115 results match your criteria Granulosa-Theca Cell Tumors


Active immunisation against GnRH as treatment for unilateral granulosa theca cell tumour in mares.

Equine Vet J 2021 Jul 2;53(4):740-745. Epub 2020 Oct 2.

Unit for Reproductive Medicine - Clinic for Horses, University of Veterinary Medicine, Hannover, Germany.

Background: Stallion-like or aggressive behaviour in mares affected by unilateral granulosa theca cell tumour (GTCT) is well-known, but use of a GnRH-vaccine as an alternative to surgical removal of the neoplastic ovary has not been investigated.

Objectives: To determine the effect of immunisation against GnRH on ovarian size, testosterone concentration, Anti-Müllerian hormone (AMH) concentration, and owner-reported behaviour in four mares affected by unilateral GTCT.

Study Design: Retrospective case report. Read More

View Article and Full-Text PDF

Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow.

Reprod Domest Anim 2019 Nov 17;54(11):1501-1504. Epub 2019 Sep 17.

Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

A Japanese Black cow was evaluated for prolonged post-partum anestrus and enlargement of the right ovary. Transrectal ultrasonography revealed that the right ovary was markedly enlarged and had a solid appearance, while the left ovary was small and inactive. The presumptive diagnosis was directed towards granulosa-theca cell tumour (GTCT) which was supported by markedly elevated plasma anti-Müllerian hormone (AMH; 332. Read More

View Article and Full-Text PDF
November 2019

Inhibin-A and inhibin-B in cyclic and pregnant mares, and mares with granulosa-theca cell tumors: Physiological and diagnostic implications.

Theriogenology 2018 Mar 7;108:192-200. Epub 2017 Dec 7.

Ansh Labs LLC, Webster, TX, USA.

Studies in mares have examined serum inhibin concentrations using immuno-assays unable to distinguish dimeric inhibin-A from inhibin-B isoforms. Inhibin-A and inhibin-B immuno-assays were used to investigate concentrations in cyclic mares, young and old (6 vs 19 years old, respectively) mares following hemi-ovariectomy, mares during pregnancy and in mares with confirmed granulosa cell tumors (GCTs). Mares with inter-ovulatory intervals of 26 days had ovulatory peaks of inhibin-A averaging 80 pg/mL with a mid-cycle nadir of 5 pg/mL. Read More

View Article and Full-Text PDF

FOXL2 Mutation Status in Granulosa Theca Cell Tumors of the Ovary.

Int J Gynecol Pathol 2017 Nov;36(6):568-574

Department of Pathology, University of California San Francisco, San Francisco (A.N., N.M.J., J.R., C.Z., K.G.) Department of Pathology, El Camino Hospital, Mountain View (A.R.S.), CA.

Ovarian sex-cord stromal tumors that have between 10% and 50% granulosa cells in a prominent fibrothecomatous background have been referred to as granulosa theca cell tumors or mixed granulosa theca cell tumors. The classification and prognosis of these tumors is not clear. Most adult granulosa cell tumors of the ovary harbor a mutation in the FOXL2 gene, whereas fibromas and thecomas lack this mutation. Read More

View Article and Full-Text PDF
November 2017

Evaluation of diagnostic utility, safety considerations, and effect on fertility of transvaginal ultrasound-guided ovarian biopsy in mares.

Theriogenology 2016 Apr 24;85(6):1030-6. Epub 2015 Nov 24.

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Ultrasound-guided biopsies of corpora lutea have been previously used for research purposes in the mare and cow. However, the health effects and fertility after transvaginal luteal biopsies (TVLB) or transvaginal ovarian biopsies (TVOB) obtained for diagnostic purposes in cases of suspected ovarian tumors have not been previously evaluated in the horse. The aim of this study was to determine the effects on health and fertility of TVLB and TVOB in mares; 53 mares were included in the study (11 control non-biopsied mares, 37 TVLB mares biopsied on one or more of the following Days 8, 10, 12, 15, 21, and 5 TVOB mares with ovarian abnormalities), resulting in a total of 108 TVLB and TVOB cycles and 183 procedures. Read More

View Article and Full-Text PDF

Management of Ovarian Cancer In Younger Women.

Rev Recent Clin Trials 2015 ;10(4):263-9

Department of Gynaec Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka State, India.

Background: Ovarian Cancer is a broad spectrum of diseases comprising several subtypes. Three major categories in younger women are germ cell tumor, sex cord stromal tumor and epithelial ovarian neoplasia.

Objective: literature search was for an update on management of ovarian cancer in young women. Read More

View Article and Full-Text PDF

Spontaneous lactogenesis and galactopoeisis in a virgin dairy heifer with evidence of a granulosa theca cell tumour.

Authors:
A J Gunn J Reader

N Z Vet J 2015 Nov 10;63(6):345-6. Epub 2015 Jul 10.

a School of Animal and Veterinary Science, and Graham Centre for Agricultural Innovation , Charles Sturt University , NSW 2678 , Australia.

View Article and Full-Text PDF
November 2015

Evidence of Spontaneous Recovery of Granulosa-Theca Cell Tumour in a Heifer: A Retrospective Report.

Reprod Domest Anim 2015 Aug 12;50(4):696-703. Epub 2015 Jun 12.

Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

A 14-month-old Japanese Black heifer was evaluated on Day 0 (D 0) for enlargement of the right ovary (RO). Transrectal ultrasonography (TRUS) revealed that the RO was markedly enlarged and multicystic, while the left ovary (LO) was small and inactive. The presumptive diagnosis was granulosa-theca cell tumour (GTCT), which was confirmed by markedly elevated plasma anti-Müllerian hormone (AMH) of 4. Read More

View Article and Full-Text PDF

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation.

J Ovarian Res 2014 Sep 6;7:88. Epub 2014 Sep 6.

Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable late recurrent and malignant behavior. Recent molecular studies have characterized the FOXL2 402C > G mutation in adult-type granulosa cell tumor. Read More

View Article and Full-Text PDF
September 2014

Plasma anti-Müllerian hormone as a biomarker for bovine granulosa-theca cell tumors: comparison with immunoreactive inhibin and ovarian steroid concentrations.

Theriogenology 2013 Nov 24;80(8):940-9. Epub 2013 Aug 24.

Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan; Department of Theriogenology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura 35516, Egypt.

Granulosa-theca cell tumors (GTCTs) are the most frequently reported ovarian tumors in cattle. Clinically, GTCTs could be confused with other ovarian abnormalities; therefore, the only definitive diagnosis for such tumors is histopathology of a biopsy from the affected ovary. However, this is an invasive technique and unsuitable for farm conditions. Read More

View Article and Full-Text PDF
November 2013

Long-term outcome for two heifers with a granulosa-theca cell tumour.

Vet Rec 2013 Jun 1;172(22):581. Epub 2013 May 1.

School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire CH64 7TE, UK.

View Article and Full-Text PDF

Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery.

N Z Vet J 2012 Mar;60(2):160-3

Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.

Case History: A 14-year-old Thoroughbred mare was presented for evaluation of a rapidly enlarging ovary at 73 days gestation. The mare's owner reported behavioural changes in the mare since she returned from stud, notably aggression towards other horses.

Clinical Findings: Transrectal palpation and ultrasonography of the reproductive tract revealed a viable pregnancy, an enlarged, multiloculated right ovary, and a normal-sized left ovary with a corpus luteum present. Read More

View Article and Full-Text PDF

Anti-Müllerian hormone profiles as a novel biomarker to diagnose granulosa-theca cell tumors in cattle.

J Reprod Dev 2012 4;58(1):98-104. Epub 2011 Nov 4.

Laboratory of Theriogenology, University of Miyazaki, Miyazaki 889-2192, Japan.

This study was carried out to evaluate the blood profile and tissue expression of Anti-Müllerian hormone (AMH) as a biomarker for granulosa-theca cell tumors (GTCTs) in cattle. Five cases with unilateral ovarian GTCTs (GTCT group) were investigated in comparison to other groups of Japanese Black cows, which had either cystic ovarian disease (COD group, n=5), a functional corpus luteum on Days 9 to 11 of the estrous cycle (Day 0=estrus; CL group, n=13) or received superovulation treatment (SOT group, n=13). We used transrectal ultrasonography and measured plasma AMH, estradiol-17β (E(2)), progesterone (P(4)) and testosterone (T) levels. Read More

View Article and Full-Text PDF

Two atypical cases of granulosa cell tumours in Belgian Blue heifers.

Reprod Domest Anim 2011 Aug 18;46(4):746-9. Epub 2010 Nov 18.

Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

This paper describes two atypical cases of granulosa cell tumours (GCTs) in Belgian Blue heifers. In the first case, an 18-month-old heifer died after ovariectomy, and a granulosa-theca cell tumour was diagnosed post-mortem. The second heifer (31 months of age) was near term and was successfully treated surgically for a malignant granulosa cell tumour. Read More

View Article and Full-Text PDF

Granulosa theca cell tumor with erythrocytosis in a llama.

Can Vet J 2010 Oct;51(10):1157-60

Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, 43210, USA.

A 2.5-year-old, female llama with weight loss and lethargy had a packed cell volume (PCV) of 45% which increased to 57% over 3 wk. Transrectal ultrasonography revealed a mass of mixed echogenicity involving the right ovary, which was removed. Read More

View Article and Full-Text PDF
October 2010

Cellular localization of androgen synthesis in equine granulosa-theca cell tumors: immunohistochemical expression of 17alpha-hydroxylase/17,20-lyase cytochrome P450.

Theriogenology 2010 Aug 22;74(3):393-401. Epub 2010 Apr 22.

Department of Population Health & Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Elevated blood testosterone concentrations, often accompanied by male-typical behaviors, is a common signalment of mares with granulosa-theca cell tumors (GCTCs), but no definitive information exists regarding the cellular differentiation of tumors associated with androgen secretion. This study was conducted to localize and thereby define the cellular expression of 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17), the enzyme most directly responsible for androgen synthesis, in 30 GTCTs and control tissues (gonads and adrenal glands) using immuno-histochemistry (IHC). Immuno-reactivity for P450c17 was evident in approximately half of 30 specimens examined, was most consistent in the interstitial cells surrounding existing or developing cysts, and was less intense in cells within cysts in the smaller proportion of specimens where this was observed. Read More

View Article and Full-Text PDF

Evaluation of a motorized morcellator for laparoscopic removal of granulosa-theca cell tumors in standing mares.

Vet Surg 2010 Jul 25;39(5):649-53. Epub 2010 Mar 25.

Equine Department, Section Surgery, Vetsuisse-Faculty, University of Zurich, CH-8057 Zurich, Switzerland.

Objective: To describe a motorized morcellator technique for laparoscopic removal of granulosa-theca cell tumors (GCT) in standing mares and to evaluate long-term outcome.

Study Design: Case series.

Animals: Mares (n=7) aged 4-15 years, with unilateral GCT. Read More

View Article and Full-Text PDF

Prenatal diagnosis of juvenile granulosa cell tumor of the testis.

J Pediatr Urol 2008 Dec 28;4(6):472-4. Epub 2008 Aug 28.

Doernbecher Children's Hospital, Oregon Health and Science University, Division of Urology, Department of Surgery, 3303 Southwest Bond Avenue, 10th Floor, Portland, OR 97239, USA.

Juvenile granulosa cell tumor is a rare benign neoplasm of the testicular stroma that accounts for 1-5% of all prepubertal testis tumors [Metcalfe PD, Farivar-Mohseni H, Farhat W, McLorie G, Khoury A, Bagli DJ. Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. J Urol 2003;170:2412-2416; Ross JH, Rybicki L, Kay R. Read More

View Article and Full-Text PDF
December 2008

Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome.

J Clin Endocrinol Metab 2008 May 19;93(5):1827-33. Epub 2008 Feb 19.

Department of Reproductive Medicine, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0633, USA.

Context: In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production.

Objective: The objective of this study was to determine whether FSH enhances androgen production in women with PCOS compared with that of normal women. Read More

View Article and Full-Text PDF

Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare.

Can Vet J 2007 May;48(5):502-5

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.

An Arabian mare was referred for right granulosa-theca cell tumor (GTCT) evaluation. The mare was presented 4.5 years later for a left GTCT, after successfully conceiving and delivering a normal foal in the interim. Read More

View Article and Full-Text PDF

A granulosa-theca cell tumour in a 15-month-old Thoroughbred filly.

Aust Vet J 2007 Mar;85(3):124-5

Goulburn Valley Equine Hospital, Congupna VIC 3633, Australia.

View Article and Full-Text PDF

Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden.

Fam Cancer 2007 ;6(1):35-41

Department of Oncology, Sahlgrenska University Hospital, S413 45 Göteborg, Sweden.

Aim: This study aimed to analyze whether the occurrence of both breast and ovarian cancer in a woman serves as a marker for BRCA gene mutations.

Material And Methods: This population-based study included 256 women in western Sweden who developed both invasive breast and ovarian tumors between 1958 and 1999. Archival paraffin tissue blocks of their tumors were retrieved for DNA-extraction to analyze the founder mutation, BRCA1 c. Read More

View Article and Full-Text PDF
September 2007

Gonadotropin secretion and pituitary responsiveness to GnRH in mares with granulosa-theca cell tumor.

Theriogenology 2006 Sep 2;66(5):1210-8. Epub 2006 May 2.

Department of Pathology, Diagnostic and Veterinary Clinic, Faculty of Veterinary Medicine, via S. Costanzo 4, 06126 Perugia, Italy.

Granulosa-theca cell tumors (GTCTs) are able to secrete variable amounts of sex steroids and immunoreactive inhibin (ir-INH). Although the pituitary appears to be affected by the presence of a GTCT, pituitary responsiveness to exogenous GnRH has not been examined. The aims of the present study were to: (i) assess the plasma hormone concentrations of ir-INH, gonadotropins and sex steroids in eight mares with GTCT and (ii) assess the responsiveness of pituitary gonadotroph cells to exogenous GnRH stimulus both before and after tumor removal. Read More

View Article and Full-Text PDF
September 2006

Diagnosis and surgical removal of a granulosa-theca cell tumor in a mare.

Authors:
Kathy T Maurice

Can Vet J 2005 Jul;46(7):644-6

Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

An 8-year-old mare showed stallion-like behavior and aggressiveness. A granulosa-theca cell tumor was tentatively diagnosed based on history, transrectal palpation, and ultrasonography, and surgically removed. Serological levels of testosterone and inhibin were elevated. Read More

View Article and Full-Text PDF

Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata).

J Med Primatol 2005 Aug;34(4):219-23

Primate Research center, National Institute of Immunology, New Delhi, India.

A mass was identified on the left caudal region of the abdomen in a 13-year-old bonnet monkey (Macaca radiata). The mass was excised and diagnosed as granulosa theca cell tumor accompanied with luteoma based on the microscopic findings. Morphologically it appeared pink, round, firm multilobulated measured approximately 5 x 3 x 2. Read More

View Article and Full-Text PDF

Metabolic changes in pelvic lesions: findings at proton MR spectroscopic imaging.

Gynecol Obstet Invest 2005 25;60(3):121-7. Epub 2005 May 25.

Department of Obstetrics and Gynecology, Inonu University Medical Faculty, Malatya, Turkey.

Objective: The purpose of this study is to investigate the in vivo magnetic resonance spectroscopic (MRS) features of pelvic lesions using long echo time and to characterize the spectral patterns of various pathological entities.

Materials And Methods: 17 patients with surgically and histopathologically confirmed pelvic lesions underwent long echo-time MRS, and the results obtained were analyzed. Before laparotomy, choline (Cho), lactate, lipid and creatine (Cr) levels of all lesions were measured by single voxel MRS (point-resolved spectroscopy technique, TE 136 ms). Read More

View Article and Full-Text PDF

Inhibin alpha and beta expression in ovarian stromal tumors and their histological equivalences.

Acta Obstet Gynecol Scand 2004 May;83(5):491-6

Department of Pathology, Ege University Medical Faculty, 35100 Bornova, Izmir, Turkey.

Inhibin is a heterodimeric protein hormone that appears to be a sensitive immunohistochemical marker of sex cord-stromal tumors. Although sex cord-stromal tumors can usually be distinguished from ovarian epithelial tumors or their metastases by morphology or by using antibodies against intermediate filaments, the diagnosis remains difficult in rare situations in such cases as sarcomatoid granulosa-theca cell tumors, ovarian small cell carcinomas, or soft-tissue sarcomas. The purposes of this study were to examine inhibin alpha and beta immunoreactivity in a wide range of gonadal stromal neoplasms and to assess its value in the differential diagnosis of problematic tumors. Read More

View Article and Full-Text PDF