140 results match your criteria Guidelines in Practice [Journal]


Changes in Emergency Department Concordance with Guidelines for the Management of Food-Induced Anaphylaxis: 1999-2001 versus 2013-2015.

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Massachusetts General Hospital, Boston, MA.

Background: Awareness about food allergy and food-induced anaphylaxis (FIA) has increased dramatically over the past decade. It remains unclear, however, whether concordance with guidelines for FIA management has improved over time.

Objective: Our objective was to describe changes in emergency department (ED) concordance with guidelines for FIA management. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.004DOI Listing
April 2019
1 Read

Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma.

J Allergy Clin Immunol Pract 2019 Apr 3. Epub 2019 Apr 3.

Allergy, Asthma & Clinical Immunology, The Alfred Hospital, Melbourne, Australia; Public Health & Preventive Medicine, Monash University, Melbourne, Australia.

Severe asthma is complex and heterogeneous; ad hoc outpatient assessment can be suboptimal. Systematic evaluation improves outcomes and is recommended by international guidelines. Electronic templates improve physician performance and clinical processes, and may be useful in severe asthma systematic evaluation. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.042DOI Listing
April 2019
4 Reads

Clinical Aspects of STAT3 Gain-of-Function Germline Mutations: A Systematic Review.

J Allergy Clin Immunol Pract 2019 Feb 27. Epub 2019 Feb 27.

Pediatric Pulmonology Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France; Université de Nice-Sophia Antipolis, Nice, France. Electronic address:

Background: Signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) germline mutations have been recently described. A comprehensive overview of this early-onset multiorgan autoimmune and lymphoproliferative disease has not yet been compiled.

Objective: We have conducted a systematic review of published STAT3 GOF cases to describe clinical, diagnostic, and therapeutic aspects of the disease. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.018DOI Listing
February 2019
1 Read

Guiding Principles for the Recognition, Diagnosis, and Management of Infants with Anaphylaxis: An Expert Panel Consensus.

J Allergy Clin Immunol Pract 2019 Apr 5;7(4):1148-1156.e5. Epub 2019 Feb 5.

Division of Allergy and Immunology, University of Tennessee Health Science Center, Memphis, Tenn.

Infant anaphylaxis is an emerging risk, with food allergy the most common cause. Although the presentation of anaphylaxis involves the same systems as in older children and adults, there are real-world challenges to identifying symptoms of an allergic emergency in nonverbal children, as well as implementing optimal treatment. Recognition of anaphylaxis in infants can be challenging because allergic symptoms and certain normal infant behaviors may overlap. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.10.052DOI Listing
April 2019
5 Reads

Preventing Peanut Allergy: Where Are We Now?

J Allergy Clin Immunol Pract 2019 Feb;7(2):367-373

Department of Women and Children's Health, School of Life Course Sciences, King's College London, Guys' Hospital, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, Guys' Hospital, London, United Kingdom; Children's Allergy Service, Evelina London Children's Hospital, Guy's and St. Thomas's National Health Service Foundation Trust, London, United Kingdom. Electronic address:

Peanut allergy affects 1% to 3% of the Western world, usually begins in early childhood, is rarely outgrown, and has no currently approved treatment. The identification and application of prevention strategies is therefore essential. In 2015, the Learning Early About Peanuts study findings found that early consumption of peanut protein was effective in preventing peanut allergy in high-risk children as compared with peanut avoidance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183072
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http://dx.doi.org/10.1016/j.jaip.2018.11.005DOI Listing
February 2019
6 Reads

Caregiver-Reported Asthma Control Predicts Future Visits, Independent of Guideline-Based Control Measures.

J Allergy Clin Immunol Pract 2019 Jan 28. Epub 2019 Jan 28.

Department of Public Health, Dell Medical School, University of Texas, Austin, TX. Electronic address:

Background: It is unknown whether caregiver perception of a child's asthma control, independent of guideline-based asthma control assessment, is a predictor of future acute visits.

Objective: To determine whether caregiver-reported asthma control is an indicator of future risk of acute visit.

Methods: Two study populations of low-income, minority 5- to 17-year-old children with persistent asthma were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193009
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http://dx.doi.org/10.1016/j.jaip.2018.12.030DOI Listing
January 2019
7 Reads

Antibiotic Prophylaxis for Dental Treatment in Patients with Immunodeficiency.

J Allergy Clin Immunol Pract 2019 Mar 21;7(3):819-823. Epub 2019 Jan 21.

Division of Allergy and Immunology, Department of Pediatrics, University of South Florida, Johns Hopkins-All Children's Hospital, St Petersburg, Fla. Electronic address:

Routine antibacterial prophylaxis is recommended before dental procedures in select patient populations. Currently, no guidelines are in place for routine prophylaxis before dental procedures in patients with primary immunodeficiency diseases. We review risk factors and provide recommendations on routine dental care and antibacterial prophylaxis in patients with primary immunodeficiency diseases. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.016DOI Listing
March 2019
1 Read

Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma.

J Allergy Clin Immunol Pract 2019 Jan 14. Epub 2019 Jan 14.

Division of Allergy, Asthma, and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Va; Beirne Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Va; Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Va.

Background: Children with severe asthma have frequent exacerbations despite guidelines-based treatment with high-dose corticosteroids. The importance of refractory lung inflammation and infectious species as factors contributing to poorly controlled asthma in children is poorly understood.

Objective: To identify prevalent granulocyte patterns and potential pathogens as targets for revised treatment, 126 children with severe asthma underwent clinically indicated bronchoscopy. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.027DOI Listing
January 2019
7 Reads

Emergency Management of Anaphylaxis Due to an Unknown Trigger: An 8-Year Follow-Up Study in Canada.

J Allergy Clin Immunol Pract 2019 Apr 23;7(4):1166-1173.e1. Epub 2018 Nov 23.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, Montreal, Quebec, Canada.

Background: Anaphylaxis due to unknown trigger (AUT) is anaphylaxis not explained by a proved or presumptive cause or stimulus at the time of the reaction. Research describing the management and follow-up of AUT is limited.

Objective: To assess and compare the demographic and clinical characteristics and the management of adult and pediatric AUT cases across Canada. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.11.015DOI Listing
April 2019
5 Reads

What Is the Role of Increasing Inhaled Corticosteroid Therapy in Worsening Asthma in Children?

J Allergy Clin Immunol Pract 2019 Mar 13;7(3):842-847. Epub 2018 Nov 13.

Department of Pediatrics, Section of Allergy and Clinical Immunology, University of Manitoba, Winnipeg, MB, Canada.

The treatment of "yellow zone," or worsening, asthma in children remains controversial. The 2018 Global Initiative for Asthma strategy recommends increasing the dose of inhaled corticosteroid (ICS) for the short (1-2 weeks) or longer (3 months) term in children older than 5 years with worsening asthma. In contrast, the National Heart, Lung, and Blood Institute's Expert Panel Report 3 guideline for the diagnosis and management of asthma notes that doubling the dose of ICS therapy is "not sufficient" in worsening asthma, as does the Canadian Thoracic Society guideline on asthma management in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183066
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http://dx.doi.org/10.1016/j.jaip.2018.10.004DOI Listing
March 2019
2 Reads

Evidence-based considerations regarding the US and international guidelines for chronic urticaria.

Authors:
Miles Weinberger

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):2174

University of Iowa, Iowa City, Iowa; University of California San Diego, Rady Children's Hospital, San Diego, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.07.010DOI Listing
May 2018
3 Reads

A Simple Score for Future Risk Prediction in Patients with Controlled Asthma Who Undergo a Guidelines-Based Step-Down Strategy.

J Allergy Clin Immunol Pract 2019 Apr 25;7(4):1214-1221.e3. Epub 2018 Oct 25.

Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Department of Medicine, Barcelona, Spain.

Background: The minimum controlling dose of treatment must be established in patients with asthma, but the outcome of step-down is unpredictable.

Objective: To identify factors associated with risk of control loss when stepping down asthma treatment and to develop a score to predict this risk.

Methods: A prospective, multicenter study including adults with well-controlled asthma was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183067
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http://dx.doi.org/10.1016/j.jaip.2018.10.017DOI Listing
April 2019
20 Reads

Validation of Asthma Control Assessment Among Urban Adolescents Using the Asthma Control and Communication Instrument.

J Allergy Clin Immunol Pract 2019 Mar 11;7(3):962-968.e1. Epub 2018 Oct 11.

University of Rochester School of Medicine, Rochester, NY.

Background: The National Institutes of Health guidelines recommend questionnaires to assess asthma control, but there are few self-reported asthma morbidity surveys validated among urban, African American, Hispanic, and/or poor adolescents. The Asthma Control and Communication Instrument (ACCI) is a 12-item self-reported questionnaire previously validated among a diverse adult population, but not among adolescents.

Objective: To assess the ability of the ACCI to accurately describe asthma control in an urban adolescent population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183065
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http://dx.doi.org/10.1016/j.jaip.2018.10.001DOI Listing
March 2019
3 Reads

Early Exposure to Cow's Milk Protein Is Associated with a Reduced Risk of Cow's Milk Allergic Outcomes.

J Allergy Clin Immunol Pract 2019 Feb 26;7(2):462-470.e1. Epub 2018 Sep 26.

Centre for Food and Allergy Research, Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia. Electronic address:

Background: Overall early exposure to allergenic foods in the infant's diet is a new strategy for preventing food allergy to that allergen, but the optimal timing of exposure for different allergens is not known.

Objectives: We aimed to examine the relationship between exposure to cow's milk protein in the first 3 months of life and risk of cow's milk allergy at age 12 months.

Methods: HealthNuts is a longitudinal population-based food allergy study that recruited 5,276 twelve-month-old infants. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.08.038DOI Listing
February 2019
41 Reads

Chronic Spontaneous Urticaria: The Devil's Itch.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1097-1106

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC.

Chronic urticaria is defined as the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week. It is divided into chronic inducible urticarias and chronic spontaneous urticaria, previously termed chronic idiopathic urticaria. The latter designation emphasizes that patients can experience urticaria independent of any exogenous stimulus even if one can define circumstances that may worsen symptoms. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061968PMC
February 2018
5 Reads

Patterns of Carriage of Prescribed Adrenaline Autoinjectors in 10- to 14-Year-Old Food-Allergic Students: A Population-Based Study.

J Allergy Clin Immunol Pract 2019 Feb 19;7(2):437-443. Epub 2018 Jul 19.

Murdoch Children's Research Institute, Parkville, Victoria, Australia; Royal Children's Hospital, Parkville, Victoria, Australia; Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Background: Adolescence is well recognized as a period of increased risk for severe and fatal food-induced anaphylaxis. Current Australian adrenaline autoinjector (AAI) prescription guidelines therefore suggest that consideration be given to AAI prescription in all adolescents with a food allergy. To date, however, few studies have assessed the AAI carriage behavior of adolescents prescribed AAI devices. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.06.025DOI Listing
February 2019
15 Reads

Development and Validation of Personalized Prediction to Estimate Future Risk of Severe Exacerbations and Uncontrolled Asthma in Patients with Asthma, Using Clinical Parameters and Early Treatment Response.

J Allergy Clin Immunol Pract 2019 Jan 21;7(1):175-182.e5. Epub 2018 Jun 21.

Department of Medical Decision Making, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address:

Background: Current level of asthma control can be easily assessed by validated instruments, but it is currently difficult to assess individuals' level of future risk.

Objective: Develop, and validate, a risk prediction score for level of future risk, including patient characteristics and information on early treatment response.

Methods: We used data of 304 adult patients with asthma from a 12-month primary care randomized controlled trial with 3-monthly assessments. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.06.007DOI Listing
January 2019
3 Reads

A Comparison of the United States and International Perspective on Chronic Urticaria Guidelines.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1144-1151. Epub 2018 May 18.

University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Urticaria is a heterogeneous skin disorder that may be acute or chronic and is defined by the appearance of wheals, angioedema, or both. The European perspective is expressed in a recent international guideline and the American perspective has been based on the US Joint Task Force chronic urticaria practice parameter published in 2014. Both the international guideline (initiated by the European societies European Academy of Allergology and Clinical Immunology [EAACI]/Global Allergy and Asthma European Network [GALEN]/European Dermatology Forum [EDF] in collaboration with the World Allergy Organization [WAO]) and the US (American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology) guideline have been developed to help direct primary care physicians and specialists in the management of their patients with urticaria. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.012DOI Listing
May 2018
7 Reads

Explaining the Amount and Consistency of Medical Care and Self-Management Support in Asthma: A Survey of Primary Care Providers in France and the United Kingdom.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1916-1925.e7. Epub 2018 May 9.

Respiratory Medicine, Croix-Rousse University Hospital, Lyon, France; Department of Pharmacoepidemiology, PELyon-EA 7425-HESPER-Claude Bernard Lyon 1 University, Lyon, France.

Background: The quality of asthma primary care may vary between countries, health care practices, and health care professionals (HCPs). Identifying and explaining such differences is critical for health services improvement.

Objectives: To examine the quality of asthma primary care in France and United Kingdom, and identify within-country and between-country predictors amenable to intervention. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.04.039DOI Listing
May 2018
5 Reads

The Burden of Rhinitis and the Impact of Medication Management within the Community Pharmacy Setting.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1717-1725. Epub 2018 Mar 29.

Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia; Sydney Local Health District, Sydney, New South Wales, Australia.

Background: The burden of rhinitis is high. It is unknown to what extent this burden is related to inappropriate medication use.

Objective: This study aimed to identify the way in which people with rhinitis medicate their condition and to evaluate the appropriateness of this medication management. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.01.028DOI Listing
March 2018
2 Reads

Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1898-1906.e1. Epub 2018 Mar 30.

Department of Infectious Disease Epidemiology, Robert Koch-Institut, Berlin, Germany. Electronic address:

Background: Current guidelines recommend intramuscular administration of epinephrine as the first-line drug for the emergency treatment of severe allergic reactions (anaphylaxis), but no randomized trial evidence supports this consensus.

Objective: We aimed to assess anaphylaxis treatment practices over 10 years, covering several European regions, all allergen sources, and all age groups.

Methods: The European Anaphylaxis Register tracks elicitors, symptoms, emergency treatment, diagnostic workups, and long-term counseling for anaphylaxis incidents through web-based data entry from tertiary allergy specialists, covering information from the emergency respondent, patient, tertiary referral, and laboratory/clinical test results. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.02.026DOI Listing
March 2018
52 Reads

Anxiety, Depression, and Asthma Control: Changes After Standardized Treatment.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1953-1959. Epub 2018 Feb 15.

CIBERES, Instituto Carlos III, Madrid, Spain; Unit of Allergy and Asthma, Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health care resources, and poor asthma control.

Objective: To examine the association of asthma diagnosis with symptoms of depression/anxiety and asthma control not only at baseline but also over a 6-month period of specialist supervision.

Methods: We enrolled 3182 patients with moderate to severe asthma. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.02.002DOI Listing
February 2018
4 Reads

Use of ICS/LABA Combinations or LAMA Is Associated with a Lower Risk of Acute Exacerbation in Patients with Coexistent COPD and Asthma.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1927-1935.e3. Epub 2018 Feb 10.

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: Based on current guidelines, more research is urgently needed to guide appropriate treatment for patients with asthma-chronic obstructive pulmonary disease (COPD) overlap.

Objective: The objective of this study was to investigate medication effects on acute exacerbation in patients with coexistent COPD and asthma.

Methods: Using Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study to evaluate medication effects in patients with COPD and asthma. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.01.035DOI Listing
February 2018
8 Reads

Implementation of guidelines for early peanut introduction at a pediatric academic center.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1784-1786. Epub 2018 Feb 9.

Nationwide Children's Hospital, Division of Allergy and Immunology, The Ohio State University College of Medicine, Columbus, Ohio.

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http://dx.doi.org/10.1016/j.jaip.2018.01.036DOI Listing
February 2018
4 Reads

Value of a Second Dose of Epinephrine During Anaphylaxis: A Patient/Caregiver Survey.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1559-1567. Epub 2018 Feb 3.

Section of Allergy/Immunology, University of Tennessee College of Medicine, Memphis, Tenn.

Background: Anaphylaxis guidelines recommend prescription of more than 1 epinephrine autoinjector (EAI) for patients at risk. A second epinephrine dose is required in 16% to 36% of patients.

Objective: To evaluate real-world use of EAIs and understand the patients'/caregivers' adherence to guidelines. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.01.019DOI Listing
February 2018
4 Reads

Clinician Agreement, Self-Efficacy, and Adherence with the Guidelines for the Diagnosis and Management of Asthma.

J Allergy Clin Immunol Pract 2018 May - Jun;6(3):886-894.e4. Epub 2018 Feb 3.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

Background: The 2007 Guidelines for the Diagnosis and Management of Asthma provide evidence-based recommendations to improve asthma care. Limited national-level data are available about clinician agreement and adherence to these guidelines.

Objective: To assess clinician-reported adherence with specific guideline recommendations, as well as agreement with and self-efficacy to implement guidelines. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948143PMC
February 2018
13 Reads

Should Younger Siblings of Peanut Allergic Children Be Screened for Peanut Allergy?

J Allergy Clin Immunol Pract 2018 Mar - Apr;6(2):414-418. Epub 2018 Feb 1.

Department of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.

The role of screening younger siblings of peanut allergic children with allergy testing before peanut introduction is controversial. Although certain guidelines note some value in screening this population, it is not a direct indication in the recent National Institute of Allergy and Infectious Diseases guideline. Some studies suggest that siblings of peanut allergic children are at increased risk of peanut allergy, whereas others note that delayed ingestion or mislabeling of allergy in these children may be the main factors accounting for this increased risk. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.01.002DOI Listing
February 2018
3 Reads

Asthma and Allergic Disorders in Uganda: A Population-Based Study Across Urban and Rural Settings.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1580-1587.e2. Epub 2018 Feb 1.

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. Electronic address:

Background: Allergic diseases are increasing in sub-Saharan Africa, but few studies have characterized the burden among adults.

Objective: We conducted a study to evaluate the prevalence and risk factors of allergic disorders in urban and rural Uganda.

Methods: We present a cross-sectional analysis of enrollment data from a population-based cohort study of adults aged ≥35 years in urban and rural Uganda. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050146PMC
February 2018
11 Reads

Biologic Therapy for Atopic Dermatitis: Moving Beyond the Practice Parameter and Guidelines.

Authors:
Mark Boguniewicz

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1477-1487

Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver, Colo. Electronic address:

Atopic dermatitis (AD), a common chronic pruritic inflammatory skin disease, impacts the quality of life of patients and caregivers and has become a global health problem. It is increasingly recognized as a disease not only of children but also of adults who may have a persistent or relapsing course from childhood or who develop new-onset adult disease. Besides well-established atopic comorbidities, associations with a number of nonatopic comorbidities have been reported. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.08.031DOI Listing
June 2018
3 Reads

When Should Infants with Cow's Milk Protein Allergy Use an Amino Acid Formula? A Practical Guide.

J Allergy Clin Immunol Pract 2018 Mar - Apr;6(2):383-399. Epub 2017 Nov 3.

Section of Allergy and Immunology, Children's Hospital Colorado, University of Colorado, Denver, Colo.

Cow's milk protein allergy (CMPA) is the most common food allergy in childhood and its prevalence ranges between 1.9% and 4.9%. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.09.003DOI Listing
November 2017
7 Reads

Expert Perspectives on Management of Moderate-to-Severe Atopic Dermatitis: A Multidisciplinary Consensus Addressing Current and Emerging Therapies.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1519-1531. Epub 2017 Sep 29.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY.

Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects children and adults. Until recently, the only Food and Drug Administration-approved systemic treatment option for patients with moderate-to-severe AD was systemic steroids, which are not recommended by current guidelines and are commonly associated with disease rebound. Instead, clinicians choose from several off-label immunosuppressants, which can have serious adverse effects. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.08.005DOI Listing
June 2018
32 Reads

Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1280-1287.e2

Department of Allergy and Immunology, Heart of England NHS Foundation Trust, Birmingham, United Kingdom; Institute of Immunology & Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

Background: British guidelines recommend that serial acute serum tryptase measurements be checked in all adults and a subset of children presenting with anaphylaxis. This is the first study reporting the clinical utility of acute serum tryptase in a "real-world" emergency department (ED) setting following the publication of the World Allergy Organization (WAO) criteria for anaphylaxis.

Objectives: To (1) assess sensitivity, specificity, and positive and negative predictive values (PPV, NPV) of acute serum tryptase in anaphylaxis; (b) determine factors associated with higher acute serum tryptase levels; and (c) audit compliance of acute serum tryptase measurement in the ED. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198173050
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http://dx.doi.org/10.1016/j.jaip.2017.06.021DOI Listing
May 2018
41 Reads

Epinephrine Autoinjectors: New Data, New Problems.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1180-1191

Department of Pediatrics, Allergy Section, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colo.

Epinephrine is the first-line treatment for anaphylaxis. Despite this, there have been identified gaps in the management of anaphylaxis including infrequent or delayed use of epinephrine for acute allergic reactions, as well as inadequate epinephrine autoinjector (EAI) training, and prescription rates of these devices for patients at risk. This paper reviews new data, and new problems in recently published literature on EAIs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198173051
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http://dx.doi.org/10.1016/j.jaip.2017.06.027DOI Listing
May 2018
9 Reads

Reviewing the Content and Design of Anaphylaxis Management Plans Published in English.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1288-1294.e4. Epub 2017 Aug 3.

Division of Primary Care, Brighton & Sussex Medical School, Mayfield House, University of Brighton, Brighton, United Kingdom; Family Medicine and Primary Care, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Background: Guidelines recommend that patients at risk of anaphylaxis are given an anaphylaxis management plan (AMP) providing advice on symptom recognition and emergency management. However, the format and content of plans is not standardized.

Objective: The objective of this study was to review the design and contents of different AMPs available in English. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.06.032DOI Listing
May 2018
8 Reads

Temporal Trends in Epinephrine Dispensing and Allergy/Immunology Follow-up Among Emergency Department Anaphylaxis Patients in the United States, 2005-2014.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1272-1279.e1. Epub 2017 Jul 26.

Department of Emergency Medicine, Mayo Clinic, Rochester, Minn. Electronic address:

Background: Anaphylaxis is a potentially life-threatening allergic reaction; measures including prescription of an epinephrine autoinjector (EAI) and allergy/immunology (A/I) follow-up may prevent future morbidity.

Objective: The objective of this study was to evaluate trends in outpatient management of anaphylaxis by studying EAI dispensing and A/I follow-up among patients seen in the emergency department (ED) for anaphylaxis from 2005 through 2014.

Methods: We analyzed administrative claims data from the OptumLabs Data Warehouse database using an expanded International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code algorithm. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.06.009DOI Listing
May 2018
12 Reads

Evaluation of a Guidelines-Based Approach to the Treatment of Chronic Spontaneous Urticaria.

J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):177-182.e1. Epub 2017 Jul 12.

Group of Experimental and Clinical Allergy, IPS Universitaria, University of Antioquia, Medellín, Colombia.

Background: International scientific associations have made recommendations for the management of chronic spontaneous urticaria (CSU) that have been summarized in clinical guidelines.

Objective: To evaluate the clinical impact of guideline recommendations for CSU management.

Methods: A multicenter, triple-blinded, prospective, randomized study (the Urticaria Research of Tropical Impact and Control Assessment project; ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.06.002DOI Listing
July 2017
13 Reads

An Australian Consensus on Infant Feeding Guidelines to Prevent Food Allergy: Outcomes From the Australian Infant Feeding Summit.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1617-1624. Epub 2017 May 9.

Centre for Food and Allergy Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Allergy and Clinical Immunology, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom. Electronic address:

Background: Infant feeding in the first postnatal year of life has an important role in an infant's risk of developing food allergy. Consumer infant feeding advice is diverse and lacks consistency.

Aim: The Australian Infant Feeding Summit was held with the aim of achieving national consensus on the wording of guidelines for infant feeding and allergy prevention. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.03.013DOI Listing
June 2018
97 Reads

Positive Skin Test or Specific IgE to Penicillin Does Not Reliably Predict Penicillin Allergy.

J Allergy Clin Immunol Pract 2017 May - Jun;5(3):676-683

Odense Research Center for Anaphylaxis, Odense, Denmark; Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark.

Introduction: According to guidelines, patients are diagnosed with penicillin allergy if skin test (ST) result or specific IgE (s-IgE) to penicillin is positive. However, the true sensitivity and specificity of these tests are presently not known.

Objective: To investigate the clinical relevance of a positive ST result and positive s-IgE and to study the reproducibility of ST and s-IgE. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.03.014DOI Listing
February 2018
34 Reads

Oral Challenge without Skin Testing Safely Excludes Clinically Significant Delayed-Onset Penicillin Hypersensitivity.

J Allergy Clin Immunol Pract 2017 May - Jun;5(3):669-675

Allergy and Clinical Immunology Unit, Meir General Hospital, Kfar-Saba, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Penicillins are the drug family most commonly associated with hypersensitivity reactions. Current guidelines recommend negative skin tests (ST) before re-administering penicillins to patients with previous nonimmediate reactions (NIR).

Objective: The objective of this study was to examine whether ST are necessary before re-administering penicillin to patients with NIR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198173016
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http://dx.doi.org/10.1016/j.jaip.2017.02.023DOI Listing
February 2018
26 Reads

Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation.

J Allergy Clin Immunol Pract 2017 May - Jun;5(3):616-625.e7

Harvard Medical School, Boston, Mass; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

Addressing inaccurate penicillin allergies is encouraged as part of antibiotic stewardship in the inpatient setting. However, implementing interventions targeted at the 10% to 15% of inpatients reporting a previous penicillin allergy can pose substantial logistic challenges. We implemented a computerized guideline for patients with reported beta-lactam allergy at 5 hospitals within a single health care system in the Boston area. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484001PMC
February 2018
45 Reads

Radiographic Evidence of Sinonasal Inflammation in Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: An Underrecognized Association.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1657-1662. Epub 2017 Apr 29.

Department of Airway Medicine, Mitsubishi Kyoto Hospital, Kyoto, Japan.

Background: Sinonasal inflammation on both clinical examinations and imaging significantly impacts both asthma and chronic obstructive pulmonary disease (COPD).

Objective: The objective of this study was to examine the association between sinonasal inflammation and asthma-COPD overlap syndrome (ACOS).

Methods: A total of 112 patients with a ratio of forced expiratory volume in 1 s to forced vital capacity of less than 70% were enrolled. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.03.031DOI Listing
June 2018
5 Reads

Asthma Control and Sputum Eosinophils: A Longitudinal Study in Daily Practice.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1335-1343.e5. Epub 2017 Apr 25.

Department of Respiratory Medicine, GIGA I(3) Research Group, University of Liege, Liege, Belgium.

Background: Longitudinal trials have suggested that asthma control may be influenced by fluctuations in eosinophilic inflammation. This association has however never been confirmed in daily practice.

Objective: To investigate the relationship between asthma control and sputum eosinophils in clinical practice. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.01.026DOI Listing
May 2018
13 Reads

A Randomized Pragmatic Trial of Changing to and Stepping Down Fluticasone/Formoterol in Asthma.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1378-1387.e5. Epub 2017 Mar 25.

Research in Real Life Ltd, Cambridge, United Kingdom; Academic Primary Care, University of Aberdeen, Aberdeen, United Kingdom; Observational and Pragmatic Research Institute, Singapore. Electronic address:

Background: Guidelines recommend reducing treatment in patients with well-controlled asthma after 3 months of stability. However, there is inadequate real-life data to guide physicians on therapy change in daily practice.

Objective: To assess asthma control after change to and step-down of fluticasone propionate/formoterol fumarate dihydrate (FP/FOR) in real-life patients. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.02.006DOI Listing
May 2018
20 Reads

Comparison of Pediatric and Adult Systemic Reactions to Subcutaneous Immunotherapy.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1241-1247.e2. Epub 2017 Mar 21.

Division of Allergy and Immunology, Hofstra Northwell School of Medicine, Great Neck, NY. Electronic address:

Background: Subcutaneous immunotherapy (SCIT) has been used to treat allergic rhinitis for over a century, and current regimens have wide variability with an array of practice styles and dosing strategies. Although there are some statements about contraindications and cautions, no specific formal age- or weight-based dosing guidelines are utilized when administering SCIT.

Objective: The primary objective of this study was to estimate the overall incidence rate of any reaction to SCIT and to consider the severity of the reaction by grade in children and adults. Read More

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http://dx.doi.org/10.1016/j.jaip.2017.01.014DOI Listing
May 2018
22 Reads

Trends in Provider Management of Patients with Food Protein-Induced Enterocolitis Syndrome.

J Allergy Clin Immunol Pract 2017 Sep - Oct;5(5):1319-1324.e12. Epub 2017 Mar 9.

Icahn School of Medicine at Mount Sinai, New York, NY; Jaffe Family Food Allergy Institute, New York, NY.

Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy.

Objective: To better understand provider-level variation in FPIES knowledge and management.

Methods: A 23-question online survey was administered to AAAAI members during the spring and summer of 2014. Read More

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http://dx.doi.org/10.1016/j.jaip.2016.11.036DOI Listing
May 2018
6 Reads

AAAAI/ACAAI Joint Venom Extract Shortage Task Force Report.

J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):330-332

Allergy, Asthma & Sinus, George Washington Medical Center, Rockville, Md.

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http://dx.doi.org/10.1016/j.jaip.2017.02.005DOI Listing
January 2019
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Dietary Therapy and Nutrition Management of Eosinophilic Esophagitis: A Work Group Report of the American Academy of Allergy, Asthma, and Immunology.

J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):312-324.e29

Departments of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

Eosinophilic esophagitis (EoE) is a chronic/immune-antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Dietary elimination therapy has been shown to be an effective, drug-free prescription for the treatment of EoE. A range of different dietary elimination therapies have been used. Read More

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http://dx.doi.org/10.1016/j.jaip.2016.12.026DOI Listing
November 2017
26 Reads

Food Allergy: Unmet Needs and New Perspectives.

J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):295

Department of Paediatric Allergy, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.jaip.2017.01.002DOI Listing
January 2019
1 Read