112 results match your criteria Granulosa-Theca Cell Tumors


Inhibin-A and inhibin-B in cyclic and pregnant mares, and mares with granulosa-theca cell tumors: Physiological and diagnostic implications.

Theriogenology 2018 Mar 7;108:192-200. Epub 2017 Dec 7.

Ansh Labs LLC, Webster, TX, USA.

Studies in mares have examined serum inhibin concentrations using immuno-assays unable to distinguish dimeric inhibin-A from inhibin-B isoforms. Inhibin-A and inhibin-B immuno-assays were used to investigate concentrations in cyclic mares, young and old (6 vs 19 years old, respectively) mares following hemi-ovariectomy, mares during pregnancy and in mares with confirmed granulosa cell tumors (GCTs). Mares with inter-ovulatory intervals of 26 days had ovulatory peaks of inhibin-A averaging 80 pg/mL with a mid-cycle nadir of 5 pg/mL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X173058
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http://dx.doi.org/10.1016/j.theriogenology.2017.12.003DOI Listing
March 2018
5 Reads

FOXL2 Mutation Status in Granulosa Theca Cell Tumors of the Ovary.

Int J Gynecol Pathol 2017 Nov;36(6):568-574

Department of Pathology, University of California San Francisco, San Francisco (A.N., N.M.J., J.R., C.Z., K.G.) Department of Pathology, El Camino Hospital, Mountain View (A.R.S.), CA.

Ovarian sex-cord stromal tumors that have between 10% and 50% granulosa cells in a prominent fibrothecomatous background have been referred to as granulosa theca cell tumors or mixed granulosa theca cell tumors. The classification and prognosis of these tumors is not clear. Most adult granulosa cell tumors of the ovary harbor a mutation in the FOXL2 gene, whereas fibromas and thecomas lack this mutation. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000377DOI Listing
November 2017
46 Reads

Evaluation of diagnostic utility, safety considerations, and effect on fertility of transvaginal ultrasound-guided ovarian biopsy in mares.

Theriogenology 2016 Apr 24;85(6):1030-6. Epub 2015 Nov 24.

Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Ultrasound-guided biopsies of corpora lutea have been previously used for research purposes in the mare and cow. However, the health effects and fertility after transvaginal luteal biopsies (TVLB) or transvaginal ovarian biopsies (TVOB) obtained for diagnostic purposes in cases of suspected ovarian tumors have not been previously evaluated in the horse. The aim of this study was to determine the effects on health and fertility of TVLB and TVOB in mares; 53 mares were included in the study (11 control non-biopsied mares, 37 TVLB mares biopsied on one or more of the following Days 8, 10, 12, 15, 21, and 5 TVOB mares with ovarian abnormalities), resulting in a total of 108 TVLB and TVOB cycles and 183 procedures. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2015.11.013DOI Listing
April 2016
9 Reads

Management of Ovarian Cancer In Younger Women.

Rev Recent Clin Trials 2015 ;10(4):263-9

Department of Gynaec Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka State, India.

Background: Ovarian Cancer is a broad spectrum of diseases comprising several subtypes. Three major categories in younger women are germ cell tumor, sex cord stromal tumor and epithelial ovarian neoplasia.

Objective: literature search was for an update on management of ovarian cancer in young women. Read More

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August 2016
30 Reads

Spontaneous lactogenesis and galactopoeisis in a virgin dairy heifer with evidence of a granulosa theca cell tumour.

Authors:
A J Gunn J Reader

N Z Vet J 2015 Nov 10;63(6):345-6. Epub 2015 Jul 10.

a School of Animal and Veterinary Science, and Graham Centre for Agricultural Innovation , Charles Sturt University , NSW 2678 , Australia.

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http://dx.doi.org/10.1080/00480169.2015.1047912DOI Listing
November 2015
6 Reads

Evidence of Spontaneous Recovery of Granulosa-Theca Cell Tumour in a Heifer: A Retrospective Report.

Reprod Domest Anim 2015 Aug 12;50(4):696-703. Epub 2015 Jun 12.

Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

A 14-month-old Japanese Black heifer was evaluated on Day 0 (D 0) for enlargement of the right ovary (RO). Transrectal ultrasonography (TRUS) revealed that the RO was markedly enlarged and multicystic, while the left ovary (LO) was small and inactive. The presumptive diagnosis was granulosa-theca cell tumour (GTCT), which was confirmed by markedly elevated plasma anti-Müllerian hormone (AMH) of 4. Read More

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http://doi.wiley.com/10.1111/rda.12555
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http://dx.doi.org/10.1111/rda.12555DOI Listing
August 2015
10 Reads

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation.

J Ovarian Res 2014 Sep 6;7:88. Epub 2014 Sep 6.

Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable late recurrent and malignant behavior. Recent molecular studies have characterized the FOXL2 402C > G mutation in adult-type granulosa cell tumor. Read More

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http://dx.doi.org/10.1186/s13048-014-0088-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172858PMC
September 2014
14 Reads

Plasma anti-Müllerian hormone as a biomarker for bovine granulosa-theca cell tumors: comparison with immunoreactive inhibin and ovarian steroid concentrations.

Theriogenology 2013 Nov 24;80(8):940-9. Epub 2013 Aug 24.

Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan; Department of Theriogenology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura 35516, Egypt.

Granulosa-theca cell tumors (GTCTs) are the most frequently reported ovarian tumors in cattle. Clinically, GTCTs could be confused with other ovarian abnormalities; therefore, the only definitive diagnosis for such tumors is histopathology of a biopsy from the affected ovary. However, this is an invasive technique and unsuitable for farm conditions. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2013.07.022DOI Listing
November 2013
11 Reads

Long-term outcome for two heifers with a granulosa-theca cell tumour.

Vet Rec 2013 Jun 1;172(22):581. Epub 2013 May 1.

School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire CH64 7TE, UK.

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http://dx.doi.org/10.1136/vr.101399DOI Listing
June 2013
6 Reads

Granulosa theca cell tumour in a pregnant mare: concentrations of inhibin and testosterone in serum before and after surgery.

N Z Vet J 2012 Mar;60(2):160-3

Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.

Case History: A 14-year-old Thoroughbred mare was presented for evaluation of a rapidly enlarging ovary at 73 days gestation. The mare's owner reported behavioural changes in the mare since she returned from stud, notably aggression towards other horses.

Clinical Findings: Transrectal palpation and ultrasonography of the reproductive tract revealed a viable pregnancy, an enlarged, multiloculated right ovary, and a normal-sized left ovary with a corpus luteum present. Read More

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http://dx.doi.org/10.1080/00480169.2011.645776DOI Listing
March 2012
6 Reads

Anti-Müllerian hormone profiles as a novel biomarker to diagnose granulosa-theca cell tumors in cattle.

J Reprod Dev 2012 4;58(1):98-104. Epub 2011 Nov 4.

Laboratory of Theriogenology, University of Miyazaki, Miyazaki 889-2192, Japan.

This study was carried out to evaluate the blood profile and tissue expression of Anti-Müllerian hormone (AMH) as a biomarker for granulosa-theca cell tumors (GTCTs) in cattle. Five cases with unilateral ovarian GTCTs (GTCT group) were investigated in comparison to other groups of Japanese Black cows, which had either cystic ovarian disease (COD group, n=5), a functional corpus luteum on Days 9 to 11 of the estrous cycle (Day 0=estrus; CL group, n=13) or received superovulation treatment (SOT group, n=13). We used transrectal ultrasonography and measured plasma AMH, estradiol-17β (E(2)), progesterone (P(4)) and testosterone (T) levels. Read More

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July 2012
8 Reads

Two atypical cases of granulosa cell tumours in Belgian Blue heifers.

Reprod Domest Anim 2011 Aug 18;46(4):746-9. Epub 2010 Nov 18.

Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

This paper describes two atypical cases of granulosa cell tumours (GCTs) in Belgian Blue heifers. In the first case, an 18-month-old heifer died after ovariectomy, and a granulosa-theca cell tumour was diagnosed post-mortem. The second heifer (31 months of age) was near term and was successfully treated surgically for a malignant granulosa cell tumour. Read More

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http://doi.wiley.com/10.1111/j.1439-0531.2010.01717.x
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http://dx.doi.org/10.1111/j.1439-0531.2010.01717.xDOI Listing
August 2011
12 Reads

Granulosa theca cell tumor with erythrocytosis in a llama.

Can Vet J 2010 Oct;51(10):1157-60

Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, 43210, USA.

A 2.5-year-old, female llama with weight loss and lethargy had a packed cell volume (PCV) of 45% which increased to 57% over 3 wk. Transrectal ultrasonography revealed a mass of mixed echogenicity involving the right ovary, which was removed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942059PMC
October 2010
6 Reads

Cellular localization of androgen synthesis in equine granulosa-theca cell tumors: immunohistochemical expression of 17alpha-hydroxylase/17,20-lyase cytochrome P450.

Theriogenology 2010 Aug 22;74(3):393-401. Epub 2010 Apr 22.

Department of Population Health & Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Elevated blood testosterone concentrations, often accompanied by male-typical behaviors, is a common signalment of mares with granulosa-theca cell tumors (GCTCs), but no definitive information exists regarding the cellular differentiation of tumors associated with androgen secretion. This study was conducted to localize and thereby define the cellular expression of 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17), the enzyme most directly responsible for androgen synthesis, in 30 GTCTs and control tissues (gonads and adrenal glands) using immuno-histochemistry (IHC). Immuno-reactivity for P450c17 was evident in approximately half of 30 specimens examined, was most consistent in the interstitial cells surrounding existing or developing cysts, and was less intense in cells within cysts in the smaller proportion of specimens where this was observed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0093691X100013
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http://dx.doi.org/10.1016/j.theriogenology.2010.02.022DOI Listing
August 2010
6 Reads

Evaluation of a motorized morcellator for laparoscopic removal of granulosa-theca cell tumors in standing mares.

Vet Surg 2010 Jul 25;39(5):649-53. Epub 2010 Mar 25.

Equine Department, Section Surgery, Vetsuisse-Faculty, University of Zurich, CH-8057 Zurich, Switzerland.

Objective: To describe a motorized morcellator technique for laparoscopic removal of granulosa-theca cell tumors (GCT) in standing mares and to evaluate long-term outcome.

Study Design: Case series.

Animals: Mares (n=7) aged 4-15 years, with unilateral GCT. Read More

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http://doi.wiley.com/10.1111/j.1532-950X.2010.00688.x
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http://dx.doi.org/10.1111/j.1532-950X.2010.00688.xDOI Listing
July 2010
8 Reads

Prenatal diagnosis of juvenile granulosa cell tumor of the testis.

J Pediatr Urol 2008 Dec 28;4(6):472-4. Epub 2008 Aug 28.

Doernbecher Children's Hospital, Oregon Health and Science University, Division of Urology, Department of Surgery, 3303 Southwest Bond Avenue, 10th Floor, Portland, OR 97239, USA.

Juvenile granulosa cell tumor is a rare benign neoplasm of the testicular stroma that accounts for 1-5% of all prepubertal testis tumors [Metcalfe PD, Farivar-Mohseni H, Farhat W, McLorie G, Khoury A, Bagli DJ. Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. J Urol 2003;170:2412-2416; Ross JH, Rybicki L, Kay R. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S147751310800309
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http://dx.doi.org/10.1016/j.jpurol.2008.04.005DOI Listing
December 2008
12 Reads

Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome.

J Clin Endocrinol Metab 2008 May 19;93(5):1827-33. Epub 2008 Feb 19.

Department of Reproductive Medicine, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0633, USA.

Context: In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production.

Objective: The objective of this study was to determine whether FSH enhances androgen production in women with PCOS compared with that of normal women. Read More

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http://dx.doi.org/10.1210/jc.2007-2664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386684PMC
May 2008
6 Reads

Bilateral occurrence of granulosa-theca cell tumors in an Arabian mare.

Can Vet J 2007 May;48(5):502-5

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.

An Arabian mare was referred for right granulosa-theca cell tumor (GTCT) evaluation. The mare was presented 4.5 years later for a left GTCT, after successfully conceiving and delivering a normal foal in the interim. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852596PMC
May 2007
20 Reads

A granulosa-theca cell tumour in a 15-month-old Thoroughbred filly.

Aust Vet J 2007 Mar;85(3):124-5

Goulburn Valley Equine Hospital, Congupna VIC 3633, Australia.

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http://dx.doi.org/10.1111/j.1751-0813.2007.00110.xDOI Listing
March 2007
6 Reads

Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden.

Fam Cancer 2007 ;6(1):35-41

Department of Oncology, Sahlgrenska University Hospital, S413 45 Göteborg, Sweden.

Aim: This study aimed to analyze whether the occurrence of both breast and ovarian cancer in a woman serves as a marker for BRCA gene mutations.

Material And Methods: This population-based study included 256 women in western Sweden who developed both invasive breast and ovarian tumors between 1958 and 1999. Archival paraffin tissue blocks of their tumors were retrieved for DNA-extraction to analyze the founder mutation, BRCA1 c. Read More

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http://link.springer.com/10.1007/s10689-006-9101-0
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http://dx.doi.org/10.1007/s10689-006-9101-0DOI Listing
September 2007
9 Reads

Gonadotropin secretion and pituitary responsiveness to GnRH in mares with granulosa-theca cell tumor.

Theriogenology 2006 Sep 2;66(5):1210-8. Epub 2006 May 2.

Department of Pathology, Diagnostic and Veterinary Clinic, Faculty of Veterinary Medicine, via S. Costanzo 4, 06126 Perugia, Italy.

Granulosa-theca cell tumors (GTCTs) are able to secrete variable amounts of sex steroids and immunoreactive inhibin (ir-INH). Although the pituitary appears to be affected by the presence of a GTCT, pituitary responsiveness to exogenous GnRH has not been examined. The aims of the present study were to: (i) assess the plasma hormone concentrations of ir-INH, gonadotropins and sex steroids in eight mares with GTCT and (ii) assess the responsiveness of pituitary gonadotroph cells to exogenous GnRH stimulus both before and after tumor removal. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2006.03.030DOI Listing
September 2006
12 Reads

Diagnosis and surgical removal of a granulosa-theca cell tumor in a mare.

Authors:
Kathy T Maurice

Can Vet J 2005 Jul;46(7):644-6

Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.

An 8-year-old mare showed stallion-like behavior and aggressiveness. A granulosa-theca cell tumor was tentatively diagnosed based on history, transrectal palpation, and ultrasonography, and surgically removed. Serological levels of testosterone and inhibin were elevated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168883PMC
July 2005
8 Reads

Granulosa theca cell tumor with luteoma in the ovary of a bonnet monkey (Macaca radiata).

J Med Primatol 2005 Aug;34(4):219-23

Primate Research center, National Institute of Immunology, New Delhi, India.

A mass was identified on the left caudal region of the abdomen in a 13-year-old bonnet monkey (Macaca radiata). The mass was excised and diagnosed as granulosa theca cell tumor accompanied with luteoma based on the microscopic findings. Morphologically it appeared pink, round, firm multilobulated measured approximately 5 x 3 x 2. Read More

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http://doi.wiley.com/10.1111/j.1600-0684.2005.00108.x
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http://dx.doi.org/10.1111/j.1600-0684.2005.00108.xDOI Listing
August 2005
10 Reads

Metabolic changes in pelvic lesions: findings at proton MR spectroscopic imaging.

Gynecol Obstet Invest 2005 25;60(3):121-7. Epub 2005 May 25.

Department of Obstetrics and Gynecology, Inonu University Medical Faculty, Malatya, Turkey.

Objective: The purpose of this study is to investigate the in vivo magnetic resonance spectroscopic (MRS) features of pelvic lesions using long echo time and to characterize the spectral patterns of various pathological entities.

Materials And Methods: 17 patients with surgically and histopathologically confirmed pelvic lesions underwent long echo-time MRS, and the results obtained were analyzed. Before laparotomy, choline (Cho), lactate, lipid and creatine (Cr) levels of all lesions were measured by single voxel MRS (point-resolved spectroscopy technique, TE 136 ms). Read More

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http://dx.doi.org/10.1159/000086003DOI Listing
May 2006
8 Reads

Inhibin alpha and beta expression in ovarian stromal tumors and their histological equivalences.

Acta Obstet Gynecol Scand 2004 May;83(5):491-6

Department of Pathology, Ege University Medical Faculty, 35100 Bornova, Izmir, Turkey.

Inhibin is a heterodimeric protein hormone that appears to be a sensitive immunohistochemical marker of sex cord-stromal tumors. Although sex cord-stromal tumors can usually be distinguished from ovarian epithelial tumors or their metastases by morphology or by using antibodies against intermediate filaments, the diagnosis remains difficult in rare situations in such cases as sarcomatoid granulosa-theca cell tumors, ovarian small cell carcinomas, or soft-tissue sarcomas. The purposes of this study were to examine inhibin alpha and beta immunoreactivity in a wide range of gonadal stromal neoplasms and to assess its value in the differential diagnosis of problematic tumors. Read More

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http://doi.wiley.com/10.1111/j.0001-6349.2004.00167.x
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http://dx.doi.org/10.1111/j.0001-6349.2004.00167.xDOI Listing
May 2004
9 Reads

Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas.

Gynecol Oncol 2004 Mar;92(3):761-8

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA.

Objective: To determine the temporal and spatial expression of interleukins (IL)-13 and IL-15 in ovarian carcinoma compared to normal ovarian tissue.

Methods: Quantitative RT-PCR, ELISA and immunohistochemistry.

Results: Q-RT-PCR, ELISA and immunohistochemical analysis indicates that IL-13 and IL-15 mRNA and protein are expressed in normal ovary at various phases of the menstrual cycle with immunoreactive proteins detected in granulosa/theca and luteal cells and to a lesser extent in stromal cells and surface epithelial cells. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S009082580300878
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http://dx.doi.org/10.1016/j.ygyno.2003.12.011DOI Listing
March 2004
5 Reads

[Enlarged ovary in a mare: review of the literature and a case report].

Tijdschr Diergeneeskd 2003 Nov;128(22):692-6

Hoofdafdeling Gezondheidszorg Paard, discipline Inwendige Ziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht, Yalelaan 16, 3584 CM Utrecht.

Mares regularly have an enlarged ovary. The main causes are haematomas, anovulatory follicles, abscesses, and neoplasia. The granulosa-theca-cell tumour is by far the most common neoplasia of the ovary (about 97%) and accounts for 2. Read More

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November 2003
7 Reads

Endocrinological changes before and after removal of the granulosa theca cell tumor (GTCT) affected ovary in 6 mares.

J Vet Med Sci 2003 Aug;65(8):887-91

Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.

To clarify the endocrinological characteristics of the mares with granulosa theca cell tumor (GTCT), peripheral plasma samples from the 6 mares affected with GTCT were collected before and after the surgical removal of the affected ovary. Concentrations of testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), immunoreactive-inhibin (ir-INH), progesterone (P) and estradiol-17beta (E(2)) in the plasma samples were measured by radioimmunoassay. Before removal of GTCT in all cases, the concentrations of T were significantly higher than those of normal mares at the breeding and non-breeding seasons, whereas plasma concentrations of FSH, LH, ir-INH, P and E(2) were lower. Read More

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August 2003
7 Reads

Spontaneous repair of the atrophic contralateral ovary without ovariectomy in the case of a granulosa theca cell tumor (GTCT) affected mare.

J Vet Med Sci 2003 Jun;65(6):749-51

Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.

A 21 year old thoroughbred mare with granulosa theca cell tumor (GTCT) in the right side and atrophic contralateral ovary was investigated in this study. After arrival at our laboratory on 10th December 1999, the clinical diagnosis of GTCT was examined by rectal palpation and ultrasonographic image of ovaries. Plasma from peripheral blood was collected in the breeding and non-breeding seasons for hormonal analysis. Read More

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June 2003
5 Reads

Localization of inhibin alpha-, betaA- and betaB-subunits and aromatase in ovarian follicles with granulosa theca cell tumor (GTCT) in 6 mares.

J Vet Med Sci 2003 Jun;65(6):713-7

Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan.

To clarify the morphological and immunohistochemical characteristics in mares with granulosa theca cell tumor (GTCT), the localization of inhibin subunits (alpha, betaA, betaB) and aromatase in the granulosa cell layers and theca layers in the ovarian follicles were determined by immunohistochemical staining. The follicles were obtained from the ovaries of 6 mares with GTCT and 4 normal mares as controls. Immunohistochemically, inhibin alpha-subunit was localized in the granulosa cells of all follicles showing different sizes in all GTCT cases and betaA- subunit was localized in two GTCT cases in all sized follicles. Read More

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June 2003
6 Reads

Juvenile granulosa-theca cell (sex cord-stromal) tumor of the infant testis.

J Urol 2003 Apr;169(4):1497-8

Department of Urology, Indiana University School of Medicine and Riley Children's Hospital, Indianapolis, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002253470563803
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http://dx.doi.org/10.1097/01.ju.0000055782.62956.0fDOI Listing
April 2003
7 Reads

Malignant granulosa-theca cell tumor in a two-year-old Miniature Horse.

J Vet Diagn Invest 2003 Jan;15(1):60-3

Department of Pathobiology and Diagnostic Investigation/Animal Health Diagnostic Laboratory, Michigan State University College of Veterinary Medicine, G300 Veterinary Medical Center, East Lansing, MI 48824, USA.

A 2-year-old female Miniature Horse that presented with a history of progressive weight loss, depression, and diarrhea was diagnosed at necropsy with a highly malignant abdominal neoplasm involving the left ovary, kidneys, adrenal glands, intestines, and various abdominal and thoracic lymph nodes. Microscopic examination of these masses revealed large pleomorphic cells that stained positive for vimentin and inhibin and negative for epithelial membrane antigen and placental alkaline phosphatase. Ultrastructural examination of the cells revealed a high nucleocytoplasmic ratio and indented euchromatic nuclei with large nucleoli. Read More

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http://dx.doi.org/10.1177/104063870301500114DOI Listing
January 2003
5 Reads

[Case report of a granulosa-theca tumor in a cow].

Tijdschr Diergeneeskd 2002 May;127(9):286-8

Afdeling Gezondheidszorg Herkauwers, Faculteit der Diergeneeskunde, Universiteit Utrecht, Postbus 80151, 3508 TD Utrecht.

A 2 year-old cow with abnormal behaviour was observed during a farm visit. Rectal palpation of the cow revealed the presence of a mass of at least 12 cm in diameter. After further examination, it appeared that 'ovarian tumour' was the most likely differential diagnosis. Read More

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May 2002
4 Reads

Detection of high circulating concentrations of inhibin pro- and -alphaC immunoreactivity in mares with granulosa-theca cell tumours.

Equine Vet J 2002 Mar;34(2):203-6

Department of Veterinary Clinical Studies, University of Edinburgh and School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK.

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March 2002
8 Reads

Life-threatening haemoptysis presenting as a late complication of an ovarian tumour.

Int J Clin Pract 2001 Dec;55(10):729-30

The Prince Charles Hospital, Brisbane, Queensland, Australia.

Massive haemoptysis may arise as a result of lung malignancy. This case represents the first report of an ovarian granulosa cell tumour metastasising many years after initial tumour resection to the lung causing life-threatening haemoptysis. The management and subsequent clinical course of the patient are discussed as well as the natural history of granulosa-theca cell tumours. Read More

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December 2001
5 Reads

Cisplatin (P), vinblastine (V) and bleomycin (B) combination chemotherapy in recurrent or advanced granulosa(-theca) cell tumours of the ovary. An EORTC Gynaecological Cancer Cooperative Group study.

Eur J Cancer 1999 Sep;35(9):1331-7

Department of Gynaecology, University of Brescia, Italy.

The aim of this study was to investigate the clinical activity and toxicity of a modified PVB regimen (cisplatin, vinblastine and bleomycin) in patients with advanced or recurrent, pure granulosa cell tumours (GCTs) or mixed granulosa-theca cell tumours (GTCTs). The PVB regimen consisted of cisplatin (P) 20 mg/m2 intravenous (i.v. Read More

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September 1999
7 Reads

Inhibin localization in equine granulosa-theca cell tumours and inhibin forms in tumour fluid.

J Reprod Fertil Suppl 2000 (56):247-55

Departments of Animal Science, University of Minnesota, St. Paul, MN 55108, USA.

The aim of this study was to examine inhibin production in granulosa-theca cell tumours (GTCT). The experimental aims were: (i) to determine GTCT cell types that produce inhibin alpha- and betaA-subunits; (ii) to determine whether alpha- and betaA-subunit forms differ in GTCT fluid and normal equine follicular fluid (eFF); and (iii) to determine whether dimeric inhibin (alpha betaA) is present in GTCT plasma and tumour fluid. Plasma, tumour fluid and tumour tissue were collected from mares (n=6) with GTCT. Read More

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July 2011
8 Reads

Dimeric inhibin concentrations in mares with granulosa-theca cell tumors.

Am J Vet Res 1999 Nov;60(11):1407-10

Department of Animal Science, University of Minnesota, St Paul 55108, USA.

Objective: To determine whether concentrations of dimeric inhibin (CaCA) are greater in plasma and tumor fluid from mares with granulosa-theca cell tumors (GTCT), compared with concentrations in plasma and equine follicular fluid (eFF) from control mares.

Animals: 6 mares with GTCT and 12 clinically normal mares.

Procedure: The alphabetaA immunoradiometric assay used 2 antibodies, one against each subunit of inhibin (alpha and betaA subunits). Read More

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November 1999
7 Reads

Granulosa-theca cell tumour of the ovaries. A late metastasizing tumour.

West Indian Med J 1999 Mar;48(1):33-5

Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica.

Granulosa-theca cell tumours are ovarian neoplasms of low malignancy with hormone secreting potential, accounting for 2-3% of all ovarian cancers. They have an uncertain clinical course and a potential for late recurrence after surgical removal. Clinical features of a patient presenting with pulmonary metastases 21 years after removal of the primary tumour are described, along with a review of the management options. Read More

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March 1999
7 Reads

Review of the granulosa-theca cell tumors from the emil Novak ovarian tumor registry.

Am J Obstet Gynecol 1999 Feb;180(2 Pt 1):323-7

Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, Baltimore, MD, USA.

Objective: Our purpose was to review patients with granulosa and theca cell tumors as filed in the Emil Novak Ovarian Tumor Registry.

Study Design: Our study was a descriptive, retrospective study of 454 case records.

Results: The reviewed diagnoses were for 97 patients with granulosa cell tumors, 116 with theca cell tumors, and 97 with granulosa-theca cell tumors. Read More

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February 1999
6 Reads

Gynandroblastoma in pregnancy: case report and review of literature.

Authors:
T Kalir F Friedman

Mt Sinai J Med 1998 Sep;65(4):292-5

Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Gynandroblastoma is an extremely rare tumor, composed of sex cord and stromal cells of both ovarian (granulosa-theca) and testicular (Sertoli-Leydig) types. We believe that its occurrence during pregnancy has not been previously reported. The patient was a 32-year-old woman who during her pregnancy was noted to have a progressively enlarging, unilocular left ovarian cyst. Read More

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September 1998
4 Reads

Direct luteinizing hormone action triggers adrenocortical tumorigenesis in castrated mice transgenic for the murine inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.

Mol Endocrinol 1998 Jun;12(6):801-9

Department of Physiology, University of Turku, Finland.

Transgenic (TG) mice, expressing the Simian Virus 40 T-antigen (Tag) under a 6-kb fragment of the murine inhibin alpha-subunit promoter (inh alpha p), develop gonadal tumors of granulosa/theca or Leydig cell origin. We showed previously that adrenocortical tumors develop if the TG mice are gonadectomized but never develop in intact animals. However, if functional gonadectomy was induced by GnRH antagonist treatment or by cross-breeding the TG mice into the hypogonadotropic hpg genetic background, neither gonadal nor adrenal tumors appeared. Read More

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http://dx.doi.org/10.1210/mend.12.6.0117DOI Listing
June 1998
4 Reads

Regression of subcutaneous lymphoma following removal of an ovarian granulosatheca cell tumor in a horse.

J Am Vet Med Assoc 1998 May;212(9):1419-22

Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0125, USA.

A 9-year-old Arabian mare was admitted for evaluation of multiple subcutaneous nodules and infertility. Fine-needle aspiration of one of the subcutaneous nodules resulted in a cytologic diagnosis of histiolymphocytic lymphoma. Palpation per rectum and transrectal ultrasonography revealed a mass associated with the left ovary. Read More

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May 1998
7 Reads

Granulosa and theca cell tumors in children: a report of 17 cases and literature review.

Obstet Gynecol Surv 1998 Apr;53(4):240-7

Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, Maryland, USA.

The files of the Emil Novak Ovarian Tumor Registry (ENOTR) were searched for granulosa and theca cell tumors in children aged 12 years and less. In addition, an extensive literature search was done for English publications on children with these tumors aged 10 years or less. Of the 17 children from the ENOTR, 5 had adult-type granulosa cell tumors, 6 had juvenile granulosa cell tumors, and 1 had a luteinized granulosa cell tumor. Read More

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April 1998
5 Reads

Ovarian torsion associated with granulosa-theca cell tumor in a mare.

J Am Vet Med Assoc 1997 Nov;211(9):1152-4

Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.

A 12-year-old Morgan mare was examined because of stallion-like behavior of 45 days' duration. Palpation per rectum and transrectal ultrasonographic examination revealed a large left ovary with multiple cystic areas and crepitus. A granulosa-theca cell tumor was suspected. Read More

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November 1997
4 Reads

Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene.

Endocrinology 1997 Aug;138(8):3521-31

Department of Physiology, University of Turku, Finland.

We have previously developed a transgenic (TG) mouse model expressing the Simian virus 40 T-antigen (Tag), driven by a 6-kb fragment of the mouse inhibin alpha-subunit promoter (inh-alpha). The mice develop metastasizing gonadal tumors, of granulosa/theca or Leydig cell origin, with 100% penetrance by the age of 5-8 months. In the present study, we examined whether the appearance and growth of the gonadal tumors are dependent on gonadotropins. Read More

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http://dx.doi.org/10.1210/endo.138.8.5316DOI Listing
August 1997
7 Reads

Alpha and beta subunits of inhibin/activin as sex cord-stromal differentiation markers.

Int J Gynecol Pathol 1997 Jul;16(3):263-71

Department of Pathology, Women and Infants' Hospital, Brown University, Providence, Rhode Island, USA.

Inhibins (alpha and beta heterodimers) and activins (beta homodimers) are related peptides with opposing biologic action on gonadotropin regulation. They serve as components of the pituitary-gonadal feedback system. Although sex-cord stromal tumors can usually be distinguished from ovarian epithelial tumors or their metastases by morphology or by using antibodies against intermediate filaments, the diagnosis remains difficult in rare situations in such cases as sarcomatoid granulosa-theca cell tumors, ovarian small cell carcinomas, or soft-tissue sarcomas. Read More

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July 1997
7 Reads

Some observations on naturally occurring neoplasms of domestic fowls in the State of Victoria, Australia (1977-87).

Authors:
R L Reece

Avian Pathol 1996 Sep;25(3):407-47

Department of Agriculture and Rural Affairs, Veterinary Research Institute, Parkville, Victoria, Australia.

In the 10 years to November 1987, 33 different types of naturally occurring neoplasms were diagnosed in 2281 domestic fowls submitted for necropsy examination. The most prevalent type was lymphoma (1825/2281 = 80%) including two cases in chickens from a flock free from Marek's disease virus, exogenous avian leukosis viruses and reticuloendotheliosis virus; the remaining lymphomas were diagnosed on gross and/or histological criteria as Marek's disease (1069) or lymphoid leukosis (754). Of the non-lymphoid neoplasms, leiomyomas of the ventral ligament of the oviduct (99) were the most common followed closely by metastatic abdominal adenocarcinomas (93) and haemangiomas or haemangiosarcomas (91). Read More

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http://www.tandfonline.com/doi/full/10.1080/0307945960841915
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http://dx.doi.org/10.1080/03079459608419153DOI Listing
September 1996
8 Reads