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    Graves' disease presenting as severe postpartum pruritus.
    BMJ Case Rep 2018 Jun 15;2018. Epub 2018 Jun 15.
    Family Medicine, Saint Joseph Hospital Family Medicine Residency, Denver, Colorado, USA.
    A 39-year-old multigravida woman presented 3 weeks postpartum with worsening generalised pruritus without primary rash. Workup was significant for cholestasis and undiagnosed Graves' disease. She began to have symptomatic relief after starting methimazole, and liver function tests normalised as she became euthyroid. Read More

    Surgical Treatment of Diplopia in Graves Orbitopathy Patients.
    Ophthalmic Plast Reconstr Surg 2018 Jun 13. Epub 2018 Jun 13.
    Department of Ophthalmology, Orbital Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Purpose: To review the authors' current understanding of motility dysfunction in patients with thyroid eye disease and to summarize appropriate evaluation and available management options.

    Methods: Data were retrieved from a systematic search of the literature.

    Results: Diplopia is one of the most disabling symptoms for Graves orbitopathy patients. Read More

    Case report of recurrent atrial fibrillation induced by thyrotropin-secreting pituitary adenoma with Graves' disease.
    Medicine (Baltimore) 2018 Jun;97(24):e11047
    Department of Endocrinology and Metabolism.
    Rationale: Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring of complications. Graves' disease is an auto-immue endocrinological disorder. Read More

    Administration of thiamazole for Graves' disease might trigger the onset of type 1 diabetes.
    J Diabetes Investig 2018 Jun 14. Epub 2018 Jun 14.
    Department of Endocrinology and Diabetes, Biomedical Research Center, Saitama Medical University, Moroyama, Saitama, Japan.
    Thiamazole might trigger the onset of type 1 diabetes. Read More

    Association of FoxP3 promoter polymorphisms with the risk of Graves' disease in ethnic Kashmiri population.
    Gene 2018 Jun 8. Epub 2018 Jun 8.
    Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India. Electronic address:
    Graves' disease is a multifactorial autoimmune disorder of the thyroid gland, with some extra-thyroidal complications like eye and skin abnormalities in some patients. GD is more prevalent in women than men and is the leading cause of hyperthyroidism worldwide. A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals. Read More

    ANNALS EXPRESS: Does thyrotoxic periodic paralysis have a genetic predisposition? A case report.
    Ann Clin Biochem 2018 Jan 1:4563218785395. Epub 2018 Jan 1.
    AMNCH Tallaght Hospital.
    Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism where increased influx of potassium into skeletal muscle cells leads to profound hypokalaemia and paralysis. Most cases arise sporadically in Asians however it is being increasingly reported in Caucasians. TPP is regarded as a channelopathy where a genetic and/or acquired defect in the sodium-potassium (Na+/K+-ATPase) pump renders it more sensitive to excess thyroid hormone in susceptible individuals. Read More

    Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases.
    PLoS One 2018 7;13(6):e0198693. Epub 2018 Jun 7.
    The Second Department of Orthopedics, Cangzhou Central Hospital, Cangzhou, China.
    Background: Based on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 G/T and rs1800587 C/T polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.

    Methods: A series of meta-analyses were carried out. After database searching, we utilized our inclusion/exclusion criteria to screen and include the eligible studies. Read More

    Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features.
    J Clin Endocrinol Metab 2018 Jun 6. Epub 2018 Jun 6.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
    Context: Alemtuzumab, a highly effective treatment for multiple sclerosis (MS), predisposes to Graves' disease (GD) with a reportedly indolent course.

    Objective: To determine the type, frequency and course of thyroid dysfunction (TD) in a cohort of alemtuzumab-treated MS patients in the UK.

    Design: Case records of alemtuzumab-treated patients who developed TD were reviewed. Read More

    Pattern of presentation of Graves' disease and response to radioiodine therapy in South African men.
    Pan Afr Med J 2018 18;29:48. Epub 2018 Jan 18.
    Division of Nuclear Medicine, Department of Medical Imaging & Clinical Oncology, Tygerberg Hospital, Western Cape Province, South Africa.
    Introduction: Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0. Read More

    Selenoproteins in human body: focus on thyroid pathophysiology.
    Hormones (Athens) 2018 Jun 5. Epub 2018 Jun 5.
    Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. Read More

    Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies.
    Cancer Manag Res 2018 21;10:1201-1207. Epub 2018 May 21.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
    Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD.

    Materials And Methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. Read More

    Anatomic Considerations in Thyroid Eye Disease.
    Ophthalmic Plast Reconstr Surg 2018 May 10. Epub 2018 May 10.
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
    Purpose: To review and summarize the clinical findings in thyroid eye disease (TED) related to the unique anatomical structures of the eyelids and orbit.

    Methods: A PubMed search was performed searching for anatomical relationships between eyelid and orbital anatomy and the clinical findings of TED.

    Results: The major clinical findings associated with TED are varied. Read More

    Cerebral venous sinus thrombosis precipitated by Graves' disease.
    BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.
    Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
    Cerebral venous sinus thrombosis usually occurs in patients with a precipitating condition such as thrombophilic disorders, pregnancy or due to medications, such as oestrogens. Some case reports have reported the co-occurrence of cerebral venous sinus thrombosis in patients with hyperthyroidism. However, the association of cerebral venous sinus thrombosis with hyperthyroidism remains contentious. Read More

    Rheumatic Disease Autoantibodies in Patients with Autoimmune Thyroid Diseases.
    Med Princ Pract 2018 Jun 4. Epub 2018 Jun 4.
    Background: Patients with autoimmune thyroid diseases (ATD) such as Graves' disease (GD) and Hashimoto thyroiditis (HT) may have non-organ specific autoantibodies such as ANA (antinuclear antibodies) and RF (rheumatoid factor).

    Aim: To study the prevalence of rheumatic autoantibodies in a group of ATD patients without known rheumatic diseases and to evaluate its association with the patients' epidemiological and treatment profile. To follow positive non-organ specific autoantibody-positive ATD individuals to investigate whether they will develop a rheumatic disorder. Read More

    Pretibial myxedema in a euthyroid patient.
    Hormones (Athens) 2018 Mar 17;17(1):133-135. Epub 2018 Apr 17.
    Division of Endocrinology, Police Medical Center of Thessaloniki, Monastiriou 326, 54121, Thessaloniki, Greece.
    Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a rare case of a biopsy-proven PM in a euthyroid patient, without history of GD or Hashimoto's thyroiditis. Assessment of commonly reported thyroid autoantibodies, such as thyroid peroxidase and thyroglobulin autoantibodies, thyroid stimulating immunoglobulins and thyroid binding inhibitory immunoglobulins, was negative. Read More

    Fake news? Biotin interference in thyroid immunoassays.
    Clin Chim Acta 2018 May 29. Epub 2018 May 29.
    Department of Endocrinology, Endokrinologikum Frankfurt, Stresemannallee 1/3, 60596 Frankfurt/Main, Germany.
    We report on a 47 year old male patient with multiple sclerosis (MS) presenting in our outpatient neurology clinic in Frankfurt/Main for therapy evaluation. Before change of treatment laboratory investigations were performed. Thyroid function tests (TFTs) with a streptavidin/biotin based immunoassay revealed severe hyperthyroidism with positive thyroid autoantibodies suggestive for Graves' disease. Read More

    The Outcome of Papillary Thyroid Cancer Associated with Graves' Disease: A Case Control Study.
    J Thyroid Res 2018 8;2018:8253094. Epub 2018 May 8.
    Department of General Surgery, Endocrine Surgery Division, Amrita Institute of Medical Sciences, Kochi, Kerala 682041, India.
    Introduction: Thyroidectomy is now a less popular therapeutic option for Graves' disease. The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves' disease are controversial. The outcome of thyroid cancers coexisting with Graves' disease is debated. Read More

    Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves' Disease.
    Int J Endocrinol 2018 3;2018:9863050. Epub 2018 May 3.
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
    Objectives: Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves' disease.

    Methods: A prospective cohort study was performed with six women newly diagnosed with Graves' disease. During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively. Read More

    Optimizing Community-Based HIV Testing and Linkage to Care for Young Persons in Metropolitan Atlanta.
    AIDS Patient Care STDS 2018 Jun;32(6):234-240
    6 Ponce Family and Youth Clinic , Grady Infectious Diseases Program, Grady Health Systems, Atlanta, Georgia .
    HIV continuum of care analyses in Georgia during 2013 revealed that 82% of adolescents and adults living with HIV knew their diagnosis and that 75% were linked to care. However, of all persons in Georgia living with HIV in 2014, only 60% had at least one HIV care visit, and just 48% were retained in care. Understanding barriers for HIV testing, linkage, and retention in youth may strengthen HIV-related encounters and improve patient outcomes. Read More

    Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy.
    Sci Rep 2018 May 30;8(1):8386. Epub 2018 May 30.
    Cardiff University, School of Medicine, Division of Infection & Immunity, Cardiff, UK.
    Graves' Disease (GD) is an autoimmune condition in which thyroid-stimulating antibodies (TRAB) mimic thyroid-stimulating hormone function causing hyperthyroidism. 5% of GD patients develop inflammatory Graves' orbitopathy (GO) characterized by proptosis and attendant sight problems. A major challenge is to identify which GD patients are most likely to develop GO and has relied on TRAB measurement. Read More

    CD34- Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Modulate TNF-α Expression in CD34+ Fibroblasts and Fibrocytes.
    Invest Ophthalmol Vis Sci 2018 May;59(6):2615-2622
    Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan, United States.
    Purpose: Orbital fibroblasts from patients with Graves' disease (GD-OF) express many different cytokines when treated with bovine thyrotropin (bTSH). The present study aimed to determine why TNF-α cannot be induced by bTSH in GD-OF.

    Methods: Fibrocytes and GD-OFs were cultivated from donors who were patients in a busy academic medical center practice. Read More

    Quadrivalent human papillomavirus vaccination in girls and the risk of autoimmune disorders: the Ontario Grade 8 HPV Vaccine Cohort Study.
    CMAJ 2018 May;190(21):E648-E655
    Department of Public Health Sciences (Liu, Lévesque), Queen's University, Kingston, Ont.; Department of Epidemiology, Biostatistics and Occupational Health (Smith), McGill University, Montréal, Que. Division of Allergy and Immunology, Department of Medicine (Ellis), Queen's University, Kingston, Ont.; Allergy Research Unit (Ellis), Kingston General Hospital, Kingston, Ont.; School of Mathematics and Statistics (Whitaker, Farrington), The Open University, Milton Keynes, UK; Vaccine Safety Section, Centre for Immunization and Respiratory Infectious Diseases (Law [retired from the Public Health Agency of Canada June 2015]), Public Health Agency of Canada, Ottawa, Ont.; Institute for Clinical Evaluative Sciences (Kwong, Lévesque), Toronto, Ont.; Public Health Ontario (Kwong), Toronto, Ont.; Department of Family and Community Medicine (Kwong), University of Toronto, Toronto, Ont.; Leslie Dan Faculty of Pharmacy (Lévesque), University of Toronto, Toronto, Ont.
    Background: Despite demonstrated effectiveness in real-world settings, concerns persist regarding the safety of the quadrivalent human papillomavirus (HPV4) vaccine. We sought to assess the risk of autoimmune disorders following HPV4 vaccination among grade 8 girls eligible for Ontario's school-based HPV vaccination program.

    Methods: We undertook a population-based retrospective cohort study using Ontario's administrative health and vaccination databases from 2007 to 2013. Read More

    Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease.
    J Stroke Cerebrovasc Dis 2018 May 24. Epub 2018 May 24.
    University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
    Background: Atherosclerosis is a systemic inflammatory disease intertwined with neovascularization. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables the assessment of plaque neovascularization. This study aimed to explore the systemic nature of atherosclerosis by assessing difference in severity of neovascularization as quantified by DCE-MRI of vertebral arteries (VAs) between patients with symptomatic and asymptomatic carotid artery disease. Read More

    Antipsychotics in Hyperthyroid-Related Psychosis: Case Report and Systematic Review.
    Neuro Endocrinol Lett 2018 Mar;39(1):65-74
    Department of Psychiatry, NYU School of Medicine, 550 1st Avenue, New York, NY, 10016, USA.
    Objectives: Hyperthyroidism has been associated with relatively rare presentations of psychotic symptoms. We report an example of the successful use of antipsychotics to manage psychotic symptoms in hyperthyroid-related psychosis. Furthermore, we systematically describe the available literature on the use of antipsychotics in this setting to determine the associated relative efficacies of the various antipsychotic agents. Read More

    Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease.
    Microbiome 2018 May 25;6(1):97. Epub 2018 May 25.
    School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
    Background: Variation in induced models of autoimmunity has been attributed to the housing environment and its effect on the gut microbiota. In Graves' disease (GD), autoantibodies to the thyrotropin receptor (TSHR) cause autoimmune hyperthyroidism. Many GD patients develop Graves' orbitopathy or ophthalmopathy (GO) characterized by orbital tissue remodeling including adipogenesis. Read More

    The interactive effects of genetic polymorphisms within LFA-1/ICAM-1/GSK-3β pathway and environmental hazards on the development of Graves' opthalmopathy.
    Exp Eye Res 2018 May 22;174:161-172. Epub 2018 May 22.
    Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China. Electronic address:
    The purpose of this investigation was to explore the combined effects of single nucleotide polymorphisms (SNPs) within LFA-1/ICAM-1/GSK-3β pathway and environmental hazards on susceptibility to Graves' opthalmopathy (GO) among a Chinese Han population. Altogether 305 GO patients and 283 Graves' disease (GD) subjects were recruited. Information relevant to the participants' age, gender, body mass index (BMI), regular physical activity, smoking history, alcohol intake, stressful work environment, stress at work, family history of thyroid disease and I treatment were summarized, and the participants' related SNPs of LFA-1/ICAM-1/GSK-3β were also detected. Read More

    Increased serum interleukin-37 (IL-37) levels correlate with oxidative stress parameters in Hashimoto's thyroiditis.
    J Endocrinol Invest 2018 May 23. Epub 2018 May 23.
    Department of Clinical and Experimental Medicine, Postgraduate School and Division of Allergy and Clinical Immunology, University of Messina, Messina, Italy.
    Purpose: Interleukin-37 (IL-37), member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves' disease. To our knowledge, no data on Hashimoto's thyroiditis (HT) are available in the literature. Read More

    Narcolepsy with cataplexy and hyperthyroidism sudden appeared after H1N1 vaccination.
    Sleep Sci 2018 Jan-Feb;11(1):34-36
    Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Unidad de Medicina del Sueño - Capital Federal - Buenos Aires - Argentina.
    Narcolepsy type 1 (NT1) is a chronic sleep disorder, characterized by excessive daytime sleepiness, cataplexy and fragmented nocturnal sleep. It is caused by a hypocretin deficiency due to a significant reduction of the neurons producing it. In the last years, it has been postulated that an autoimmune mechanism would be responsible for the destruction of these neurons in those genetically predisposed patients. Read More

    Graves' ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts.
    Arch Endocrinol Metab 2018 May 17. Epub 2018 May 17.
    Departamento de Medicina Interna, Divisão de Endocrinologia, Faculdade de Medicina de Botucatu, Universidade Estadual de São Paulo, Botucatu, SP, Brasil.
    Objective: Graves' ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. Read More

    Disease Burden and Outcome in Pediatric and Young Adults with Concurrent Graves Disease and Differentiated Thyroid Carcinoma.
    J Clin Endocrinol Metab 2018 May 18. Epub 2018 May 18.
    Division of Oncology Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.
    Context: Adults with differentiated thyroid carcinoma (DTC) and Graves Disease (GD) demonstrate a greater reported disease burden and aggressive DTC behavior. To date, no studies have examined the impact and long-term outcome of concurrent GD and DTC (GD-DTC) in pediatric and young adults.

    Design: Single institution, retrospective longitudinal cohort study between 1997-2016. Read More

    Correlation between thyroidal and peripheral blood total T cells, CD8 T cells, and CD8 T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves' ophthalmopathy.
    Endocr Res 2018 May 22:1-11. Epub 2018 May 22.
    a Department of Academic Medicine , Sydney Medical School, Nepean, The University of Sydney , Kingswood , Australia.
    Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8 T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role for autoimmunity against CollXIII has also been suggested. Read More

    Right ventricular dysfunction and pulmonary hypertension: a neglected presentation of thyrotoxicosis.
    Endocrinol Diabetes Metab Case Rep 2018 16;2018. Epub 2018 May 16.
    Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia.
    Thyrotoxicosis is associated with cardiac dysfunction; more commonly, left ventricular dysfunction. However, in recent years, there have been more cases reported on right ventricular dysfunction, often associated with pulmonary hypertension in patients with thyrotoxicosis. Three cases of thyrotoxicosis associated with right ventricular dysfunction were presented. Read More

    A retrospective cohort study: do patients with graves' disease need to be euthyroid prior to surgery?
    J Otolaryngol Head Neck Surg 2018 May 21;47(1):37. Epub 2018 May 21.
    Department of Otolaryngology - Head and Neck surgery, Jewish General Hospital, McGill University, 3755 Côte-Sainte-Catherine Road, Montreal, Quebec, H3T 1E2, Canada.
    Background: The 2016 American Thyroid Association guidelines indicate that patients with Graves' disease who undergo a thyroidectomy should be rendered euthyroid through the use of antithyroid drugs (ATD) prior to surgery to avoid complications such as a thyroid storm. At times, the use of ATDs can have limited efficacy and therefore some patients will inevitably remain biochemically hyperthyroid at the time of surgery. The aim of this study is to assess if hyperthyroid patients undergoing a thyroidectomy are at an increased risk of developing a thyroid storm in comparison to euthyroid patients. Read More

    Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
    Intern Med 2018 May 18. Epub 2018 May 18.
    Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
    We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves' disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. Read More

    Antigen-specific therapy of Graves´ disease and orbitopathy by induction of tolerance.
    Front Biosci (Landmark Ed) 2018 Jun 1;23:2044-2052. Epub 2018 Jun 1.
    Procorde, Advancecor, Fraunhoferstrasse 9a, 82152 Martinsried, Germany.
    Graves´ disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage. The disease can be modelled in mice using adenoviral immunizations with the extracellular A subunit of the TSHR, which induces a long-term stable disease state. TSHR binding cAMP-stimulatory antibodies, thyroid enlargement, elevated serum thyroxin levels, tachycardia, cardiac hypertrophy and orbitopathy are observed in these Ad-TSHR-immunized mice. Read More

    Functional diagnostics for thyrotropin hormone receptor autoantibodies: bioassays prevail over binding assays.
    Front Biosci (Landmark Ed) 2018 Jun 1;23:2028-2043. Epub 2018 Jun 1.
    King's College London Faculty of Life Sciences & Medicine Denmark Hill Campus London, SE5 9PJ UK.
    Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes. Read More

    Untangling thyroid autoimmunity through modeling and simulation.
    Front Biosci (Landmark Ed) 2018 Jun 1;23:1889-1901. Epub 2018 Jun 1.
    Department of Math, University of Wisconsin - Whitewater, Whitewater, WI USA.
    Thyroid autoimmunity is characterized by a large number of identified factors, and determining the relative importance of genetics and environment, for instance, can be difficult. In addition, the definition and progression of the individual diseases can also be challenging, and questions such as "when to begin treatment" or even "should treatment be begun" can be problematic. One approach to handling situations in which there are many factors is utilizing mathematical modeling. Read More

    Thyrotropin Receptor Antibodies-An Overview.
    Ophthalmic Plast Reconstr Surg 2018 May 2. Epub 2018 May 2.
    Department of Medicine and Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, U.S.A.
    Purpose: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. Read More

    TSH-receptor antibodies may prevent bone loss in pre- and postmenopausal women with Graves' disease and Graves' orbitopathy.
    Arch Endocrinol Metab 2018 Mar-Apr;62(2):221-226
    Department of Neurology and Neuroscience, University Hospital "St. Marina", Varna, Bulgaria.
    Objective: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). Read More

    Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
    Case Rep Rheumatol 2018 22;2018:8192021. Epub 2018 Mar 22.
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Here, we present the case of a 29-year-old woman with nasal septal perforation and positive myeloperoxidase- (MPO-) anti-neutrophil cytoplasmic antibody (ANCA). She had been diagnosed with Graves' disease and had been treated with propylthiouracil (PTU) for 14 months. A biopsy of the nasal septum revealed an infiltration of inflammatory cells, with no evidence of malignancy or granulomatous change. Read More

    Methimazole-induced ANCA-associated vasculitis with diffuse alveolar haemorrhage.
    Respirol Case Rep 2018 Jul 8;6(5):e00315. Epub 2018 May 8.
    National Hospital Organization Ibarakihigashi National Hospital Naka-gun Ibaraki Japan.
    Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) caused by methimazole (MMI) is known to be relatively rare; therefore, the optimal therapeutic approach for these cases remains to be established. A 59-year-old man who was treated with MMI for a diagnosis of Graves' disease was referred to our hospital because of progressive haemoptysis. The patient was diagnosed with diffuse alveolar haemorrhage (DAH) secondary to AAV based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum and the results of bronchoalveolar lavage fluid. Read More

    Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease.
    J Immunol 2018 Jun 11;200(12):3942-3949. Epub 2018 May 11.
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105; and Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105
    Human CD34 fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator protein (AIRE). Read More

    Chaco Canyon Dig Unearths Ethical Concerns.
    Hum Biol 2017 07;89(3):177-180
    11 Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital and Research Institute, Seattle, Washington, USA.
    The field of paleogenomics (the study of ancient genomes) is rapidly advancing, with more robust methods of isolating ancient DNA and increasing access to next-generation DNA sequencing technology. As these studies progress, many important ethical issues have emerged that should be considered when ancient Native American remains, whom we refer to as ancestors, are used in research. We highlight a 2017 article by Kennett et al. Read More

    Thrombotic thrombocytopenic purpura possibly triggered by Graves' disease.
    Oxf Med Case Reports 2017 Oct 24;2017(10):omx057. Epub 2017 Oct 24.
    Division of Hematology and Oncology, Department of Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, NY, USA.
    Thrombotic thrombocytopenic purpura (TTP) is a part of a spectrum of thrombotic microangiopathy syndromes which are mainly characterized by platelet aggregation causing microangiopathic hemolytic anemia, thrombocytopenia and microvascular occlusion. In literature, very few cases expressing a direct association between pre-existing Grave's disease and TTP have been described. A 37-year-old African-American woman with past medical history of Grave's disease and polysubstance abuse who presented with complaints of dyspnoea at rest and chest pain was diagnosed to have TTP on further evaluation. Read More

    Graves' orbitopathy after allogeneic bone marrow transplantation in a patient with Fanconi anemia - side effect of alemtuzumab therapy?
    Clin Case Rep 2018 May 12;6(5):867-870. Epub 2018 Mar 12.
    Endocrinology Carol Davila University of Medicine and Pharmacy Bucharest Romania.
    A few cases of thyroid eye disease following alemtuzumab therapy have been described in patients with multiple sclerosis. Our patient is the first case of Graves' orbitopathy after alemtuzumab conditioning for hematopoietic stem cell transplantation. Read More

    New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor.
    F1000Res 2018 1;7:134. Epub 2018 Feb 1.
    Department of Ophthalmology and Visual Sciences, Kellogg Eye Center and Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
    Thyroid-associated ophthalmopathy (TAO), a localized periocular manifestation of the autoimmune syndrome known as Graves' disease, remains incompletely understood. Discussions of its pathogenesis are generally focused on the thyrotropin receptor, the proposed role for which is supported by substantial evidence. Considerations of any involvement of the insulin-like growth factor-I receptor (IGF-IR) in the disease are frequently contentious. Read More

    Bilateral, Asymmetric Keratoconus Induced by Thyrotoxicosis With Long-term Stability After Corneal Cross-linking.
    J Refract Surg 2018 May;34(5):354-356
    Purpose: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL).

    Methods: Case report and literature review.

    Results: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye. Read More

    Bilateral Keratoconus Induced by Secondary Hypothyroidism After Radioactive Iodine Therapy.
    J Refract Surg 2018 May;34(5):351-353
    Purpose: To present a case of new-onset, bilateral, rapidly progressive keratoconus induced by secondary hypothyroidism after radioactive iodine therapy during the sixth decade of life that was successfully treated with corneal cross-linking.

    Methods: Case report and literature review.

    Results: A 53-year-old woman with no ocular complaints but with a history of Graves' disease and thyrotoxicosis was treated with radioactive iodine therapy and oral levothyroxine for secondary acquired hypothyroidism 3 years prior. Read More

    Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease.
    AJP Rep 2018 Apr 4;8(2):e85-e88. Epub 2018 May 4.
    Section of Neonatology, Department of Pediatrics, University of Calgary, Cumming School of Medicine, Alberta, Canada.
    Neonatal hyperthyroidism is rare disorder due to the passage of thyroid receptor antibodies (TRBs) from the mother to the fetus. Neonatal thyrotoxicosis can present in several ways and if unrecognized, can be fatal. We present a preterm neonate who developed fetal hydrops and tricuspid regurgitation in utero. Read More

    Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.
    Dis Markers 2018 15;2018:7010196. Epub 2018 Mar 15.
    Department of Ophthalmology, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, Switzerland.
    Background: Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves' disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. Read More

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