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    1 OF 172

    Dengue infection in the nervous system: lessons learned for Zika and Chikungunya.
    Arq Neuropsiquiatr 2017 Feb;75(2):123-126
    Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Biologia, Rio de Janeiro RJ, Brasil.
    Dengue, Zika and Chikungunya are emerging arboviruses and important causes of acute febrile disease in tropical areas. Although dengue does not represent a new condition, a geographic expansion over time has occurred with the appearance of severe neurological complications. Neglect has allowed the propagation of the vector (Aedes spp), which is also responsible for the transmission of other infections such as Zika and Chikungunya throughout the world. Read More

    Guillain-Barré syndrome and other neurological manifestations possibly related to Zika virus infection in municipalities from Bahia, Brazil, 2015.
    Epidemiol Serv Saude 2017 Jan-Mar;26(1):9-18
    Ministério da Saúde, Programa de Treinamento em Epidemiologia Aplicada aos Serviços do Sistema Único de Saúde, Brasília-DF, Brasil.
    Objective:: to describe the reported cases of Guillain-Barré Syndrome (GBS) and other neurological manifestations with a history of dengue, chikungunya or Zika virus infections, in the Metropolitan Region of Salvador and in the municipality of Feira de Santana, Brazil.

    Methods:: this is a descriptive study with data of an investigation conducted by the epidemiological surveillance from March to August 2015; to confirm the neurological manifestations, medical diagnosis records were considered, and to prior infection, clinical and laboratory criteria were used.

    Results:: 138 individuals were investigated, 57 reported infectious process up to 31 days before neurological symptoms - 30 possibly due to Zika, 13 to dengue, 8 to chikungunya and 6 were inconclusive -; GBS was the most frequent neurological condition (n=46), with predominance of male sex (n=32) and the median age was 44. Read More

    Early platelet and leukocyte decline in patients with neuroinflammatory disorders after intravenous immunoglobulins.
    Eur J Neurol 2017 Feb 22. Epub 2017 Feb 22.
    Department of Neurology, University Hospital Essen, Essen, Germany.
    Background And Purpose: Intravenous immunoglobulins (IVIGs) are a common therapy in patients with neuroinflammatory disorders, especially chronic inflammatory demyelinating polyradiculoneuropathy or Guillain-Barré syndrome. Hematological toxicities upon IVIG infusion are a known side effect and still an important subject of investigation.

    Methods: Laboratory results and data for clinical efficacy and tolerability of 62 patients with neuroinflammatory disorders treated with IVIG (0. Read More

    Peroral endoscopic myotomy for treatment of Guillain-Barre syndrome-associated achalasia: A rare case.
    World J Gastroenterol 2017 Feb;23(5):926-930
    Seung Kak Shin, Kyoung Oh Kim, Eui Joo Kim, Su Young Kim, Jung Ho Kim, Yoon Jae Kim, Jun-Won Chung, Kwang An Kwon, Dong Kyun Park, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon 21565, South Korea.
    Guillain-Barre syndrome (GBS)-associated achalasia is a very rare disease of uncertain cause. We report the case of a patient diagnosed with GBS-associated type I achalasia who was successfully treated with peroral endoscopic myotomy (POEM). A 30-year-old man who was diagnosed with GBS 3 mo before was referred to our department with dysphagia and meal-related regurgitation. Read More

    Zika Virus Disease and Associated Neurologic Complications.
    Curr Infect Dis Rep 2017 Jan;19(1)
    Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA.
    Purpose Of Review: The purpose of this article is to review what is currently known about Zika virus (ZIKV) disease and associated neurologic complications.

    Recent Findings: ZIKV is a mosquito-borne or sexually transmitted flavivirus rapidly spreading throughout the Americas. While ZIKV infection is usually asymptomatic, it may cause a non-specific illness with fever, rash, myalgia, headache, and/or non-purulent conjunctivitis. Read More

    Acute bulbar palsy plus syndrome: A rare variant of Guillain-Barre syndrome.
    J Pediatr Neurosci 2016 Oct-Dec;11(4):322-323
    Department of Pediatrics, Cantonment General Hospital, New Delhi, India.
    Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide both in adult and pediatric population. Although flaccid paralysis is the hallmark of this disease, there are some rare variants which may be easily missed unless suspected. Here, we present a very rare variant of GBS - acute bulbar palsy plus syndrome in a pediatric patient. Read More

    Zika Virus: Transmission, Detection, Control, and Prevention.
    Front Microbiol 2017 3;8:110. Epub 2017 Feb 3.
    School of Science, Monash University Selangor, Malaysia.
    Zika virus (ZIKV) is a mosquito-borne Flavivirus discovered in Uganda in the 1940s. To date, three major ZIKV outbreaks have been reported. ZIKV infections have known to be primarily asymptomatic while causing mild illness in a few cases. Read More

    Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond.
    Autoimmun Rev 2017 Feb 13. Epub 2017 Feb 13.
    Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia. Electronic address:
    Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Read More

    IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barré syndrome.
    Exp Neurol 2017 Feb 16;291:134-140. Epub 2017 Feb 16.
    Department of Neurology, Mishima Hospital, Niigata, Japan. Electronic address:
    Autoantibodies binding to peripheral nerves followed by complement deposition and membrane attack complex formation results in nerve damage in Guillain-Barré syndrome (GBS). Strategies to remove the pathogenic autoantibodies or block the complement deposition benefit most patients with GBS. Immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) is a cysteine protease which cleaves IgG antibodies into F(ab')2 and Fc fragments. Read More

    Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.
    Nat Commun 2017 Feb 17;8:14487. Epub 2017 Feb 17.
    Department of Otolaryngology-Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA.
    Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathreshold amplitude of the sound-evoked auditory nerve compound action potential. Currently, the only cellular mechanism known for HHL is loss of inner hair cell synapses (synaptopathy). Read More

    MRI findings of optic pathway involvement in Miller Fisher syndrome in 3 pediatric patients and a review of the literature.
    J Clin Neurosci 2017 Feb 10. Epub 2017 Feb 10.
    Department of Pediatrics (Neurology) and of Neurology, Yale School of Medicine, New Haven, CT, United States. Electronic address:
    Background: Miller Fisher syndrome (MFS) is a rare demyelinating condition which may have involvement of cranial nerves. There are a few case reports of optic pathway involvement in children. We describe 3 patients with optic pathway enhancement in pediatric patients with MFS. Read More

    Transmission of Zika Virus - Haiti, October 12, 2015-September 10, 2016.
    MMWR Morb Mortal Wkly Rep 2017 Feb 17;66(6):172-176. Epub 2017 Feb 17.
    Zika virus disease is caused by infection with a flavivirus with broad geographic distribution and is most frequently transmitted by the bite of an infected mosquito. The disease was first identified in the World Health Organization's Region of the Americas in 2015 and was followed by a surge in reported cases of congenital microcephaly in Brazil; Zika virus disease rapidly spread to the rest of the region and the Caribbean (1), including Haiti. Infection with the virus is associated with adverse fetal outcomes (1) and rare neurologic complications in adults. Read More

    Guillain-Barre syndrome complicating chikungunya virus infection.
    J Neurovirol 2017 Feb 13. Epub 2017 Feb 13.
    Neurosciences Center, Department of Neurology, All India Institute of Medical Sciences, Room number 707, 7th floor, New Delhi, India.
    Chikungunya virus (CHIKV) is a mosquito-borne alphavirus which presents with symptoms of fever, rash, arthralgia, and occasional neurologic disease. While outbreaks have been earlier reported from India and other parts of the world, the recent outbreak in India witnessed more than 1000 cases. Various systemic and rarely neurological complications have been reported with CHIKV. Read More

    Therapeutic Plasma Exchange in Patients with Neurologic Disorders: Review of 63 Cases.
    Indian J Hematol Blood Transfus 2017 Mar 22;33(1):97-105. Epub 2016 Feb 22.
    0000 0001 0694 8546grid.411691.aDepartment of Hematology, Mersin University Faculty of Medicine, Çiftlikköy Kampüsü, Mersin, Turkey.
    Therapeutic plasma exchange (TPE) is a procedure that reduces circulating autoantibodies of the patients. TPE is commonly used in neurological disorders where autoimmunity plays a major role. We report our experience with regard to the indications, adverse events and outcomes of plasma exchange in neurological disorders. Read More

    Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance.
    J Autoimmun 2017 Feb 9. Epub 2017 Feb 9.
    LASER Europe Ltd, London, 66 Chiltern St, London W1U 4JT, United Kingdom; Department of Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK.
    Background: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization.

    Objectives: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France.

    Methods: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Read More

    [Zika fever].
    Rev Med Interne 2017 Feb 8. Epub 2017 Feb 8.
    Service de médecine interne et polyvalente, centre hospitalier de Polynésie française, avenue du Général-de-Gaulle, 98716 Pirae Tahiti, Polynésie française. Electronic address:
    Zika virus infection is an emerging arboviral disease which presented as a mild flu-like or algo-eruptive syndrome with fever, arthralgia, myalgia and a maculopapulous eruption. Severe neurological and fetal complications have recently been highlighted. Diagnosis is established by detection of viral RNA by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Read More

    Experimental Guillain-Barre syndrome induced by immunization with gangliosides: Keyhole limpet hemocyanin is required for disease triggering.
    Biochim Biophys Acta 2017 Feb 7. Epub 2017 Feb 7.
    CIQUIBIC, CONICET, Departamento de Química Biológica "Dr. Ranwel Caputto", Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address:
    An experimental model of Guillain-Barré Syndrome has been established in recent years. Rabbits develop disease upon immunization with a single dose of an emulsion containing bovine brain gangliosides, KLH and complete Freund's adjuvant. Within a period of four to ten weeks after immunization, they began to produce anti-ganglioside IgG-antibodies first, and to show clinical signs of neuropathy afterwards. Read More

    ZIKA Virus and Neuroscience: the Need for a Translational Collaboration.
    Mol Neurobiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, 2600 Ramiro Barcelos St, Santana, Porto Alegre, RS, 90035003, Brazil.
    Zika virus (ZIKV) has become a major challenge for scientists and health agencies. ZIKV's involvement with human fetal microcephaly and Guillain-Barré syndrome and its transmission through Aedes africanus and Aedes aegypti mosquitos highlighted the epidemiological and neurological risks associated to ZIKV infection. In 2013, ZIKV arrives in Brazil but the first outbreak in the country was reported in 2015. Read More

    Zika Virus Pathogenesis and Tissue Tropism.
    Cell Host Microbe 2017 Feb;21(2):134-142
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:
    Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. The recent spread of ZIKV to countries in the Western Hemisphere is associated with reports of microcephaly, congenital malformations, and Guillain-Barré syndrome. This has resulted in ZIKV being declared a public health emergency and has greatly accelerated the pace of ZIKV research and discovery. Read More

    Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas.
    PLoS Negl Trop Dis 2017 Feb 9;11(2):e0005135. Epub 2017 Feb 9.
    Department of Biology, Stanford University, Stanford, California, United States of America.
    Since Zika virus (ZIKV) was detected in Brazil in 2015, it has spread explosively across the Americas and has been linked to increased incidence of microcephaly and Guillain-Barré syndrome (GBS). In one year, it has infected over 500,000 people (suspected and confirmed cases) in 40 countries and territories in the Americas. Along with recent epidemics of dengue (DENV) and chikungunya virus (CHIKV), which are also transmitted by Aedes aegypti and Ae. Read More

    Diabetes mellitus may affect short-term outcome of Guillain-Barré syndrome.
    J Peripher Nerv Syst 2017 Feb 8. Epub 2017 Feb 8.
    Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
    We sought to determine influence of diabetes mellitus on GBS course and short-term prognosis. Among the 257 GBS patients included in this retrospective study, diabetes mellitus was present in 17%. The degree of disability at admission and on discharge was assessed according to the GBS Disability Scale (mild disability = 0-3, severe disability = 4-6). Read More

    Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador.
    Front Microbiol 2017 24;8:42. Epub 2017 Jan 24.
    Laboratorio de Biología Molecular, Hospital Luis Vernaza Guayaquil, Ecuador.
    Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV) have been associated with clinical presentations that involve acute neurological complaints. In the current study, we identified ZIKV, CHIKV, and DENV in cerebrospinal fluid (CSF) samples from patients admitted to the Hospital Luis Vernaza (Guayaquil, Ecuador) to the Emergency Room or the Intensive Care Unit, with neurological symptoms and/or concern for acute arboviral infections. Viral RNA from one or more virus was detected in 12/16 patients. Read More

    Nelarabine-associated reversible Guillain-Barré-like syndrome or myelopathy in an adult patient with primary refractory T-lymphoblastic lymphoma.
    Curr Probl Cancer 2016 Nov 17. Epub 2016 Nov 17.
    Department of Hematology, G. Papanikolaou General Hospital, Thessaloniki, Greece.
    Nelarabine is a purine analogue used for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma mainly as a bridge to stem cell transplantation. The water-soluble prodrug of 9-beta-D-arabinofuranosyl guanine (Ara-G) is phosphorylated within leukemic cells to form ara-G triphosphate (ara-GTP), which terminates DNA chain elongation, resulting in cell death. The drug received accelerated approval by the US Food and Drug Administration (FDA) on October 2005 based on the induction of complete remissions in 2 phase II trials. Read More

    Analysis of serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barré syndrome.
    Clin Chim Acta 2017 Feb 4;468:5-9. Epub 2017 Feb 4.
    Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:
    Backgrounds: Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy. Interleukin (IL)-27 and IL-35 have been recognized as novel members of IL-12 family. We evaluated the serum and cerebral spinal fluid (CFS) concentrations of IL-27 and IL-35 in GBS and analyze their correlations with clinical characteristics. Read More

    Outcome of Guillain - Barré Syndrome in Children: A prospective cohort study in a tertiary hospital in Upper Egypt.
    Electron Physician 2016 Dec 25;8(12):3318-3324. Epub 2016 Dec 25.
    Resident, Pediatric Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
    Introduction: Guillain-Barré syndrome is the most common cause of acute flaccid paralysis in children, and defined as an acute inflammatory polyneuropathy. The objective of this study was to assess the clinico-laboratory profile, and outcome of Guillain-Barré syndrome in children at Sohag University Hospital.

    Methods: This prospective cohort observational study was conducted in 2014-2015. Read More

    Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2-49years.
    Vaccine 2017 Mar 2;35(9):1254-1258. Epub 2017 Feb 2.
    AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, United States.
    Background: Quadrivalent live attenuated influenza vaccine (Q/LAIV) was licensed in 2012 and replaced trivalent live attenuated influenza vaccine in the United States during the 2013-2014 influenza season. This study assessed the safety of Q/LAIV in children and adults aged 2-49years.

    Methods: This was a prospective observational cohort study using data collected from Kaiser Permanente Northern California. Read More

    Campylobacter jejuni and associated immune mechanisms: short-term effects and long-term implications for infants in low-income countries.
    Curr Opin Infect Dis 2017 Feb 2. Epub 2017 Feb 2.
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, United States.
    Purpose Of Review: Campylobacter jejuni is recognized as one of the most common causes of food-borne gastrointestinal illness worldwide, resulting in a self-limiting dysentery in developed countries. However, it is increasingly gaining attention due to its association with postinfectious complications such as Guillain-Barré Syndrome and recently recognized importance in early childhood diarrhea in developing countries. We hypothesize that the inflammation mediated by C. Read More

    Estimated Zika virus importations to Europe by travellers from Brazil.
    Glob Health Action 2016 Jan;9(1):31669
    e Institute of Public Health University of Heidelberg , Germany.
    Background Given the interconnectivity of Brazil with the rest of the world, Zika virus (ZIKV) infections have the potential to spread rapidly around the world via viremic travellers. The extent of spread depends on the travel volume and the endemicity in the exporting country. In the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of ZIKV from Brazil into Europe. Read More

    Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD).
    Pharmacoepidemiol Drug Saf 2017 Feb 3. Epub 2017 Feb 3.
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
    Purpose: Near real-time vaccine safety surveillance (NRTVSS) is an option for post-licensure vaccine safety assessment. NRTVSS requires timely recording of outcomes in the database used. Our main objective was to examine recording delays in the Clinical Practice Research Datalink (CPRD) for outcomes of interest for vaccine safety to inform the feasibility of NRTVSS using these data. Read More

    Zika virus induces inflammasome activation in the glial cell line U87-MG.
    Biochem Biophys Res Commun 2017 Jan 30. Epub 2017 Jan 30.
    Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy; Department of Medicine, Surgery and Public Health, University of Trieste, Trieste, Italy. Electronic address:
    In the last years, neurological complications related to Zika virus (ZIKV) infection have emerged as an important threat to public health worldwide. ZIKV infection has been associated to neurological disorders such as congenital microcephaly in newborns and Guillain-Barré syndrome, myelopathy and encephalitis in adults. ZIKV is characterized by neurotropism and neurovirulence. Read More

    Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells.
    PLoS Pathog 2017 Feb 2;13(2):e1006164. Epub 2017 Feb 2.
    Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that is causally linked to severe neonatal birth defects, including microcephaly, and is associated with Guillain-Barre syndrome in adults. Dendritic cells (DCs) are an important cell type during infection by multiple mosquito-borne flaviviruses, including dengue virus, West Nile virus, Japanese encephalitis virus, and yellow fever virus. Despite this, the interplay between ZIKV and DCs remains poorly defined. Read More

    The Use of Sugammadex in a Patient With Guillain-Barre Syndrome: A Case Report.
    A A Case Rep 2017 Feb 1. Epub 2017 Feb 1.
    From the Department of Anesthesiology and Reanimation Clinic, Turkey Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
    Sugammadex encapsulates and inactivates rocuronium and vecuronium. It is used to reverse neuromuscular blockade from these nondepolarizing agents. The safety of sugammadex in patients with neuromuscular disease has not been established. Read More

    Complications in mechanically ventilated patients of Guillain-Barre syndrome and their prognostic value.
    J Neurosci Rural Pract 2017 Jan-Mar;8(1):68-73
    Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
    Introduction: The spectrum of various complications in critically ill Guillain-Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their significance in the prognosis and mortality.

    Materials And Methods: Retrospective case record analysis of all consecutive mechanically ventilated patients of GBS in neurology Intensive Care Unit (ICU) of a tertiary care institute for 10 years was done. Read More

    Animal Models of Zika Virus Infection, Pathogenesis, and Immunity.
    J Virol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
    Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has reached global attention because of some of its unusual epidemiological and clinical features including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Read More

    Papulonodular mucinosis, Guillain-Barré syndrome and nephrotic syndrome in a patient with systemic lupus erythematosus: a case report.
    BMC Nephrol 2017 Feb 1;18(1):43. Epub 2017 Feb 1.
    Renal Division, Shanxi Medical University Second Hospital, Shanxi Kidney Disease Institute, No.382, Wuyi Road, Xinghualing Distirct, Taiyuan, Shanxi Province, China.
    Background: Awareness of the spectrum of clinical manifestations of systemic lupus erythematosus (SLE), especially uncommon changes, is essential for diagnosis and effective management of patients.

    Case Presentation: A 26-year-old Chinese man with SLE initially manifested cutaneous papulonodular mucinosis and developed acute Guillain-Barré syndrome and class V lupus nephritis 2 years later. His cutaneous nodules had not been idententified for 2 years and were resected by surgical procedures twice until SLE was diagnosed. Read More

    Molecular and cellular insights into Zika virus-related neuropathies.
    J Neurovirol 2017 Jan 26. Epub 2017 Jan 26.
    Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 21008, China.
    Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain-Barré syndrome (GBS) in the adult. In this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies. Read More

    Autoimmune diseases and HIV infection: A cross-sectional study.
    Medicine (Baltimore) 2017 Jan;96(4):e5769
    aDépartement de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon bPôle Information Médicale Evaluation Recherche des Hospices Civils de Lyon cDépartement de Maladies Infectieuses, Hôpital de la Croix-Rousse, Hospices Civils de Lyon dUniversité de Lyon, Université Lyon 1 eDépartement de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
    To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found among 5186 HIV-infected patients which represents a prevalence of 0. Read More

    Dengue and Zika viruses: lessons learned from the similarities between these Aedes mosquito-vectored arboviruses.
    J Microbiol 2017 Feb 26;55(2):81-89. Epub 2017 Jan 26.
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
    The currently spreading arbovirus epidemic is having a severe impact on human health worldwide. The two most common flaviviruses, dengue virus (DENV) and Zika virus (ZIKV), are transmitted through the same viral vector, Aedes spp. mosquitoes. Read More

    The impact of Zika virus in the brain.
    Biochem Biophys Res Commun 2017 Jan 17. Epub 2017 Jan 17.
    University of São Paulo, Department of Surgery, Stem Cell Laboratory, São Paulo, São Paulo, 05508-270, Brazil; School of Arts Sciences and Humanities, Department of Obstetrics, São Paulo, SP, 03828-000, Brazil. Electronic address:
    The recent outbreak of ZIKV in Brazil called the attention of the world because the effects of viral infection in the brain under development in fetuses. Consequences of vertical infection comprise brain malformation, especially microcephaly, eye and musculoskeletal abnormalities, among others. In adults, outcomes of infection include meningoencephalitis and Guillain-Barré Syndrome. Read More

    PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17 cell differentiation and regulating cytokine production.
    FASEB J 2017 Jan 17. Epub 2017 Jan 17.
    Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China;
    Experimental autoimmune neuritis (EAN) is a CD4(+) T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system. It has been replicated in an animal model of human inflammatory demyelinating polyradiculoneuropathy, Guillain-Barré syndrome. In this study, we evaluated the therapeutic efficacy of a selective inhibitor of the immunoproteasome subunit, low-MW polypeptide 7 (PR-957) in rats with EAN. Read More

    African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes.
    Infect Genet Evol 2017 Jan 14;49:134-137. Epub 2017 Jan 14.
    Laboratoire MIVEGEC, UMR 224 IRD/CNRS/UM, Montpellier, France. Electronic address:
    ZIKA virus (ZIKV) is a newly emerging arbovirus. Since its discovery 60years ago in Uganda, it has spread throughout the Pacific, Latin America and the Caribbean, emphasizing the capacity of ZIKV to spread to non-endemic regions worldwide. Although infection with ZIKV often leads to mild disease, its recent emergence in the Americas has coincided with an increase in adults developing Guillain-Barré syndrome and neurological complications in new-borns, such as congenital microcephaly. Read More

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