246 results match your criteria Granulomatous Diseases of the Head and Neck


Laryngeal Sarcoidosis and Swallowing: What Do We Know About Dysphagia Assessment and Management in this Population?

Dysphagia 2021 May 26. Epub 2021 May 26.

Department of Otolaryngology, Head and Neck Surgery, National Centre for Airway Reconstruction, Imperial College Healthcare NHS Trust, London, UK.

Introduction: Sarcoidosis is a chronic granulomatous disease of unknown aetiology and laryngeal involvement is seen in a small percentage of cases. Dysphagia is a common but under-reported symptom. Little is known about how dysphagia typically presents or is managed in the context of this fluctuating disease. Read More

View Article and Full-Text PDF

Nasal-type extranodal NK/T-cell lymphoma presenting as recurrent periorbital cellulitis.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Otolaryngology, Tallaght University Hospital, Dublin, Dublin, Ireland.

Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) is a rare disease with a poor prognosis. It has features similar to other granulomatous and infectious diseases of the nose and paranasal sinuses, which can make diagnosis challenging and delayed. We present a case of 38-year-old man who was admitted to the hospital on three occasions over a 3-month period for right periorbital erythema, nasal congestion and discharge. Read More

View Article and Full-Text PDF

Invasive, aggressive mastoid bone eumycetoma: a treatment challenge.

Trans R Soc Trop Med Hyg 2021 Apr;115(4):431-435

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a chronic granulomatous disease that significant affects the subcutaneous tissue and deep structures. Mycetoma is caused by certain fungi (eumycetoma) or higher bacteria (actinomycetoma). The clinical presentation is variable and depends on the causative agent. Read More

View Article and Full-Text PDF

Managing a Complicated Acute Otomastoiditis at Day Four of Life.

Cureus 2021 Jan 25;13(1):e12905. Epub 2021 Jan 25.

Otolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Acute mastoiditis in a newborn complicated by the presence of facial nerve palsy is an alarming finding requiring rapid assessment and further investigation. Such an early presentation should point the clinician towards an underlying systemic pathology or congenital anatomical abnormality. Facial nerve involvement indicates severe infection and possible dehiscence of the facial canal. Read More

View Article and Full-Text PDF
January 2021

Tolosa-Hunt Syndrome Misdiagnosed as Surgical Complication After Frontal Balloon Sinuplasty.

J Craniofac Surg 2021 Jan 28. Epub 2021 Jan 28.

Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine Department of Neurology, Konyang University College of Medicine, Daejeon, Republic of Korea.

Abstract: Tolosa-Hunt syndrome (THS) is a rare benign disease caused by granulomatous inflammation in the craniofacial region. It is mostly idiopathic and generally presents with painful ophthalmoplegia, ipsilateral oculomotor paresis, and steroid responsiveness. There are few reports of THS after sinus surgery. Read More

View Article and Full-Text PDF
January 2021

Extensive bony sarcoidosis of the head and neck region: a rare presentation.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Oral and Maxillofacial Surgery, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, Derbyshire, UK.

We present a rare case of sarcoidosis with extensive bony destruction of the maxillofacial and skull base bones. A 65-year-old woman was referred with an asymptomatic, non-healing dental socket. Examination revealed an oroantral fistula that was biopsied and repaired under general anaesthesia. Read More

View Article and Full-Text PDF
January 2021

An uncommon case of lip swelling: Granulomatous cheilitis associated with Crohn's disease.

Am J Otolaryngol 2021 Mar-Apr;42(2):102897. Epub 2021 Jan 4.

Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh School of Medicine, United States of America. Electronic address:

Unbeknownst to most otolaryngologists, there is quite a range of oral manifestations which commonly manifest in the context of inflammatory bowel disease. As providers who will encounter such patients in consultation it is beneficial to be aware of that association. Lip swelling (granulomatous cheilitis) is just one such presentation, which is often otherwise mistaken for angioneurotic edema and can lead to unwarranted testing and misdirected treatment. Read More

View Article and Full-Text PDF
January 2021

Diagnostic performance of EBUS-TBNA and its interrelation with PET-CT in patients with extra-thoracic malignancies.

Tuberk Toraks 2020 Sep;68(3):285-292

Department of Chest Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic tool for lung cancer, sarcoidosis, and suspected metastatic extra-thoracic malignancy (ETM). Patients with primary ETM often have hypermetabolic mediastinal/hilar lymph node enlargement in the PET-scan done for initial staging or post treatment followup. We aimed to determine the diagnostic performance of EBUS-TBNA and the relationship between PET-SUV values and diagnosis of malignancy metastasis in patients with ETM. Read More

View Article and Full-Text PDF
September 2020

Parotitis caused by Mycobacteroides abscessus subspecies abscessus.

Auris Nasus Larynx 2020 Nov 24. Epub 2020 Nov 24.

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Rapidly growing mycobacteria rarely causes parotitis. We report a rare case of Mycobacteroides abscessus subspecies abscessus (MAB) parotitis in a previously healthy 26-year-old woman. She presented to the previous hospital with a swelling over the right parotid region, and a computed tomography scan revealed multiple abscesses in the swollen parotid gland. Read More

View Article and Full-Text PDF
November 2020

Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient.

Ear Nose Throat J 2020 Nov 25:145561320973772. Epub 2020 Nov 25.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, 5232University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

A 12-year-old male with a family history of inflammatory bowel disease presented with sleep-disordered breathing and was found to have chronic, granulomatous swelling of the supraglottic larynx. His airway was managed with tracheostomy, regular interval laryngeal steroid injections, supraglottoplasty, and "pepper pot" CO2 laser resurfacing leading to eventual decannulation. Due to the non-necrotic nature of the granulomatous inflammation, as well as the patient's family history of inflammatory bowel disease, the leading diagnosis was Crohn disease, but isolated laryngeal sarcoidosis could not be ruled out. Read More

View Article and Full-Text PDF
November 2020

A rare case of pediatric Crohn's disease and alveolar bone loss: a report and review.

Transl Pediatr 2020 Oct;9(5):720-725

Department of Stomatology, the Children's Hospital, Zhejiang University School of Medicine, National Clinic Research Center for Child Health, Hangzhou, China.

Crohn's disease (CD) is a granulomatous inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, but its etiology is still unclear. CD patients usually have extraintestinal manifestations including oral manifestations, and this can also occasionally appear in children. Oral manifestations, including aphthous stomatitis, typically develop on the mucocutaneous tissue. Read More

View Article and Full-Text PDF
October 2020

A rare case presentation of Tuberculous Otitis Media with turner syndrome.

Indian J Tuberc 2020 Jul 2;67(3):444-447. Epub 2020 Jul 2.

Department of Otolaryngology, Head and Neck Surgery, AIIMS, Raipur, India.

A 17-year-old female patient who came to the Otorhinolaryngology and Head and Neck Surgery department with chief complaints of bilateral ear discharge and hearing loss Since 1 year. She was diagnosed as a case of Turner syndrome based on Cardic-CT, USG-pelvis, CT-MRI Pelvis with Abdomen Screening, and Chromosomal analysis revealed 45, X pattern in all the metaphases. In the Preoperative investigations, Pure tone audiometry shows left ear (83dB HL) severe mixed hearing loss and right ear has (63dB HL) with moderately severe mixed hearing loss and in HRCT-Temporal bone features suggesting the most possibility of bilateral Cholesteatoma. Read More

View Article and Full-Text PDF

Granulomatous inflammation in lymph nodes of the head and neck-a retrospective analysis of causes in a population with very low incidence of tuberculosis.

Immunol Res 2020 08;68(4):198-203

Department of ORL-Head & Neck Surgery, Odense University Hospital, Odense, Denmark.

The purpose of this study was to investigate the risk of the patient having: (1) TB, (2) sarcoidosis, (3) atypical mycobacteria, or (4) malignant disease, if FNAC or histology from a cervical lymph node shows granulomatous inflammation (GI). And to elucidate clinical characteristics associated with these causes of GI, patients with a pathological diagnosis of GI in head and neck lymph nodes were identified though a search of the Danish national pathology database. Charts were reviewed to identify the final clinical diagnosis and specific clinical characteristics. Read More

View Article and Full-Text PDF

Neurosarcoidosis Directly Involving the Cervical Vagus Nerve.

Ann Otol Rhinol Laryngol 2021 Feb 13;130(2):215-218. Epub 2020 Jul 13.

Department of Otolaryngology - Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

Objectives: To present a novel location in which neurosarcoidomatous inflammation is identified and its accompanying presentation.

Methods: The authors present a case of bilateral vocal fold paresis associated with non-caseating granulomatous inflammation of the cervical and intra-axial portions of the vagus nerve masquerading as a cranial nerve tumor.

Results: Examination revealed bilateral vocal fold paresis and asymmetric palate elevation. Read More

View Article and Full-Text PDF
February 2021

Cat-scratch Disease with Parinaud's Oculoglandular Syndrome.

Turk Arch Otorhinolaryngol 2020 Mar 26;58(1):48-51. Epub 2020 Mar 26.

Department of Otorhinolaryngology - Head and Neck Surgery, Hospital de Braga, Braga, Portugal.

Cat-scratch disease (CSD) is one of the most common causes of infectious cervicofacial lymphadenopathies in children, adolescents, and young adults. With this case report, we highlight the wide spectrum of atypical manifestations of CSD in an elderly patient who presented not only with cervicofacial lymphadenopathies but also parotid enlargement, and Parinaud's oculoglandular syndrome which comprises granulomatous nonsuppurative conjunctivitis with adjacent ipsilateral preauricular lymphadenopathy. A high index of suspicion is needed to correctly diagnose and treat this clinical entity. Read More

View Article and Full-Text PDF

Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form.

Case Rep Endocrinol 2020 17;2020:6284764. Epub 2020 Mar 17.

Department of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.

Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. Read More

View Article and Full-Text PDF

Nasofacial rhinoentomophthoramycosis: A report of two cases from Central India.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S124-S127. Epub 2020 Feb 28.

Department of ENT, Head and Neck Surgery, AIIMS Raipur, Raipur, Chhattisgarh, India.

Rhinoentomophthoromycosis due to is a rare, chronic, granulomatous disease, occurring mainly in tropical countries including India. We report two cases of rhinoentomophthoromycosis in an 18-year-old female and a farmer of 35 years residents of Chhattisgarh shifted from Madhya Pradesh and Orrisa. It was diagnosed by microscopy and isolation in culture. Read More

View Article and Full-Text PDF
February 2020

Long-term outcome of surgical excision for treatment of cervicofacial granulomatous lymphadenitis in children.

Eur Arch Otorhinolaryngol 2020 Jun 6;277(6):1785-1792. Epub 2020 Mar 6.

Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain, Brussels, Belgium.

Purpose: Granulomatous inflammation is a common cause of subacute cervicofacial lymphadenitis in children. Nontuberculous mycobacterial (NTM) infections and cat-scratch disease (CSD) are the most frequent causes. Optimal treatment, which may include surgery, antibiotic treatment or wait-and-see approach, is debatable. Read More

View Article and Full-Text PDF

Supraglottic laryngeal sarcoidosis masquerading as supraglottitis.

BMJ Case Rep 2020 Jan 13;13(1). Epub 2020 Jan 13.

Otolaryngology Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Perth, Western Australia, Australia.

Sarcoidosis is a rare multisystem disorder of unknown aetiology characterised by non-caseating granulomas in involved organs; it is a diagnosis of exclusion. Laryngeal involvement affects only 0.5%-5% of those with sarcoidosis. Read More

View Article and Full-Text PDF
January 2020

Clinical features of sarcoidosis patients presenting with head and neck manifestations - a two-center retrospective study and proposal of a diagnostic algorithm for the otorhinolaryngologist.

Acta Otolaryngol 2020 Feb 11;140(2):144-148. Epub 2019 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich, Munich, Germany.

We aimed to investigate the clinical characteristics of patients presenting with sarcoidosis of the head and neck as the initial manifestation and to provide recommendations for the diagnostic work-up for the practicing otorhinolaryngologist. We performed a retrospective cohort study at two university medical centers in Germany. Patients with a histopathologically confirmed diagnosis of sarcoidosis treated in the otorhinolaryngology departments were analyzed. Read More

View Article and Full-Text PDF
February 2020

Kimura's Disease: A Rare Cause of Parotid Swelling.

Indian J Otolaryngol Head Neck Surg 2019 Oct 18;71(Suppl 1):589-593. Epub 2018 Jun 18.

1Department of ENT and Head and Neck Surgery, Dr. B.R. Ambedkar Medical College, Bangalore, India.

Kimura's disease also known as subcutaneous angioblastic lymphoid hyperplasia with peripheral eosinophilia is a rare clinicopathological entity. It is a chronic granulomatous disease of unknown etiology. The clinical presentation varies from subcutaneous swellings of the head and neck region with regional lymphadenopathy with salivary gland involvement to systemic manifestations like nephrotic syndrome. Read More

View Article and Full-Text PDF
October 2019

Neck as mediastinal extension: Diagnosis of sarcoidosis by core biopsy of cervical lymph nodes.

Clin Respir J 2020 Jan 23;14(1):16-20. Epub 2019 Oct 23.

Department of Radiology, New Cross Hospital, Wolverhampton, UK.

Background: Sarcoidosis is a multi-system granulomatous disease. The diagnostic procedures for histological confirmation are invasive and a less invasive approach to diagnostic pathway is warranted. The utility of diagnostic value of neck ultrasound was retrospectively evaluated. Read More

View Article and Full-Text PDF
January 2020

Cutaneous Bone Formation Associated With Melanocytic Nevus.

J Craniofac Surg 2019 Oct;30(7):e688-e691

Baskent University, Medicine Faculty, General Surgery Department, Konya Uygulama ve Arastirma Hastanesi, Selcuklu, Konya, Turkey.

Aim: Cutaneous bone formation is an uncommon lesion of the skin. It may be primary or secondary. Secondary lesions are mostly associated with melanocytic nevi. Read More

View Article and Full-Text PDF
October 2019

Head and Neck Manifestations of Granulomatosis with Polyangiitis: A Retrospective analysis of 19 Patients and Review of the Literature.

Int Arch Otorhinolaryngol 2019 Apr 1;23(2):165-171. Epub 2019 Mar 1.

Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain.

Granulomatosis with Polyangiitis (GPA) is a small vessel vasculitis characterized by a necrositing granulomatous inflammation of the upper and lower respiratory tracts and focal/proliferative glomerulonephritis. In more than 70% of the cases, the presenting symptoms are head and neck manifestations that are often misdiagnosed as infectious or allergic in etiology.  The present study provides an analysis of head and neck manifestations in a series of patients diagnosed with GPA. Read More

View Article and Full-Text PDF

Chronic non-granulomatous supraglottitis of a male adolescent and its successful management with azathioprine.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Ear, Nose and Throat Surgery, Monash Health, Clayton, Victoria, Australia.

Chronic non-granulomatous supraglottitis (CNGS) is a rare disorder of the supraglottic larynx, characterised by chronic supraglottic inflammation in the absence of granulomata, vasculitis, neoplasia, autoimmune disease or infective changes on histology. We present the case of a male adolescentwho attended with progressively worsening exertional dyspnoea, stridor and symptoms of obstructive sleep apnoea. Flexible nasendoscopy revealed marked supraglottic subepithelial thickening sparing the glottis and subglottis, confirmed on microlaryngoscopy. Read More

View Article and Full-Text PDF

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler.

Laryngoscope 2019 Nov 26;129(11):2534-2536. Epub 2019 Mar 26.

Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58-year-old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Read More

View Article and Full-Text PDF
November 2019

Sarcoidosis of the paranasal sinuses.

Eur Arch Otorhinolaryngol 2019 Jul 21;276(7):1969-1974. Epub 2019 Mar 21.

Department of Otorhinolaryngology, Munich University (LMU), Munich, Germany.

Background: Sarcoidosis is a chronic disease, which predominantly affects the lung. Since sinonasal sarcoidosis is rare, little is known about the sarcoidosis manifestation at this site. Therefore, the aim of our study was to detect the prevalence of sinonasal sarcoidosis, its clinical occurrence, diagnosis, and therapy. Read More

View Article and Full-Text PDF

Conversion to Chronic Invasive Fungal Sinusitis From Allergic Fungal Sinusitis in Immunocompetence.

Laryngoscope 2019 11 9;129(11):2447-2450. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, Georgia.

A review of the treatment of allergic and invasive fungal sinusitis, as well as a presentation of the first recorded case of a conversion from allergic fungal sinusitis (AFS) to chronic granulomatous invasive sinusitis and the fourth case of invasive fungal sinusitis associated with Curvularia. This immunocompetent patient suffering from chronic AFS converted after repeated high-dose steroid tapers and noncompliance. AFS may present atypically and should be suspected even in immunocompetent patients with sinus disease who report new onset pain and neurologic symptoms. Read More

View Article and Full-Text PDF
November 2019

An Unusual Case of Tertiary Syphilis Behaving Like Tongue Squamous Cell Carcinoma.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820355. Epub 2018 Dec 20.

Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, Sacramento, CA, USA.

Syphilis may present with a myriad of oral manifestations in the primary, secondary, and tertiary stages, and may be confused with malignancy. Despite a rise in the incidence of syphilis, tertiary syphilis is exceedingly rare. Tertiary syphilis gummas usually affect the hard palate, while tongue involvement is very rare. Read More

View Article and Full-Text PDF
September 2019

Magnetic resonance perfusion and diffusion characteristics of granulomatous diseases mimic those of malignant lesions: six case reports.

Oral Radiol 2018 01 16;34(1):73-82. Epub 2017 Mar 16.

Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki, 852-8588, Japan.

The perfusion and diffusion properties of a tumor are important clues in evaluating its growth potential and predicting its histological type, such as benign or malignant. Tumor perfusion can be estimated by assessing time-dependent changes in the intratumoral levels of the contrast agent during dynamic contrast-enhanced magnetic resonance (MR) imaging, whereas tumor diffusion can be estimated by assessing intratumoral water diffusivity on diffusion-weighted MR imaging. Granulomatous diseases with different etiologies occur in various head and neck regions, including the mandible, maxillary sinus, salivary glands, and lymph nodes. Read More

View Article and Full-Text PDF
January 2018