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    Thyroid Ultrasonography in Differentiation between Graves' Disease and Hashimoto's Thyroiditis.
    J Biomed Phys Eng 2017 Mar 1;7(1):21-26. Epub 2017 Mar 1.
    Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Objective: Graves' disease and Hashimoto's thyroiditis are the most common causes of hyper and hypothyroidism, respectively. Differentiation of these 2 diseases, if the patient is euthyroid, may sometimes be extremely difficult on the basis of clinical and laboratory findings. The purpose of this study was to determine the sensitivity and specificity of gray scale sonography in differentiation of Graves' disease from Hashimoto's thyroiditis. Read More

    [Student abuse and Graves-basedow's disease: about a case].
    Pan Afr Med J 2017 12;26:15. Epub 2017 Jan 12.
    Service d'Endocrinologie du Centre Hospitalier Universitaire de Libreville, Libreville, Gabon.
    Graves-basedow's disease is an autoimmune thyreopathy which represents the most common cause of hyperthyroidism in both adults and children. This disease would be related to a genetic predisposition influenced by environmental triggers, including stress. This study aims to present a case of Graves' disease in children whose unusual trigger would be student abuse, a broad challenge with multiple implications. Read More

    Iodine-131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease.
    Exp Ther Med 2017 Mar 16;13(3):1155-1159. Epub 2017 Jan 16.
    Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China.
    The aim of the present study was to evaluate the serum levels of interleukin-6 (IL-6), CXC chemokine ligand-10 (CXCL-10) and intercellular adhesion molecule-l (ICAM-1) in patients with Graves' disease (GD) following iodine-131 ((131)I) therapy. A total of 30 patients with GD participated in the present study. Serum cytokine levels were measured with ELISA, and correlation analyses were performed. Read More

    Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.
    Endocr Metab Immune Disord Drug Targets 2017 Apr 23. Epub 2017 Apr 23.
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University; Institute of Endocrinology, The Liaoning Provincial Key Laboratory of Endocrine Diseases, China Medical University, 155 Nanjing Bei Street, Liaoning. China.
    Objective: Our objectives were to investigate the therapeutic effect of halofuginone (HF) in the treatment of autoimmune thyroid diseases (AITDs) and explore its underlying mechanism of action.

    Methods: The Graves' disease (GD) model was generated by immunizing female BALB/c mice with adenovirus expressing the TSH receptor A subunit (Ad-TSHR289). The Ad-TSHRA+HF and Ad-TSHRA+DMSO groups were injected intraperitoneally with HF or the vehicle control (DMSO), respectively. Read More

    Prevalence and clinical relevance of tsh receptor blocking antibodies in autoimmune thyroid disease.
    Clin Exp Immunol 2017 Apr 25. Epub 2017 Apr 25.
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
    Objective: The prevalence and clinical relevance of TSH-receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated.

    Methods: Serum TBAb were measured with a reporter gene bioassay using chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). Read More

    The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases.
    Front Immunol 2017 7;8:396. Epub 2017 Apr 7.
    Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
    Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves' disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Read More

    Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachment.
    Turk Pediatri Ars 2017 Mar 1;52(1):1-9. Epub 2017 Mar 1.
    Department of Pediatrics, Division of Neonatology and Pediatric Endocrinology, Erciyes University School of Medicine, Kayseri, Turkey.
    Fetal and neonatal hyperthyroidism may occur in mothers with Graves' disease. Fetal thyrotoxicosis manifestation is observed with the transition of TSH receptor stimulating antibodies to the fetus from the 17th-20th weeks of pregnancy and with the fetal TSH receptors becoming responsive after 20 weeks. The diagnosis is confirmed by fetal tachycardia, goiter and bone age advancement in pregnancy and maternal treatment is conducted in accordance. Read More

    Endocr Pract 2017 Apr;23(4):466-470
    Objective: Technetium thyroid uptake (TTU) is not inhibited by antithyroid drugs (ATD) and reflects the degree of thyroid stimulation. We intended to predict the relapse rate from hyperthyroidism based on TTU measurement.

    Methods: Out of 44 initially enrolled subjects, 38 patients aged 41. Read More

    Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis.
    Chem Biol Interact 2017 Apr 18. Epub 2017 Apr 18.
    Laboratory LR11ES45, Research Group "Biotechnology and Pathology", National School of Engineers, Univeristy of Sfax, Tunisia; Service of Nuclear Medicine, CHU Habib Bourguiba, Sfax, Tunisia.
    The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Read More

    Graves' orbitopathy as a rare disease in Europe: a European Group on Graves' Orbitopathy (EUGOGO) position statement.
    Orphanet J Rare Dis 2017 Apr 20;12(1):72. Epub 2017 Apr 20.
    Academic Medical Center, 22660 1100 DD, Amsterdam, Netherlands.
    Background: Graves' orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this disease are sparse. Several clinical variants of GO exist, including euthyroid GO, recently listed as a rare disease in Europe (ORPHA466682). Read More

    Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease.
    Front Endocrinol (Lausanne) 2017 3;8:57. Epub 2017 Apr 3.
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
    Production of thyroid-stimulating hormone receptor (TSHR) antibodies represents the hallmark of Graves' disease (GD) pathogenesis. Thus, for more than two decades the TSHR gene has been at the center of studies intended to elucidate its contribution to disease pathology. The advent of genome-wide association technology allowed to establish a strong association of the TSHR gene with GD. Read More

    Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.
    PLoS One 2017 18;12(4):e0175274. Epub 2017 Apr 18.
    Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
    Background: Graves' orbitopathy (GO) is an autoimmune inflammatory ocular complication and one of the most frequent manifestations of Graves' disease (GD). Clinical judgment of GO is subjective sometimes leading to clinical and therapeutic challenges. Better tools to diagnose this severe complication are warranted. Read More

    25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient.
    Endocr J 2017 04 11. Epub 2017 Apr 11.
    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China.
    Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department. Read More

    Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review.
    Allergy 2017 Apr 13. Epub 2017 Apr 13.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergy, Berlin, Germany.
    Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Read More

    Thyroid-associated Ophthalmopathy.
    Turk J Ophthalmol 2017 Apr 1;47(2):94-105. Epub 2017 Apr 1.
    Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.
    Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves' disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood. Autoimmunity against putative antigens shared by the thyroid and the orbit plays a role in the pathogenesis of disease. Read More

    Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.
    Qual Life Res 2017 Apr 9. Epub 2017 Apr 9.
    DeltaQuest Foundation Inc., 31 Mitchell Road, Concord, MA, 01742, USA.
    Purpose: To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.

    Methods: Fifty-two youth with MS (16.03 ± 2. Read More

    Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative.
    Rev Esp Med Nucl Imagen Mol 2017 Apr 6. Epub 2017 Apr 6.
    Unidad de Gestión Clínica de Medicina Nuclear, Hospital Regional Universitario de Málaga, Málaga, España.
    The case is presented of a 3 year-old girl with mitochondrial disease (subacute necrotizing encephalomyelopathy of Leigh syndrome), v-stage chronic kidney disease of a diffuse mesangial sclerosis, as well as developmental disorders, and diagnosed with hyperthyroidism Graves-Basedow disease. Six weeks after starting the treatment with neo-carbimazole, the patient reported a serious case of agranulocytosis. This led to stopping the anti-thyroid drugs, and was treated successfully with (131)I ablation therapy. Read More

    ANNALS EXPRESS: Stimulating TSH receptor autoantibodies immunoassay: analytical evaluation and clinical performance in Graves' Disease.
    Ann Clin Biochem 2017 Jan 1:4563217700655. Epub 2017 Jan 1.
    Catholic University School of Medicine.
    Background: Thyroid stimulating hormone (TSH) receptor (TSHR) autoantibodies (TRAbs) are a heterogeneous group of antibodies (Abs) with different functionality. Among all TRAbs only the stimulating one (S-TRAbs) are considered the pathogenetic marker of Graves' Disease (GD). To date, the methods available for TRAbs testing are based on immunoassays (IMAs) which detect total serum TRAbs or bioassays which are not suitable in clinical practice, even though they discern Abs functionality. Read More

    Geriatric patients are predisposed to strabismus following thyroid-related orbital decompression surgery: A multivariate analysis.
    Orbit 2017 Apr 14;36(2):95-101. Epub 2017 Feb 14.
    a Department of Ophthalmology and Visual Sciences , W. K. Kellogg Eye Center, University of Michigan , Ann Arbor , Michigan , USA.
    Geriatric patients (age ≥ 65) are prone to complications after surgery and are at risk for severe thyroid eye disease (TED). In this study, we aim to identify preoperative demographic and TED patterns associated with geriatric patients who underwent decompression surgery, to examine the effect of age on postoperative strabismus rates, and to identify factors that may contribute to postoperative strabismus in the geriatric subgroup. We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center, University of Michigan, between 1999 and 2014. Read More

    (99)Tc(m)-octreotide scintigraphy and serum eye muscle antibodies in evaluation of active thyroid-associated ophthalmopathy.
    Eye (Lond) 2017 Apr 7. Epub 2017 Apr 7.
    The Key Laboratory of National Ministry of Health for Forensic Science, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
    PurposeAs an autoimmune inflammatory disorder, active thyroid-associated ophthalmopathy (TAO) is managed optimally by immunosuppression. In this study, we aimed to evaluate octreotide scintigraphy and the level of serum extraocular muscle antibodies in TAO activity.Patients and methodsThis prospective study comprised 304 patients with active TAO (the clinical activity score; CAS≥3), 73 with inactive TAO (CAS<3), 128 with Graves' disease (GD) without ophthalmopathy, and 100 healthy subjects. Read More

    Management of childhood thyroid nodules: Surgical and endocrinological experience in more than one hundred cases.
    J Clin Res Pediatr Endocrinol 2017 Apr 7. Epub 2017 Apr 7.
    Objective: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children.

    Methods: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Read More

    [An rare complication of scarlet fever : invasive group A streptococcal infection with streptococcal toxic shock syndrome].
    Rev Med Liege 2017 Mar;72(3):132-137
    Service de Pédiatrie, CHU de Liège, Site NDB, Liège, Belgique.
    Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are particulary challenging because of their rapid progression and the lack of predisposing factors in most cases. Prompt diagnosis and treatment are mandatory to reduce the mortality associated with these severe diseases. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Arguments for the prolonged use of antithyroid drugs in children with Graves' disease.
    Eur J Endocrinol 2017 Apr 5. Epub 2017 Apr 5.
    J Carel, Paediatric endocrinology, Hôpital Robert Debre, Paris, France.
    Graves' disease is an autoimmune disorder. It is the major cause of hyperthyroidism but is rare in children. Patients are initially managed with antithyroid drugs (ATD), in the form of methimazole/carbimazole. Read More

    Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.
    PLoS One 2017 5;12(4):e0174863. Epub 2017 Apr 5.
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape. Understanding the molecular characteristics of pancreatic ductal adenocarcinoma will facilitate the identification of potential therapeutic strategies. Read More

    Delayed TSH recovery after dose adjustment during TSH-suppressive levothyroxine therapy of thyroid cancer.
    Clin Endocrinol (Oxf) 2017 Apr 4. Epub 2017 Apr 4.
    Division of Endocrinology & Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul.
    Background: Delayed thyroid-stimulating hormone (TSH) recovery during treatment of Graves' disease is caused by long-term excessive thyroid hormone, which results in down-regulation of pituitary thyrotropes. However, it is unknown whether delayed TSH recovery exists after levothyroxine (LT4) dose reduction in differentiated thyroid cancer (DTC) patients after long-term TSH suppression.

    Methods: We retrospectively reviewed 97 DTC patients with LT4 dose reduction after long-term TSH suppression. Read More

    Severe polyarthralgia, high-grade fever, diffuse maculopapular rash on trunk and extremities · Dx?
    J Fam Pract 2017 Apr;66(4):E7-E9
    Ole Health, Fairfield, CA, USA.
    The patient was nauseous, and had been experiencing headaches, generalized weakness, and fatigue. Her physical exam revealed a maculopapular rash on her trunk and upper extremities. She had tenderness and pain, as well as decreased range of motion in her ankles, knees, and wrists. Read More

    Environmental Issues in Thyroid Diseases.
    Front Endocrinol (Lausanne) 2017 20;8:50. Epub 2017 Mar 20.
    Department of Clinical and Experimental Medicine, University of Messina School of Medicine, Messina, Italy; Master Program of Childhood, Adolescence and Women's Endocrine Health, University of Messina School of Medicine, Messina, Italy; Interdepartmental Program of Molecular & Clinical Endocrinology, and Women's Endocrine Health, University Hospital, Policlinico G. Martino, Messina, Italy.
    Environmental factors are determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subjects. Increased iodine intake, selenium, and vitamin D deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing AITD. Cigarette smoking is associated with Graves' disease and Graves' ophthalmopathy, while it decreases the risk of hypothyroidism and thyroid autoimmunity. Read More

    Cyclic peptides for effective treatment in a long-term model of Graves´ disease and orbitopathy in female mice.
    Endocrinology 2017 Mar 29. Epub 2017 Mar 29.
    Procorde-advanceCOR, Fraunhofer Str. 9a, D 82152 Martinsried, Germany.
    A model for human Graves´ disease in mice was used to compare several novel treatment approaches. The mice received regular adenoviral (Ad) thyroid-stimulating receptor (TSHR) A subunit immunisations (4-weekly injections). Generation of anti-TSHR antibodies, enlarged thyroid sizes (goiter), elevated serum thyroxin levels, retro-orbital fibrosis and cardiac involvement (tachycardia and hypertrophy) were consistently observed during 9 months. Read More

    Peripartum dynamics of Coxiella burnetii infections in intensively managed dairy goats associated with a Q fever outbreak in Australia.
    Prev Vet Med 2017 Apr 20;139(Pt A):58-66. Epub 2017 Feb 20.
    Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Australia.
    Coxiella burnetii may cause reproduction disorders in pregnant animals but subclinical infection in other animals. Unrecognised disease may delay implementation of control interventions, resulting in transmission of infection to other livestock and to humans. Seroreactivity to C. Read More

    Life-threatening endocrine emergencies during pregnancy - management and therapeutic features.
    Gynecol Endocrinol 2017 Mar 31:1-5. Epub 2017 Mar 31.
    b Department of Medicine II , University of Lübeck , Lübeck , Germany.
    Endocrine emergencies during pregnancy may be life-threatening events for both mother and fetus. Besides pregnancy-associated endocrine disorders, several pre-existing endocrinopathies such as type-1 diabetes and Grave's disease or adrenal failure may acutely deteriorate during pregnancy. Since "classical" signs are often modified by pregnancy, early diagnosis and management may be hampered. Read More

    Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.
    Neurology 2017 Apr 29;88(17):1623-1629. Epub 2017 Mar 29.
    From the Division of Epidemiology, School of Public Health (M.A.G., X.S., E.X., H.Q., D.Q., C.M., L.F.B.), and Computational Biology Graduate Group (B.R.), University of California, Berkeley; Department of Clinical Neuroscience and Center for Molecular Medicine (P.S.), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Neurology (J.S.G., E.W.) and Regional Pediatric MS Center, Neurology (J.H., S.C.), University of California, San Francisco; Partners Pediatric Multiple Sclerosis Center (T.C.), Massachusetts General Hospital for Children, Boston; Division of Neurology (A.W.), Children's Hospital of Philadelphia, PA; Blue Bird Circle Multiple Sclerosis Center (T.L.), Baylor College of Medicine, Houston, TX; Children's Hospital Colorado (T.S.), University of Colorado, Denver; Lourie Center for Pediatric Multiple Sclerosis (A.B., L.K.), Stony Brook Children's Hospital, NY; Department of Neurology (B.G.), University of Texas Southwestern, Dallas; Pediatric Multiple Sclerosis Center (B.W.-G.), Jacobs Neurological Institute, SUNY Buffalo, NY; Pediatric MS Center at Loma Linda University Children's Hospital (G.A.), CA; Mayo Clinic's Pediatric Multiple Sclerosis Center (J.M.T., M.R.), Rochester, MN; University of Alabama Center for Pediatric-onset Demyelinating Disease (J.N., Y.H.), Children's Hospital of Alabama, Birmingham; Department of Pediatric Neurology (J.R.), Northwestern Feinberg School of Medicine, Chicago, IL; Primary Children's Hospital (M.C.), University of Utah, Salt Lake City; Boston Children's Hospital (M.G., L.B.), MA; Pediatric-onset Demyelinating Diseases and Autoimmune Encephalitis Center (S.M.), St. Louis Children's Hospital, Washington University School of Medicine, MO; Children's National Medical Center (I.K.), Washington, DC; Departments of Neurology (J.R.) and Pediatrics (S.R., T.C.C.), University of Utah School of Medicine, Salt Lake City; Kaiser Permanente Division of Research (L.S., C.S., L.F.B.), Oakland, CA; Institute of Environmental Medicine (J.H., M.B., A.H., T.O., I.K., L.A.), Karolinska Institutet; Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Stockholm, Sweden; and Research Program on Genes, Environment and Health (C.S.), Kaiser Permanente, Oakland, CA.
    Objective: To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).

    Methods: We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated effect of each risk variant. A BMI GRS was also created that incorporates the cumulative effect of 97 variants associated with BMI. Read More

    [A clinical analysis of 123 cases of primary empty sella].
    Zhonghua Nei Ke Za Zhi 2017 Apr;56(4):268-272
    Department of Endocrinology and Metabolism, General Hospital of Tianjin Medical University, Tianjin 300052, China.
    Objective: This study was conducted to analyze the clinical characteristics and pituitary function of patients with primary empty sella (PES). Methods: The clinical data from 123 hospitalized adult patients with PES from January 2010 to May 2016 were retrospectively studied. Results: (1) The average age of the 123 (male 43, female 80) PES patients was (59. Read More

    Pretibial Myxedema Masquerading as a Venous Leg Ulcer.
    Wounds 2017 Mar;29(3):77-79
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.
    The authors report a case of pretibial myxedema (PTM) masquerading as a venous leg ulcer to alert wound care clinicians to this diagnostic possibility. Pretibial myxedema is a localized form of mucin cutaneous deposition characterized by indurated plaques most commonly on anterior legs. It is more likely to present in patients with Graves' disease, but it can be found in euthyroid patients as well. Read More

    Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer: A Randomized Clinical Trial.
    JAMA 2017 03;317(12):1224-1233
    Queensland Centre for Gynaecological Cancer, University of Queensland, Herston, Australia8School of Medicine, University of Queensland, Herston, Australia.
    Importance: Standard treatment for endometrial cancer involves removal of the uterus, tubes, ovaries, and lymph nodes. Few randomized trials have compared disease-free survival outcomes for surgical approaches.

    Objective: To investigate whether total laparoscopic hysterectomy (TLH) is equivalent to total abdominal hysterectomy (TAH) in women with treatment-naive endometrial cancer. Read More

    Atypical Complications of Graves' Disease: A Case Report and Literature Review.
    Case Rep Endocrinol 2017 28;2017:6087135. Epub 2017 Feb 28.
    Endocrine Department, Hamad Medical Corporation, Doha, P.O. Box 3050, Qatar.
    Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. Read More

    Influenza Vaccination for Secondary Prevention of Cardiovascular Events: A Systematic Review.
    Can J Hosp Pharm 2017 Jan-Feb;70(1):27-34. Epub 2017 Feb 28.
    , BSc, BSc(Pharm), PharmD, ACPR, is with the Chilliwack General Hospital, Lower Mainland Pharmacy Services, Chilliwack, British Columbia, and the Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia.
    Background: Influenza is a common respiratory infection that may cause complications, including cardiovascular events. Influenza illness has been shown to double the risk of myocardial infarction, with the highest risk among patients with established cardiovascular disease. Vaccination against influenza has been associated with reductions in myocardial infarction, cerebrovascular disease, and death. Read More

    Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease.
    Viral Immunol 2017 Apr 23;30(3):240-249. Epub 2017 Mar 23.
    1 Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University , Yonago, Japan .
    Graves' disease is an autoimmune disease that results in and is the most common cause of hyperthyroidism, and the reactivation of persisting Epstein-Barr virus (EBV) in B lymphocytes induces the differentiation of host B cells into plasma cells. We previously reported that some EBV-infected B cells had thyrotropin receptor antibodies (TRAbs) as surface immunoglobulins (Igs), and EBV reactivation induced these TRAb+EBV+ cells to produce TRAbs. EBV reactivation induces Ig production from host B cells. Read More

    Electroconvulsive Therapy Use in Youth in the Province of Quebec.
    J Can Acad Child Adolesc Psychiatry 2017 1;26(1):4-11. Epub 2017 Mar 1.
    Institut Universitaire en Santé Mentale de Québec, Quebec City, Quebec.
    Objectives: Electroconvulsive therapy's (ECT) safety and tolerability is well-established in the treatment of severe psychiatric disorders in adults, but has been less studied in youth. The aim of the present study was to describe the use of ECT in youth in Quebec City and obtain Child and Adolescent Psychiatrists' (CAP) perceptions in the province of Quebec.

    Methods: The authors reviewed charts of minors who received ECT treatment in the Quebec City metropolitan area between 1995 and 2014 (part 1). Read More

    Graves' Ophthalmopathy in a Paediatric Population.
    Klin Monbl Augenheilkd 2017 Mar 22. Epub 2017 Mar 22.
    Oculoplastic surgery unit, Jules Gonin Eye Hospital, University of Lausanne, Switzerland.
    Background Graves' disease is an autoimmune disorder leading to hyperthyroidism. It is often associated with ophthalmic manifestations. Graves' disease is reported to be rare in the paediatric population. Read More

    Anetoderma before development of antiphospholipid antibodies: delayed development and monitoring of antiphospholipid antibodies in an SLE patient presenting with anetoderma.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Harvard Medical School, Boston, MA, USA. fandi_xia@
    Introduction: Anetoderma is an elastolytic skindisorder that has been associated with the presenceof antiphospholipid antibodies (aPL). Patients withantiphospholipid antibody-positive anetoderma havebeen reported to develop symptoms of Graves disease,antiphospholipid syndrome, and other autoimmuneconditions. The temporal relationship, however,between anetoderma onset and the emergence ofaPL remains unclear, a clarification of which may haveimplications for the screening and monitoring ofpatients with anetoderma. Read More

    Rescue pre-operative treatment with Lugol's solution in uncontrolled Graves' disease.
    Endocr Connect 2017 May 21;6(4):200-205. Epub 2017 Mar 21.
    Department of EndocrinologyMetabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
    Background: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium iodide to induce euthyroidism before surgery could be advocated, but this has rarely been reported. Read More

    Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter, Randomized, Controlled Trial (VANCO Study).
    J Orthop Trauma 2017 Apr;31 Suppl 1:S18-S24
    *Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD; †Division of Infectious Diseases, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, MD; ‡Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; §U.S. Army, Uniformed Services University of the Health Sciences; San Antonio Military Medical Center, Infectious Disease Service, San Antonio, TX; ‖Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; ¶Department of Orthopaedic Surgery, McGovern Medical School at UTHealth Houston, Houston, TX; and **Carolinas Medical Center, Department of Orthopaedic Surgery, Charlotte, NC.
    A number of clinical studies in the spine literature suggest that the use of local vancomycin powder may substantially reduce surgical site infections (SSIs). These studies are primarily retrospective and observational and few focus on orthopaedic trauma patients. This study is a phase III, prospective, randomized, clinical trial to assess the efficacy of locally administered vancomycin powder in the prevention of SSI after fracture surgery. Read More

    Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage: Correlation With Subsequent Postclosure Deep Wound Infection (Bioburden Study).
    J Orthop Trauma 2017 Apr;31 Suppl 1:S3-S9
    *Orthopaedic Trauma Service, Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC; †U.S. Army, Uniformed Services University of the Health Sciences, San Antonio Military Medical Center, Infectious Disease Service, San Antonio, TX; ‡Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, Baltimore, MD; §Harborview Medical Center, University of Washington, Department of Orthopaedics and Sports Medicine, Seattle, WA; ‖R Adams Cowley Shock Trauma Center, Department of Orthopaedics, Baltimore, MD; ¶Johns Hopkins Bloomberg School of Public Health, Department of Biostatistics, Baltimore, MD; **Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, San Antonio, TX; and ††University of St. Augustine for Health Sciences, Occupational Therapy Program, Austin, TX.
    Infection remains the most common and significant complication after high-energy fractures. The Bioburden Study is a multicenter, prospective, observational cohort study of wound bacterial bioburden and antibiotic care in severe open lower extremity fractures. The aims of this study are to (1) characterize the contemporary extremity wound "bioburden" at the time of definitive wound closure; (2) determine the concordance between polymerase chain reaction results and hospital microbiology; (3) determine, among those who develop deep infections, the concordance between the pathogens at wound closure and at deep infection; and (4) compare the probability of deep infection between those who did and did not receive an appropriate course of antibiotics based on bioburden at the time of wound closure. Read More

    Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status.
    Microbiome 2017 Mar 20;5(1):34. Epub 2017 Mar 20.
    Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Background: Periodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. Read More

    Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population.
    J Neurol Sci 2017 Apr 20;375:371-375. Epub 2017 Feb 20.
    State University of New York, Neurology, United States.
    Background: Multiple sclerosis (MS) and allergies are both considered to be related to imbalanced Th1 and Th2 immune responses. Previous studies evaluating the relationship between MS and allergies provide conflicting results.

    Objective: To assess allergies and asthma as risk factors for MS and as predictors of MS relapses in a pediatric cohort. Read More

    Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.
    PLoS One 2017 20;12(3):e0174260. Epub 2017 Mar 20.
    Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
    Background: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. Read More

    [Serratia infections, should we think about primary immunodeficiencies?]
    Arch Argent Pediatr 2017 Apr;115(2):e108-e111
    Hospital Infantil Miguel Servet, Zaragoza, España.
    Chronic granulomatous disease (CGD) is a primary immunodeficiency with an incidence of 1/200,000-250,000 live births. CGD affects mainly male patients, most of the mutations being X-linked, and autosomal recessive forms occur more frequently in communities with greater numbers of consanguineous marriages. CGD is characterized by sensitivity to recurrent and severe bacterial and fungal infections, with formation of granulomas due to the inability of phagocytes to generate reactive oxygen compounds, necessary for the intracellular death of phagocytic microorganisms. Read More

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