417 results match your criteria Gut Pathogens [Journal]


Prevalence and molecular determinants of colistin resistance among commensal Enterobacteriaceae isolated from poultry in northwest of Iran.

Gut Pathog 2019 31;11. Epub 2019 Jan 31.

2Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University of Tabriz, Tabriz, Iran.

Background: The emergence of colistin-resistant Enterobacteriaceae from human and animal sources is a public health concern as this antibiotic is considered to be the last line therapeutic option for infections caused by multidrug-resistant Gram-negative bacteria. Here we aimed to determine the prevalence of colistin resistance, among enterobacteria isolated from poultry and the possible underlying colistin resistance mechanisms.

Methods: A collection of 944 cloacal samples were obtained from poultry and screened for colistin resistance. Read More

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http://dx.doi.org/10.1186/s13099-019-0282-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354369PMC
January 2019
2 Reads
2.070 Impact Factor

Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma.

Gut Pathog 2019 18;11. Epub 2019 Jan 18.

1Department of Microbiology, Key Laboratory of Pathogen of Jiangsu Province, Nanjing Medical University, Nanjing, China.

Background: The onset of hepatocellular carcinoma (HCC) ranked fifth malignancies all over the world. Increasing evidences showed that the distribution of HCC was related to the incidence of chronic hepatitis B virus (HBV) infection and other factors, such as alcoholism, aflatoxin B1 ingestion and obesity. Recent studies demonstrated that gut dysbiosis plays an important role in liver diseases. Read More

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http://dx.doi.org/10.1186/s13099-018-0281-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337822PMC
January 2019
6 Reads

Genome divergence and increased virulence of outbreak associated subspecies .

Gut Pathog 2018 24;10:53. Epub 2018 Dec 24.

1Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD USA.

serotype is primarily a poultry adapted serotype of Salmonella that can also colonize other hosts and cause human disease. In this study, we compared the genomes of outbreak associated non-outbreak causing ser. strains from diverse hosts and geographical regions. Read More

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http://dx.doi.org/10.1186/s13099-018-0279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304783PMC
December 2018
1 Read

Antibiotic resistance, the 3As and the road ahead.

Gut Pathog 2018 22;10:52. Epub 2018 Dec 22.

2Robert-Koch-Institute, Nordufer 20, 13353 Berlin, Germany.

Antibiotic resistance is by far one of the most important health threats of our time. Only a global concerted effort of several disciplines based on the One-Health concept will help in slowing down this process and potentially mitigate the ruin of healthcare we have come to enjoy. In this review, we attempt to summarize the most basic and important topics that serve as good information tools to create . Read More

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http://dx.doi.org/10.1186/s13099-018-0280-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303944PMC
December 2018

A decrease in anaerobic bacteria promotes overgrowth while β-glucan treatment restores the gut microbiota and attenuates colitis.

Gut Pathog 2018 3;10:50. Epub 2018 Dec 3.

1U995/Team2, INSERM, 59000 Lille, France.

Background: The intestinal microbiota plays a crucial role in the maintenance of gut homeostasis. Changes in crosstalk between the intestinal epithelial cells, immune cells and the microbiota are critically involved in the development of inflammatory bowel disease. In the experimental mouse model, the development of colitis induced by dextran sulfate sodium (DSS) promotes overgrowth of the opportunistic yeast pathogen . Read More

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http://dx.doi.org/10.1186/s13099-018-0277-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276212PMC
December 2018
16 Reads

Development of multiplex PCR and multi-color fluorescent in situ hybridization (-FISH) coupled protocol for detection and imaging of multi-pathogens involved in inflammatory bowel disease.

Gut Pathog 2018 5;10:51. Epub 2018 Dec 5.

Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, 4110 Libra Drive, Orlando, FL USA.

Background: Several pathogens have been debated to play a role in inflammatory bowel disease (IBD) including Crohn's disease (CD). None of these pathogens have been investigated together in same clinical samples. We developed a multiplex PCR and multi-color fluorescent in situ hybridization (-FISH) protocols for simultaneous detection of CD-associated pathogens including subspecies (MAP), , and adherent-invasive strain LF82. Read More

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http://dx.doi.org/10.1186/s13099-018-0278-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280354PMC
December 2018
1 Read

Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.

Gut Pathog 2018 29;10:49. Epub 2018 Nov 29.

7Physics Department, Boston University, Boston, USA.

Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population. Read More

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http://dx.doi.org/10.1186/s13099-018-0276-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263052PMC
November 2018
6 Reads

Characterization and CRISPR-based genotyping of clinical -positive .

Gut Pathog 2018 13;10:48. Epub 2018 Nov 13.

1Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand.

Background: is a causative agent of gastroenteritis. Most of the clinical isolates carry either and/or genes which are considered as the major virulence genes of this pathogen. In this study, the clinical isolates of carrying gene (= 73) obtained from 1886 to 2012 from various countries were investigated for the urease production, haemolytic activity, and biofilm formation. Read More

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http://dx.doi.org/10.1186/s13099-018-0275-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233571PMC
November 2018
8 Reads

Genome sequence of 4303.

Gut Pathog 2018 24;10:47. Epub 2018 Oct 24.

1Institute of Bioanalysis, Medical School, University of Pécs, Szigeti út 12, 7624 Pécs, Hungary.

Background: spp. are Gram-negative intracellular pathogenic bacteria belonging to the family and can cause bacterial dysentery, a severe diarrheal disease. The pathophysiological impact of the Gram-negative bacteria is highly related to the composition and structural variability of lipopolysaccharides, the major lipoid components of the outer membrane. Read More

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http://dx.doi.org/10.1186/s13099-018-0274-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201595PMC
October 2018
1 Read

Proliferation of enterotoxigenic strain TW11681 in stools of experimentally infected human volunteers.

Gut Pathog 2018 16;10:46. Epub 2018 Oct 16.

5Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Background: As part of the effort to develop an enterotoxigenic (ETEC) human challenge model for testing new heat-stable toxin (ST)-based vaccine candidates, a controlled human infection model study based on the ST-producing ETEC strain TW11681 was undertaken. Here, we estimate stool TW11681 DNA concentration and evaluate its association with dose, clinical symptoms, and with levels of antibodies targeting the CfaB subunit of the ETEC Colonization Factor Antigen I and the mucinase YghJ. Nine volunteers ingested different doses of the strain and were subsequently followed for 9 days with daily stool specimen collection and clinical examination. Read More

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http://dx.doi.org/10.1186/s13099-018-0273-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192177PMC
October 2018
10 Reads

Purification of oocysts obtained from human stool specimens for whole genome sequencing.

Gut Pathog 2018 12;10:45. Epub 2018 Oct 12.

4Waterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA USA.

Background: is a food-borne intestinal human parasite that causes outbreaks of diarrhea. There is a need for efficient laboratory methods for strain-level characterization to assist in outbreak investigations. By using next generation sequencing, genomic sequences can be obtained and compared to identify potential genotyping markers. Read More

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http://dx.doi.org/10.1186/s13099-018-0272-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182803PMC
October 2018
16 Reads

The microbiome of Crohn's disease aphthous ulcers.

Gut Pathog 2018 10;10:44. Epub 2018 Oct 10.

1Medical School, Australian National University, Canberra, ACT 2600 Australia.

Background: Reduced intestinal microbial diversity and bacterial imbalance (dysbiosis) are seen in studies of Crohn's disease. As it is difficult to obtain biopsy samples before disease presentation, the earliest mucosal lesions in Crohn's disease, aphthous ulcers, present the best chance at assessing microbial communities at the onset of disease or a new flare. The aim of our study was to compare the microbial communities of aphthous ulcers and adjacent normal mucosa from patients with Crohn's disease with normal mucosa from controls. Read More

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http://dx.doi.org/10.1186/s13099-018-0265-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178265PMC
October 2018
21 Reads

Determination of virulence and fitness genes associated with the , and integration sites of LEE-negative food-borne Shiga toxin-producing strains.

Gut Pathog 2018 8;10:43. Epub 2018 Oct 8.

1Institute of Food Science and Biotechnology, University of Hohenheim, Garbenstr. 28, 70599 Stuttgart, Germany.

Background: In the current study, nine foodborne "Locus of Enterocyte Effacement" (LEE)-negative Shiga toxin-producing (STEC) strains were selected for whole genome sequencing and analysis for yet unknown genetic elements within the already known LEE integration sites , and . Foreign DNA ranging in size from 3.4 to 57 kbp was detected and further analyzed. Read More

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http://dx.doi.org/10.1186/s13099-018-0271-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174562PMC
October 2018
2 Reads

Complete genome sequence of BT304, isolated from the small intestine of castrated beef cattle.

Gut Pathog 2018 27;10:42. Epub 2018 Sep 27.

Department of Biology and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447 Republic of Korea.

Background: Members of the species , belonging to the family in the phylum , have been isolated from a wide variety of natural sources, such as soil, freshwater, fish gut, and clinical specimens. . is important from an industrial viewpoint, because the bacterium grows rapidly with high cell density and exhibits robustness at various growth conditions. Read More

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http://dx.doi.org/10.1186/s13099-018-0270-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161389PMC
September 2018
2 Reads

The prevalence of spp. in vegetables, fruits, and fresh produce: a systematic review and meta-analysis.

Gut Pathog 2018 27;10:41. Epub 2018 Sep 27.

2Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

There are a number of reports indicating correlation between outbreaks of campylobacteriosis and the consumption of raw vegetables. This study is a meta-analysis on the prevalence of in fresh vegetables and fruits without any location limitation, which was performed through a documented review of the available resources. Relevant literature was reviewed by trained reviewers, who examined the results for the inclusion of articles in the meta-analysis. Read More

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http://dx.doi.org/10.1186/s13099-018-0269-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158901PMC
September 2018
11 Reads

Characterization of serovars recovered from meat products legally and illegally imported into the EU reveals the presence of multiresistant and AmpC-producing isolates.

Gut Pathog 2018 22;10:40. Epub 2018 Sep 22.

1Institute of Food Quality and Food Safety, University of Veterinary Medicine Hannover Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany.

Background: Food products of animal origin brought into the EU from third countries, both legally and illegally, can harbor foodborne pathogens such as . In this study, we examined five isolates recovered either from legally imported chicken meat (n = 3) or from meat products confiscated from air travel passengers arriving in Germany (n = 2). The isolates were serotyped and further characterized by antimicrobial susceptibility testing, PCR-detection and sequencing of genes associated with antimicrobial resistances, and macrorestriction analysis. Read More

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http://dx.doi.org/10.1186/s13099-018-0268-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151051PMC
September 2018
1 Read

Antimicrobial resistance in from healthy broilers in Egypt: emergence of colistin-resistant and extended-spectrum β-lactamase-producing .

Gut Pathog 2018 19;10:39. Epub 2018 Sep 19.

Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743 Jena, Germany.

Background: Poultry remains one of the most important reservoir for zoonotic multidrug resistant pathogens. The global rise of antimicrobial resistance in Gram-negative bacteria is of reasonable concern and demands intensified surveillance.

Methods: In 2016, 576 cloacal swabs were collected from 48 broiler farms located in five governorates in northern Egypt. Read More

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http://dx.doi.org/10.1186/s13099-018-0266-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148799PMC
September 2018
4 Reads
2.070 Impact Factor

Genome characterization of bile-isolated ACCC.

Gut Pathog 2018 18;10:38. Epub 2018 Sep 18.

Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, 82144 Taiwan.

Background: has been recognized as an emerging human pathogen. However, not much is known about the mechanism of its pathogenesis and its adaptation to a special niche such as the hepatobiliary tract.

Results: In this study, we isolated the ACCC strain from human bile and performed whole genome sequencing. Read More

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http://dx.doi.org/10.1186/s13099-018-0267-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145196PMC
September 2018
1 Read

Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai.

Gut Pathog 2018 11;10:37. Epub 2018 Sep 11.

1Department of Laboratory Medicine, Huadong Hospital, Affiliated with Fudan University, Shanghai, 200040 China.

Background: Culture-based diagnostic methods cannot achieve rapid and precise diagnoses for the identification of multiple diarrhoeal pathogens (DPs). A high-throughput multiplex genetic detection system (HMGS) was adapted and evaluated for the simultaneous identification and differentiation of infectious DPs and a broad analysis of DP infection aetiology.

Results: DP-HMGS was highly sensitive and specific for DP detection compared with culture-based techniques and was similar to singleplex real-time PCR. Read More

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http://dx.doi.org/10.1186/s13099-018-0264-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134694PMC
September 2018
6 Reads

Phylogenetic characterization of norovirus strains detected from sporadic gastroenteritis in Seoul during 2014-2016.

Gut Pathog 2018 27;10:36. Epub 2018 Aug 27.

2Department of Biochemistry and Molecular Biology, Ajou University School of Medicine and Graduate School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499 Republic of Korea.

Background: Phylogenetic analysis of norovirus (NoV) is efficient for tracking NoV transmission. To determine the widespread NoV strains in Seoul, we conducted an extensive phylogenetic characterization of NoV-positives from 1659 diarrheal specimens collected in 2014-2016 for the Seoul NoV-surveillance.

Results: When the large numbers of NoV partial VP1 genome sequences were analyzed in acute gastroenteritis patients along with the phylogenetic characterization, we could identify molecular epidemiologic patterns based on the genetic characteristics of sporadic NoV strains circulating in Seoul, which could provide a detailed description of the genome-wide and community-wide NoV evolution in each genotype. Read More

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http://dx.doi.org/10.1186/s13099-018-0263-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112129PMC
August 2018
13 Reads

Virulence gene profiles and molecular genetic characteristics of diarrheagenic from a hospital in western China.

Gut Pathog 2018 17;10:35. Epub 2018 Aug 17.

1Department of Medical Genetics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan China.

Background: Diarrheagenic (DEC) is one of the most important etiological agents of diarrheal diseases. In this study we investigated the prevalence, virulence gene profiles, antimicrobial resistance, and molecular genetic characteristics of DEC at a hospital in western China.

Methods: A total of 110 clinical isolates were collected from the First Affiliated Hospital of Chengdu Medical College from 2015 to 2016. Read More

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http://dx.doi.org/10.1186/s13099-018-0262-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097206PMC
August 2018
4 Reads
2.070 Impact Factor

Cecal microbiome profile altered by , serovar Enteritidis inoculation in chicken.

Gut Pathog 2018 3;10:34. Epub 2018 Aug 3.

1College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271000 Shandong China.

Background: , serovar Enteritidis ( Enteritidis), an important zoonotic foodborne pathogen, can affect the microbiota of the chicken intestine and cause many enteric diseases, such as acute gastroenteritis. The gut microbiota contributes to the development and function of the host immune system and competes with pathogenic microbes. The interaction between Enteritidis and the host cecal microbiota is still not fully understood. Read More

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http://dx.doi.org/10.1186/s13099-018-0261-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074038PMC
August 2018
3 Reads

Rapid Isolation of intact -containing vacuoles using paramagnetic nanoparticles.

Gut Pathog 2018 31;10:33. Epub 2018 Jul 31.

1Centre for Infection Medicine, Institute of Microbiology and Epizootics, Free University of Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany.

Background: Both typhoidal and non-typhoidal infections remain a considerable cause of morbidity and mortality globally, and impose a major socio-economic burden worldwide. A key property of all pathogenic strains is the ability to invade host cells and reside within an intracellular, vacuolar compartment called the -containing vacuole (SCV). Although the SCV is involved in both immune-evasion and intracellular replication and spread within the host, information about the host:pathogen interactions at this interface are limited, in part due to the technical difficulties involved in purification of these vacuoles. Read More

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http://dx.doi.org/10.1186/s13099-018-0256-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069567PMC
July 2018
11 Reads

Occurrence of multidrug-resistant and ESBL-producing atypical enteropathogenic in China.

Gut Pathog 2018 27;10. Epub 2018 Feb 27.

1State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.

Background: Atypical enteropathogenic (aEPEC) is regarded as a globally emerging enteropathogen. aEPECs exhibit various level of resistance to a range of antibiotics, which is increasing alarmingly. The present study investigated the antimicrobial resistance of aEPEC isolates recovered from diarrheal patients, healthy carriers, animals, and raw meats. Read More

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http://dx.doi.org/10.1186/s13099-018-0234-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054294PMC
February 2018

Complete genome sequence of KLDS6.0933, a potential probiotic strain with high cholesterol removal ability.

Gut Pathog 2018 19;10:32. Epub 2018 Jul 19.

1Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin, 150030 People's Republic of China.

Background: are commensal bacteria in the mammalian gastrointestinal tract which play an important role in the production of various fermented foods. Thus, certain enterococcal strains are commonly used as probiotics to confer health benefits to human and animals. KLDS6. Read More

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http://dx.doi.org/10.1186/s13099-018-0260-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052589PMC
July 2018
2 Reads

Prevalence, resistance pattern, and molecular characterization of isolates from healthy animals and sick populations in Henan Province, China.

Gut Pathog 2018 17;10:31. Epub 2018 Jul 17.

1College of Animal Husbandry and Veterinary Science, Henan Agricultural University, No. 95 Wenhua Road, Zhengzhou, China.

Background: is one of the most prevalent pathogens and a causative agent of a variety of infections in humans and animals. A total of 640 samples were collected from healthy animals and patients from 2013 to 2014 in Henan Province, China, to investigate the prevalence and perform molecular characterization of . Antimicrobial resistance and virulence genes were determined and pulsed-field gel electrophoresis (PFGE) and cassette chromosome (SCC) typing were performed. Read More

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http://dx.doi.org/10.1186/s13099-018-0254-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048774PMC
July 2018
7 Reads
1 Citation
2.070 Impact Factor

Identification of a new alanine racemase in Enteritidis and its contribution to pathogenesis.

Gut Pathog 2018 10;10:30. Epub 2018 Jul 10.

School of Biotechnology, KIIT University, Bhubaneswar, Odisha India.

Background: Non-typhoidal (NTS) infections caused primarily by Enteritidis and Typhimurium particularly in immunocompromised hosts have accounted for a large percentage of fatalities in developed nations. Antibiotics have revolutionized the cure of enteric infections but have also led to the rapid emergence of pathogen resistance. New powerful therapeutics involving metabolic enzymes are expected to be potential targets for combating microbial infections and ensuring effective health management. Read More

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http://dx.doi.org/10.1186/s13099-018-0257-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040060PMC
July 2018
10 Reads

Identification of in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study.

Gut Pathog 2018 10;10:29. Epub 2018 Jul 10.

1UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Read More

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http://dx.doi.org/10.1186/s13099-018-0258-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040075PMC
July 2018
12 Reads

Gut colonization with vancomycin-resistant and risk for subsequent enteric infection.

Gut Pathog 2018 9;10:28. Epub 2018 Jul 9.

2Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY USA.

Background: Gut colonization with vancomycin-resistant (VRE) is associated with poor outcomes. This study evaluated the impact of VRE colonization on subsequent acquisition of enteric pathogens.

Methods: We performed a retrospective cohort study of adults admitted to an ICU from 2012 to 2017 who were screened for VRE colonization and subsequently underwent stool testing with a gastrointestinal pathogen PCR panel (GI PCR) with or without PCR testing for . Read More

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http://dx.doi.org/10.1186/s13099-018-0259-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038175PMC
July 2018
6 Reads

Emergence of G8P[6] rotavirus strains in Korean neonates.

Gut Pathog 2018 3;10:27. Epub 2018 Jul 3.

1Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, 7, Keunjaebong-gil, Hwaseong-si, Gyeonggi-do 18450 South Korea.

Background: Rotaviruses are the major causes of pediatric gastroenteritis worldwide. The genotypic distribution of rotavirus strains shows temporal and geographical fluctuations, and knowledge of the molecular epidemiology of rotaviruses is important for the development of vaccines and diagnostic reagents. We investigated VP4 and VP7 capsid genotypes of rotaviruses isolated from 211 stool specimens collected from Korean neonates in a neonatal intensive care unit from September 2017 to March 2018. Read More

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http://dx.doi.org/10.1186/s13099-018-0255-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031143PMC
July 2018
14 Reads

ESBL-plasmid carriage in enhances in vitro bacterial competition fitness and serum resistance in some strains of pandemic sequence types without overall fitness cost.

Gut Pathog 2018 15;10:24. Epub 2018 Jun 15.

1Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Str. 7-13, 14163 Berlin, Germany.

Background: Extended spectrum beta lactamase (ESBL)-producing extraintestinal pathogenic infections are of global interest because of their clinical and economic impact. The ESBL resistance genes disseminate through plasmids, and are found in successful global lineages such as ST131 and ST648. The carriage of plasmids has been suggested to result in a fitness burden, but recently it was shown that ESBL-plasmids enhanced virulence in pandemic ST131 and ST648 lineages without affecting their fitness. Read More

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http://dx.doi.org/10.1186/s13099-018-0243-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003029PMC
June 2018
3 Reads
2.070 Impact Factor

-Acetyl-glucosamine influences the biofilm formation of .

Gut Pathog 2018 22;10:26. Epub 2018 Jun 22.

1Groupe de Recherche sur les Maladies Infectieuses en Production Animale, Centre de Recherche en Infectiologie Porcine et Avicole, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC J2S 2M2 Canada.

Background: The intestinal mucous layer is a physical barrier that limits the contact between bacteria and host epithelial cells. There is growing evidence that microbiota-produced metabolites can also be specifically sensed by gut pathogens as signals to induce or repress virulence genes. Many , including adherent and invasive (AIEC) strains, can form biofilm. Read More

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http://dx.doi.org/10.1186/s13099-018-0252-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013987PMC
June 2018
1 Read

Tigecycline application in a 3-month-old infant with multiple drug resistant : a case report.

Gut Pathog 2018 22;10:25. Epub 2018 Jun 22.

Department of Neonatal Ward, Peking University First Hospital, No. 1, Xi Anmen Street, Xicheng District, Beijing, 100034 China.

Background: Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.

Case Presentation: The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant . Read More

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http://dx.doi.org/10.1186/s13099-018-0253-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014034PMC
June 2018
1 Read

High carriage of adherent invasive in wildlife and healthy individuals.

Gut Pathog 2018 14;10:23. Epub 2018 Jun 14.

Lille Inflammation Research International Center, UMR 995 Inserm, Lille University, CHRU Lille, Lille, France.

Background: Adherent invasive (AIEC) are suspected to be involved in the pathogenesis of inflammatory bowel diseases. Since AIEC was first described in 1999, despite important progress on its genomic and immune characterizations, some crucial questions remain unanswered, such as whether there exists a natural reservoir, or whether there is asymptomatic carriage. The ECOR collection, including strains isolated mainly from the gut of healthy humans and animals, constitutes an ideal tool to investigate AIEC prevalence in healthy condition. Read More

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http://dx.doi.org/10.1186/s13099-018-0248-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001069PMC
June 2018
2 Reads

Takayasu's arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17.

Gut Pathog 2018 12;10:22. Epub 2018 Jun 12.

2Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Takayasu's arteritis (TA) is a large-vessel vasculitis pathologically characterized by granulomatous necrotizing vasculitis with giant cells. Although the cause of TA is still unclear, genetic factors as well as immunological abnormalities, particularly the overactivation of Th1 and Th-17, are considered to play important roles in the pathogenesis of this disease. Eosinophilic gastroenteritis (EGE) is a type of refractory inflammation in which numerous eosinophils infiltrate the inflammatory area. Read More

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http://dx.doi.org/10.1186/s13099-018-0251-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996549PMC
June 2018
19 Reads

Key lime () inhibits the growth of triple drug resistant .

Gut Pathog 2018 21;10:16. Epub 2018 May 21.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Chonnam National University Medical School, 42, Jaebongro, Dong-ku Gwangju, 501-757 South Korea.

Background: Eradication rate for () has decreased due to antibiotic resistance. Therefore, new strategies are needed to enhance eradication, especially for with high antibiotic resistance. The objective of this study was to evaluate anti- activities of constituents from key lime () and their possible inhibitory effects on urease activity of

Methods: strain ATCC 43526 and triple drug resistant (TDR) strains were used in this study. Read More

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http://dx.doi.org/10.1186/s13099-018-0244-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961513PMC
May 2018
19 Reads

The role of probiotics, prebiotics and synbiotics in animal nutrition.

Gut Pathog 2018 6;10:21. Epub 2018 Jun 6.

Department of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology, ul. Wólczańska 171/173, 90-924 Lodz, Poland.

Along with the intensive development of methods of livestock breeding, breeders' expectations are growing concerning feed additives that would guarantee such results as accelerating growth rate, protection of health from pathogenic infections and improvement of other production parameters such as: absorption of feed and quality of meat, milk, eggs. The main reason for their application would be a strive to achieve some beneficial effects comparable to those of antibiotic-based growth stimulators, banned on 01 January 2006. High hopes are being associated with the use of probiotics, prebiotics and synbiotics. Read More

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http://dx.doi.org/10.1186/s13099-018-0250-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989473PMC
June 2018
4 Reads

Characterization of a novel multidrug resistance plasmid pSGB23 isolated from subspecies enterica serovar Saintpaul.

Gut Pathog 2018 4;10:20. Epub 2018 Jun 4.

2Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, 637551 Singapore.

Background: subspecies enterica serovar Saintpaul (. Saintpaul) is an important gut pathogen which causes salmonellosis worldwide. Although intestinal salmonellosis is usually self-limiting, it can be life-threatening in children, the elderlies and immunocompromised patients. Read More

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http://dx.doi.org/10.1186/s13099-018-0249-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985583PMC
June 2018
10 Reads

Impact of the introduction of a nucleic acid amplification test for diagnosis on stool rejection policies.

Gut Pathog 2018 30;10:19. Epub 2018 May 30.

1Laboratoire de Bactériologie, C.H.U. de Bordeaux, Groupe Hospitalier Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux Cedex, France.

Background: The change from non-molecular to nucleic acid amplification tests (NAATs) is known to increase the detection of infection (CDI); however, the impact on stool rejection policies in clinical laboratories is unclear. The current guidelines have reinforced the importance of respecting strict conditions for performing tests on stool samples for CDI diagnosis. The purpose of this study was to estimate whether the implementation of molecular tests has resulted in changes in stool rejection policies between clinical laboratories that introduced NAATs and those that did not. Read More

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http://dx.doi.org/10.1186/s13099-018-0245-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975266PMC
May 2018
1 Read

Antimicrobial resistant isolated from non-diarrheal child stool sample in Battambang, Cambodia.

Gut Pathog 2018 30;10:18. Epub 2018 May 30.

1Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400 Thailand.

() is associated with human gastroenteritis; however, was isolated and confirmed by phenotypic and genotypic identification from a non-diarrheal child stool sample in Cambodia. Antimicrobial susceptibility testing demonstrated that this isolate had a high minimal inhibitory concentration against macrolides and quinolones, which are first-line antibiotic treatment choices for infections. Consequently, macrolides and quinolones were likewise expected to be ineffective against -like organisms such as . Read More

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https://gutpathogens.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13099-018-0246-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975586PMC
May 2018
11 Reads

Genome analyses of carrying ST 315 isolate from sewage water of one of the Indian hospitals.

Gut Pathog 2018 24;10:17. Epub 2018 May 24.

Medical Microbiology and Molecular Biology, Laboratory Interdisciplinary, Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002 India.

Background: Emergence of carbapenem resistant pathovars and their environmental dissemination are alarming problems. isolated from sewage water of hospital setting conferred a high resistance towards β-lactams, particularly towards carbapenem. This prompted us to perform whole genome sequence analysis to investigate the antimicrobial determinants, pathogenicity status and mobile genetic elements associated with resistance genes. Read More

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https://gutpathogens.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13099-018-0247-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968484PMC
May 2018
3 Reads

A hybrid reference-guided de novo assembly approach for generating mitochondrion genomes.

Gut Pathog 2018 10;10:15. Epub 2018 Apr 10.

Office of Applied Research and Safety Assessment (OARSA), Center for Food Safety and Applied Nutrition (CFSAN), US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 2070 USA.

is a coccidian parasite associated with large and complex foodborne outbreaks worldwide. Linking samples from cyclosporiasis patients during foodborne outbreaks with suspected contaminated food sources, using conventional epidemiological methods, has been a persistent challenge. To address this issue, development of new methods based on potential genomically-derived markers for strain-level identification has been a priority for the food safety research community. Read More

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http://dx.doi.org/10.1186/s13099-018-0242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891936PMC
April 2018
2 Reads

The prevalence of infection and other risk factors among Mongolian dyspeptic patients who have a high incidence and mortality rate of gastric cancer.

Gut Pathog 2018 4;10:14. Epub 2018 Apr 4.

2Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593 Japan.

Background: Mongolia has not only the second highest incidence rate but also the highest mortality rate for gastric cancer globally. In addition to gastric cancer, ulcerative disease complications are also life threatening; thus, investigating infection and other risk factors is essential.

Results: infection was high in tested dyspeptic patients from all parts of Mongolia, with an overall infection rate of 80. Read More

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http://dx.doi.org/10.1186/s13099-018-0240-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883366PMC
April 2018
12 Reads

Infectious bursal disease virus inoculation infection modifies -host interaction in broilers.

Gut Pathog 2018 30;10:13. Epub 2018 Mar 30.

1Clinic for Poultry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.

Background: is considered as a chicken commensal. The gut microbiota and the immune status of the host may affect its colonization. Infectious bursal disease virus (IBDV) is an immunosuppressive virus of chickens, which allows secondary pathogens to invade or exacerbates their pathogenesis. Read More

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https://gutpathogens.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13099-018-0241-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877392PMC
March 2018
8 Reads

The impact of on the gut microbial community of .

Gut Pathog 2018 20;10:12. Epub 2018 Mar 20.

Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697 USA.

Background: The root extract of has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and , shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the family, , has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Although, has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain. Using as our model system, the purpose of this work was to examine whether the anti-aging properties of are due to its impact on the microbial composition of the fly gut. Read More

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http://dx.doi.org/10.1186/s13099-018-0239-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861609PMC
March 2018
5 Reads

Genomic characterization of malonate positive serotype O:2, sequence type 64 strains, isolated from clinical, food, and environment samples.

Gut Pathog 2018 10;10:11. Epub 2018 Mar 10.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708 USA.

Background: Malonate utilization, an important differential trait, well recognized as being possessed by six of the seven species is thought to be largely absent in (Csak). The current study provides experimental evidence that confirms the presence of a malonate utilization operon in 24 strains of sequence type (ST) 64, obtained from Europe, Middle East, China, and USA; it offers explanations regarding the genomic diversity and phylogenetic relatedness among these strains, and that of other strains.

Results: In this study, the presence of a malonate utilization operon in these strains was initially identified by DNA microarray analysis (MA) out of a pool of 347 strains obtained from various surveillance studies involving clinical, spices, milk powder sources and powdered infant formula production facilities in Ireland and Germany, and dried dairy powder manufacturing facilities in the USA. Read More

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https://gutpathogens.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13099-018-0238-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845375PMC
March 2018
14 Reads

Chlortetracycline and florfenicol induce expression of genes associated with pathogenicity in multidrug-resistant serovar Typhimurium.

Gut Pathog 2018 5;10:10. Epub 2018 Mar 5.

1Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, IA USA.

Background: Multidrug-resistant (MDR) serovar Typhimurium (. Typhimurium) is a serious public health threat as infections caused by these strains are more difficult and expensive to treat. Livestock serve as a reservoir for MDR , and the antibiotics chlortetracycline and florfenicol are frequently administrated to food-producing animals to treat and prevent various diseases. Read More

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http://dx.doi.org/10.1186/s13099-018-0236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836442PMC
March 2018
3 Reads

Towards ending viral hepatitis as a public health threat: translating new momentum into concrete results in South-East Asia.

Gut Pathog 2018 5;10. Epub 2018 Mar 5.

World Health Organization, Regional Office for South-East Asia, World Health House, Indraprastha Estate, Mahatma Gandhi Marg, New Delhi, 110 002 India.

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http://dx.doi.org/10.1186/s13099-018-0237-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836424PMC
March 2018
7 Reads

Molecular epidemiology of genogroup II norovirus infections in acute gastroenteritis patients during 2014-2016 in Pudong New Area, Shanghai, China.

Gut Pathog 2018 23;10. Epub 2018 Feb 23.

1School of Public Health, Fudan University, Shanghai, 200032 China.

Background: Norovirus (NoV), a member of the Caliciviridae, is now recognized as the leading cause of acute gastroenteritis (AGE) worldwide. Globally, the GII.4 Sydney_2012 variant has predominated in NoV-related AGE since 2012, although the novel variant GII. Read More

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http://dx.doi.org/10.1186/s13099-018-0233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824483PMC
February 2018
3 Reads

Molecular detection of human enteric viruses circulating among children with acute gastroenteritis in Valencia, Venezuela, before rotavirus vaccine implementation.

Gut Pathog 2018 22;10. Epub 2018 Feb 22.

1Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas (IVIC), Apdo. 21827, Caracas, 1020 Venezuela.

Background: The role of rotavirus as main etiologic agent of diarrhea has been well documented worldwide, including in Venezuela. However, information about the prevalence of gastrointestinal viruses such as calicivirus, adenovirus and astrovirus is limited and the contribution of other agents as Aichi virus and klassevirus is largely unknown. To explore the etiological spectrum of diarrhea associated with agents other than rotaviruses, 227 stool samples from children under 5 years old with acute gastroenteritis, collected in Valencia (Venezuela) from 2001 to 2005, and previously tested as rotavirus-negative, were analyzed for caliciviruses, adenoviruses, astroviruses, Aichi viruses, klasseviruses, picobirnaviruses and enteroviruses by specific RT-PCRs. Read More

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http://dx.doi.org/10.1186/s13099-018-0232-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822563PMC
February 2018
1 Read