16,910 results match your criteria Gut[Journal]


Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: a diagnostic accuracy and cost-effectiveness study.

Gut 2018 Dec 11. Epub 2018 Dec 11.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.

Objective: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services.

Design: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). Read More

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December 2018

Microbiota and cancer immunotherapy: in search of microbial signals.

Gut 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine, University of Florida, Gainesville, Florida, USA.

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December 2018

Performance of colorectal cancer screening in the European Union Member States: data from the second European screening report.

Gut 2018 Dec 10. Epub 2018 Dec 10.

SSD Epidemiologia e screening - CPO, University Hospital 'Città della Salute e della Scienza', Turin, Italy.

Objective: To present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs).

Design: Cross-sectional study. We analysed key performance indicators-participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for adenomas and CRC-based on the aggregated quantitative data collected for the second EU screening report. Read More

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December 2018
14.660 Impact Factor

Older patients with IBD might have higher risk of Parkinson's disease.

Gut 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.

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December 2018

Role of endoscopy in chronic diarrhoea when functional bowel disease is suspected.

Gut 2018 Dec 3. Epub 2018 Dec 3.

Imperial College London, London, UK.

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December 2018
2 Reads

Fine needle aspirates comprehensively sample intrahepatic immunity.

Gut 2018 Nov 28. Epub 2018 Nov 28.

Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.

Objective: In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated if liver fine needle aspirates (FNAs) could comprehensively sample the local immune landscape in parallel with viable hepatocytes.

Design: Matched blood, liver biopsy and FNAs from 28 patients with HBV and 15 without viral infection were analysed using 16-colour multiparameter flow cytometry. Read More

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November 2018
5 Reads

Alcoholic and non-alcoholic fatty liver disease and associations with coronary artery calcification: evidence from the Kangbuk Samsung Health Study.

Gut 2018 Nov 24. Epub 2018 Nov 24.

Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK.

Objective: Recent evidence suggests that alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD) may differentially affect risk of cardiovascular mortality. To investigate whether early liver disease due to AFLD or NAFLD have similar or dissimilar effects on risk of early coronary artery atherosclerosis, we have investigated the associations between AFLD and NAFLD and coronary artery calcium (CAC).

Design: A cross-sectional study was performed in 105 328 Korean adults who attended a health check-up programme. Read More

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November 2018
4 Reads

Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer.

Gut 2018 Nov 24. Epub 2018 Nov 24.

State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.

Objectives: Bacteriome and virome alterations are associated with colorectal cancer (CRC). Nevertheless, the gut fungal microbiota in CRC remains largely unexplored. We aimed to characterise enteric mycobiome in CRC. Read More

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November 2018
4 Reads

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Gut 2018 Nov 24. Epub 2018 Nov 24.

Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.

Objectives: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human.

Design: Using Ca imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ activation evoked by ATP in jejunal tissue. Read More

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November 2018
6 Reads

Animal protein intake and hepatic steatosis in the elderly: authors' response.

Gut 2018 Nov 21. Epub 2018 Nov 21.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

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November 2018
1 Read

Unusual endoscopic treatment of recurrent cough and pneumonia.

Gut 2018 Nov 21. Epub 2018 Nov 21.

Department of Medicine II, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.

CLINICAL PRESENTATION: A 51-year-old male patient presented to our emergency department with fever, aggravating coughing and orthopnoea. Clinical evaluation revealed pneumonia in the right lower lobe of the lung and due to typical radiological hallmarks, aspiration pneumonia was suspected. During the last months, he had suffered from several pneumonias. Read More

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November 2018
2 Reads

Iron-containing micronutrient powders modify the effect of oral antibiotics on the infant gut microbiome and increase post-antibiotic diarrhoea risk: a controlled study in Kenya.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Objective: Many African infants receiving iron fortificants also receive antibiotics. Antibiotic efficacy against enteropathogens may be modified by high colonic iron concentrations. In this study, we evaluated the effect of antibiotics on the infant gut microbiome and diarrhoea when given with or without iron-containing micronutrient powders (MNPs). Read More

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November 2018
2 Reads

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Department of Medicine, University of California San Diego, La Jolla, California, USA.

Objective: Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine the mechanism that underlies REG3G suppression during experimental alcoholic liver disease.

Design: Interleukin 22 (IL-22) regulates expression of REG3G. Read More

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November 2018
8 Reads

Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Objective: To evaluate the association between statin use and risk of biliary tract cancers (BTC).

Design: This is a nested case-control study conducted in the UK Clinical Practice Research Datalink. We included cases diagnosed with incident primary BTCs, including cancers of the gall bladder, bile duct (ie, both intrahepatic and extrahepatic cholangiocarcinoma), ampulla of Vater and mixed type, between 1990 and 2017. Read More

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November 2018
1 Read

Authors reply: treatment strategy for necrotising pancreatitis.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Center for Interventional Endoscopy, Florida Hospital, Orlando, Florida, USA.

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November 2018
3 Reads

NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study.

Gut 2018 Nov 17. Epub 2018 Nov 17.

Clinical Haematology, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.

Objectives: Primary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from innate-like lymphocytes, which may carry NK receptors (NKRs).

Design: NKRs expression was compared by flow cytometry in intraepithelial lymphocytes (IEL) from CD, type I or type II refractory CD (RCD). Read More

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November 2018
7 Reads

Inhibition of monoacylglycerol lipase for the treatment of liver disease: tempting but still playing with fire.

Gut 2018 Nov 15. Epub 2018 Nov 15.

Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

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November 2018

An Asian consensus on standards of diagnostic upper endoscopy for neoplasia.

Gut 2018 Nov 12. Epub 2018 Nov 12.

Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.

Background: This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers.

Method: The Delphi method was used to develop consensus statements through identification of clinical questions on diagnostic endoscopy. Three consensus meetings were conducted to consolidate the statements and voting. Read More

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November 2018
11 Reads

Resilience of human gut microbial communities for the long stay with multiple dietary shifts.

Gut 2018 Nov 12. Epub 2018 Nov 12.

Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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November 2018
9 Reads
14.660 Impact Factor

Stopping 5-aminosalicylates in patients with ulcerative colitis starting biologic therapy does not increase the risk of adverse clinical outcomes: analysis of two nationwide population-based cohorts.

Gut 2018 Nov 12. Epub 2018 Nov 12.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.

Objective: The benefit of continuing 5-aminosalicylate (5-ASA) in patients with ulcerative colitis (UC) who initiate anti-tumour necrosis factor-alpha (anti-TNF) biologics is unknown. We aimed to compare clinical outcomes in patients with UC already on 5-ASA who started anti-TNF and then either stopped or continued 5-ASA.

Design: Our primary outcome was any adverse clinical event defined as a composite of new corticosteroid use, UC-related hospitalisation or surgery. Read More

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November 2018
3 Reads

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.

Gut 2018 Nov 10. Epub 2018 Nov 10.

Cancer Research Center of Lyon, UMR INSERM 1052, Lyon, France.

Objective: Pancreatic cancer is associated with an abundant stromal reaction leading to immune escape and tumour growth. This massive stroma drives the immune escape in the tumour. We aimed to study the impact of βig-h3 stromal protein in the modulation of the antitumoural immune response in pancreatic cancer. Read More

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November 2018
5 Reads

Identifying optimal candidates for early TIPS among patients with cirrhosis and acute variceal bleeding: a multicentre observational study.

Gut 2018 Nov 10. Epub 2018 Nov 10.

Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Objectives: Early placement of transjugular intrahepatic portosystemic shunt (TIPS) has been shown to improve survival in high-risk patients (Child-Pugh B plus active bleeding at endoscopy or Child-Pugh C 10-13) with cirrhosis and acute variceal bleeding (AVB). However, early TIPS criteria may overestimate the mortality risk in a significant proportion of patients, and the survival benefit conferred by early TIPS in such patients has been questioned. Alternative criteria have been proposed to refine the criteria used to identify candidates for early TIPS. Read More

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November 2018
6 Reads

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine.

Gut 2018 Nov 5. Epub 2018 Nov 5.

Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Cancer Division, Sydney, New South Wales, Australia.

Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly solid tumours. This is due to a generally late-stage diagnosis of a primarily treatment-refractory disease. Several large-scale sequencing and mass spectrometry approaches have identified key drivers of this disease and in doing so highlighted the vast heterogeneity of lower frequency mutations that make clinical trials of targeted agents in unselected patients increasingly futile. Read More

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November 2018
1 Read

Non-superiority of lumen-apposing metal stents: Is the evidence conclusive?

Gut 2018 Nov 2. Epub 2018 Nov 2.

Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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November 2018
1 Read

Participation and yield of a population-based colorectal cancer screening programme in China.

Gut 2018 Oct 30. Epub 2018 Oct 30.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: Colorectal cancer (CRC) screening has been widely implemented in many countries. However, evidence on participation and diagnostic yield of population-based CRC screening in China is sparse.

Design: The analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1 381 561 eligible participants aged 40-69 years from 16 provinces in China from 2012 to 2015. Read More

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October 2018
5 Reads

Chronic diarrhoea: the indications for lower GI endoscopy when functional bowel disease is suspected.

Gut 2018 Oct 30. Epub 2018 Oct 30.

Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, Bedfordshire, UK.

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October 2018
2 Reads

Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice.

Gut 2018 Oct 30. Epub 2018 Oct 30.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Objective: The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a prognostic indicator of CVD incident in patients and raised the interest of intervention targeting gut microbiota. Here we develop a clinically applicable method called oral carnitine challenge test (OCCT) for TMAO-related therapeutic drug efforts assessment and personalising dietary guidance. Read More

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October 2018
5 Reads
14.660 Impact Factor

Animal protein intake and hepatic steatosis in the elderly.

Gut 2018 Oct 30. Epub 2018 Oct 30.

Department of Paediatrics, University of Cambridge, Cambridge, UK.

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October 2018
1 Read

promotes colorectal tumorigenesis through the action of cytolethal distending toxin.

Gut 2018 Oct 30. Epub 2018 Oct 30.

Department of Medicine, University of Florida, Gainesville, Florida, USA.

Objective: produces a genotoxin, cytolethal distending toxin (CDT), which has DNAse activity and causes DNA double-strand breaks. Although infection has been shown to promote intestinal inflammation, the impact of this bacterium on carcinogenesis has never been examined.

Design: Germ-free (GF) mice, fed with 1% dextran sulfate sodium, were used to test tumorigenesis potential of CDT-producing . Read More

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October 2018
4 Reads

Antibiotic and acid-suppression medications during early childhood are associated with obesity.

Gut 2019 Jan 30;68(1):62-69. Epub 2018 Oct 30.

Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Objective: Gut microbiota alterations are associated with obesity. Early exposure to medications, including acid suppressants and antibiotics, can alter gut biota and may increase the likelihood of developing obesity. We investigated the association of antibiotic, histamine-2 receptor antagonist (H2RA) and proton pump inhibitor (PPI) prescriptions during early childhood with a diagnosis of obesity. Read More

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January 2019
1 Read

Lumen-apposing metal stent acted as an interim role in walled-off necrosis drainage.

Gut 2018 Oct 27. Epub 2018 Oct 27.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.

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October 2018
5 Reads

Devil hepatitis D: an orphan disease or largely underdiagnosed?

Gut 2018 Oct 27. Epub 2018 Oct 27.

Divisions of Gastroenterology and Hepatology of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.

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October 2018
4 Reads

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth.

Gut 2018 Oct 20. Epub 2018 Oct 20.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background And Aims: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumour with a poor prognosis using current treatments. Targeted therapies may offer a new avenue for more effective strategies. Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase with contradictory roles in different tumours that is uncharacterised in PDAC. Read More

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October 2018
6 Reads

Role of BMP-9 in human liver disease.

Gut 2018 Oct 20. Epub 2018 Oct 20.

Storr Liver Centre, The Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, New South Wales, Australia.

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October 2018

Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression.

Gut 2018 Oct 18. Epub 2018 Oct 18.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed the impact of depression and antidepressant therapies on the development of IBD.

Design: The Health Improvement Network (THIN) was used to identify a cohort of patients with new-onset depression from 1986 to 2012. Read More

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October 2018
5 Reads

Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.

Gut 2018 Oct 18. Epub 2018 Oct 18.

Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

Objective: Despite advances in the identification of epigenetic alterations in pancreatic cancer, their biological roles in the pathobiology of this dismal neoplasm remain elusive. Here, we aimed to characterise the functional significance of histone lysine methyltransferases (KMTs) and demethylases (KDMs) in pancreatic tumourigenesis.

Design: DNA methylation sequencing and gene expression microarrays were employed to investigate CpG methylation and expression patterns of KMTs and KDMs in pancreatic cancer tissues versus normal tissues. Read More

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October 2018
2 Reads

SWI/SNF component restrains pancreatic neoplasia formation.

Gut 2018 Oct 12. Epub 2018 Oct 12.

Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: is commonly mutated in pancreatic ductal adenocarcinoma (PDAC), but the functional effects of mutations in the pancreas are unclear. Understanding the molecular mechanisms that drive PDAC formation may lead to novel therapies.

Design: Concurrent conditional deletion and activation mutations were modelled in mice. Read More

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October 2018
8 Reads

Towards optimal pancreatic cyst fluid management: the need for standardisation.

Gut 2018 Oct 9. Epub 2018 Oct 9.

Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.

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October 2018

Quantification of HBV core antibodies may help revisit infectious occult hepatitis B virus.

Gut 2018 Oct 9. Epub 2018 Oct 9.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.

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October 2018
1 Read

Rare cause of rectal stenosis in a patient with long-term use of Infliximab and Mercaptopurine for ulcerative colitis.

Gut 2018 Oct 9. Epub 2018 Oct 9.

Department of Gastroenterology, AP-HP Hôpital Saint Louis, Paris, France.

Question: A 58-year-old, non-smoker male patient with no family history was followed up since 2002 for ulcerative colitis (UC) located in the rectosigmoid. He was initially treated by salicylates alone until November 2008. Mercaptopurine was started in August 2009 for steroid dependence with primary failure despite adequate 6 thioguanine nucleotides (6 TGN) level. Read More

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October 2018
2 Reads
14.660 Impact Factor

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.

Gut 2018 Oct 9. Epub 2018 Oct 9.

INSERM-UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.

Objective: Sustained inflammation originating from macrophages is a driving force of fibrosis progression and resolution. Monoacylglycerol lipase (MAGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. It is a proinflammatory enzyme that metabolises 2-arachidonoylglycerol, an endocannabinoid receptor ligand, into arachidonic acid. Read More

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October 2018
9 Reads
14.660 Impact Factor

Tight junction proteins in gastrointestinal and liver disease.

Gut 2018 Oct 8. Epub 2018 Oct 8.

Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.

Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the gut and the liver. Furthermore, TJ proteins can also be expressed outside TJs where they play important functional roles in signalling, trafficking and regulation of gene expression. Read More

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October 2018
1 Read