2,287,972 results match your criteria Growth factors Chur Switzerland[Journal]


[Activation of GPER inhibts proliferation and autophagy in prostatic epithelial cells].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):419-422

Department of Urology, the First Affiliated Hospital of Guangzhou Medical College, Guangdong Key Laboratory of Urology, Guangzhou 510230, China.

To investigate the effect of G protein-coupled estrogen receptor (GPER) on proliferation and autophagy in prostatic epithelial cells. Cell Counting Kit-8 (CCK8) assay was used to observe the growth of BPH-1 and RWPE-1 cells after treating with or not with estradiol or GPER selective agonist G1. Autophagy was quantified with Western blot and Cyto-ID autophagy detection kit after treating with estradiol, G1 or both G1 and G15 in the same cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.007DOI Listing
February 2019

Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells.

Dev Growth Differ 2019 Feb 20. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatic progenitor cells (HPCs) in adult liver are promising for treatment of liver diseases. A biliary-derived HPC population in adult mice has been characterized by co-expression of stem cell marker Sry (sex determining region Y)-box 9 (SOX9) and biliary marker cytokeratin 7 (CK7). However, isolation of these HPCs in adult healthy liver without any selection procedures remains a big challenge in this field. Read More

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http://dx.doi.org/10.1111/dgd.12596DOI Listing
February 2019

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):661-676

BioSciences Department, Rice University, Houston, Texas, United States.

Purpose: Defects in neural crest development are a major contributing factor in corneal dysgenesis, but little is known about the genetic landscape during corneal development. The purpose of this study was to provide a detailed transcriptome profile and evaluate changes in gene expression during mouse corneal development.

Methods: RNA sequencing was used to uncover the transcriptomic profile of periocular mesenchyme (pNC) isolated at embryonic day (E) 10. Read More

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http://dx.doi.org/10.1167/iovs.18-26018DOI Listing
February 2019

3D bioprinted complex constructs reinforced by hybrid multilayers of electrospun nanofiber sheets.

Biofabrication 2019 Feb 20. Epub 2019 Feb 20.

Digital Manufacturing Process Group, Korea Institute of Industrial Technology, Siheung-si, KOREA, REPUBLIC OF.

Despite the usefulness of hydrogels for cell-based bioprinting, the fragility of their resulting constructs has hindered their practical applications in tissue engineering research. Here, we suggest a hybrid integration method based on cell-hydrogel bioprinting that includes alternate layering of flexible nanofiber sheets. Because the bioprinting was implemented on a nanofibrous surface, the hydrogel-based materials could be printed with enhanced shape resolution compared to printing on a bare hydrogel. Read More

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http://dx.doi.org/10.1088/1758-5090/ab08c2DOI Listing
February 2019

Thickness Tunable Wedding-Cake Like MoS Flakes for High Performance Optoelectronics.

ACS Nano 2019 Feb 20. Epub 2019 Feb 20.

Atomically thin transition metal dichalcogenides (TMDCs) have received substantial interests due to their unique thickness-dependent optical and electronic properties, and related applications in optoelectronics. However, the large-scale, thickness tunable growth of such materials are still challenging. Herein, we report a fast growth of thickness tunable wedding-cake like MoS flakes on 6-inch soda-lime glass, by using NaCl-coated Mo foils as metal-precursors. Read More

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http://dx.doi.org/10.1021/acsnano.9b00277DOI Listing
February 2019

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing.

Small 2019 Feb 20:e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

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http://dx.doi.org/10.1002/smll.201900046DOI Listing
February 2019

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

J Bone Miner Res 2019 Feb 20:e3646. Epub 2019 Feb 20.

Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.

Embryonic growth and bone development depend on placental Ca transport across the feto-maternal barrier to supply minerals to the fetus. The individual factors and cellular mechanisms that regulate placental Ca transfer, however, are only beginning to emerge. We find that the Ca -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of the fetal labyrinth, in the yolk sac, and in the maternal part of the placenta. Read More

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http://dx.doi.org/10.1002/jbmr.3646DOI Listing
February 2019

Combination of phytase and citric acid, but not phytase alone, ensures regular rates of growth and bone mineralization in quails under severe phosphorus restriction.

J Anim Physiol Anim Nutr (Berl) 2019 Feb 20. Epub 2019 Feb 20.

College of Veterinary Medicine, Federal University of Mato Grosso, Cuiaba, Brazil.

An experiment was conducted to evaluate the effects of phytase (PHY), alone or in combination with citric acid (CA), on growing Japanese quails under moderate and severe phosphorus (P) restriction. For this, 504 one-day-old female quails were distributed in a completely randomised design with seven treatments and six replications. Treatments consisted of the following diets: (a) positive control (PC): formulated according to quails nutritional requirements; (b) negative control 40% (NC ): PC with 40% less aP; (c) NC +PHY; (d) NC +PHY+CA; (e) negative control 65% (NC ): PC with 65% less aP; (f) NC +PHY; (g) NC +PHY+CA. Read More

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http://dx.doi.org/10.1111/jpn.13074DOI Listing
February 2019

Growth, Challenges and Opportunities in Indian Nursing.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

College of Nursing, Bharati Vidyapeeth Deemed University, Pune, India.

In India, nurses and midwives make up more than 30% of the national healthcare workforce (World Health Organisation, 2016). The country has also witnessed a phenomenal growth in the uptake of nursing education with an increase during the last eight years of Graduate nursing schools; 285 to 3215, BSc colleges; 30 to 1936, and MSc nursing colleges; 10 to 643 (Indian Nursing Council, 2019). Many of the BSc and MSc colleges are now moving to health universities and deemed institutes. Read More

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http://dx.doi.org/10.1111/jan.13978DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

Berberine attenuates hypoxia-induced pulmonary arterial hypertension via bone morphogenetic protein and transforming growth factor-β signaling.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Hypoxia-induced excessive pulmonary artery smooth muscle cell (PASMC) proliferation plays an important role in the pathology of pulmonary arterial hypertension (PAH). Berberine (BBR) is reported as an effective antiproliferative properties applied in clinical. However, the effect of BBR on PAH remains unclear. Read More

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http://dx.doi.org/10.1002/jcp.28370DOI Listing
February 2019

[Sustainable development goals and mental health].

Vertex 2018 Nov;XXIX(142):300-303

Centre for Global Mental Health, King's College London, Institute of Psychiatry.

In 2015, the United Nations Sustainable Development Goals (SDGs) set the course for a more equitable distribution of resources globally. For the first time in history, this collective global commitment explicitly included mental health-related objectives, and manifested them as targets in the health SDG 3. This represents a unique opportunity to increase coverage and quality of services, especially in low- and middle-income countries, in which the current treatment gap surpasses 80% even for the most severe disorders. Read More

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November 2018

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

Analysis of development and evolution rules of civil aviation in China based on life cycle theory.

PLoS One 2019 20;14(2):e0212338. Epub 2019 Feb 20.

National Key Laboratory of ATC Safety Technology, Civil Aviation University of China, Tianjin, China.

The development of CAAC began in the early days of 1949. From a comparatively less popular means of transport to the world's second largest by volume, this means of transport has undergone major and minor changes in the last 70 years. It is not known whether there are significant laws in the process of development. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212338PLOS
February 2019

Identifying developmental trajectories of worldwide road traffic accident death rates using a latent growth mixture modeling approach.

PLoS One 2019 20;14(2):e0212402. Epub 2019 Feb 20.

Department of Foreign Languages, Iran University of Medical Sciences, Tehran, Iran.

Road Traffic Accidents (RTA) are a major worldwide public health problem. The aim of this study was to use the growth mixture model for clustering countries on the basis of the mortality rate patterns of RTAs from 2007 to 2013. We obtained the data on RTA death rates from World Health Organization reports and Human Development Index (HDI) of United Nations Development Programme reports for the years 2007, 2010 and 2013. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212402PLOS
February 2019

Treatment cure rate and its predictors among children with severe acute malnutrition in northwest Ethiopia: A retrospective record review.

PLoS One 2019 20;14(2):e0211628. Epub 2019 Feb 20.

Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Background: More than 29 million that is an estimated 5%, under-five children suffer from severe acute malnutrition (SAM) globally, with a nine times higher risk of mortality than that of well-nourished children. However, little is known regarding outcomes and predictors of SAM in Ethiopia. Therefore, this study aims to determine treatment cure rate and its predictors among children aged 6-59 months with SAM admitted to a stabilization center. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211628PLOS
February 2019

Access to and price trends of antidiabetic, antihypertensive, and antilipidemic drugs in outpatient settings of the Universal Coverage Scheme in Thailand.

PLoS One 2019 20;14(2):e0211759. Epub 2019 Feb 20.

Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand.

Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211759PLOS
February 2019

Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.

PLoS One 2019 20;14(2):e0211436. Epub 2019 Feb 20.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Gliadin, a component of wheat gluten known to be an important factor in the etiology of celiac disease, is related to several other diseases through its enhancing effect on intestinal paracellular permeability. We investigated the significance of gliadin in non-steroidal anti-inflammatory drug (NSAID)-induced small-intestinal damage in mice. 7-week-old C57BL/6 male mice were divided into the following groups: standard diet group, in which mice were fed with wheat-containing standard rodent diet (CE-2); gluten-free diet group, in which mice were fed with gluten-free diet (AIN-76A); and gliadin-administered group, in which mice fed with gluten-free diet were administered with gliadin (~250 mg/kg BW). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211436PLOS
February 2019

Liver metastasis and Heng risk are prognostic factors in patients with non-nephrectomized synchronous metastatic renal cell carcinoma treated with systemic therapy.

PLoS One 2019 20;14(2):e0211105. Epub 2019 Feb 20.

Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea.

Objective: This study aimed to determine the prognostic factors of progression-free survival (PFS) and overall survival (OS) in non-nephrectomized patients with synchronous metastatic renal cell carcinoma (mRCC) receiving first-line vascular endothelial growth factor (VEGF)-targeted therapy or immunotherapy.

Methods: Of 70 patients, 57 (81.4%) were treated with targeted therapy, including 5 (7. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211105PLOS
February 2019

Moderate plant water stress improves larval development, and impacts immunity and gut microbiota of a specialist herbivore.

PLoS One 2019 20;14(2):e0204292. Epub 2019 Feb 20.

Organismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki, Finland.

While host plant drought is generally viewed as a negative phenomenon, its impact on insect herbivores can vary largely depending on the species involved and on the intensity of the drought. Extreme drought killing host plants can clearly reduce herbivore fitness, but the impact of moderate host plant water stress on insect herbivores can vary, and may even be beneficial. The populations of the Finnish Glanville fritillary butterfly (Melitaea cinxia) have faced reduced precipitation in recent years, with impacts even on population dynamics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204292PLOS
February 2019

Isoform-specific Ras signaling is growth factor dependent.

Mol Biol Cell 2019 Feb 20:mbcE18100676. Epub 2019 Feb 20.

Division of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, L69 3BX, UK.

HRAS, NRAS and KRAS isoforms are almost identical proteins that are ubiquitously expressed and activate a common set of effectors. In vivo studies have revealed that they are not biologically redundant; however, the isoform-specificity of Ras signaling remains poorly understood. Using a novel panel of isogenic SW48 cell lines endogenously expressing wild type or G12V mutated activated Ras isoforms we have performed a detailed characterization of endogenous isoform-specific mutant Ras signaling. Read More

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http://dx.doi.org/10.1091/mbc.E18-10-0676DOI Listing
February 2019

Myosin IIA drives membrane bleb retraction.

Mol Biol Cell 2019 Feb 20:mbcE18110752. Epub 2019 Feb 20.

Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Membrane blebs are specialized cellular protrusions that play diverse roles in processes such as cell division and cell migration. Blebbing can be divided into three distinct phases- bleb nucleation, bleb growth and bleb retraction. Following nucleation and bleb growth, the actin cortex, comprising actin, cross-linking proteins and non-muscle myosin II (MII), begins to re-assemble on the membrane. Read More

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http://dx.doi.org/10.1091/mbc.E18-11-0752DOI Listing
February 2019

National Health Expenditure Projections, 2018-27: Economic And Demographic Trends Drive Spending And Enrollment Growth.

Health Aff (Millwood) 2019 Feb 20:101377hlthaff201805499. Epub 2019 Feb 20.

James C. Hardesty is an actuary in the CMS Office of the Actuary.

National health expenditures are projected to grow at an average annual rate of 5.5 percent for 2018-27 and represent 19.4 percent of gross domestic product in 2027. Read More

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http://dx.doi.org/10.1377/hlthaff.2018.05499DOI Listing
February 2019

West German Study PlanB Trial: Adjuvant Four Cycles of Epirubicin and Cyclophosphamide Plus Docetaxel Versus Six Cycles of Docetaxel and Cyclophosphamide in HER2-Negative Early Breast Cancer.

J Clin Oncol 2019 Feb 20:JCO1800028. Epub 2019 Feb 20.

1 West German Study Group, Mönchengladbach, Germany.

Purpose: The West German Study Group PlanB trial evaluated an anthracycline-free chemotherapy standard (six cycles of docetaxel and cyclophosphamide [TC]) in the routine treatment of human epidermal growth factor receptor 2-negative early breast cancer (EBC).

Patients And Methods: Patients with pT1 to pT4c, all pN+, and pN0/high-risk EBC were eligible. High-risk pN0 was defined by one or more of the following: pT greater than 2, grade 2 to 3, high urokinase-type plasminogen activator/plasminogen activator inhibitor-1, hormone receptor (HR) negativity, and less than 35 years of age. Read More

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http://dx.doi.org/10.1200/JCO.18.00028DOI Listing
February 2019

The Role of 5-aza-2'-Deoxycytidine on Methylation Status of Xist Gene in Different Genders of Buffalo (Bubalus bubalis) Bone Marrow Mesenchymal Stem Cells.

Cell Reprogram 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Animal Reproduction Institute, Guangxi University, Nanning, China.

Previous studies have demonstrated that proper concentration of 5-aza-2'-deoxycytidine (5-aza-CdR) treatment was advantageous to decrease DNA methylation level, but the relationships between 5-aza-CdR treatment and methylation status of imprinted genes are seldom detected. The aim of this study was to investigate the effect of low concentration 5-aza-CdR treatment on the methylation status of imprinted gene Xist in different genders of buffalo bone marrow mesenchymal stem cells (BMSCs). BMSCs were isolated and the cell gender was identified through polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1089/cell.2018.0040DOI Listing
February 2019

Spatial mapping of local density variations in two-dimensional electron systems using scanning photoluminescence.

Nano Lett 2019 Feb 20. Epub 2019 Feb 20.

We have developed a scanning photoluminescence technique that can directly map out the local two-dimensional electron densities with a relative accuracy of ~2.2×10 cm. The validity of this approach is confirmed by the observation of the expected density gradient in a high-quality GaAs quantum well sample that was not rotated during the molecular beam epitaxy of its spacer layer. Read More

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http://dx.doi.org/10.1021/acs.nanolett.8b05047DOI Listing
February 2019

New β-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-derived Fungus MCCC3A00957.

J Agric Food Chem 2019 Feb 20. Epub 2019 Feb 20.

Fusarium solani H915 (MCCC3A00957), a fungus originating from mangrove sediment, showed potent inhibitory activity against tea pathogenic fungus Pestalotiopsis theae. Successive chromatographic separation on an ethyl acetate (EtOAc) extract of F. solani H915 resulted in the isolation of five new alkenoic diacid derivatives, fusarilactones A-C (1-3), fusaridioic acids B (4) and C (5), in addition to seven known compounds (6-12). Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00228DOI Listing
February 2019

Atomistic Origin of the Complex Morphological Evolution of Aluminum Nanoparticles during Oxidation: a Chain-Like Oxide Nucleation and Growth Mechanism.

ACS Nano 2019 Feb 20. Epub 2019 Feb 20.

Metal nanoparticles usually show different oxidation dynamics from bulk metals, which results in various oxide nanostructures because of their size-related surface effects. In this work, we have found and investigated the chain-like nucleation and growth of oxides on the Aluminum nanoparticle (ANP) surface, using molecular dynamics simulations with the reactive force-field (ReaxFF). After nucleation, the chain-like oxide nuclei could stay on the ANP surface and continue growing into an oxide shell, or extend outward from the surface to form longer oxide chains, or detach from the ANP to generate independent oxide clusters, which is highly dependent on the oxygen content, temperature and nanoparticle size. Read More

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http://dx.doi.org/10.1021/acsnano.8b07633DOI Listing
February 2019

Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii.

ACS Chem Biol 2019 Feb 20. Epub 2019 Feb 20.

Environmental and pathogenic microbes produce siderophores as small iron-binding molecules to scavenge iron from natural environments. It is common for microbes to produce multiple siderophores to gain a competitive edge in mixed microbial environments. Strains of human pathogenic Acinetobacter baumannii produce up to three siderophores: acinetobactin, baumannoferrin, and fimsbactin. Read More

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http://dx.doi.org/10.1021/acschembio.8b01051DOI Listing
February 2019

Limited significance of repeated long-term radiological and hormonal examination in nonfunctioning adrenal incidentalomas.

Int Braz J Urol 2018 Dec 18;44. Epub 2018 Dec 18.

Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Purpose: The purposes of the present study were to evaluate growth rate of nonfunctioning adrenal incidentalomas (AIs) and their development to hormonal hypersecretion on follow-up.

Materials And Methods: A retrospective study was conducted from the electronic medical records. A total of 314 patients were diagnosed with adrenal tumors between 2000 and 2016. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0235DOI Listing
December 2018

[Possibilities of application of the liquid transport medium for capture of pathological material at laboratory diagnosis of a diphtheria infection.]

Klin Lab Diagn 2018 ;63(12):783-787

«Galen», 125373, Moscow, Russian Federation.

The main objective of laboratory diagnosis of a diphtheria is identification of the causative agent by means of the minimum quantity of diagnostic tests for obtaining the authentic answer in the most short time. One of the major stages is capture and delivery of pathological material on which the efficiency of carrying out and timeliness of issue of the final answer depends. Considering emergence in the market of commercial liquid transport mediums, assessment of their efficiency for diagnosis of diphtheria is advisable. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-783-787DOI Listing
January 2018

Edge Segregated Polymorphism in 2D Molybdenum Carbide.

Adv Mater 2019 Feb 20:e1808343. Epub 2019 Feb 20.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 17543, Singapore.

Molybdenum carbide (Mo C), a class of unterminated MXene, is endowed with rich polymorph chemistry, but the growth conditions of the various polymorphs are not understood. Other than the most commonly observed T-phase Mo C, little is known about other phases. Here, Mo C crystals are successfully grown consisting of mixed polymorphs and polytypes via a diffusion-mediated mechanism, using liquid copper as the diffusion barrier between the elemental precursors of Mo and C. Read More

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http://dx.doi.org/10.1002/adma.201808343DOI Listing
February 2019

Efficacy and Posttreatment Effects of Therapist-Delivered Cognitive Behavioral Therapy vs Supportive Psychotherapy for Adults With Body Dysmorphic Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

Importance: Cognitive behavioral therapy (CBT), the best-studied treatment for body dysmorphic disorder (BDD), has to date not been compared with therapist-delivered supportive psychotherapy, the most commonly received psychosocial treatment for BDD.

Objective: To determine whether CBT for BDD (CBT-BDD) is superior to supportive psychotherapy in reducing BDD symptom severity and associated BDD-related insight, depressive symptoms, functional impairment, and quality of life, and whether these effects are durable.

Design, Setting, And Participants: This randomized clinical trial conducted at Massachusetts General Hospital and Rhode Island Hospital recruited adults with BDD between October 24, 2011, and July 7, 2016. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.4156DOI Listing
February 2019

Glucose causes primary necrosis in exponentially grown yeast saccharomyces cerevisiae.

FEMS Yeast Res 2019 Feb 20. Epub 2019 Feb 20.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, FRC PCBR RAS.

In this paper we present data on sugar-induced cell death (SICD) in the yeast S.cerevisiae in the exponential phase of growth. We suggest that the nature of SICD in exponentially grown yeast is primary necrosis, in contrast to cells in the stationary growth phase, which exhibit apoptotic SICD. Read More

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http://dx.doi.org/10.1093/femsyr/foz019DOI Listing
February 2019

Experimental and modeling evidence of carbon limitation of leaf appearance rate for spring and winter wheat.

J Exp Bot 2019 Feb 20. Epub 2019 Feb 20.

LEPSE, Université Montpellier, INRA, Montpellier SupAgro, Montpellier, France.

Accurate predictions of the timing of physiological stages and the development rate are crucial for predicting crop performance under field conditions. Plant development is controlled by the leaf appearance rate (LAR) and our understanding of how LAR responds to environmental factors is still limited. Here, we tested the hypothesis that carbon availability may account for the effects of irradiance, photoperiod, atmospheric CO2 concentration, and ontogeny on LAR. Read More

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http://dx.doi.org/10.1093/jxb/erz012DOI Listing
February 2019

Prognostic factors for response to chemotherapy in advanced tumors of the uterine cervix: the role of neoangiogenesis.

Rev Col Bras Cir 2019 Feb 18;46(1):e2077. Epub 2019 Feb 18.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Ginecologia, Ribeirão Preto, SP, Brasil.

Objective: to analyze the expression of Vascular Endothelial Growth Factor (VEGF), its receptor (VEGFR-2), age and histological type of advanced cervical carcinomas with respect to the clinical response to neoadjuvant chemotherapy.

Methods: we studied 40 patients with cervical carcinoma (IB2 and IVA) diagnosed by biopsies prior to treatment. All patients underwent neoadjuvant chemotherapy and evaluation for clinical response and expression of VEGF. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192077DOI Listing
February 2019

FOOD INTAKE, NUTRITIONAL STATUS AND GASTROINTESTINAL SYMPTOMS IN CHILDREN WITH CEREBRAL PALSY.

Arq Gastroenterol 2018 Oct-Dec;55(4):352-357

Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Gastroenterologia Pediátrica, São Paulo, SP, Brasil.

Background: Cerebral palsy may be associated with comorbidities such as undernutrition, impaired growth and gastrointestinal symptoms. Children with cerebral palsy exhibit eating problems due to the effect on the anatomical and functional structures involved in the eating function resulting in malnutrition.

Objective: The aim of this study was to investigate the association between food intake, nutritional status and gastrointestinal symptoms in children with cerebral palsy. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-78DOI Listing

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000007. Epub 2019 Feb 14.

Master, Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. Acquisition of data.

Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000007DOI Listing
February 2019

Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity.

Braz J Med Biol Res 2019 Feb 14;52(2):e7988. Epub 2019 Feb 14.

Neuroscience Division, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra", Col. Arenal de Guadalupe, Delegacion Tlalpan, Mexico City, Mexico.

Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments. We evaluated the effect of serotonin on the extent of neuritic outgrowth and morphology of three different neuronal types in the leech Haementeria officinalis during their regeneration in vitro: Retzius interneurons (Rz), annulus erector (AE) motoneurons, and anterolateral number 1 (AL1) CNS neurons. Read More

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http://dx.doi.org/10.1590/1414-431X20187988DOI Listing
February 2019

Tuning bimetallic catalysts for a selective growth of SWCNTs.

Nanoscale 2019 Feb 20. Epub 2019 Feb 20.

Laboratoire de Physique des Interfaces et des Couches Minces, CNRS, Ecole Polytechnique, 91128, Palaiseau Cedex, France.

Recent advances in structural control during the synthesis of SWCNTs have in common the use of bimetallic nanoparticles as catalysts, despite the fact that their exact role is not fully understood. We therefore analyze the effect of the catalyst's chemical composition on the structure of the resulting SWCNTs by comparing three bimetallic catalysts (FeRu, CoRu and NiRu). A specific synthesis protocol is designed to impede the catalyst nanoparticle coalescence mechanisms and stabilize their diameter distributions throughout the growth. Read More

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http://dx.doi.org/10.1039/c8nr09589bDOI Listing
February 2019

Comparative genomics and transcriptomics insights into the C1 metabolic model of a formaldehyde-degrading strain Methylobacterium sp. XJLW.

Mol Omics 2019 Feb 20. Epub 2019 Feb 20.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China.

A formaldehyde-degrading strain Methylobacterium sp. XJLW was isolated and exhibited a special phenotype for formaldehyde utilization. The accumulation of formic acid in large quantities and lower cell growth was detected when XJLW utilized formaldehyde as the sole carbon source, suggesting XJLW has a potentially novel pathway to transfer formaldehyde to methanol and then enter the serine cycle for C1 metabolism. Read More

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http://dx.doi.org/10.1039/c8mo00198gDOI Listing
February 2019

Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, United States.

Much of the vertebrate skeleton develops from cartilage templates that are progressively remodeled into bone. Lineage tracing studies in mouse suggest that chondrocytes within these templates persist and become osteoblasts, yet the underlying mechanisms of this process and whether chondrocytes can generate other derivatives remain unclear. We find that zebrafish cartilages undergo extensive remodeling and vascularization during juvenile stages to generate fat-filled bones. Read More

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http://dx.doi.org/10.7554/eLife.42736DOI Listing
February 2019

Altererythrobacter amylolyticus sp. nov., isolated from lake sediment.

Int J Syst Evol Microbiol 2019 Feb 20. Epub 2019 Feb 20.

1​College of Biological Engineering, Henan University of Technology, Zhengzhou 450000, PR China.

An aerobic, motile, Gram-stain-negative bacterium, designated strain NS1, was isolated from interfacial sediment from Taihu Lake, China. The strain formed yellow colonies on R2A medium. Cells were ovoid to rod-shaped and non-spore-forming. Read More

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http://dx.doi.org/10.1099/ijsem.0.003299DOI Listing
February 2019

Sinorhodobacter populi sp. nov., isolated from the symptomatic bark tissue of Populus × euramericana canker.

Int J Syst Evol Microbiol 2019 Feb 20. Epub 2019 Feb 20.

1​The Key Laboratory of State Forestry Administration on Forest Protection, Research Institute of Forest Ecology Environment and Protection, Chinese Academy of Forestry, Beijing 100091, PR China.

We isolated five novel bacterial strains from symptomatic bark tissue of Populus × euramericana canker that were Gram-stain-negative, non-motile, aerobic oxidase-negative and catalase-positive. Growth occurred at 10-41 °C and at pH 5.0-7. Read More

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http://dx.doi.org/10.1099/ijsem.0.003300DOI Listing
February 2019

Proposal of Parashewanella gen. nov. to accommodate Parashewanella curva sp. nov. and Parashewanella spongiae comb. nov. in the Shewanellaceae.

Int J Syst Evol Microbiol 2019 Feb 20. Epub 2019 Feb 20.

1​Guangxi Key Laboratory on the Study of Coral Reefs in the South China Sea, Nanning 530004, PR China.

A Gram-stain-negative, non-spore-forming, motile, aerobic, curved rod shaped bacterium, designed strain C51, was isolated from coral (genus Porites) sampled at Weizhou Island, China. The optimal growth occurred in 2-3 % NaCl (w/v), at 25 °C and pH 8. Phylogenetic analyses based on the 16S rRNA gene, the gyrB gene and the Up-to-date Bacterial Core Gene set (92 genes) indicated that strain C51 forms a stable cluster with Shewanella spongiae KCTC 22492, and had 94 % 16S rRNA gene similarity to its closest type strain S. Read More

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http://dx.doi.org/10.1099/ijsem.0.003298DOI Listing
February 2019

Risk factors for development of obesity in an ethnically diverse CHD population.

Cardiol Young 2019 Feb;29(2):123-127

2Department of Pediatrics,Icahn School of Medicine at Mount Sinai,New York,NY,USA.

Objectives: Previous cross-sectional studies have demonstrated obesity rates in children with CHD and the general paediatric population. We reviewed longitudinal data to identify factors predisposing to the development of obesity in children, hypothesising that age may be an important risk factor for body mass index growth.Study designRetrospective electronic health records were reviewed in all 5-20-year-old CHD patients seen between 2011 and 2015, and in age-, sex-, and race/ethnicity-matched controls. Read More

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http://dx.doi.org/10.1017/S1047951118001889DOI Listing
February 2019

Update and future perspective of behavioral medicine in the treatment for chronic pain.

Pain Manag 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, University of California Irvine, CA 92868, USA 92868.

Chronic pain is a biopsychosocial condition, and behavioral medicine has made significant contributions to the understanding of the phenomenon and optimization of therapeutic outcomes. The objective of this article is to provide future perspectives of behavioral medicine in pain management based upon recent development in the field. We will briefly review the mainstream approach of cognitive-behavioral therapy, its variations and new and innovative approaches that are on the horizon. Read More

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http://dx.doi.org/10.2217/pmt-2017-0055DOI Listing
February 2019

Erythropoietin inhalation enhances adult canine alveolar capillary formation following pneumonectomy.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Internal Medicine, University of Texas Southwestern Medical Center, United States.

Paracrine erythropoietin (EPO) signaling in the lung recruits endothelial progenitor cells, promotes cell maturation and angiogenesis , and is upregulated during canine post-pneumonectomy (PNX) compensatory lung growth. To determine whether inhalational delivery of exogenous EPO augments endogenous post-PNX lung growth, adult canines underwent right PNX and received, via a permanent tracheal stoma, weekly nebulization of recombinant human EPO-containing nanoparticles or empty nanoparticles (control) for 16 weeks. Lung function was assessed under anesthesia pre- and post-PNX. Read More

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http://dx.doi.org/10.1152/ajplung.00504.2018DOI Listing
February 2019
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