):462-470. Epub 2017 Jun 21.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date.

Objective: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. Read More

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http://dx.doi.org/10.5021/ad.2017.29.4.462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500712PMC
August 2017
111 Reads

Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients.

Ann Dermatol 2017 Aug 21;29(4):422-426. Epub 2017 Jun 21.

Department of Dermatology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.

Background: Although phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines.

Objective: To investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy controls, and 2) between patients with different psoriasis phenotypes.

Methods: Twenty-five patients with psoriasis (10 with guttate psoriasis and 15 with plaque psoriasis) and 5 healthy volunteers were enrolled in this study. Read More

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http://dx.doi.org/10.5021/ad.2017.29.4.422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500706PMC
August 2017
19 Reads

Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.

Clin Rev Allergy Immunol 2017 Dec;53(3):371-393

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud's phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet's syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. Read More

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http://dx.doi.org/10.1007/s12016-017-8632-5DOI Listing
December 2017
104 Reads

Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population.

J Gene Med 2017 Sep 19;19(9-10). Epub 2017 Sep 19.

Institute of Dermatology and Department of Dermatology the first Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Background: The human major histocompatibility complex (MHC) is known to be highly polymorphic and has been identified to be associated with numerous diseases. The HLA-DPB1 and BTNL2 genes were associated with psoriasis for the first time. The present study aims to investigate the relevance of the HLA-DPB1 and BTNL2 genes with respect to clinical phenotypes of psoriasis vulgaris (PV). Read More

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http://dx.doi.org/10.1002/jgm.2961DOI Listing
September 2017
25 Reads
2.470 Impact Factor

Guttate psoriasis triggered by perianal streptococcal infection.

Clin Exp Dermatol 2017 Jul 22;42(5):536-538. Epub 2017 May 22.

Department of Dermatology, University Medical Center Utrecht, Wilhelmina Children's Hospital, the Netherlands.

The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Read More

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http://dx.doi.org/10.1111/ced.13129DOI Listing
July 2017
4 Reads