125,279 results match your criteria Growth Hormone & IGF Research [Journal]


Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes.

Toxicol In Vitro 2019 Apr 19. Epub 2019 Apr 19.

National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli 350, Taiwan. Electronic address:

Previous studies revealed that cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) disturbed energy metabolism in adipocytes, where glucose uptake was significantly increased. The present study aimed to determine the mechanisms underlying the increased glucose uptake. MEHP-treated 3T3-L1 adipocytes exhibited a significantly increased glucose uptake activity. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.021DOI Listing

Health-Related Quality of Life in Turner Syndrome and the Influence of Growth Hormone Therapy: a 20-Year Follow-up.

J Clin Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Department of Behavioral and Community Dentistry, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Context: The factors that affect the Health-Related Quality of Life (HRQoL) of women with Turner Syndrome (TS) are controversial.

Objective: The aim was to describe the HRQoL of women with TS with a focus on how given growth hormone (GH) treatment and comorbidity influence HRQoL in adulthood, and to compare HRQoL of women with TS with that of women in the general population.

Design: Longitudinal cohort study, up to 20 years. Read More

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http://dx.doi.org/10.1210/jc.2019-00340DOI Listing

Role of programmed cell death ligand-1 expression on prognostic and overall survival of breast cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15201

Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China.

Background: Recently, the correlation of immunological checkpoint marker programmed cell death ligand-1 (PD-L1) and the prognosis of various cancers has been a research hotspot. The aim of this study is to examine the prognostic effect of PD-L1 in breast cancer.

Methods: PubMed, EMBASE, Web of Science, the Cochrane Library database were searched for eligible studies and additional hand-searching were reviewed as an augmentation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015201DOI Listing

FGF23 Synthesis and Activity.

Curr Mol Biol Rep 2019 Mar 17;5(1):18-25. Epub 2019 Jan 17.

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

Purpose Of Review: The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH) vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases. This review will focus on recent studies examining the synthesis and actions of FGF23. Read More

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http://dx.doi.org/10.1007/s40610-019-0111-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469709PMC

Chronic Stress and Ovarian Function in Female Childhood Cancer Survivors.

Oncol Nurs Forum 2019 May;46(3):E75-E85

Marquette University.

Objectives: To explore the relationships among perceived stress, biomarkers of hypothalamic-pituitary-adrenal (HPA) activity, gonadotropin levels, and anti-Müllerian hormone (AMH) in female childhood cancer survivors (CCSs).

Sample & Setting: 24 female CCSs from the Royal Hospital for Sick Children in Edinburgh, Scotland, were included in the study.

Methods & Variables: Perceived stress was measured using the Perceived Stress Scale. Read More

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http://dx.doi.org/10.1188/19.ONF.E75-E85DOI Listing

The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps.

Am J Rhinol Allergy 2019 Apr 22:1945892419843828. Epub 2019 Apr 22.

1 Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Relaxin is a small peptide hormone that regulates extracellular matrix remodeling and reduces fibrosis in a number of organs. Little is known about its impact on chronic rhinosinusitis with nasal polyps (CRSwNP); thus, we aimed to determine the expression of human H2 relaxin (relaxin-2) and its role in tissue remodeling in CRSwNP.

Methods: Patients were enrolled and divided into the following groups: CRS with NP (CRSwNP; n = 20), CRS without NP (CRSsNP; n = 20), and controls (n = 15). Read More

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http://dx.doi.org/10.1177/1945892419843828DOI Listing

Comparison of follicular development, timing of ovulation and serum progesterone, estradiol and luteinizing hormone concentrations in dairy heifers treated with 4- or 5-day CoSynch + CIDR protocols.

Vet Med Sci 2019 Apr 22. Epub 2019 Apr 22.

Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, USA.

The use of 4-day CoSynch + Controlled internal drug release (CIDR) + timed artificial insemination (TAI) in dairy heifers has resulted in adequate pregnancy rates compared with the 5-day CoSynch + CIDR + TAI protocol. The objective of this study was to compare follicular growth, timing of ovulation and serum progesterone (P ), estradiol (E ) and luteinizing hormone (LH) concentrations in dairy heifers treated with modified 4- or 5-day CoSynch + CIDR protocols (CIDR for 4 or 5 days, PGF α at CIDR removal and GnRH + TAI 72 h later). Twelve cycling Holstein heifers were randomly assigned to either the 4- or 5-day Co-Synch+CIDR (n = 6/treatment) to receive an intravaginal insert CIDR containing 1. Read More

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http://dx.doi.org/10.1002/vms3.171DOI Listing

Psychopathological disorders in Prader-Willi syndrome.

Endocrinol Diabetes Nutr 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Endocrinología y Nutrición, Hospital Universitari Parc Taulí, Universidad Autónoma de Barcelona, Sabadell (Barcelona), España. Electronic address:

Prader-Willi syndrome is a genetic disorder caused by chromosomal changes in segment 15q11-q13 including cognitive, mental, and behavioral symptoms, as well as a specific physical phenotype. Both the most common psychopathological changes (intellectual disability, obsessions, impulsivity, autism spectrum disorders, self-injuries) and the main psychiatric comorbidities (affective disorders, psychosis, obsessive-compulsive disorder, autism spectrum disorder) are characterized by a great heterogeneity, which warrants the need for better identification of their frequency and clinical signs. In addition to its effects on body compositionand hypotony, growth hormone has been shown to be useful for regulating patient behavior, and psychoactive drugs are also an option. Read More

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http://dx.doi.org/10.1016/j.endinu.2019.03.004DOI Listing

Impact of CFTR-modulating drugs on GH-IGF-1 axis impairment in adult patients with cystic fibrosis.

J Endocrinol Invest 2019 Apr 20. Epub 2019 Apr 20.

Section of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University of Rome, 00161, Rome, Italy.

Introduction: A new class of drugs in the treatment of cystic fibrosis (CF) includes two agents: lumacaftor, which corrects CFTR channel protein, and ivacaftor, which increases CFTR channel activity. In our previous study we recruited 50 stable adults with CF and 16 of them showed growth hormone deficit (GHD): 7 patients severe and 9 patients partial GHD.

Material And Methods: We decided to re-evaluate ten patients with the GHRH + arginine test of whom only five were treated with lumacaftor/ivacaftor. Read More

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http://dx.doi.org/10.1007/s40618-019-01051-4DOI Listing

Salicylic acid alleviates glyphosate-induced oxidative stress in Hordeum vulgare L.

J Environ Manage 2019 Apr 17;241:226-234. Epub 2019 Apr 17.

GreenUPorto - Centro de Investigação Em Produção Agroalimentar Sustentável, BiologyDepartment, FacultyofSciences, University of Porto, Rua Campo Alegre S/n, 4169-007, Porto, Portugal; Plant Stress Lab, Biology Department, Faculty of Sciences, University of Porto, Rua Campo Alegre S/n, 4169-007, Porto, Portugal.

Glyphosate (GLY) is considered the most used herbicide in the world and has been associated with several environmental contamination risks. Despite being partially degraded by soil microorganisms, its residues can negatively affect the growth of valuable non-target plants. Thus, there is a need to find new strategies that minimize its impacts and enhance crop tolerance to GLY, allowing a more advantageous and safer, use of this herbicide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797193049
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http://dx.doi.org/10.1016/j.jenvman.2019.04.035DOI Listing
April 2019
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Auxin and cell wall crosstalk as revealed by the Arabidopsis thaliana cellulose synthase mutant radially swollen 1.

Plant Cell Physiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Crop and Soil Sciences, Washington State University, Pullman, WA.

Plant cells sheath themselves in a complex lattice of polysaccharides, proteins, and enzymes forming an integral matrix known as the cell wall. Cellulose microfibrils, the primary component of cell walls, are synthesized at the plasma membrane by CELLULOSE SYNTHASE A (CESA) proteins throughout cellular growth and are responsible for turgor-driven anisotropic expansion. Associations between hormone signaling and cell wall biosynthesis have long been suggested, but recently direct links have been found revealing hormones play key regulatory roles in cellulose biosynthesis. Read More

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https://academic.oup.com/pcp/advance-article/doi/10.1093/pcp
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http://dx.doi.org/10.1093/pcp/pcz055DOI Listing
April 2019
6 Reads

Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.

Cancer Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery in Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai, China.

Nearly 75% of breast cancers are hormone receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-), making endocrine therapy the mainstay of treatment for HR+ and HER2- combination. Although endocrine therapy, such as therapy with fulvestrant, is widely used in the clinic, endocrine resistance (primary or secondary) is inevitable and poses a serious clinical concern. However, the therapeutic landscape of HR+/HER2- breast cancer is rapidly changing and evolving. Read More

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http://dx.doi.org/10.1002/cam4.2095DOI Listing

Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey.

Objective: Subclinical hypothyroidism, defined as increased TSH serum levels and normal serum free T4 concentrations, has been associated with an increased risk of heart disease in adults. But, data in children and adolescents are scanty and treatment of subclinical hypothyroidism is controversial. Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. Read More

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http://dx.doi.org/10.1007/s12020-019-01933-wDOI Listing

Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy.

Postgrad Med J 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Queen Mary Hospital, Hong Kong, China

Background: Over the last 10 years, there has been a major treatment revolution for early human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We aimed to explore the outcome of different neoadjuvant chemotherapy in a tertiary breast cancer centre with early HER2-positive breast cancer as well as factors associated with pathological complete response (pCR) and recurrence-free survival (RFS). The pattern of recurrence was also studied. Read More

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http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2018-1357
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http://dx.doi.org/10.1136/postgradmedj-2018-135739DOI Listing
April 2019
2 Reads

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos.

Pharmaceuticals (Basel) 2019 Apr 18;12(2). Epub 2019 Apr 18.

Postgraduate Program in-Network in Pharmaceutical Innovation, Federal University of Amapá, Macapá, AP 68902-280, Brazil.

(Linnaeus, 1762; Diptera: Culicidae) is the main vector transmitting viral diseases such as dengue fever, dengue haemorrhagic fever, urban yellow fever, zika and chikungunya. Worldwide, especially in the Americas and Brazil, many cases of dengue have been reported in recent years, which have shown significant growth. The main control strategy is the elimination of the vector, carried out through various education programs, to change human habits, but the most usual is biological control, together with environmental management and chemical control. Read More

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http://dx.doi.org/10.3390/ph12020061DOI Listing

Modulation of the somatotropic axis, adiponectin and cytokine secretion during highly pathogenic porcine reproductive and respiratory syndrome virus type 1 (HP-PRRSV-1) infection.

Res Vet Sci 2019 Apr 11;124:263-269. Epub 2019 Apr 11.

Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy.

Porcine reproductive and respiratory syndrome virus (PRRSV) is known to be clinically responsible for reproductive failure in sows and post-weaning respiratory disease in growing piglets. During the last years, highly pathogenic PRRSV isolates have been discovered. In Italy, a PRRSV-1 subtype 1 strain (namely PR40/2014) characterized by high pathogenicity was isolated and experimental infection was characterized in terms of virological/clinical features and immune modulation (Canelli et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183159
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http://dx.doi.org/10.1016/j.rvsc.2019.04.007DOI Listing
April 2019
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Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-00 Criciúma, SC, Brazil. Electronic address:

In the central nervous system, glial cells protect the brain against neuronal stress by inducing inflammatory responses; namely, intracellular signaling and cytokine production. However, chronic inflammation is often associated with degenerative diseases that can damage hormone signaling and mitochondrial function. Lipopolysaccharide (LPS) induces neuroinflammation by stimulating the production of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α); moreover, it generates oxidative stress and impairs cognitive functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183094
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.011DOI Listing
April 2019
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Vacuum Induced Surface Freezing for the Freeze-Drying of the Human Growth Hormone: How does Nucleation Control Affect Protein Stability?

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Standardisation Science, National Institute for Biological Standards and Control, Blanche Lane, Medicines & Healthcare products Agency, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK. Electronic address:

In the present work, the effect of controlled nucleation on the stability of human growth hormone (hGH) during freeze-drying has been investigated. More specifically, the vacuum induced surface freezing technique has been compared to conventional freezing, both with and without an annealing step. Size exclusion chromatography and cell-based potency assays have been used to characterize the formation of soluble aggregates and the biological activity of hGH, respectively. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.014DOI Listing

Growth hormone induces colon DNA damage independent of IGF-1.

Endocrinology 2019 Apr 19. Epub 2019 Apr 19.

Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

DNA damage occurs as a result of environmental insults and aging, and if unrepaired, may lead to chromosomal instability and tumorigenesis. As growth hormone (GH) suppresses ATM kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA damage are mediated through induced insulin-like growth factor (IGF)-1. In non-tumorous human colon cells, GH, but not IGF-1, enhanced DNA damage. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2019-00132DOI Listing
April 2019
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[Identification of mouse organ endogenous peptides by high throughput mass spectrometry].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):697-706

Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Endogenous peptides, in the form of cytokines, growth hormones and hormone peptides, play an important role in human hormones, nerves, cell growth and reproduction. Neuropeptide is a kind of endogenous peptide, which is related to the physiological activities of pain, sleep, emotion, learning and memory. Neuropeptides exist not only in the nerve cells of the brain, but also in other body fluids and organs. Read More

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http://www.cnki.net/kcms/doi/10.13345/j.cjb.180377.html
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http://dx.doi.org/10.13345/j.cjb.180377DOI Listing
April 2019
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Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.

Microbiologyopen 2019 Apr 18:e00810. Epub 2019 Apr 18.

Department of endocrinology and metabolism, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development. Read More

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http://dx.doi.org/10.1002/mbo3.810DOI Listing

High temperature and drought stress cause abscisic acid and reactive oxygen species accumulation and suppress seed germination growth in rice.

Protoplasma 2019 Apr 18. Epub 2019 Apr 18.

Collaborative Innovation Center of Henan Grain Crops, Henan Key Laboratory of Rice Biology, Henan Agricultural University, Zhengzhou, China.

Seed germination is one of the most important biological processes in the life cycle of plants, and temperature and water are the two most critical environmental factors that influence seed germination. In the present study, we investigated the roles of the plant hormone abscisic acid (ABA) and reactive oxygen species (ROS) in high temperature (HT) and drought-induced inhibition of rice seed germination. HT and drought stress caused ABA accumulation in seeds and inhibited seed germination and seedling establishment. Read More

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http://link.springer.com/10.1007/s00709-019-01354-6
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http://dx.doi.org/10.1007/s00709-019-01354-6DOI Listing
April 2019
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Pituitary Disease in Pregnancy: Special Aspects of Diagnosis and Treatment?

Geburtshilfe Frauenheilkd 2019 Apr 6;79(4):365-374. Epub 2019 Mar 6.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany.

The diagnosis and treatment of pituitary disease in pregnancy represents a special clinical challenge. Not least because there is very little data on the treatment of pregnant patients with pituitary disorders. A selective search of the literature was carried out with the aim of compiling evidence about the diagnosis and treatment of pituitary disease in pregnancy. Read More

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http://dx.doi.org/10.1055/a-0794-7587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461462PMC
April 2019
1 Read

Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth.

Cell Death Dis 2019 Apr 18;10(5):339. Epub 2019 Apr 18.

George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and The Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, 14642, USA.

Recent studies have demonstrated that the androgen receptor (AR) could play important roles to promote renal cell carcinoma (RCC) cell proliferation, and other studies have also indicated that suppressing the argininosuccinate synthase 1 (ASS1) could promote proliferation of various tumors. The potential of AR promoting cell proliferation in RCC via altering ASS1, however, remains unclear. Here we found that the expression of ASS1 was lower in RCC tissues than in adjacent normal renal tissues, and a lower ASS1 expression was linked to a worse prognosis in RCC patients. Read More

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http://dx.doi.org/10.1038/s41419-019-1330-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472417PMC
April 2019
5.014 Impact Factor

Puberty: Normal physiology (brief overview).

Best Pract Res Clin Endocrinol Metab 2019 Mar 30. Epub 2019 Mar 30.

Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK; Great North Children's Hospital, Royal Victoria Infirmary, Queen Victoria Road, Newcastle Upon Tyne, NE1 4LP, UK. Electronic address:

Puberty is a defining phase of human development where growth ends and the ability to reproduce begins. An understanding of the events leading up to puberty highlights the fact that this is the culmination of a process of skeletal and gonadal activity that has been ongoing since conception. Although there is natural variation in the timing of events in and around puberty the basic underlying processes are common to all healthy human beings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1521690X193000
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http://dx.doi.org/10.1016/j.beem.2019.03.001DOI Listing
March 2019
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The regulation of circadian clock by tumor necrosis factor alpha.

Cytokine Growth Factor Rev 2019 Apr 2. Epub 2019 Apr 2.

ALTAY Biopharma, San Bruno, CA, USA. Electronic address:

All organisms display circadian rhythms which are under the control of the circadian clock located in the hypothalamus at the suprachiasmatic nucleus, (SCN). The circadian rhythms allow individuals to adjust their physiological activities and daily behavior for the diurnal changes in the living environment. To achieve these, all metabolic processes are aligned with the sleep/wake and fasting/feeding cycles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13596101193001
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http://dx.doi.org/10.1016/j.cytogfr.2019.04.001DOI Listing
April 2019
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Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation.

Eur J Vasc Endovasc Surg 2019 Apr 15. Epub 2019 Apr 15.

Kidney Research Institute, University of Washington, Seattle, WA, USA.

Background: The arteriovenous fistula (AVF) is central to haemodialysis treatment, but up to half of surgically created AVF fail to mature. Chronic kidney disease often leads to mineral metabolism disturbances that may interfere with AVF maturation through adverse vascular effects. This study tested associations between mineral metabolism markers and vein histology at AVF creation and unassisted and overall clinical AVF maturation. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.01.022DOI Listing

Identification and Characterization of Salt-Responsive MicroRNAs in by High-Throughput Sequencing.

Genes (Basel) 2019 Apr 17;10(4). Epub 2019 Apr 17.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Salt stress has detrimental effects on plant growth and development. MicroRNAs (miRNAs) are a class of noncoding RNAs that are involved in post-transcriptional gene expression regulation. In this study, small RNA sequencing was employed to identify the salt stress-responsive miRNAs of the salt-sensitive Hassawi-3 and the salt-tolerant ILB4347 genotypes of faba bean, growing under salt stress. Read More

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https://www.mdpi.com/2073-4425/10/4/303
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http://dx.doi.org/10.3390/genes10040303DOI Listing
April 2019
2 Reads

Differential expression of androgen receptor variants in hormone-sensitive prostate cancer xenografts, castration-resistant sublines, and patient specimens according to the treatment sequence.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Androgen receptor variants (AR-vs), especially AR-v7 and AR-v 5, 6, and 7 exon-skipped (AR-v567es), are reportedly key players in the development of castration-resistant prostate cancer (CRPC). We previously established a mouse xenograft model (JDCaP) from a metastatic skin lesion from a Japanese patient with CRPC and that was revealed to exhibit androgen sensitivity. In the present study, we established multiple castration-resistant xenograft models from JDCaP mice to investigate the biological features of CRPC. Read More

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http://dx.doi.org/10.1002/pros.23816DOI Listing

[Specific cases of slipped capital femoral epiphysis : Endocrinopathies, hormone therapy and other rare causes].

Orthopade 2019 Apr 17. Epub 2019 Apr 17.

Orthopädische Klinik, Olgahospital, Klinikum Stuttgart, Kriegsbergstr. 62, 70174, Stuttgart, Deutschland.

In slipped capital femoral epiphysis (SCFE) atypical causes can be found in about 5% of cases. The patients' age differs from the typical age of SCFE patients of between age 10 and 16. There are numerous causes of atypical SCFE: different endocrine disorders, sequelae of chronic renal failure and effects of radiation and chemotherapy on the proximal femoral physis. Read More

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http://dx.doi.org/10.1007/s00132-019-03728-3DOI Listing
April 2019
1 Read

[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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April 2019
2 Reads

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.

J Biol Chem 2019 Apr 17. Epub 2019 Apr 17.

University of Illinois at Urbana-Champaign, United States.

The bile acid (BA) nuclear receptor, farnesoid X receptor (FXR/NR1H4), maintains metabolic homeostasis by transcriptional control of numerous genes, including an intestinal hormone fibroblast growth factor-19 (FGF19, FGF15 in mouse). Besides, activation by BAs, the gene-regulatory function of FXR is also modulated by hormone or nutrient signaling-induced posttranslational modifications. Recently, phosphorylation at Tyr-67 by the FGF15/19 signaling-activated nonreceptor tyrosine kinase Src was shown to be important for FXR function in BA homeostasis. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.008360
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http://dx.doi.org/10.1074/jbc.RA119.008360DOI Listing
April 2019
1 Read

Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy.

Cell Rep 2019 Apr;27(3):730-736.e3

Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel. Electronic address:

Gestation is accompanied by alterations in the microbial repertoire; however, the mechanisms driving these changes are unknown. Here, we demonstrate a dramatic shift in the gut microbial composition of women and mice during late pregnancy, including an increase in the relative abundance of Bifidobacterium. Using in-vivo-transplanted pellets, we found that progesterone, the principal gestation hormone, affects the microbial community. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193040
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http://dx.doi.org/10.1016/j.celrep.2019.03.075DOI Listing
April 2019
3 Reads

MANAGEMENT AND OUTCOMES OF GIANT PROLACTINOMA: A SERIES OF 71 PATIENTS.

Endocr Pract 2019 Apr;25(4):340-352

To describe outcomes of patients with giant prolactinoma (≥4 cm) and identify predictors of therapeutic response. In this retrospective study, complete biochemical and structural response were defined as prolactin (PRL) ≤25 ng/mL and no visible tumor at follow-up, respectively. Giant prolactinoma (median size, 4. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0392
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http://dx.doi.org/10.4158/EP-2018-0392DOI Listing
April 2019
2 Reads

The effects of parathyroid hormone-related peptide on cardiac angiogenesis, apoptosis, and function in mice with myocardial infarction.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

It is known that parathyroid hormone-related peptide (PTHrP) contains a nuclear localization sequence (NLS, 87-107), which, together with its C-terminus (107-139), has been shown to positively regulate vascular smooth muscle cell (VSMCs) proliferation and vascular neointima formation, and inhibit cellular apoptosis. The role of PTHrP in ischemic cardiac diseases remains unclear. In this study, we attempted to determine whether PTHrP 87 to 139 can play a role in promoting cardiac function via enhancing angiogenesis after myocardial infarction (MI) occurred. Read More

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http://dx.doi.org/10.1002/jcb.28735DOI Listing

Maternal heavy metal exposure, thyroid hormones, and birth outcomes: a prospective cohort study.

J Clin Endocrinol Metab 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, China.

Context: Maternal thyroid hormones during pregnancy play a critical role in fetal development. However, whether maternal heavy metal exposure affects their thyroid hormones and the effects on fetal growth are still unclear.

Objective: To explore the impact of heavy metal exposure on maternal thyroid hormones and the potential mediation role of thyroid hormones on birth outcomes. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02492DOI Listing
April 2019
2 Reads

Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells.

Braz J Med Biol Res 2019 15;52(4):e7728. Epub 2019 Apr 15.

Department of Pain Clinic, The First Affiliated Hospital of Xiamen University, Fujian Medical University, Xiamen, Fujian, China.

Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell transfection and qRT-PCR were used to change and measure the expression levels of HULC, miR-130b, and FOXM1. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20197728DOI Listing
April 2019
1 Read

The effects of training on hormonal concentrations in young soccer players.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Dipartimento di Scienze e Tecnologie Biologiche e Ambientali (Di.S.Te.B.A.), Università del Salento, Lecce, Italy.

To test the hypothesis that football training would be accompanied by physiological adaptations and hormonal changes, we analyzed the effects of a whole football season on physical fitness and hormonal concentrations in youth football players. Male football players (n = 29, age 16.51 ± 0. Read More

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http://dx.doi.org/10.1002/jcp.28673DOI Listing

Hormone Receptors and Human Epidermal Growth Factor (HER2) Expression in Fine-Needle Aspirates from Metastatic Breast Carcinoma - Role in Patient Management.

J Cytol 2019 Apr-Jun;36(2):94-100

Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait.

Introduction: Estrogen receptors (ER), progesterone receptors (PR), and epidermal growth factor (HER2) are prognostic and predictive factors for breast carcinoma. We determined them by immunohistochemistry (IHC) on cell blocks from fine-needle aspirates (FNA) of metastatic breast carcinoma to axillary lymphnodes and compared them with that reported in the primary breast carcinoma (PBC) to document any change in their expression for future management.

Materials And Methods: ER, PR, and HER2 by IHC and HER2 oncogene by fluorescent in-situ hybridization (FISH) were studied on cell blocks of FNA of axillary lymphnodes in 53 of 94 PBC cases from 2012 to 2016. Read More

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http://dx.doi.org/10.4103/JOC.JOC_117_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425780PMC
April 2019
1 Read

Effects of dietary Radix Rehmanniae Preparata polysaccharides on the growth performance, immune response and disease resistance of Luciobarbus capito.

Fish Shellfish Immunol 2019 Apr 13;89:641-646. Epub 2019 Apr 13.

Suqian Institute of Agricultural Sciences, Jiangsu Academy of Agricultural Sciences, Suqian, 223800, China. Electronic address:

This work explores the effects of dietary Radix Rehmanniae Preparata polysaccharide (RRPP) supplementation on the growth performance, nonspecific immune responses, immune- and growth-related gene expression and disease resistance to Aeromonas hydrophila in Luciobarbus capito. Diets containing five concentrations of 0%, 0.05%, 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193026
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http://dx.doi.org/10.1016/j.fsi.2019.04.027DOI Listing
April 2019
2 Reads

Anatomical assessment of the adult skeleton of zebrafish reared under different thyroid hormone profiles.

Anat Rec (Hoboken) 2019 Apr 15. Epub 2019 Apr 15.

Department of Biological Sciences, The George Washington University, Science and Engineering Hall, 800 22nd Street NW, Suite 6000, Washington, DC 20052.

Thyroid hormone (TH) directs the growth and maintenance of tissues throughout the body during development and into adulthood, and plays a particularly important role in proper ossification and homeostasis of the skeleton. To better understand the roles of TH in the skeletogenesis of a vertebrate model, and to define areas of the skeleton that are particularly sensitive to developmental TH, we examined the effects of hypo- and hyperthyroidism on skeletal development in zebrafish. Performing a bone-by-bone anatomical assessment on the entire skeleton of adult fish, we found that TH is required for proper ossification, growth, morphogenesis, and fusion of numerous bones. Read More

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http://dx.doi.org/10.1002/ar.24139DOI Listing

Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis.

Mol Ther Methods Clin Dev 2019 Jun 14;13:344-358. Epub 2019 Mar 14.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.

Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder causing endocrine, musculoskeletal, and neurological dysfunction. PWS is caused by the inactivation of contiguous genes, complicating the development of targeted therapeutics. Clinical trials are now underway in PWS, with more trials to be implemented in the next few years. Read More

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http://dx.doi.org/10.1016/j.omtm.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447752PMC
June 2019
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Analysis of the value and correlation of IGF-1 with GH and IGFBP-3 in the diagnosis of dwarfism.

Exp Ther Med 2019 May 13;17(5):3689-3693. Epub 2019 Mar 13.

Department of Pediatrics, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu 214000, P.R. China.

Correlation between the value of insulin-like growth factor-1 (IGF-1) in the diagnosis of dwarfism and the levels of growth hormone (GH) and insulin-like growth factor binding protein-3 (IGFBP-3) was investigated. From April 2014 to June 2017, 122 children with dwarfism who were treated in The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University and The First Affiliated Hospital of Xinxiang Medical University were selected as the experimental group, and 51 normal children as the control group. Read More

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http://dx.doi.org/10.3892/etm.2019.7393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447816PMC
May 2019
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PDGFRα stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.

Nat Commun 2019 Apr 15;10(1):1760. Epub 2019 Apr 15.

Princess Margaret Cancer Centre, Toronto, ON, M5G 1L7, Canada.

The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the stroma that may directly contribute to epithelial biology is unknown. Here we identify, in mouse, the transition of a PDGFRα mesenchymal cell population into mammary epithelial progenitors. Read More

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http://dx.doi.org/10.1038/s41467-019-09748-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465250PMC

Identification of a Novel PROP1 Mutation in a Patient with Combined Pituitary Hormone Deficiency and Enlarged Pituitary.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy.

Growth hormone deficiency (GHD) can be present from the neonatal period to adulthood and can be the result of congenital or acquired insults. In addition, GHD can be classified into two types: isolated growth hormone deficiency (IGHD) and combined pituitary hormone deficiency (CPHD). CPHD is a disorder characterized by impaired production of two or more anterior and/or posterior pituitary hormones. Read More

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http://dx.doi.org/10.3390/ijms20081875DOI Listing
April 2019
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Anaerobic Performance after a Low-Carbohydrate Diet (LCD) Followed by 7 Days of Carbohydrate Loading in Male Basketball Players.

Nutrients 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Mikolowska 72a, 40-065 Katowice, Poland.

Despite increasing interest among athletes and scientists on the influence of different dietary interventions on sport performance, the association between a low-carbohydrate, high-fat diet and anaerobic capacity has not been studied extensively. The aim of this study was to evaluate the effects of a low-carbohydrate diet (LCD) followed by seven days of carbohydrate loading (Carbo-L) on anaerobic performance in male basketball players. Fifteen competitive basketball players took part in the experiment. Read More

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http://dx.doi.org/10.3390/nu11040778DOI Listing

Efficiency of CIDR-Based Protocols Including GnRH Instead of eCG for Estrus Synchronization in Sheep.

Animals (Basel) 2019 Apr 3;9(4). Epub 2019 Apr 3.

Dpto. de Reproduccion Animal, INIA, Avda. Puerta de Hierro s/n., 28040-Madrid, Spain.

The present study examined, for meat sheep (Segureña breed; 2-5-years old, mean body score of 3.5 ± 0.5), the timings of onset of estrus behavior, preovulatory luteinizing hormone (LH) surge and ovulation, and the ovulation rate and fertility obtained after insertion of controlled internal drug release (CIDR) devices for 5 days plus treatment with equine chorionic gonadotrophin (eCG; single dose at CIDR removal, n = 19 ewes) or gonadotrophin-releasing hormone (GnRH, either in a single dose at 56 h after CIDR removal, group CIDR-GnRH, n = 19 ewes; or in one dose at CIDR insertion and another dose 56 h after CIDR removal, group GnRH-CIDR-GnRH, n = 19 ewes). Read More

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http://dx.doi.org/10.3390/ani9040146DOI Listing
April 2019
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Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in : Insights from Molecular Dynamics Simulations.

Biomolecules 2019 Apr 3;9(4). Epub 2019 Apr 3.

Institute of Biochemistry and Biotechnology, Quaid-e-Azam Campus, University of the Punjab, Opp. Sheikh Zaid Hospital, Canal Bank Road, Lahore 54590, Pakistan.

The disulfide bond signal sequence (DsbAss) protein is characterized as an important virulence factor in gram-negative bacteria. This study aimed to analyze the "alanine" alteration in the hydrophobic (H) region of DsbAss and to understand the conformational DsbAss alteration(s) inside the fifty-four homolog (Ffh)-binding groove which were revealed to be crucial for translocation of ovine growth hormone (OGH) to the periplasmic space in via the secretory (Sec) pathway. An experimental design was used to explore the hydrophobicity and alteration of alanine (Ala) to isoleucine (Ile) in the tripartite structure of DsbAss. Read More

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http://dx.doi.org/10.3390/biom9040133DOI Listing

Benzene affects the response to octreotide treatment of growth hormone secreting pituitary adenoma cells.

Environ Res 2019 Apr 8;173:489-496. Epub 2019 Apr 8.

Division of Oncological Endocrinology, Città della Salute e della Scienza University Hospital, I-10126, Turin, Italy. Electronic address:

Growth hormone (GH) secreting pituitary adenomas are the main cause of acromegaly. Somatostatin analogs are the gold standard of medical therapy; however, resistance represents a big drawback in acromegaly management. We recently demonstrated that benzene (BZ) modifies the aggressiveness of GH-secreting rat pituitary adenoma cells (GH3), increasing GH secretion and altering the synthesis of molecules involved in the somatostatin signaling pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193021
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http://dx.doi.org/10.1016/j.envres.2019.04.007DOI Listing
April 2019
2 Reads