16,910 results match your criteria Gut[Journal]
Gut 2018 Dec 11. Epub 2018 Dec 11.
Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.
Objective: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services.
Design: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). Read More
Gut 2018 Dec 8. Epub 2018 Dec 8.
Department of Medicine, University of Florida, Gainesville, Florida, USA.
Gut 2018 Dec 10. Epub 2018 Dec 10.
SSD Epidemiologia e screening - CPO, University Hospital 'Città della Salute e della Scienza', Turin, Italy.
Objective: To present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs).
Design: Cross-sectional study. We analysed key performance indicators-participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for adenomas and CRC-based on the aggregated quantitative data collected for the second EU screening report. Read More
Gut 2018 Dec 7. Epub 2018 Dec 7.
Gut 2018 Dec 5. Epub 2018 Dec 5.
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Gut 2018 Dec 5. Epub 2018 Dec 5.
Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.
Gut 2018 Dec 3. Epub 2018 Dec 3.
III Medizinische Klinik, Klinikum Augsburg, Augsburg, Germany.
Gut 2018 Dec 3. Epub 2018 Dec 3.
Imperial College London, London, UK.
Gut 2018 Nov 28. Epub 2018 Nov 28.
Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Objective: In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated if liver fine needle aspirates (FNAs) could comprehensively sample the local immune landscape in parallel with viable hepatocytes.
Design: Matched blood, liver biopsy and FNAs from 28 patients with HBV and 15 without viral infection were analysed using 16-colour multiparameter flow cytometry. Read More
Gut 2018 Nov 24. Epub 2018 Nov 24.
Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK.
Objective: Recent evidence suggests that alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD) may differentially affect risk of cardiovascular mortality. To investigate whether early liver disease due to AFLD or NAFLD have similar or dissimilar effects on risk of early coronary artery atherosclerosis, we have investigated the associations between AFLD and NAFLD and coronary artery calcium (CAC).
Design: A cross-sectional study was performed in 105 328 Korean adults who attended a health check-up programme. Read More
Gut 2018 Nov 24. Epub 2018 Nov 24.
State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong.
Objectives: Bacteriome and virome alterations are associated with colorectal cancer (CRC). Nevertheless, the gut fungal microbiota in CRC remains largely unexplored. We aimed to characterise enteric mycobiome in CRC. Read More
Gut 2018 Nov 24. Epub 2018 Nov 24.
Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Objectives: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human.
Design: Using Ca imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ activation evoked by ATP in jejunal tissue. Read More
Gut 2018 Nov 21. Epub 2018 Nov 21.
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Gut 2018 Nov 21. Epub 2018 Nov 21.
Department of Medicine II, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
CLINICAL PRESENTATION: A 51-year-old male patient presented to our emergency department with fever, aggravating coughing and orthopnoea. Clinical evaluation revealed pneumonia in the right lower lobe of the lung and due to typical radiological hallmarks, aspiration pneumonia was suspected. During the last months, he had suffered from several pneumonias. Read More
Gut 2018 Nov 21. Epub 2018 Nov 21.
Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium.
Gut 2018 Nov 17. Epub 2018 Nov 17.
Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Objective: Many African infants receiving iron fortificants also receive antibiotics. Antibiotic efficacy against enteropathogens may be modified by high colonic iron concentrations. In this study, we evaluated the effect of antibiotics on the infant gut microbiome and diarrhoea when given with or without iron-containing micronutrient powders (MNPs). Read More
Gut 2018 Nov 17. Epub 2018 Nov 17.
Department of Medicine, University of California San Diego, La Jolla, California, USA.
Objective: Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine the mechanism that underlies REG3G suppression during experimental alcoholic liver disease.
Design: Interleukin 22 (IL-22) regulates expression of REG3G. Read More
Gut 2018 Nov 17. Epub 2018 Nov 17.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Objective: To evaluate the association between statin use and risk of biliary tract cancers (BTC).
Design: This is a nested case-control study conducted in the UK Clinical Practice Research Datalink. We included cases diagnosed with incident primary BTCs, including cancers of the gall bladder, bile duct (ie, both intrahepatic and extrahepatic cholangiocarcinoma), ampulla of Vater and mixed type, between 1990 and 2017. Read More
Gut 2018 Nov 17. Epub 2018 Nov 17.
Center for Interventional Endoscopy, Florida Hospital, Orlando, Florida, USA.
Gut 2018 Nov 17. Epub 2018 Nov 17.
Clinical Haematology, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.
Objectives: Primary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from innate-like lymphocytes, which may carry NK receptors (NKRs).
Design: NKRs expression was compared by flow cytometry in intraepithelial lymphocytes (IEL) from CD, type I or type II refractory CD (RCD). Read More
Gut 2018 Nov 15. Epub 2018 Nov 15.
Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Gut 2018 Nov 12. Epub 2018 Nov 12.
Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo, Japan.
Background: This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers.
Method: The Delphi method was used to develop consensus statements through identification of clinical questions on diagnostic endoscopy. Three consensus meetings were conducted to consolidate the statements and voting. Read More
Gut 2018 Nov 12. Epub 2018 Nov 12.
Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Gut 2018 Nov 12. Epub 2018 Nov 12.
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Objective: The benefit of continuing 5-aminosalicylate (5-ASA) in patients with ulcerative colitis (UC) who initiate anti-tumour necrosis factor-alpha (anti-TNF) biologics is unknown. We aimed to compare clinical outcomes in patients with UC already on 5-ASA who started anti-TNF and then either stopped or continued 5-ASA.
Design: Our primary outcome was any adverse clinical event defined as a composite of new corticosteroid use, UC-related hospitalisation or surgery. Read More
Gut 2018 Nov 10. Epub 2018 Nov 10.
Cancer Research Center of Lyon, UMR INSERM 1052, Lyon, France.
Objective: Pancreatic cancer is associated with an abundant stromal reaction leading to immune escape and tumour growth. This massive stroma drives the immune escape in the tumour. We aimed to study the impact of βig-h3 stromal protein in the modulation of the antitumoural immune response in pancreatic cancer. Read More
Gut 2018 Nov 10. Epub 2018 Nov 10.
Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Objectives: Early placement of transjugular intrahepatic portosystemic shunt (TIPS) has been shown to improve survival in high-risk patients (Child-Pugh B plus active bleeding at endoscopy or Child-Pugh C 10-13) with cirrhosis and acute variceal bleeding (AVB). However, early TIPS criteria may overestimate the mortality risk in a significant proportion of patients, and the survival benefit conferred by early TIPS in such patients has been questioned. Alternative criteria have been proposed to refine the criteria used to identify candidates for early TIPS. Read More
Gut 2018 Nov 5. Epub 2018 Nov 5.
Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Cancer Division, Sydney, New South Wales, Australia.
Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly solid tumours. This is due to a generally late-stage diagnosis of a primarily treatment-refractory disease. Several large-scale sequencing and mass spectrometry approaches have identified key drivers of this disease and in doing so highlighted the vast heterogeneity of lower frequency mutations that make clinical trials of targeted agents in unselected patients increasingly futile. Read More
Gut 2018 Nov 2. Epub 2018 Nov 2.
Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Gut 2018 Oct 30. Epub 2018 Oct 30.
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: Colorectal cancer (CRC) screening has been widely implemented in many countries. However, evidence on participation and diagnostic yield of population-based CRC screening in China is sparse.
Design: The analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1 381 561 eligible participants aged 40-69 years from 16 provinces in China from 2012 to 2015. Read More
Gut 2018 Oct 30. Epub 2018 Oct 30.
Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, Bedfordshire, UK.
Gut 2018 Oct 30. Epub 2018 Oct 30.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Objective: The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a prognostic indicator of CVD incident in patients and raised the interest of intervention targeting gut microbiota. Here we develop a clinically applicable method called oral carnitine challenge test (OCCT) for TMAO-related therapeutic drug efforts assessment and personalising dietary guidance. Read More
Gut 2018 Oct 30. Epub 2018 Oct 30.
Department of Paediatrics, University of Cambridge, Cambridge, UK.
Gut 2018 Oct 30. Epub 2018 Oct 30.
Department of Medicine, University of Florida, Gainesville, Florida, USA.
Objective: produces a genotoxin, cytolethal distending toxin (CDT), which has DNAse activity and causes DNA double-strand breaks. Although infection has been shown to promote intestinal inflammation, the impact of this bacterium on carcinogenesis has never been examined.
Design: Germ-free (GF) mice, fed with 1% dextran sulfate sodium, were used to test tumorigenesis potential of CDT-producing . Read More
Gut 2019 Jan 30;68(1):62-69. Epub 2018 Oct 30.
Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Objective: Gut microbiota alterations are associated with obesity. Early exposure to medications, including acid suppressants and antibiotics, can alter gut biota and may increase the likelihood of developing obesity. We investigated the association of antibiotic, histamine-2 receptor antagonist (H2RA) and proton pump inhibitor (PPI) prescriptions during early childhood with a diagnosis of obesity. Read More
Gut 2018 Oct 27. Epub 2018 Oct 27.
Department of Gastroenterology, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.
Gut 2018 Oct 27. Epub 2018 Oct 27.
Divisions of Gastroenterology and Hepatology of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
Gut 2018 Oct 26. Epub 2018 Oct 26.
Robarts Clinical Trials, London, Ontario, Canada.
Gut 2018 Oct 20. Epub 2018 Oct 20.
Department of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden.
Gut 2018 Oct 20. Epub 2018 Oct 20.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Background And Aims: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumour with a poor prognosis using current treatments. Targeted therapies may offer a new avenue for more effective strategies. Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase with contradictory roles in different tumours that is uncharacterised in PDAC. Read More
Gut 2018 Oct 20. Epub 2018 Oct 20.
Storr Liver Centre, The Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Westmead, New South Wales, Australia.
Gut 2018 Oct 18. Epub 2018 Oct 18.
Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Objective: Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed the impact of depression and antidepressant therapies on the development of IBD.
Design: The Health Improvement Network (THIN) was used to identify a cohort of patients with new-onset depression from 1986 to 2012. Read More
Gut 2018 Oct 18. Epub 2018 Oct 18.
Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Objective: Despite advances in the identification of epigenetic alterations in pancreatic cancer, their biological roles in the pathobiology of this dismal neoplasm remain elusive. Here, we aimed to characterise the functional significance of histone lysine methyltransferases (KMTs) and demethylases (KDMs) in pancreatic tumourigenesis.
Design: DNA methylation sequencing and gene expression microarrays were employed to investigate CpG methylation and expression patterns of KMTs and KDMs in pancreatic cancer tissues versus normal tissues. Read More
Gut 2018 Oct 12. Epub 2018 Oct 12.
Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Objective: is commonly mutated in pancreatic ductal adenocarcinoma (PDAC), but the functional effects of mutations in the pancreas are unclear. Understanding the molecular mechanisms that drive PDAC formation may lead to novel therapies.
Design: Concurrent conditional deletion and activation mutations were modelled in mice. Read More
Gut 2018 Oct 9. Epub 2018 Oct 9.
Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland.
Gut 2018 Oct 9. Epub 2018 Oct 9.
Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Gut 2018 Oct 9. Epub 2018 Oct 9.
Department of Gastroenterology, AP-HP Hôpital Saint Louis, Paris, France.
Question: A 58-year-old, non-smoker male patient with no family history was followed up since 2002 for ulcerative colitis (UC) located in the rectosigmoid. He was initially treated by salicylates alone until November 2008. Mercaptopurine was started in August 2009 for steroid dependence with primary failure despite adequate 6 thioguanine nucleotides (6 TGN) level. Read More
Gut 2018 Oct 9. Epub 2018 Oct 9.
Gut 2018 Oct 9. Epub 2018 Oct 9.
INSERM-UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.
Objective: Sustained inflammation originating from macrophages is a driving force of fibrosis progression and resolution. Monoacylglycerol lipase (MAGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. It is a proinflammatory enzyme that metabolises 2-arachidonoylglycerol, an endocannabinoid receptor ligand, into arachidonic acid. Read More
Gut 2018 Oct 8. Epub 2018 Oct 8.
Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the gut and the liver. Furthermore, TJ proteins can also be expressed outside TJs where they play important functional roles in signalling, trafficking and regulation of gene expression. Read More