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    The Influence of Juvenile Graves' Ophthalmopathy on Graves' Disease Course.
    J Ophthalmol 2017 31;2017:4853905. Epub 2017 Oct 31.
    Eye Clinic of Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Purpose: To investigate juvenile Graves' ophthalmopathy (GO) signs and compare Graves' disease (GD) course in patients with or without GO.

    Patients And Methods: There were analyzed data (visual acuity, proptosis, palpebral fissure measurements, clinical activity score (CAS), and the course of GD) of 67 children who have been newly diagnosed with GD. 26. Read More

    Pleurodesis: a comparison of two sclerosing agents for pleural effusions in Mozambique.
    J Thorac Dis 2017 Sep;9(9):3132-3137
    Department of Pulmonology, Maputo Central Hospital, Maputo, Mozambique.
    Background: Pleural effusions constitute one of the most frequent pathologies encountered in the pulmonary service of Maputo Central Hospital (MCH) in Mozambique. Bleomycin and talc are commonly used for pleurodesis, but cost prohibitive, therefore we aimed to retrospectively compare the efficacy and safety of sodium hydroxide (NaOH) with bleomycin for pleurodesis.

    Methods: Case records of pleurodesis using bleomycin and NaOH from 2002 to 2013 were reviewed. Read More

    Osteocytes Play an Important Role in Experimental Periodontitis in Healthy and Diabetic Mice Through Expression of RANKL.
    J Clin Periodontol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Aim: Periodontitis results from bacteria induced inflammation. A key cytokine, RANKL is produced by a number of cell types. The cellular source of RANKL critical for periodontitis has not been established. Read More

    Regression of Ophthalmopathic Exophthalmos in Graves' Disease After Total Thyroidectomy: a Prospective Study of a Surgical Series.
    Indian J Surg 2017 Dec 22;79(6):521-526. Epub 2016 Jun 22.
    Endocare Hospital, Vijayawada, 520002 India.
    Autoimmune ophthalmopathy is one of the salient clinical features associated with Graves' disease. Exophthalmos is one of the commonest manifestations of Graves' associated ophthalmopathy. It is reported to regress after thyroidectomy favourably compared to radioiodine or antithyroid drug therapy. Read More

    Genome-Wide Association Study of Male Sexual Orientation.
    Sci Rep 2017 Dec 7;7(1):16950. Epub 2017 Dec 7.
    Department of Human Genetics, University of Miami, Miami, Florida, 33136, United States of America.
    Family and twin studies suggest that genes play a role in male sexual orientation. We conducted a genome-wide association study (GWAS) of male sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 heterosexual men using Affymetrix single nucleotide polymorphism (SNP) arrays. We identified several SNPs with p < 10-5, including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7. Read More

    Coexistence of Primary Hyperaldosteronism and Graves' Disease, a Rare Combination of Endocrine Disorders: Is It beyond a Coincidence-A Case Report and Review of the Literature.
    Case Rep Endocrinol 2017 30;2017:4050458. Epub 2017 Oct 30.
    Department of Endocrinology, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.
    Background: Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship is not established. Read More

    Latent autoimmune diabetes of adulthood: case report.
    Clin Diabetes Endocrinol 2017 28;3:11. Epub 2017 Nov 28.
    University of North Carolina (UNC) Family Medicine, 590 Manning Drive, CB#7595, Chapel Hill, NC 27514 USA.
    Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Read More

    Acquired haemophilia A complicating alemtuzumab therapy for multiple sclerosis.
    BMJ Case Rep 2017 Dec 5;2017. Epub 2017 Dec 5.
    Haematology Department, Westmead Hospital, Sydney, New South Wales, Australia.
    Alemtuzumab is a highly efficacious therapy used in the treatment of multiple sclerosis (MS), but uncoupling of T and B cell repopulation during immune reconstitution associates with an increasing range of secondary B cell-mediated autoimmune complications. A 34-year-old woman developed Graves' disease 11 months following an initial course of alemtuzumab treatment for MS. Nine months following the second treatment with alemtuzumab, the patient presented with spontaneous intramuscular and subcutaneous haemorrhage due to development of an inhibitory autoantibody to coagulation factor VIII. Read More

    Cytomegalovirus-mononucleosis-induced thyroiditis in an immunocompetent patient.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 Nov 24.
    Division of Endocrinology, Jewish General Hospital, Montréal, Québec, Canada.
    Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules. The remainder of the physical examination was unremarkable and without stigmata of Graves' disease. Read More

    Hemostasis in Overt and Subclinical Hyperthyroidism.
    Int J Endocrinol Metab 2017 Jul 23;15(3):e44157. Epub 2017 Apr 23.
    Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.
    Context: There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism. Read More

    Successful Prediction of a Left Nonrecurrent Laryngeal Nerve in a Patient With Right-Sided Aorta and Aberrant Left Subclavian Artery.
    Ann Otol Rhinol Laryngol 2017 Dec 1:3489417744318. Epub 2017 Dec 1.
    1 Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
    Background: Left nonrecurrent laryngeal nerve (LNRLN) is an extremely rare anatomic variant. The development of such anatomic variation requires the regression of both the fourth (aortic arch) and sixth (ductus arteriosus, DA) arches on the left side. Preoperative prediction of this variant is difficult but might reduce risk of nerve injury. Read More

    Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study.
    Endocrine 2017 Dec 2. Epub 2017 Dec 2.
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000, Odense, Denmark.
    Purpose: Graves' disease (GD) and toxic nodular goiter (TNG) are associated with various comorbidities. However, it is unclarified whether TNG and GD without orbitopathy are associated with glaucoma.

    Methods: This was a case-control study using record-linkage data from nationwide Danish health registers. Read More

    The association between irisin and muscle metabolism in different thyroid disorders.
    Clin Endocrinol (Oxf) 2017 Dec 2. Epub 2017 Dec 2.
    Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, 49 Przybyszewski St, Poznań, Poland.
    Background: Irisin is a new adipo-myokine, encoded by the FNDC5 gene. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This prospective study assesses the influence of thyrometabolic changes on serum irisin concentration in association with altered muscle metabolism. Read More

    A Synthetic Population for Modelling the Dynamics of Infectious Disease Transmission in American Samoa.
    Sci Rep 2017 Dec 1;7(1):16725. Epub 2017 Dec 1.
    Research School of Population Health, Australian National University, Canberra, Australia.
    Agent-based modelling is a useful approach for capturing heterogeneity in disease transmission. In this study, a synthetic population was developed for American Samoa using an iterative approach based on population census, questionnaire survey and land use data. The population will be used as the basis for a new agent-based model, intended specifically to fill the knowledge gaps about lymphatic filariasis transmission and elimination, but also to be readily adaptable to model other infectious diseases. Read More

    Functional polymorphisms in pre-miR146a and pre-miR499 are associated with systemic lupus erythematosus but not with rheumatoid arthritis or Graves' disease in Mexican patients.
    Oncotarget 2017 Nov 27;8(54):91876-91886. Epub 2017 Jul 27.
    Endocrine and Metabolic Disease Unit Research, Hospital Juarez of Mexico, Mexico City, Mexico.
    Recently, different microRNA (miRNA) gene polymorphisms have been evaluated in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD). In the present study, we examined three single-nucleotide polymorphisms (SNPs) located in the pre-miR-146a (rs2910164G/C), pre-miR-196a-2 (rs11614913C/T), and pre-miR-499 (rs3746444A/G) genes. Our study population included 900 Mexican patients with RA, SLE, or GD, as well as 486 healthy control individuals with no family history of inflammatory or autoimmune diseases. Read More

    A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy.
    J Endocrinol Invest 2017 Nov 30. Epub 2017 Nov 30.
    Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
    Objective: Graves' orbitopathy (GO) is an inflammatory orbital disease of autoimmune origin with the potential to cause severe functional and psychosocial effects. The pathogenesis has not been fully elucidated. We investigated whether DNA methylation was associated with GO incidence in Chinese patients. Read More

    Clinical Significance of a Solitary Cold Thyroid Nodule in the Setting of Graves Disease.
    Clin Nucl Med 2018 Jan;43(1):e27-e28
    From the Nuclear Medicine Service, James A. Haley Veterans' Hospital & Clinics; and University of South Florida Morsani College of Medicine, Tampa, FL.
    I-NaI thyroid uptake and scan in a 46-year-old woman with symptomatic hyperthyroidism demonstrated marked, diffusely increased uptake consistent with Graves disease, as well as a solitary hypofunctioning ("cold") nodule. Pathologic evaluation following total thyroidectomy and selective neck dissection revealed invasive multifocal papillary thyroid carcinoma in a background of Graves disease and 5 of 36 lymph nodes positive for metastatic disease. This case serves as a reminder that when present a cold nodule in the setting of Graves disease warrants further evaluation for underlying malignancy. Read More

    [Management of moderate and severe dysthyroid orbitopathy: about 22 cases].
    Pan Afr Med J 2017 7;27:257. Epub 2017 Aug 7.
    Service d'Ophtalmologie, CHU Farhat Hached, Sousse, Tunisie.
    Our study aimed to describe the therapeutic management of moderate and severe dysthyroid orbitopathies and to evaluate the factors associated with optic neuropathy as well as the prognostic factors of poor visual outcome using a statistical analysis. We conducted a retrospective study of 22 patients presenting with moderate to severe dysthyroid orbitopathy in at least one eye and hospitalized in the Department of Ophthalmology at the University Hospital Farhat Hached, Sousse over the period from 1998 to 2015. Therapeutic indications were based on activity and severity criteria of the Eugogo (European Group On Graves' Orbitopathy) as well as on the assessment of prognostic factors of poor visual outcome. Read More

    Ophthalmic manifestations of endocrine disorders-endocrinology and the eye.
    Transl Pediatr 2017 Oct;6(4):286-299
    Department of Ophthalmology, the Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Disorders of the endocrine system usually manifest in a multi-organ fashion. More specifically, many endocrinopathies become apparent in the eye first through a variety of distinct pathophysiologic disturbances. The eye provides physicians with valuable clues for the recognition and management of numerous systemic diseases, including many disorders of the endocrine pathway. Read More

    Globus symptoms in patients undergoing thyroidectomy: Relationships with psychogenic factors, thyroid disease, and surgical procedure.
    Thyroid 2017 Nov 28. Epub 2017 Nov 28.
    Ito Hospital, Surgery , 4-3-6 Jingumae , Shibuyaku , Tokyo, Japan , 150-0001 ;
    Introduction: The number of patients who need thyroid surgery has increased worldwide in recent decades. Patients with thyroid disease experience globus pharyngeus as a result of direct compression and edema of surrounding organs. Thyroid surgery is needed to improve these symptoms or as treatment for thyroid cancer. Read More

    Graves' Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy.
    Mediterr J Hematol Infect Dis 2017 16;9(1):e2017058. Epub 2017 Oct 16.
    Division of Hematology, University Hospital-Santa Maria Misericordia, Udine, Italy.
    Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. Read More

    Clinical pharmacogenomics: patient perspectives of pharmacogenomic testing and the incidence of actionable test results in a chronic disease cohort.
    Per Med 2017 Sep 1;14(5):383-388. Epub 2017 Sep 1.
    Department of Biological Chemistry & Pharmacology, Ohio State University, Columbus, OH 43210, USA.
    Aim: This study aimed to examine pharmacogenomic test results and patient perspectives at an academic cardiovascular medicine clinic.

    Patients & Methods: Test results for three common cardiovascular drug-gene tests (warfarin-CYP2C9-VKORC1, clopidogrel-CYP2C19 and simvastatin-SLCO1B1) of 208 patients in the Ohio State University-Coriell Personalized Medicine Collaborative were examined to determine the incidence of potentially actionable test results. A post-hoc, anonymous, patient survey was also conducted. Read More

    The long-term outcomes of thyroid function after subtotal thyroidectomy for Graves' hyperthyroidism.
    J Surg Res 2017 Dec 26;220:112-118. Epub 2017 Jul 26.
    Department of Surgery, Chang Gung Memorial Hospital Linkou Branch, Chang Gung University, Taoyuan City, Taiwan (R.O.C.). Electronic address:
    Background: Surgical management of Graves' disease (GD) is changing from subtotal to total thyroidectomy because the latter eliminates the risk of recurrence. However, to preserve thyroid function in a euthyroid state, subtotal thyroidectomy is still performed for GD in non-Western countries. Therefore, we designed a study to investigate the long-term outcomes in GD patients after subtotal thyroidectomy and the correlation between remnant weight and postoperative thyroid function. Read More

    Anticoagulant use in atrial fibrillation and risk of dementia: review of contemporary knowledge.
    Expert Rev Cardiovasc Ther 2017 Dec;15(12):897-903
    a Intermountain Medical Center , Intermountain Heart Institute , Murray , UT , USA.
    Introduction: Atrial fibrillation (AF) is strongly associated with dementia, including idiopathic dementias such as Alzheimer's disease. The relative risk of dementia is highest in AF patients 70 years and younger, and the burden of exposure to arrhythmia appears to underlie part of the risk. Areas covered: Anticoagulation choices and approach influence dementia risk. Read More

    Radioiodine associated de novo Graves' opthalmopathy in an Asian cohort.
    Hell J Nucl Med 2017 Nov 27. Epub 2017 Nov 27.
    Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
    Radioactive iodine in the treatment of Graves' disease has been associated with the development of de novo Graves' ophthalmopathy (GO). In this report, we describe five individuals who required extensive ophthalmic treatment for post-RAI de novo GO. Read More

    Errors in the absorbed and the administered 131I therapeutic dose in patients with Graves' disease. A suggested more precise technique.
    Hell J Nucl Med 2017 Nov 27. Epub 2017 Nov 27.
    Nuclear medicine department of Quanzhou, East Road 248#, Licheng District, Quanzhou City, China, 362000.
    Objective: The aim of this study was to evaluate the relative error (RE) in the thyroid absorbed dose (TD) of iodine-131 (131I) in patients with Graves' disease comparing the simplified Quimby-Marinelli-Hine formula method (sQMHF) and the Standard Operational Procedures for dosimetry (SOPD) recommended by the European Association of Nuclear Medicine.

    Patients And Methods: This study included 45 patients with Graves' disease 12 men and 33 women; age 44.1±12. Read More

    IDIOPATHIC MULTIFOCAL CHOROIDITIS PRESENTING WITH A TRANSIENT PERIPAPILLARY WHITE RING.
    Retin Cases Brief Rep 2017 Nov 22. Epub 2017 Nov 22.
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
    Purpose: We describe with multimodal imaging the presentation and follow-up for a patient with idiopathic multifocal choroiditis and a transient peripapillary white ring.

    Methods: Case report.

    Results: A 39-year-old Asian woman was initially seen for an evaluation of lattice degeneration in 2015. Read More

    Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease.
    Gene 2017 Nov 21. Epub 2017 Nov 21.
    Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India. Electronic address:
    Autoimmune Thyroid Diseases (AITDs), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), arise by the complex interaction of genes and environmental factors. The aim of present study was to study the susceptible associations of HLA-DRB1* alleles and CTLA4 +49 AG polymorphism in AITD in south India. AITD patients (n=235; HT=180; GD=55) and age/sex matched healthy controls (n, 235) were enrolled to type HLA-DRB1* alleles and 'CTLA4 +49 AG' by PCR-SSP and PCR-RFLP methods respectively. Read More

    Yangxin Tongmai formula ameliorates impaired glucose tolerance in children with Graves' disease through upregulation of the insulin receptor levels.
    Acta Pharmacol Sin 2017 Nov 23. Epub 2017 Nov 23.
    Children's Hospital Chongqing Medical University, Chongqing 400000, China.
    Graves' disease (GD) is the leading cause of hyperthyroidism, and the majority of GD patients eventually develop disorders of glucose handling, which further affects their quality of life. Yangxin Tongmai formula (YTF) is modified from a famous formula of traditional Chinese medicine for the treatment of cardiovascular diseases. In this study we investigated the potential effects of YTF in the treatment of pediatric GD patients with impaired glucose tolerance. Read More

    MicroRNA-4443 Causes CD4+ T Cells Dysfunction by Targeting TNFR-Associated Factor 4 in Graves' Disease.
    Front Immunol 2017 1;8:1440. Epub 2017 Nov 1.
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
    Context: Aberrant CD4+ T cell function plays a critical role in the process of Graves' disease (GD). MicroRNAs (miRNAs) are important regulators of T cell activation, proliferation, and cytokine production. However, the contribution of miRNAs to CD4+ T cell dysfunction in GD remains unclear. Read More

    Vitiligo and Autoimmune Thyroid Disorders.
    Front Endocrinol (Lausanne) 2017 27;8:290. Epub 2017 Oct 27.
    Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
    Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Read More

    Biospecimen donation among black and white breast cancer survivors: opportunities to promote precision medicine.
    J Cancer Surviv 2017 Nov 16. Epub 2017 Nov 16.
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
    Purpose: Advances in precision medicine (PM) have potential to reduce and/or eliminate breast cancer disparities in both treatment and survivorship. However, compared to white Americans, black Americans are often underrepresented in genetic research. This report assessed factors that influence receipt of buccal cells via saliva kits. Read More

    The tear cytokine profile in patients with active Graves' orbitopathy.
    Endocrine 2017 Nov 16. Epub 2017 Nov 16.
    Singapore National Eye Centre, Singapore, Singapore.
    Purpose: The primary aim of this study is to isolate cytokines specific for active Graves' orbitopathy (GO) in the tears of affected patients. The secondary aim is to identify other cytokines of interest and to look at the profile of their levels over time.

    Methods: This is a prospective pilot study conducted at the Singapore National Eye Centre. Read More

    RELATIONSHIP BETWEEN THE EFFECTIVENESS OF INORGANIC IODINE AND THE SEVERITY OF GRAVES' THYROTOXICOSIS: A RETROSPECTIVE STUDY.
    Endocr Pract 2017 Nov 16. Epub 2017 Nov 16.
    From: Department of Metabolism & Endocrinology, Juntendo University Graduate School, Tokyo, Japan.
    Objective: Inorganic iodine is often used to treat patients with Graves' thyrotoxicosis who do not tolerate thionamides due to adverse effects. However, predictors of continued inorganic iodine efficacy have not been fully elucidated yet. This study aimed to investigate the factors affecting the continued efficacy of potassium iodide (KI) in patients with Graves' thyrotoxicosis. Read More

    Preoperative management in patients with Graves' disease.
    Gland Surg 2017 Oct;6(5):476-481
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. Read More

    Examining the contributions of environmental quality to pediatric multiple sclerosis.
    Mult Scler Relat Disord 2017 Nov 7;18:164-169. Epub 2017 Sep 7.
    University of California San Francisco, San Francisco, CA, United States.
    Background: Multiple sclerosis (MS) is a presumed autoimmune disease caused by genetic and environmental factors. It is hypothesized that environmental exposures (such as air and water quality) trigger the innate immune response thereby activating a pro-inflammatory cascade.

    Objective: To examine potential environmental factors in pediatric MS using geographic information systems (GIS). Read More

    [Hyperthyroidism in children at the University Hospital in Dakar (Senegal)].
    Pan Afr Med J 2017 7;28:10. Epub 2017 Sep 7.
    Clinique Médicale II/Centre Hospitalier Abass Ndao/UCAD, Dakar, Sénégal.
    Introduction: Hyperthyroidism in children is rare and constitutes a problem because of its psychosomatic impact. This study aimed to present an overview of the state of knowledge on these aspects in children from Dakar.

    Methods: We conducted a multicenter, descriptive study over a period of 15 years. Read More

    Graves disease following radioiodine therapy for toxic adenoma: Clinical case report.
    Medicine (Baltimore) 2017 Nov;96(45):e8550
    Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Rationale: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma.

    Patient Concerns: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. Read More

    Study of the Factors Leading to Fetal and Neonatal Dysthyroidism in Children of Patients With Graves Disease.
    J Endocr Soc 2017 Jun 25;1(6):751-761. Epub 2017 Apr 25.
    Department of Neonatology, Obstetrics and Gynecology, University Hospitals Paris Nord Val de Seine, Assistance Publique Hôpitaux de Paris, Beaujon Hospital, Clichy 92118, France.
    Context: Neonatal hyperthyroidism was first described in 1912 and in 1964 was shown to be linked to transplacental passage of maternal antibodies. Few multicenter studies have described the perinatal factors leading to fetal and neonatal dysthyroidism.

    Objective: To show how fetal dysthyroidism (FD) and neonatal dysthyroidism (ND) can be predicted from perinatal variables, in particular, the levels of anti-thyrotropin receptor antibodies (TRAbs) circulating in the mother and child. Read More

    Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature.
    J Pediatr Endocrinol Metab 2017 Nov;30(12):1237-1243
    .
    Background: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. Read More

    Astragaloside IV attenuates orbital inflammation in Graves' orbitopathy through suppression of autophagy.
    Inflamm Res 2017 Nov 10. Epub 2017 Nov 10.
    Department of Endocrinology, Shanghai University of Traditional Chinese Medicine Longhua Affiliated Hospital, 725 South Wanpin Road, Shanghai, 200032, People's Republic of China.
    Introduction: Graves' orbitopathy (GO) is an autoimmune inflammatory disorder affecting the orbit around the eye. Astragaloside IV (AS-VI) is the main active ingredient of the Chinese herbal medicine Huangqi (Radix Astragali Mongolici). AS-IV exhibits antioxidant and anti-inflammatory properties, and shows therapeutic potential in a number of ischemic and inflammatory diseases; however, its pharmaceutical activities in GO remain undefined. Read More

    The 2017 Doyne Lecture: the orbit as a window to systemic disease.
    Eye (Lond) 2017 Nov 10. Epub 2017 Nov 10.
    Orbital Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital, and Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.
    A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Read More

    THE VALUE OF MULTIDETECTOR COMPUTED TOMOGRAPHY OF ORBITS IN GLOBE PROTRUSION IN COMPARISON TO HERTEL EXOPHTHALMOMETRY.
    Acta Clin Croat 2017 03;56(1):21-7
    The use of multidetector computed tomography (MDCT) is an integral part of contemporary diagnostics of Graves‘ orbitopathy. The aim of this study was to assess proptosis measurement by MDCT and to compare it to the current standard, Hertel exophthalmometry. A cross-sectional study was conducted at the Clinical Centre of Serbia and included 91 patients (19 male and 72 female) with verified Graves‘ orbitopathy. Read More

    Prediction of thyroidal 131I effective half-life in patients with Graves' disease.
    Oncotarget 2017 Oct 12;8(46):80934-80940. Epub 2017 Sep 12.
    Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.
    Purpose: Calculation of effective thyroidal half-life (Teff) of iodine-131(131I) is cumbersome and tedious. The aim of this study was to investigate factors that could be used to predict Teff and to develop a Teff prediction model in Graves' disease patients.

    Methods: A total of 256 patients with GD were involved in this study. Read More

    Impact of potassium iodide on thyroidectomy for Graves' disease: Implications for safety and operative difficulty.
    Surgery 2017 Nov 3. Epub 2017 Nov 3.
    Department of Surgery, University of Wisconsin, Madison, WI.
    Background: Potassium iodide often is prescribed prior to thyroidectomy for Graves' disease, but the effect of potassium iodide on the ease and safety of thyroidectomy for Graves' is largely unknown.

    Methods: We conducted a prospective, cohort study of patients with Graves' disease undergoing thyroidectomy. For the first 8 months, no patients received potassium iodide; for the next 8 months, potassium iodide was added to the preoperative protocol for all patients. Read More

    Comparative study of 3 exophthalmometers and computed tomographic biometry.
    Eur J Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Ophthalmology, Limoges Hospital, Limoges - France.
    Purpose:: Accurate and reproducible exophthalmometry is mandatory to diagnose and follow-up orbital patients, especially in Graves disease. However, many variations are described among the different commercially available exophthalmometers.

    Methods:: Sixty patients, who underwent a cerebral computed tomography (CT) scan, were included. Read More

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