Search our Database of Scientific Publications and Authors

I’m looking for a

    20372 results match your criteria Graves Disease

    1 OF 408

    Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.
    Thyroid Res 2018 13;11. Epub 2018 Feb 13.
    Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University of Bialystok, ul. Waszyngtona 17, 15-274 Białystok, Poland.
    Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. Read More

    Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report.
    J Med Case Rep 2018 Feb 16;12(1):38. Epub 2018 Feb 16.
    Departamento de Endocrinología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
    Background: Exophthalmos, myxedema, and osteoarthropathy syndrome is a very rare condition that is associated with Graves' disease. The presence of dermopathy and the involvement of joint/bone tissues indicate that it seems to be related with the severity of the autoimmune process. Owing to its low incidence, there is a lack of information regarding its treatment and clinical follow-up. Read More

    Graves' disease coexisting with resistance to thyroid hormone: a rare case.
    Clin Case Rep 2018 Feb 29;6(2):337-341. Epub 2017 Dec 29.
    Endocrine and Diabetes CenterAffiliated Hospital of Integrated Traditional Chinese and Western MedicineJiangsu Province Academy of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina.
    A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland. Read More

    Body weight change is unpredictable after total thyroidectomy.
    ANZ J Surg 2018 Feb 14. Epub 2018 Feb 14.
    Monash University Endocrine Surgery Unit, The Alfred Hospital, Melbourne, Victoria, Australia.
    Background: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery.

    Methods: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014. Read More

    Association ofpromoter polymorphism and Graves' disease: an updated systematic review and meta-analysis.
    Biosci Rep 2018 Feb 13. Epub 2018 Feb 13.
    Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Graves' disease (GD) is a common autoimmune disorder with a genetic predisposition. Owing to the biological effect ofon the thyroid gland and its gene location,should be able to influence an individual's susceptibility to GD. In this study, we conduct a meta-analysis of rs1800629 and rs361525 ingene from all eligible case-control studies to assess the associations among reportedgene with GD. Read More

    Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves' disease.
    Auto Immun Highlights 2018 Feb 12;9(1). Epub 2018 Feb 12.
    Clinical Pathology Laboratory, S. Maria degli Angeli Hospital, Pordenone, Italy.
    Purpose: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs.

    Methods: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiAanti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAKRIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the ImmuliteTSI assay (Siemens Healthcare, Llanberis, UK). Read More

    The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells.
    Crit Rev Immunol 2017 ;37(1):1-13
    Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Forkhead box-O (FOXO) transcription factors have a fundamental role in the development and differentiation of immune cells. FOXO1 and FOXO3 are FOXO members that are structurally similar and bind to the same conserved consensus DNA sequences to induce transcription. FOXO1 has been studied in detail in the activation of dendritic cells (DCs), where it plays an important role through the regulation of target genes such as ICAM-1, CCR7, and the integrin αvβ3. Read More

    Correction to: Does Surgery Without Lugol's Solution Pretreatment for Graves' Disease Increase Surgical Morbidity?
    World J Surg 2018 Feb 8. Epub 2018 Feb 8.
    The Department of Digestive and Endocrine Surgery, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, 165 Chemin du Grand Revoyet, 69495, Pierre Bénite, France.
    In the original article, Mathieu Bonal's last name was spelled incorrectly. It is correct as reflected here. The original article has also been updated. Read More

    Epidemiology and Clinical Features of Thyroid-associated Orbitopathy in Accra.
    Middle East Afr J Ophthalmol 2017 Oct-Dec;24(4):183-189
    Department of Surgery, Eye Unit, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
    Purpose: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. Read More

    Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.
    Arch Endocrinol Metab 2017 Dec;61(6):600-607
    Endocrinología, Hospital do Servidor Público Estadual (IAMSPE), São Paulo, SP Brasil.
    Objective: Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C).

    Subjects And Methods: We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4. Read More

    The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults.
    Mult Scler Relat Disord 2018 Jan 14;19:161-165. Epub 2017 Oct 14.
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; School of Medicine, University of Tasmania, Hobart, Australia. Electronic address:
    Background: While common variant non-HLA (human leukocyte antigen) alleles have been associated with MS risk, their role in disease course is less clear. We sought to determine whether established multiple sclerosis (MS) genetic susceptibility factors are associated with relapse rate in children and an independent cohort of adults with MS.

    Methods: Genotyping was performed for 182 children with MS or clinically isolated syndrome with high risk for MS from two Pediatric MS Centers. Read More

    Orbital radiotherapy plus three-wall orbital decompression in a patient with rare ocular manifestations of thyroid eye disease: case report.
    BMC Endocr Disord 2018 Feb 6;18(1). Epub 2018 Feb 6.
    Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 ZhiZaoJu Road, Shanghai, 200011, China.
    Background: Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss.

    Case Presentation: A 74-year-old man experienced active TED with extremely severe redness and swelling of the conjunctiva, loss of visual acuity and exacerbation of disfiguring proptosis. Read More

    PTPN22 and CTLA-4 Polymorphisms are Associated with Polyglandular Autoimmunity.
    J Clin Endocrinol Metab 2018 Feb 1. Epub 2018 Feb 1.
    Molecular Thyroid Research Laboratory (JH, CD, LF, GJK), Johannes Gutenberg University Medical Center, Mainz, Germany.
    Context: Single nucleotide polymorphisms (SNP) of various genes increase susceptibility to monoglandular autoimmunity. Scarce data are available in autoimmune polyglandular syndromes (APS).

    Objective: Evaluate potential associations of eight SNP with APS. Read More

    Thyroid Autoimmunity: An Interplay of Factors.
    Vitam Horm 2018 4;106:129-145. Epub 2017 Sep 4.
    Virginia Commonwealth University, Richmond, VA, United States.
    The literature on thyroid autoimmunity has identified many potential factors at play for the initiation and progression of autoimmune thyroid diseases. These factors include genetic susceptibility, environmental factors, some drugs, iodine and selenium, infection, molecular mimics, and immune system defects. The sheer number of feasible factors makes sorting out the necessary agents from the fellow travelers difficult. Read More

    Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases.
    J Altern Complement Med 2018 Feb 6. Epub 2018 Feb 6.
    1 Department of Endocrinology, Traditional Chinese Medicine Hospital of Shanxi , Xi'an, China .
    Purpose: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines.

    Methods: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone. Read More

    Neonatal Thyrotoxicosis.
    Clin Perinatol 2018 Mar 16;45(1):31-40. Epub 2017 Dec 16.
    Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, The Thyroid Center, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:
    Neonatal thyrotoxicosis (hyperthyroidism) is less prevalent than congenital hypothyroidism; however, it can lead to significant morbidity and mortality if not promptly recognized and adequately treated. Most cases are transient, secondary to maternal autoimmune hyperthyroidism (Graves disease [GD]). This article summarizes recommendations for screening and management of hyperthyroidism in both the fetal and neonatal periods, with a focus on neonatal thyrotoxicosis secondary to maternal GD. Read More

    Associations of TNFRSF1A Polymorphisms with Autoimmune Thyroid Diseases: A Case-Control Study.
    Horm Metab Res 2018 Feb 5;50(2):117-123. Epub 2018 Feb 5.
    Department of Endocrinology, Jinshan Hospital of Fudan University, Jinshan District, Shanghai, China.
    Previous studies have shown associations of polymorphisms in the tumor necrosis factor (TNF) receptor super family member 1A () gene with several groups of inflammatory and autoimmune related diseases, but associations ofpolymorphisms with autoimmune thyroid diseases (AITD), mainly including two sub-types of Hashimoto's thyroiditis (HT) and Graves' disease (GD), in the Chinese Han population is unclear. A case-control study of 1812 subjects (965 AITD patients and 847 unrelated healthy controls) was conducted to assess AITD associations with five single nucleotide polymorphisms (SNPs), including rs4149576, rs4149577, rs4149570, rs1800693, and rs767455 in thegene locus. Genotyping was performed and evaluated using the platform of ligase detection reaction. Read More

    Autoantibody against aldehyde dehydrogenase 2 could be a biomarker to monitor progression of Graves' orbitopathy.
    Graefes Arch Clin Exp Ophthalmol 2018 Feb 3. Epub 2018 Feb 3.
    Department of Ophthalmology, Kaohsiung Medical University Hospital, No.100, Zihyou 1st Road, Sanmin District, Kaohsiung, 807, Taiwan.
    Purpose: This study surveyed the novel autoantigens expressed in the orbital fat tissue of patients with Graves' orbitopathy (GO) and explored the possibility of the autoantibodies against novel autoantigens as biomarkers for GO.

    Methods: We used immuno-proteomic methods to survey novel autoantigens expressed in the orbit fat tissue of GO patients and confirmed by enzyme-linked immunosorbent assay (ELISA).

    Results: One protein spot (aldehyde dehydrogenase 2 (ALDH2)) revealed high reactivity with the GO serum than did the healthy control serum and was further verified by ELISA. Read More

    ANCA positive relapsing polychondritis, Graves disease, and suspected moyamoya disease: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9378
    Department of Rheumatology and Immunology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, P.R. China.
    Ratioinale: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Read More

    Insulin autoimmune syndrome in a pregnant female: A rare case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9213
    Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS.

    Patient Concerns: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. Read More

    Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial.
    Ann Am Thorac Soc 2018 Feb;15(2):250-257
    4 Berry Consultants, LLC, Austin, Texas.
    Septic shock carries substantial morbidity and mortality. The failure of many promising therapies during late-phase clinical trials prompted calls for alternative trial designs. We describe an innovative trial evaluating selepressin, a novel selective vasopressin Vreceptor agonist, for adults with septic shock. Read More

    Early Stage Graves' Disease is Uniformly Accompanied by Orbital Immune Activity even in Patients who Fail to Develop Orbithopathy during Follow-up.
    Exp Clin Endocrinol Diabetes 2018 Jan 31. Epub 2018 Jan 31.
    Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Purpose: Graves' orbitopathy (GO) is a complication of Graves' disease (GD), the development of which cannot be predicted at the time of diagnosis of GD. Our aims were (i) to test if orbitalTc-labelled diethylenetriamine pentaacetic acid single-photon emission computer tomography (DTPA SPECT) can predict development of GO later during the course of the disease and (ii) to study whether orbital immune activity can be detected in GD patients who do not develop GO during follow-up.

    Methods: Fifty-four orbits of 27 patients with newly diagnosed GD were entered into the case-control study. Read More

    Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan.
    Pediatr Diabetes 2018 Jan 31. Epub 2018 Jan 31.
    Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
    Background: Type 1 diabetes (T1D) mellitus is an autoimmune disorder involving both complex genetic and environmental factors. The incidence rates are low in Asian countries, and the specific, explanatory genetic factors underlying this have been investigated. The aim of this study was to elucidate the association of human leukocyte antigen (HLA) alleles/haplotypes with T1D in Taiwan. Read More

    Thyroid-associated orbitopathy in patients with thyroid carcinoma: A case report of 5 cases.
    Medicine (Baltimore) 2017 Nov;96(47):e8768
    Department of Internal Medicine.
    Rationale: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. Read More

    Case report: IgG4-related mass-forming thyroiditis accompanied by regional lymphadenopathy.
    Diagn Pathol 2018 Jan 3;13(1). Epub 2018 Jan 3.
    Division of Diagnostic Pathology/Surgical Pathology, University of Fukui Hospital, Eiheiji, Japan.
    Background: It has been recently accepted that IgG4-related thyroiditis is comparable to the Hashimoto and Riedel thyroiditis and Graves disease which are rich in IgG4-secreting plasma cells. Many physicians believe that in IgG4-related thyroiditis, the thyroid is entirely enlarged and diffusely affected, which is similar to conventional thyroiditis, but rarely ever accompanied by pseudoneoplastic mass formation as in IgG4-related disease in the other organs. This report introduces another pattern of IgG4-related thyroiditis as mass-forming thyroiditis and presents the occurrence of IgG4-related regional lymphadenopathy as an unusual accompanying symptom. Read More

    Multimodal assessment of orbital immune cell infiltration and tissue remodeling during development of graves disease byHF MRI.
    Magn Reson Med 2018 Jan 27. Epub 2018 Jan 27.
    Molecular Ophthalmology.
    Purpose: To evaluate key molecular and cellular features of Graves orbitopathy (GO) by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling.

    Methods: To this end, we utilized a murine model of GO induced by immunization with a human thyroid-stimulating hormone receptor A-subunit plasmid. Altogether, 52 mice were used: 27 GOs and 25 controls (Ctrl) immunized with β-galactasidose plasmid. Read More

    Functional TSH receptor antibodies in children with autoimmune thyroid diseases.
    Autoimmunity 2018 Jan 26:1-7. Epub 2018 Jan 26.
    j Molecular Thyroid Research Laboratory, Department of Medicine I , Johannes Gutenberg University (JGU) Medical Center , Mainz , Germany.
    Introduction: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls.

    Materials And Methods: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C). Read More

    Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves' disease.
    J Pak Med Assoc 2018 Jan;68(1):3-9
    Institute of Pure and Applied Biology, Zoology Division.
    Objective: To find out a correlation between the single nucleotide polymorphisms in cluster of differentiation 28 and cluster of differentiation 40 genes with Graves' disease, if any.

    Methods: This case-control study was conducted at the Multan Institute of Nuclear Medicine and Radiotherapy, Multan, Pakistan, and comprised blood samples of Graves' disease patients and controls. Various risk factors were also correlated either with the genotype at each single-nucleotide polymorphism or with various combinations of genotypes studied during present investigation. Read More

    Postoperative hypoparathyroidism in patients after total thyroidectomy - retrospective analysis.
    Neuro Endocrinol Lett 2017 Dec 3;38(7):488-494. Epub 2017 Dec 3.
    Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
    Objectives: Hypoparathyroidism is the most frequent complication of thyroidectomy. The incidence rates of temporary and permanent postoperative hypoparathyroidism vary from 7 to more than 60% and from 0 to 9%, respectively.

    Design: The aim of the study has been to evaluate the incidence of hypoparathyroidism and clinical manifestations of hypocalcaemia after total thyroidectomy, as well as assess factors that affect the frequency of the symptomatic hypocalcaemia, and benefits resulting from the measurement of parathyroid hormone (PTH) concentration on the first day after thyroidectomy. Read More

    A Promising Modified Procedure for Upper Eyelid Retraction-Associated Graves' Ophthalmopathy: Transconjunctival Lateral Levator Aponeurectomy.
    Med Hypothesis Discov Innov Ophthalmol 2017 ;6(2):44-48
    Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
    Upper eyelid retraction is a characteristic feature of thyroid eye disease, including Graves' orbitopathy. In this study, a new surgical technique for correction of lid retraction secondary to Graves' orbitopathy is described. Sixteen eyelids of patients older than 18 years old underwent surgical correction for moderate to severe lid retraction secondary to Graves' orbitopathy. Read More

    Recurrence of Graves' disease in ectopic thyroid tissue.
    BMJ Case Rep 2018 Jan 23;2018. Epub 2018 Jan 23.
    Department of Endocrinology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.
    A 40-year-old woman with a history of Graves' disease status postorbital decompression for severe ophthalmopathy underwent total thyroidectomy by a high volume thyroid surgeon in July 2013 with a benign final pathology. Eight months later, she presented with a mass on the right anterior neck that showed minimal growth over time. Her thyroid stimulating immunoglobulin and thyroid-stimulating hormone receptor antibody levels were consistently elevated and increasing. Read More

    Dental disease and dietary isotopes of individuals from St Gertrude Church cemetery, Riga, Latvia.
    PLoS One 2018 24;13(1):e0191757. Epub 2018 Jan 24.
    Institute of Latvian History, University of Latvia, Riga, Latvia.
    This research explores oral health indicators and stable carbon and nitrogen isotope data to explore diet, and differences in diet, between people buried in the four different contexts of the St Gertrude Church cemetery (15th- 17th centuries AD): the general cemetery, two mass graves, and a collective mass burial pit within the general cemetery. The main aim is to assess whether people buried in the mass graves were rural immigrants, or if they were more likely to be the victims of plague (or another epidemic) who lived in Riga and its suburbs. The data produced (from dental disease assessments and isotope analyses) were compared within, as well as between, the contexts. Read More

    Biased signaling by thyroid-stimulating hormone receptor-specific antibodies determines thyrocyte survival in autoimmunity.
    Sci Signal 2018 Jan 23;11(514). Epub 2018 Jan 23.
    Thyroid Research Unit, Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY 10029, USA.
    The thyroid-stimulating hormone receptor (TSHR) is a heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR). Autoimmune hyperthyroidism, commonly known as Graves' disease (GD), is caused by stimulating autoantibodies to the TSHR. We previously described TSHR-specific antibodies (TSHR-Abs) in GD that recognize linear epitopes in the cleavage region of the TSHR ectodomain (C-TSHR-Abs) and induce thyroid cell apoptosis instead of stimulating the TSHR. Read More

    Sequential occurrence of Graves' disease and immune thrombocytopenic purpura as manifestations of immune reconstitution inflammatory syndrome in an HIV-infected patient.
    Int J STD AIDS 2018 Jan 1:956462417752824. Epub 2018 Jan 1.
    2 Department of General Medicine, Kochi Medical School Hospital, Nankoku, Japan.
    Immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients after initiating antiretroviral therapy usually involves worsening manifestations of overt infectious disease. Here, we describe a sporadic case of a late-diagnosed HIV-positive man who developed Graves' disease as the first noninfectious IRIS followed by immune thrombocytopenic purpura as the second noninfectious IRIS. Read More

    [Struma ovarii associated with Graves' disease].
    Medicina (B Aires) 2018 ;78(1):44-46
    Servicio de Endocrinología, Servicio de Endocrinología y Metabolismo, Complejo Médico Churruca-Visca, Buenos Aires, Argentina.
    Hyperthyroidism is defined as an excessive production of thyroid hormones by eutopic or ectopic mature thyroid tissue. The overall prevalence of hyperthyroidism is 1.2% and the most common cause is Graves' disease. Read More

    Thyroid Isthmus Length and Iodine Turnover as Predictors of Successful Radioactive Iodine Therapy in Patients with Graves' Disease.
    Int J Endocrinol 2017 5;2017:7354673. Epub 2017 Dec 5.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
    Radioactive iodine (RAI) therapy is an effective treatment option for Graves' disease. However, predicting treatment failures after RAI therapy remains controversial. The objective of this study was to investigate the factors associated with the success rate of RAI therapy for treatment of Graves' hyperthyroidism. Read More

    Does hyperthyroidism worsen prognosis of thyroid carcinoma? A retrospective analysis on 2820 consecutive thyroidectomies.
    J Otolaryngol Head Neck Surg 2018 Jan 22;47(1). Epub 2018 Jan 22.
    Department of Surgical Sciences, University of Cagliari, Cittadella Universitaria, SS554, Bivio Sestu, 09042, Monserrato (CA), Italy.
    Background: Hyperthyroidism is associated with high incidence of thyroid carcinoma; furthermore, tumors arisen in hyperthyroid tissue show an aggressive behavior. Thyroid Stimulating Hormone (TSH) and Thyroid-stimulating antibodies, present in Graves's disease, seem to play a key role in carcinogenesis and tumoral growth.

    Methods: We retrospectively reviewed our series of patients who underwent thyroidectomy for thyroid carcinoma. Read More

    Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study.
    Ann Intern Med 2018 Jan 23. Epub 2018 Jan 23.
    From Health Insurance Review and Assessment Service, Wonju-si, Gangwon-do, and Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Untreated or insufficiently treated Graves disease in pregnancy may pose risks to both mother and fetus. Antithyroid drugs (ATDs) are the treatment mainstay, but the potential teratogenic effect of these drugs has prompted clinicians to question the safe management of this vulnerable population.

    Objective: To examine the association between maternal prescriptions for ATDs and congenital malformations in live births. Read More

    RE: Novel Application of Quantitative Single-Photon Emission Computed Tomography/Computed Tomography to Predict Early Response to Methimazole in Graves' Disease.
    Korean J Radiol 2018 Jan-Feb;19(1):185-186. Epub 2018 Jan 2.
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Hospital of Chinese Medicine, Guangdong Province 510120, P.R. China.

    I-Induced Graves' disease in patients treated for toxic multinodular goitre: systematic review and descriptive analysis.
    J Endocrinol Invest 2018 Jan 20. Epub 2018 Jan 20.
    Endocrinology, Diabetes and Metabolism Unit, Department of Internal Medicine, Hospital of Egas Moniz, Lisbon's Occidental Center of Hospitals, Estrada do Forte do Alto do Duque, 1449-005, Lisbon, Portugal.
    Background: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes.

    Methods: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (I-IGD) in adults.

    Results: I-IGD developed in 0-5. Read More

    Indications for the Surgical Management of Benign Goiter in Adults.
    Dtsch Arztebl Int 2018 Jan;115(1-02):1-7
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital of Giessen and Marburg; Marburg; Department of Nuclear Medicine, University Hospital of Giessen and Marburg; Marburg; German Society for General and Visceral Surgery, Berlin; Department of General and Visceral Surgery, Sana Klinikum Offenbach; Offenbach; Department of General, Visceral and Vascular Surgery, University Hospital of Würzburg; Würzburg; Department of General, Visceral and Endocrine Surgery, Lukaskrankenhaus Neuss; Neuss.
    Background: Thyroidectomy is still three to six times more common in Germany than in the USA, Great Britain, and the Scandinavian countries. Thus, the question is often asked whether thyroidectomy in Germany is being performed for the correct indications.

    Methods: This review is based on studies and guidelines containing information on the indications for surgery in benign goiter and Graves' disease; these publications were retrieved by a systematic literature search in the Medline and Cochrane Library databases (1990-2016). Read More

    Atypical phenotypic aspects of autoimmune thyroid disorders in young patients with Turner syndrome.
    Ital J Pediatr 2018 Jan 17;44(1):12. Epub 2018 Jan 17.
    Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
    Aim of this commentary is to analyze the current views about the phenotypic features of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in Turner syndrome (TS) girls, in terms of epidemiology, clinical and biochemical presentation, long-term course and metamorphic autoimmunity evolution. In TS GD course is not atypical, whereas HT course is characterized by both a mild presenting picture and a severe long-term evolution of thyroid function tests. Furthermore, TS girls seem to have an increased risk of switching over time from HT to GD. Read More

    Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies.
    Endocrinol Diabetes Metab Case Rep 2018 5;2018. Epub 2018 Jan 5.
    Department of Internal Medicine, Hospital General de Segovia, Segovia, Spain.
    Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU. Read More

    Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
    Thyroid 2018 Feb 8. Epub 2018 Feb 8.
    1 Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University , Shenyang, Liaoning, P.R. China .
    Background: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune disorders. The aims of this study were to identify global DNA methylation patterns in patients with autoimmune thyroid diseases and to observe methylation changes after treatment for these conditions.

    Methods: A cross-sectional study was conducted, including the following patients: 51 with newly diagnosed Graves' disease (GD), 28 with autoimmune hypothyroidism (AIT), 29 with positive thyroid autoantibodies, and 39 matched healthy volunteers. Read More

    High Serum Cholesterol Is a Novel Risk Factor for Graves' Orbitopathy: Results of a Cross-Sectional Study.
    Thyroid 2018 Feb 9. Epub 2018 Feb 9.
    1 Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa , Pisa, Italy .
    Background: Limited data suggest that treatment with statins is associated with a reduced risk of Graves' orbitopathy (GO) in patients with Graves' disease (GD), attributed to the anti-inflammatory rather than to the hypolipemic effects of these medications. The aim of the present study was to investigate whether there is an association between high cholesterol and GO. The primary outcome was the relation between GO and low-density lipoprotein (LDL)-cholesterol. Read More

    Family history of autoimmune diseases and risk of gastric cancer: a national cohort study.
    Eur J Cancer Prev 2018 Jan 12. Epub 2018 Jan 12.
    Department of Medicine, Center for Primary Healthcare Research, Lund University, Lund, Sweden.
    A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the familial risk of gastric cancer among individuals with a family history of a set of autoimmune diseases. Read More

    Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy.
    BMC Ophthalmol 2018 Jan 12;18(1). Epub 2018 Jan 12.
    Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary.
    Background: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease.

    Case Presentation: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy. Read More

    1 OF 408