20,980 results match your criteria Graves Disease


The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series.

Autoimmun Rev 2019 Jan 10. Epub 2019 Jan 10.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address:

Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.10.001DOI Listing
January 2019

Can preoperative vitamin D deficiency predict postoperative hypoparathyroidism following thyroid surgery?

Langenbecks Arch Surg 2019 Jan 14. Epub 2019 Jan 14.

Department of Endocrine Surgery, Catholic Hospital Mainz, An der Goldgrube 11, 55131, Mainz, Germany.

Importance: Postoperative hypoparathyroidism remains a relevant problem after thyroid surgery. Although the roles of vitamin D deficiency and other risk factors have been discussed in previous studies, variable results have been reported.

Objective: Predicting the risk of postoperative hypocalcemia could be helpful for individual prognoses and medical treatment. Read More

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http://dx.doi.org/10.1007/s00423-019-01748-3DOI Listing
January 2019

A marked goiter involved in Marine-Lenhart syndrome.

J Gen Fam Med 2019 Jan 24;20(1):37-38. Epub 2018 Nov 24.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Marine-Lenhart syndrome is rare disease defined as coexistence of Graves' disease and autonomously functioning thyroid nodule. We will introduce a case of Marine-Lenhart with a huge goiter. Read More

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http://dx.doi.org/10.1002/jgf2.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321827PMC
January 2019

Temperature changes associated with bone drilling in an orbital model: comparison of ultrasonic bone curette and conventional high-speed rotational drill.

Orbit 2019 Jan 10:1-7. Epub 2019 Jan 10.

a Wilmer Eye Institute , Baltimore , MD , USA.

Purpose: Thermal injury to the optic nerve is a potential complication of bony decompression of the orbital apex. An animal model was used to compare and contrast temperature change while removing orbital bone with ultrasonic and conventional drills.

Methods: Two devices, Sonopet ultrasonic bone curette and TPS CORE Micro drill, were used to remove bone from six unpreserved exenterated porcine orbits at fixed distances from the optic canal while temperature was recorded. Read More

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http://dx.doi.org/10.1080/01676830.2018.1558267DOI Listing
January 2019

Hyperthyroidism with Biventricular Heart Failure and Cirrhotic Transformation of the Liver.

Case Rep Cardiol 2018 9;2018:3861340. Epub 2018 Dec 9.

Reading Hospital, Tower Health System, West Reading, PA, USA.

Cardiovascular symptoms remain the most common presenting features and leading causes of death in hyperthyroidism. We report a young female with reported thyroid disease and medication noncompliance presenting with atrial fibrillation, severe atrioventricular regurgitation, severely dilated right heart with reduced function, and moderate pulmonary hypertension (PH), which was further complicated by congestive liver injury with ascites and pancytopenia. Thyroid work-up revealed suppressed TSH, elevated free T4 and T3 along with elevated anti-thyroglobulin antibodies, thyroid peroxidase antibodies, and thyroid-stimulating immunoglobulin, suggesting Graves' thyrotoxicosis. Read More

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http://dx.doi.org/10.1155/2018/3861340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305034PMC
December 2018

Corticosteroids in Moderate-To-Severe Graves' Ophthalmopathy: Oral or Intravenous Therapy?

Int J Environ Res Public Health 2019 Jan 8;16(1). Epub 2019 Jan 8.

Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy.

Background: Ophthalmopathy is a rare extra-thyroid manifestation of Graves' disease, in paediatrics. Intravenous corticosteroids are the main treatment of moderate-to-severe Graves' orbitopathy. In this paper, we describe a moderate-to-severe active Graves' ophthalmopathy in a child and the response to oral therapy with prednisone. Read More

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http://dx.doi.org/10.3390/ijerph16010155DOI Listing
January 2019

Conversion to Graves disease from Hashimoto thyroiditis: a study of 24 patients.

Arch Endocrinol Metab 2018 ;62(6):609-614

Department of Endocrinology, CHU, Liège, Belgium.

Objective: The conversion of Hashimoto's thyroiditis (HT) to hyperthyroidism due to thyrotropin receptor antibodies is intriguing and considered rare. The contribution of TSH receptor blocking antibodies (TRAb), which may be stimulators (TSAb) or blockers (TBAb), is suspected. We describe clinical and biological variables in a series of patients switching from Hashimoto's thyroiditis to Grave's disease. Read More

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http://dx.doi.org/10.20945/2359-3997000000086DOI Listing
January 2018

Severe unilateral orbitopathy in a patient with Hashimoto's thyroiditis - a case report.

BMC Ophthalmol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland.

Background: Thyroid-associated orbitopathy (TAO) constitutes an immune-mediated inflammation of the orbital tissues of unclear etiopathogenesis. TAO is most prevalent in hyperthyroid patients with Graves' disease (GD); however, severe cases of orbitopathy associated with Hashimoto's thyroiditis (HT) have rarely been described.

Case Presentation: Herewith we report an unusual case of a middle-aged clinically and biochemically euthyroid woman with a stable HT, who developed a severe unilateral left-sided TAO. Read More

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http://dx.doi.org/10.1186/s12886-018-1018-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325776PMC
January 2019
3 Reads

Therapeutic effects of short cyclic and combined epitope peptides in a long-term model of Graves´ disease and orbitopathy.

Thyroid 2019 Jan 8. Epub 2019 Jan 8.

Fraunhofer Strasse 9a82152 MartinsriedMartinsried, Germany , 82152 ;

Cyclic peptides derived from some cylindrical loops of the leucin-rich repeat domain (LRD) of the thyroid-stimulating hormone receptor (TSHR) have been shown to treat disease manifestations in a mouse model of Graves´ disease during a long-term protocol of 4-weekly immunisations with adenovirus coding for the TSHR A subunit (Ad-TSHR289). In a follow-up study, we tested two additional cyclic peptides which were shortened in order to obtain additional information on the minimally involved epitopes, and to enable easier production conditions. In addition, we tested a linear peptide which mimics parts of three loops of the native TSHR LRD structure, and is potentially able to block the discontinuous epitopes of anti-TSHR antibodies. Read More

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http://dx.doi.org/10.1089/thy.2018.0326DOI Listing
January 2019

Nature of coexisting thyroid autoimmune disease determines success or failure of tumor immunity in thyroid cancer.

J Immunother Cancer 2019 Jan 7;7(1). Epub 2019 Jan 7.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism and Center for Diabetes and Endocrine Research (CeDER), University of Toledo, College of Medicine and Life Sciences, 3000 Arlington Ave., M.S. 1186, Toledo, OH, 43614, USA.

Background: Thyroid cancer and thyroid autoimmunity are considered opposite extremes of immune-responses. However, several studies have suggested that thyroid cancer coexists with autoimmune thyroid diseases like Hashimoto Thyroiditis (HT) and Graves disease (GD). We have shown that the risk of developing thyroid cancer is higher in patients with a silent form of autoimmune thyroid disease -Euthyroid Hashimoto Thyroiditis-(EHT). Read More

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http://dx.doi.org/10.1186/s40425-018-0483-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323721PMC
January 2019

A statistical measure for the skewness of X chromosome inactivation based on case-control design.

BMC Bioinformatics 2019 Jan 7;20(1):11. Epub 2019 Jan 7.

State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Biostatistics, School of Public Health, Southern Medical University, No. 1023, South Shatai Road, Baiyun District, Guangzhou, 510515, China.

Background: Skewed X chromosome inactivation (XCI), which is a non-random process, is frequently observed in both healthy and affected females. Furthermore, skewed XCI has been reported to be related to many X-linked diseases. However, no statistical method is available in the literature to measure the degree of the skewness of XCI for case-control design. Read More

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http://dx.doi.org/10.1186/s12859-018-2587-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323862PMC
January 2019

Establishment of clinical diagnosis model of Graves' disease and Hashimoto's thyroiditis.

J Transl Med 2019 Jan 7;17(1):11. Epub 2019 Jan 7.

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.

Background: A clinical diagnosis model include thyroid functions, thyroid antibodies and radioactive iodine uptake (RAIU) of patients with hyperthyroidism were established and as new evaluation indicators for the differentiation of the Graves' disease (GD) and Hashimoto's thyroiditis (HT).

Methods: Clinical data of patients with newly diagnosed hyperthyroidism including gender, age, thyroid function, thyroid antibodies (FT3, FT4, TSH, TPOAb, TGAb, TRAb), RAIU (2 h, 6 h, 24 h) were collected. A stepwise regression analysis was performed to establish a model based on these variables. Read More

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http://dx.doi.org/10.1186/s12967-018-1765-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322254PMC
January 2019

The relationship between thyroid eye disease and radioiodine treatment.

Nucl Med Commun 2019 Jan 5. Epub 2019 Jan 5.

Department of Nuclear Medicine, National Cancer Center, Calmette University Hospital, Phnom Penh, Cambodia.

Thyroid eye disease is the most frequent extrathyroidal manifestation of Graves' disease and it can have a major negative impact on the quality of life of affected patients. Therefore, it is crucial to have a correct and early diagnosis. Thyroid eye disease management should be multidisciplinary. Read More

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http://Insights.ovid.com/crossref?an=00006231-900000000-9845
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http://dx.doi.org/10.1097/MNM.0000000000000965DOI Listing
January 2019
3 Reads

GEOFIL: A spatially-explicit agent-based modelling framework for predicting the long-term transmission dynamics of lymphatic filariasis in American Samoa.

Epidemics 2018 Dec 29. Epub 2018 Dec 29.

Research School of Population Health, The Australian National University, Australia.

In this study, a spatially-explicit agent-based modelling framework GEOFIL was developed to predict lymphatic filariasis (LF) transmission dynamics in American Samoa. GEOFIL included individual-level information on age, gender, disease status, household location, household members, workplace/school location and colleagues/schoolmates at each time step during the simulation. In American Samoa, annual mass drug administration from 2000 to 2006 successfully reduced LF prevalence dramatically. Read More

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http://dx.doi.org/10.1016/j.epidem.2018.12.003DOI Listing
December 2018
1 Read

Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy.

Clin Exp Med 2019 Jan 4. Epub 2019 Jan 4.

Immunoendocrinology, EndoMed, Bem tér 18/C., Debrecen, 4026, Hungary.

Graves' disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves' hyperthyroidism is characterized by T dominance due to the conversion of T into T through type 1 and 2 deiodinase enzymes (DIO1, DIO2). Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes. Read More

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http://dx.doi.org/10.1007/s10238-018-00542-7DOI Listing
January 2019
3 Reads

Q fever vaccination of children in Australia: Limited experience to date.

J Paediatr Child Health 2019 Jan 2. Epub 2019 Jan 2.

Infection Management and Prevention Service, Lady Cilento Children's Hospital, Brisbane, Queensland, Australia.

Aim: Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii and is associated with significant morbidity and mortality in both adults and children. Australia is the only country that has produced and registered a Q fever vaccine for human use, but this vaccine is licenced only for people aged over 15 years as data and experience in children are limited. This review describes the experience of Q fever vaccination of known paediatric cases in Australia to date. Read More

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http://dx.doi.org/10.1111/jpc.14364DOI Listing
January 2019
1 Read

Thyroid stunning in radioiodine-131 therapy of benign thyroid diseases.

Endocrine 2018 Dec 31. Epub 2018 Dec 31.

Department of Nuclear Medicine, University Hospital Frankfurt, Theodor Stern Kai 7, D-60590, Frankfurt, Germany.

Purpose: Existence and cause of thyroid stunning was controversially discussed for decades but the underlying mechanism remains unclear. Numerous studies describe thyroid stunning in radioiodine-131 therapy (RIT) of differentiated thyroid carcinoma. However, there are no studies evaluating thyroid stunning in benign thyroid diseases caused by the radioiodine uptake test (RIUT). Read More

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http://dx.doi.org/10.1007/s12020-018-01833-5DOI Listing
December 2018
1 Read

Corticosteroids for Graves' Ophthalmopathy: Systematic Review and Meta-Analysis.

Biomed Res Int 2018 22;2018:4845894. Epub 2018 Nov 22.

Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Graves' ophthalmopathy (GO) is a complicated autoimmune disease. Various therapies have been used to manage GO; however the optimum therapy is not clear. Glucocorticoids (GCs) therapy is the mainstay of treatment especially for active moderate to severe patients, which needs evidence-based support. Read More

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http://dx.doi.org/10.1155/2018/4845894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282115PMC
November 2018
2 Reads

Graves' Thyrotoxicosis Leading to Adrenal Decompensation and Hyperandrogenemia in a Pediatric Patient with Salt-Wasting Congenital Adrenal Hyperplasia.

Case Rep Endocrinol 2018 22;2018:2359205. Epub 2018 Nov 22.

Pediatric Endocrinology, Rhode Island Hospital/The Warren Alpert Medical School of Brown University, 111 Plain Street, 3rd Floor, Providence, RI 02903, USA.

Introduction: Thyroid hormone is known to accelerate glucocorticoid turnover. In a thyrotoxic state, individuals with adrenal insufficiency are unable to increase endogenous cortisol production to compensate for increased turnover, placing them at risk for symptoms of glucocorticoid deficiency and adrenal crisis. In patients with salt-wasting congenital adrenal hyperplasia (SW-CAH), hyperandrogenemia is a measurable reflection of relative glucocorticoid insufficiency. Read More

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http://dx.doi.org/10.1155/2018/2359205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282132PMC
November 2018
1 Read

Carotid Artery Function Is Restored in Subjects With Elevated Cardiovascular Disease Risk After a 12-Week Physical Activity Intervention.

Can J Cardiol 2019 Jan 14;35(1):23-26. Epub 2018 Nov 14.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Sympathetic nervous system activation elicits carotid artery vasodilation in healthy subjects, yet vasoconstriction in those with cardiovascular disease (CVD). Whether carotid artery vasoconstriction can be reversed is currently unknown. Nineteen subjects with increased risk for CVD were referred to a 12-week physical activity intervention, and 12 participants with increased risk for CVD were recruited as a no treatment control group. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.015DOI Listing
January 2019

Associations of SPP1 and BLK gene polymorphisms with autoimmune thyroid disease.

Eur J Clin Invest 2018 Dec 27:e13065. Epub 2018 Dec 27.

Division of Endocrinology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: Dysregulation of the type 1 interferon (IFN)-related signaling pathway predisposes one to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of Secreted phosphoprotein 1 (SPP1) and B lymphocyte kinase (BLK) of the type 1 IFN-related signaling pathway with autoimmune thyroid disease (AITD) in an ethnic Chinese (i.e. Read More

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http://dx.doi.org/10.1111/eci.13065DOI Listing
December 2018
1 Read

Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts.

PLoS One 2018 21;13(12):e0209583. Epub 2018 Dec 21.

Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), along with its receptor fibroblast growth factor-inducible (Fn)14, is associated with various biological activities including inflammation. However, its role in the pathogenesis of Graves' orbitopathy (GO) is unknown. In this study, we investigated the mechanism by which TWEAK regulates inflammatory signaling in orbital fibroblasts from GO patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209583PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303076PMC
December 2018
3.234 Impact Factor

Study of Deiodinase Type 2 Polymorphisms in Graves' Disease and Ophthalmopathy in a Swedish Population.

Eur Thyroid J 2018 Nov 20;7(6):289-293. Epub 2018 Jul 20.

Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden.

Background: Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association of SNPs in DIO2 with Graves' disease (GD) was suggested in 2 Russian studies. Read More

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http://dx.doi.org/10.1159/000490892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276746PMC
November 2018

Comparison of Intra-Operative Vital Sign Changes during Total Thyroidectomy in Patients with Controlled and Uncontrolled Graves' Disease.

J Clin Med 2018 Dec 19;7(12). Epub 2018 Dec 19.

Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea.

Thyroid storm (TS) is a life-threatening emergency endocrine condition. Thyroid hormones should be normalized before thyroidectomy is performed in patients with Graves' disease. However, thyroid hormone levels are inevitably high in patients undergoing surgery. Read More

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http://dx.doi.org/10.3390/jcm7120566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306939PMC
December 2018

Insulin autoimmune syndrome: Three case reports.

Medicine (Baltimore) 2018 Dec;97(51):e13486

Department of Endocrinology, the People's Hospital of China Three Gorges University & The First People's Hospital of Yichang, Yichang, Hubei Province, China.

Rationale: Insulin autoimmune syndrome (IAS) is a rare endocrine disease characterized by repeated fasting hypoglycemia or episodes of hypoglycemia late after meals, elevated serum insulin, and positivity for insulin autoantibody (IAA) or insulin receptor antibody (IRA). We summarize the clinical manifestations and treatment experiences of 3 patients with IAS.

Patient Concerns: One patient with >20-year history of type 2 diabetes mellitus had irregular episodes of hypoglycemia 2 years of after treatment with insulin. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0002
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http://dx.doi.org/10.1097/MD.0000000000013486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320147PMC
December 2018
6 Reads
5.723 Impact Factor

Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish.

J Hepatol 2018 Dec 17. Epub 2018 Dec 17.

Department of Medical Microbiology and Immunology, University of Wisconsin Madison,Madison, United States; Department of Pediatrics, University of Wisconsin-Madison, Madison, United States. Electronic address:

Background And Aims: Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) is an increasing clinical problem associated with progression to hepatocellular carcinoma (HCC). The effect of high fat diet on the early immune response in HCC is poorly understood. In addition, the role of metformin in treating NAFLD and HCC remains controversial. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.11.034DOI Listing
December 2018

Change of surgical strategy for Graves' disease from subtotal thyroidectomy to total thyroidectomy: a single institutional experience.

Endocr J 2018 Dec 19. Epub 2018 Dec 19.

Department of Surgery, Ito Hospital, Tokyo, Japan.

The extent of thyroidectomy in Graves' disease remains controversial. In our institution, long-term euthyroidism without thyroxin replacement therapy has been the aim, and it has long been the standard surgical procedure used to treat Graves' disease in many institutions, including our hospital. Based our several clinical studies, it was concluded that subtotal thyroidectomy is not suitable as a standard surgical procedure for the treatment of Graves' disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0324DOI Listing
December 2018

Response to Letter: Elevated serum tetrac in Graves' disease: potential pathogenic role in thyroid-associated ophthalmopathy.

J Clin Endocrinol Metab 2018 Dec 18. Epub 2018 Dec 18.

Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center.

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http://dx.doi.org/10.1210/jc.2018-02282DOI Listing
December 2018
3 Reads

Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Ann Clin Transl Neurol 2018 Dec 9;5(12):1513-1521. Epub 2018 Oct 9.

Pediatric Multiple Sclerosis Center University of California San Francisco San Francisco California.

Background: There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals.

Methods: We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www. Read More

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http://dx.doi.org/10.1002/acn3.663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292189PMC
December 2018

Improving CHADS-VASc stratification of non-fatal stroke and mortality risk using the Intermountain Mortality Risk Score among patients with atrial fibrillation.

Open Heart 2018 17;5(2):e000907. Epub 2018 Nov 17.

Intermountain Heart Institute, Intermountain Medical Center, Murray, Utah, USA.

Background: Oral anticoagulation (OAC) therapy guidelines recommend using CHADS-VASc to determine OAC need in atrial fibrillation (AF). A usable tool, CHADS-VASc is challenged by its predictive ability. Applying components of the complete blood count and basic metabolic profile, the Intermountain Mortality Risk Score (IMRS) has been extensively validated. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269639PMC
November 2018

A new case of Marine-Lenhart syndrome with a papillary thyroid carcinoma.

Clin Case Rep 2018 Dec 18;6(12):2299-2302. Epub 2018 Oct 18.

Department of Clinical and Experimental Medicine Endocrine Unit University of Pisa Pisa Italy.

We report the case of a patient with the coexistence of Graves' disease and autonomously functioning thyroid nodules. Because of the suspicious ultrasound pattern, he was submitted to fine-needle aspiration of the hot nodule and cytology revealed a papillary thyroid cancer. After total thyroidectomy a papillary thyroid cancer was found. Read More

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http://dx.doi.org/10.1002/ccr3.1769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293153PMC
December 2018
1 Read

Letter to the Editor: "Elevated serum tetrac in Graves Disease: Potential pathogenic role in thyroid-associated ophthalmopathy".

J Clin Endocrinol Metab 2018 Dec 17. Epub 2018 Dec 17.

Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02103DOI Listing
December 2018
2 Reads

Thyroid and celiac disease in pediatric age: a literature review.

Acta Biomed 2018 Dec 17;89(9-S):11-16. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic autoimmune thyroid disease or Hashimoto thyroiditis (HT) and Graves-Basedow disease (GD) are the main autoimmune thyroid diseases in pediatric age. Both are characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function (hyperthyroidism in GD, normal function or subclinical hypothyroidism in HT with possible evolution towards manifest hypothyroidism). Celiac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects, its prevalence is around 1% in Western Countries. Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7872DOI Listing
December 2018
5 Reads

Mitral Chordae Rupture as a Possible First-Time Presentation for Graves’ Disease.

J Heart Valve Dis 2018 Jan;27(1):110-113

Imam Abdulrahman bin Faisal University, College of Medicine, Internal Medicine Department, Saudi Arabia. Electronic correspondence:

Graves' disease is a common cause of hyperthyroidism that can lead to multiple cardiovascular complications. Herein is described the case of a 44-year-old male who presented with new-onset atrial fibrillation and mitral regurgitation secondary to flail anterior mitral leaflet with chordae tendineae rupture. This is a rare complication for Graves' disease, and has been reported only twice previously. Read More

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January 2018
5 Reads

The Pathology of Hyperthyroidism.

Front Endocrinol (Lausanne) 2018 3;9:737. Epub 2018 Dec 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, United States.

This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00737
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http://dx.doi.org/10.3389/fendo.2018.00737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286962PMC
December 2018
5 Reads

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

J Child Neurol 2018 Dec 17:883073818815041. Epub 2018 Dec 17.

19 Pediatric Multiple Sclerosis Center at New York University Langone Medical Center, New York, NY, USA.

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2. Read More

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http://dx.doi.org/10.1177/0883073818815041DOI Listing
December 2018
5 Reads
1.666 Impact Factor

Acute schizophrenia-like psychosis as major clinical presentation of Graves’ disease successfully treated by radioiodine in combination with antipsychotics: a case report.

Actas Esp Psiquiatr 2018 Nov 1;46(6):242-8. Epub 2018 Nov 1.

Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P.R. China.

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November 2018
1 Read

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310574PMC
December 2018
5 Reads

Radioiodine treatment for graves' disease: a 10-year Australian cohort study.

BMC Endocr Disord 2018 Dec 12;18(1):94. Epub 2018 Dec 12.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Background: Radioactive iodine (I) is a common definitive treatment for Graves' Disease. Potential complications include worsening, or new development of Graves' eye disease and development of a radiation thyroiditis. The purpose of the present study was to assess outcomes of patients treated with I in an Australian tertiary centre over 10 years. Read More

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http://dx.doi.org/10.1186/s12902-018-0322-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292026PMC
December 2018

Dasatinib is preferentially active in the activated B-cell subtype of diffuse large B-cell lymphoma.

J Proteome Res 2018 Dec 12. Epub 2018 Dec 12.

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, with at least one-third of its patients relapsing after treatment with the current chemotherapy regimen, R-CHOP. By gene expression profiling, patients with DLBCL can be categorized into two clinically relevant subtypes: activated B-cell (ABC) and germinal center B-cell (GCB) DLBCL. Patients with the ABC subtype have a poorer prognosis than those with GCB, and are defined by chronic, overactive signaling through the B-cell receptor and NF-κB pathways. Read More

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00841
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http://dx.doi.org/10.1021/acs.jproteome.8b00841DOI Listing
December 2018
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Impact of different approaches to calculation of treatment activities on achieved doses in radioiodine therapy of benign thyroid diseases.

EJNMMI Phys 2018 Dec 12;5(1):32. Epub 2018 Dec 12.

Department of Nuclear Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Purpose: Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual therapy activity. Here, we analyze how absorbed tissue doses are influenced by different approaches to pretherapeutic activity calculation of varying complexity. Read More

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http://dx.doi.org/10.1186/s40658-018-0231-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289932PMC
December 2018

T2-relaxation mapping and fat fraction assessment to objectively quantify clinical activity in thyroid eye disease: an initial feasibility study.

Eye (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

Imaging in thyroid eye disease (TED) is used to exclude other diagnoses, assess for apical crowding and plan surgery. But to quantify TED activity objectively, subjective clinical scoring assessments remain the norm. Magnetic resonance imaging (MRI) T2-relaxation times correlate with extra-ocular muscle (EOM) inflammation, but are confounded by signal from fat. Read More

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http://dx.doi.org/10.1038/s41433-018-0304-zDOI Listing
December 2018

Rapid Development of Graves' Ophthalmopathy After Treatment With Ipilimumab and Recurrence With Pembrolizumab in a Patient With Previously Treated Graves' Disease.

J Oncol Pract 2018 Dec;14(12):747-749

Inova Fairfax Hospital and Inova Schar Cancer Institute, Falls Church, VA; and Seoul National University Hospital, Seoul, Republic of Korea.

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http://dx.doi.org/10.1200/JOP.18.00442DOI Listing
December 2018
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Increased risk of postoperative complications after total thyroidectomy with Graves' disease.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Ewha Womans University Medical Center, Seoul, South Korea.

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.

Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).

Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Read More

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http://dx.doi.org/10.1002/hed.25484DOI Listing
December 2018
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The MAGI2 gene polymorphism rs2160322 is associated with Graves' disease but not with Hashimoto's thyroiditis.

J Endocrinol Invest 2018 Dec 8. Epub 2018 Dec 8.

Department of Emergency, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China.

Purpose: Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune disorders, predominantly including Graves' disease (GD), and Hashimoto's thyroiditis (HT). This study aimed to investigate whether single-nucleotide polymorphisms (SNPs) in MAGI2 and MAGI3 gene contributed to the etiology of AITDs.

Methods: We conducted a case-control study including 1001 patients with AITDs (625 GD, 376 HT) and 846 healthy controls. Read More

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http://dx.doi.org/10.1007/s40618-018-0990-1DOI Listing
December 2018
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A Rare Case of Thyrotoxic Periodic Paralysis After Epidural Steroid Injection: A Case Report and Literature Review.

Am J Case Rep 2018 Dec 8;19:1453-1458. Epub 2018 Dec 8.

Department of Internal Medicine, Piedmont Athens Regional Medical Center, Athens, GA, USA.

BACKGROUND Thyrotoxic periodic paralysis (TPP) is a rare cause of acute paralysis, which if not promptly recognized and treated, can lead to significant morbidity and mortality. TPP can be precipitated by several factors, including a high carbohydrate diet and exercise. This report is of a rare case of TPP after epidural steroid injection in a young man, with a review of the literature of previous cases. Read More

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http://dx.doi.org/10.12659/AJCR.911270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293861PMC
December 2018
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Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves' disease and response to UVA-1 phototherapy.

Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.

Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More

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http://dx.doi.org/10.1111/phpp.12442DOI Listing
December 2018
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Bystander Phage Therapy: Inducing Host-Associated Bacteria to Produce Antimicrobial Toxins against the Pathogen Using Phages.

Antibiotics (Basel) 2018 Dec 4;7(4). Epub 2018 Dec 4.

Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.

is often present in beehives, including presence in hives infected with the causative agent of American Foulbrood (AFB), . In this work, 12 bacteriophages induced bactericidal products in their host. Results demonstrate that is susceptible to antimicrobials induced from field isolates of the bystander, . Read More

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http://dx.doi.org/10.3390/antibiotics7040105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315864PMC
December 2018
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Is Sjögren's syndrome dry eye similar to dry eye caused by other etiologies? Discriminating different diseases by dry eye tests.

PLoS One 2018 3;13(12):e0208420. Epub 2018 Dec 3.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS.

Methods: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277094PMC
December 2018
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Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.

Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More

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http://dx.doi.org/10.1007/s11845-018-1939-2DOI Listing
November 2018
1 Read