21,130 results match your criteria Graves Disease


Decreased circulating levels of ANGPTL8 in Graves' disease patients.

Hormones (Athens) 2019 Mar 21. Epub 2019 Mar 21.

Department of Endocrinology, Affiliated Hospital of Jiangsu University, 438, Jiefang Road, Zhenjiang, 212001, Jiangsu, China.

Background: Angiopoietin-like protein 8 (ANGPTL8), a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. However, little is as yet known as to whether circulating ANGPTL8 levels are altered in thyroid dysfunction. This study measured serum ANGPTL8 levels in patients with Graves' disease and explored the correlations between its serum levels and thyroid index in Graves' disease. Read More

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http://dx.doi.org/10.1007/s42000-019-00095-8DOI Listing

Rapid Changes of Thyroid Function in a Young Woman with Autoimmune Thyroid Disease.

Med Princ Pract 2019 Mar 22. Epub 2019 Mar 22.

Objective
A conversion from Hashimoto's thyroiditis (HT) to Graves' disease (GD) and vice versa leads to diagnostic and therapeutic challenges.
Clinical Presentation and Intervention
A 30-year old woman presented with overt hyperthyroidism and negative thyroid-stimulating hormone receptor antibodies (TRAbs). Since hashitoxicosis was assumed, the patient was treated with propranolol. Read More

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http://dx.doi.org/10.1159/000499754DOI Listing

DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease.

Eur J Endocrinol 2019 Mar 1. Epub 2019 Mar 1.

L Chiovato, Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., University of Pavia, Pavia, Italy.

IgG4-related disease (IgG4-RD) is fibro-inflammatory, immune-mediated, systemic disease, recognized as a defined clinical condition only in 2001. The prevalence of IgG4-RD is 6/100,000 but it is likely to be underestimated due to insufficient awareness of the disease. The diagnostic approach is complex because of the heterogeneity of clinical presentation and because of rather variable diagnostic criteria. Read More

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http://dx.doi.org/10.1530/EJE-18-1024DOI Listing
March 2019
1 Read

The role of thyroglobulin in thyroid hormonogenesis.

Nat Rev Endocrinol 2019 Mar 18. Epub 2019 Mar 18.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

In humans, the thyroid hormones T and T are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T and T at distinct sites. Read More

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http://dx.doi.org/10.1038/s41574-019-0184-8DOI Listing
March 2019
1 Read

Thyroid storm and myxoedema: two reversible causes of acute heart failure.

Acute Med 2018 ;17(4):229-231

Department of Intensive Medicine, Unidade de Saúde Local de Matosinhos, Matosinhos, Portugal.

Cardiovascular signs and symptoms can prevail in both hypothyroidism and hyperthyroidism. Case 1: 30-year-old female with acute right heart failure as first manifestation of Graves' disease. It illustrates some of its cardiovascular complications, particularly pulmonary hypertension, tricuspid regurgitation, atrial fibrillation, mitral valve prolapse and mitral regurgitation. Read More

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January 2018

Serum levels of insulin-like growth factor 1 are negatively associated with log transformation of thyroid-stimulating hormone in Graves' disease patients with hyperthyroidism or subjects with euthyroidism: A prospective observational study.

Medicine (Baltimore) 2019 Mar;98(11):e14862

Department of Internal Medicine, National Taiwan University Hospital.

Insulin-like growth factor 1 (IGF-1) has a molecular structure similar to that of insulin. As an essential mediator of growth hormone, IGF-1 plays a vital role in growth of children and anabolic effects of adults. We evaluated the serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism. Read More

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http://dx.doi.org/10.1097/MD.0000000000014862DOI Listing
March 2019
1 Read

Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves' Ophthalmopathy: Good Results After Long-Term Follow-Up.

Int J Endocrinol Metab 2019 Jan 27;17(1):e84427. Epub 2019 Jan 27.

Department of Radiation Oncology, Sant' Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Background: Orbital radiotherapy (RT) is an effective and consolidate treatment for steroid-refractory Graves' ophthalmopathy (GO); however, long term effects are not well known.

Objectives: The aim of this study was to evaluate the long term efficacy and toxicity of orbital RT plus concomitant systemic steroids in a population of patients with moderate-to-severe GO or with eyesight threatening symptoms refractory to steroids.

Methods: Forty patients with moderate-to-severe GO or with eyesight threatening symptoms not responsive/resistant to steroids were treated with orbital RT at the dose of 20 Gy in 10 fractions plus concomitant steroids. Read More

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http://dx.doi.org/10.5812/ijem.84427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408739PMC
January 2019

Factors Predicting Time to TSH Normalization and Persistence of TSH Suppression After Total Thyroidectomy for Graves' Disease.

Front Endocrinol (Lausanne) 2019 1;10:95. Epub 2019 Mar 1.

Department of Endocrinology, Università Cattolica del Sacro Cuore, Rome, Italy.

Hyperthyroidism related to Graves' disease is associated with a suppression of TSH values which may persist after surgery in spite of a LT replacement therapy at non-TSH-suppressing doses. The aim of this retrospective study was to evaluate the time to TSH normalization in a group of patients who underwent total thyroidectomy for Graves' disease receiving a LT therapy dose regimen based on a previously published nomogram, and to identify possible correlations between the time to normalization of post-operative TSH values and preoperative clinical and biochemical parameters. 276 patients affected by Graves' disease who underwent surgery between 2010 and 2015, were retrospectively evaluated for clinical and biochemical parameters as well as post-surgical LT4 treatment regimen. Read More

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http://dx.doi.org/10.3389/fendo.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405427PMC
March 2019
1 Read

Muscle performance and postural stability are reduced in patients with newly diagnosed Graves' disease.

Thyroid 2019 Mar 18. Epub 2019 Mar 18.

Aarhus Universitetshospital, 11297, Department of Endocrinology and Internal Medicine, Aarhus N, Denmark ;

Background: Reduced muscle strength is an acknowledged symptom of Graves' disease, but our knowledge on severity is sparse. We aimed to investigate muscle strength, balance, and muscle function in patients with Graves' disease compared to age- and gender-matched healthy controls.

Method: Using a cross sectional design, we compared 55 patients newly diagnosed with Graves' disease with 55 euthyroid controls, matched on sex, age, and menopausal status. Read More

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http://dx.doi.org/10.1089/thy.2018.0318DOI Listing
March 2019
1 Read

PROSTAGLANDIN F2-ALPHA EYE DROPS (BIMATOPROST) IN GRAVES' ORBITOPATHY: A RANDOMISED CONTROLLED DOUBLE MASKED CROSSOVER TRIAL (BIMA TRIAL).

Thyroid 2019 Mar 18. Epub 2019 Mar 18.

Cardiff University School of Medicine, 2111, Thyroid Research Group, Cardiff, Cardiff, United Kingdom of Great Britain and Northern Ireland ;

Background: Previous in vitro experiments have demonstrated that PGF2α reduced proliferation and adipogenesis in a murine cell line and human orbital fibroblasts derived from subjects with inactive Graves' orbitopathy (GO). The objective of this study was to determine if the PGF2α analogue Bimatoprost is effective at reducing proptosis in this population.

Methods: A randomized controlled double-masked crossover trial was conducted in a single tertiary care academic medical center. Read More

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http://dx.doi.org/10.1089/thy.2018.0506DOI Listing
March 2019
1 Read
4.493 Impact Factor

The relationships of surgeon volume and specialty with outcomes following pediatric thyroidectomy.

J Pediatr Surg 2019 Mar 1. Epub 2019 Mar 1.

Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:

Background: Previous studies of pediatric thyroidectomies suggest a volume-outcome relationship, but none have focused exclusively on pediatric surgical specialists. Our objective was to examine the effects of pediatric surgeon volume and specialty on post-thyroidectomy outcomes.

Methods: The Pediatric Health Information System was queried for patients ≤21 years who underwent partial or total thyroidectomy between 2005 and 2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.033DOI Listing
March 2019
1 Read

Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis.

JAMA Netw Open 2019 Mar 1;2(3):e190570. Epub 2019 Mar 1.

Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco.

Importance: Disability measures in multiple sclerosis (MS) fail to capture potentially important variability in walking behavior. More sensitive and ecologically valid outcome measures are needed to advance MS research.

Objectives: To assess continuous step count activity remotely among individuals with MS for 1 year and determine how average daily step count is associated with other measures of MS disability. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.0570DOI Listing
March 2019
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Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. Read More

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https://www.mdpi.com/2077-0383/8/3/347
Publisher Site
http://dx.doi.org/10.3390/jcm8030347DOI Listing
March 2019
4 Reads

MANAGEMENT OF THYROTOXICOSIS AMONG GENERAL PRACTITIONERS IN TRINIDAD COMPARED WITH 2016 AMERICAN THYROID ASSOCIATION GUIDELINES FOR HYPERTHYROIDISM.

Endocr Pract 2019 Mar 13. Epub 2019 Mar 13.

Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad.

OBJECTIVES A previous Trinidadian survey highlighted the investigative and therapeutic approaches selected by general practitioners (GPs) in managing thyrotoxicosis. The main objective of this study was to compare practice with existing guidelines. METHODS In this cross-sectional study a pretested de novo questionnaire was self-administered to GPs throughout Trinidad. Read More

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http://dx.doi.org/10.4158/EP-2018-0544DOI Listing
March 2019
1 Read

Electrosurgical debulking of pretibial myxedema of the foot.

Dermatol Online J 2019 Feb 15;25(2). Epub 2019 Feb 15.

Department of Dermatology, Mount Sinai Hospital, New York City, New York.

Pretibial myxedema or thyroid dermopathy constitutes dermal deposition of mucin, primarily hyaluronic acid and chondroitin sulfate. It is a manifestation of autoimmune thyroiditis, seen more in Graves disease than in Hashimoto thyroiditis. The time delay from treatment of hyperthyroidism to appearance of localized myxedema varies from one month to 16 years (mean 5. Read More

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February 2019
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Early Low Dose Rituximab for Active Thyroid Eye Disease: An Effective and Well Tolerated Treatment.

Clin Endocrinol (Oxf) 2019 Mar 13. Epub 2019 Mar 13.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease that can be disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long-term sequelae. Current management involves inflammation suppression using glucocorticoids. Read More

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http://doi.wiley.com/10.1111/cen.13970
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http://dx.doi.org/10.1111/cen.13970DOI Listing
March 2019
4 Reads

Evaluation of long-term follow-up and methimazole therapy outcomes of pediatric Graves' disease: a single-center experience.

J Pediatr Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Clinic of Pediatric Endocrinology, Altındağ/Ankara, Turkey.

Background The management options for Graves' disease in children are limited and there is controversy regarding optimal treatment. Remission rate with anti-thyroid drug (ATD) treatment in children is said to be lower than in adults. Definitive treatments are effective, but they often result in permanent hypothyroidism. Read More

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http://dx.doi.org/10.1515/jpem-2018-0495DOI Listing
March 2019
3 Reads

Long-term monitoring of Graves’ disease in children and adolescents: a single-center experience

Turk J Med Sci 2019 Mar 13;49(2). Epub 2019 Mar 13.

Background/aim: Graves’ disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism. Read More

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http://dx.doi.org/10.3906/sag-1804-177DOI Listing
March 2019
2 Reads

Investigation of Mixture Modelling Algorithms as a Tool for Determining the Statistical Likelihood of Serological Exposure to Filariasis Utilizing Historical Data from the Lymphatic Filariasis Surveillance Program in Vanuatu.

Trop Med Infect Dis 2019 Mar 8;4(1). Epub 2019 Mar 8.

College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4878, Australia.

As the prevalence of lymphatic filariasis declines, it becomes crucial to adequately eliminate residual areas of endemicity and implement surveillance. To this end, serological assays have been developed, including the Bm14 Filariasis CELISA which recommends a specific optical density cut-off level. We used mixture modelling to assess positive cut-offs of Bm14 serology in children in Vanuatu using historical OD (Optical Density) ELISA values collected from a transmission assessment survey (2005) and a targeted child survey (2008). Read More

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https://www.mdpi.com/2414-6366/4/1/45
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http://dx.doi.org/10.3390/tropicalmed4010045DOI Listing
March 2019
2 Reads

Technique and Results of Permanent Medial Tarsorrhaphy for Complex Eyelid Malposition.

Ophthalmic Plast Reconstr Surg 2019 Mar/Apr;35(2):197-201

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, U.S.A.

Purpose: To evaluate the results of permanent medial tarsorrhaphy and to describe the surgical technique.

Methods: Medial tarsorrhaphy was performed on 30 eyelids with symptomatic exposure keratopathy secondary to eyelid malposition. Observational, retrospective review of preoperative and postoperative examination findings was performed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001282DOI Listing
March 2019
3 Reads

Clinical Experience with Rituximab and Intravenous Immunoglobulin for Pretibial myxedema: A Case Series.

Thyroid 2019 Mar 11. Epub 2019 Mar 11.

Mayo Clinic Division of Endocrinology Diabetes Metabolism and Nutrition, 314193, Rochester, Minnesota, United States ;

Background: Severe pretibial myxedema (PTM) can be difficult to manage, highlighting the need to investigate newer therapies. Rituximab and intravenous immunoglobulin (IVIg) have been tried in Graves' orbitopathy. Since PTM and orbitopathy share a similar underlying pathophysiology, we aimed to explore these therapies for progressive PTM. Read More

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http://dx.doi.org/10.1089/thy.2018.0706DOI Listing
March 2019
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Papillary thyroid carcinoma in cervical lymph nodes with vanished thyroid gland after ablation of Graves' disease by radioactive iodine.

Ann R Coll Surg Engl 2019 Mar 11:e1-e3. Epub 2019 Mar 11.

Surgical Oncology Unit, Oncology Center Mansoura University , Mansoura , Egypt.

Primary thyroid carcinoma after thyroid ablation by radioactive iodine is rare. We present a very rare condition of lateral apparent papillary thyroid carcinoma eight years after receiving radioactive iodine for thyrotoxicosis, which led to complete anatomical and functional involution of the thyroid gland. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0033DOI Listing
March 2019
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Endothelial Cell Growth Promoting Activity in Graves' Disease Sera is Neutralized by Anti-Basic Fibroblast Growth Factor Antibodies in Patients with Fat Expansive but Not Infiltrative Orbitopathy.

Endocrinol Diabetes Metab J 2019 Feb 8;3(1). Epub 2019 Jan 8.

Division of Endocrinology, Harbor-UCLA Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Purpose: To report a case of orbital fat expansion leading to globe prolapse in a Graves' disease patient undergoing high-dose glucocorticoid therapy. To evaluate the growth factor receptor specificities of plasma autoantibodies in Graves' disease patients who exhibited contrasting subtypes of thyroid-associated ophthalmopathy, i.e. Read More

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February 2019
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Silent Progression in Disease Activity-Free Relapsing Multiple Sclerosis.

Ann Neurol 2019 Mar 9. Epub 2019 Mar 9.

UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143.

Objective: Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared to natural history studies from the pre-treatment era. Nonetheless, in our recently reported prospective cohort more than half of patients with relapsing MS accumulated significant new disability by the 10 year of follow-up. Notably, "no evidence of disease activity" at 2-years did not predict long-term stability. Read More

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http://doi.wiley.com/10.1002/ana.25463
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http://dx.doi.org/10.1002/ana.25463DOI Listing
March 2019
6 Reads

Multispectral optoacoustic tomography of benign and malignant thyroid disorders - a pilot study.

J Nucl Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Nuclear Medicine, University Hospital Münster, Germany, Germany.

This study aims at evaluating hybrid multispectral optoacoustic tomography (MSOT)/ultrasound for imaging of thyroid disorders, including Graves' disease and thyroid nodules. The functional biomarkers and tissue parameters deoxygenated (HbR), oxygenated (HbO2) and total hemoglobin (HbT), saturation of hemoglobin (sO2), fat and water content were analyzed in thyroid lobes affected by Graves' disease ( = 6), thyroid lobes with healthy thyroid tissue ( = 8), benign ( = 13) and malignant ( = 3) thyroid nodules. In Graves' disease, significantly higher values for HbR (3. Read More

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http://dx.doi.org/10.2967/jnumed.118.222174DOI Listing
March 2019
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[Pretibial myxoedema in Graves' disease].

Aten Primaria 2019 Mar 4. Epub 2019 Mar 4.

Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, España.

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http://dx.doi.org/10.1016/j.aprim.2018.08.013DOI Listing
March 2019
1 Read

Graves' disease as a first autoimmune manifestation of a stiff person syndrome.

Ann Endocrinol (Paris) 2019 Feb 14. Epub 2019 Feb 14.

Department of endocrinology and diabetology, CHU UCL Namur, Université Catholique de Louvain, rue Dr. Gaston Thérasse 1, 5530 Yvoir, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ando.2019.01.002DOI Listing
February 2019
1 Read

Glycosylation of thyroid-stimulating hormone receptor.

Endokrynol Pol 2019 ;70(1):86-100

Deptartment of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Krakow, Poland.

Thyroid-stimulating hormone receptor (TSHR) is a typical membrane receptor with 7-transmembrane helix domain (7TMR), coupled to the G protein. The mature receptor, present in the cell membrane, is composed of the A subunit comprising a large extracellular domain, and the B subunit, which consists of a short extracellular fragment anchored in the cell membrane and an intracellular part. The TSH receptor is subject to numerous post-translational modifications that determine its final structure and significantly affect its activity. Read More

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http://dx.doi.org/10.5603/EP.a2018.0077DOI Listing
January 2019
1 Read

Proteinuria in a patient with Graves' disease: Answers.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, 34098, Fatih, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-04221-xDOI Listing
March 2019
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Proteinuria in a patient with Graves' disease: Questions.

Pediatr Nephrol 2019 Mar 6. Epub 2019 Mar 6.

Department of Pediatric Endocrinology, Cerrahpasa Faculty of Medicine, Istanbul University- Cerrahpasa, 34098, Fatih, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-04220-yDOI Listing
March 2019
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Aberrant Expressions of Co-stimulatory and Co-inhibitory Molecules in Autoimmune Diseases.

Front Immunol 2019 20;10:261. Epub 2019 Feb 20.

Department of Endocrinology and Rheumatology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Co-signaling molecules include co-stimulatory and co-inhibitory molecules and play important roles in modulating immune responses. The roles of co-signaling molecules in autoimmune diseases have not been clearly defined. We assessed the expressions of co-stimulatory and co-inhibitory molecules in autoimmune diseases through a bioinformatics-based study. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391512PMC
February 2019

Evolution Strategies in Transaxillary Robotic Thyroidectomy: Considerations on the First 449 Cases Performed.

J Laparoendosc Adv Surg Tech A 2019 Mar 21. Epub 2019 Mar 21.

3 Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.

Background: In the past 20 years, the fast spread of new surgical technologies has reached an important peak with the advent of the robotic surgery. Many studies have been run about a cosmetic desire to avoid neck scars after thyroid surgery and this has led to the development of remote access robotic thyroidectomy (RT). Among the various RT approaches, unilateral transaxillary access is one of the most widely used, reporting excellent results in terms of feasibility and patient's compliance. Read More

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http://dx.doi.org/10.1089/lap.2019.0021DOI Listing
March 2019
2 Reads

Standardized Uptake Value Using Thyroid Quantitative SPECT/CT for the Diagnosis and Evaluation of Graves' Disease: A Prospective Multicenter Study.

Biomed Res Int 2019 30;2019:7589853. Epub 2019 Jan 30.

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.

The clinical applications of the quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) are being expanded to a variety of fields of nuclear medicine. However, clinical application of quantitative SPECT/CT for the evaluation of Graves' disease (GD) still needs further investigation. Our aim was to investigate the feasibility of standard uptake value (SUV) of the thyroid for the clinical diagnosis and evaluation of GD. Read More

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http://dx.doi.org/10.1155/2019/7589853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374828PMC
January 2019
5 Reads

Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study.

Lancet Diabetes Endocrinol 2019 Apr 28;7(4):278-287. Epub 2019 Feb 28.

Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, UK.

Background: Graves' disease is routinely treated with antithyroid drugs, radioiodine, or surgery, but whether the choice of initial therapy influences long-term outcomes is uncertain. We evaluated cardiovascular morbidity and mortality according to the method and effectiveness of primary therapy in Graves' disease.

Methods: In this retrospective cohort study, we identified patients with hyperthyroidism, diagnosed between Jan 1, 1998, and Dec 31, 2013, from a thyroid-stimulating hormone (TSH)-receptor antibody (TRAb) test register in south Wales, UK, and imported their clinical data into the All-Wales Secure Anonymised Information Linkage (SAIL) Databank (Swansea University, Swansea, UK). Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30059-2DOI Listing
April 2019
4 Reads

Can a patient-tailored treatment approach for Graves' disease reduce mortality?

Lancet Diabetes Endocrinol 2019 Apr 28;7(4):245-246. Epub 2019 Feb 28.

Department of Medicine and Surgery, University of Insubria, Varese, 21100 Italy.

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http://dx.doi.org/10.1016/S2213-8587(19)30057-9DOI Listing
April 2019
1 Read

Progressive stenosis and radiological findings of vasculitis over the entire internal carotid artery in moyamoya vasculopathy associated with graves' disease: a case report and review of the literature.

BMC Neurol 2019 Mar 2;19(1):34. Epub 2019 Mar 2.

Department of Neurology, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, Japan.

Background: Moyamoya vasculopathy (MMV) associated with Graves' disease (GD) is a rare condition resulting in ischemic stroke accompanied by thyrotoxicity. Radiological findings of vasculitis have been reported in the walls of distal internal carotid arteries (ICAs) in these patients; however, no reports have described in detail the processes of progression of the lesions in the proximal ICA. Moreover, treatments to prevent recurrence of ischemic stroke and progression of MMV have not yet been sufficiently elucidated. Read More

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http://dx.doi.org/10.1186/s12883-019-1262-1DOI Listing
March 2019
2 Reads

A Modifying Autoantigen in Graves' Disease.

Endocrinology 2019 Mar 1. Epub 2019 Mar 1.

Thyroid Research Unit, Icahn School of Medicine at Mount Sinai, New York, New York.

The TSH receptor (TSHR) is the major autoantigen in Graves' disease (GD). Bioinformatic analyses predicts the existence of several human TSHR isoforms from alternative splicing which can lead to the co-expression of multiple receptor forms of which the most abundant is TSHR-v1.3. Read More

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http://dx.doi.org/10.1210/en.2018-01048DOI Listing
March 2019
2 Reads

Characteristics and outcomes of patients with hyperthyroidism attending a hospital endocrine clinic-A retrospective study.

Endocrinol Diabetes Metab 2019 Jan 28;2(1):e00046. Epub 2018 Nov 28.

Poole Hospital, NHS Foundation Trust Poole UK.

Aims: A study looking at the distribution, management and outcomes of patients referred to a secondary care endocrine clinic with a diagnosis of hyperthyroidism.

Methods: Retrospective longitudinal study of 442 patients referred over a 15-year period (2002-2017) with a diagnosis of hyperthyroidism to a secondary care endocrine clinic. Information on demographics, diagnosis, treatments and outcomes was recorded as patients attended for clinic visits. Read More

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http://doi.wiley.com/10.1002/edm2.46
Publisher Site
http://dx.doi.org/10.1002/edm2.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354748PMC
January 2019
3 Reads

The value of total thyroidectomy as the definitive treatment for Graves' disease: A single centre experience of 594 cases.

J Clin Transl Endocrinol 2019 Jun 7;16:100183. Epub 2019 Feb 7.

University of Palermo, Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, Palermo, Italy.

Purpose: Thyroidectomy is the preferred approach as the definitive treatment for Graves' disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study.

Methods: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves' disease. Read More

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http://dx.doi.org/10.1016/j.jcte.2019.100183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377402PMC
June 2019
2 Reads

Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.

Ann Nutr Metab 2019 Feb 27;74(3):200-206. Epub 2019 Feb 27.

College of Medicine and Forensic, Health Science Center, Xi'an Jiao Tong University, Xi'an,

Some effective antithyroid drugs (ATDs) have been widely used for patients with Graves' disease (GD) but are associated with ATD-induced agranulocytosis. We selected 29 ATD-induced agranulocytosis patients, 44 ATD-induced neutropenia patients, and 140 GD controls among the Chinese Han population who were recruited at the First Affiliated Hospital of Xi'an Jiao Tong University. We assessed their response to ATDs treatment by performing genotyping for a candidate gene association study of samples from patients receiving treatment. Read More

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http://dx.doi.org/10.1159/000497314DOI Listing
February 2019
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Serum autotaxin levels are associated with Graves' disease.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the ATX/LPA axis in some immunological disturbances has been proposed. In this study, we investigated the association between serum ATX levels and Graves' disease. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0451DOI Listing
February 2019
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Inhibitory effects of methimazole and propylthiouracil on iodotyrosine deiodinase 1 in thyrocytes.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, Itabashi, Tokyo 173-8605, Japan.

Methimazole (MMI) and propylthiouracil (PTU) are commonly used for the treatment of Graves' disease. They share similar inhibitory effects on thyroid hormone biosynthesis by interfering with thyroid peroxidase (TPO)-mediated oxidation and organification of iodine. However, their potential effects on other thyroid functional molecules have not been explored in depth. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0380DOI Listing
February 2019

Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease.

Endocr J 2019 Feb 27. Epub 2019 Feb 27.

Institute of Anatomy and Anthropology, Riga Stradins University, Riga, LV-1010, Latvia.

T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1β in thyroid tissue. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0396DOI Listing
February 2019
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A case report of 131I therapy for Graves' disease patient with hemiagenesis.

Medicine (Baltimore) 2019 Feb;98(8):e14606

Department of Nuclear Medicine, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry.

Rationale: Thyroid hemiagenesis is a rare congenital dysplasia, whereas a variety of pathological changes may occur in residual thyroid lobe. The most frequently described pathology in residual thyroid lobe is Graves' hyperthyroidism. Although I therapy has been generally recommended as the preferred treatment for Graves' disease (GD), subjects relating to hemiagenesis are very limited, especially in China. Read More

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http://dx.doi.org/10.1097/MD.0000000000014606DOI Listing
February 2019
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What Is the Risk of Repeat Revision When Patellofemoral Replacement Is Revised to TKA? An Analysis of 482 Cases From a Large National Arthroplasty Registry.

Clin Orthop Relat Res 2018 Oct 30. Epub 2018 Oct 30.

P. L. Lewis, S. E. Graves, Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR), Adelaide, South Australia, Australia P. L. Lewis, Wakefield Orthopaedic Clinic, Adelaide, South Australia, Australia A. Cuthbert, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia D. Parker, Sydney Orthopaedic Research Institute, Chatswood, New South Wales, Australia P. Myers, Brisbane Orthopaedic & Sports Medicine Centre, Spring Hill, Queensland, Australia.

Background: Patellofemoral replacements (PFRs) have a higher rate of revision than unicompartmental knee arthroplasty or TKA. However, there is little information regarding why PFRs are revised, the components used for these revisions, or the outcome of the revision procedure. Some contend that PFR is a bridging procedure that can easily be revised to a TKA with similar results as a primary TKA; however, others dispute this suggestion. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000541DOI Listing
October 2018

Rare Co-occurrence of Ocular Myasthenia Gravis and Thyroid-Associated Orbitopathy (Ophthalmopathy) in an Individual With Hypothyroidism.

Front Endocrinol (Lausanne) 2018 12;9:801. Epub 2019 Feb 12.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Ocular myasthenia gravis (Ocular MG, OMG) shares many clinical features with thyroid-associated orbitopathy or thyroid-associated ophthalmopathy (TAO). In the rare instance of their coexistence, clinicians may fail to diagnose ocular MG when TAO is also present. Here we report the case of a patient with both TAO and ocular MG, whose "hyperthyroidism"-most likely the hashitoxicosis variant of Hashimoto's thyroiditis-rapidly transformed to hypothyroidism after radioactive iodine therapy. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2018.00801
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http://dx.doi.org/10.3389/fendo.2018.00801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379256PMC
February 2019
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Delayed Spine Pruning of Direct Pathway Spiny Projection Neurons in a Mouse Model of Parkinson's Disease.

Front Cell Neurosci 2019 12;13:32. Epub 2019 Feb 12.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

In animal models of Parkinson's disease (PD), principal striatal spiny projection neurons (SPNs) lose axospinous synapses. However, there has been a disagreement about whether this loss is restricted to a specific type of SPN or not, as some studies have reported pruning in both direct pathway SPNs and indirect pathway SPNs, while others have found this pruning to be restricted to indirect pathway SPNs. One possible explanation for the discrepancy is the period between the induction of the parkinsonian state and the assessment of spine loss. Read More

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http://dx.doi.org/10.3389/fncel.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379265PMC
February 2019

Multifactor Analysis of Thyroid Stiffness in Graves Disease: A Preliminary Study.

AJR Am J Roentgenol 2019 Feb 26:1-8. Epub 2019 Feb 26.

1 Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Rd, Guangzhou 510120, Guangdong Province, China.

Objective: The aim of this study was to evaluate the value of shear wave elastography (SWE) in Graves disease (GD) and to identify the potential factors influencing thyroid stiffness.

Materials And Methods: A total of 207 subjects were enrolled and underwent SWE examination in the study, including 162 patients with GD and 45 healthy volunteers with normal thyroids, matched for age and sex. For all subjects, five measurements of elastic modulus values (SWE mean, SWE minimum, and SWE maximum of a 9-mm ROI) were performed on each thyroid lobe, and a mean value was calculated. Read More

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http://dx.doi.org/10.2214/AJR.18.20414DOI Listing
February 2019
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A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Graves' Hyperthyroidism and Graves' Orbitopathy.

Eur Thyroid J 2019 Jan 13;8(1):7-15. Epub 2018 Dec 13.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Objective: Selenium (Se) supplementation has been suggested in the treatment of Graves' disease (GD). We sought to investigate Se prescription patterns for GD across European countries.

Methods: Members of the European Thyroid Association were invited to participate in an online survey investigating the use of Se in GD either without or with orbitopathy (GO). Read More

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http://dx.doi.org/10.1159/000494837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381891PMC
January 2019
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Clinical utility of TSH receptor antibody levels in Graves' orbitopathy: a comparison of two TSH receptor antibody immunoassays.

Cent Eur J Immunol 2018 31;43(4):405-412. Epub 2018 Dec 31.

Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Thyroid stimulating hormone (TSH) receptor antibodies (TRAB) play a role in the development of Graves' orbitopathy (GO), and measurements of the TRAB level may be helpful in monitoring GO treatment.

Aim Of The Study: To assess the correlation of TRAB levels measured with two different assays: third-generation TRAB assay (TRAB Cobas) and novel Immulite assay (TRAB Immulite), in patients with moderate-to-severe GO treated with intravenous glucocorticoid pulse therapy (ivGCs).

Material And Methods: Forty patients with active, moderate-to-severe GO underwent clinical and laboratory evaluation before, in the middle, and after ivGCs therapy. Read More

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http://dx.doi.org/10.5114/ceji.2018.80224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384424PMC
December 2018