10,250 results match your criteria Guillain-Barre Syndrome


Neurological complications in patients with SARS-CoV-2 infection: a systematic review.

Arq Neuropsiquiatr 2020 May 1;78(5):290-300. Epub 2020 Jun 1.

Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.

Background: As the COVID-19 pandemic unfolds worldwide, different forms of reports have described its neurologic manifestations.

Objective: To review the literature on neurological complications of SARS-CoV-2 infection.

Methods: Literature search performed following systematic reviews guidelines, using specific keywords based on the COVID-19 neurological complications described up to May 10th, 2020. Read More

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http://dx.doi.org/10.1590/0004-282x20200051DOI Listing

Zika Virus NS3 Protease Pharmacophore Anchor Model and Drug Discovery.

Sci Rep 2020 Jun 2;10(1):8929. Epub 2020 Jun 2.

Bioinformatics Program, Taiwan International Graduate Program, Institute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.

Zika virus (ZIKV) of the flaviviridae family, is the cause of emerging infections characterized by fever, Guillain-Barré syndrome (GBS) in adults and microcephaly in newborns. There exists an urgent unmet clinical need for anti-ZIKV drugs for the treatment of infected individuals. In the current work, we aimed at the promising virus drug target, ZIKV NS3 protease and constructed a Pharmacophore Anchor (PA) model for the active site. Read More

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http://dx.doi.org/10.1038/s41598-020-65489-wDOI Listing

A confused patient with deranged liver function tests.

Pract Neurol 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Royal Preston Hospital, Lancashire Teaching Hospitals NHF Foundation Trust, Preston PR2 9HT, UK.

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http://dx.doi.org/10.1136/practneurol-2020-002594DOI Listing

Current Status of Zika Virus Vaccines: Successes and Challenges.

Vaccines (Basel) 2020 May 31;8(2). Epub 2020 May 31.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) in adults. The unprecedented nature of the epidemic and serious diseases associated with the viral infections prompted the global research community to understand the immunopathogenic mechanisms of the virus and rapidly develop safe and efficacious vaccines. This has led to a number of ZIKV vaccine candidates that have shown significant promise in human clinical trials. Read More

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http://dx.doi.org/10.3390/vaccines8020266DOI Listing

The P-MAPA immunomodulator partially prevents apoptosis induced by Zika virus infection in THP-1 cells.

Curr Pharm Biotechnol 2020 Jun 2. Epub 2020 Jun 2.

Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation/FIOCRUZ, Recif. Brazil.

Background: Zika virus is an emerging arbovirus of global importance. ZIKV infection is associated with a range of neurological complications such as the Congenital Zika Syndrome and Guillain Barré Syndrome. Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. Read More

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http://dx.doi.org/10.2174/1389201021666200602140005DOI Listing

Fc-gamma IIIa-V158F receptor polymorphism contributes to the severity of Guillain-Barré syndrome.

Ann Clin Transl Neurol 2020 Jun 2. Epub 2020 Jun 2.

Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka, 1212, Bangladesh.

Objective: Guillain-Barré syndrome (GBS) is a rare, life-threatening disorder of the peripheral nervous system. Immunoglobulin G Fc-gamma receptors (FcγRs) mediate and regulate diverse effector functions and are involved in the pathogenesis of GBS. We investigated whether the FcγR polymorphisms FcγRIIa H/R131 (rs1801274), FcγRIIIa V/F158 (rs396991), and FcγRIIIb NA1/NA2, and their haplotype patterns affect the affinity of IgG-FcγR interactivity and influence GBS susceptibility and severity. Read More

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http://dx.doi.org/10.1002/acn3.51072DOI Listing

The neurological manifestations of COVID-19: a review article.

Neurol Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

Results: Various neurological manifestations have been reported in the literature associated with COVID-19, which in the current study are classified into Central Nervous System (CNS) related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease, epilepsy, and Peripheral Nervous System (PNS) related manifestations such as hyposmia/anosmia, hypogeusia/ageusia, muscle pain, and Guillain-Barre syndrome.

Conclusion: During the current context of COVID-19 pandemic, physicians should be aware of wide spectrum of neurological COVID-19 sign and symptoms for early diagnosis and isolation of patients. In this regard, COVID-19 has been associated with many neurological manifestations such as confusion, anosmia, and ageusia. Read More

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http://dx.doi.org/10.1007/s10072-020-04486-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262683PMC

imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy.

Theranostics 2020 16;10(14):6430-6447. Epub 2020 May 16.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the noninvasive detection of ZIKV infection , which is necessary for elucidating the virus's mechanisms of viral replication and pathogenesis, as well as to accelerate the development of anti-ZIKV therapeutic strategies. : In this study, a recombinant ZIKV harbouring Nluc gene (ZIKV-Nluc) was designed, recovered, and purified. Read More

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http://dx.doi.org/10.7150/thno.43177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255039PMC

Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry.

Neurology 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurology. Complejo Hospitalario Universitario de Albacete, Albacete, Castilla-La Mancha, Spain.

Objective: The coronavirus disease 2019 (COVID-19) has spread worldwide since December 2019. Neurological symptoms have been reported as part of the clinical spectrum of the disease. We aim to determine whether neurological manifestations are common in hospitalized COVID-19 patients and to describe their main characteristics. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009937DOI Listing

SARS-CoV-2 and Guillain-Barré syndrome: AIDP variant with favorable outcome.

Eur J Neurol 2020 Jun 1. Epub 2020 Jun 1.

Division of Neurology, Department of Clinical Neuroscience, Geneva University Hospitals and University of Geneva, Faculty of Medicine, Geneva, Switzerland.

The entire world has been experiencing the outbreak of a novel infectious agent known as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which is responsible for the coronavirus disease 19 (COVID-19) . Life-threatening complications described in SARS-CoV-2 infected patients include acute respiratory distress syndrome, acute kidney failure and cardiac injury . Nonetheless, only few neurological complications have been described so far . Read More

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http://dx.doi.org/10.1111/ene.14368DOI Listing

Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model.

Virol Sin 2020 May 29. Epub 2020 May 29.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

Zika virus (ZIKV) is emerging as a significant pathogen worldwide and may cause severe neurological disorders such as fetal microcephaly and Guillain-Barre syndrome. No drug or listed vaccines are currently available for preventing ZIKV infection. As a major target of neutralizing, ZIKV envelop (E) protein usually used for vaccine development. Read More

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http://dx.doi.org/10.1007/s12250-020-00238-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256182PMC

High Levels of Il-19 in Patients with Chronic Inflammatory Demyelinating Polyneuropathy.

J Mol Neurosci 2020 May 29. Epub 2020 May 29.

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Immune-mediated neuropathies include some specific types such as acute and chronic inflammatory demyelinating polyneuropathy (AIDP and CIDP). Previous studies have demonstrated abnormal cellular or humoral immune responses in these conditions. Although aberrant regulation of several cytokines have been reported in AIDP and CIDP, the significance of interleukin 19 (IL-19) in these conditions have not been elucidated yet. Read More

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http://dx.doi.org/10.1007/s12031-020-01602-yDOI Listing

Diffuse large B-Cell lymphoma associated with paraneoplastic Guillain-Barré syndrome: A diagnostic and therapeutic challenge.

Hematol Oncol Stem Cell Ther 2020 May 20. Epub 2020 May 20.

Roswell Park Comprehensive Cancer Centre, Buffalo, NY, USA. Electronic address:

Paraneoplastic neurological syndromes are a rare manifestation of non-Hodgkin lymphoma and can make treatment of these patients more challenging. We report the case of a 67-year-old man with high grade diffuse large B-cell lymphoma who presented with severe paraneoplastic Guillain-Barré syndrome. He was treated with intravenous immunoglobulin therapy and definitive chemoimmunotherapy, and achieved a full neurological recovery. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.05.008DOI Listing

[Anti-GQ1b syndrome. A child with Miller-Fisher-Bickerstaff syndrome].

Arch Argent Pediatr 2020 Jun;118(3):e333-e337

Sala 3ª de Internación de Clínica Pediátrica del Hospital Interzonal de Agudos Especializado en Pediatría Superiora Sor María Ludovica de La Plata.

Miller-Fisher syndrome and Bickerstaff brainstem encephalitis, among others, constitute the anti-GQ1b syndrome, with a common immune pathophysiologic pathway characterized by the presence of anti-GQ1b antibodies, which react against the different nervous system GQ1b sites according to their different accessibility. The Miller-Fisher syndrome has a prevalence of 0.09 cases per 100 000 people-year but there are not epidemiological studies about Bickerstaff brainstem encephalitis, that it seems to be less frequent. Read More

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http://dx.doi.org/10.5546/aap.2020.e333DOI Listing

New clinical manifestation of COVID-19 related Guillain-Barrè syndrome highly responsive to intravenous immunoglobulins: two Italian cases.

Neurol Sci 2020 May 28. Epub 2020 May 28.

Neurology Unit, Galliera Hospital, Via Mura delle Cappuccine 14, 16128, Genova, Italy.

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http://dx.doi.org/10.1007/s10072-020-04484-5DOI Listing

Guillain-Barre Syndrome, Neuroborreliosis, or Both.

Cureus 2020 Apr 25;12(4):e7823. Epub 2020 Apr 25.

Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA.

Guillain-Barre syndrome (GBS) is an acute paralytic neuropathy. Limited reports of GBS caused by tick-borne pathogens exist. Lyme disease is a tick-borne infectious disease that is commonly caused by Borrelia burgdorferi. Read More

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http://dx.doi.org/10.7759/cureus.7823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249767PMC

COVID-19-Associated Miller Fisher Syndrome: MRI Findings.

AJNR Am J Neuroradiol 2020 May 28. Epub 2020 May 28.

From the Department of Radiology, Weill Cornell Medical Center/New York Presbyterian Hospital, New York, New York.

Miller Fisher syndrome, also known as Miller Fisher variant of Guillain-Barré syndrome, is an acute peripheral neuropathy that can develop after exposure to various viral, bacterial, and fungal pathogens. It is characterized by a triad of ophthalmoplegia, ataxia, and areflexia. Miller Fisher syndrome has recently been described in the clinical setting of the novel coronavirus disease 2019 (COVID-19) without accompanying imaging. Read More

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http://dx.doi.org/10.3174/ajnr.A6609DOI Listing

The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries.

J Neurol Sci 2020 May 7;414:116884. Epub 2020 May 7.

Pakistan International Neuroscience Society, Neurology, Aga Khan University, Karachi, Pakistan.

A comprehensive review of the neurological disorders reported during the current COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypogeusia, and dysgeusia are frequent early symptoms of coronavirus infection. Respiratory failure, the lethal manifestation of COVID-19, responsible for 264,679 deaths worldwide, is probably neurogenic in origin and may result from the viral invasion of cranial nerve I, progressing into rhinencephalon and brainstem respiratory centers. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204734PMC

Guillain-Barré syndrome related to SARS-CoV-2 infection.

Neurol Neuroimmunol Neuroinflamm 2020 09 27;7(5). Epub 2020 May 27.

From the Service de Neurologie (K.B., P.V., L.K., J.-B.C., J.S.), Hôpitaux Universitaires de Strasbourg; Service de Neurologie (M.M.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche; Service de Neuroradiologie (S.B.), Hôpitaux Universitaires de Strasbourg; Institut de Biologie Structurale (IBS) (B.N., P.M.), Université de Grenoble Alpes, CEA, CNRS; Laboratoire de virologie (B.N., P.M.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche; Service d'Accueil des Urgences (F.B.), Hôpitaux Universitaires de Strasbourg; and Service de Réanimation Polyvalente Chirurgicale (A.G.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche, France.

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http://dx.doi.org/10.1212/NXI.0000000000000785DOI Listing
September 2020

Clinical features of Guillain-Barré syndrome patients with elevated serum creatine kinase levels.

BMC Neurol 2020 May 27;20(1):214. Epub 2020 May 27.

Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: It is not well defined whether Guillain-Barré syndrome (GBS) patients with elevated serum creatine kinase (CK) levels have characteristic clinical features and are related to the subgroups of GBS.

Methods: We retrospectively studied 51 consecutive patients with GBS, who visited our hospital, and compared clinical, laboratory and electrophysiological findings between patients with and without elevated CK levels.

Results: Of 51 patients, 14 patients (27%) showed an elevation of serum CK levels. Read More

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http://dx.doi.org/10.1186/s12883-020-01796-zDOI Listing

Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms.

J Neurol 2020 May 26. Epub 2020 May 26.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, People's Republic of China.

Coronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2), has become a global pandemic threat. The potential involvement of COVID-19 in central nervous system (CNS) has attracted considerable attention due to neurological manifestations presented throughout the disease process. In addition, SARS-CoV-2 is structurally similar to SARS-CoV, and both bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Read More

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http://dx.doi.org/10.1007/s00415-020-09929-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249973PMC

Novel Coronavirus (COVID-19)-Associated Guillain-Barré Syndrome: Case Report.

J Clin Neuromuscul Dis 2020 06;21(4):240-242

Department of Neurology and Neuroscience Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CND.0000000000000309DOI Listing

Relapsing Bickerstaff Brainstem Encephalitis After Autologous Stem Cell Transplant.

J Clin Neuromuscul Dis 2020 Jun;21(4):225-229

Department of Neurology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, Brain and Mind Research Institute, New York, NY.

Bickerstaff brainstem encephalitis, widely considered to be associated with Miller Fisher and Guillain-Barré syndromes, is a rare disease state defined by the triad of ophthalmoplegia, ataxia, and decreased consciousness. The presence of central nervous system involvement, commonly in the form of impaired arousal, solidifies it as a unique entity. We present a case of this rare syndrome after autologous stem cell transplant. Read More

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http://dx.doi.org/10.1097/CND.0000000000000282DOI Listing

Guillain-Barré syndrome of a patient under bortezomib treatment.

Farm Hosp 2020 Mar 1;44(2):77-78. Epub 2020 Mar 1.

Pharmacy Service, Hospital Santa Bárbara, Puertollano, Ciudad Real. Spain..

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http://dx.doi.org/10.7399/fh.11340DOI Listing

SARS-CoV-2 Infection Leads to Neurological Dysfunction.

J Neuroimmune Pharmacol 2020 06 23;15(2):167-173. Epub 2020 May 23.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demonstrate headache, nausea and vomiting, up to 40% present also experience dizziness, confusion, cerebrovascular disease, muscle pain, ataxia and seizures. Loss of taste and smell, defects in visual acuity and pain occur in parallel. Read More

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http://dx.doi.org/10.1007/s11481-020-09924-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244399PMC

Association of matrix metalloproteinase-9 polymorphism with severity of Guillain-Barré syndrome.

J Neurol Sci 2020 May 16;415:116908. Epub 2020 May 16.

Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka 1212, Bangladesh. Electronic address:

Guillain-Barré syndrome (GBS) is an immune-mediated neurological disorder with a multifaceted nature. Infectious agents and immune-response genetic host factors may contribute to the development of GBS. The matrix metalloproteinase-9 (MMP-9), an enzyme is upregulated by pro-inflammatory cytokines and might play an important role in the pathogenesis of GBS. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116908DOI Listing

Is COVID-19-related Guillain-Barré syndrome different?

Brain Behav Immun 2020 May 20. Epub 2020 May 20.

Department of Neurology, King George Medical University, Lucknow, UP, India.

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http://dx.doi.org/10.1016/j.bbi.2020.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239011PMC

Incidence, risk factors, and health service burden of sequelae of campylobacter and non-typhoidal salmonella infections in England, 2000-2015: A retrospective cohort study using linked electronic health records.

J Infect 2020 May 21. Epub 2020 May 21.

Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, OX2 6GG, United Kingdom; NIHR Health Protection Research Unit, Gastrointestinal Infections Theme, University of Oxford, Oxford, United Kingdom.

Background: Reactive arthritis, irritable bowel syndrome (IBS), Guillain-Barré syndrome, ulcerative colitis, and Crohn's disease may be sequelae of Campylobacter or non-typhoidal Salmonella (NTS) infections. Proton pump inhibitors (PPI) and antibiotics may increase the risk of gastrointestinal infections (GII); however, their impact on sequelae onset is unclear. We investigated the incidence of sequelae, their association with antibiotics and PPI prescription, and assessed the economic impact on the NHS. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.05.027DOI Listing

SARS-CoV-2-associated Guillain-Barré syndrome with dysautonomia.

Muscle Nerve 2020 May 23. Epub 2020 May 23.

Department of Neurology, Veterans Affairs Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/mus.26988DOI Listing

"Claw hand with a unilateral onset" as a regional variant of Guillain-Barre' syndrome: A case report.

Medicine (Baltimore) 2020 May;99(20):e20227

Department of Neurology, Third Central Hospital of Tianjin.

Rationale: Although distal nerves located at sites prone to compression are susceptible to autoimmune attack, Guillain-Barre' syndrome (GBS) with exclusive hand muscle involvement is rarely found in clinics. All reported patients presented with a special variant - finger extensor weakness, especially claw hand caused by predominant ulnar extensor involvement. Similar to typical GBS, these patients showed bilateral symmetric onset with rapid clinical progression. Read More

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http://dx.doi.org/10.1097/MD.0000000000020227DOI Listing

Miller Fisher Variant of Guillain-Barré Syndrome in a Child.

J Pediatr Neurosci 2020 Jan-Mar;15(1):60-62. Epub 2020 Mar 19.

Department of Paediatrics, Grant Government Medical College and Sir Jamsetjee Jejeebhoy Group of Hospitals, Mumbai, Maharashtra, India.

Miller Fisher syndrome (MFS), a rare form of Guillain-Barré Syndrome, presents with the classical triad of ophthalmoplegia, areflexia, and ataxia. We describe the case of a 7-year-old boy who presented with diplopia, speech difficulty, dysphagia, gait disturbance, and difficulty in eyeball movements since 5 days. On examination, the child was having ataxia, areflexia, ophthalmoplegia, drooling of saliva, dysphonia, and absent gag reflex. Read More

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http://dx.doi.org/10.4103/JPN.JPN_146_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227762PMC

Editorial - High dose intravenous immunoglobulins as a therapeutic option for COVID-19 patients.

Eur Rev Med Pharmacol Sci 2020 05;24(9):5178-5179

Department of Human Physiology and Pharmacology, "Sapienza" University of Rome, Rome, Italy.

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http://dx.doi.org/10.26355/eurrev_202005_21214DOI Listing

The Ultimate Poker Face: A Case Report of Facial Diplegia, a Guillain-Barré Variant.

Clin Pract Cases Emerg Med 2020 May 23;4(2):150-153. Epub 2020 Apr 23.

Brooke Army Medical Center, Department of Emergency Medicine, Fort Sam Houston, Texas.

Introduction: Facial diplegia, a rare variant of Guillain-Barré syndrome (GBS), is a challenging diagnosis to make in the emergency department due to its resemblance to neurologic Lyme disease.

Case Report: We present a case of a 27-year-old previously healthy man who presented with bilateral facial paralysis.

Discussion: Despite the variance in presentation, the recommended standard of practice for diagnostics (cerebrospinal fluid albumin-cytological dissociation) and disposition (admission for observation, intravenous immunoglobulin, and serial negative inspiratory force) of facial diplegia are the same as for other presentations of GBS. Read More

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http://dx.doi.org/10.5811/cpcem.2020.2.45556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220008PMC

Neurologic complications of COVID-19.

Am J Emerg Med 2020 May 16. Epub 2020 May 16.

Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, United States of America.

Background: Much of the focus regarding the global pandemic of coronavirus disease of 2019 (COVID-19) has been on the cardiovascular, pulmonary, and hematologic complications. However, neurologic complications have arisen as an increasingly recognized area of morbidity and mortality.

Objective: This brief report summarizes the neurologic complications associated with COVID-19 with an emphasis on the emergency medicine clinician. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229718PMC

Post SARS-CoV-2 Guillain-Barré syndrome.

Clin Neurophysiol 2020 07 11;131(7):1652-1654. Epub 2020 May 11.

Service de Neurologie, APHP, Hôpital Avicenne, Hôpitaux Universitaires de Paris - Seine Saint Denis, Sorbonne Paris Nord, Bobigny, France; Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex, 75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212990PMC

COVID 19: Neuromuscular Manifestations.

Ann Indian Acad Neurol 2020 Apr 21;23(Suppl 1):S40-S42. Epub 2020 Apr 21.

Dean, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

COVID-19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. Neuromuscular manifestations have been reported uncommonly in these early stages of the analysis. This manuscript studies the available information on the neuromuscular manifestations of COVID-19. Read More

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http://dx.doi.org/10.4103/aian.AIAN_309_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213035PMC

Guillain-Barré Syndrome in a Crohn's disease patient treated with vedolizumab.

J Crohns Colitis 2020 May 17. Epub 2020 May 17.

Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP, BR.

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http://dx.doi.org/10.1093/ecco-jcc/jjaa101DOI Listing

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2.

Eur J Neurol 2020 May 16. Epub 2020 May 16.

Department of Neurology, 4Brain, Gent University Hospital, Gent, Belgium.

Introduction: Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported. The aim of this study was to perform a review to describe neurological manifestations in patients with COVID-19 and possible neuro-invasive mechanisms of Sars-CoV-2.

Methods: Pubmed, WebOfScience and Covid-dedicated databases were searched for the combination of COVID-19 terminology and neurology terminology up to May 10 2020. Read More

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http://dx.doi.org/10.1111/ene.14329DOI Listing

Lessons of the month: Herpetic viral dermatomyositis.

Clin Med (Lond) 2020 May;20(3):e12-e14

Aster Medcity, Kochi, India.

We present the case of a man who presented with severe left lower back pain radiating to the anterior aspect of left thigh. He also had fever and headache. Due to the exquisite tenderness along the inguinal region, the possibility of a psoas abscess was considered. Read More

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http://dx.doi.org/10.7861/clinmed.2020-0078DOI Listing

Novel coronavirus disease 2019 (COVID-19) and neurodegenerative disorders.

Dermatol Ther 2020 May 15:e13591. Epub 2020 May 15.

Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

During the last few months, the whole humanity is experiencing largest and most severe sudden influx of COVID-19 outbreak caused by the novel coronavirus (CoV) originated from Wuhan, China. According to the WHO reports, total 3 862 676 positive cases and 265 961 deaths have been recorded worldwide due to COVID-19 infection as of May 9, 2020. CoVs are a large family of viruses (enveloped, single-stranded RNA viruses), which includes severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV). Read More

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http://dx.doi.org/10.1111/dth.13591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261984PMC

Neurological Manifestations of COVID-19: A systematic review and current update.

Acta Neurol Scand 2020 May 15. Epub 2020 May 15.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest, Liverpool, UK.

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in December of 2019 in the city of Wuhan, China. Since the outbreak, various reports detail its symptoms and outcomes, primarily focusing on respiratory complications. However, reports are emerging of the virus' effects systemically, including that of the nervous system. Read More

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http://dx.doi.org/10.1111/ane.13266DOI Listing

Autoimmune Peripheral Neuropathies and Contribution of Antiganglioside/Sulphatide Autoantibody Testing.

Mediterr J Rheumatol 2020 Mar 31;31(1):10-18. Epub 2020 Mar 31.

Aix Marseille Université, Institut de Neurosciences de la Timone, Medicine Faculty, Marseille, France.

Peripheral immune-mediated polyneuropathies (IMPN) are a diverse group of rare neurological illnesses characterized by nerve damage. Leading morphological features are mostly nerve fibre demyelination or combination of axonal damage and demyelination. There has been remarkable progress in the clinical and electrophysiological categorization of acute (fulminant, life-threatening) and chronic (progressive/remitting-relapsing) immune-mediated neuropathies recently. Read More

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http://dx.doi.org/10.31138/mjr.31.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219652PMC

Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2.

J Clin Neurosci 2020 May 14. Epub 2020 May 14.

Medical resident at the Department of Medical Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

We present a case of facial diplegia after 10 days of SARS-CoV-2 confirmed infection symptoms in a 61 year old patient without prior clinically relevant background. There are few known cases of Guillain-Barré Syndrome (GBS) related to SARS-CoV-2 infection; we propose this case as a rare variant of GBS in COVID-19 infection context, due to Its chronology, clinical manifestations and cerebrospinal fluid (CSF) findings. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221378PMC

COVID-19 and Guillain-Barré syndrome.

Rev Neurol (Paris) 2020 May 14. Epub 2020 May 14.

Honorary professor, Dr DY Patil University, Pune, India.

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http://dx.doi.org/10.1016/j.neurol.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221398PMC

Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital.

Neurol Sci 2020 May 12. Epub 2020 May 12.

Neurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy associated with dysimmune processes, often related to a previous infectious exposure. During Italian severe acute respiratory syndrome coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Read More

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http://dx.doi.org/10.1007/s10072-020-04449-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216127PMC

Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection.

Viruses 2020 May 9;12(5). Epub 2020 May 9.

MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.

Zika virus (ZIKV; Flaviviridae) is a mosquito-borne flavivirus shown to cause fetal abnormalities collectively known as congenital Zika syndrome and Guillain-Barré syndrome in recent outbreaks. Currently, there is no specific treatment or vaccine available, and more effort is needed to identify cellular factors in the viral life cycle. Here, we investigated interactors of ZIKV envelope (E) protein by combining protein pull-down with mass spectrometry. Read More

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http://dx.doi.org/10.3390/v12050524DOI Listing
May 2020
3.279 Impact Factor