22,101 results match your criteria Graves Disease


Scintigraphy evaluation of hyperthyroidism and its correlation with clinical and biochemical profiles.

BMC Res Notes 2020 Jul 6;13(1):324. Epub 2020 Jul 6.

Taif University School of Medicine, Taif, Saudi Arabia.

Objective: Hyperthyroidism is the excessive synthesis of thyroid hormones. Thyroid uptake scans and ultrasonography provide an accurate diagnosis of hyperthyroidism, especially when thyroid receptor antibody (TRAb) measurement is not readily available. This study explored the prevalence of various hyperthyroidism causes using retrospective scintigraphy results and evaluated their relationship with clinical, biochemical, and sonographic imaging parameters from patients who underwent Tc-pertechnetate thyroid scans between 2016 and 2019 in Taif, Saudi Arabia, where literature is insufficient. Read More

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http://dx.doi.org/10.1186/s13104-020-05164-5DOI Listing

Serum concentrations of TNF-α and its soluble receptors in Graves' disease.

Endocr Connect 2020 Jul 1. Epub 2020 Jul 1.

D Zhang, Clinical Medicine Research Center, Nantong City No 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, China.

Graves' disease (GD), an organ-specific autoimmune disease, is the most common cause of hyperthyroidism. Tumour necrosis factor-alpha (TNF-α) exhibits immunological and metabolic activities involved in the induction and maintenance of immune responses. We attempted to evaluate the relationship between GD and serum TNF-α and its soluble receptors (sTNFRs), soluble tumour necrosis factor receptor 1 and 2 (sTNF-R1 and sTNF-R2). Read More

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http://dx.doi.org/10.1530/EC-20-0162DOI Listing

Supraorbital Neuralgia Associated With Thyroid Eye Disease.

Ophthalmic Plast Reconstr Surg 2020 Jun 17. Epub 2020 Jun 17.

Plastic Eye Surgery Associates, Houston, Texas, U.S.A.

Purpose: To identify the relationship between thyroid eye disease (TED) and supraorbital neuralgia (SON) and establish a reliable approach to the diagnosis and management of TED-associated SON.

Methods: This retrospective study included 1,126 patients. Demographics, active and inactive phase status and duration, and reactivation rate were noted. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001762DOI Listing

Graves' disease.

Nat Rev Dis Primers 2020 Jul 2;6(1):52. Epub 2020 Jul 2.

Department of Medicine I, Johannes Gutenberg University Medical Centre, Mainz, Germany.

Graves' disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism and occurs at all ages but especially in women of reproductive age. Graves' hyperthyroidism is caused by autoantibodies to the thyroid-stimulating hormone receptor (TSHR) that act as agonists and induce excessive thyroid hormone secretion, releasing the thyroid gland from pituitary control. Read More

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http://dx.doi.org/10.1038/s41572-020-0184-yDOI Listing

Graves' disease.

Authors:

Nat Rev Dis Primers 2020 Jul 2;6(1):53. Epub 2020 Jul 2.

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http://dx.doi.org/10.1038/s41572-020-0195-8DOI Listing

Coronavirus disease 2019 (COVID-19): an evidence map of medical literature.

BMC Med Res Methodol 2020 07 2;20(1):177. Epub 2020 Jul 2.

Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.

Background: Since the beginning of the COVID-19 outbreak in December 2019, a substantial body of COVID-19 medical literature has been generated. As of June 2020, gaps and longitudinal trends in the COVID-19 medical literature remain unidentified, despite potential benefits for research prioritisation and policy setting in both the COVID-19 pandemic and future large-scale public health crises.

Methods: In this paper, we searched PubMed and Embase for medical literature on COVID-19 between 1 January and 24 March 2020. Read More

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http://dx.doi.org/10.1186/s12874-020-01059-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330264PMC

Alemtuzumab-related thyroid disease in people with multiple sclerosis is associated with age and brainstem phenotype at disease onset.

Mult Scler J Exp Transl Clin 2020 Apr-Jun;6(2):2055217320933928. Epub 2020 Jun 18.

Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland.

Background: Autoimmune thyroid disease (AITD) occurs in 40%-50% of alemtuzumab-treated persons with multiple sclerosis (pwMS), most of whom will develop Graves' Disease (GD).

Objective: To explore contributory factors for alemtuzumab-related AITD in pwMS.

Methods: A retrospective patient chart review was performed. Read More

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http://dx.doi.org/10.1177/2055217320933928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307483PMC

Intractable hiccups as a rare gastrointestinal manifestation in severe endocrine and metabolic crisis: case report and review of the literature.

Ther Adv Endocrinol Metab 2020 20;11:2042018820934307. Epub 2020 Jun 20.

Department of Endocrinology and Nephrology, Chongqing Emergency Medical Hospital, Chongqing University Central Hospital, No.1 Jiankang Road, Yuzhong District, Chongqing 400014, China.

Diabetic ketoacidosis (DKA) and thyroid storm (TS) are severe metabolic and endocrine disorders. Both usually manifest with multiple systemic clinical signs and symptoms, and digestive symptoms, such as nausea and vomiting, are most common in these patients. Moreover, the presence of a concurrent severe or rare complication may worsen the condition or even cause death due to misdiagnosis, delayed diagnosis, or inappropriate treatment. Read More

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http://dx.doi.org/10.1177/2042018820934307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307285PMC

The Association Between Foxp3 Polymorphisms and Risk of Graves' Disease: A Systematic Review and Meta-Analysis of Observational Studies.

Front Endocrinol (Lausanne) 2020 16;11:392. Epub 2020 Jun 16.

Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

This systematic review and meta-analysis was carried out with the aim of investigating the relationship between Foxp3 polymorphisms (rs3761547, r3761548, and rs3761549) and the risk of Graves' disease (GD). Four online database including PubMed, EMBASE, ISI Web of Science, and CNKI were searched to identify observational studies that evaluated the association between Foxp3 polymorphisms and risk of GD. The strength of associations was indicated as odds ratio (OR) and corresponding 95% confidence interval (95%CI) under the allelic model. Read More

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http://dx.doi.org/10.3389/fendo.2020.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308555PMC

The change in the clinical presentation of Graves' disease: a 30 years retrospective survey in an academic Brazilian tertiary center.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Endocrinologia e Metabolismo, Hospital da Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas,SP, Brasil.

Objective: Graves' disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has rarely been studied. To determine changes in the clinical presentation of patients with GD in the last 30 years. Read More

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http://dx.doi.org/10.20945/2359-3997000000265DOI Listing

Antithyroid drugs and birth defects.

Thyroid Res 2020 27;13:11. Epub 2020 Jun 27.

Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark.

Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves' disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effects is known. For the use of ATDs in pregnancy, a concern about teratogenic side effects has been brought forward since the 1970s. Read More

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http://dx.doi.org/10.1186/s13044-020-00085-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320591PMC

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report.

BMC Endocr Disord 2020 Jun 30;20(1):97. Epub 2020 Jun 30.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.

Background: Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.

Case Presentation: A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Read More

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http://dx.doi.org/10.1186/s12902-020-00583-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324972PMC

Is only Thyroid Peroxidase Antibody Sufficient for Diagnosing Chronic Lymphocytic Thyroiditis?

Sisli Etfal Hastan Tip Bul 2018 8;52(2):97-102. Epub 2018 Jun 8.

Department of Endocrinology and Metabolism, Health Sciences University Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: Recently, only anti-thyroid peroxidase (anti-TPO) has been suggested as an autoantibody in the diagnosis of chronic lymphocytic thyroiditis (CLT). In contrast, anti-thyroglobulin (anti-Tg) positivity has also been reported to be important. To evaluate this relationship more clearly, we planned to retrospectively investigate the autoantibody levels of the patients who underwent thyroid surgery for various reasons and those with CLT in postoperative pathology. Read More

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http://dx.doi.org/10.14744/SEMB.2017.36450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315066PMC

Complication Risk in Secondary Thyroid Surgery.

Sisli Etfal Hastan Tip Bul 2018 20;52(1):19-25. Epub 2018 Mar 20.

Health Sciences University, İstanbul Şişli Hamidiye Etfal Health Practice and Research Center, İstanbul, Turkey.

Objectives: Secondary thyroid surgery is rare, compared with primary thyroid surgery. However, secondary surgery has a greater risk of complications due to the formation of scar tissue as well as increased fragility of the tissues following the previous surgery. Several surgical techniques and strategies have been recommended to decrease the complication rate associated with secondary surgery. Read More

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http://dx.doi.org/10.14744/SEMB.2017.87609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315072PMC

Dome-and-dart T Waves and Hyperthyroidism - A Case Report.

Eur Endocrinol 2020 Apr 28;16(1):69-71. Epub 2020 Feb 28.

Department of Medicine, Internal Medicine-3, University of Padova, Padova, Italy.

We briefly describe a case of a 31-year-old man with persistent hyperthyroidism, despite medical treatment with high dose methimazole. Twelve-lead 24-hour Holter monitoring showed bifid (or dome-and-dart) T waves and echocardiography revealed mild left ventricle dilatation. Hyperthyroidism was eventually treated with total thyroidectomy, and thereafter, T waves became normal and the left ventricle returned to normal dimensions. Read More

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http://dx.doi.org/10.17925/EE.2020.16.1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308098PMC

Anticancer Drug-induced Thyroid Dysfunction.

Eur Endocrinol 2020 Apr 4;16(1):32-39. Epub 2020 Feb 4.

Bharti Hospital, Karnal, India.

Cancer immunotherapy and targeted therapy, though less toxic than conventional chemotherapy, can increase the risk of thyroid dysfunction. Immune checkpoint inhibitors render the cancer cells susceptible to immune destruction, but also predispose to autoimmune disorders like primary hypothyroidism as well as central hypothyroidism secondary to hypophysitis. Tyrosine kinase inhibitors act by blocking vascular endothelial growth factor receptors and their downstream targets. Read More

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http://dx.doi.org/10.17925/EE.2020.16.1.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308097PMC

Corticosteroid Pulse Therapy for Graves' Ophthalmopathy Reduces the Relapse Rate of Graves' Hyperthyroidism.

Front Endocrinol (Lausanne) 2020 11;11:367. Epub 2020 Jun 11.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Catania, Italy.

A course of anti-thyroid drugs (ATD) is the most common first line treatment for Graves' hyperthyroidism. However, hyperthyroidism relapse is frequent (30-70%). Due to the autoimmune nature of Graves' disease, the immunosuppressive treatment used for active Graves' orbitopathy (GO) may reduce the relapses after ATD discontinuation. Read More

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http://dx.doi.org/10.3389/fendo.2020.00367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301650PMC

Evaluation of Choroidal Thickness and Retinal Vessel Density in Patients with Inactive Graves' Orbitopathy.

Photodiagnosis Photodyn Ther 2020 Jun 24:101898. Epub 2020 Jun 24.

University of Health Sciences, Istanbul Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. Electronic address:

Background: To investigate choroidal thickness using spectral domain-optical coherence tomography and retinal vessel density with optical coherence tomography angiography in patients with inactive Graves' orbitopathy.

Methods: A total of 36 eyes of 36 patients with inactive Graves' orbitopathy (6 men and 30 women in Group 1) and 36 eyes from 36 controls (8 men and 28 women in Group 2) were recruited for this prospective case-control study. Choroidal thickness measurements were obtained using enhanced depth imaging with spectral domain-optical coherence tomography. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101898DOI Listing

Nurse practitioner students' observations of preceptor engagement in obesity management and weight bias: A mixed-methods approach.

J Am Assoc Nurse Pract 2020 Jun 23. Epub 2020 Jun 23.

College of Nursing, University of South Alabama, Mobile, Alabama.

Background: Obesity is considered a growing epidemic in the United States. Nurse practitioners (NPs) have the opportunity to serve as leaders in addressing concerns related to disease management, particularly obesity. Currently, we lack an awareness of how NP students are learning obesity management from their preceptors. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000440DOI Listing

Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves' Disease: results of a pilot study.

J Endocrinol Invest 2020 Jun 25. Epub 2020 Jun 25.

Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: The insulin-like growth factor-1 receptor (IGF-1R) is a key element in the pathogenesis of Graves' Orbitopathy (GO), but the role of IGF-1R autoantibodies (IGF-1RAbs) has not been established.

Methods: We designed a cross-sectional investigation to measure IGF-1RAbs in patients with Graves' disease (GD), with or without GO, who underwent radioiodine therapy followed by glucocorticoids (GC). Twenty-nine patients were included, 15 of which with GO. Read More

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http://dx.doi.org/10.1007/s40618-020-01341-2DOI Listing

Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves' disease.

J Endocrinol 2020 Aug;246(2):135-147

Procorde - advancecor, Martinsried, Germany.

Graves' disease is an autoimmune disorder, which is characterized by stimulatory antibodies targeting the human thyrotropin receptor (TSHR), resulting in hyperthyroidism and multiple organ damage. We systematically investigated monomeric and dimeric fusion proteins of the A subunit of TSHR for efficacy to bind to the monoclonal patient antibody M22, to interact with Graves' patient serum samples, and to impact on anti-TSHR antibody titers, hyperthyroidism, tachycardia and other in vivo read-outs in a long-term mouse model of Graves' disease induced by immunization with a recombinant adenovirus encoding TSHR A. Binding assays and functional measurements of TSHR-dependent cAMP formation showed binding of monomeric TSHR-His and dimeric TSHR-Fc to the anti-TSHR antibody M22 at low-effective concentrations (EC50 of 5. Read More

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http://dx.doi.org/10.1530/JOE-20-0061DOI Listing

Surgical management of benign thyroid disease in children.

Semin Pediatr Surg 2020 Jun 16;29(3):150922. Epub 2020 May 16.

Department of Pediatric Surgery, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Benign thyroid disease in children represents a wide spectrum of disease. While most benign thyroid disorders may be either monitored or managed medically, surgery is an important treatment, particularly for Graves' disease or large multinodular goiters. Multidisciplinary teams including specialists in pediatric endocrinology, genetics, radiology, pathology and surgery at high volume centers offer the safest and most effective management. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150922DOI Listing

Pilot early phase II study of decitabine and carboplatin in patients with advanced melanoma.

Medicine (Baltimore) 2020 Jun;99(25):e20705

Centre for Drug Repurposing and Medicines Research, School of Medicine and Public Health, University of Newcastle and Hunter Medical Research Institute.

Introduction: Resistance to targeted and immune checkpoint blockade treatment remains a major problem in patients with advanced metastatic melanoma. To overcome this problem, there needs to be a decrease in burden of disease as well as re-establishing of immune sensitivity. The aim of this early phase 2 clinical trial is to investigate a novel way of sequencing and combining decitabine and carboplatin to decrease methylation and increase DNA repair resulting in a decrease in the disease burden and to re-establish sensitivity to the immune response. Read More

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http://dx.doi.org/10.1097/MD.0000000000020705DOI Listing

"Stripe sign"- MRI characteristic of extraocular muscles in tendon sparing thyroid eye disease.

Orbit 2020 Jun 22. Epub 2020 Jun 22.

California Pacific Medical Center, The Eye Institute , San Francisco, California, USA.

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http://dx.doi.org/10.1080/01676830.2020.1782440DOI Listing

Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives.

Curr Eye Res 2020 Jun 21:1-17. Epub 2020 Jun 21.

Department of Centre of Advanced Research (CFAR), King George's Medical University (KGMU) , Lucknow, India.

Purpose: TAO is an organ specific autoimmune disease associated with thyroid, and inflammation of the orbit and periorbital tissues, which is different from systemic autoimmune diseases such as SLE. However, Grave's disease is a kind of systemic autoimmune syndrome which might involve the thyroid, the eye ball and the anterior tibial tissue. Considering the inexplicable understanding of TAO pathogenesis, the disease worsens for the patients. Read More

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http://dx.doi.org/10.1080/02713683.2020.1776331DOI Listing

Associations of Yersinia enterocolitica infection with autoimmune thyroid diseases: a systematic review and meta-analysis.

Endocr Metab Immune Disord Drug Targets 2020 Jun 21. Epub 2020 Jun 21.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Introduction: Yersinia enterocolitica infection is reportedly associated with the development of autoimmune thyroid diseases (AITD). However, evidence that such infection can lead to AITD is controversial. Thus, this study was aimed to investigate the associations of Y. Read More

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http://dx.doi.org/10.2174/1871530320666200621180515DOI Listing

Clinical diagnostic performance of a fully automated TSI immunoassay vs. that of an automated anti‑TSHR immunoassay for Graves' disease: a Chinese multicenter study.

Endocrine 2020 Jun 19. Epub 2020 Jun 19.

Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, 100730, China.

Background: Both thyroid-stimulating immunoglobulins immunoassay (TSI IA) and thyrotrophin receptor antibody immunoassay (TRAb IA) are commonly used for the diagnosis of Graves' disease (GD). The aim of the present study was to compare the clinical diagnostic performance of these two methods.

Methods: Sera were obtained from 1103 subjects presenting a variety of clinical conditions from three centers: 100 subjects with untreated GD, 200 with treated GD, 62 with autoimmune thyroid disease(AIT), 216 with other thyroid diseases (OTHER-T), 214 with non-thyroid autoimmune diseases (NTAD), 191 with other diseases (OD), and 120 healthy subjects (HS). Read More

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http://dx.doi.org/10.1007/s12020-020-02386-2DOI Listing

Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves' disease.

Arch Endocrinol Metab 2020 May-Jun;64(3):243-250

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: Intrathyroid injection of dexamethasone (IID) was used for decrease the relapse rate of hyperthyroidism in the treatment of Graves' disease (GD), but the mechanism is still unclear. We aimed to explore the effect of IID on T help (Th)1/Th2 cells and their chemokine in patients with GD.

Subjects And Methods: A total of 42 patients with GD who were euthyroidism by methimazole were randomly divided into IID group (n = 20) and control group (n = 22). Read More

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http://dx.doi.org/10.20945/2359-3997000000244DOI Listing

Racial disparities in comorbid conditions among patients undergoing thyroidectomy for Graves' disease: An ACS-NSQIP analysis.

Am J Surg 2020 May 21. Epub 2020 May 21.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, 200 Hawkins Drive, 1500 JCP, Iowa City, IA, 52242, USA. Electronic address:

Background: Studies indicate that racial disparities exist in the presentation and outcomes of patients undergoing thyroidectomy for cancer and benign disease. We examined the relationship between race, pre-operative characteristics and outcomes in patients undergoing thyroidectomy for GD.

Methods: Patients were identified from the 2013-2016 American College of Surgeons NSQIP database using ICD-9/10 codes consistent with diffuse toxic goiter. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.05.023DOI Listing

Can neutrophil/lymphocyte ratio be used as an indicator of inflammation in patients with hyperthyroidism?

J Med Biochem 2020 Jan;39(1):7-12

University of Health Science, Keçiören Health Administration and Research Center, Department of Endocrinology and Metabolism, Ankara, Turkey.

Background: In our study, we aimed to evaluate changes in the neutrophil and lymphocyte series and investigate whether the neutrophil/lymphocyte ratio (NLR) is indicative of inflammations in patients with hyperthyroidism.

Methods: A total of 161 patients were enrolled, 121 of which had hyperthyroidism (71 Graves' Disease (GD) and 50 non-Graves hyperthyroidism (NGH) patients) and 40 of which were control group members. Retrospectively, patients' neutrophil and lymphocyte counts were taken, and the NLR was calculated. Read More

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http://dx.doi.org/10.2478/jomb-2019-0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282227PMC
January 2020

Low Bone Mineral Density at Initial Diagnosis in Children and Adolescents with Graves' Disease.

J Clin Densitom 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Republic of Korea. Electronic address:

Previous studies have reported reduced bone mineral density (BMD) in patients with hyperthyroidism. We assessed the association of BMD in children and adolescents with Graves' disease (GD) after correcting for potential confounders affecting BMD such as age, sex, and pubertal status. Forty-four children and adolescents with GD and 172 age- and sex-matched healthy controls were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.jocd.2020.05.006DOI Listing

Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?

Nutrients 2020 Jun 12;12(6). Epub 2020 Jun 12.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on thyroid function. Thyroid and intestinal diseases prevalently coexist-Hashimoto's thyroiditis (HT) and Graves' disease (GD) are the most common autoimmune thyroid diseases (AITD) and often co-occur with Celiac Disease (CD) and Non-celiac wheat sensitivity (NCWS). This can be explained by the damaged intestinal barrier and the following increase of intestinal permeability, allowing antigens to pass more easily and activate the immune system or cross-react with extraintestinal tissues, respectively. Read More

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http://dx.doi.org/10.3390/nu12061769DOI Listing

Evidence of Q Fever and Rickettsial Disease in Chile.

Trop Med Infect Dis 2020 Jun 11;5(2). Epub 2020 Jun 11.

Bacteriology, Sub-Department of Infectious Diseases, Department Biomedical Laboratory, Public Health Institute of Chile, Santiago 7780050, Chile.

Q fever and rickettsial diseases occur throughout the world and appear to be emergent zoonoses in Chile. The diagnosis of these diseases is currently uncommon in Chile, as their clinical presentations are non-specific and appropriate diagnostic laboratory assays are of limited availability. During a recent outbreak of undiagnosed human atypical pneumonia, we serologically investigated a series of 357 cases from three regions of southern Chile. Read More

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http://dx.doi.org/10.3390/tropicalmed5020099DOI Listing

Preoperative plasmapheresis experience in Graves' disease patients with anti-thyroid drug-induced hepatotoxicity.

Transfus Apher Sci 2020 Jun 2:102826. Epub 2020 Jun 2.

Marmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey. Electronic address:

Hepatotoxicity is a rare but serious side effect of antithyroid drug (ATI) therapy in Graves' disease patients. Cessation of ATI drug is needed in most of the patients if liver enzymes highly elevated or in case of agranulocytosis. Permanent therapy, surgery or radioactive iodine ablation are the treatment choices to ensure euthyroidism in active Graves' disease patients. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102826DOI Listing

Ensuring ethical data access: the Sierra Leone Ebola Database (SLED) model.

Ann Epidemiol 2020 Jun 10;46:1-4. Epub 2020 Apr 10.

Columbia Mailman School of Public Health, ICAP, Sierra Leone Ebola Database (SLED) Data Team, Freetown, Sierra Leone.

Purpose: Organizations responding to the 2014-2016 Ebola epidemic in Sierra Leone collected information from multiple sources and kept it in separate databases, including distinct data systems for Ebola hot line calls, patient information collected by field surveillance officers, laboratory testing results, clinical information from Ebola treatment and isolation facilities, and burial team records.

Methods: After the conclusion of the epidemic, the Sierra Leone Ministry of Health and Sanitation and the U.S. Read More

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http://dx.doi.org/10.1016/j.annepidem.2020.04.001DOI Listing

Antithyroid drugs in Graves' hyperthyroidism: differences between "block and replace" and "titration" regimes in frequency of euthyroidism and Graves' orbitopathy during treatment.

J Endocrinol Invest 2020 Jun 10. Epub 2020 Jun 10.

Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

Purpose: Whereas antithyroid drugs (ATD) are the preferred treatment modality for Graves' hyperthyroidism (GH), there is still controversy about the optimal regimen for delivering ATD. To evaluate whether 'Block and Replace' (B + R) and 'Titration' (T) regimes are equivalent in terms of frequency of euthyroidism and Graves' Orbitopathy (GO) during ATD therapy.

Methods: A prospective multicentre observational cohort study of 344 patients with GH but no GO at baseline. Read More

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http://dx.doi.org/10.1007/s40618-020-01320-7DOI Listing

MASSIVE THYMIC HYPERPLASIA SECONDARY TO GRAVES DISEASE.

AACE Clin Case Rep 2020 May-Jun;6(3):e144-e146. Epub 2020 May 8.

Objective: Graves disease (GD) has a well-known association with thymic hyperplasia, which is seen histo-logically in up to 38% of patients with GD. However, there have only been approximately 100 documented cases of Graves-associated massive thymic hyperplasia. Potential mechanisms of thymic pathology are reviewed. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282277PMC

Arterial Stiffness and Blood Pressure in Patients Newly Diagnosed with Graves' Disease Compared with Euthyroid Controls.

Eur Thyroid J 2020 May 14;9(3):148-156. Epub 2020 Feb 14.

Medical Department, Silkeborg Regional Hospital, Silkeborg, Denmark.

Introduction And Objective: The excess cardiovascular morbidity and mortality in hyperthyroidism and Graves' disease (GD) is inadequately understood. We aimed to elucidate whether well-established cardiovascular risk factors such as arterial stiffness in terms of pulse wave velocity (PWV) and blood pressure differ in GD and controls.

Methods: This was a cross-sectional study comparing 55 hyperthyroid patients with newly diagnosed GD and 55 euthyroid, population-based controls matched for age, sex and menopausal status. Read More

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http://dx.doi.org/10.1159/000505873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265727PMC

TRAb elevations occurred even in the third trimester; a case of a mother of a child with neonatal thyroid dysfunction, who received radioactive iodine therapy for Graves' disease.

Endocr J 2020 Jun 10. Epub 2020 Jun 10.

Department of Surgery, Ito Hospital, Tokyo 150-8308, Japan.

Activity of Graves' disease (GD) is known to improve during gestation, as values of thyrotropin (TSH) receptor antibody (TRAb) also improve. However, the risk of neonatal hyperthyroidism increases when maternal TRAb values are high in the second to third trimester. A 29-year-old woman who had undergone radioactive iodine (RAI) therapy for GD 10 years earlier visited our hospital at 17 weeks of gestation, showing subclinical hypothyroidism and a positive TRAb value of 2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ20-0039DOI Listing

Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis.

Clin Sci (Lond) 2020 Jun;134(12):1521-1535

Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong 250021, China.

Background Previous studies have shown that the gut microbiome is associated with thyroid diseases, including Graves' disease, Hashimoto's disease, thyroid nodules, and thyroid cancer. However, the association between intestinal flora and primary hypothyroidism remains elusive. We aimed to characterize gut microbiome in primary hypothyroidism patients. Read More

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http://dx.doi.org/10.1042/CS20200475DOI Listing
June 2020
5.598 Impact Factor

Association of MICA gene polymorphisms with thionamide-induced agranulocytosis.

J Endocrinol Invest 2020 Jun 9. Epub 2020 Jun 9.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Background: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 10/L after ATD administration. Read More

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http://dx.doi.org/10.1007/s40618-020-01319-0DOI Listing

Work disability in rheumatic diseases: Baseline results from an inception cohort.

Int J Rheum Dis 2020 Jun 8. Epub 2020 Jun 8.

Department of Rheumatology and Immunology, Singapore General Hospital, Singapore City, Singapore.

Aim: We aimed to characterize work disability in patients with newly diagnosed rheumatic diseases and compare work characteristics between patients with rheumatic diseases and controls without rheumatic diseases at diagnosis.

Methods: Patients with inflammatory arthritis (IA) and osteoarthritis (OA), surrogates for autoimmune and non-autoimmune rheumatic diseases, respectively, and controls of working age were surveyed at diagnosis. Patients with rheumatic diseases who were employed before symptom onset were characterized as having work disability if they reported reduced work ability and productivity while remaining in the same job as before symptom onset, changed to a less demanding job or stopped working/retired. Read More

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http://dx.doi.org/10.1111/1756-185X.13864DOI Listing
June 2020
1.771 Impact Factor

Management of Thyroid Eye Disease-Related Strabismus.

J Curr Ophthalmol 2020 Jan-Mar;32(1):1-13. Epub 2020 Mar 23.

Eye Research Center, Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To review various treatment methods in thyroid eye disease (TED) related strabismus.

Methods: We searched in PubMed and Google Scholar and Ovid MEDLINE for keywords including TED-related strabismus, strabismus in thyroid-associated ophthalmopathy, Graves ophthalmopathy related strabismus or squint, and restrictive strabismus. Two expert strabismus specialists selected and evaluated the English articles that were related to our paper and had been published since 2000. Read More

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http://dx.doi.org/10.1016/j.joco.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265261PMC

Changes in ocular biomechanics after treatment for active Graves' orbitopathy.

J Endocrinol Invest 2020 Jun 7. Epub 2020 Jun 7.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.

Purpose: To evaluate the changes in ocular biomechanical properties in active moderate-to-severe Graves' orbitopathy (GO) after intravenous glucocorticoids (IVGCs), and to clarify correlations between clinical findings and ocular biomechanical properties.

Methods: A prospective study. A total of 20 consecutive GO patients and 20 age- and sex-matched healthy control subjects were included. Read More

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http://dx.doi.org/10.1007/s40618-020-01322-5DOI Listing

Temporal, Sexual, and Geographic Distributions of the Coexistence of Ulcerative Colitis and Graves Disease.

Authors:
Xiao Xian Qian

Inflamm Bowel Dis 2020 Jun 8. Epub 2020 Jun 8.

Division of Gastroenterology and Hepatology, Minhang Hospital, Fudan University, China.

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http://dx.doi.org/10.1093/ibd/izaa126DOI Listing

Severe Acute Hepatitis E in a Woman with an Autoimmune Background.

Acta Med Port 2020 Jun 31;33(6):425-428. Epub 2020 May 31.

Epidemiology Research Unit. Instituto de Saúde Pública. Universidade do Porto. Porto. Instituto de Ciências Biomédicas de Abel Salazar. Universidade do Porto. Porto. Portugal.

Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis E are seldom observed among women, younger men and children but are particularly seen in middle-aged/elderly men. We report a case of severe acute hepatitis E caused by genotype 3 in an immunocompetent 40-year-old woman that required prolonged hospitalization. Read More

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http://dx.doi.org/10.20344/amp.10429DOI Listing

An intronic HCP5 variant is associated with age of onset and susceptibility to Graves' disease in UK and Polish cohorts.

J Clin Endocrinol Metab 2020 Jun 5. Epub 2020 Jun 5.

Translational and Clinical Research Institute, Newcastle University, Newcastle-Upon-Tyne, UK.

Context: The genetic background of young onset Graves' disease (GD) remains largely unknown. An intronic variant in HLA complex P5 (HCP5) has previously been associated with GD susceptibility and age of onset in a cohort of Polish patients.

Objective: We aimed to investigate the association of the HCP5 variant rs3094228 with GD susceptibility and age of onset in a UK cohort and conduct a meta-analysis of UK and Polish data. Read More

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http://dx.doi.org/10.1210/clinem/dgaa347DOI Listing

Onset of Marine-Lenhart syndrome and Graves' ophthalmopathy in a female patient treated with alemtuzumab for multiple sclerosis.

Hormones (Athens) 2020 Jun 5. Epub 2020 Jun 5.

Department of Clinical and Experimental Medicine, Endocrinology Unit, University of Catania, Garibaldi-Nesima Hospital, Via Palermo 636, 95122, Catania, Italy.

Background: Immune checkpoint blockade therapy may lead to thyroid dysfunction in 3-7% of treated patients. Alemtuzumab is a CD52 inhibitor leading to thyroid dysfunction in approximately 40% of patients. A female patient was affected by multiple sclerosis (MS) and subclinical hyperthyroidism due to an autonomously functioning thyroid nodule (AFTN). Read More

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http://dx.doi.org/10.1007/s42000-020-00215-9DOI Listing

Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors.

J Endocrinol Invest 2020 Jun 4. Epub 2020 Jun 4.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Dopaminergic system is interconnected with the hypothalamic-pituitary-thyroid axis. Dopamine (DA) upregulates thyrotropin releasing hormone (TRH) while downregulating thyroid stimulating hormone (TSH) and thyroid hormones. Read More

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http://dx.doi.org/10.1007/s40618-020-01314-5DOI Listing