9,383 results match your criteria Guillain-Barre Syndrome
J Neurol 2018 Dec 7. Epub 2018 Dec 7.
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus, Denmark.
Objectives: To describe the epidemiology and clinical heterogeneity of Guillain-Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).
Methods: The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course. Read More
Neurol Genet 2018 Dec 26;4(6):e280. Epub 2018 Oct 26.
Rheumatology Research Center (N.K., A.T., H.H., D.M.), Center of Rare Diseases, and Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem; The Weizmann Institute (Y.E.-E., E.P.), Rehovot, Israel; Systems Immunity Research Institute (B.P.M.), Cardiff University, Cardiff, Wales, UK; and Hebrew University (O.S.-F., D.M.), Jerusalem, Israel.
Objective: To characterize all 4 mutations described for CD59 congenital deficiency.
Methods: The 4 mutations, p.Cys64Tyr, p. Read More
Comput Intell Neurosci 2018 5;2018:1576927. Epub 2018 Nov 5.
División Académica de Informática y Sistemas, Universidad Juárez Autónoma de Tabasco, Tabasco, Mexico.
Nowadays, Machine Learning methods have proven to be highly effective on the identification of various types of diseases, in the form of predictive models. Guillain-Barré syndrome (GBS) is a potentially fatal autoimmune neurological disorder that has barely been studied with computational techniques and few predictive models have been proposed. In a previous study, single classifiers were successfully used to build a predictive model. Read More
Ann Indian Acad Neurol 2018 Oct-Dec;21(4):318-321
Department of Critical Care Medicine, SPS Hospitals, Ludhiana, Punjab, India.
Scrub infection is an important differential of undifferentiated febrile illness in the subtropical and tropical countries. Neurological complications of scrub infection have a varied spectrum of presentation involving both the central nervous system, among which meningitis and meningoencephalitis are the most common presentations. The peripheral nervous system manifestations include Guillain-Barre syndrome (GBS) is not commonly reported. Read More
Ann Indian Acad Neurol 2018 Oct-Dec;21(4):315-317
Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Guillain-Barré syndrome (GBS) is an infrequent neurological complication of dengue viral infection. It is broadly divided into either acute inflammatory demyelinating variety or an axonal variety (acute motor axonal and acute sensory and motor axonal variants). Axonal variants are distinctly infrequent. Read More
J Neurol Sci 2018 Nov 2;396:254-255. Epub 2018 Nov 2.
Department of Epidemiology, General Hospital 71, Veracruz Norte Delegation, Mexican Institute of Social Security.
Microbes Infect 2018 Dec 6. Epub 2018 Dec 6.
Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Niterói, RJ, Brazil. Electronic address:
Hepatitis E virus is increasingly being associated with idiopathic neurological disease. We tested 325 stool samples from Brazilian children presenting acute flaccid paralysis or Guillain-Barré syndrome using a broadly reactive and sensitive Reverse-transcription Polymerase chain reaction. Hepatitis E genome was not detected in any of the samples tested. Read More
Neurol India 2018 Nov-Dec;66(6):1634-1643
Department of Neurology, Government Medical College Kota, Rajasthan, India.
Introduction: Our aim was to study dengue-related immune-mediated neurological complications (IMNC) during the recent epidemic.
Materials And Methods: This was a cross-sectional observational study of 79 IMNC cases from 1627 laboratory confirmed dengue cases from January 2015 to January 2016 and their follow-up for 3 months. According to the World Health Organization, cases were categorized into those having dengue fever (DF), and those having a severe syndrome that includes dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Read More
Eur J Paediatr Neurol 2018 Nov 20. Epub 2018 Nov 20.
Pediatric Clinic, Foundation IRCCS Policlinico "San Matteo", University of Pavia, Pavia, Italy.
Bickerstaff Brainstem Encephalitis (BBE) is a rare autoimmune encephalitis, characterized by acute ophthalmoplegia, ataxia and altered state of consciousness. Together with Guillan-Barrè Syndrome (GBS) and Miller-Fisher Syndrome, it forms a spectrum of post-infectious demyelinating diseases. Overlapping forms between BBE and GBS (BBE/GBS) are described in patients with lower limbs weakness and typical signs of BBE, suggesting a combined involvement of Central and Peripheral Nervous System (PNS), but only few reported cases are focused on pediatric population. Read More
Continuum (Minneap Minn) 2018 Dec;24(6):1753-1775
Purpose Of Review: Weakness is a common reason patients are seen in neurologic consultation. This article reviews the differential diagnosis of neuromuscular disorders in the intensive care unit (ICU), discusses the intensive care needs and evaluation of respiratory failure in patients with neuromuscular disorders, and provides a practical guide for management.
Recent Findings: Although primary neuromuscular disorders used to be the most common cause for weakness from peripheral nervous system disease in the ICU, a shift toward ICU-acquired weakness is observed in today's clinical practice. Read More
Cureus 2018 Sep 27;10(9):e3371. Epub 2018 Sep 27.
Oncology, Lynn Cancer Institute, Boca Raton, USA.
Pembrolizumab is a humanized monoclonal antibody that blocks the programmed cell death 1 (PD-1) pathway, thereby enhancing antitumor immunity. As the use of immune checkpoint inhibitors becomes more prevalent, so do immune-related adverse events associated with their use. The immune-related adverse events linked with this class of drugs are commonly seen and most of the time are classified as mild adverse events. Read More
JAMA Pediatr 2018 Nov 30. Epub 2018 Nov 30.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Importance: Acute flaccid myelitis (AFM) is an emerging poliolike illness of children whose clinical spectrum and associated pathogens are only partially described. The case definition is intentionally encompassing for epidemiologic surveillance to capture all potential AFM cases. Defining a restrictive, homogenous subpopulation may aid our understanding of this emerging disease. Read More
J Clin Med 2018 Nov 28;7(12). Epub 2018 Nov 28.
Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ministério da Saúde, RodoviaBR-316, km-07, Ananindeua67030-000, Pará, Brazil.
Introduction: The recent Zika virus(ZIKV) epidemic in Brazil was characterized by a range of different clinical presentations, particularly microcephaly, Guillain-Barré syndrome, and death. In this context, we determined the causal relationship between fatal microcephaly cases and ZIKV infection.
Methods: Twelve fatal cases of neonates, whose mothers were infected with ZIKV during pregnancy, were examined; cases included nine neonatal deaths due to microcephaly, one miscarriage, and two stillbirths. Read More
Rev Neurol 2018 Dec;67(11):464
IMSS. Instituto Mexicano del Seguro Social, Veracruz, Mexico.
Rev Neurol 2018 Dec;67(11):463-464
Facultad de Ciencias Medicas Doctor Miguel Enriquez, La Habana, Cuba.
Euro Surveill 2018 Nov;23(47)
The other members of the Spanish AFP Surveillance Working Group are listed at the end of this article.
Acute flaccid paralysis (AFP) surveillance is key for global polio eradication. It allows detecting poliovirus (PV) reintroductions from endemic countries. This study describes AFP surveillance in Spain from 1998 to 2015. Read More
J Neuroimmunol 2018 Nov 14;326:55-61. Epub 2018 Nov 14.
Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Electronic address:
Sulfatides have immunomodulatory functions, and play protective roles in multiple autoimmune diseases. In the present study, we showed that sulfatides ameliorated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin, which was associated with decreased proportions of Th1 and Th17 cells. Furthermore, compared control group, cells from sulfatide-treated rats exhibited lower potential in proliferation and IL-17 secretion in the presence of BPM or ConA in vitro. Read More
Sci Rep 2018 Nov 26;8(1):17385. Epub 2018 Nov 26.
Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that affects humans and can cause severe neurological complications, including Guillain-Barré syndrome and microcephaly. Since 2007 there have been three large outbreaks; the last and larger spread in the Americas in 2015. Actually, ZIKV is circulating in the Americas, Southeast Asia, and the Pacific Islands, and represents a potential pandemic threat. Read More
J Clin Neurosci 2018 Nov 23. Epub 2018 Nov 23.
Section of Neurophysiology, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:
Outcomes of Guillain Barre Syndrome (GBS), particularly those require mechanical ventilation have been reported from a number of Asian countries, albeit, scarcely from Pakistan. We conducted this study to determine the short-term outcomes of GBS and compare the results of mechanically ventilated and non-ventilated patients. Case records of patients admitted with GBS during 2011-2016 at a large tertiary care centre of Pakistan were retrospectively reviewed. Read More
Brain Dev 2018 Nov 21. Epub 2018 Nov 21.
Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Background: The initial symptoms of Guillain-Barre Syndrome (GBS) can be similar to a case of spontaneous spinal epidural hematoma (SSEH) located at the cervicothoracic junction. Therefore, SSEH may be misdiagnosed as GBS.
Case Report: A previously healthy 6-year-old girl presented with a 2-day history of progressive pain in the lower extremities and an inability to walk. Read More
Therapie 2018 Oct 26. Epub 2018 Oct 26.
London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.
The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More
Curr Top Med Chem 2018 Nov 20. Epub 2018 Nov 20.
Pharmacognosy and Phytotherapy Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700032. India.
Background: Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the World Health Organization. Read More
Drug Des Devel Ther 2018 6;12:3817-3824. Epub 2018 Nov 6.
Department of Immunology, Harbin Medical University, Heilongjiang Province, Harbin 150081, People's Republic of China,
Background: Guillain-Barré syndrome is an acute inflammatory demyelinating polyneuropathy that is characterized histologically by demyelination of peripheral nerves and nerve roots, infiltrates of T lymphocytes, and an inflammatory response that includes macrophage infiltrates. The aim of this study was to evaluate the effects of vasoactive intestinal peptide (VIP) in a rat model of experimental autoimmune neuritis (EAN).
Methods: Forty male Lewis rats were divided into a control group (N=10), an EAN group (N=10), an EAN group treated with 15 nmol of VIP (N=10), and an EAN group treated with 30 nmol of VIP (N=10). Read More
Viruses 2018 Nov 18;10(11). Epub 2018 Nov 18.
J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD 20850, USA.
Zika virus (ZIKV) is a neuropathic virus that causes serious neurological abnormalities such as Guillain-Barre syndrome in adults and congenital Zika syndrome (CZS) in fetuses, which makes it an important concern for global human health. A catalogue of cells that support ZIKV replication, pathogenesis, and/or the persistence of the virus still remains unknown. Here, we studied the behavior of the virus in human placenta (JEG-3) and human microglia (HMC3) cell lines in order to better understand how different host tissues respond during infection. Read More
Public Health 2018 Dec 16;165:146-151. Epub 2018 Nov 16.
Faculty of Science and Technology, The University of the West Indies, St Augustine, Trinidad and Tobago.
Objective: Mosquito-borne diseases continue to pose a threat to Latin America and the Caribbean. Zika virus disease entered the Caribbean in 2013 with increased reporting of cases across the region in 2016, affecting more than 50 countries. This study aimed to ascertain the knowledge of, attitudes and practices towards Zika virus disease among antenatal clinic attenders in Trinidad and Tobago during the 2016 outbreak. Read More
Viruses 2018 Nov 15;10(11). Epub 2018 Nov 15.
Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 Jingming South Road, Kunming 650500, China.
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that can cause severe disease, including congenital birth defect and Guillain-Barré syndrome during pregnancy. Although, several molecular diagnostic methods have been developed to detect the ZIKV, these methods pose challenges as they cannot detect early viral infection. Furthermore, these methods require the extraction of RNA, which is easy to contaminate. Read More
Trop Med Int Health 2018 Nov 16. Epub 2018 Nov 16.
Centre for Tropical Medicine, University of Brasília, Brasília, Federal District, Brazil.
Objective: To describe the factors associated with the development of Guillain-Barré syndrome, both infectious and non-infectious, during and after the A(H1N1) influenza pandemic in 2009 and the recent Zika virus epidemic in the Americas.
Method: Systematic review of literature on factors associated with the development of the Guillain-Barré syndrome published between 2007 and 2017 listed in EBSCO, MEDLINE, and LILACS databases. The quality of the studies was evaluated using the Newcastle Ottawa Scale. Read More
Pol Arch Intern Med 2018 Nov 16. Epub 2018 Nov 16.
Rev Neurol (Paris) 2018 Nov 12. Epub 2018 Nov 12.
Referral Center for Neuromuscular Diseases and ALS, AP-HM, Timone University Hospital, 13385 Marseille, France; INSERM UMR S 910, Aix-Marseille University, 13005 Marseille, France.
Introduction: A retrospective analysis was performed to document the clinical and electrophysiological features of Guillain-Barré syndrome (GBS) subtypes using different diagnostic criteria.
Methods: One hundred GBS patients were included. Clinical and laboratory features were analyzed, and patients were classified according to four sets of diagnostic criteria. Read More
Zhonghua Yi Xue Za Zhi 2018 Nov;98(41):3305-3306
Open Med (Wars) 2018 22;13:503-508. Epub 2018 Oct 22.
Department of Neurology, Brain Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Hangzhou China.
Purpose: To describe the clinical, electrophysiological, and lumbar magnetic resonance imaging (MRI) features of two cases of atypical Guillain-Barré syndrome (GBS). Methods We reported two GBS variant cases with initial and prominent symptoms of low back pain. We analysed their clinical, electrophysiological, and lumbar MRI features. Read More
J Neurol Sci 2018 Nov 6;396:84-85. Epub 2018 Nov 6.
Universidad del Rosario, Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Bogotá, Colombia.
J Peripher Nerv Syst 2018 Nov 13. Epub 2018 Nov 13.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, IRCCS Policlinico San Martino, Genova.
Background: Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy with a worldwide incidence of 0,81- 1,89 per 100,000 person-years. In Europe and North America only 5% of patients with GBS have axonal subtypes, which in South America and Asia account for 30-47% of cases.
Objective: To assess the annual incidence and clinical features of GBS in La Spezia area in Italy. Read More
Rev Esp Salud Publica 2018 Nov 15;92. Epub 2018 Nov 15.
Centro de Coordinación de Alertas y Emergencias Sanitarias. Ministerio de Sanidad, Consumo y Bienestar Social. Madrid. España.
By mid-2015, an increase in the number of cases of microcephaly among newborns and neurologic disorders was detected in the Northwest of Brazil, which was possibly associated with Zika virus infection. Later on, this phenomenon was also observed in several Latin-American countries. In February 2016, the World Health Organization (WHO) on this basis, declared a Public Health Emergency of International Concern. Read More
Clin Neurophysiol 2018 Dec 28;129(12):2586-2593. Epub 2018 Oct 28.
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
It is controversial as to whether the electrophysiological Guillain-Barré syndrome (GBS) subtypes can be diagnosed on the basis of a single study and which criteria sets and cut-offs should be used. Serial electrophysiologic studies have shown that a significant number of patients changed electrodiagnostic subtype largely because of the recognition of reversible conduction failure as a possible evidence of axonal pathology. However, other reports concluded that electrodiagnosis can be made by a single study, the subtypes depending on the characteristic of the criteria set applied. Read More
PLoS Negl Trop Dis 2018 Nov 12;12(11):e0006880. Epub 2018 Nov 12.
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States of America.
The recent emergence of Zika virus (ZIKV) in the Americas coincident with increased caseloads of microcephalic infants and Guillain-Barre syndrome has prompted a flurry of research on ZIKV. Much of the research is difficult to compare or repeat because individual laboratories use different virus isolates, growth conditions, and quantitative assays. Here we obtained three readily available contemporary ZIKV isolates and the prototype Ugandan isolate. Read More
Ceylon Med J 2018 Sep;63(3):149-150
Department of Internal Medicine, Teaching Hospital Batticaloa, Sri Lanka.
Nervenarzt 2018 Dec;89(12):1411-1427
Klinik für Neurologie, Klinikum Kassel, Mönchebergstr. 41-43, 34125, Kassel, Deutschland.
Neurological diseases frequently demanding admittance to a dedicated neurological intensive care unit (neurocritical care) comprise space-occupying ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, traumatic brain injury, status epilepticus, bacterial meningitis, myasthenic crisis and Guillain-Barré syndrome. Due to often necessary analgesia, sedation and mechanical ventilation, neuromonitoring should ideally be employed. This consists of bedside invasive and non-invasive methods for monitoring cerebral perfusion, oxygenation, metabolism and neurophysiology. Read More
WMJ 2018 Oct;117(4):160-163
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,
The report, "On a syndrome of radiculoneuritis with hyperalbuminosis of the cerebrospinal fluid without a cellular reaction. Remarks on the clinical characteristics and tracings of the tendon reflexes," published in 1916, included superb longitudinal clinical observations of progressive areflexic paralysis in 2 French soldiers, unique laboratory findings from the still new at that time technique of lumbar puncture, and electrophysiological studies. The classic observation of the albumino-cytologic dissociation in the spinal fluid, even over 100 years later, is still one of the most important laboratory findings used by clinicians to confirm the suspected diagnosis of the Acute Inflammatory Demyelinating Polyneuropathy, typically eponymously referred to as Guillain Barré Syndrome (GBS). Read More
Cureus 2018 Aug 24;10(8):e3202. Epub 2018 Aug 24.
Neurology, Bay Pines VA, Bay Pines, USA.
We report a case of a 61-year-old man with a history of squamous cell carcinoma of the lung presenting with rapidly progressive symmetric ascending weakness with areflexia. The weakness was quickly followed by respiratory decompensation requiring intubation. Lumbar puncture yielded cerebrospinal fluid with elevated protein (177 mg/dL), normal glucose (61 mg/dL), normal red blood cell count (0 per/µl), and normal white blood cell count (0 per/µL). Read More
Transpl Infect Dis 2018 Nov 7:e13021. Epub 2018 Nov 7.
Nephrology and Transplantation Unit, John Hunter Hospital, Newcastle, NSW, Australia.
Background: Guillain-Barré syndrome (GBS) is a common ascending polyneuropathy in adults. It is often associated with preceding viral or diarrhoeal illness with cytomegalovirus (CMV), Epstein-Barr virus (EBV), or Campylobacter jejuni. Solid organ transplant recipients are more susceptible to opportunistic infections with CMV than the general population as a result of immunosuppressive therapies to prevent graft rejection. Read More
Case Rep Crit Care 2018 4;2018:9708451. Epub 2018 Oct 4.
Nephrology Division, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Zika is an arbovirus infection mainly transmitted by the mosquito . In 2016, the burden of Zika epidemic in Brazil was significant. Patients affected by Zika virus can develop Guillain-Barré syndrome, evolving to muscle respiratory failure requiring mechanical ventilation. Read More
J Neurol Sci 2018 Nov 2. Epub 2018 Nov 2.
Dr DY Patil University, Pune, India.
J Neurol Sci 2018 Dec 25;395:207-209. Epub 2018 Oct 25.
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Am J Trop Med Hyg 2018 Nov 5. Epub 2018 Nov 5.
Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Paraná, Brazil.
Zika virus (ZIKV) infection is an emerging public health problem, associated with increased risk for Guillain-Barré syndrome and adverse fetal outcomes, including congenital microcephaly. Zika virus sexual transmission is known, but detection of the virus in different parts of the female reproductive tract is not well established. In this case report, we describe prolonged detection of ZIKV RNA in the vaginal secretion and endocervical mucosa from a Brazilian woman convalescent to ZIKV infection. Read More
J Vis Exp 2018 Oct 17(140). Epub 2018 Oct 17.
School of Laboratory Medicine and Life Sciences, Wenzhou Medical University; NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention;
The Zika virus (ZIKV) can induce inflammation in immunoprivileged organs (e.g., the brain and testis), leading to the Guillain-Barré syndrome and damaging the testes. Read More
Zhonghua Yu Fang Yi Xue Za Zhi 2018 Oct;52(10):1072-1077
Key Laboratory of Food Safety Risk Assessment of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
is a major cause of food-borne gastroenteritis worldwide. While mortality is low when people was infected with , morbidity imparted by post-infectious sequelae such as Guillain-Barré syndrome and irritable bowel syndrome is significantly noteworthy. Although fluoroquinolones and macrolides were the first line drug for the treatment of infections, there is a tough challenge in clinical treatment with high antimicrobial resistant rate and multi antimicrobial resistance arise. Read More
Muscle Nerve 2018 Nov 2. Epub 2018 Nov 2.
Department of Neurology, University Hospital Münster, Münster, Germany.
Introduction: Although patients with Guillain-Barré-Syndrome frequently require orotracheal intubation and tracheostomy, the incidence and relevance of neurogenic dysphagia prior to intubation and risk factors for prolonged need for a tracheal cannula, have not yet been identified.
Methods: Retrospective analysis of the medical records of 88 patients was performed. Clinical characteristics were compared between intubated and non-intubated, and between immediately decannulated and not immediately decannulated patients. Read More
Front Immunol 2018 17;9:2177. Epub 2018 Oct 17.
Division of Virology, Medical University of Innsbruck, Innsbruck, Austria.
Although neglected in the past, the interest on Zika virus (ZIKV) raised dramatically in the last several years. The rapid spread of the virus in Latin America and the association of the infection with microcephaly in newborns or Guillain-Barré Syndrome in adults prompted the WHO to declare the ZIKV epidemic to be an international public health emergency in 2016. As the virus gained only limited attention in the past, investigations on interactions of ZIKV with human complement are limited. Read More
Nat Commun 2018 11 1;9(1):4560. Epub 2018 Nov 1.
Infectious Diseases, The J. Craig Venter Institute, La Jolla, CA, 92037, USA.
Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently available. Here, we isolate and characterize four monoclonal antibodies (mAbs) from an infected patient that target the non-structural protein NS1. Read More