2,265,082 results match your criteria Growth Hormone & IGF Research [Journal]


Investigations on the prevalence of tortoise picorna-virus in captive tortoises in Germany.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):304-308. Epub 2018 Dec 12.

Objective: Tortoise picornavirus (ToPV) has been speculated to play an important role in the frequently seen disease pattern of juvenile shell softening. This study aimed to determine ToPV prevalence among German tortoise collections.

Material And Methods: A total of 334 animals selected from 27 different collections were included. Read More

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October 2018
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Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

RNA Biology Group, Institute for Molecular Infection Biology, University of Würzburg, D-97080 Würzburg, Germany.

Global RNA profiling studies in bacteria have predicted the existence of many of small noncoding RNAs (sRNAs) that are processed off mRNA 3' ends to regulate other mRNAs via the RNA chaperones Hfq and ProQ. Here, we present targets of SdhX (RybD), an Hfq-dependent sRNA that is generated by RNase E mediated 3' processing of the ∼10 000-nt mRNA of the TCA cycle operon sdhCDAB-sucABCD in enteric bacteria. An in silico search predicted ackA mRNA, which encodes acetate kinase, as a conserved primary target of SdhX. Read More

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December 2018

Oocyte-Secreted Factors Synergize with FSH to Promote Aromatase Expression in Primary Human Cumulus Cells.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology and Biophysics, University of Illinois at Chicago.

Context: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.

Objective: Determine GDF9 and BMP15 effects on follicle-stimulating hormone (FSH) stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression. Read More

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December 2018

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor regulates Hepatic Lipogenesis under healthy Diet.

J Clin Endocrinol Metab 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Germany.

Context: The effect of a lifestyle intervention to reduce liver fat content in nonalcoholic fatty liver disease in humans is influenced by genetics. We hypothesized that the functionally active amino acid exchange in humans Gly388Arg (mouse homologue: Gly385Arg) in the fibroblast growth factor receptor 4 (FGFR4), which regulates bile acid, lipid and glucose metabolism, may determine the dynamics of hepatic lipid accumulation and insulin sensitivity in humans. Mechanisms of this substitution were studied in mice under normal chow and high-fat diet. Read More

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December 2018
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Expression of GHR and downstream signaling genes in human adipose tissue - relation to obesity and weight-change.

J Clin Endocrinol Metab 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Context: Growth hormone (GH) is a strong regulator of metabolism. In obesity, both GH secretion and adipose tissue GHR gene expression are decreased. More detailed information on the regulation of GHR, STAT3/5 and downstream-regulated genes in human adipose tissue during diet-induced weight loss and weight gain is lacking. Read More

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December 2018

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. Read More

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December 2018

Functionally distinct assembly of vascular plants colonizing alpine cushions suggests their vulnerability to climate change.

Ann Bot 2018 Dec 12. Epub 2018 Dec 12.

Institute of Botany, The Czech Academy of Sciences, Průhonice, Czech Republic.

Background And Aims: Alpine cushion plants can initially facilitate other species during ecological succession, but later on can be negatively affected by their development, especially when beneficiaries possess traits allowing them to overrun their host. This can be reinforced by accelerated warming favouring competitively strong species over cold-adapted cushion specialists. However, little empirical research has addressed the trait-based mechanisms of these interactions. Read More

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December 2018
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Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

TNM classification of malignant tumors (Breast Cancer Study Group).

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

The eighth editions of the primary tumor, lymph node and metastasis classifications for breast cancer issued by the American Joint Commission of Cancer and the Union for International Cancer Control were revised in 2017. The major change made by the American Joint Commission of Cancer is to incorporate biological factors such as estrogen and progesterone receptor, human epidermal growth factor receptor 2, histological grade and multigene prognostic assays, into the staging system. Tumor biomarkers and low recurrence scores confirmed by multigene prognostic assays change the staging. Read More

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December 2018

Management of paediatric patients with medically-refractory Crohn's disease using Ustekinumab: A multi-centred cohort study.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, Montreal Children's Hospital, Department of Paediatrics, McGill University, Montreal, Quebec, Canada.

Background: Ustekinumab (UST) is effective in the treatment of adults with moderate to severe Crohn's disease (CD). There is a paucity of data on its use in children.

Aim: To evaluate the response to UST in children with moderate to severe CD. Read More

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December 2018
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IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis.

Cell Rep 2018 Dec;25(11):3021-3035.e5

Department of Hematology, Cancer Center Amsterdam (CCA), Amsterdam UMC, VU Medical Center, Amsterdam, the Netherlands. Electronic address:

Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic stem cells (HSCs), we performed gene expression profiling of LSCs, HSCs, and leukemic progenitors all residing within the same AML bone marrow and identified insulin-like growth factor-binding protein 7 (IGFBP7) as differentially expressed. Low IGFBP7 is a feature of LSCs and is associated with reduced chemotherapy sensitivity. Read More

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December 2018
2 Reads

Phosphatidyl Inositol 3-Kinase (PI3K)-mTOR Inhibitor PKI-402 Inhibits Breast Cancer Induced Osteolysis.

Cancer Lett 2018 Dec 9. Epub 2018 Dec 9.

Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China, 515041. Electronic address:

Bone metastasis causes bone pain and pathological bone fracture in breast cancer patients with a serious complication. Previous studies have demonstrated that a novel phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 suppressed the growth of breast cancer cells. However, the role of PKI-402 involved in osteolysis induced by breast cancer remains unclear. Read More

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December 2018

The Tyrosine Kinase Inhibitor TAS-115 Attenuates Bleomycin-Induced Lung Fibrosis in Mice.

Am J Respir Cell Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

University of Tokushima Graduate School, Respiratory Medicine and Rheumatology, Tokushima, Japan ;

The signaling pathways of growth factors including platelet-derived growth factor (PDGF) can be considered specific targets for overcoming the poor prognosis of idiopathic pulmonary fibrosis (IPF). Nintedanib, the recently approved multiple kinase inhibitor, has shown promising anti-fibrotic effects in IPF patients; however, its efficacy is still limited, and in some cases, treatment discontinuation is necessary due to toxicities such as gastrointestinal disorders. Therefore, more effective agents with less toxicity are still needed. Read More

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December 2018

Structure-activity relationships of the bacteriocin bactofencin A and its interaction with bacterial membrane.

ACS Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

The antimicrobial peptide bactofencin A is an unmodified non-pediocin-like bacteriocin that inhibits several clinically relevant pathogens including Listeria monocytogenes and Staphylococcus aureus. Here we report the synthesis and structure-activity relationship studies of bactofencin A and novel analogs thereof. Synthetic bactofencin A was a potent inhibitor of L. Read More

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December 2018

Differential gene expression between the vigorous and dwarf litchi cultivars based on RNA-Seq transcriptome analysis.

PLoS One 2018 12;13(12):e0208771. Epub 2018 Dec 12.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China) in Ministry of Agriculture, College of Horticulture, South China Agricultural University, Guangzhou, China.

Litchi (Litchi chinesis Sonn.) is the most economically significant member of Sapindaceae family, especially in sub-tropical regions. However, its tall tree body often brings many inconveniences to production management. Read More

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December 2018

Partitioning the efficiency of utilization of amino acids in growing broilers: Multiple linear regression and multivariate approaches.

PLoS One 2018 12;13(12):e0208488. Epub 2018 Dec 12.

Department of Animal Science, University of California, Davis, California, United States of America.

Determining the efficiency of amino acid (AA) utilization in growing animals is crucial to estimate their requirement accurately. In broiler chickens, the composition of AA in feather is different from feather-free body and the proportion of feathers will change along broiler's growth, which may impact the efficiency of utilization on AA consumed. Therefore, in order to establish a method that predicts the efficiency of utilization for feather-free body and feather, two approaches were evaluated: a multiple linear regression and a multivariate analysis. Read More

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December 2018
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Quality and quantity of leaf litter: Both are important for feeding preferences and growth of an aquatic shredder.

PLoS One 2018 12;13(12):e0208272. Epub 2018 Dec 12.

Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.

The study of leaf litter as a resource for shredders has emerged as a key topic in trophic links in ecology. However, thus far, most studies have emphasized the leaf quality as one of the main determinants of shredder behaviour and growth without simultaneously considering the leaf quantity availability. Nevertheless, the combined effects of leaf quantity and quality on shredder behaviour and growth is particularly crucial to further understand how ecosystem functioning may respond to the increasing flow intermittency due to climate change. Read More

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December 2018

Desert plant bacteria reveal host influence and beneficial plant growth properties.

PLoS One 2018 12;13(12):e0208223. Epub 2018 Dec 12.

Desert Agriculture Initiative, King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences and Engineering Division (BESE), Thuwal, Kingdom of Saudi Arabia.

Deserts, such as those found in Saudi Arabia, are one of the most hostile places for plant growth. However, desert plants are able to impact their surrounding microbial community and select beneficial microbes that promote their growth under these extreme conditions. In this study, we examined the soil, rhizosphere and endosphere bacterial communities of four native desert plants Tribulus terrestris, Zygophyllum simplex, Panicum turgidum and Euphorbia granulata from the Southwest (Jizan region), two of which were also found in the Midwest (Al Wahbah area) of Saudi Arabia. Read More

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December 2018
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Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS.

PLoS One 2018 12;13(12):e0207161. Epub 2018 Dec 12.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.

The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metabolite- responsive regulators and two-component systems. S. aureus has a two-component system encoded by the gene pair sav0224 (hptS) and sav0223 (hptR) that regulate the hexose phosphate transport (uhpT) system in response to extracellular glucose-6-phosphate. Read More

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December 2018

Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.

PLoS Genet 2018 Dec 12;14(12):e1007821. Epub 2018 Dec 12.

Cancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies. Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks. Zebrafish harbor homologs for nearly all known FA genes. Read More

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December 2018
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Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

PLoS One 2018 12;13(12):e0207140. Epub 2018 Dec 12.

R&D Alternative Discovery and Development, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestinal crypt cell regeneration. Motivated by the observations that the upregulation of Atoh1 gene expression, through genetic manipulation or pharmacological inhibition of Notch signaling (e.g. Read More

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December 2018

Vertebral Growth Around Distal Instrumented Vertebra in Patients With Early-Onset Scoliosis who Underwent Traditional Dual Growing Rod Treatment.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Study Design: Retrospective radiographic study.

Objective: To investigate the growth of the vertebrae around distal instrumented vertebra (DIV) in patients with early-onset scoliosis (EOS) who underwent dual growing rod (DGR) treatment.

Summary Of Background Data: Previous studies indicated that DGR was likely to preserve or even stimulate the spinal growth. Read More

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December 2018
2 Reads

The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Pediatric Gastroenterology, Hepatology and Nutrition, Atatürk University, Erzurum, Turkey.

Objectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study.

Methods: Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. Read More

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December 2018
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Differential Gene Expression in Erlotinib-treated Fibroblasts.

Nurs Res 2018 Dec 12. Epub 2018 Dec 12.

Assistant Professor, University of South Carolina, College of Nursing, Columbia, SC Bioinformatics Analyst I, University of Maryland, Baltimore, School of Medicine, Institute for Genome Sciences, Baltimore, MD Professor, Chair, Department of Hematology/Oncology, Deputy Director of the Cancer Center for Clinical Research, G. Morris Dorrance Chair in Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA Bioinformatics Analyst II, University of Maryland, School of Medicine, Institute for Genome Sciences, Baltimore, MD Laboratory Research Technician, University of Maryland, Baltimore, School of Nursing, Baltimore, MD Professor, Chair, Department of Pain and Translational Symptom Science, University of Maryland, Baltimore, School of Nursing, Baltimore, MD.

Background: Therapies targeting the epidermal growth factor receptor (EGFR) result in a painful rash, the most common and debilitating toxicity among patients with non-small cell lung cancer (NSCLC) who take EGFR tyrosine kinase inhibitor (TKI) therapy; however, predicting the development and the severity of the rash is difficult.

Objective: To examine how erlotinib-an EGFR TKI that NSCLC patients take to stop or slow tumor growth-altered the transcriptome of dermal fibroblasts.

Methods: Dermal fibroblasts (ATCC® PCS-201-012™) were seeded in cell culture flasks, grown under standard conditions, and transferred to cell culture dishes. Read More

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December 2018

Efficacy of Minimally Invasive Intervention in Patients with Acute Cerebral Infarction.

J Cardiovasc Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan City, Shanxi Province, China.

Our aim was to explore the efficacy of minimally invasive intervention in patients with acute cerebral infarction (ACI). Seventy patients with ACI were randomized into either an experimental group or a control group. In addition to the regular treatment, patients in the control group also received intravenous thrombolysis with urokinase, while patients in the other group underwent percutaneous transluminal cerebral angioplasty and stenting. Read More

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December 2018

IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis.

Pancreas 2019 Jan;48(1):94-98

From the Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: IQ motif containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for aberrant mitogen-activated protein kinase (MAPK) signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC.

Methods: We inhibited IQGAP1 expression using shRNA and assessed clonogenic growth, cell migration, and MAPK signaling in vitro and tumor initiation and metastasis in vivo. Read More

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January 2019

Systematic review addressing nurse practitioner reimbursement policy: Part one of a four-part series on critical topics identified by the 2015 nurse practitioner research agenda.

J Am Assoc Nurse Pract 2018 Dec;30(12):673-682

PediatriCare of Northern Virginia, Haymarket, Virginia George Mason University/Mason and Partners Clinics, Fairfax, Virginia.

Background And Purpose: The growth and sustainability of nurse practitioners (NPs) requires transparent, fair and equitable reimbursement policies. Complicating this issue is variation in reimbursement policy within and across federal, state, and other payers. Even with explicit regulations, there remain questions on how reimbursement policies are covertly operationalized in practice. Read More

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December 2018

Correlation Between IL-20 and De Quervain's Disease Severity.

Ann Plast Surg 2019 Jan;82(1S Suppl 1):S6-S12

Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

De Quervain's disease is a stenosing tenosynovitis of the first dorsal compartment of the wrist. Histopathological studies have reported that the thickening of the first dorsal retinaculum is characterized by degeneration rather than inflammation. However, significant infiltration of mast cells and macrophages was noted in a torn tendon study, which suggested that innate immune pathways are part of the mechanism that mediates early tendinopathy. Read More

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January 2019

Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications.

Authors:
Kelly E McCann

Curr Opin Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Poly-ADP-ribosyl-polymerase (PARP) inhibitors are an increasingly-utilized therapy in women with high-grade serous ovarian carcinoma, but tumor resistance to PARP inhibitor monotherapy is inevitable.

Recent Findings: PARP inhibitors have been most studied in patients with breast and ovarian cancers associated with deleterious germline BRCA1 or BRCA2 mutations, though their role has expanded to include use as maintenance therapy in women with platinum-sensitive high-grade serous ovarian cancer due to the high propensity of such cancers to have defects in DNA repair by homologous recombination. As mechanisms of PARP inhibitor resistance are elucidated, rationale combination strategies can be devised to extend therapeutic benefits and to abrogate resistance. Read More

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December 2018
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Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, First Hospital of Shanxi Medical University, Taiyua, Shanxi 030001, China.

Anaplastic thyroid carcinoma (ATC) responds for the majority of death of thyroid carcinoma and often causes chemotherapy resistance. We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR-144-3p and Transforming Growth Factor α (TGF-α). Differentially expressed circRNAs in PTC were analyzed using the GSE93522 data downloaded. Read More

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December 2018

The Dual Effect of the Brassinosteroid Pathway on Rice Black Streaked Dwarf Virus Infection by Modulating the Peroxidase-Mediated Oxidative Burst and Plant Defense.

Mol Plant Microbe Interact 2018 Dec 12. Epub 2018 Dec 12.

Fenghua Road 818,Ningbo, China , 315211 ;

The phytohormone brassinosteroids (BR) not only played key roles in regulating plant growth development but also involved in modulating plant defense system upon pathogens attack. Our previous study found that BR pathway was susceptible to Rice Blacked-Streaked Dwarf Virus (RBSDV), a devastating pathogen in rice. However, the detailed mechanism of BR-mediated susceptibility remains unclear. Read More

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December 2018

The RSc0454 encoded FAD-linked oxidase is indispensable for pathogenicity in Ralstonia solanacearum GMI1000.

Mol Plant Microbe Interact 2018 Dec 12. Epub 2018 Dec 12.

Fujian Agriculture and Forestry University, College of Plant Protection , 15 Shangxiadian Road , Fuzhou, China , 350002 ;

Ralstonia solanacearum is the causal agent of bacterial wilt disease. Here, we report that a large FAD-linked oxidase encoded by RSc0454 in GMI1000 is required for pathogenicity, which is composed of 1345 amino acids, including a DUF3683, a lactate dehydrogenase (LDH), and a succinate dehydrogenase (SDH) domain. The RSc0454 protein showed both LDH and SDH activities. Read More

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December 2018

Contribution of KUPs to potassium and cesium accumulation appears complementary in Arabidopsis.

Plant Signal Behav 2018 Dec 12:1-3. Epub 2018 Dec 12.

a RIKEN Center for Sustainable Resource Science , Yokohama , Japan.

Cesium has no known beneficial effects on plants and while plants have the ability to absorb it through the root system, plant growth is retarded at high concentrations. Recently, we have shown that potassium influx through a potassium channel complex AKT1-KC1 is inhibited by cesium in Arabidopsis thaliana and the resultant reduction in potassium accumulation in the plant is the primary cause of retarded growth. By contrast, a major potassium transporter, HAK5 whose function is crucial under potassium deficiency, was found to be either not affected or complementary under cesium stress in the low affinity potassium range. Read More

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December 2018
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Sheet-like and tubular aggregates of protein nanofibril-phosphate hybrids.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

CAS Key Lab of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China. and Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 9A Yuquan Road, Beijing 100049, China.

Bovine serum albumin assembled into supramolecular fibrils and aligned into microtubes and nanosheets upon simply heating and cooling its solution in phosphate buffer under carefully-selected conditions. This unique "one-batch" synthesis was justified by the one-dimensional growth of phosphate crystals in combination with the strong affinity of phosphate ions to protein fibrils. Read More

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December 2018

Stature, Body Mass, and Body Mass Index in High School American Football Players: Appropriate Determinants of Obesity Prevalence?

J Strength Cond Res 2018 Nov;32(11):3119-3126

Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE.

Mendez, AI, Miramonti, AA, Gillen, ZM, McKay, BD, Leutzinger, TJ, and Cramer, JT. Stature, body mass, and BMI in high school american football players: Appropriate determinants of obesity prevalence? J Strength Cond Res 32(11): 3119-3126, 2018-The purpose of this study was to evaluate stature (HT), mass (BM), body mass index (BMI), and obesity prevalence based on BMI categories in a large sample (n = 7,175) of high school American football players enrolled as freshmen, sophomores, or juniors. Players were categorized by their positions: offensive linemen (OLs), defensive linemen (DLs), tight end, defensive end, linebacker, running back, quarterback, defensive back, and wide receiver. Read More

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November 2018

Interaction between typical sulfonamides and bacterial diversity in drinking water.

J Water Health 2018 Dec;16(6):914-920

School of Environmental Science and Engineering, Tianjin University, Tianjin, China E-mail:

The abuse of antibiotics is becoming more serious as antibiotic use has increased. The sulfa antibiotics, sulfamerazine (SM1) and sulfamethoxazole (SMZ), are frequently detected in a wide range of environments. The interaction between SM1/SMZ and bacterial diversity in drinking water was investigated in this study. Read More

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December 2018

Lysobacter tabacisoli sp. nov., isolated from rhizosphere soil of Nicotiana tabacum L.

Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.

1​State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China.

A Gram-stain-negative, aerobic, rod-shaped bacterium, designated strain C8-1, was isolated from the rhizosphere soil of Nicotiana tabacum L. collected from Kunming, south-west China. The cells showed oxidase-positive and catalase-positive reactions. Read More

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December 2018
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Thiosocius teredinicola gen. nov., sp. nov., a sulfur-oxidizing chemolithoautotrophic endosymbiont cultivated from the gills of the giant shipworm, Kuphus polythalamius.

Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.

2​Department of Marine and Environmental Science, Ocean Genome Legacy Center, Northeastern University, Nahant MA 01908, USA.

A chemolithoautotrophic sulfur-oxidizing, diazotrophic, facultatively heterotrophic, endosymbiotic bacterium, designated as strain 2141T, was isolated from the gills of the giant shipworm Kuphus polythalamius (Teredinidae: Bivalvia). Based on its 16S rRNA sequence, the endosymbiont falls within a clade that includes the as-yet-uncultivated thioautotrophic symbionts of a marine ciliate and hydrothermal vent gastropods, uncultivated marine sediment bacteria, and a free-living sulfur-oxidizing bacterium ODIII6, all of which belong to the Gammaproteobacteria. The endosymbiont is Gram-negative, rod-shaped and has a single polar flagellum when grown in culture. Read More

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December 2018

Regulation of Ribosome Biogenesis in Skeletal Muscle Hypertrophy.

Physiology (Bethesda) 2019 Jan;34(1):30-42

The Center for Muscle Biology, College of Health Sciences, University of Kentucky , Lexington, Kentucky.

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis. The rates of protein synthesis are primarily dependent on translational efficiency and capacity. Ribosome biogenesis has emerged as an important regulator of skeletal muscle growth and maintenance by altering the translational capacity of the cell. Read More

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January 2019

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

Motion sickness as metaphor: engaging with diversity in STEM.

Adv Physiol Educ 2019 Mar;43(1):1-6

Department of Biology, Beloit College , Beloit, Wisconsin.

Science, technology, engineering, and math (STEM) continue to work to increase the diversity of the fields, yet there are still significant historical and societal hurdles to be overcome before we reach full representation throughout STEM. The concept of science identity has become a point of interest in this process; it has been suggested that development of one's identity as a scientist is critical to persistence in the field. Metaphors that are rooted in bodily experience can provide a starting point to understand abstract concepts, including science identity and how we as STEM educators respond to increasing diversity within our fields. Read More

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Development and evaluation of a combined bioenergetics and organic chemical mass-balance bioaccumulation model for fish.

Environ Sci Technol 2018 Dec 12. Epub 2018 Dec 12.

This study describes the development and evaluation of a new bioenergetically-balanced bioaccumulation (3B) model for organic chemicals in fish. The 3B model is developed from a large database of routine metabolic (oxygen consumption) rates comprising a range of species, body mass and temperature. The chemical uptake and elimination rates of the 3B model are compared against those from three existing bioaccumulation models. Read More

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December 2018

A Multi-functional Vector for delivery of Genome Editing Plasmid Targeting β-Catenin to Re-modulate Cancer Cell Properties.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

Accurate and efficient delivery of genome editing plasmids to targeted cells is of critical importance in genome editing. Herein, we prepared a multifunctional delivery vector with combination of ligand-mediated selectivity and peptide mediated transmembrane function to effectively deliver plasmids to targeted cancerous cells. In the delivery system, the CRISPR-Cas9 plasmid is combined with protamine with membrane and nuclear translocating activities and co-precipitated with CaCO3, which is further decorated by AS1411 functionalized carboxymethyl chitosan (ACMC) and TAT peptide functionalized carboxymethyl chitosan (TCMC). Read More

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December 2018

Trends in Postacute Care Spending Growth During the Medicare Spending Slowdown.

Issue Brief (Commonw Fund) 2018 Dec 1;2018:1-11. Epub 2018 Dec 1.

Department of Health Policy,t Vanderbilt University School of Medicine.

Issue: Over the past decade, traditional Medicare’s per-beneficiary spending grew at historically low levels. To understand this phenomenon, it is important to examine trends in postacute care, which experienced exceptionally high spending growth in prior decades.

Goal: Describe per-beneficiary spending trends between 2007 and 2015 for postacute care services among traditional Medicare beneficiaries age 65 and older. Read More

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December 2018

SOCIOECONOMIC AND NUTRITIONAL CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH SICKLE CELL ANEMIA: A SYSTEMATIC REVIEW.

Rev Paul Pediatr 2018 Oct-Dec;36(4):491-499

Departamento de Pediatria, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To describe the socioeconomic and nutritional characteristics of children and adolescents with sickle cell anemia.

Data Sources: The present study is a systematic literature review based on published scientific articles. The searches were carried out using the electronic database of the National Library of Medicine, National Institutes of Health- PubMed. Read More

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Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis.

J Appl Oral Sci 2018 Dec 10;27:e20180015. Epub 2018 Dec 10.

Gazi University, Faculty of Dentistry, Department of Oral Pathology, Ankara, Turkey.

Objectives: In this study, the effects of ozonetherapy on secondary wound healing were evaluated histologically and immuno-histochemically.

Material And Methods: Material and Methods: 8 healthy pigs were used in this study. Six wounds with 10 mm in diameter were created through the punch technique on the palatinal gingiva of each pig. Read More

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December 2018

Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum.

Mem Inst Oswaldo Cruz 2018 Dec 6;113(12):e180279. Epub 2018 Dec 6.

Fundação Oswaldo Cruz-Fiocruz, Instituto René Rachou, Laboratório de Malária Experimental e Humana, Belo Horizonte, MG, Brasil.

BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against human malaria. Drug repositioning is a fast and less expensive strategy for antimalarial drug discovery, because these compounds are already approved for human use. Read More

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December 2018

Factors associated with interpersonal violence among children from public schools in Fortaleza, Ceará, Brazil.

Cien Saude Colet 2018 Dec;23(12):4299-4309

Programa de Pós-Graduação em Saúde Coletiva, Universidade de Fortaleza. Fortaleza CE Brasil.

The school has witnessed the growth of manifestations of interpersonal violence among children, and in this perspective, this paper examines the prevalence of interpersonal violence in the relationship between students and the associated factors. This is a cross-sectional study developed with 874 public school students aged 10 and 11 years conducted in 2013. A questionnaire implemented the collection of data that were submitted to bivariate analysis with statistical significance calculation between associations. Read More

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December 2018

Evidence on nutritional assessment techniques and parameters used to determine the nutritional status of children and adolescents: systematic review.

Cien Saude Colet 2018 Dec;23(12):4209-4219

Programa de Pós-Graduação em Pediatria e Saúde da Criança, Pontifícia Universidade Católica do Rio Grande do Sul. Av. Ipiranga 6690/2º, Partenon. 90610-000 Porto Alegre RS Brasil.

This article aims to review systematically the evidence on nutritional assessment techniques and parameters used to determine the nutritional status of children and adolescents. The literature review and the selection of publications were performed using the Medline, Lilacs, SciELO, Embase, personal files. 17 studies were identified, 7 addressed the anthropometric indices as the main outcome, 7 analyzed the growth and development of children and adolescents through growth curves, and the remainder surveyed body composition. Read More

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December 2018
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