2,308,663 results match your criteria Growth factors Chur Switzerland[Journal]


The role of academic mentors for Latino/a adolescents exposed to community violence.

J Community Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Aims: We examined the protective role of academic mentors for Latino/a youth exposed to community violence. We tested whether the mentor facilitation of positive growth and mentor school involvement moderated the relations between exposure to violence and Latino/a youth's educational values, school effort, and academic efficacy.

Methods: We used hierarchical linear regressions to examine these relations among 210 Latino/a high school students. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcop.22189
Publisher Site
http://dx.doi.org/10.1002/jcop.22189DOI Listing
April 2019
1 Read

Role of Nodal signalling in testis development and initiation of testicular cancer.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

A Jorgensen, Department of Growth and Reproduction, Rigshospitalet, Kobenhavn, Denmark.

Testicular development from the initially bipotential gonad is a tightly regulated process involving a complex signalling cascade to ensure proper sequential expression of signalling factors and secretion of steroid hormones. Initially, Sertoli cell specification facilitates differentiation of the steroidogenic fetal Leydig cells and establishment of the somatic niche, which is critical in supporting the germ cell population. Impairment of the somatic niche during fetal life may lead to development of male reproductive disorders, including arrest of gonocyte differentiation, which is considered the first step in the testicular cancer pathogenesis. Read More

View Article

Download full-text PDF

Source
https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
Publisher Site
http://dx.doi.org/10.1530/REP-18-0641DOI Listing
April 2019
1 Read

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

View Article

Download full-text PDF

Source
https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
1 Read
4.805 Impact Factor

Inorganic soil amendments alter seedling performance of native plant species in post-mining arid zone rehabilitation.

J Environ Manage 2019 Apr 15;241:179-186. Epub 2019 Apr 15.

The University of Western Australia, School of Biological Sciences, Crawley, 6009, WA, Australia; (b)Kings Park Science, Department of Biodiversity, Conservation and Attractions, Kings Park, 6005, WA, Australia; The University of New South Wales, Centre for Ecosystem Science, School of Biological, Earth and Environmental Sciences, Randwick, 2052, NSW, Australia.

Rehabilitation of degraded drylands is challenged by environmental and anthropogenic constraints, such as limited availability of locally-sourced topsoil and poor quality alternative soil substrates. Current rehabilitation practices, at times, utilise inorganic soil amendments to improve the physicochemical and biological characteristics of reconstructed soil profiles. These approaches may be appropriate for dryland rehabilitation, but there is limited research available regarding the benefits of using these amendments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.04.022DOI Listing

Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli.

Comput Biol Chem 2019 Mar 29;80:225-233. Epub 2019 Mar 29.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: The recombinant human truncated Keratinocyte growth factor (Palifermin) is the only FDA approved medicine for the treatment of oral mucositis. The Keratinocyte growth factor is a fairly unstable protein due to its high aggregation propensity and therefore its expression as a secretory protein may results in the production of a protein with more stability, higher solubility, better folding, enhanced biological activity, N-terminal authenticity and simplified downstream processing.

Objective: The aim of this study was in silico evaluation of 31 different secretory signal peptides to determine the best theoretical candidates for the secretory production of recombinant truncated human KGF in E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiolchem.2019.03.003DOI Listing

Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines.

Bioorg Chem 2019 Apr 11;88:102918. Epub 2019 Apr 11.

Department of Chemistry, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway. Electronic address:

The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines, and show that when employing (S)-phenylglycinol as C-4 substituent, potent inhibitors can be made. The two most active inhibitors have suitable druglike properties, were equipotent with Erlotinib in Ba/F3 cell studies, and showed lower cross reactivity than Erlotinib in a panel of 50 kinases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2019.102918DOI Listing

Computational approaches to macromolecular interactions in the cell.

Curr Opin Struct Biol 2019 Apr 15;55:59-65. Epub 2019 Apr 15.

Computational Biology Program and Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA. Electronic address:

Structural modeling of a cell is an evolving strategic direction in computational structural biology. It takes advantage of new powerful modeling techniques, deeper understanding of fundamental principles of molecular structure and assembly, and rapid growth of the amount of structural data generated by experimental techniques. Key modeling approaches to principal types of macromolecular assemblies in a cell already exist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2019.03.012DOI Listing

Impacts of rare earth elements on animal health and production: Highlights of cerium and lanthanum.

Sci Total Environ 2019 Mar 13;672:1021-1032. Epub 2019 Mar 13.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Because the use of antibiotics as growth promoters was banned due to global health concerns, researchers are focusing on exploring alternative safe and effective feed additives. Rare earth elements (REEs) are located in group III of the periodic table, which includes cerium (Ce), lanthanum (La), and other elements. Recently, REEs have been involved in many medical, industrial, zootechnical, and agricultural applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.02.270DOI Listing

Elucidating the biodegradation mechanism of tributyl phosphate (TBP) by Sphingomonas sp. isolated from TBP-contaminated mine tailings.

Environ Pollut 2019 Apr 3;250:284-291. Epub 2019 Apr 3.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China; Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants, Beijing, 100083, China.

Tributyl phosphate (TBP) is recognised as a global environmental contaminant because of its wide use in floatation reagents, nuclear fuel reprocessing and plasticisers. This contaminant is hardly degraded by hydrolysis in the environment due to its special physicochemical properties. In this study, one TBP-degrading strain was isolated from TBP-contaminated abandoned mine tailings, and 16S rRNA identification revealed that the strain belonged to the genus Sphingomonas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.03.127DOI Listing

Characterization of a Dibenzofuran-degrading strain of Pseudomonas aeruginosa, FA-HZ1.

Environ Pollut 2019 Apr 8;250:262-273. Epub 2019 Apr 8.

State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. Electronic address:

Dibenzofuran (DBF) derivatives have caused serious environmental problems, especially those produced by paper pulp bleaching and incineration processes. Prominent for its resilient mutagenicity and toxicity, DBF poses a major challenge to human health. In the present study, a new strain of Pseudomonas aeruginosa, FA-HZ1, with high DBF-degrading activity was isolated and identified. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02697491193032
Publisher Site
http://dx.doi.org/10.1016/j.envpol.2019.04.026DOI Listing
April 2019
1 Read

The three 'B' of fish mercury in China: Bioaccumulation, biodynamics and biotransformation.

Environ Pollut 2019 Apr 10;250:216-232. Epub 2019 Apr 10.

Department of Ocean Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, HKUST Shenzhen Research Institute, Shenzhen, 518057, China. Electronic address:

Mercury (Hg) is a global toxic pollutant and has raised the world's attention for decades. In this study, we reviewed the fish mercury levels in China (both marine and freshwater, as well as wild and farmed) documented over the past decade and their controlling environmental and biological factors. China is the largest contributor of global Hg cycling and the largest nation for the consumption and export of fish and fish product, thus Hg level in fish becomes a critical issue for food safety and public health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.04.034DOI Listing
April 2019
1 Read

Exploring the potency of integrating semi-batch operation into lipid yield performance of Chlamydomonas sp. Tai-03.

Bioresour Technol 2019 Apr 11;285:121331. Epub 2019 Apr 11.

Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan; Research Center for Circular Economy, National Cheng Kung University, Tainan 701, Taiwan; Research Center for Energy Technology and Strategy, National Cheng Kung University, Tainan 701, Taiwan; College of Engineering, Tunghai University, Taichung 407, Taiwan.

Third generation biofuels, also known as microalgal biofuels, are promising alternatives to fossil fuels. One attractive option is microalgal biodiesel as a replacement for diesel fuel. Chlamydomonas sp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biortech.2019.121331DOI Listing

Elevated atmospheric CO might increase the health risk of long-term ingestion of leafy vegetables cultivated in residual DDT polluted soil.

Chemosphere 2019 Apr 6;227:289-298. Epub 2019 Apr 6.

Institute of Environmental Microbiology, College of Resources and Environment, Fujian Agriculture & Forestry University, Fuzhou, 350002, China. Electronic address:

Residual dichlorodiphenyltrichloroethane (DDT) in the environment and a continuously increasing atmospheric carbon dioxide (CO) concentration are two issues that have received a lot of attention. This study was conducted using a pot experiment to investigate the interactive effects of elevated CO and DDT on the uptake of DDT, the physiological responses and the resulting health risks in three vegetables. These vegetables included Brassica juncea var. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.04.024DOI Listing

Peptide/receptor-like kinase-mediated signaling involved in male-female interactions.

Curr Opin Plant Biol 2019 Apr 15;51:7-14. Epub 2019 Apr 15.

State Key Laboratory for Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences at College of Life Sciences, Peking University, Beijing 100871, People's Republic of China; The National Plant Gene Research Center (Beijing), Beijing 100101, People's Republic of China. Electronic address:

In flowering plants, extensive male-female interactions during pollen germination on the stigma, pollen tube growth and guidance in the transmitting tract, and pollen tube reception by the female gametophyte are required for successful double fertilization in which various signaling cascades are involved. Peptide/receptor-like kinase-mediated signaling has been found playing important roles in these male-female interactions. Here, we mainly summarized the progress made on the regulatory roles of peptide/receptor-like kinase-mediated signaling pathways in four critical stages during reproduction in higher plants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbi.2019.03.004DOI Listing

Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer.

Biomaterials 2019 Apr 8;208:83-97. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, USA. Electronic address:

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.04.005DOI Listing

Cochliobolus sp. acts as a biochemical modulator to alleviate salinity stress in okra plants.

Plant Physiol Biochem 2019 Apr 14;139:459-469. Epub 2019 Apr 14.

Department of Botany, Garden Campus, Abdul Wali Khan University, Mardan, Pakistan.

Salinity stress can severely affect the growth and production of the crop plants. Cheap and reliable actions are needed to enable the crop plants to grow normal under saline conditions. Modification at the molecular level to produce resistant cultivars is one of the promising, yet highly expensive techniques, whereas application of endophytes on the other hand are very cheap. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plaphy.2019.04.019DOI Listing

Managing small, highly prolific invasive aquatic species: Exploring an ecosystem approach for the eastern mosquitofish (Gambusia holbrooki).

Sci Total Environ 2019 Apr 6;673:594-604. Epub 2019 Apr 6.

Department of Evolutionary Biology, Ecology and Environmental Sciences, Institute of Research in Biodiversity (IRBio-UB), Universitat de Barcelona, Spain; Department of Integrative Ecology, Estación Biológica de Doñana (EBD-CSIC), Sevilla, Spain.

Invasive exotic species threaten native biodiversity worldwide and their management is on the agenda of an increasing number of countries. We explored the potential of an ecosystem approach for the natural control of Gambusia holbrooki, which is among the most pernicious and widely distributed fish invaders. Individual-based linear mixed models were used to identify the ecosystem factors (conspecific density, environment and piscivorous birds) that most influenced life-history variation in male and female G. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.02.460DOI Listing

Overexpression of S-nitrosoglutathione reductase alleviated iron-deficiency stress by regulating iron distribution and redox homeostasis.

J Plant Physiol 2019 Apr 1;237:1-11. Epub 2019 Apr 1.

State Key Laboratory of Crop Biology, Ministry of Agriculture Key Laboratory of Horticultural Crop Biology and Germplasm Creation in Huang-Huai Region, College of Horticulture Science and Engineering, Shandong Agricultural University, Taian 271018, PR China. Electronic address:

Iron (Fe) is an essential micronutrient element for plant growth. The S-nitrosoglutathione reductase (GSNOR) gene's functions under Fe-deficiency conditions are not well understood. Here, GSNOR expression was induced by Fe deficiency in tomato (Solanum lycopersicum L. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01761617183032
Publisher Site
http://dx.doi.org/10.1016/j.jplph.2019.03.007DOI Listing
April 2019
1 Read

Preloss Psychosocial Resources Predict Depressive-Symptom Trajectories among Terminally Ill Cancer Patients' Caregivers in their First Two Years of Bereavement.

J Pain Symptom Manage 2019 Apr 15. Epub 2019 Apr 15.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Tao-Yuan, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung; School of Nursing, Chang Gung University, Tao-Yuan, Taiwan. Electronic address:

Context: Postloss depressive-symptom trajectories are heterogeneous and predicted by preloss psychosocial resources, but this evidence was from one old study on terminal cancer patients' caregivers for whom these issues are highly relevant.

Objectives: To identify depressive-symptom trajectories among cancer patients' bereaved caregivers and examine if they are predicted by preloss psychosocial resources while considering caregiving burden.

Methods: Preloss psychosocial resources (sense of coherence [SOC] and social support) were measured among 282 caregivers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpainsymman.2019.04.003DOI Listing

Developing biocompatible silver nanoparticles using epigallocatechin gallate for dental use.

Arch Oral Biol 2019 Mar 28;102:106-112. Epub 2019 Mar 28.

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. Electronic address:

Objective: To develop silver nanoparticles (AgNPs) using epigallocatechin gallate (EGCG) and evaluate its biocompatibility and inhibition effect on Streptococcus mutans biofilm growth.

Design: AgNPs were synthesized using EGCG as a reducing agent. Cytotoxicity was assessed using half-maximal inhibitory concentration (IC) against human gingival fibroblast (HGF-1) and stem cells from human exfoliated deciduous teeth (SHED). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archoralbio.2019.03.022DOI Listing

Gold nanoparticles loaded with Cullin-5 DNA increase sensitivity to 17-AAG in Cullin-5 Deficient Breast Cancer Cells.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Department of Biological Sciences, Towson University, Towson, MD, United States. Electronic address:

HSP90 inhibitors have the potential to treat many types of cancer due to the dependence of tumor cells on HSP90 for cell growth and proliferation. The Cullin-5 (Cul5) E3 ubiquitin ligase is required for HSP90 inhibitors to induce client protein degradation and subsequent cell death. Cul5 is expressed at low levels in breast cancer cells compared to patient matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.04.022DOI Listing

Haematological and intestinal health parameters of rainbow trout are influenced by dietary live yeast and increased water temperature.

Fish Shellfish Immunol 2019 Apr 15;89:525-536. Epub 2019 Apr 15.

Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Box 7024, 750 07 Uppsala, Sweden. Electronic address:

Live yeast may be a sustainable protein source in salmonid diets while exhibiting a probiotic effect to counteract environmental stressors, such as increased water temperature that is being exacerbated by climate change. The objective of this study was to evaluate the effects of feeding a high dietary inclusion of live yeast and increased water temperature on growth, haematological and intestinal physiology of rainbow trout. For six weeks, 129 g fish in 16 tanks (n = 4) were fed either a diet based on fishmeal or based on live yeast (214 g kg of diet or 7. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
Publisher Site
http://dx.doi.org/10.1016/j.fsi.2019.04.047DOI Listing
April 2019
1 Read

Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Cerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood-brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atrophy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2019.04.018DOI Listing

Genome-wide identification, phylogeny and function analysis of GRAS gene family in Dendrobium catenatum (Orchidaceae).

Gene 2019 Apr 15. Epub 2019 Apr 15.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address:

Background: In recent years, the molecular mechanism of plant growth and development has been reported in detail. GRAS genes, a plant-specific family of transcription factor, play critical roles in the process. GRAS transcription factors are associated with axillary shoot meristem formation, radial root patterning, phytohormones (gibberellins) signal transduction, light signaling, and abiotic or biotic stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.04.038DOI Listing

Four limonoids from Bacillus subtilis-fermented neem seeds and their cytotoxic activity.

Fitoterapia 2019 Apr 15. Epub 2019 Apr 15.

College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address:

Four new limonoids, 7,12-dihydroxyvilasinone (1), vilasindione (2), 4-dehydroxynimbandiol (3) and azadiramide B (4), were isolated from extracts of Bacillus subtilis-fermented neem seeds. Their planar structures and relative configurations were elucidated by spectroscopic methods including UV, IR, MS and NMR, and the absolute stereochemistry was determined by comparing their experimental and calculated CD spectra. 4 is a rare salannin-class limonoid alkaloid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fitote.2019.04.004DOI Listing

Canine distemper virus increased the differentiation of CD4CD8 T cells and mRNA expression of inflammatory cytokines in peripheral blood lymphocyte from canine.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, No. 5333 Xi'an Road, Changchun, Jilin 130062, China. Electronic address:

Background: Canine distemper virus (CDV) can cause a highly contagious disease to canid. However, how CDV affects peripheral blood lymphocyte (PBL) remains unclear.

Methods: In this study, CDV infected PBL was cultured to investigate the effect of CDV on the differentiation of lymphocytes and the mRNA expression of inflammatory cytokines in PBL. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08824010193009
Publisher Site
http://dx.doi.org/10.1016/j.micpath.2019.04.025DOI Listing
April 2019
1 Read

Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects.

J Ethnopharmacol 2019 Apr 15:111890. Epub 2019 Apr 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: Capparis erythrocarpos is a medicinal plant used widely in many parts of Africa for the management of pain and inflammatory conditions such as rheumatoid arthritis. Its wide range of use, popularity and high value, make C. erythrocarpos containing products a target for economically driven adulteration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111890DOI Listing

Comparative transcriptome analysis of human conjunctiva between normal and conjunctivochalasis persons by RNA sequencing.

Exp Eye Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.

Conjunctivochalasis (CCH) is a common ocular disease, especially in aged people. However, the molecular mechanism of CCH on transcriptional level has been unclear. In this study, we characterized the transcriptional landscape of human conjunctiva and compared the transcriptome between normal persons (n = 10) and CCH patients (n = 11). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2019.04.005DOI Listing

Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E.

Biochimie 2019 Apr 15. Epub 2019 Apr 15.

The Second Department of Orthopedics, The Fifth Hospital of Harbin, Harbin, 150040, Heilongjiang Province, PR China. Electronic address:

Osteosarcoma is an aggressive bone tumor characterized by a high level of genetic instability and recurring DNA deletions and amplifications. This study aims to investigate how microRNA-496 (miR-496) affects proliferation, invasion, and migration of human osteosarcoma (OS) cells and in vivo tumorigenicity by targeting eukaryotic translation initiation factor 4E (eIF4E). Microarray-based gene expression profiling involving OS was used in order to identify differentially expressed genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biochi.2019.04.017DOI Listing

The formation of the Thickveins (Tkv) gradient in Drosophila wing discs: A theoretical study.

Authors:
Zhan Chen

J Theor Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Mathematical Sciences, Georgia Southern University, Statesboro, GA, United States.

The development of wing imaginal disc (wing disc) is commonly adopted for the studies of patterning and growth which are two fundamental problems in developmental biology. Decapentaplegic (Dpp) signaling regulates several aspects of wing development, such as the anterior (A)-posterior (P) patterning, cellular growth rate, and cell adhesion. The distribution and activity of Dpp signaling are controlled in part by the expression level of its major type I receptor, Thickveins (Tkv). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtbi.2019.04.015DOI Listing

Automated in vivo screen in zebrafish identifies clotrimazole as targeting a metabolic vulnerability in a melanoma model.

Dev Biol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Cancer Biology, CIBIO Department, University of Trento, Via Sommarive 9, 38123 Povo TN, Italy. Electronic address:

Therapeutic approaches for cutaneous melanoma are flourishing, but despite promising results, there is an increasing number of reported primary or secondary resistance to the growing sets of drugs approved for therapy in the clinics. Combinatorial approaches may overcome resistance, as they may tackle specific weaknesses of melanoma cells, not sufficient on their own, but effective in combination with other therapies. The transgenic zebrafish line kita:ras develops melanoma with high frequency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ydbio.2019.04.005DOI Listing

Exosomes on the border of species and kingdom intercommunication.

Transl Res 2019 Mar 29. Epub 2019 Mar 29.

Consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile; Cells for Cells, Santiago, Chile; Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. Electronic address:

Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that exosomes are key players in cellular communication, carrying source-specific molecules such as proteins, growth factors, miRNA/mRNA, among others. The discovery that exosomes are not bound to intraspecies interactions, but are also capable of interkingdom communication, has once again revolutionized the field of exosomes research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2019.03.008DOI Listing

Do consumers who identify as Muslim experience culturally safe care (CSC) in the Emergency Department (ED)? A scoping review.

Australas Emerg Care 2018 Aug 1;21(3):93-98. Epub 2018 Sep 1.

School of Nursing, Midwifery and Paramedicine, Faculty of Health, University of Sunshine Coast, Maroochydore DC 4558, Queensland, Australia.

Lack of awareness about cultural and religious values and beliefs of patients presenting to Emergency Departments (ED) can compromise patient care and safety. Muslim Australians represent the fastest growing religious demographic group, with over a 77% growth in the last decade. The changing face of the Australian population requires that Australian health care carefully consider the dominant Western cultural paradigm currently influencing health care delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.auec.2018.08.001DOI Listing

The impact of unintentional alcohol-related falls on emergency departments.

Australas Emerg Care 2019 Mar 24;22(1):22-27. Epub 2018 Nov 24.

School of Health, University of New England, Armidale, NSW 2351, Australia.

Background: Alcohol is the cause of many injury presentations to the emergency department. There has been little research on alcohol-related falls in the broader adult population, which represent a substantial proportion of the total alcohol-related injury presentations to emergency departments.

Methods: A population-based retrospective analysis of public hospital emergency department presentations for Victoria for 2003-2015 was undertaken. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.auec.2018.11.001DOI Listing

Controlling nucleation in quasi-two-dimensional Langmuir poly(L-lactide) films through variation of the rate of compression.

Langmuir 2019 Apr 18. Epub 2019 Apr 18.

We studied morphological changes in a quasi-two-dimensional Langmuir film of low molar mass poly(L-lactide) upon increasing the surface density, starting from randomly distributed molecules to a homogeneous monolayer of closely packed molecules, followed by nucleation and growth of mesoscopic, three-dimensional clusters from an over-compressed monolayer. The corresponding nucleation density of mesoscopic clusters within the monolayer can be tailored through variation of the rate of compression. For a given surface density and temperature, the nucleation probability was found to increase linearly with the rate of compression, allowing to adjust the density of mesoscopic clusters over nearly two orders of magnitude. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.9b00619DOI Listing

Differential expression of androgen receptor variants in hormone-sensitive prostate cancer xenografts, castration-resistant sublines, and patient specimens according to the treatment sequence.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Androgen receptor variants (AR-vs), especially AR-v7 and AR-v 5, 6, and 7 exon-skipped (AR-v567es), are reportedly key players in the development of castration-resistant prostate cancer (CRPC). We previously established a mouse xenograft model (JDCaP) from a metastatic skin lesion from a Japanese patient with CRPC and that was revealed to exhibit androgen sensitivity. In the present study, we established multiple castration-resistant xenograft models from JDCaP mice to investigate the biological features of CRPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.23816DOI Listing

Factors associated with recovery from stunting among under-five children in two Nairobi informal settlements.

PLoS One 2019 18;14(4):e0215488. Epub 2019 Apr 18.

University of the Witwatersrand, School of Public Health, Parktown, Johannesburg, South Africa.

Childhood stunting is a public health concern in many low-and-middle income countries, as it is associated with both short-term and long-term negative effects on child cognitive development, physical health, and schooling outcomes. There is paucity of studies on recovery from stunting among under five children in these countries. Most studies focused on the recovery much later in adolescence. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215488PLOS

Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis.

PLoS Pathog 2019 Apr 18;15(4):e1007734. Epub 2019 Apr 18.

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.

The corn smut fungus Ustilago maydis requires the unfolded protein response (UPR) to maintain homeostasis of the endoplasmic reticulum (ER) during the biotrophic interaction with its host plant Zea mays (maize). Crosstalk between the UPR and pathways controlling pathogenic development is mediated by protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. Cib1/Clp1 complex formation results in mutual modification of the connected regulatory networks thereby aligning fungal proliferation in planta, efficient effector secretion with increased ER stress tolerance and long-term UPR activation in planta. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007734DOI Listing

A structural analog of ralfuranones and flavipesins promotes biofilm formation by Vibrio cholerae.

PLoS One 2019 18;14(4):e0215273. Epub 2019 Apr 18.

Department of Chemical Engineering, Howard University, Washington, District of Columbia, United States of America.

Phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) is a highly conserved, multistep chemical process which uses phosphate transfer to regulate the intake and use of sugars and other carbohydrates by bacteria. In addition to controlling sugar uptake, the PTS regulates several bacterial cellular functions such as chemotaxis, glycogen metabolism, catabolite repression and biofilm formation. Previous studies have shown that the phosphoenolpyruvate (PEP) to pyruvate ratio is a critical determinant of PTS functions. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215273PLOS
April 2019
1 Read

Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals.

PLoS One 2019 18;14(4):e0215298. Epub 2019 Apr 18.

Department of Marine Molecular Bioscience, Gangneung-Wonju National University, Gangneung-si, Ganwon-do, Korea.

Myostatin (MSTN) negatively regulates skeletal muscle growth, and its activity is inhibited by the binding of MSTN propeptide (MSTNpro), the N-terminal domain of proMSTN that is proteolytically cleaved from the proMSTN. Partial sequences from the N-terminal side of MSTNpro have shown to be sufficient to inhibit MSTN activity. In this study, to determine the minimum size of flatfish MSTNpro for MSTN inhibition, various truncated forms of flatfish MSTNpro with N-terminal maltose binding protein (MBP) fusion were expressed in E. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215298PLOS

Two components of the rhpPC operon coordinately regulate the type III secretion system and bacterial fitness in Pseudomonas savastanoi pv. phaseolicola.

PLoS Pathog 2019 Apr 18;15(4):e1007673. Epub 2019 Apr 18.

Guangdong Key Lab of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China.

Many plant bacterial pathogens including Pseudomonas species, utilize the type III secretion system (T3SS) to deliver effector proteins into plant cells. Genes encoding the T3SS and its effectors are repressed in nutrient-rich media but are rapidly induced after the bacteria enter a plant or are transferred into nutrient-deficient media. To understand how the T3SS genes are regulated, we screened for P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007673DOI Listing

Characterization of novel hydrocarbon-degrading Gordonia paraffinivorans and Gordonia sihwensis strains isolated from composting.

PLoS One 2019 18;14(4):e0215396. Epub 2019 Apr 18.

Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Hydrocarbons are important environmental pollutants, and the isolation and characterization of new microorganisms with the ability to degrade these compounds are important for effective biodegradation. In this work we isolated and characterized several bacterial isolates from compost, a substrate rich in microbial diversity. The isolates were obtained from selective culture medium containing n-hexadecane, aiming to recover alkane-degraders. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215396PLOS
April 2019
1 Read

Effects of row direction and row spacing on maize leaf senescence.

PLoS One 2019 18;14(4):e0215330. Epub 2019 Apr 18.

Northeast Institute of Geography and Agroecology, CAS, Changchun, China.

To analyze three row orientations (south-north, east-west, southwestern 20°) and two row spacings ('65 + 65', '160 + 40'), we investigated the effect of row orientation and planting pattern on photosynthetic performance, physiological and biochemical indicators related to the aging of leaves. Results revealed that during maturity stage, in north-south and east-west, the initial fluorescence (Fo) at '65 + 65' were higher than those under'160 + 40'; the maximum quantum yield of PS2 photochemistry(ΦP0), basal quantum yield of non-photochemical processes in PS2(ΦN0)of the lower leaves and photosynthetic rate of the upper and ear leaves under'160 + 40'were higher than those under'65 + 65'. The polyphenoloxidase (POD) activities of leaves at different positions under '160 + 40' were higher than that under'65 + 65', while the malondialdehyde (MDA) content was lower. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215330PLOS
April 2019
1 Read

Azospirillum brasilense promotes increases in growth and nitrogen use efficiency of maize genotypes.

PLoS One 2019 18;14(4):e0215332. Epub 2019 Apr 18.

Department of Agronomy, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

The development of cultivars with an improved nitrogen use efficiency (NUE) together with the application of plant growth-promoting bacteria is considered one of the main strategies for reduction of fertilizers use. In this sense, this study: i) evaluated the effect of Azospirillum brasilense on the initial development of maize genotypes; ii) investigated the influence of A. brasilense inoculation on NUE under nitrogen deficit; and iii) sought for more NUE genotypes with higher responsiveness to A. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215332PLOS

Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction.

PLoS One 2019 18;14(4):e0214121. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, William Beaumont Health, Royal Oak, MI, United States of America.

Objective: To interrogate the pathogenesis of intrauterine growth restriction (IUGR) and apply Artificial Intelligence (AI) techniques to multi-platform i.e. nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) based metabolomic analysis for the prediction of IUGR. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214121PLOS

"The influence of four different treatment protocols on maxillofacial growth in patients with unilateral complete cleft lip, palate, and alveolus".

Plast Reconstr Surg 2019 Apr 11. Epub 2019 Apr 11.

Background: To evaluate the effect of four different treatment protocols on maxillofacial growth in patients aged 7-8 years with UCCLPA.

Methods: 61 patients with non-syndromic unilateral complete cleft lip, palate and alveolus were selected into this study. Patients with UCCLPA who had a repaired lip and unrepaired palate were placed in group 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005711DOI Listing

Effect of Optisol Supplementation With 0.255 μg/mL Amphotericin B on Elimination of Yeast at 5°C.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA.

Purpose: Fungal infections in lamellar keratoplasty are a growing concern. Optisol-GS does not contain an antifungal agent and supplementation with 0.255 μg/mL Amphotericin B (AmpB) has been considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001969DOI Listing
April 2019
3 Reads

Obtaining and Modeling Variability in Travel Times From Off-Site Satellite Clinics to Hospitals and Surgery Centers for Surgeons and Proceduralists Seeing Office Patients in the Morning and Performing a To-Follow List of Cases in the Afternoon.

Anesth Analg 2019 Apr 15. Epub 2019 Apr 15.

From the Department of Anesthesiology, Pain Management and Perioperative Medicine, University of Miami, Miami, Florida.

Background: Hospitals achieve growth in surgical caseload primarily from the additive contribution of many surgeons with low caseloads. Such surgeons often see clinic patients in the morning then travel to a facility to do 1 or 2 scheduled afternoon cases. Uncertainty in travel time is a factor that might need to be considered when scheduling the cases of to-follow surgeons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000004148DOI Listing
  • Page 1 of 46174