223 results match your criteria Granulomatous Diseases of the Head and Neck


Head and Neck Manifestations of Granulomatosis with Polyangiitis: A Retrospective analysis of 19 Patients and Review of the Literature.

Int Arch Otorhinolaryngol 2019 Apr 1;23(2):165-171. Epub 2019 Mar 1.

Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain.

Granulomatosis with Polyangiitis (GPA) is a small vessel vasculitis characterized by a necrositing granulomatous inflammation of the upper and lower respiratory tracts and focal/proliferative glomerulonephritis. In more than 70% of the cases, the presenting symptoms are head and neck manifestations that are often misdiagnosed as infectious or allergic in etiology.  The present study provides an analysis of head and neck manifestations in a series of patients diagnosed with GPA. Read More

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http://dx.doi.org/10.1055/s-0038-1675759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449134PMC
April 2019
1 Read

Chronic non-granulomatous supraglottitis of a male adolescent and its successful management with azathioprine.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Ear, Nose and Throat Surgery, Monash Health, Clayton, Victoria, Australia.

Chronic non-granulomatous supraglottitis (CNGS) is a rare disorder of the supraglottic larynx, characterised by chronic supraglottic inflammation in the absence of granulomata, vasculitis, neoplasia, autoimmune disease or infective changes on histology. We present the case of a male adolescentwho attended with progressively worsening exertional dyspnoea, stridor and symptoms of obstructive sleep apnoea. Flexible nasendoscopy revealed marked supraglottic subepithelial thickening sparing the glottis and subglottis, confirmed on microlaryngoscopy. Read More

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http://dx.doi.org/10.1136/bcr-2018-227458DOI Listing
April 2019
2 Reads

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler.

Laryngoscope 2019 Mar 26. Epub 2019 Mar 26.

Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58-year-old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Read More

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http://dx.doi.org/10.1002/lary.27952DOI Listing
March 2019
3 Reads

Sarcoidosis of the paranasal sinuses.

Eur Arch Otorhinolaryngol 2019 Mar 21. Epub 2019 Mar 21.

Department of Otorhinolaryngology, Munich University (LMU), Munich, Germany.

Background: Sarcoidosis is a chronic disease, which predominantly affects the lung. Since sinonasal sarcoidosis is rare, little is known about the sarcoidosis manifestation at this site. Therefore, the aim of our study was to detect the prevalence of sinonasal sarcoidosis, its clinical occurrence, diagnosis, and therapy. Read More

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http://dx.doi.org/10.1007/s00405-019-05388-7DOI Listing
March 2019
4 Reads

Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence.

Laryngoscope 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, Georgia.

A review of the treatment of allergic and invasive fungal sinusitis, as well as a presentation of the first recorded case of a conversion from allergic fungal sinusitis (AFS) to chronic granulomatous invasive sinusitis and the fourth case of invasive fungal sinusitis associated with Curvularia. This immunocompetent patient suffering from chronic AFS converted after repeated high-dose steroid tapers and noncompliance. AFS may present atypically and should be suspected even in immunocompetent patients with sinus disease who report new onset pain and neurologic symptoms. Read More

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http://doi.wiley.com/10.1002/lary.27884
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http://dx.doi.org/10.1002/lary.27884DOI Listing
March 2019
6 Reads

An Unusual Case of Tertiary Syphilis Behaving Like Tongue Squamous Cell Carcinoma.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820355. Epub 2018 Dec 20.

Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, CA, USA.

Syphilis may present with a myriad of oral manifestations in the primary, secondary, and tertiary stages, and may be confused with malignancy. Despite a rise in the incidence of syphilis, tertiary syphilis is exceedingly rare. Tertiary syphilis gummas usually affect the hard palate, while tongue involvement is very rare. Read More

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http://dx.doi.org/10.1177/2324709618820355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302270PMC
December 2018

Magnetic resonance perfusion and diffusion characteristics of granulomatous diseases mimic those of malignant lesions: six case reports.

Oral Radiol 2018 Jan 16;34(1):73-82. Epub 2017 Mar 16.

Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki, 852-8588, Japan.

The perfusion and diffusion properties of a tumor are important clues in evaluating its growth potential and predicting its histological type, such as benign or malignant. Tumor perfusion can be estimated by assessing time-dependent changes in the intratumoral levels of the contrast agent during dynamic contrast-enhanced magnetic resonance (MR) imaging, whereas tumor diffusion can be estimated by assessing intratumoral water diffusivity on diffusion-weighted MR imaging. Granulomatous diseases with different etiologies occur in various head and neck regions, including the mandible, maxillary sinus, salivary glands, and lymph nodes. Read More

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http://dx.doi.org/10.1007/s11282-017-0271-2DOI Listing
January 2018
1 Read

Neurosarcoidosis As a Rare Differential Diagnosis for Single Or Multiple Lesions of the Nervous System.

Br J Neurosurg 2018 Oct 8:1-5. Epub 2018 Oct 8.

d Department of Otorhinolaryngology, Head and Neck Surgery , University of Bonn , Bonn , Germany.

Objective: Sarcoidosis is a multisystemic granulomatous disease of unknown cause which affects the lung or bilateral hilar lymphadenopathy in over 90% of the cases. Neurosarcoidosis (NS) is rare and accounts for approximately 5 - 15% of the cases. Involvement of all parts of the central and peripheral nervous system is possible with various clinical symptoms, e. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2018.1
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http://dx.doi.org/10.1080/02688697.2018.1506094DOI Listing
October 2018
6 Reads

Emerging and re-emerging infectious disease in otorhinolaryngology.

Acta Otorhinolaryngol Ital 2018 Apr;38(SUPPL. 1):S1-S106

SOC Neuroanestesia e Rianimazione, A.O.U. Careggi, Firenze, Italy.

Summary: Emerging and re-emerging infectious disease in otorhinolaryngology (ENT) are an area of growing epidemiological and clinical interest. The aim of this section is to comprehensively report on the epidemiology of key infectious disease in otorhinolaryngology, reporting on their burden at the national and international level, expanding of the need of promoting and implementing preventive interventions, and the rationale of applying evidence-based, effective and cost- effective diagnostic, curative and preventive approaches. In particular, we focus on i) ENT viral infections (HIV, Epstein-Barr virus, Human Papilloma virus), retrieving the available evidence on their oncogenic potential; ii) typical and atypical mycobacteria infections; iii) non-specific granulomatous lymphadenopathy; iv) emerging paediatric ENT infectious diseases and the prevention of their complications; v) the growing burden of antimicrobial resistance in ENT and the strategies for its control in different clinical settings. Read More

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http://www.actaitalica.it/issues/2018/2-2018S1/Suppl._Relazi
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056203PMC
http://dx.doi.org/10.14639/0392-100X-suppl.1-38-2018DOI Listing
April 2018
3 Reads

Suprabasal acantholytic dermatologic toxicities associated checkpoint inhibitor therapy: A spectrum of immune reactions from paraneoplastic pemphigus-like to Grover-like lesions.

J Cutan Pathol 2018 Oct 24;45(10):764-773. Epub 2018 Jul 24.

Section of Dermatopathology, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Checkpoint inhibitors (CPIs) restore the function of effector immunocytes to target and destroy cancer cells. Immune-related adverse events (irAEs) are a consequence of immune reactivation, with unpredictable inflammatory response, loss of self-tolerance, and development of autoimmunity. Adverse events from CPIs that present as dermatologic toxicities have diverse clinical and histopathologic features. Read More

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http://dx.doi.org/10.1111/cup.13312DOI Listing
October 2018
36 Reads

Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion.

Acta Stomatol Croat 2017 Dec;51(4):326-331

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Introduction: The aim of this case report was to discuss an extremely rare oral lesion as a result of primary pulmonary tuberculosis.

Case Report: In this case report, the patient with refractory painless ulceration at ventral surface of the tongue was described. Detailed medical history was taken followed by clinical examination of the oral mucosa and palpation of regional lymph nodes. Read More

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http://www.ascro.hr/fileadmin/user_upload/2017/Number_2017-4
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http://dx.doi.org/10.15644/asc51/4/7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975450PMC
December 2017
6 Reads

Cytological Findings of Malignant and Benign Head and Neck Masses in Somalia.

Authors:
Yılmaz Baş

Acta Cytol 2018 11;62(3):183-192. Epub 2018 Apr 11.

Hitit University, Erol Olçok Education and Research Hospital, Department of Pathology, Çorum, Turkey.

Objective: There are no up-to-date records on head and neck masses (HNMs) in Somalia. This cytological study is the first to demonstrate the benefits and findings of fine-needle aspiration cytology in evaluating HNMs in the adult population of Somalia.

Study Design: A total of 116 aspiration samples were taken from different levels of the neck region, except for the thyroid. Read More

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http://dx.doi.org/10.1159/000488021DOI Listing
June 2018
6 Reads

Acellular Human Dermal Allograft as a Graft for Nasal Septal Perforation Reconstruction.

Plast Reconstr Surg 2018 06;141(6):1517-1524

Edmonton, Alberta, and Toronto, Ontario, Canada From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta; and the Department of Otolaryngology-Head and Neck Surgery, Department of Surgical Oncology, University Health Network, University of Toronto.

Background: Nasal septal perforations pose a troubling source of morbidity for patients and a difficult problem for the otolaryngologist. Multiple surgical techniques have been tried, with inconsistent success. Prosthetic nasal buttons also have limitations, including patient intolerance and dissatisfaction. Read More

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http://Insights.ovid.com/crossref?an=00006534-201806000-0003
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http://dx.doi.org/10.1097/PRS.0000000000004410DOI Listing
June 2018
16 Reads

[Manifestation of eosinophilic granulomatosis with polyangiitis in the head and neck area over time taking systemic disease activity into consideration].

Z Rheumatol 2018 Dec;77(10):928-937

Klinik für HNO-Heilkunde, Kopf- und Halschirurgie, Christian-Albrechts-Universität zu Kiel, Arnold-Heller-Str. 3, Haus 27, 24105, Kiel, Deutschland.

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare granulomatous vasculitis of the small and medium sized blood vessels of unknown etiology. A regular involvement of the head and neck area is known. Since it is not yet known whether the inflammatory processes in the head and neck area are parallel to the systemic disease activity, the course of systemic and local disease activity was investigated in a comparative study. Read More

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http://dx.doi.org/10.1007/s00393-018-0439-0DOI Listing
December 2018
26 Reads

Subtotal Petrosectomy and Cochlear Implant Placement in Otologic Presentation of "Wegener's Granulomatosis".

Kathmandu Univ Med J (KUMJ) 2017 Jan.-Mar.;15(57):94-98

Department of Otorhinolaryngology, Head and Neck Surgery, Luzerner Kantonsspital, Luzern, Switzerland.

Granulomatosis with polyangitis is a rare granuloma forming necrotizing vasculitis, which involves mainly the respiratory tract and renal system. Otologic involvement may occur primarily as chronic serous otitis media and chronic silent mastoiditis with conductive hearing loss and may rarely lead to sensorineural hearing loss requiring cochlear implantation. This case describes a patient with granulomatous poylangitis with profound sensorineural hearing loss who underwent subtotal petrosectomy with cochlear implantation. Read More

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June 2018
3 Reads

Oral manifestation of sarcoidosis: A case report and review of the literature.

J Indian Soc Periodontol 2016 Nov-Dec;20(6):627-629

Department of Dentistry, Faculty of Medicine, University Hospital Hradec Králové, Charles University, Prague, Czech Republic.

Sarcoidosis is a common multisystemic granulomatous disease characterized by the formation of nonnecrotizing epithelioid granulomas in various body organs. The most commonly affected organs in the head-and-neck region include salivary glands and cervical lymph nodes. Involvement of the oral mucosa is very rare. Read More

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http://dx.doi.org/10.4103/jisp.jisp_378_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713087PMC
December 2017
5 Reads

Systemic granulomatous disease in dairy cattle during a dicyandiamide feeding trial.

N Z Vet J 2018 Mar 20;66(2):108-113. Epub 2017 Dec 20.

c Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11-222, Palmerston North , 4442 , New Zealand.

Case History: Mature, in-calf, non-lactating, Friesian or Friesian-cross cows were fed dicyandiamide (DCD) at daily doses of 0.15 g/kg (Group 1; n=31), 0.45 g/kg (Group 2; n=21) and 0. Read More

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http://dx.doi.org/10.1080/00480169.2017.1412840DOI Listing
March 2018
5 Reads

Solitary nodule of angiolymphoid hyperplasia with eosinophilia of the back masquerading as pyogenic granuloma.

Mol Clin Oncol 2017 Nov 19;7(5):874-876. Epub 2017 Sep 19.

Department of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare chronic inflammatory disorder of unknown etiology that most commonly presents as painless lymphadenopathy or subcutaneous masses in the head and neck region. The pathogenesis of the disease is not yet clear. The differential diagnosis is determined using characteristic histological features, such as significant vascular proliferation, lymphocytes and eosinophil inflammation in the dermis. Read More

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http://dx.doi.org/10.3892/mco.2017.1423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700265PMC
November 2017
4 Reads

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease.

Audiol Neurootol 2017 28;22(3):190-195. Epub 2017 Oct 28.

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Read More

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http://dx.doi.org/10.1159/000481426DOI Listing
July 2018
10 Reads

Mastoidectomy in a child with chronic granulomatous disease.

Br J Hosp Med (Lond) 2017 Oct;78(10):586-587

Assistant Professor, Department of Otorhinolaryngology-Head and Neck Surgery, Jeju National University School of Medicine, Jeju 63243, Republic of Korea.

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http://dx.doi.org/10.12968/hmed.2017.78.10.586DOI Listing
October 2017
9 Reads

Transesophageal Echocardiogram-Guided Stent Placement in Superior Vena Cava Syndrome Secondary to Granulomatous Lung Disease: A Case Series and Literature Review.

Vasc Endovascular Surg 2017 Nov 10;51(8):562-566. Epub 2017 Oct 10.

2 Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.

Obstruction of the superior vena cava (SVC) is an uncommon, but potentially life-threatening condition due to likely development of edema in the head and neck and potential respiratory compromise. Less than half of those affected by SVC syndrome survive more than a year. Obstruction can be from neoplasms or secondary to benign disease. Read More

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http://dx.doi.org/10.1177/1538574417723157DOI Listing
November 2017
16 Reads

CERVICAL LYMPHADENOPATHY IN IBADAN, NIGERIA.

Ann Ib Postgrad Med 2017 Jun;15(1):41-44

Department of Pathology, University College Hospital Ibadan, Nigeria.

Aim: To determine the pattern and causes of lymph node enlargement of cervical region in Ibadan, Nigeria.

Materials And Methods: A 10-year (2003-2012) retrospective study was conducted on all head and neck lymph node biopsies received at the Department of Pathology, University College Hospital, Ibadan, Nigeria.

Results: A total of 101 lymph node biopsies of cervical region were received within this period of study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598441PMC
June 2017
5 Reads

Prospective experience of percutaneous endoscopic gastrostomy tubes placed by otorhinolaryngologist-head and neck surgeons: safe and efficacious.

Eur Arch Otorhinolaryngol 2017 Nov 1;274(11):3971-3976. Epub 2017 Sep 1.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029, Helsinki, Finland.

Percutaneous endoscopic gastrostomy (PEG) is often the treatment of choice in head and neck cancer (HNC) patients needing long-term nutritional support. Prospective studies on PEG tube placement in an otorhinolaryngologist service are lacking. At our hospital, otolaryngologist-head and neck (ORL-HN) surgeons-have performed PEG insertions for HNC patients since 2008. Read More

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http://dx.doi.org/10.1007/s00405-017-4732-3DOI Listing
November 2017
39 Reads

Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis.

Clin Otolaryngol 2018 02 17;43(1):335-340. Epub 2017 Aug 17.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://doi.wiley.com/10.1111/coa.12943
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http://dx.doi.org/10.1111/coa.12943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775941PMC
February 2018
5 Reads

Sarcoidosis Presenting as Bilateral Vocal Fold Immobility.

J Voice 2018 May 3;32(3):359-362. Epub 2017 Jul 3.

Head and Neck Regeneration Program, Center for Regenerative Medicine, Mayo Clinic, Phoenix, Arizona; Department of Otorhinolaryngology, Mayo Clinic Arizona, Phoenix, Arizona. Electronic address:

Bilateral true vocal fold paralysis is rarely attributable to inflammatory diseases. Sarcoidosis is a rare but important etiology of bilateral true vocal fold paralysis by compressive lymphadenopathy, granulomatous infiltration, and neural involvement. We describe the first reported case of sarcoidosis presenting as bilateral vocal fold immobility caused by direct fixation by granulomatous infiltration severe enough to necessitate tracheostomy insertion. Read More

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http://dx.doi.org/10.1016/j.jvoice.2017.05.017DOI Listing
May 2018
8 Reads

Fungal granulomatous disease of the nasal cavity: A case report of a rare entity.

Am J Otolaryngol 2017 Sep - Oct;38(5):642-644. Epub 2017 May 8.

Department of Otolaryngology/Head and Neck Surgery, Westchester Medical Center, ENT Faculty Practice, 100 Woods Rd., Valhalla, NY 10595, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S01960709173033
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http://dx.doi.org/10.1016/j.amjoto.2017.05.005DOI Listing
July 2018
14 Reads

Kimura's disease affecting the axillary lymph nodes: a case report.

BMC Surg 2017 May 26;17(1):63. Epub 2017 May 26.

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.

Background: Kimura's disease (KD; eosinophilic granuloma of soft tissue) is an inflammatory granulomatous disorder of unknown cause with eosinophilic infiltration that occurs mainly in soft tissue. KD occurs mainly in the head and neck, but development in the axillary region is very rare.

Case Presentation: A 74-year-old Japanese woman was evaluated for a mass that she noted in the left axillary region. Read More

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http://dx.doi.org/10.1186/s12893-017-0260-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446720PMC
May 2017
19 Reads

Systemic granulomatous and haemorrhagic syndrome in New Zealand dairy cattle.

N Z Vet J 2017 May 15;65(3):156-162. Epub 2017 Feb 15.

f Gribbles Veterinary Pathology , Christchurch , New Zealand.

Case History: Cases were obtained through passive surveillance reporting by veterinary pathologists, via the Ministry for Primary Industries Exotic Pest and Disease Hotline. They included ill or dead cows that had evidence of frank haemorrhage, petechial haemorrhages on mucous membranes, wasting or dermatitis of unknown cause, and were reported between 2009-2014. Affected cows (n=16) were from nine seasonally calving dairy farms, aged ≥3 years, and were predominantly in their mid-to-late non-lactating period. Read More

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http://dx.doi.org/10.1080/00480169.2017.1281773DOI Listing
May 2017
7 Reads

European Association for Cardio-Thoracic Surgery expert consensus statement on the prevention and management of mediastinitis.

Eur J Cardiothorac Surg 2017 Jan;51(1):10-29

Unit of Thoracic Surgery, Azienda Ospedaliera S. Camillo Forlanini, Lazzaro Spallanzani Hospital, Rome, Italy.

Mediastinitis continues to be an important and life-threatening complication after median sternotomy despite advances in prevention and treatment strategies, with an incidence of 0.25-5%. It can also occur as extension of infection from adjacent structures such as the oesophagus, airways and lungs, or as descending necrotizing infection from the head and neck. Read More

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http://dx.doi.org/10.1093/ejcts/ezw326DOI Listing
January 2017
14 Reads
1 Citation
3.304 Impact Factor

Chronic invasive fungal sinusitis: characterization and shift in management of a rare disease.

Int Forum Allergy Rhinol 2016 12 27;6(12):1294-1300. Epub 2016 Jul 27.

Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH.

Background: Chronic invasive fungal sinusitis (CIFS) is a rare subtype of mycotic diseases involving the paranasal sinuses. It is characterized by a slow onset and invasive organisms with non-granulomatous inflammation seen on histopathology. Historically, treatment has involved radical surgical resection. Read More

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http://dx.doi.org/10.1002/alr.21828DOI Listing
December 2016

The results of Kaplan-Meier and multivariate analyses of etiological factors related to the outcome of combined pharmacological therapy against laryngeal granuloma.

Acta Otolaryngol 2016 Nov 22;136(11):1141-1146. Epub 2016 Jun 22.

a Department of Otorhinolaryngology, Head and Neck Surgery , Osaka University Graduate School of Medicine , Suita , Japan.

Conclusions: The present results indicate that the diagnosis of gastroesophageal reflux disease (GERD) is an independent etiological factor predicting retardation of the resolution of laryngeal granuloma.

Objectives: To assess the effects of combined usage of an inhaled corticosteroid plus tranilast and/or a proton pump inhibitor on the size of granulomatous lesions, and to reveal etiological factors related to the outcome using the Kaplan-Meier method and a subsequent multivariate analysis.

Methods: Sixty-two patients with laryngeal granuloma were enrolled. Read More

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http://dx.doi.org/10.1080/00016489.2016.1193891DOI Listing
November 2016
16 Reads

Unilateral Eyelid Edema as Initial Sign of Orbital Sarcoidosis.

Case Rep Ophthalmol Med 2016 19;2016:6912927. Epub 2016 May 19.

Department of Ophthalmology, Hospital Ana Costa, 11050-120 Santos, SP, Brazil.

Introduction. Sarcoidosis is a rare multisystemic granulomatous inflammatory disease of unknown etiology affecting the respiratory system, skin, and eyes. Sarcoidosis outside the lacrimal gland is rare. Read More

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http://dx.doi.org/10.1155/2016/6912927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889789PMC
June 2016
2 Reads

Nivolumab-Induced Sarcoid-Like Granulomatous Reaction in a Patient With Advanced Melanoma.

Chest 2016 May;149(5):e133-6

Dermatology Department, Assistance Publique - Hôpitaux de Paris, Saint Louis Hospital, Paris, France; Clinical Investigation Department, Assistance Publique - Hôpitaux de Paris, Saint Louis Hospital, Paris, France; Onco-Dermatology, Immunology and Cutaneous Stem Cells, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

To our knowledge, we report the first case of sarcoid-like granulomatous reaction induced by nivolumab, a fully human IgG4 anti-programmed death 1 (PD-1) immune checkpoint inhibitor antibody. A 57-year-old man was treated with nivolumab 3 mg/kg for 2 weeks for a desmoplastic melanoma stage III American Joint Commission on Cancer, with no BRAF, NRAS, and cKit mutations. At 10 months, although melanoma complete response was achieved, he developed sarcoid-like granulomatous reaction in the mediastinal lymph node and skin, which resumed after nivolumab arrest. Read More

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http://dx.doi.org/10.1016/j.chest.2015.10.082DOI Listing
May 2016
23 Reads

A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base.

Am J Trop Med Hyg 2016 Jul 2;95(1):88-91. Epub 2016 May 2.

Academic Hospital Paramaribo, Paramaribo, Suriname.

We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. Read More

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http://dx.doi.org/10.4269/ajtmh.15-0792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944716PMC
July 2016
4 Reads

Spontaneous Oral Mucosal Bleeding Unmasking Undiagnosed Sarcoidosis: A Case Report.

Dent Update 2016 May;43(4):353-5

Sarcoidosis is a multisystem, non-caseating, chronic, granulomatous disease affecting any organ. In the head and neck region, salivary glands and lymph nodes are most commonly involved. Oral manifestations are rare but these lesions, occasionally haemorrhagic, may be the first sign of systemic disease. Read More

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http://dx.doi.org/10.12968/denu.2016.43.4.353DOI Listing
May 2016
14 Reads

Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis.

PLoS One 2016 14;11(4):e0153450. Epub 2016 Apr 14.

Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, Brazil.

Introduction: Laryngeal tuberculosis (LTB) is the most frequent granulomatous disease of the larynx and represents less than 2% of extrapulmonary TB cases. There are no pathognomonic clinical and endoscopic features of this disease and studies on LTB that can assist in its diagnostic characterization are lacking.

Objective: To identify factors associated with clinical and topographical features of LTB. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153450PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831755PMC
August 2016
13 Reads

Granulomatosis With Polyangiitis in Otolaryngologist Practice: A Review of Current Knowledge.

Clin Exp Otorhinolaryngol 2016 Mar 7;9(1):8-13. Epub 2016 Mar 7.

Department and Clinic of Otolaryngology-Head and Neck Surgery, Wrocław, Poland.

Granulomatosis with polyangiitis (GPA) is an idiopathic vasculitis of medium and small arteries, characterized by necrotizing granulomatous inflammation. GPA typically affects upper and lower respiratory tract with coexisting glomerulonephritis. This disease is generally characterized by antineutrophil cytoplasm antibodies (ANCA), nevertheless, there are rare cases with negative ANCA. Read More

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http://dx.doi.org/10.21053/ceo.2016.9.1.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792240PMC
March 2016
4 Reads

Granulomatous ulcers of the nose and oropharynx: Lupus vulgaris revisited.

Ear Nose Throat J 2016 Feb;95(2):E49-51

From the Department of Otorhinolaryngology-Head and Neck Surgery, Medical College and Hospital, Kolkata, West Bengal, India (Dr. Dutta and Dr. Sinha); and the Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine and Sagore Dutta Hospital, Kolkata (Dr. Ghatak).

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http://dx.doi.org/10.1177/014556131609500213DOI Listing
February 2016
3 Reads

Nasopharyngeal granulomatous mass after radiotherapy for nasopharyngeal carcinoma.

Auris Nasus Larynx 2016 Jun 11;43(3):330-5. Epub 2016 Jan 11.

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: To evaluate the diagnosis, management and nasal endoscopic surgical outcome of nasopharyngeal granulomatous mass in post-radiation nasopharyngeal carcinoma (NPC) patients.

Materials And Methods: A total of 23 cases of granulomatous mass after radiotherapy for NPC from 2008 to 2013 treated with nasal endoscopic surgery were retrospectively reviewed.

Results: Radiotherapy dose (p=0. Read More

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http://dx.doi.org/10.1016/j.anl.2015.10.005DOI Listing
June 2016
23 Reads

[Clinical and histological characteristics of adenopathies in paediatric patients].

Rev Chil Pediatr 2016 Jul-Aug;87(4):255-60. Epub 2016 Jan 6.

Departamento de Pediatría, Universidad Pontificia Bolivariana, Medellín, Colombia; Departamento de Pediatría, Universidad del Valle, Cali, Colombia. Electronic address:

Background: Lymphadenopathy is a common cause for medical consultation in the child population, accounting for up to 44% in children under 5 years old. In some cases, it is required to take lymph node biopsy specimens in order to clarify the diagnosis.

Objective: To describe the clinical and histological features of paediatric patients with lymphadenopathy and lymph node biopsies. Read More

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http://dx.doi.org/10.1016/j.rchipe.2015.11.007DOI Listing
April 2017
32 Reads

Clinic manifestations in granulomatosis with polyangiitis.

Int J Immunopathol Pharmacol 2016 Jun 18;29(2):151-9. Epub 2015 Dec 18.

Policlinico "Umberto I" - Rome, Department of Organs of Sense - ENT Section, University of Rome "La Sapienza", Italy.

Granulomatosis with polyangiitis (GPA), formerly Wegener's granulomatosis (WG), is an uncommon immunologically mediated systemic small-vessel vasculitis that is pathologically characterised by an inflammatory reaction pattern (necrosis, granulomatous inflammation and vasculitis) that occurs in the upper and lower respiratory tracts and kidneys. Although the aetiology of GPA remains largely unknown, it is believed to be autoimmune in origin and triggered by environmental events on a background of genetic susceptibility.In Europe, the prevalence of GPA is five cases per 100,000 population, with greater incidence in Northern Europe. Read More

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http://dx.doi.org/10.1177/0394632015617063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806708PMC
June 2016
11 Reads

Sinonasal sarcoidosis of the maxillary sinus and infraorbital nerve: a case report.

J Korean Assoc Oral Maxillofac Surg 2015 Aug 21;41(4):217-21. Epub 2015 Aug 21.

Department of Oral Medicine and Radiology, Kunhitharuvai Memorial Charitable Trust (KMCT) Dental College and Hospitals, Kozhikode, India.

Sinonasal sarcoidosis in the head and neck region is infrequent. Its occurrence can be either isolated in combination with other systems. The literature reveals that the occurrence of sinonasal sarcoidosis without lung involvement is rare. Read More

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http://dx.doi.org/10.5125/jkaoms.2015.41.4.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558193PMC
August 2015
2 Reads

Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma.

Am J Rhinol Allergy 2015 Jul-Aug;29(4):e95-9

Otolaryngology, Head and Neck Department, Minia University, Minia, Egypt.

Background: Rhinoscleroma is a chronic granuloma that is endemic in Egypt and is caused by gram-negative bacilli (Klebsiella rhinoscleromatis). The nasal mucosa is affected in almost all cases, which causes nasal obstruction, anosmia, and epistaxis. The disease usually passes through an atrophic stage (atrophic rhinitis) and a granulomatous stage before ending in the fibrotic stage, with possible bone destruction. Read More

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http://dx.doi.org/10.2500/ajra.2015.29.4197DOI Listing
May 2016
20 Reads

Chronic invasive fungal sinusitis associated with intranasal drug use.

Laryngoscope 2015 Dec 7;125(12):2656-9. Epub 2015 Jul 7.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.

Chronic invasive fungal sinusitis (CIFS) is a rare but potentially aggressive form of invasive fungal disease that occurs in immunocompetent patients. We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Read More

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http://www.researchposters.com/Posters/COSM/COSM2015/G017.pd
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http://doi.wiley.com/10.1002/lary.25429
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http://dx.doi.org/10.1002/lary.25429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725714PMC
December 2015
6 Reads

Laryngeal sarcoidosis: presentation and management in the pediatric population.

Int J Pediatr Otorhinolaryngol 2015 Sep 25;79(9):1382-7. Epub 2015 Jun 25.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, 333 Longwood Ave, 3rd Floor, Boston, MA 02115, USA; Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA. Electronic address:

Background: Sarcoidosis is a disease characterized by systemic non-necrotizing granulomas of unknown etiology. Laryngeal sarcoidosis is extremely uncommon, especially among pediatric patients. The clinical presentation and management of this entity in the pediatric population are poorly understood. Read More

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http://dx.doi.org/10.1016/j.ijporl.2015.06.017DOI Listing
September 2015
1 Read

Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma.

Am J Rhinol Allergy 2015 Jul;29(4):95-99

Otolaryngology, Head and Neck Department, Minia University, Minia, Egypt.

Background: Rhinoscleroma is a chronic granuloma that is endemic in Egypt and is caused by gram-negative bacilli (Klebsiella rhinoscleromatis). The nasal mucosa is affected in almost all cases, which causes nasal obstruction, anosmia, and epistaxis. The disease usually passes through an atrophic stage (atrophic rhinitis) and a granulomatous stage before ending in the fibrotic stage, with possible bone destruction. Read More

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http://dx.doi.org/10.2500/ajra.2015.29.4197DOI Listing
July 2015
2 Reads

Searching for a rat model of chronic tympanic membrane perforation: Healing delayed by mitomycin C/dexamethasone but not paper implantation or iterative myringotomy.

Int J Pediatr Otorhinolaryngol 2015 Aug 27;79(8):1240-7. Epub 2015 May 27.

Ear Sciences Centre, School of Surgery, The University of Western Australia, Perth, WA, Australia; Ear Science Institute Australia, Perth, WA, Australia.

Objectives: Surgical intervention such as myringoplasty or tympanoplasty is an option in the current clinical management of chronic tympanic membrane perforation (TMP). Animal models of chronic TMP are needed for pre-clinical testing of new materials and to improve existing techniques. We evaluated several reported animal model techniques from the literature for the creation of chronic TMPs. Read More

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http://dx.doi.org/10.1016/j.ijporl.2015.05.020DOI Listing
August 2015
6 Reads

Laryngeal tuberculosis: A report of 17 cases.

Auris Nasus Larynx 2015 Aug 3;42(4):305-10. Epub 2015 Mar 3.

Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, Japan.

Objective: The aim of this study was to reduce misdiagnosis and inappropriate treatment of laryngeal tuberculosis.

Methods: Between April 2009 and March 2013, 1660 inpatients with tuberculosis were treated at the Osaka Prefectural Medical Center for Respiratory and Allergic Diseases. Seventeen of these patients were diagnosed with laryngeal tuberculosis. Read More

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http://dx.doi.org/10.1016/j.anl.2015.02.012DOI Listing
August 2015
7 Reads

Head and neck tuberculosis: 6-year retrospective study.

Acta Otorrinolaringol Esp 2016 Jan-Feb;67(1):9-14. Epub 2015 Jan 25.

Servicio de ORL, Complejo Hospitalario Universitario de Vigo, Vigo, España.

Introduction: Pulmonary involvement exists in 80% of cases of infection with Mycobacterium tuberculosis; however, in up to 20% of cases there may be extra-pulmonary involvement. In the ENT area, the most common site is cervical lymphadenitis, affecting approximately 95% of cases.

Materials And Methods: This was a retrospective study of patients attending an ENT department in a tertiary hospital for head and neck symptoms that were diagnosed with tuberculosis (TB), between December 2007 and December 2013. Read More

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http://dx.doi.org/10.1016/j.otorri.2014.11.003DOI Listing
September 2017
7 Reads
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