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    Malignant Hyperthermia Versus Thyroid Storm in a Patient With Symptomatic Graves Disease: A Case Report.
    A A Case Rep 2017 Oct 12. Epub 2017 Oct 12.
    From the Department of Anesthesiology, Loyola University Medical Center, Maywood, Illinois.
    Malignant hyperthermia and thyroid storm are intraoperative emergencies with overlapping symptoms but different treatment protocols. We faced this diagnostic dilemma in a 25-year-old patient with symptomatic hyperthyroidism, elevated free T3 and free T4, and low thyroid-stimulating hormone from Graves disease despite treatment with propranolol 80 mg daily and methimazole 40 mg every 8 hours. During thyroidectomy, he developed hyperthermia and hypercarbia without tachycardia. Read More

    A Comparative Study of Full-Thickness Blepharotomy Versus Transconjunctival Eyelid Lengthening in the Correction of Upper Eyelid Retraction in Graves' Orbitopathy.
    Aesthetic Plast Surg 2017 Oct 12. Epub 2017 Oct 12.
    Division of Ophthalmology, Laboratory for Investigation in Ophthalmology (LIM-33), University of São Paulo Medical School, Av. Dr. Arnaldo, 455, São Paulo, SP, 01246-903, Brazil.
    Background: The study was designed to compare the outcome of full-thickness blepharotomy and transconjunctival eyelid lengthening in the correction of upper eyelid retraction (UER) in patients with Graves' orbitopathy (GO).

    Methods: This is a prospective randomized interventional study. Following ophthalmic examination, determination of the ocular surface disease index (OSDI) and photography, 27 patients with UER were randomly assigned to either graded full-thickness blepharotomy (G1) or transconjunctival Müller muscle recession and graded disinsertion of the levator palpebrae superioris muscle (G2). Read More

    Five cases of childhood-onset Graves' disease treated with either surgery or radio-iodine therapy.
    Clin Pediatr Endocrinol 2017 28;26(4):265-269. Epub 2017 Sep 28.
    Division of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
    There are three major therapeutic options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. Read More

    Weight Gain After Treatment of Graves' Disease in Children.
    Clin Endocrinol (Oxf) 2017 Oct 12. Epub 2017 Oct 12.
    UT Southwestern Medical Center, Dallas, TX.
    Objective: The frequency of and risk factors for weight gain in children treated for Graves disease have not been described. We evaluated change in BMI Z score and predictors of weight gain in this population.

    Design: Retrospective review of data from January 2000 to July 2011. Read More

    Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis.
    J Neurol Neurosurg Psychiatry 2017 Oct 9. Epub 2017 Oct 9.
    Department of Neurology, UCSF Regional Pediatric MS Center, San Francisco, California, USA.
    Objective: The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers. Read More

    Autoimmune endocrine diseases.
    Minerva Endocrinol 2017 Oct 9. Epub 2017 Oct 9.
    Unit of Nuclear Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
    The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Read More

    [IgG4-related disease - a case report].
    Pol Merkur Lekarski 2017 Sep;43(255):129-132
    Medical University of Warsaw: Department of Internal Medicine and Endocrinology.
    Immunoglobulin G4-related disease (IgG4-RD) is a comparatively new condition that may involve more than one organ. The lack of characteristic, pathognomonic clinical symptoms may delay the diagnosis of this disease. The diagnosis is based upon clinical manifestation, elevated serum levels of IgG4 and histopathologic examination with immunohistochemical staining to reveal infiltration of IgG4-positive plasma cells. Read More

    Resource utilization associated with cervical hematoma after thyroid and parathyroid surgery.
    J Surg Res 2017 Oct 8;218:67-77. Epub 2017 May 8.
    Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania. Electronic address:
    Background: Postoperative cervical hematoma (PCH) after thyroid and parathyroid surgery is a well-known complication. This study used data from the Nationwide Inpatient Sample to identify risk factors, estimate mortality, length of stay (LOS), and total costs attributable to PCH in patients undergoing procedures for thyroid and parathyroid diseases.

    Methods: Patients aged >18 y who underwent thyroid or parathyroid surgery between 2001 and 2011 were identified and stratified by the occurrence of PCH. Read More

    Genetic risk factors for pediatric-onset multiple sclerosis.
    Mult Scler 2017 Oct 1:1352458517733551. Epub 2017 Oct 1.
    Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
    Background: Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology.

    Objective: We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS.

    Methods: Cases with onset <18 years ( n = 569) and controls ( n = 16,251) were included from the United States and Sweden. Read More

    Incidence of Hypothyreoidism after Radioactive Iodine-I131 Treatment in Dependance of Hyperthyreoidism Etiology and Therapy Dose.
    Med Arch 2017 Aug;71(4):270-273
    Clinic of Nuclear Medicine and Endocrinology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
    Introduction: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments.

    Aim: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses. Read More

    Treatment of Graves' ophthalmopathy with an in-house Phosphorus-32 source: Initial clinical observations.
    Exp Ther Med 2017 Oct 9;14(4):2795-2800. Epub 2017 Aug 9.
    Department of Nuclear Medicine, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
    The objective of the present study was to observe the therapeutic effect of radiation delivered via a (32)P source on Graves' ophthalmopathy. A(32)P solution was injected into a 10-ml vacuum flask held inside a lead container. A window was cut in the lead, generating a treatment beam. Read More

    A novel data-driven workflow combining literature and electronic health records to estimate comorbidities burden for a specific disease: a case study on autoimmune comorbidities in patients with celiac disease.
    BMC Med Inform Decis Mak 2017 Sep 29;17(1):140. Epub 2017 Sep 29.
    Georges Pompidou European Hospital (HEGP), AP-HP, Paris, France.
    Background: Data collected in EHRs have been widely used to identifying specific conditions; however there is still a need for methods to define comorbidities and sources to identify comorbidities burden. We propose an approach to assess comorbidities burden for a specific disease using the literature and EHR data sources in the case of autoimmune diseases in celiac disease (CD).

    Methods: We generated a restricted set of comorbidities using the literature (via the MeSH® co-occurrence file). Read More

    Associations of melatonin receptor gene polymorphisms with Graves' disease.
    PLoS One 2017 29;12(9):e0185529. Epub 2017 Sep 29.
    Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
    Background: Melatonin plays an important role in immunity and has been linked to autoimmune diseases. Possible associations of single-nucleotide polymorphisms (SNPs) of melatonin receptor type 1A (MTNR1A) and 1B (MTNR1B), with autoimmune thyroid disease in an ethnic Chinese (i.e. Read More

    Anti-ICOS Monoclonal Antibody Treatment of Canine Chronic GVHD.
    Biol Blood Marrow Transplant 2017 Sep 25. Epub 2017 Sep 25.
    Transplantation Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, Division of Oncology, University of Washington, Seattle, Washington. Electronic address:
    In murine model systems, inducible costimulator (ICOS) signaling has been implicated in the formation of chronic graft-versus-host disease (GVHD). Previously, we showed that chronic GVHD can be reproducibly produced in the dog hematopoietic cell transplantation (HCT) model and that ICOS expression is upregulated on T cells in dogs with chronic GVHD. The goal of the present study was to determine whether administration of a short course of anti-canine ICOS monoclonal antibody (mAb) could alter the rapid and progressive course of chronic GVHD. Read More

    A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
    SLAS Discov 2017 Sep 1:2472555217732014. Epub 2017 Sep 1.
    1 GlaxoSmithKline, Collegeville, PA, USA.
    A persistent problem in early small-molecule drug discovery is the frequent lack of rank-order correlation between biochemical potencies derived from initial screens using purified proteins and the diminished potency and efficacy observed in subsequent disease-relevant cellular phenotypic assays. The introduction of the cellular thermal shift assay (CETSA) has bridged this gap by enabling assessment of drug target engagement directly in live cells based on ligand-induced changes in protein thermal stability. Initial success in applying CETSA across multiple drug target classes motivated our investigation into replacing the low-throughput, manually intensive Western blot readout with a quantitative, automated higher-throughput assay that would provide sufficient capacity to use CETSA as a primary hit qualification strategy. Read More

    Methimazole-induced liver injury overshadowed by methylprednisolone pulse therapy: Case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8159
    aInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences bInstitute of Endocrinology, Lithuanian University of Health Sciences cInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Rationale: Treatment choices are limited, when deciding how to manage thyrotoxicosis and moderate to severe Graves ophthalmopathy (GO) with suspected optic nerve damage in patients with elevated liver transaminase levels. The situation become even more complicated, if methimazole induced hepatotoxicity is suspected and intravenous methylprednisolone is co-administrated.

    Patient Concerns: A 74-year-old woman presented with spontaneous retro-bulbar pain, eyelid swelling and inconstant diplopia. Read More

    The Association of Thyrotropin and Autoimmune Thyroid Disease in Developing Papillary Thyroid Cancer.
    Int J Endocrinol 2017 29;2017:5940367. Epub 2017 Aug 29.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
    Background: Papillary thyroid carcinoma (PTC) is the most common type of malignant thyroid neoplasm. However, the incidence of PTC with autoimmune thyroid disease (AITD) varies between studies. This study aims to investigate whether patients with AITD have increased incidence of PTC. Read More

    Neonatal Graves' Disease with Maternal Hypothyroidism.
    AJP Rep 2017 Jul 22;7(3):e181-e184. Epub 2017 Sep 22.
    Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri.
    Neonatal Graves' disease presenting as conjugated hyperbilirubinemia is a diagnostic challenge because the differential includes a gamut of liver and systemic diseases. We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Read More

    Long-term impact of endoscopic orbital decompression on sinonasal-specific quality of life.
    Laryngoscope 2017 Sep 25. Epub 2017 Sep 25.
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Objective: Endoscopic orbital decompression (EOD) is the workhorse surgical intervention for severe thyroid eye disease in Graves disease. Although EOD is a safe and effective procedure. The objective of this study is to determine the impact of orbital decompression on long-term sinonasal-specific quality of life. Read More

    Recurrent Graves' hyperthyroidism after prolonged radioiodine-induced hypothyroidism.
    Ther Adv Endocrinol Metab 2017 Jul 12;8(7):111-115. Epub 2017 Sep 12.
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, 920 Madison Ave, Suite 300A, Memphis TN 38163, USA.
    Background: Radioactive iodine (RAI) is the most cost effective therapy for Graves' disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. Read More

    Is Graves' disease a primary immunodeficiency? New immunological perspectives on an endocrine disease.
    BMC Med 2017 Sep 25;15(1):174. Epub 2017 Sep 25.
    Medical University Department, Clinic for Endocrinology, Diabetes & Metabolism, Kantonsspital Aarau, Aarau, Switzerland.
    Background: Uncertainty about factors influencing the susceptibility and triggers for Graves' disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-responders. The aim of this narrative review is to summarize immunological concepts, with a combined endocrine and immunological perspective, to highlight potential new areas of research.

    Main Text: Relevant studies were identified through a systematic literature search using the PubMed and EMBASE databases in March 2016. Read More

    Regulation of orbital fibrosis and adipogenesis by pathogenic Th17 cells in Graves' orbitopathy.
    J Clin Endocrinol Metab 2017 Aug 16. Epub 2017 Aug 16.
    Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai.
    Context: Th17 cells are correlated with many human autoimmune disorders including Graves' disease, and may play key roles in the pathogenesis of Graves' orbitopathy (GO).

    Objective: To study the phenotype of Th17 cells in patients with GO and healthy subjects, investigate the fibrosis and adipogenesis in orbital fibroblasts (OFs) modulated by IL-17A, and determine the interaction between Th17 cells and OFs.

    Design/setting/participants: Blood samples and orbital tissues from GO patients and healthy controls were collected. Read More

    Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China.
    Sci Rep 2017 Sep 20;7(1):11950. Epub 2017 Sep 20.
    Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, The People's Republic of China.
    Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte antigen (HLA) and nearby genes in Southeast Asian and European populations. The susceptibility of the Han population from northern China to ATD-induced agranulocytosis has not been reported. We evaluated the associations of genetic variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced agranulocytosis and in 140 patients with Graves' disease (GD) as controls. Read More

    Thyroid Function Testing in Neonates With Maternal History of Disease.
    Clin Pediatr (Phila) 2017 Sep 1:9922817729484. Epub 2017 Sep 1.
    1 Children's Hospital at Montefiore, Bronx, NY, USA.
    Maternal history of thyroid disease can cause congenital hypothyroidism due to thyroid-stimulatng hormone (TSH) blocking antibodies. No guidelines exist regarding testing beyond the newborn screen. TSH and T4 levels exhibit significant fluctuations after birth which complicates testing. Read More

    Anti-parietal cell antibodies in patients with autoimmune thyroid diseases.
    J Endocrinol Invest 2017 Sep 19. Epub 2017 Sep 19.
    Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná, Rua Padre Camargo, 280, 80060-240, Curitiba, Brazil.
    Background: Autoimmune thyroid disease (ATD) patients may have a higher prevalence of anti-parietal cell antibodies (APCA) than normal population.

    Objective: To study the prevalence of APCA in a cohort of ATD patients to know its association with patient's clinical profile and gastrointestinal complaints.

    Methods: APCA was sought for by indirect immunofluorescence test in 243 ATD patients: 136 (55. Read More

    Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping mass drug administration.
    PLoS Negl Trop Dis 2017 Sep 18;11(9):e0005914. Epub 2017 Sep 18.
    Australian Institute of Tropical Health and Medicine and College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Australia.
    The Global Programme to Eliminate Lymphatic Filariasis (LF) aims to eliminate the disease as a public health problem by 2020 by conducting mass drug administration (MDA) and controlling morbidity. Once elimination targets have been reached, surveillance is critical for ensuring that programmatic gains are sustained, and challenges include timely identification of residual areas of transmission. WHO guidelines encourage cost-efficient surveillance, such as integration with other population-based surveys. Read More

    Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.
    Lancet Neurol 2017 Oct 12;16(10):797-812. Epub 2017 Sep 12.
    Department of Neurology, Amsterdam Neuroscience, VUmc MS Center Amsterdam and Dutch Expertise Centre for Neuro-ophthalmology, VU University Medical Center, Amsterdam, Netherlands.
    Background: Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in multiple sclerosis when measured with SD-OCT. Read More

    Association of Human Leukocyte Antigens Class I and II with Graves' Disease in Iranian Population.
    Iran J Immunol 2017 Sep;14(3):223-230
    Department of Cellular and Molecular Biology, Kish International Campus, University of Tehran, Kish Island, Iran.
    Background: Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. Read More

    A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?
    Am J Surg 2017 Oct 23;214(4):629-633. Epub 2017 Jun 23.
    Moffitt Cancer Center, Tampa, USA. Electronic address:
    Background: Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited.

    Methods: A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and ≥70. Read More

    Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients.
    Int J Endocrinol 2017 20;2017:2304218. Epub 2017 Aug 20.
    Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
    Background: Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD.

    Methods: Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls.

    Results: GD showed higher frequencies of the TLR4 rs1927911 C allele than control. Read More

    Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
    N Engl J Med 2017 09 14;377(13):1228-1239. Epub 2017 Sep 14.
    From the Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford (R.R.H., M.A.B.), and the International Centre for Circulatory Health, Imperial College London, London (N.P.) - both in the United Kingdom; Duke Clinical Research Institute, Duke University School of Medicine, Durham (R.J.M., V.P.T., Y.L., N.J.P., A.F.H.), and the Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill (J.B.B.) - both in North Carolina; the Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong (J.C.C.); AstraZeneca Research and Development, Gaithersburg, MD (J.C., S.M.G., N.I., P.Ö.); Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Research Center, Florence, Italy (A.P.M.); the Department of Cardiology, University of Texas Southwestern Medical Center, Dallas (S.P.M.); the India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India (A.R.); and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and University of Toronto, Toronto (B.Z.).
    Background: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.

    Methods: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. Read More

    The Role of Vitamin D in Thyroid Diseases.
    Int J Mol Sci 2017 Sep 12;18(9). Epub 2017 Sep 12.
    Division of Endocrinology, Department of Internal Medicine, Dankook University College of Medicine, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 330-714, Korea.
    The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, and impaired vitamin D signaling has been reported in thyroid cancers. Read More

    Serum Free T3 to Free T4 Ratio as a Useful Indicator for Differentiating Destruction Induced Thyrotoxicosis from Graves' Disease.
    J Clin Diagn Res 2017 Jul 1;11(7):OC12-OC14. Epub 2017 Jul 1.
    Resident Doctor, Department of Biochemistry, Institute of Medicine, Kathmandu, Nepal.
    Introduction: Thyrotoxicosis is a common disease encountered in Endocrine Outpatient Department (OPD). Two common causes of thyrotoxicosis are Destruction Induced Thyrotoxicosis (DIT) and Graves' Disease (GD). Differentiating DIT and GD based on clinical findings, is often not possible due to nonspecific symptoms. Read More

    Effect of treatment with epoprostenol and endothelin receptor antagonists on the development of thyrotoxicosis in patients with pulmonary arterial hypertension.
    Endocr J 2017 Sep 9. Epub 2017 Sep 9.
    Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University, Tokyo 143-8540, Japan.
    Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HPAH who had been diagnosed with PAH before the age of 20 years. Read More

    A case of metastatic follicular thyroid carcinoma complicated with Graves' disease after total thyroidectomy.
    Endocr J 2017 Sep 5. Epub 2017 Sep 5.
    Department of Thoracic, Endocrine Surgery and Oncology, Institute of Health, Biosciences, The University of Tokushima, Tokushima 770-8509, Japan.
    Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. Read More

    Hickam's dictum: Myasthenia Gravis presenting concurrently with Graves' disease.
    BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.
    Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand.
    We present two patients with Graves' disease and concurrent myasthenia gravis. The impact of the dual diagnosis on the clinical course and the potential for a delayed diagnosis of myasthenia gravis is discussed. Patient 1, a 28-year-old man was diagnosed with Graves' disease following his second respiratory arrest. Read More

    Yonsei Experience of 5000 Gasless Transaxillary Robotic Thyroidectomies.
    World J Surg 2017 Sep 6. Epub 2017 Sep 6.
    Department of Surgery, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
    Background: Since the use of robot systems in thyroid surgery was introduced in 2007, we have advanced a novel method of robotic thyroidectomy (RT) using a gasless transaxillary approach (TAA). We report our experience with this technique and detail the surgical outcome of 5000 robotic thyroidectomies.

    Methods: From October 2007 to May 2016, we successfully performed 5000 robotic thyroidectomies using a gasless TAA at the Department of Surgery, Yonsei University Health System. Read More

    Thyroid Association Ophthalmopathy in Hashimoto's Thyroiditis: a Case Report.
    Maedica (Buchar) 2017 Jan;12(1):65-67
    Assistant Professor, Department of Pathology, Pt.B.D.Sharma PGIMS, Rohtak, India.
    Thyroid associated ophthalmopathy is a constellation of symptoms caused by an autoimmune process involving the orbital tissue. It is common in hyperthyroid patients due to Graves' disease and also reported in euthyroid and hypothyroid Graves' patients with positive thyroid receptor antibodies. But in Hashimoto's thyroiditis, thyroid associated ophthalmopathy is a rarely reported and poorly understood entity. Read More

    [Serum level of chemerin and bone mineral density in patients with Graves disease].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):947-952
    Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To investigate relationships between serum chemerin and bone mineral density (BMD) in patients with newly diagnosed Graves disease (GD).
 Methods: A total of 120 newly diagnosed GD patients with a course more than 3 months were enrolled from the Department of Endocrinology between June 2013 and June 2015. Sixty age- and sex-matched healthy people served as a normal control. Read More

    Search for relevant indications for selenium supplementation in thyroid diseases.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):237-241. Epub 2017 Aug 5.
    Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
    Selenium plays a significant role in the thyroid function and its deficiency is considered by some authors to be a cause of thyroid disorders. The potential therapeutic influence of selenium supplementation in thyroid disease was investigated in several studies and some results were encouraging, however results were inconsistent and did not allow conclusion to be drawn. For that reason, we have performed a review study on relevance of selenium supplementation in thyroid disease. Read More

    Thyroid storm and warm autoimmune hemolytic anemia.
    Transfus Apher Sci 2017 Aug 18;56(4):606-608. Epub 2017 Aug 18.
    Division of Hematology Oncology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, United States.
    Graves' disease is often associated with other autoimmune disorders, including rare associations with autoimmune hemolytic anemia (AIHA). We describe a unique presentation of thyroid storm and warm AIHA diagnosed concurrently in a young female with hyperthyroidism. The patient presented with nausea, vomiting, diarrhea and altered mental status. Read More

    Dr Google: The readability and accuracy of patient education websites for Graves' disease treatment.
    Surgery 2017 Aug 29. Epub 2017 Aug 29.
    Department of Surgery, University of California Irvine Medical Center, Orange, CA. Electronic address:
    Background: National guidelines emphasize the importance of incorporating patient preferences into the recommendations for the treatment of Graves' disease. Many patients use the Internet to obtain health information, and search results can affect their treatment decisions. This study compares the readability and accuracy of patient-oriented online resources for the treatment of Graves' disease by website affiliation and treatment modality. Read More

    Orbital flourine-18-fluorodeoxyglucose positron emission tomography in patients with Graves' disease for evaluation of active inflammation.
    Nucl Med Commun 2017 Aug 31. Epub 2017 Aug 31.
    Departments of aNuclear Medicine bOphthalmology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih/Istanbul, Turkey.
    Objective: Prediction and early diagnosis of orbitopathy is needed in patients with Graves' disease, especially when radioiodine therapy is planned. Positron emission tomography/computerized tomography (PET/CT) using flourine-18-fluorodeoxyglucose (FDG) is an effective imaging modality in detection of inflammation, however, its ability to detect orbital inflammation has not been well studied. The aim of our study is to determine the ability of FDG PET/CT to detect orbital inflammation related with Graves' disease, identify active orbitopathy, predict the radioiodine-triggered orbitopathy, and find out the effects of radioiodine on orbital inflammation. Read More

    Epstein-Barr virus-encoded small RNAs in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series.
    Int J Ophthalmol 2017 18;10(8):1268-1272. Epub 2017 Aug 18.
    Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
    Aim: To investigate the positive rate and types of cells that express Epstein-Barr virus-encoded small RNAs (EBERs) and to determine the distribution of EBER-expressing cells in idiopathic orbital inflammatory pseudotumor (IOIP) tissues.

    Methods: We retrospectively examined 40 archived paraffin specimens from two teaching hospitals in Southern China between January 2007 and January 2015 that were pathologically determined to exhibit IOIP. Eleven concurrent paraffin specimens of thyroid-associated ophthalmopathy (TAO) composed the control group. Read More

    Fat-removal orbital decompression for thyroid associated orbitopathy: The right procedure for the right patient.
    Saudi J Ophthalmol 2017 Jul-Sep;31(3):156-161. Epub 2017 Jun 14.
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Orbital decompression is an effective and invaluable procedure for addressing some of the chronic manifestations of Graves' Ophthalmopathy (GO) such as exophthalmos and orbital congestion. Fat-removal orbital decompression (FROD) started to gain popularity after its introduction in the late 20th century. Among the therapeutic armamentarium of techniques and approaches available for orbital decompression, FROD has proven its efficacy and safety in addition to its ability to reduce proptosis in a relatively predictable manner. Read More

    Impaired decision making under risky conditions in the acute phase of Graves' thyroitoxicosis.
    Neurosci Lett 2017 Aug 30;661:1-4. Epub 2017 Aug 30.
    Department of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, PR China. Electronic address:
    The patients with Graves' thyroitoxicosis often complain that they have neuropsychiatric symptoms and impaired cognitive function. Decision making is important and complex process involving the interaction and integration of a series of cognitive components. In the 31 newly diagnosed patients with Graves' thyroitoxicosis and 30 healthy controls, we used the Hamilton Anxiety Rating Scale (HAMD), Hamilton Depression Rating Scale (HAMD) and The Game of Dice Task (GDT) to assess the emotion and decision making under risky conditions. Read More

    Use of low-dose radioiodine ablation for Graves' orbitopathy: results of a pilot, perspective study in a small series of patients.
    J Endocrinol Invest 2017 Aug 30. Epub 2017 Aug 30.
    Department of Clinical and Experimental Medicine, Endocrinology Unit I, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.
    Objective: Elimination of thyroid antigens by total thyroid ablation (TTA), namely, thyroidectomy followed by radioiodine, may be beneficial for Graves' Orbitopathy (GO). TTA is usually performed with a (131)I dose of 30 mCi. In Italy, this dose must be followed by a 24-h protected hospitalization, with increase in the waiting lists. Read More

    Sarcoidosis and Thyroid Autoimmunity.
    Front Endocrinol (Lausanne) 2017 8;8:177. Epub 2017 Aug 8.
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
    Most of the studies have shown a higher risk for subclinical and clinical hypothyroidism, antithyroid autoantibodies [overall antithyroid peroxidase antibodies (TPOAb)], and in general, thyroid autoimmunity, overall in the female gender in patients with sarcoidosis (S). A significantly higher prevalence of clinical hypothyroidism and Graves' disease was also described in female S patients with respect to controls. Gallium-67 (Ga-67) scyntigraphy in S patients, in the case of thyroid uptake, suggests the presence of aggressive autoimmune thyroiditis and hypothyroidism. Read More

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