2,266,803 results match your criteria Growth factors Chur Switzerland[Journal]


Phenolic Profiles, Antioxidant and Antimicrobial Activities of Pawpaw Pulp (Asimina triloba [L.] Dunal) at Different Ripening Stages.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

Dept. of Microbiology and Molecular Biology, Chungnam Natl. Univ., 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.

In this study, the phenolic components, as well as the antioxidant and antimicrobial activities, of the ripe and unripe fruit of pawpaw (Asimina triloba [L.] Dunal) extracted using five different solvents (distilled water, 95% methanol, 80% methanol, 95% ethanol, and 80% ethanol) were analyzed. The total phenolic content and total flavonoid content were the highest in the 95% ethanol (149. Read More

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http://dx.doi.org/10.1111/1750-3841.14414DOI Listing
December 2018

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

J Innate Immun 2018 Dec 17:1-13. Epub 2018 Dec 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Platelet-dense (δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products, including adenosine diphosphate (ADP), can influence inflammatory responses. We therefore aimed to study the role of platelet δ granules in the host response during sepsis. Read More

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http://dx.doi.org/10.1159/000494147DOI Listing
December 2018

Apatinib inhibits tumor growth and angiogenesis in PNET models.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

Z Wang, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Angiogenesis has a pivotal role in the growth and metastasis of pancreatic neuroendocrine tumors (PNETs). Apatinib inhibits angiogenesis as a highly selective VEGFR2 inhibitor and has been used to treat advanced gastric cancer and malignancies in clinical settings. However, the efficacy of apatinib in PNETs remains unclear. Read More

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http://dx.doi.org/10.1530/EC-18-0397DOI Listing
December 2018

Non-canonical AR activity facilitates endocrine resistance in breast cancer.

Endocr Relat Cancer 2019 Feb;26(2):251-264

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/2/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0333DOI Listing
February 2019
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O pollution in a future climate increases the competition between summer rape and wild mustard.

Plant Physiol Biochem 2018 Dec 11;135:194-205. Epub 2018 Dec 11.

Vytautas Magnus University, Department of Environmental Sciences, Vileikos St. 8-223, LT-44404, Kaunas, Lithuania.

The initial aim of this study was to evaluate an effect of elevated CO concentration and air temperature (future climate) and O pollution on mono- and mixed-culture grown summer rape (Brassica napus L.) and wild mustard (Sinapis arvensis L.). Read More

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http://dx.doi.org/10.1016/j.plaphy.2018.11.031DOI Listing
December 2018

MiR-542-3p, a microRNA targeting CDK14, suppresses cell proliferation, invasiveness, and tumorigenesis of epithelial ovarian cancer.

Biomed Pharmacother 2018 Dec 14;110:850-856. Epub 2018 Dec 14.

Department of Gynaecology and Obstetrics, Jinshan Hospital affiliated to Fudan University, Shanghai 201508, China. Electronic address:

MicroRNA-542-3p (miR-542-3p) has been implicated in several cancers; however, its precise role in ovarian cancer is unclear. In this study, we found that miR-542-3p was significantly downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. Functional assays showed that overexpression of miR-542-3p suppressed tumor cell proliferation, migration, and invasion in vitro, whereas miR-542-3p knockdown dramatically promoted tumor cell proliferation and invasion. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.104DOI Listing
December 2018

Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides.

Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:

Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.12.004DOI Listing
December 2018

Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.

Environ Int 2018 Dec 14;123:318-324. Epub 2018 Dec 14.

Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Background: Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited.

Objective: To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Read More

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http://dx.doi.org/10.1016/j.envint.2018.11.047DOI Listing
December 2018

The facile synthesis of copper oxide quantum dots on chitosan with assistance of phyto-angelica for enhancing the human osteoblast activity to the application of osteoporosis.

J Photochem Photobiol B 2018 Nov 14;191:6-12. Epub 2018 Nov 14.

Department of Orthopedics, Xiaoshan Traditional Chinese Medical Hospital, 156 Yucai Road, Hangzhou, Zhejiang 311201, PR China.

Osteoblasts are an important key factor for the pathogenesis of several bone-related diseases, notably in osteoporosis. Osteoporosis is a disorder categorized based on the bone mineral density (BMD) and an alteration in the bone micro-architecture had been considered as the major determinant for increasing the fracture risk. The available medicine for curing the osteoporosis shows a minimal or no activity against the genesis or function of osteoblasts. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.11.009DOI Listing
November 2018

Antibacterial and photocatalytic activity of hydrothermally synthesized SnO doped GO and CNT under visible light irradiation.

J Photochem Photobiol B 2018 Dec 12;191:18-25. Epub 2018 Dec 12.

Department of Civil Engineering, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address:

Bacterial and dye pollution are major problems with wastewater treatment. An increasing number of photocatalysts are being used in industry to kill bacterial and reduce pollution. In the present study, highly stable SnO-doped nanocomposites have been prepared successively by a hydrothermal method. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.12.007DOI Listing
December 2018

Predicting cadmium toxicity with the kinetics of phytochelatin induction in a marine diatom.

Aquat Toxicol 2018 Dec 11;207:101-109. Epub 2018 Dec 11.

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. Electronic address:

Phytochelatin (PC) synthesis is thought to be a rapid and specific response to metal exposure in marine phytoplankton, but its potential as a predictor of metal toxicity is far from conclusive. Thus this research examines the bioaccumulation, PC induction, and toxicity of Cadmium (Cd) in Thalassiosira weissflogii, a coastal diatom under varying nutrient conditions. Nitrogen limitation strongly inhibited Cd uptake and PC induction at the same [Cd] level, and increased metal sensitivity. Read More

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http://dx.doi.org/10.1016/j.aquatox.2018.12.008DOI Listing
December 2018

Maternal urinary benzophenones and infant birth size: Identifying critical windows of exposure.

Chemosphere 2018 Nov 28;219:655-661. Epub 2018 Nov 28.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Benzophenones (BPs) are widely used as ultraviolet absorbers and fragrance retention agents. Evidences from animal studies have suggested that exposure to BPs may affect fetal growth, but human data is limited and no study is concerning critical windows of BPs exposure throughout pregnancy in relation to fetal growth. We aimed to investigate the associations of prenatal exposure to BPs with birth size and examine the critical exposure windows of fetus development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535183229
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http://dx.doi.org/10.1016/j.chemosphere.2018.11.190DOI Listing
November 2018
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Identifying sublethal endpoints for evaluating neurotoxic compounds utilizing the fish embryo toxicity test.

Ecotoxicol Environ Saf 2018 Dec 14;170:521-529. Epub 2018 Dec 14.

Department of Biology, Texas Christian University, Fort Worth, TX, USA. Electronic address:

Fish embryos are increasingly being utilized in aquatic toxicity testing, as evidenced by the Organisation for Economic Co-operation and Development's approval of the fish embryo acute toxicity (FET) test. However, the FET test only allows for the estimation of acute toxicity, whereas other test methods such as the larval growth and survival (LGS) test allow for the estimation of both acute and chronic toxicity. Additionally, it has been demonstrated that the FET test is less sensitive than other test methods for some neurotoxic compounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513183126
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http://dx.doi.org/10.1016/j.ecoenv.2018.11.118DOI Listing
December 2018
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The Intestinal Lymphatic System: Functions and Metabolic Implications.

Cell Mol Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Cardiovascular Research Center and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA; INSERM U970, Paris Cardiovascular Research Center, 75015 Paris, France.

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last two decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183017
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http://dx.doi.org/10.1016/j.jcmgh.2018.12.002DOI Listing
December 2018
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Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More

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http://dx.doi.org/10.1016/j.actbio.2018.12.019DOI Listing
December 2018

Effects of ALAD genotype on the relationship between lead exposure and anthropometry in a Cohort of Mexican children.

Environ Res 2018 Dec 5;170:65-72. Epub 2018 Dec 5.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:

Objectives: Lead exposure is associated with children's growth, but this relationship may depend on the presence of susceptibility factors, including genetic variation. Blood lead levels (BLL) differ by ALAD (aminolevulinic acid dehydratase) genotype. We investigated the association between BLL and growth in Mexican first-graders with different ALAD genotypes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.003DOI Listing
December 2018

Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India. Electronic address:

Microneedle-devices provide a promising alternative to syringe-injection-based administration of chemotherapeutics. Dissolvable polymeric microneedles provide possibility of carrying greater payload and dual drugs. Here, we report development of polyvinyl pyrrolidone and polyvinyl alcohol composite dissolvable polymeric microneedle system for co-delivery of doxorubicin HCl and docetaxel. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.022DOI Listing
December 2018
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Methotrexate-loaded biodegradable polymeric micelles for lymphoma therapy.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Hematology and Research Laboratory of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center, Chengdu, 610041, PR China. Electronic address:

Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive subtypes of lymphoma, such as Burkitt's lymphoma, in order to overcome drug resistance. But poor solubility of the free drug and severe side effects of HD MTX limit its clinical application. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.025DOI Listing
December 2018

RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability.

Int J Pharm 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China.

Nanocrystals has been constructed for insoluble drugs as a novel type of nanoscale drug delivery systems with high drug loading. How to prepare nanocrystals with good stability and tumor targeting capability is still challenging. This study was to modify paclitaxel nanocrystals with polyethylene glycol (PEG) for stabilization and RGD peptide for tumor targeting. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.023DOI Listing
December 2018

Mechanistic modelling of Radium-223 treatment of bone metastases.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.

Introduction: Despite the effectiveness of RaCl for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions. In silico tumour models bring a new perspective to this as they can quantitatively simulate the interaction of α-particles with the target(s). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.015DOI Listing
December 2018
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Effects of chitosan nanoparticles on seed germination and seedling growth of wheat (Triticum aestivum L.).

Int J Biol Macromol 2018 Dec 14. Epub 2018 Dec 14.

Liaoning Provincial Key Laboratory of Carbohydrates, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

To investigate the effect and mechanism of chitosan nanoparticles (CSNPs) on the germination and seedling growth of wheat (Triticum aestivum L.), we conducted systematic research on the impact of different concentrations (1-100 μg/mL) of CSNPs and chitosan (CS). The result of energy-dispersive spectroscopy (EDS) and confocal laser scanning microscopy (CLSM) showed that adsorption of CSNPs on the surface of wheat seeds was higher than that of CS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183485
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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.118DOI Listing
December 2018
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The Slt2-MAPK pathway is involved in the mechanism by which target of rapamycin regulates cell wall components in Ganoderma lucidum.

Fungal Genet Biol 2018 Dec 14. Epub 2018 Dec 14.

Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, P.R. China. Electronic address:

The fungal cell wall is very important for cell growth and survival during stress, and the target of rapamycin (TOR) pathway plays a major role in regulating cell growth in response to environmental cues. Ganoderma lucidum is an important edible and medicinal fungus, and the function of TOR in this organism remains unclear. As shown in the present study, the TOR pathway regulates cell wall integrity (CWI) in G. Read More

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http://dx.doi.org/10.1016/j.fgb.2018.12.005DOI Listing
December 2018

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin.

Free Radic Biol Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China. Electronic address:

Dihydroartemisinin (DHA) has been shown to be capable of inhibiting cancer growth, whereas it remains largely elusive that the underlying molecular mechanism of DHA induced acute myeloid leukemia (AML) cell death. In the present study, we examined the effects of DHA on the proliferation and ferroptosis of AML cells as well as to elucidate the underlying molecular mechanisms. We found that DHA strongly inhibited the viability of AML cell lines and arrest cell cycle at G0/G1 phase. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.011DOI Listing
December 2018

TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells.

Cell Signal 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Genes Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:

High level expression of lipocalin 2 (LCN2) usually indicates poor prognosis in esophageal squamous cell carcinoma (ESCC) and many other cancers. Our previous study showed LCN2 promotes migration and invasion of ESCC cells through a novel positive feedback loop. However, the key transcription activation protein (KTAP) in the loop had not yet been identified. Read More

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http://dx.doi.org/10.1016/j.cellsig.2018.12.007DOI Listing
December 2018

Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease.

Neurochem Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA. Electronic address:

Manganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopaminergic cells. Read More

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http://dx.doi.org/10.1016/j.neuint.2018.12.003DOI Listing
December 2018

High fidelity recovery of airborne microbial genetic materials by direct condensation capture into genomic preservatives.

J Microbiol Methods 2018 Dec 14. Epub 2018 Dec 14.

University of Colorado, Environmental Engineering Program, Boulder, CO, USA. Electronic address:

A condensation growth tube was adapted to capture bacterial bioaerosols directly into genomic preservatives. As judged by quantitative PCR and direct microscopy, bioaerosol condensation capture conserves airborne microbes' genomes as they exist in the atmospheric environment. This method circumvents the collection stresses bioaerosols experience on air filters, impactors and impingers. Read More

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http://dx.doi.org/10.1016/j.mimet.2018.12.010DOI Listing
December 2018

Naturally-occurring right terminal hairpin mutations in three genotypes of canine parvovirus (CPV-2a, CPV-2b and CPV-2c) have no effect on their growth characteristics.

Virus Res 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China. Electronic address:

We have isolated 4 naturally-occurring strains of CPV in mainland China and have identified them as CPV-2, 2a, 2b and 2c genotypes according to their VP2 sequences which also revealed substitutions within their right terminal regions. To determine if these substitutions affected the growth characteristics of the 4 strains, we constructed plasmids based on their genomic sequences minus their right terminal sequences, with the latter replaced by a single right terminal region. Analysis of rescued recombinants showed that the substitutions within their natural right termini had no significant effect on their growth characteristics. Read More

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http://dx.doi.org/10.1016/j.virusres.2018.12.007DOI Listing
December 2018

Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Lung cancer remains the leading cause of cancer-related deaths despite recent breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has also been applied for lung cancer, postulating that an often small proportion of tumor cells with stem cell properties are responsible for tumor growth, therapeutic resistance and metastasis. The identification of these CSCs and underlying molecular maintenance mechanisms is considered to be absolutely necessary for developing therapies for their riddance, hence achieving remission. Read More

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http://dx.doi.org/10.1016/j.bcp.2018.12.010DOI Listing
December 2018

Fluvastatin-mediated down-regulation of SATB1 affects aggressive phenotypes of human non-small-cell lung cancer cell line H292.

Life Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Aims: Fluvastatin reduces tumor proliferation and increased apoptotic activity in various cancers. Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that reprogrammes the gene transcription profiles of tumors to promote growth and metastasis. The antitumor effect and molecular mechanisms of fluvastatin on lung cancer is poorly understood. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.022DOI Listing
December 2018

Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Justus-Leibig-University, Internal Medicine, Giessen, Germany ;

Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Fucoidan, polysacharidic ligand of an adhesion molecule P-selectin exhibits anti-proliferative properties. The effects of Fucoidan/P-selectin axis on vascular remodeling and pulmonary hypertension (PH) following hypoxia remain unexplored. Read More

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http://dx.doi.org/10.1164/rccm.201806-1170OCDOI Listing
December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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http://doi.wiley.com/10.1002/14651858.CD008901.pub4
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http://dx.doi.org/10.1002/14651858.CD008901.pub4DOI Listing
December 2018
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The ecological roles of tryptanthrin, indirubin and N-formylanthranilic acid in Isatis indigotica: phytoalexins or phytoanticipins?

Chem Biodivers 2018 Dec 17. Epub 2018 Dec 17.

Univesity of Saskatchewan, Dept. of Chemistry, 110 Science Place, S7N 5C9, Saskatoon, CANADA.

Leaves of the plant species Isatis indigotica Fort. (Chinese woad) produce the metabolites tryptanthrin, indirubin and N-formylanthranilic acid upon spraying with an aq. solution of copper chloride but not after spraying with water. Read More

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http://dx.doi.org/10.1002/cbdv.201800579DOI Listing
December 2018

EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma.

PLoS Pathog 2018 Dec 17;14(12):e1007484. Epub 2018 Dec 17.

Shenzhen Key Laboratory of Viral Oncology, the Clinical Innovation & Research Center (CIRC), Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007484
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http://dx.doi.org/10.1371/journal.ppat.1007484DOI Listing
December 2018
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Early-life environmental exposures and childhood growth: A comparison of statistical methods.

PLoS One 2018 17;13(12):e0209321. Epub 2018 Dec 17.

Department of Mathematics and Statistics, Williams College, Williamstown, MA, United States of America.

There is a growing literature that suggests environmental exposure during key developmental periods could have harmful impacts on growth and development of humans. Understanding and estimating the relationship between early-life exposure and human growth is vital to studying the adverse health impacts of environmental exposure. We compare two statistical tools, mixed-effects models with interaction terms and growth mixture models, used to measure the association between exposure and change over time within the context of non-linear growth and non-monotonic relationships between exposure and growth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209321PLOS
December 2018

Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.

PLoS One 2018 17;13(12):e0209250. Epub 2018 Dec 17.

Department of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.

Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment of Alzheimer's disease (AD). To elucidate whether Riv causes neuronal differentiation, we examined its effect on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. At concentrations of 0-100 μM, Riv was non-toxic in PC12 cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209250PLOS
December 2018

Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.

PLoS One 2018 17;13(12):e0208846. Epub 2018 Dec 17.

Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America.

There is evidence from longitudinal studies that being light at birth and weaning is associated with subsequent rapid weight gain in infants. This is referred to as "centile crossing", which can lead to increased risk of lifetime obesity, glucose dysregulation and type 2 diabetes. Here, pregnant CD-1 mice were hemi-ovariectomized so that the entire litter was contained in one uterine horn to increase variability in fetal growth rate. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208846PLOS
December 2018

miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2.

PLoS Genet 2018 Dec 17;14(12):e1007790. Epub 2018 Dec 17.

Department of Radiation Oncology, North China University of Science and Technology Affiliated People's Hospital, Tangshan, China.

Accumulating evidence indicates that miRNAs can be promising diagnostic and/or prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607-3p, and its targets in non-small cell lung cancer (NSCLC). The expression of miR-3607-3p was measured and its correlation with patient prognosis was determined. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007790DOI Listing
December 2018

Diel versus time-integrated (daily) photosynthesis and irradiance relationships of coral reef organisms and communities.

PLoS One 2018 17;13(12):e0208607. Epub 2018 Dec 17.

Coral Reef Ecology and Optics Laboratory (CREOL), Bermuda Institute of Ocean Sciences (BIOS), St. George's, Bermuda.

The most important source of energy to tropical shallow water coral reefs is light, the transformation of which ultimately limits reef biomass and growth. Therefore, measurements of productivity (primary production, P) for benthic reef organisms and communities are critical to understand reef functioning. Short-term (minutes to hours) P measurements of reef photosynthesizers virtually always produce the classic hyperbolic tangent (or similar) P-E (irradiance) relationship, with P rapidly rising to a saturation point as E increases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208607PLOS
December 2018
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Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137.

PLoS One 2018 17;13(12):e0208732. Epub 2018 Dec 17.

Department of Chemistry, University of Iowa, Iowa City, Iowa, United States of America.

Hydrogen sulfide (H2S) is a key gasotransmitter in agriculture and has been reported to increase the growth of plants in the first two weeks and to mitigate the effects of environmental stressors. GYY-4137 is widely used in these studies because it slowly releases H2S, but there is disagreement as to whether it requires enzymes to release H2S. In this article we describe the release of H2S in water without enzymes and that it releases H2S faster in organic solvents than in water or when mixed in topsoil. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208732PLOS
December 2018
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Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

PLoS One 2018 17;13(12):e0209296. Epub 2018 Dec 17.

Department of Tumor Biology, Institute of Biomedical Sciences, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate, Japan.

Cultured cells easily develop resistance to kinesin-5 inhibitors (K5Is) often by overexpressing a related motor protein, kinesin-12/KIF15, or by acquiring mutations in the N-terminal motor domain of kinesin-5/KIF11 itself. We aimed to identify novel mechanisms responsible for resistance to S-trityl L-cysteine (STLC), one of the K5Is, using human osteosarcoma cell lines. Among six lines examined, U-2OS and HOS survived chronic STLC treatment and gave rise to resistant cells with IC50s at least 10-fold higher than those of the respective parental lines. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209296PLOS
December 2018

Morpho-physiological responses of tall wheatgrass populations to different levels of water stress.

PLoS One 2018 17;13(12):e0209281. Epub 2018 Dec 17.

Department of Plant Biology and Soil Science, Faculty of Biology, University of Vigo, Vigo, Pontevedra, Spain.

Tall wheatgrass [Elymus elongatus subsp. ponticus (Podp.) Melderis] is a perennial forage grass cultivated in dry, saline or alkaline environments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209281PLOS
December 2018

β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.

PLoS Genet 2018 Dec 17;14(12):e1007846. Epub 2018 Dec 17.

Science Division, Biology Program, New York University Abu Dhabi (NYUAD), Abu Dhabi, United Arab Emirates.

During neuronal development, β-actin serves an important role in growth cone mediated axon guidance. Consistent with this notion, in vivo ablation of the β-actin gene leads to abnormalities in the nervous system. However, whether β-actin is involved in the regulation of neuronal gene programs is not known. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007846DOI Listing
December 2018

Expression and Activity of Matrix Metalloproteinases in Leukemia.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Matrix metalloproteinases (MMPs) are responsible for the degradation of extracellular matrix components and hence play a crucial role in physiological and pathologic processes. The imbalance between the expression of MMPs and their inhibitors can be effective in leukemic cell processes such as migration, angiogenesis, survival, and apoptosis, playing a key role in the progression and prognosis of leukemia. In this review, we discuss the potential involvement of MMPs and their inhibitors in the pathogenesis and progression of leukemia by examining their role in the prognosis of leukemia. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001386DOI Listing
December 2018
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What's wrong with neutrophils in lupus?

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Polymorphonuclear neutrophils (PMNs) act by promoting phagocytosis, and are regarded as the first line of defense against pathogen invasion. However, recent investigations have revealed that they have many previously unknown functions. These functions include mitogen-induced cell-mediated cytotoxicity, production of cytokines/chemokines/growth factors, and release of neutrophil extracellular traps (NETs) and ectosomes/exosomes. Read More

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November 2018

Implant planning in a case with Sotos Syndrome.

J Oral Implantol 2018 Dec 17. Epub 2018 Dec 17.

1 Universidade de Santiago de Compostela Prosthodontics Universidade de Santiago de Compostela.

Sotos syndrome it is usually transmitted by autosomal dominant inheritance. It is characterized by overgrowth with advanced bone age, macrocephaly, characteristic facial appearance, and learning difficulties. Mandibular prognathism, agenesis, and high-arched palate are the most common oral findings. Read More

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http://www.joionline.org/doi/10.1563/aaid-joi-D-18-00181
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http://dx.doi.org/10.1563/aaid-joi-D-18-00181DOI Listing
December 2018
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Investigation of galectin-3 levels in diabetic foot ulcers.

J Wound Care 2018 Dec;27(12):843-848

Professor, Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Objective:: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Read More

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http://www.magonlinelibrary.com/doi/10.12968/jowc.2018.27.12
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http://dx.doi.org/10.12968/jowc.2018.27.12.843DOI Listing
December 2018
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Sustainable location and route planning with GIS for waste sorting centers, case study: Kerman, Iran.

Waste Manag Res 2018 Dec 17:734242X18815950. Epub 2018 Dec 17.

2 Department of Industrial Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran.

One of the important issues in the world is the significant growth of waste production, including waste that is not biodegradable in nature. According to the Kerman Municipality, 440 tonnes of municipal waste is collected daily in Kerman consisting of five major parts of paper, plastic, metal, glass, and wet waste. The major problems of municipal solid waste disposal are soil erosion, air pollution, and greenhouse gas emissions. Read More

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http://dx.doi.org/10.1177/0734242X18815950DOI Listing
December 2018

Impedance-Based Detection of Bacteria.

Chem Rev 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry , University of California , Berkeley , California 94720-1460 , United States.

Pathogenic bacteria have always posed one of the most serious threats to public health, and continue to be especially dangerous with the rise in antibiotic resistance. The prevalence of these infectious agents necessitates rapid, point-of-care sensors for their detection, identification, and monitoring. Electrochemical sensors are promising for the low-cost monitoring of bacterial growth and the detection of specific microbial species due to the consistency and ease-of-use of impedance measurements. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00381DOI Listing
December 2018

Tooth development and replacement in the Atlantic Cutlassfish, Trichiurus lepturus, with comparisons to other Scombroidei.

J Morphol 2019 Jan;280(1):78-94

Department of Ecology and Evolutionary Biology and Cornell University Museum of Vertebrates, Cornell University, Ithaca, New York.

Atlantic Cutlassfish, Trichiurus lepturus, have large, barbed, premaxillary and dentary fangs, and sharp dagger-shaped teeth in their oral jaws. Functional teeth firmly ankylose to the dentigerous bones. We used dry skeletons, histology, SEM, and micro-CT scanning to study 92 specimens of T. Read More

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http://dx.doi.org/10.1002/jmor.20919DOI Listing
January 2019

Antimicrobial effects of the ginsenoside Rh2 on monospecies and multispecies cariogenic biofilms.

J Appl Microbiol 2018 Dec 17. Epub 2018 Dec 17.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-Most) & Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, China.

Aims: To investigate the effects of the ginsenoside Rh2 on monospecies and multispecies cariogenic biofilms and explore the mechanism of the antibiofilm effect of Rh2 in vitro.

Methods And Results: Streptococcus mutans, Streptococcus sobrinus, and Streptococcus sanguinis were chosen to form the monospecies or multispecies biofilms. Crystal violet staining and laser scanning confocal microscopy were used to observe the effect of Rh2 on biofilms in vitro. Read More

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http://doi.wiley.com/10.1111/jam.14178
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http://dx.doi.org/10.1111/jam.14178DOI Listing
December 2018
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