2,262,395 results match your criteria Growth Hormone Replacement in Older Men


Identifying Potentially Modifiable Factors Associated with Treatment Non-Adherence in Paediatric Growth Hormone Deficiency: A Systematic Review.

Horm Res Paediatr 2018 Dec 6;90(4):1-7. Epub 2018 Dec 6.

Background: Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence.

Methods: A search of 11 electronic databases was undertaken to identify relevant articles, published in English, between 1985 and 2018. Read More

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December 2018
2 Reads

Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway.

Cell Physiol Biochem 2018 6;51(5):2136-2147. Epub 2018 Dec 6.

Background/aims: Long non-coding RNAs (lncRNAs) play vital roles in carcinogenesis as oncogenes or tumor suppressor genes. This study explored the biological function of lncRNA gastric adenocarcinoma predictive long intergenic non-coding RNA (GAPLINC) in human non-small cell lung cancer (NSCLC).

Methods: GAPLINC expression in NSCLC specimens and cell lines was detected by qRT-PCR and Western blot. Read More

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December 2018
2 Reads

Sestrin 2 Attenuates Rat Hepatic Stellate Cell (HSC) Activation and Liver Fibrosis via an mTOR/AMPK-Dependent Mechanism.

Cell Physiol Biochem 2018 6;51(5):2111-2122. Epub 2018 Dec 6.

Department of Infectious Diseases, The Third Affiliated Hospital of Wenzhou Medical University, Rui'an,

Background/aims: Sestrin 2 is associated with the pathophysiology of several diseases. The aim of this study was to investigate the effects and potential mechanisms of Sestrin 2 in rat hepatic stellate cells (HSCs) during liver fibrogenesis.

Methods: In this study, Sestrin 2 protein expression was detected in rat HSC-T6 cells challenged with transforming growth factor-β (TGF-β) and in mice treated with carbon tetrachloride (CCl4), a well-known model of hepatic fibrosis. Read More

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December 2018
2 Reads

Intraventricular blood flow with a fully dynamic mitral valve model.

Comput Biol Med 2018 Nov 29;104:197-204. Epub 2018 Nov 29.

Department of Chemical Engineering, Faculty of Applied Science, Delft University of Technology, the Netherlands.

Mitral valve (MV) leaflets affect the formation, growth, and decay of vortices in the left ventricle (LV) during diastolic filling. The shape and motion of MV leaflets are simplified in most studies due to computational restrictions. In this study, we present a newly developed mathematical method to model the dynamic movement of valve leaflets and annulus, which is based on in vivo data obtained with magnetic resonance imaging (MRI). Read More

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November 2018
3 Reads

Discovery and development of small molecule modulators targeting glutamine metabolism.

Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More

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November 2018
5 Reads
3.447 Impact Factor

Viability-based quantification of antibiotic resistance genes and human fecal markers in wastewater effluent and receiving waters.

Sci Total Environ 2018 Nov 22;656:495-502. Epub 2018 Nov 22.

Department of Civil and Environmental Engineering, Rutgers, The State University of New Jersey, 500 Bartholomew Dr, Piscataway, NJ 08854, United States. Electronic address:

Antibiotic resistance is a public health issue with links to environmental sources of antibiotic resistance genes (ARGs). ARGs from nonviable sources may pose a hazard given the potential for transformation whereas ARGs in viable sources may proliferate during host growth or conjugation. In this study, ARGs in the effluent from three municipal wastewater treatment plants (WWTPs) and the receiving surface waters were investigated using a viability-based qPCR technique (vPCR) with propidium monoazide (PMA). Read More

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November 2018
2 Reads

Temporal fluctuations in young-of-the-year yellow perch mercury bioaccumulation in lakes of northeastern Minnesota.

Sci Total Environ 2018 Nov 22;656:475-481. Epub 2018 Nov 22.

USDA Forest Service, Superior National Forest, 8901 Grand Ave Place, Duluth, MN 55808, USA. Electronic address:

Identifying what determines fish mercury (Hg) bioaccumulation remains a key scientific challenge. While there has been substantial research on spatial variation in fish Hg bioaccumulation, the factors that influence temporal fluctuations in fish Hg have received less attention to date. In this study, we built upon a growing body of research investigating young-of-the-year (YOY) yellow perch Hg bioaccumulation and investigated annual fluctuations in YOY yellow perch Hg in six lakes in northeastern Minnesota over eight years. Read More

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November 2018
2 Reads

Food up-take and reproduction performance of Daphnia magna under the exposure of Bisphenols.

Ecotoxicol Environ Saf 2018 Dec 3;170:47-54. Epub 2018 Dec 3.

Key laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) & School of Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Because the application of Bisphenol A (BPA) was restricted, many substitutes, such as Bisphenol F (BPF) and Bisphenol S (BPS), were developed as BPA substitutes. Therefore, environmental impacts of BPA and its substitutes on aquatic organisms should be concerned, especially their combined toxicity. In this study, the impacts of BPA, BPF, BPS and their mixture on the feeding behavior, reproduction and physiological function of daphnids were synthetically evaluated, involving the duration and mode of exposure. Read More

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December 2018
4 Reads

Physiological and biochemical effect of silver on the aquatic plant Lemna gibba L.: Evaluation of commercially available product containing colloidal silver.

Aquat Toxicol 2018 Nov 27;207:52-62. Epub 2018 Nov 27.

Josip Juraj Strossmayer University of Osijek, Department of Biology, Ulica cara Hadrijana 8/A, HR-31000, Osijek, Croatia. Electronic address:

This paper aims to evaluate the effects of a product containing colloidal silver in the aquatic environment, using duckweed Lemna gibba as a model plant. Therefore, growth parameters, photosynthetic pigments content and protein content as physiological indices were evaluated. Changes in the content of non-enzymatic antioxidants and activity of several antioxidant enzymes, alongside with the accumulation of hydrogen peroxide and lipid peroxidation end-products were assessed to explore the potential of colloidal silver to induce oxidative stress. Read More

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November 2018
1 Read

Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae.

J Proteomics 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Drug resistance in bacteria is becoming a significant threat to global public health, and the development of novel and efficient antibacterial compounds is urgently needed. Recently, rhodium complexes have attracted attention as antimicrobial agents, yet their antibacterial mechanism remains unknown. In this study, we observed that the dirhodium (II) complex RhAc inhibited Streptococcus. Read More

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December 2018
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The unique spatial-temporal treatment failure patterns of adjuvant gefitinib therapy: A post-hoc analysis of the ADJUVANT trial (CTONG 1104).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Introduction: Adjuvant gefitinib therapy prolonged disease-free survival (DFS) in patients with resected early-stage epidermal growth factor receptor (EGFR)-mutation positive non-small cell lung cancer (NSCLC) in the ADJUVANT study (CTONG 1104). However, treatment failure patterns after gefitinib therapy are less well characterized.

Methods: Overall, 222 stage N1-N2, EGFR-mutant NSCLC patients received gefitinib or vinorelbine plus cisplatin (VP) treatment. Read More

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December 2018
4 Reads

Enrichment of common carp (Cyprinus carpio) fingerlings diet with Psidium guajava: The effects on cutaneous mucosal and serum immune parameters and immune related genes expression.

Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

The present study aimed at evaluation of possible effects of Psidium guajava as immunostimulant on mucosal and serum immunity, as well as related genes expression in common carp (Cyprinus carpio) fingerlings. In an eight weeks feeding trial, fish were fed with experimental diets containing guava leaf powder [GLP] (0, 0.25, 0. Read More

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December 2018
5 Reads

TroCCL4, a CC chemokine of Trachinotus ovatus, is involved in the antimicrobial immune response.

Fish Shellfish Immunol 2018 Dec 3;86:525-535. Epub 2018 Dec 3.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China.

CC chemokines are a large subfamily of chemokines that play an important role in the innate immune system. To date, several CC chemokines have been identified in fish species; however, the activities and functions of these putative chemokines remain ambiguous in teleosts, especially in the golden pompano, Trachinotus ovatus. Here, we characterized CC chemokine ligand 4 from T. Read More

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December 2018
2 Reads

Beneficial effect of Curcumin Nanoparticles-Hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies.

Ann Anat 2018 Dec 3;222:94-102. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.

Management of diabetic wounds remains a major challenge in the medical field, mostly due to incompetent outcomes of treatments. Curcumin has been documented as anti-inflammatory, antioxidant, antimicrobial and antineoplastic agent in addition to wound healing activities. However, its poor aqueous solubility and impaired skin permeation handicap its topical pharmaceutical usage. Read More

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December 2018
7 Reads

Mulberry leaf polysaccharides suppress renal fibrosis.

Authors:
Shengjun Wu

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Huaihai Institute of Technology, 59 Cangwu Road, Haizhou 222005, China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, 59 Cangwu Road, Haizhou 222005, China; Jiangsu Key Laboratory of Marine Biotechnology, 59 Cangwu Road, Haizhou 222005, China. Electronic address:

A mulberry leaf polysaccharide (MLP-1) was prepared and partially characterised, and its anti-renal-fibrosis effects were investigated in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats. MLP-1, with a molecular weight of 2,792,624 Da, consisted of arabinose, glucose, xylose, rhamnose, and mannose in a molar ratio of 1:1.13:2. Read More

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December 2018
1 Read

Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression.

Int J Biol Macromol 2018 Dec 4. Epub 2018 Dec 4.

Department of Biochemistry and Molecular Biology, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address:

A lectin with a molecular mass of 12 ± 1 kDa was isolated for the first time from Geodorum densiflorum (Lam.) rhizome (GDL). The lectin exhibited hemagglutination activity both in mice and human erythrocytes which was inhibited by 4-nitrophenyl-β-D-glucopyranoside among the tested 26 sugars. Read More

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December 2018
2 Reads
2.858 Impact Factor

In vitro fermentation of O‑acetyl‑arabinoxylan from bamboo shavings by human colonic microbiota.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, PR China.

BSH-1 is an O‑acetyl-arabinoxylan obtained from bamboo shavings. This study investigated its fermentation behavior by human colonic bacteria in vitro. Results showed that BSH-1 remarkably modulated the composition of colonic microbiota, mainly by increasing the growth of potential beneficial genera (i. Read More

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December 2018
3 Reads

Pilot-scale isolation and characterization of extracellular polymeric substances (EPS) from cell-free medium of Spirulina sp. LEB-18 cultures under outdoor conditions.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Federal University of Bahia, Salvador, Brazil.

This objective of this work was to monitor the EPS production during the growth of Spirulina sp. LEB-18, evaluate the productivity and to characterize the exopolymers obtained on pilot-scale under outdoor conditions. The production of crude EPS occurred in all phases of biomass growth and was approximately ten folds higher than that biomass concentration of Spirulina sp. Read More

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December 2018

Physicochemical responses and microbiological changes of bream (Megalobrama ambycephala) to pectin based coatings enriched with clove essential oil during refrigeration.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, PR China. Electronic address:

The effectiveness of pectin coatings enriched with clove essential oil (CEO), as new edible coatings were investigated to preserve bream (Megalobrama ambycephala) fillets during refrigeration over a period of 15 days. All samples were analyzed for physicochemical (pH, PV, TBA and TVB-N), microbiological (Total viable count, Psychrophilic bacteria, Lactic acid bacteria, Enterobacteriaceae, Pseudomonas spp., HS producing bacteria) and organoleptic attributes. Read More

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December 2018
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Radiation-mediated molecular weight reduction and structural modification in carrageenan potentiates improved photosynthesis and secondary metabolism in peppermint (Mentha piperita L.).

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Botany, Aligarh Muslim University, Aligarh 202002, India.

In an attempt to gain insights into the possible relationship between the irradiation-mediated molecular weight reduction and structural modification and the growth-promotion activity, characterization of the polysaccharide before and after irradiation was carried out through Fourier Transform Infrared (FT-IR), Ultraviolet-visible (UV-vis) and Nuclear Magnetic Resonance (NMR) spectroscopic studies. Moreover, graded concentrations of irradiated carrageenan (IC) were applied through foliage to assess the performance of peppermint (Mentha piperita L.). Read More

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December 2018
2 Reads

Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death.

Int J Biol Macromol 2018 Dec 3;124:1060-1068. Epub 2018 Dec 3.

Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea. Electronic address:

Colorectal cancer is the third most diagnosed cancer and a leading cause of cancer death. Dissatisfaction with currently available anti-colorectal cancer drugs caused by unwanted side effects and low efficacy necessitates new therapeutic agents. In the present study, a sulfated glucuronorhamnoxylan polysaccharide (named SPS-CF) purified from a green alga Capsosiphon fulvescens was evaluated for its anti-cancer activity in vitro and in vivo against colorectal cancer. Read More

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December 2018
1 Read

Identification and molecular analysis of a lncRNA-HOTAIR transcript from secondary hair follicle of cashmere goat reveal integrated regulatory network with the expression regulated potentially by its promoter methylation.

Gene 2018 Dec 3. Epub 2018 Dec 3.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, PR China. Electronic address:

The HOTAIR transcript is transcribed from the antisense strand within the HOXC gene cluster, and it is thought to play a role in regulating the inductive capacity of dermal papilla cells during the reconstruction of hair-follicle. In the current investigation, we firstly isolated and characterized a lncRNA-HOTAIR transcript from the secondary hair follicle of cashmere goat. Also, we analyzed its transcriptional pattern and methylation level of HOTAIR gene promoter in secondary hair follicle of cashmere goat during anagen and telogen stages. Read More

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December 2018
1 Read

HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Department of Traumatic Orthopedics, The Second Hospital Affiliated to Lanzhou University, Lanzhou City, Gansu Province 730000, China.

Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not fully understood. Read More

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December 2018
1 Read

Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;; Department of Veterans Affairs, Nashville, TN, USA. Electronic address:

Cytochrome CYP450 epoxygenases catalyze the epoxidation of polyunsaturated fatty acids including arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. The arachidonic acid-derived products are potent pro-angiogenic lipids and promote tumor development and growth. On the other hand, eicosapentaenoic acid- and docosahexaenoic acid-derived products inhibit angiogenesis and play a protective role in certain pathological conditions including cancer. Read More

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December 2018
2 Reads

NEW INSIGHTS ON THE REGULATION OF CANCER CACHEXIA BY N-3 POLYUNSATURATED FATTY ACIDS.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, Brazil,; Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;. Electronic address:

Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Read More

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December 2018
2 Reads

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 4;124:139-150. Epub 2018 Dec 4.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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December 2018

Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma.

Biochim Biophys Acta Mol Cell Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment and SUSTech-HKU Joint Laboratories for Matrix Biology and Diseases, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Hepatocellular carcinoma (HCC) is a long-term consequence of chronic inflammatory liver injury. Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products including lipopolysaccharide (LPS), which promotes hepatocarcinogenesis. Despite its clinical significance, the molecular mediator linking chronic inflammation with HCC development remains to be clarified. Read More

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December 2018
2 Reads

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2.

Osteoarthritis Cartilage 2018 Dec 3. Epub 2018 Dec 3.

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei province, China. Electronic address:

Objective: This study aimed to explore potential microRNAs (miRNAs), which participate in the pathological process of condylar hyperplasia (CH) through targeting specific proliferation- and apoptosis-related genes of chondrocytes.

Methods: Insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R) and B-cell CLL/lymphoma 2 (BCL2) in CH cartilage were detected by real-time PCR, Western blot, immunohistochemistry and immunofluorescence. MiRanda and TargetScanS algorithms were used to predict certain miRNAs in CH chondrocytes concurrently modulating the above three genes. Read More

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December 2018
1 Read

Virulence properties of Vibrio vulnificus isolated from diseased zoea of freshness shrimp Macrobrachium rosenbergii.

Microb Pathog 2018 Dec 4;127:166-171. Epub 2018 Dec 4.

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. Electronic address:

Macrobrachium rosenbergii is one of the most economically important freshwater shimp, with fast growth and high nutrient content in the agricultural development of China. However, it had been suffering diseases infection, causing mass death and great economic losses. In the present study, a bacteria strain was isolated from the diseased zoea of M. Read More

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December 2018

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2018 Dec 4;127:31-43. Epub 2018 Dec 4.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More

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December 2018
2 Reads

Hydrogels with prolonged release of therapeutic antibody: Block junction chemistry modification of 'ABA' copolymers provides superior anticancer efficacy.

J Control Release 2018 Dec 4;293:193-200. Epub 2018 Dec 4.

31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

In this study, we report a new series of vitamin E-functionalized 'ABA' triblock copolymers with carbamate block junction, which can form hydrogen-bonds. These polymers were synthesized via solvent- and catalyst-free nucleophilic addition between PEG-diamine and vitamin E-functionalized cyclic carbonate. The catalyst-free synthesis enabled an easy purification step and recycling of excess monomers. Read More

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December 2018
2 Reads

Enzymes of glycerol-3-phosphate pathway in triacylglycerol synthesis in plants: Function, biotechnological application and evolution.

Prog Lipid Res 2018 Dec 3. Epub 2018 Dec 3.

Programa de Pós-Graduação em Genética e Biologia Molecular, Departmento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.. Electronic address:

Triacylglycerols (TAG) are the major form of energy storage in plants. TAG are primarily stored in seeds and fruits, but vegetative tissues also possess a high capacity for their synthesis and storage. These storage lipids are essential to plant development, being used in seedling growth during germination, pollen development, and sexual reproduction, for example. Read More

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December 2018
2 Reads

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption.

Gastroenterology 2018 Dec 3. Epub 2018 Dec 3.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801. Electronic address:

Background & Aims: The nuclear receptor subfamily 0 group B member 2 (NR0B2, also called SHP) is expressed at high levels in liver and intestine. Postprandial fibroblast growth factor 19 (human FGF19, mouse FGF15) signaling increases the transcriptional activity of SHP. We studied the functions of SHP and FGF19 in intestines of mice, including their regulation of expression of the cholesterol transporter NPC1-like intracellular cholesterol transporter 1 (NPC1L1) and cholesterol absorption. Read More

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December 2018
1 Read

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.

Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:

Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More

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December 2018
6 Reads

CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

Exp Neurol 2018 Dec 3. Epub 2018 Dec 3.

Cellular Neurobiology Laboratories, The Salk Institute, La Jolla, CA, USA.

Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent with the potential to positively impact a large population of brain ischemia patients and revolutionize the process used for the development of new drugs to treat complex brain disorders. Read More

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December 2018
2 Reads

Preterm newborn's postnatal growth patterns: how to evaluate them.

J Pediatr (Rio J) 2018 Dec 3. Epub 2018 Dec 3.

Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Pediatria, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Serviço de Neonatologia, Porto Alegre, RS, Brazil.

Objectives: There are several factors that influence the postnatal growth of preterm infants. It is crucial to define how to evaluate the growth rate of each preterm child and its individual trajectory, the type of growth curve, either with parameters of prescriptive curves for healthy preterm infants with no morbidities or, in the case of preterm infants and their "bundle of vulnerabilities", growth curves that may represent how they are actually growing, with the aim of directing appropriate nutritional care to each gestational age range.

Data Sources: The main studies with growth curves for growth monitoring and the appropriate nutritional adjustments that prioritized the individual trajectory of postnatal growth rate were reviewed. Read More

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December 2018

Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury.

Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.

The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Critical Care Medicine, Guangzhou, Guangdong, China.

Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS).

Objective: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS.

Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Read More

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December 2018
2 Reads

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
6 Reads

Multi-light responsive quantum dot sensitized hybrid micromotors with dual-mode propulsion.

Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.

University of Alcalá, Analytical Chemistry and Chem. Ing., Ctra Madrid-Barcelona km 33,600, 28871, Alcalá de Henares, SPAIN.

CdS quantum dots/C60 tubular micromotors with chemical/multi-light-controlled propulsion and "on-the-fly" acceleration capabilities are described. "In-situ" growth of CdS quantum dots on the outer fullerene layer impart them with light-responsive properties in connection to inner Pt, Pd or MnO2 layers. This is the first time that visible-light is used to drive bubble propelled tubular micromotors. Read More

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December 2018

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5785-5794

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Purpose: Posterior capsule opacification (PCO) is a complication after cataract surgery, particularly in children. Epithelial-mesenchymal transition (EMT) of lens epithelial cells, mediated by transforming growth factor beta (TGFβ), contributes to PCO. However, its pathogenesis in children is poorly understood. Read More

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December 2018
3 Reads

Estimating lake ice thickness in Central Ontario.

PLoS One 2018 6;13(12):e0208519. Epub 2018 Dec 6.

Climate Research Division, Environment and Climate Change Canada, Toronto, Ontario, Canada.

Lakes are a key geographical feature in Canada and have an impact on the regional climate. In the winter, they are important for recreational activities such as snowmobiling and ice fishing and act as part of an important supply route for northern communities. The ability to accurately report lake ice characteristics such as thickness is vital, however, it is underreported in Canada and there is a lack of lake ice thickness records for temperate latitude areas such as Central Ontario. Read More

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December 2018
1 Read
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