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    13521 results match your criteria Growth Hormone Deficiency

    1 OF 271

    Endocr Pract 2018 Mar;24(3):288-293
    Objective: The total cortisol (TC) response may be measured during the glucagon stimulation test (GST) for growth hormone (GH) reserve in order to assess the integrity of the hypothalamic-pituitary-adrenal (HPA) axis. Measurements of TC are unreliable in conditions of albumin and cortisol-binding globulin (CBG) alterations (e.g. Read More

    Growth hormone - past, present and future.
    Nat Rev Endocrinol 2018 Mar 16. Epub 2018 Mar 16.
    Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
    Growth hormone (GH) research and its clinical application for the treatment of growth disorders span more than a century. During the first half of the 20th century, clinical observations and anatomical and biochemical studies formed the basis of the understanding of the structure of GH and its various metabolic effects in animals. The following period (1958-1985), during which pituitary-derived human GH was used, generated a wealth of information on the regulation and physiological role of GH - in conjunction with insulin-like growth factors (IGFs) - and its use in children with GH deficiency (GHD). Read More

    Genome-wide and comparative analysis of bHLH38, bHLH39, bHLH100 and bHLH101 genes in Arabidopsis, tomato, rice, soybean and maize: insights into iron (Fe) homeostasis.
    Biometals 2018 Mar 15. Epub 2018 Mar 15.
    Department of Crop and Animal Production, Cilimli Vocational School, Duzce University, Cilimli, Duzce, Turkey.
    Iron (Fe) is an essential element for plant life. Its deficiency impedes growth and development and excessive iron can cause the toxic effect via the Fenton reaction. Thus, plants have developed various mechanisms to acquire, distribute and utilize Fe for the maintenance of their iron homeostasis at cellular and systemic levels. Read More

    [Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State].
    Dtsch Med Wochenschr 2018 Mar 15;143(6):384-391. Epub 2018 Mar 15.
    Background:  Diabetic ketoacidosis and the hyperosmolar hyperglycemic state are the most serious diabetic emergencies. Before the discovery of insulin in 1921 by Banting and Best the diagnosis of type 1 diabetes was fatal ending in diabetic ketoacidosis equivalent to a torturous death. Today, mortality from diabetic ketoacidosis is low at approximately 2 %. Read More

    A novel variant c.97C>T of the Growth Hormone Releasing Hormone Receptor gene causes isolated growth hormone deficiency type Ib.
    J Clin Res Pediatr Endocrinol 2018 Feb 28. Epub 2018 Feb 28.
    Congenital Isolated growth hormone deficiency (IGHD) type Ib is an autosomal recessive genetic condition caused by mutations of GH1 or the GH releasing hormone receptor (GHRH-R) gene. Affected subjects present symptoms of GHD with low but detectable levels of GH, short stature and responsiveness to GH therapy. We describe a 13-month old girl with severe growth failure who showed a low hGH in response to 2 hGH provocative tests and a modest increase of IGF-I to an IGF-I generation test. Read More

    Analysis of characteristics and outcomes by growth hormone treatment duration in adult patients in the Italian cohort of the Hypopituitary Control and Complications Study (HypoCCS).
    J Endocrinol Invest 2018 Mar 13. Epub 2018 Mar 13.
    St. Andrea Hospital, Rome, Italy.
    Purpose: To examine differences in effects according to growth hormone (GH) treatment duration in adult GH-deficient patients.

    Methods: In the Italian cohort of the observational Hypopituitary Control and Complications Study, GH-treated adults with GH deficiency (GHD) were grouped by duration of treatment; ≤ 2 years (n = 451), > 2 to ≤ 6 years (n = 387) and > 6 years (n = 395). Between-group differences in demographics, medical history, physical characteristics, insulin-like growth factor-I standard deviation score (IGF-I SDS) and lipid profile at baseline, last study visit and changes from baseline to last study visit were assessed overall, for adult- and childhood-onset GHD and by gender using ANOVA for continuous variables and Chi-squared test for categorical variables. Read More

    Analysis of physiological and miRNA responses to Pi deficiency in alfalfa (Medicago sativa L.).
    Plant Mol Biol 2018 Mar 12. Epub 2018 Mar 12.
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
    Key Message: The induction of miR399 and miR398 and the inhibition of miR156, miR159, miR160, miR171, miR2111, and miR2643 were observed under Pi deficiency in alfalfa. The miRNA-mediated genes involved in basic metabolic process, root and shoot development, stress response and Pi uptake. Inorganic phosphate (Pi) deficiency is known to be a limiting factor in plant development and growth. Read More

    Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency.
    Front Endocrinol (Lausanne) 2018 23;9:56. Epub 2018 Feb 23.
    Weill Cornell Medicine Qatar, Doha, Qatar.
    Objective: The aim of this study is to evaluate the effect of growth hormone therapy (rGH) on mitochondrial function on peripheral muscle and to correlate with exercise capacity in subjects with severe adult growth hormone deficiency (GHD).

    Design: Six months, double-blind, randomized, crossover, placebo-controlled trial of subcutaneous rGH in 17 patients with GHD.

    Measurements: Quadriceps muscle biopsies were obtained at baseline, 3 months, and 6 months to measure succinate dehydrogenase (SDH) to assess mitochondrial activity. Read More

    Growth hormone deficiency and pregnancy: any role for substitution?
    Minerva Endocrinol 2018 Mar 8. Epub 2018 Mar 8.
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
    Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Read More

    [Clinical characteristics of central diabetes insipidus: a retrospective analysis of 230 cases].
    Zhonghua Nei Ke Za Zhi 2018 Mar;57(3):201-205
    Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
    To evaluate the clinical characteristics and etiologies of central diabetes insipidus (CDI).The clinical data of 230 patients with CDI in the Department of Endocrinology of Chinese PLA General Hospital from 2008 June to 2014 December were collected and analyzed retrospectively.The three most common causes of CDI were idiopathic CDI, lymphocytic hypophysitis and intracranial germ cell tumors. Read More

    Chronic Hypopituitarism Associated with Increased Postconcussive Symptoms Is Prevalent after Blast-Induced Mild Traumatic Brain Injury.
    Front Neurol 2018 19;9:72. Epub 2018 Feb 19.
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.
    The most frequent injury sustained by US service members deployed to Iraq or Afghanistan is mild traumatic brain injuries (mTBI), or concussion, by far most often caused by blast waves from improvised explosive devices or other explosive ordnance. TBI from all causes gives rise to chronic neuroendocrine disorders with an estimated prevalence of 25-50%. The current study expands upon our earlier finding that chronic pituitary gland dysfunction occurs with a similarly high frequency after blast-related concussions. Read More

    Acetylcholine modulates the hormones of the Growth Hormone/Insulin-Like Growth Factor-1 axis during development in mice.
    Endocrinology 2018 Mar 2. Epub 2018 Mar 2.
    Inserm UMR1141-PROTECT, Université Paris-Diderot, Sorbonne Paris Cité, Hôpital Robert Debré, Paris, France.
    Pituitary growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and somatostatin (SRIF), and a gastrointestinal hormone, ghrelin. The neurotransmitter acetylcholine (ACh) is involved in tuning GH secretion, and its GH-stimulatory action has mainly been shown in adults but is not clearly documented during development. Read More

    Pituitary height at magnetic resonance imaging in pediatric isolated growth hormone deficiency.
    Pediatr Radiol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Radiology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathumwan, Bangkok, 10330, Thailand.
    Background: Magnetic resonance imaging (MRI) is used for neuroradiologic evaluation of patients with idiopathic growth hormone deficiency (IGHD).

    Objectives: To compare pituitary height and morphology at MRI between patients with IGHD and controls.

    Materials And Methods: This retrospective study was conducted in pediatric patients, 3 years-15 years old, who had had brain MRI with non-contrast-enhanced midsagittal T1-weighted images. Read More

    Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos.
    BMC Dev Biol 2018 Mar 5;18(1). Epub 2018 Mar 5.
    Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
    Background: Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and partially restore dysmorphogenesis in tbx5 morphants. This study aimed to further evaluate the effects of IGF-I on cell apoptosis and dysmorphogenesis in zebrafish embryos deficient for tbx5. Read More

    Vitamin D: part I; from plankton and calcified skeletons (500 million years ago) to rickets.
    Int Orthop 2018 Mar 5. Epub 2018 Mar 5.
    Hôpital Henri Mondor, 94010, Creteil, France.
    The vitamin D history started early in the evolution of life (billion years ago) as a photochemical reaction producing an inert molecule. During the early evolution of vertebrates, this molecule became essential for calcium and bone homeostasis of terrestrial animals and arrived to the status of hormone. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. Read More

    Safety and Convenience of Once-Weekly Somapacitan in Adult GH Deficiency: A 26-Week Randomized, Controlled Trial.
    Eur J Endocrinol 2018 Mar 2. Epub 2018 Mar 2.
    M Rasmussen, Global Development, Novo Nordisk, Søborg, Denmark
    Objective: Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily NorditropinLocal tolerability and treatment satisfaction were also assessed.

    Design: 26-week randomized, controlled phase 3 safety and tolerability trial in six countries (NCT02382939). Read More

    Eur J Endocrinol 2018 Mar 2. Epub 2018 Mar 2.
    H Storr, Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, EC1M 6BQ, United Kingdom of Great Britain and Northern Ireland
    Background: Patients with homozygous intronic pseudoexon GH receptor(GHR) mutations(6Ψ) have growth hormone Insensitivity(GHI) (growth failure, IGF1 deficiency and normal/elevated serum GH). We report 9 patients in addition to previously described 11 GHR 6Ψ patients and their responses to rhIGF1 therapy.

    Methods: 20 patients (12 males, 11 families, mean age 4. Read More

    Hormonal, metabolic and skeletal phenotype of Schaaf-Yang syndrome: a comparison to Prader-Willi syndrome.
    J Med Genet 2018 Mar 1. Epub 2018 Mar 1.
    Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.
    Background: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed genelocated in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature. Scoliosis and growth hormone insufficiency are also prevalent in PWS. Read More

    The Role of Insulin Resistance/Hyperinsulinism on the Rising Trend of Thyroid and Adrenal Nodular Disease in the Current Environment.
    J Clin Med 2018 Feb 26;7(3). Epub 2018 Feb 26.
    Department of Endocrinology, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
    Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules, under the influence of growth stimulatory factors. Among the main stimulatory factors are the pituitary tropic hormones, thyroid-stimulating hormone (TSH) or thyrotropin and adrenocorticotropic hormone (ACTH), which regulate the growth and function of their respective target cells, and the insulin/insulin-like growth factor system, that, through its mitogenic effects, can stimulate the proliferation of these cells. Read More

    Preliminary findings on the association between attachment patterns and levels of growth hormone in a sample of children with non-organic failure to thrive
    Riv Psichiatr 2018 Jan-Feb;53(1):49-52
    Department of Experimental Medicine, Section of Medical Pathophysiology and Endocrinology, Sapienza University of Rome, Italy.
    Introduction: Deficiency of growth hormone (GH) in absence of pituitary injuries is one of the causes of short stature and of the non organic failure to thrive (NOFTT) condition. Advances in developmental psychology have highlighted the role of emotions and caregiving behaviors in the organization of child’s personality and psychobiology, with the mother-son attachment bond being considered a fundamental developmental experience. The objective of the present preliminary study was to assess whether there are significant correlations between attachment patterns and GH levels in a sample of subjects with NOFTT. Read More

    Multi-centre phase IV trial to investigate the immunogenicity of a new liquid formulation of recombinant human growth hormone in adults with growth hormone deficiency.
    J Endocrinol Invest 2018 Feb 27. Epub 2018 Feb 27.
    School of Medicine, University of Western Sydney, Sydney, Australia.
    Purpose: To investigate whether a new liquid formulation of recombinant human growth hormone (r-hGH) induces the production of binding antibodies (BAbs) in adults with congenital or adult-onset growth hormone deficiency (GHD).

    Methods: Men or women aged 19-65 years with adult growth hormone deficiency who were r-hGH-naïve or had stopped treatment ≥ 1 month before screening were treated with between 0.15 and 0. Read More

    Effects of fetal hypothyroidism on uterine smooth muscle contraction and structure of offspring rats.
    Exp Physiol 2018 Feb 27. Epub 2018 Feb 27.
    Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    New Findings: What is the central question of this study? Does fetal hypothyroidism in rats alter uterine contractions and structure in the adult offspring? What is the main finding and its importance? Our study indicated that maternal hypothyroidism during pregnancy increased gestational length and decreased litter size as well as delayed puberty onset; in addition, maternal hypothyroidism caused irregular uterine contractions and histological changes in the uterus in the female offspring. This model may contribute to a better understanding of the cellular and molecular mechanisms involved in uterine contractions in fetal hypothyroidism, studies which are not possible in humans, and may help for establishing therapeutic methods for these disorders observed in uterine contractions.

    Abstract: Thyroid hormones play an essential role in fetal growth. Read More

    The second point mutation in PREPL: a case report and literature review.
    J Hum Genet 2018 Feb 26. Epub 2018 Feb 26.
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
    Prolyl endopeptidase-like (PREPL) deficiency (MIM# 616224) is a rare autosomal recessive inherited congenital myasthenic syndrome characterized by neonatal hypotonia, feeding problems, mild dysmorphism, and neuromuscular symptoms, followed by hyperphagia and obesity in later childhood. Some patients also exhibit growth deficits, sexual hormone deficiency, and cognitive impairments. This syndrome is caused by biallelic mutations in PREPL. Read More

    Vitamin D status in prepubertal children with isolated idiopathic growth hormone deficiency: effect of growth hormone therapy.
    J Investig Med 2018 Feb 24. Epub 2018 Feb 24.
    Department of Clinical and Chemical Pathology, National Research Center, Cairo, Egypt.
    Few studies, and with controversial results, analyzed vitamin D status in children before and after growth hormone (GH) treatment. Thus, we aimed to assess vitamin D status in prepubertal children with idiopathic growth hormone deficiency (GHD), and to evaluate the effect of GHD and GH treatment on vitamin D levels. Fifty prepubertal children with isolated GHD were compared with 50 controls. Read More

    Dental caries and vitamin D3 in children with growth hormone deficiency: A STROBE compliant study.
    Medicine (Baltimore) 2018 Feb;97(8):e9811
    Department of Paediatric Endocrinology and Diabetology with Endocrine- Metabolic Laboratory, Medical University of Lublin.
    Vitamin D may prevent dental caries. To date, no attempts have been made to examine the correlation between the incidence of caries and the concentrations of vitamin D in children with pituitary growth hormone deficiency.The study observed patients of the Department of Endocrinology and Diabetology of the University Paediatric Hospital of the Medical University of Lublin treated with human recombinant growth hormone for pituitary growth hormone deficiency (GHD). Read More

    Post-Traumatic Hypopituitarism-Who Should Be Screened, When, and How?
    Front Endocrinol (Lausanne) 2018 2;9. Epub 2018 Feb 2.
    Department of Endocrinology, Beaumont Hospital and School of Medicine, Royal College Surgeons in Ireland, Dublin, Ireland.
    Traumatic brain injury (TBI) remains a major, global public health concern. Over the last 15 years, a significant body of evidence has emerged demonstrating that post-traumatic hypopituitarism (PTHP) is a common and clinically significant consequence of TBI. Non-specific symptomology and the lack of an agreed approach to screening for PTHP has led to significant under-diagnosis of this debilitating disease. Read More

    The psychometric evaluation of the quality of life in short stature youth (QoLISSY) instrument for German children born small for gestational age.
    J Endocrinol Invest 2018 Feb 17. Epub 2018 Feb 17.
    Department of Medical Psychology, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
    Purpose: This study aimed to validate the disease-specific "quality of life in short stature youth (QoLISSY)-instrument" that assessesQuery the health-related quality of life (HrQoL) in German children and adolescents diagnosed as small for gestational age (SGA) in a patient and parent report.

    Methods: The psychometric performance of the German version of the QoLISSY questionnaire was examined in terms of reliability and validity in 65 SGA families (17 child reports/64 parent reports) and compared to the psychometric performance of the original European QoLISSY dataset of over 200 children with growth hormone deficiency and idiopathic short stature (ISS).

    Results: The analysis yielded psychometrically favorable results with excellent reliability and acceptable discriminant validity. Read More

    Somatolactogens and diabetic retinopathy.
    Growth Horm IGF Res 2018 Feb 6. Epub 2018 Feb 6.
    Department of Biochemistry and Molecular Medicine, School of Medicine, Universidad Autónoma de Nuevo León, Av. Madero Col. Mitras Centro S/N, Monterrey, NL 64460, Mexico; TecSalud del Tecnológico de Monterrey, Centro Médico Zambrano-Hellion, Batallón San Patricio 112, Real de San Agustín, 66278 San Pedro Garza García, Nuevo León, Mexico; Vitagénesis, SA de CV. Blvd, Puerta del Sol #1005, Colinas de San Jerónimo, Monterrey, NL 64630, Mexico. Electronic address:
    Importance: Diabetic retinopathy (DR) is one of the most common of all diabetic complications. The number of people with DR in the United States is expected to increase to 16 million by 2050. DR is the leading cause of blindness among working-age adults in many different countries, including the United States. Read More

    Final adult height and endocrine complications in young adults with β-thalassemia major (TM) who received oral iron chelation (OIC) in comparison with those who did not use OIC.
    Acta Biomed 2018 Feb 16;89(2-S):27-32. Epub 2018 Feb 16.
    University of Alexandria, Alexandria, Egypt.
    Background: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox.

    Aims Of The Study: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients.

    Patients And Methods: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years). Read More

    Primary growth hormone insensitivity and psychomotor delay.
    Clin Case Rep 2018 Feb 18;6(2):426-431. Epub 2018 Jan 18.
    Escuela de MedicinaTecnologico de MonterreyMonterreyMexico.
    We report a case of short stature irresponsive to growth hormone (GH) replacement therapy. Low GH response to provocative tests and undetectable IGF-1 levels had suggested GH deficiency, while response to therapy indicated GH insensitivity. Molecular evaluation of the GH/IGF-1 axis should be performed in these cases to improve diagnosis and therapy. Read More

    Argininemia as a cause of severe chronic stunting and partial growth hormone deficiency (PGHD): A case report.
    Medicine (Baltimore) 2018 Feb;97(7):e9880
    Department of Pediatrics, West China Second University Hospital.
    Rationale: Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations - including spastic diplegia, deterioration in cognitive function, and epilepsy - appear in later childhood.

    Patient Concerns: A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy. Read More

    Functions of vitamin D in bone.
    Histochem Cell Biol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Medicine, McGill University, Montreal, QC, Canada.
    Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Loss-of function mutations in the genes encoding the enzymes regulating these processes, or in the VDR, result in human diseases, which have demonstrated the paramount role of 1,25(OH)D in mineral and skeletal homeostasis. Mouse genetics has been used to create disease phenocopies which have produced considerable insight into the mechanisms of 1,25(OH)D regulation of mineral and skeletal metabolism. Read More

    Design of the Growth hormone deficiency and Efficacy of Treatment (GET) score and non-interventional proof of concept study.
    BMC Endocr Disord 2018 Feb 13;18(1):10. Epub 2018 Feb 13.
    Clinical, Medical & Regulatory Department, Novo Nordisk Pharma GmbH, 55127, Mainz, Germany.
    Background: The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a score summarising the features of GHD and evaluate its ability to measure the effect of GH substitution in AGHD.

    Methods: The Growth hormone deficiency and Efficacy of Treatment (GET) score (0-100 points) assessed (weighting): HRQoL (40%), disease-related days off work (10%), bone mineral density (20%), waist circumference (10%), low-density lipoprotein cholesterol (10%) and body fat mass (10%). Read More

    Evaluation of growth hormone response to GHRH plus arginine test in children with idiopathic short stature: role of peak time.
    J Endocrinol Invest 2018 Feb 8. Epub 2018 Feb 8.
    Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
    Purpose: To describe the course of growth hormone response to growth hormone releasing hormone (GHRH) plus arginine provocative test in children with idiopathic short stature (ISS) and to evaluate the role of peak time.

    Methods: A retrospective study was performed analyzing 344 GHRH plus arginine provocative tests performed in children and adolescents with short stature. Serum GH levels were measured at four-time points (T0', T30', T45' and T60') and GH peak was defined as the maximum value at any time point. Read More

    Treatment of adult growth hormone deficiency with human recombinant growth hormone: an update on current evidence and critical review of advantages and pitfalls.
    Endocrine 2018 Feb 7. Epub 2018 Feb 7.
    Department of Endocrinology, Hospital Universitario La Princesa, Instituto de Investigación Princesa, Universidad Autónoma, Madrid, Spain.
    Adult-onset growth-hormone (GH) deficiency (GHD) is a rare disorder, which most commonly results from pituitary or peripituitary tumors and their treatment, and is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral density, cardiovascular risk profile and quality of life, all of which may contribute to an increased morbidity and mortality. Since recombinant human GH (rhGH) became available in 1985, several studies have provided evidence of its beneficial effects, despite the potential risk of developing adverse effects, and much clinical experience has been accumulated. However, in adults, the precise therapeutic role of GH replacement therapy and the individual response to it remains highly variable and is still a matter of debate. Read More

    FSH may be a useful tool to allow early diagnosis of Turner syndrome.
    BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.
    Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.
    Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

    Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

    Influence of vitamin D receptor polymorphisms on biochemical markers of mineral bone disorders in South African patients with chronic kidney disease.
    BMC Nephrol 2018 02 7;19(1):30. Epub 2018 Feb 7.
    Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: It remains unclear whether genetic factors may explain the reported variation in the levels of biochemical markers of chronic kidney disease mineral and bone disorders (CKD- MBD) across ethnic groups. Therefore, the aim of this study was to examine the influence of vitamin D receptor (VDR) polymorphisms on secondary hyperparathyroidism and its association with vitamin D levels in black and white South African study participants.

    Methods: This was a cross sectional study involving 272 CKD stage 3- 5D patients and 90 healthy controls. Read More

    Growth hormone deficiency with advanced bone age: phenotypic interaction between GHRH receptor and CYP21A2 mutations diagnosed by sanger and whole exome sequencing.
    Arch Endocrinol Metab 2017 Dec;61(6):633-636
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP Brasil.
    Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7. Read More

    Ethylene signaling triggered by low concentrations of ascorbic acid regulates biomass accumulation in Arabidopsis thaliana.
    Free Radic Biol Med 2018 Feb 2. Epub 2018 Feb 2.
    Instituto de Fisiología Vegetal, Facultad Ciencias Agrarias y Forestales, Universidad Nacional de La Plata-CCT CONICET La Plata, cc327 (1900), La Plata, Argentina. Electronic address:
    Ascorbic acid (AA) is a major redox buffer in plant cells. The role of ethylene in the redox signaling pathways that influence photosynthesis and growth was explored in two independent AA deficient Arabidopsis thaliana mutants (vtc2-1 and vtc2-4). Both mutants, which are defective in the AA biosynthesis gene GDP-L-galactose phosphorylase, produce higher amounts of ethylene than wt plants. Read More

    Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice.
    Hepatol Commun 2017 Dec 16;1(10):1024-1042. Epub 2017 Oct 16.
    NGM Biopharmaceuticals, Inc.South San FranciscoCA.
    Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive research, the cellular mechanisms that mediate NAFLD pathogenesis and progression are poorly understood. Although obesity, diabetes, insulin resistance, and related metabolic syndrome, all consequences of a Western diet lifestyle, are well-recognized risk factors for NAFLD development, dysregulated bile acid metabolism is emerging as a novel mechanism contributing to NAFLD pathogenesis. Read More

    Low FT4 Concentrations around the Start of Recombinant Human Growth Hormone Treatment: Predictor of Congenital Structural Hypothalamic-Pituitary Abnormalities?
    Horm Res Paediatr 2018 18;89(2):98-107. Epub 2018 Jan 18.
    Department of Pediatric Endocrinology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
    Background: Growth hormone (GH) treatment may unmask central hypothyroidism (CeH). This was first observed in children with GH deficiency (GHD), later also in adults with GHD due to acquired "organic" pituitary disease. We hypothesized that newly diagnosed CeH in children after starting GH treatment for nonacquired, apparent isolated GHD points to congenital "organic" pituitary disease. Read More

    GH and GHR signaling in human disease.
    Growth Horm IGF Res 2018 02 12;38:34-38. Epub 2017 Dec 12.
    Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Ecuador.
    Along with its inherent properties in growth promotion, cell division and regeneration, growth hormone (GH) exerts a variety of miscellaneous and widespread actions on the human body after binding to its receptor (GHR). Indeed, GH influences the metabolism of carbohydrates, lipids and proteins; shapes body composition, influences cardiovascular profile, quality of life, and induces other direct and indirect physiologic effects. Besides this salutary actions, GH and its derived peptide insulin-like growth factor-I (IGF-I), main product of the GH/GHR interaction, have been implicated in the genesis of diseases such as cancer and insulin-resistant diabetes. Read More

    Interplay between cytochrome c and gibberellins during Arabidopsis vegetative development.
    Plant J 2018 Jan 31. Epub 2018 Jan 31.
    Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Cátedra de Biología Celular y Molecular, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 3000, Santa Fe, Argentina.
    We studied the effect of reducing the levels of the mitochondrial electron carrier cytochrome c (CYTc) in Arabidopsis thaliana. Plants with CYTc deficiency have delayed growth and development, and reach flowering several days later than the wild-type but with the same number of leaves. CYTc-deficient plants accumulate starch and glucose during the day, and contain lower levels of active gibberellins (GA) and higher levels of DELLA proteins, involved in GA signaling. Read More

    TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP-ATF response elements in the Fgf21 promoter.
    Biochim Biophys Acta 2018 Mar 31;1861(3):271-281. Epub 2018 Jan 31.
    Estonian Biocentre, Institute of Genomics, University of Tartu, Riia 23b, 51010 Tartu, Estonia. Electronic address:
    Mammals must be able to endure periods of limited food availability, and the liver plays a central role in the adaptation to nutritional stresses. TRIB3 (Tribbles homolog 3) is a cellular stress-inducible gene with a liver-centric expression pattern and it has been implicated in stress response regulation and metabolic control. In the current article, we study the involvement of TRIB3 in responses to nutrient deficiencies, including fasting for up to 48 h in mice. Read More

    Partial growth hormone insensitivity and dysregulatory immune disease associated with de novo germline activating STAT3 mutations.
    Mol Cell Endocrinol 2018 Feb 1. Epub 2018 Feb 1.
    Centro de Investigaciones Endocrinológicas 'Dr César Bergadá' (CEDIE), CONICET, FEI, División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. Electronic address:
    Germinal heterozygous activating STAT3 mutations represent a novel monogenic defect associated with multi-organ autoimmune disease and, in some cases, severe growth retardation. By using whole-exome sequencing, we identified two novel STAT3 mutations, p.E616del and p. Read More

    Growth Hormone, Insulin-Like Growth Factor-1, Insulin Resistance, and Leukocyte Telomere Length as Determinants of Arterial Aging in Subjects Free of Cardiovascular Diseases.
    Front Genet 2017 15;8:198. Epub 2017 Dec 15.
    National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
    Increased arterial stiffness (AS), intima-media thickness (IMT), and the presence of atherosclerotic plaques (PP) have been considered as important aspects of vascular aging. It is well documented that the cardiovascular system is an important target organ for growth hormone (GH) and insulin-like growth factor (IGF)-1 in humans, and GH /IGF-1 deficiency significantly increases the risk for cardiovascular diseases (CVD). The telomere length of peripheral blood leukocytes (LTL) is a biomarker of cellular senescence and that has been proposed as an independent predictor of (CVD). Read More

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