124,660 results match your criteria Growth Hormone & IGF Research [Journal]


West German Study PlanB Trial: Adjuvant Four Cycles of Epirubicin and Cyclophosphamide Plus Docetaxel Versus Six Cycles of Docetaxel and Cyclophosphamide in HER2-Negative Early Breast Cancer.

J Clin Oncol 2019 Feb 20:JCO1800028. Epub 2019 Feb 20.

1 West German Study Group, Mönchengladbach, Germany.

Purpose: The West German Study Group PlanB trial evaluated an anthracycline-free chemotherapy standard (six cycles of docetaxel and cyclophosphamide [TC]) in the routine treatment of human epidermal growth factor receptor 2-negative early breast cancer (EBC).

Patients And Methods: Patients with pT1 to pT4c, all pN+, and pN0/high-risk EBC were eligible. High-risk pN0 was defined by one or more of the following: pT greater than 2, grade 2 to 3, high urokinase-type plasminogen activator/plasminogen activator inhibitor-1, hormone receptor (HR) negativity, and less than 35 years of age. Read More

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http://dx.doi.org/10.1200/JCO.18.00028DOI Listing
February 2019

Treatment patterns, clinical outcomes, health resource utilization, and cost in patients with BRCA-mutated metastatic breast cancer treated in community oncology settings.

Cancer Treat Res Commun 2019 Feb 6;19:100121. Epub 2019 Feb 6.

West Cancer Center, 7945 Wolf River Boulevard, Germantown, TN 38138, United States.

Purpose: This retrospective study of community oncology patients with breast cancer gene (BRCA)-mutated metastatic breast cancer (MBC) examined treatment outcomes and health resource utilization (HRU) and costs for a sample of patients with human epidermal growth factor receptor 2 (HER2)-negative disease who were either hormone receptor positive (HR+) or triple negative breast cancer (TNBC).

Methods: Evidence from the Vector Oncology Data Warehouse, a repository of electronic medical records/billing data and provider notes, was analyzed. Treatment outcomes were progression-free survival (PFS) and overall survival (OS) from start of first-line therapy in the metastatic setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24682942183013
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http://dx.doi.org/10.1016/j.ctarc.2019.100121DOI Listing
February 2019
6 Reads

Effects of cytokinins, gibberellic acid 3, and gibberellic acid 4/7 on in vitro growth, morphological traits, and content of steviol glycosides in Stevia rebaudiana.

Plant Physiol Biochem 2019 Feb 12;137:154-161. Epub 2019 Feb 12.

Department of Biology, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey. Electronic address:

Steviol glycosides (SGs) and gibberellic acids share a part of their biosynthesis pathways. Despite the widespread studies on the effect of gibberellic acid 3 (GA), the effect of gibberellic acid 4 and 7 (GA) on Stevia rebaudiana has never been studied. This study aimed at a comparative evaluation of different hormone effects, i. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.02.009DOI Listing
February 2019

Responsiveness of swine divergently selected for feed efficiency to exogenous adrenocorticotropic hormone and glucose challenges.

Domest Anim Endocrinol 2018 Dec 28;68:32-38. Epub 2018 Dec 28.

Department of Animal Science, Iowa State University, Ames, IA 50011, USA.

Increasing the feed efficiency of lean tissue gains is an important goal for improving sustainable pork production and profitability for swine producers. To study feed efficiency, genetic selection based on residual feed intake (RFI) was used to create two divergent lines. Low-RFI pigs consume less feed for equal weight gain compared with their less-efficient, high-RFI counterparts. Read More

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http://dx.doi.org/10.1016/j.domaniend.2018.12.007DOI Listing
December 2018

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.

Diabetes Obes Metab 2019 Feb 19. Epub 2019 Feb 19.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Institute of Experimental Pediatric Endocrinology, Berlin, Germany.

Aims: Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that augments insulin secretion in pancreatic β-cells via its glucose-dependent insulinotropic polypeptide receptor (GIPR). Recent genome-wide association studies identified a single nucleotide variant (SNV) in the GIPR encoding gene (GIPR), rs1800437, that is associated with obesity and insulin resistance. In the present study, we tested whether GIPR variants contribute to obesity and disturb glucose homeostasis or diabetes in specific patient populations. Read More

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http://dx.doi.org/10.1111/dom.13634DOI Listing
February 2019

The impact of EndoPredict on decision making with increasing oncological work experience: can overtreatment be avoided?

Arch Gynecol Obstet 2019 Feb 19. Epub 2019 Feb 19.

Breast Cancer Center, Municipal Hospital Holweide, Cologne, Germany.

Background: Estimating distant recurrence risk in women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer is still challenging. EndoPredict is a gene expression-based test predicting the likelihood of recurrent disease. We analyzed the difference in oncological decision making with and without the knowledge of gene expression tests. Read More

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http://dx.doi.org/10.1007/s00404-019-05097-wDOI Listing
February 2019

Proteolytic processing of SERK3/BAK1 regulates plant immunity, development and cell death.

Plant Physiol 2019 Feb 19. Epub 2019 Feb 19.

Texas A&M University CITY: college station STATE: Texas POSTAL_CODE: 77843 United States Of America [US]

Plants have evolved many receptor-like kinases (RLKs) to sense extrinsic and intrinsic cues. The signaling pathways mediated by multiple leucine-rich repeat (LRR) RLK (LRR-RLK) receptors require ligand-induced receptor-coreceptor heterodimerization and transphosphorylation with BAK1/SERK family LRR-RLKs. Here we reveal an additional layer of regulation of BAK1 via a Ca2+-dependent proteolytic cleavage process that is conserved in Arabidopsis thaliana, Nicotiana benthamiana and Saccharomyces cerevisiae . Read More

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http://dx.doi.org/10.1104/pp.18.01503DOI Listing
February 2019

Testosterone and growth hormone in older men: for better or for worse?

Authors:
Bu B Yeap

Expert Rev Endocrinol Metab 2009 Jul;4(4):321-323

a School of Medicine and Pharmacology, University of Western Australia and Department of Endocrinology and Diabetes, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia.

Evaluation of: Sattler FR, Castaneda-Sceppa C, Binder EF et al. Testosterone and growth hormone improve body composition and muscle performance in older men. J. Read More

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http://dx.doi.org/10.1586/eem.09.15DOI Listing

Pituitary dysfunction after traumatic brain injury: screening and hormone replacement.

Expert Rev Endocrinol Metab 2011 Sep;6(5):697-703

a Department of Endocrinology and Metabolism, University of Texas Medical Branch, Galveston, TX, USA.

This article highlights the risk of hypopituitarism in survivors of traumatic brain injury (TBI), an underdiagnosed clinical problem. Clinical evidence shows that anterior pituitary dysfunction is common in TBI survivors evaluated at least 6 months after the TBI, with an estimated prevalence of up to 27.5%. Read More

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http://dx.doi.org/10.1586/eem.11.59DOI Listing
September 2011

Is prolactin involved in the evolution of atherothrombotic disease?

Expert Rev Endocrinol Metab 2012 May;7(3):345-361

f INSERM, Unit 845, Faculty of Medicine, Research Center in Growth and Signaling, Team 'PRL/GH Pathophysiology', University Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Necker, Paris, France.

Cardiovascular diseases (CVDs) account for approximately 30% of all deaths globally. The most important cause of CVD is atherothrombosis, in other words, narrowing of the arteries as a result of the deposition of cholesterol and other lipoid substances within the arterial wall. Several endocrine disorders have been linked to this pathological state. Read More

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http://dx.doi.org/10.1586/eem.12.23DOI Listing

Mechanisms and management of growth impairment in children affected by inflammatory bowel disease.

Expert Rev Endocrinol Metab 2013 May;8(3):289-299

a Department of Pediatrics, University of Milan, Luigi Sacco Hospital, Milan, Italy.

Growth failure is a typical complication of pediatric inflammatory bowel disease. Factors responsible for stunting are multiple, and proinflammatory cytokines such as TNF-α and IL-6 play a pivotal role. Other determinants are disease severity and location, malnutrition, increased nutritional needs, genetics and drugs. Read More

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http://dx.doi.org/10.1586/eem.13.12DOI Listing

Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging.

Int J Environ Res Public Health 2019 Feb 13;16(4). Epub 2019 Feb 13.

Respiratory Medicine Department, University of Thessaly Medical School, University Hospital of Larisa, 41110 Larissa, Greece.

(1) Background: Chronic obstructive pulmonary disease (COPD) is defined as an inflammatory disorder that presents an increasingly prevalent health problem. Accelerated aging has been examined as a pathologic mechanism of many chronic diseases like COPD. We examined whether COPD is combined with accelerated aging, studying two hormones, dehydroepiandrosterone (DHEA) and growth hormone (GH), known to be characteristic biological markers of aging. Read More

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http://www.mdpi.com/1660-4601/16/4/540
Publisher Site
http://dx.doi.org/10.3390/ijerph16040540DOI Listing
February 2019
2 Reads

Identification of Differentially Expressed Genes and Pathways for Abdominal Fat Deposition in Ovariectomized and Sham-Operated Chickens.

Genes (Basel) 2019 Feb 18;10(2). Epub 2019 Feb 18.

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Ovariectomy results in improved meat quality (growth rate, tenderness, and flavor) of broilers. However, some negative effects increased (abdominal fat (AF) deposition, low feed conversion, etc.) have also been reported. Read More

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http://dx.doi.org/10.3390/genes10020155DOI Listing
February 2019

Cell-Free DNA Variant Sequencing Using CTC-Depleted Blood for Comprehensive Liquid Biopsy Testing in Metastatic Breast Cancer.

Cancers (Basel) 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of Gynecology and Obstetrics, University Hospital of Essen, 45122 Essen, Germany.

Liquid biopsy analytes such as cell-free DNA (cfDNA) and circulating tumor cells (CTCs) exhibit great potential for personalized treatment. Since cfDNA and CTCs are considered to give additive information and blood specimens are limited, isolation of cfDNA and CTC in an "all from one tube" format is desired. We investigated whether cfDNA variant sequencing from CTC-depleted blood (CTC-depl. Read More

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http://dx.doi.org/10.3390/cancers11020238DOI Listing
February 2019

Echinacoside Isolated from Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor.

Molecules 2019 Feb 17;24(4). Epub 2019 Feb 17.

Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, Taiwan.

species, the ginseng of the desert, has been recorded to possess many biological activities in traditional Chinese pharmacopoeia and has been used as an anti-aging medicine. Three phenylethanoid glycosides-echinacoside, tubuloside A, and acteoside-were detected in the water extract of (Schenk) R. Wight and the major constituent, echinacoside, was further purified. Read More

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http://dx.doi.org/10.3390/molecules24040720DOI Listing
February 2019

The Role of the Late Embryogenesis-Abundant (LEA) Protein Family in Development and the Abiotic Stress Response: A Comprehensive Expression Analysis of Potato ().

Genes (Basel) 2019 Feb 15;10(2). Epub 2019 Feb 15.

School of Life Science, Yunnan Normal University, Kunming 650550, China.

Late embryogenesis-abundant (LEA) proteins are a large and highly diverse family believed to function in normal plant growth and development, and in protecting cells from abiotic stress. This study presents a characterisation of 74 LEA (StLEA) proteins belonging to nine groups. genes have few introns (≤2) and are distributed on all chromosomes, occurring as gene clusters on chromosomes 1, 2, and 10. Read More

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http://dx.doi.org/10.3390/genes10020148DOI Listing
February 2019

Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.

FASEB J 2019 Feb 19:fj201802328R. Epub 2019 Feb 19.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Growth hormone (GH) has an important function as an insulin antagonist with elevated insulin sensitivity evident in humans and mice lacking a functional GH receptor (GHR). We sought the molecular basis for this sensitivity by utilizing a panel of mice possessing specific deletions of GHR signaling pathways. Metabolic clamps and glucose homeostasis tests were undertaken in these obese adult C57BL/6 male mice, which indicated impaired hepatic gluconeogenesis. Read More

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http://dx.doi.org/10.1096/fj.201802328RDOI Listing
February 2019

Effects of dietary taurine supplementation on growth performance, jejunal morphology, appetite-related hormones, and genes expression in broilers subjected to chronic heat stress.

Poult Sci 2019 Feb 19. Epub 2019 Feb 19.

College of Animal Science and Technology; Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province; Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, Nanjing 210095, P. R. China.

This study was aimed to elucidate effects of taurine supplementation on growth performance, jejunal histology, and appetite-related genes expressions of broilers under heat stress. A total of 144 broilers on 28 d were allocated to three groups with 6 cages each group, 8 broilers per cage. The experiment period is from 28 to 42 d of age. Read More

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http://dx.doi.org/10.3382/ps/pez054DOI Listing
February 2019

The apocarotenoid metabolite zaxinone regulates growth and strigolactone biosynthesis in rice.

Nat Commun 2019 Feb 18;10(1):810. Epub 2019 Feb 18.

Division of Biological and Environmental Science and Engineering, the BioActives Lab, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.

Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit retarded growth and showed elevated levels of strigolactones (SLs), a hormone that determines plant architecture, mediates mycorrhization and facilitates infestation by root parasitic weeds, such as Striga spp. Read More

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http://dx.doi.org/10.1038/s41467-019-08461-1DOI Listing
February 2019

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro.

BMC Cancer 2019 Feb 18;19(1):158. Epub 2019 Feb 18.

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, 97331, USA.

Background: Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utilizing autocrine and/or paracrine hormones as growth factors and/or promoters of angiogenesis to facilitate progression and metastasis. While many of these factors and their actions on tumor growth are characterized, some tumor-derived neuropeptides remain unexplored. Read More

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http://dx.doi.org/10.1186/s12885-019-5363-4DOI Listing
February 2019

Quantitative Auxin Metabolite Profiling Using Stable Isotope Dilution UHPLC-MS/MS.

Curr Protoc Plant Biol 2016 Mar;1(2):419-430

Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.

Auxin, a plant hormone, is able to stimulate growth and to control developmental processes. To get a deeper level of understanding of how auxin activity is regulated in planta, we have developed a sensitive and selective mass spectrometry-based protocol for multiplex quantification of indole 3-acetic acid (IAA) as well as its precursors and degradation products. As part of the protocol development, we have also established a derivatization protocol for the IAA precursors IPyA and IAAld, compounds that are highly labile during sample extraction and purification. Read More

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http://dx.doi.org/10.1002/cppb.20028DOI Listing

The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia.

Osteoporos Sarcopenia 2016 Sep 21;2(3):140-155. Epub 2016 Jul 21.

Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, South Korea.

Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones can interact with different signaling pathways through their receptors. Read More

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http://dx.doi.org/10.1016/j.afos.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372754PMC
September 2016

Genome-wide analysis of developmental stage-specific transcriptome in Bradysia odoriphaga.

Comp Biochem Physiol Part D Genomics Proteomics 2019 Feb 10;30:45-54. Epub 2019 Feb 10.

Institute of Plant Protection and Agro-Products Safety, Anhui Academy of Agricultural Sciences, Hefei 230031, Anhui Province, China. Electronic address:

Bradysia odoriphaga is a serious pest of the Chinese chive; however, detailed information regarding the developmental stage-specific gene expression patterns of B. odoriphaga is not yet available. In this study, RNA sequencing (RNA-seq) was performed to determine the gene expression patterns of developmental stages including the eggs, second instar larvae, fourth instar larvae, pupae, and adults of B. Read More

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http://dx.doi.org/10.1016/j.cbd.2019.02.003DOI Listing
February 2019

Is plastic ingestion in birds as toxic as we think? Insights from a plastic feeding experiment.

Sci Total Environ 2019 Feb 13;665:660-667. Epub 2019 Feb 13.

Institute for Marine and Antarctic Studies, University of Tasmania, Hobart, Tasmania, Australia; Antarctic Climate and Ecosystems CRC, University of Tasmania, Hobart, Tasmania, Australia.

Plastic pollution is a modern tragedy of the commons, with hundreds of species affected by society's waste. Birds in particular mistake plastic for prey, and millions of wild birds carry small plastic loads in their stomach and are exposed to potential toxicological effects. It is currently unknown how severely the toxicological and endocrine disrupting chemicals in plastic affect avian development, reproduction and endocrine function. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.184DOI Listing
February 2019

Left Ventricular Structure in Patients With Mild-to-Moderate CKD-a Magnetic Resonance Imaging Study.

Kidney Int Rep 2019 Feb 11;4(2):267-274. Epub 2018 Oct 11.

Department of Nephrology and Hypertension, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

Introduction: The high burden of left ventricular (LV) abnormalities in patients with advanced chronic kidney disease (CKD) is well established. However, less is known about the prevalence, patterns, and determinants of LV abnormalities in patients with early CKD.

Methods: We examined LV structure in 290 patients with a median estimated glomerular filtration rate (eGFR) of 51 ml/min per 1. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365352PMC
February 2019

Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.

Sci Adv 2019 Feb 6;5(2):eaav5590. Epub 2019 Feb 6.

Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.

Breast cancer (BC) resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor α (ERα) signaling, and ways to block ERα pathway in these tumors are sought after. We identified the H3K79 methyltransferase DOT1L as a novel cofactor of ERα in BC cell chromatin, where the two proteins colocalize to regulate estrogen target gene transcription. DOT1L blockade reduces proliferation of hormone-responsive BC cells in vivo and in vitro, consequent to cell cycle arrest and apoptotic cell death, with widespread effects on ER-dependent gene transcription, including ERα and FOXA1 gene silencing. Read More

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http://dx.doi.org/10.1126/sciadv.aav5590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365116PMC
February 2019

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier.

Asian J Urol 2019 Jan 15;6(1):57-64. Epub 2018 Sep 15.

Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.

Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa). However, this approach is rarely curative. Recent clinical trials have demonstrated that ADT combined with other agents, notably docetaxel and abiraterone, lead to improved survival. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363606PMC
January 2019

Targeting growth hormone function: strategies and therapeutic applications.

Signal Transduct Target Ther 2019 8;4. Epub 2019 Feb 8.

1Liggins Institute, University of Auckland, Auckland, New Zealand.

Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for normal postnatal growth and has pleiotropic effects across multiple physiological systems. GH is also expressed in extrapituitary tissues and has localized autocrine/paracrine effects at these sites. In adults, hypersecretion of GH causes acromegaly, and strategies that block the release of GH or that inhibit GH receptor (GHR) activation are the primary forms of medical therapy for this disease. Read More

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http://dx.doi.org/10.1038/s41392-019-0036-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367471PMC
February 2019

Effect of insulin or insulin-like growth factor-I administration at mid-luteal phase of the estrous cycle during superovulation on hormonal profile of Sahiwal cows.

Vet World 2018 Dec 27;11(12):1736-1741. Epub 2018 Dec 27.

Department of Veterinary Gynaecology and Obstetrics, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India.

Aim: The present study was designed to study the effect of insulin and insulin-like growth factor-1 (IGF-I) administration during luteal phase of the estrous cycle on the hormonal profile of Sahiwal embryo donor cows during superovulation.

Materials And Methods: Cows (n=18) were selected and divided into three groups; control (n=6, untreated), T-I (n=6, insulin-treated), and T-II (n=6, IGF-I treated). Insulin and IGF-I were given S/C on 5, 6, 7, and 8 days of estrous cycle. Read More

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http://dx.doi.org/10.14202/vetworld.2018.1736-1741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362330PMC
December 2018

Bioactive compounds in plant materials for the prevention of diabetesand obesity.

Authors:
Eisuke Kato

Biosci Biotechnol Biochem 2019 Feb 17:1-11. Epub 2019 Feb 17.

a Division of Fundamental AgriScience and Research, Research Faculty of Agriculture , Hokkaido University , Kita-ku, Sapporo , Hokkaido , Japan.

Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. Read More

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http://dx.doi.org/10.1080/09168451.2019.1580560DOI Listing
February 2019

Expanding the genetic and clinical spectrum of the NONO-associated X-linked intellectual disability syndrome.

Am J Med Genet A 2019 Feb 17. Epub 2019 Feb 17.

Division of Medical Genetics, University of Utah, Salt Lake City, Utah.

The NONO gene encodes a nuclear protein involved in RNA metabolism. Hemizygous loss-of-function NONO variants have been associated with syndromic intellectual disability and with left ventricular noncompaction (LVNC). A two-year-old boy presented to the University of Utah's Penelope Undiagnosed Disease Program with developmental delay, nonfamilial features, relative macrocephaly, and dilated cardiomyopathy with LVNC and Ebstein anomaly. Read More

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http://dx.doi.org/10.1002/ajmg.a.61091DOI Listing
February 2019
1 Read

Homozygous variant in OTX2 and possible genetic modifiers identified in a patient with combined pituitary hormone deficiency, ocular involvement, myopathy, ataxia, and mitochondrial impairment.

Am J Med Genet A 2019 Feb 17. Epub 2019 Feb 17.

Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Here we report on a singleton patient affected by a complicated congenital syndrome characterized by growth delay, retinal dystrophy, sensorineural deafness, myopathy, ataxia, combined pituitary hormone deficiency, associated with mitochondrial impairment. Targeted clinical exome sequencing led to the identification of a homozygous missense variant in OTX2. Since only dominant mutations within OTX2 have been associated with cases of syndromic microphthalmia, retinal dystrophy with or without pituitary dysfunctions, this represents the first report of an OTX2 recessive mutation. Read More

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http://dx.doi.org/10.1002/ajmg.a.61092DOI Listing
February 2019

Epilepsy, depression, and growth hormone.

Epilepsy Behav 2019 Feb 14. Epub 2019 Feb 14.

Clinical and Translational Science Center, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, United States of America.

Depression affects a large proportion of patients with epilepsy, and is likely due in part to biological mechanism. Hormonal dysregulation due to the disruptive effects of seizures and interictal epileptiform discharges on the hypothalamic-pituitary-adrenal axis likely contributes to high rates of depression in epilepsy. This paper reviews the largely unexplored role of neuroendocrine factors in epilepsy-related depression, focusing on Growth Hormone (GH). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.022DOI Listing
February 2019

ACROSTART: A retrospective study of the time to achieve hormonal control with lanreotide Autogel treatment in Spanish patients with acromegaly.

Endocrinol Diabetes Nutr 2019 Feb 14. Epub 2019 Feb 14.

Endocrinology Department, Hospital General Universitario de Alicante-ISABIAL-FISABIO, Alicante, Spain.

Objectives: The ACROSTART study was intended to determine the time to achieve normalization of GH and IGF-I levels in responding patients with acromegaly administered different dosage regimens of lanreotide Autogel (Somatuline Autogel).

Methods: From March 2013 to October 2013, clinical data from 57 patients from 17 Spanish hospitals with active acromegaly treated with lanreotide for ≥4 months who achieved hormonal control (GH levels <2.5ng/ml and/or normalized IGF-I levels in ≥2 measurements) were analyzed. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.12.004DOI Listing
February 2019

Review: The role of zinc in the endocrine system.

Pak J Pharm Sci 2019 Jan;32(1):231-239

Selcuk University, Medical School, Department of Physiology, Konya, Turkey.

Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Read More

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January 2019
3 Reads

Auxological characteristics of pediatric patients with permanent or transient isolated growth hormone deficiency. Response to treatment and final height.

Endocrinol Diabetes Nutr 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Endocrinología y Diabetes Pediátrica, Servicio de Pediatría, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, España.

Introduction: Treatment with recombinant human growth hormone (rhGH) has been shown to improve adult height in pediatric patients with GH deficiency (GHD). However, reassessment of patients after they reach their final height shows some of them have permanent GH deficiency (PGHD), while others had a transient deficiency (TGHD). The study objective was to assess, in a cohort of pediatric patients with GHD, potential differences in response to treatment with rhGH depending on whether deficiency is permanent or transient. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.11.007DOI Listing
February 2019

Influence of Growth Factors on the Development of Necrotizing Enterocolitis.

Clin Perinatol 2019 Mar 20;46(1):51-64. Epub 2018 Dec 20.

Department of Pediatric Surgery, Nationwide Children's Hospital, FB6135, 700 Children's Drive, Columbus, OH 43205, USA. Electronic address:

Growth factors have important roles in gastrointestinal tract development, maintenance, and response to injury. Various experiments have been used to demonstrate growth factor influence in multiple disease processes. These studies demonstrated enhancement of mucosal proliferation, intestinal motility, immune modulation, and many other beneficial effects. Read More

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http://dx.doi.org/10.1016/j.clp.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380490PMC

Outcomes in different age groups with primary Ewing sarcoma of the spine: a systematic review of the literature.

J Neurosurg Spine 2019 Feb 15:1-10. Epub 2019 Feb 15.

4Division of Neurosurgery, University of Arizona, Tucson; and.

OBJECTIVEEwing sarcoma (ES) is among the most prevalent of bone sarcomas in young people. Less often, it presents as a primary lesion of the spine (5%-15% of patients with ES).METHODSA systematic literature search was performed, querying several scientific databases per PRISMA guidelines. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18795DOI Listing
February 2019
1 Read

Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring.

Aquat Toxicol 2019 Feb 7;209:132-141. Epub 2019 Feb 7.

Key Laboratory of Preparation and Application of Environmental Friendly Materials, the Ministry of Education, Jilin Normal University, Siping, 136000, China.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a re-emerging environmental contaminant used as a suitable substitute for brominated flame retardants. The objective of this study was to evaluate the effects of TDCIPP on thyroid disruption and growth inhibition in zebrafish (Danio rerio) offspring after chronic parental exposure, and to examine the possible molecular mechanisms involved. When adult zebrafish (4 months old) were exposed to 5. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.004DOI Listing
February 2019
2 Reads

Mathematical models applied to thyroid cancer.

Biophys Rev 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.

Thyroid cancer is the most prevalent endocrine neoplasia in the world. The use of mathematical models on the development of tumors has yielded numerous results in this field and modeling with differential equations is present in many papers on cancer. In order to know the use of mathematical models with differential equations or similar in the study of thyroid cancer, studies since 2006 to date was reviewed. Read More

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http://dx.doi.org/10.1007/s12551-019-00504-7DOI Listing
February 2019
1 Read

Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate-A perplexing perspective.

Authors:
Edwin D Lephart

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Physiology and Developmental Biology and The Neuroscience Center, College of Life Science, Brigham Young University, Provo, Utah.

Several journal reports, reviews, and commentaries over the last 20-25 years have pointed out the controversy attached to 17β-estradiol's inhibitory or stimulatory influence on hair follicle growth/cycling citing rodent (murine) and human results. While 17β-estradiol is the most potent sex steroid hormone in the body and has almost equal affinity for estrogen receptor (ER) alpha (α) and beta (β), there appears to be specific ER-mediated effects on scalp hair follicles/growth, etc. Additionally, the newly discovered G protein-coupled estrogen receptor (GPR30 or GPER) and the orphan receptor, estrogen-related receptor (ERR) gamma (γ), in skin and other tissue sites have potential impacts of how estrogens via these receptors may alter scalp hair characteristics, but this remains to be elucidated. Read More

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http://dx.doi.org/10.1111/jocd.12888DOI Listing
February 2019

Structure-based virtual screening for insect ecdysone receptor ligands using MM/PBSA.

Bioorg Med Chem 2019 Feb 5. Epub 2019 Feb 5.

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

The ecdysone receptor (EcR) is an insect nuclear receptor that is activated by the molting hormone, 20-hydroxyecdysone. Because synthetic EcR ligands disrupt the normal growth of insects, they are attractive candidates for new insecticides. In this study, the Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA) method was used to predict the binding activity of EcR ligands. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.02.011DOI Listing
February 2019

Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

The World Health Organization (WHO) defines glycogen-rich clear cell carcinoma (GRCC) of the breast as a carcinoma with glycogen accumulation in more than 90% of its tumor cells. Due to the rarity of this disease, its reported survival and clinical associations have been inconsistent due to reliance on case reports and limited case series. As a result, the prognostic implication of this cancer subtype remains unclear. Read More

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http://dx.doi.org/10.3390/jcm8020246DOI Listing
February 2019
1 Read

The Acute Inflammatory Response after Trauma is heightened by Frailty: A Prospective Evaluation of Inflammatory and Endocrine System Alterations in Frailty.

J Trauma Acute Care Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, University of Arizona, College of Medicine, Tucson, Arizona.

Introduction: Frailty is a geriatric syndrome characterized by decreased physiological reserves, increased inflammation, and decreased anabolic-endocrine response. The biomarkers associated with frailty are poorly understood in trauma. The aim of this study was to analyze the association between frailty and immune: IL-1β, IL-6, IL-2Rα, TNF-α and endocrine biomarkers: Insulin-like growth factor-1(IGF-1), and growth hormone(GH) in trauma patients. Read More

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http://dx.doi.org/10.1097/TA.0000000000002229DOI Listing
February 2019
2 Reads

The effect of JAK1/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Klinikum der Universität München, Munich, Germany.

Numerous cytokines have been implicated in the pathogenesis of inflammatory diseases, and their dysregulation is a main feature of rheumatoid arthritis (RA). Cytokines stimulate signal transduction through several intracellular pathways, including Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways, leading to changes in cell activation, proliferation and survival. Consequently, agents that selectively target elements of the JAK/STAT pathways have received significant attention in recent years as potential new treatments for the disease. Read More

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February 2019
1 Read

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment.

Cancer Biol Med 2018 Nov;15(4):443-451

Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy. This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372914PMC
November 2018
1 Read

Endocrine responses following exhaustive strength exercise with and without the use of protein and protein-carbohydrate supplements.

Biol Sport 2018 Dec 13;35(4):399-405. Epub 2018 Nov 13.

Department of Sports Theory, Academy of Physical Education in Katowice, Poland.

The aim of this study was to determine the effect of carbohydrate-protein supplementation with whey protein (CHO-PROw) after resistance training, and casein protein (PROc) before bedtime on the concentration of growth hormone (GH), insulin (I) and insulin-like growth factor (IGF-1), as well as serum creatine kinase (CK) activity. Twelve strength trained male subjects (age: 25.8 ± 4. Read More

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http://dx.doi.org/10.5114/biolsport.2018.75754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358528PMC
December 2018

Dopamine agonist-responsive Cushing's disease.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Endocrinology, University Hospital Zürich, Zürich, Switzerland.

A 47-year-old Caucasian man was referred to our clinic with a severe clinical and biochemical phenotype of endogenous hypercortisolism for further evaluation and treatment. In addition to confirming adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome, we found left temporal hemianopsia, massively increased prolactin, increased growth hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. As the cause of these abnormalities we revealed an invasive macroadenoma of the pituitary secreting ACTH, prolactin and growth hormone, resulting not only in a clinically predominant picture of Cushing's syndrome but also causing hypogonadotropic hypogonadism and central hypothyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2018-228045DOI Listing
February 2019
6 Reads

Bilateral osteonecrosis of the hip in panhypopituitarism.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Osteonecrosis, also known as avascular necrosis, is a condition that causes significant morbidity and loss of function. It is a common complication seen with supraphysiological steroid use. Early diagnosis is critical as it impacts prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227471DOI Listing
February 2019
9 Reads

Cartilage-Targeted IGF-1 Treatment to Promote Longitudinal Bone Growth.

Mol Ther 2019 Feb 1. Epub 2019 Feb 1.

Section on Growth and Development, National Institute of Child Health and Development, NIH, Bethesda, MD 20892, USA.

Recombinant human growth hormone (GH) is commonly used to treat short stature in children. However, GH treatment has limited efficacy, particularly in severe, non-GH-deficient conditions such as chondrodysplasias, and potential off-target effects. Because short stature results from decreased growth plate chondrogenesis, we developed a cartilage-targeting single-chain human antibody fragment (CaAb) aiming to deliver therapeutic molecules to the growth plate, thereby increasing treatment efficacy while minimizing adverse effects on other tissues. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.01.017DOI Listing
February 2019
1 Read
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