265 results match your criteria Granulomatous Diseases of the Head and Neck


Primary Cutaneous Anaplastic Large Cell Lymphoma of the Nasal Dorsum and Nasal Tip.

Cureus 2022 Apr 4;14(4):e23811. Epub 2022 Apr 4.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ioannina, Ioannina, GRC.

Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is described as a non-Hodgkin lymphoma that affects only the skin, with no evidence of an extracutaneous disease during the first six months following the diagnosis. We present an unusual case of a 53-year-old man with developed fever and a rapidly increasing ulcerated skin lesion located on the nasal dorsum and nasal tip. The nasal endoscopy revealed a reddish polypoid lesion over the anterior edge of the superior turbinate which had extended through the roof of the nasal cavity in the adjacent area of the nasal septum. Read More

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[IgG4-related disease with nasopharyngeal malignancy-like manifestations].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Apr;36(4):293-296

Department of Otolaryngology Head and Neck Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,510000,China.

The purpose of this article was to discuss the clinical features and imaging characteristics of IgG4-related disease(IgG4-RD) in order to identify nasopharyngeal IgG4-RD at an early stage. The basic information of the patients, including age, sex, symptoms, disease duration and treatment process, was collected through the electronic case system. Laboratory tests including nasal endoscopy, EBV levels, IgG4 levels and C-reactive protein levels were recorded during hospitalization and outpatient follow-up. Read More

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[Granulomatosis with polyangiitis with head and neck symptoms as the first clinical manifestation: clinical analysis of 28 cases].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;36(5):362-368

Department of Otolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University,Key Research Laboratory of Airway Neuroimmunology,Taiyuan,030001,China.

To investigate the early clinical features and diagnosis of granulomatous polyangiitis(GPA) with head and neck symptoms as the first presentation. The data of 28 patients with GPA diagnosed in the Second Hospital of Shanxi Medical University from 2014 to 2021, whose first symptoms appeared on the head and neck, were collected. All patients underwent relevant imaging examinations, laboratory tests, endoscopy, and pathological tissue biopsies. Read More

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Fatal epistaxis in a case of common variable immunodeficiency: A case report and review of the literature.

Clin Case Rep 2022 Mar 23;10(3):e05602. Epub 2022 Mar 23.

Department of Otorhinolaryngology, Head and Neck Surgery Auckland City Hospital Auckland New Zealand.

Common variable immunodeficiency (CVID) is a primary immunodeficiency disease. We present a case of a patient with CVID complicated by rhinosinusitis with granulomatous inflammation. Treatment for this patient was challenging with regards recognition of the granulomatous manifestation as well as treatment in the setting immunodeficiency and was ultimately unsuccessful. Read More

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Primary tuberculosis of the pyriform sinus: A case report.

Ann Med Surg (Lond) 2022 Apr 14;76:103436. Epub 2022 Mar 14.

Department of Otorhinolaryngology -Head and neck surgery, University Hospital of Tangier-Tetouan-Al Hoceima, Morocco.

Introduction: Tuberculosis is a chronic bacterial infection caused by the . Extrapulmonary tuberculosis (EPTB) accounts for about 20% of cases in immunocompetent patients and 50% of cases in HIV-positive individuals (7). Except for the cervical lymph nodes location, head and neck tuberculosis is rare. Read More

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Tuberculous Abscesses in the Head and Neck Region.

Diagnostics (Basel) 2022 Mar 11;12(3). Epub 2022 Mar 11.

Department of Otorhinolaryngology, Vienna General Hospital, Medical University of Vienna, 1090 Vienna, Austria.

Tuberculosis represents a global health challenge and is one of the leading infectious killers, with over a million people succumbing to it every year. While the disease is primarily prevalent in developing countries, where 95% of cases and deaths occur, doctors around the globe need to be able to recognize its diverse clinical manifestations in order to initiate appropriate treatment early. The granulomatous infection caused by typically affects the lungs, but isolated abscesses in the head and neck region can be a less common presentation of the disease, potentially resulting in dysphagia, odynophagia, voice changes, neck swelling, bone erosion, and even life-threatening respiratory distress requiring tracheostomy. Read More

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Duodenal gastrointestinal stromal tumour imitating as pancreatic head tumour.

BMJ Case Rep 2022 Mar 1;15(3). Epub 2022 Mar 1.

Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Duodenal gastrointestinal stromal tumours (D-GISTs) are a rare disease. It may arise commonly from the second or third part of the duodenum and can be erroneously diagnosed as a pancreatic head tumour due to proximity and morphology on imaging studies. We present a case of a 60-year-old woman who presented with abdominal pain and was diagnosed as a case of pancreatic neuroendocrine tumour on radiologic imaging and granulomatous lesion on aspiration cytology. Read More

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Imaging features of F-FDG PET/CT in different types of systemic vasculitis.

Clin Rheumatol 2022 May 28;41(5):1499-1509. Epub 2022 Jan 28.

Department of Rheumatology and Immunology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Objective: To analyze F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) image features in different types of systemic vasculitis and explore its classification and diagnostic significance for systemic vasculitis.

Methods: Clinical and F-FDG PET/CT imaging data of 71 consecutive patients (34 males, 37 females, mean age 53.4 ± 20. Read More

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Chronic Laryngotracheal Granulomatous Disease Secondary to in an Immunocompromised Patient.

Ann Otol Rhinol Laryngol 2022 Jan 11:34894211073002. Epub 2022 Jan 11.

Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, VA, USA.

Objective: To describe a rare presentation of laryngotracheal granulomatous disease secondary to sporotrichosis.

Methods: The authors report a case of laryngeal sporotrichosis in an immunocompromised patient, with accompanying endoscopic images and pathology.

Results/case: A 72-year-old immunocompromised female with a history of rose-handling presented with a year of hoarseness and breathy voice. Read More

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January 2022

Persistent Inflammation and Nitric Oxide Dysregulation Are Transcriptomic Blueprints of Subglottic Stenosis.

Front Immunol 2021 20;12:748533. Epub 2021 Dec 20.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States.

Subglottic stenosis (SGS) is a recurrent, obstructive, fibroinflammatory disease of the upper airway resulting in severe dyspnea, dysphonia, as well as other potentially fatal complications. Although aberrant inflammation and wound-healing are commonly associated with pathogenesis, the mechanism through which such processes occur and recur in affected patients remains poorly studied. Here we report that transcriptomic profiling of laryngotracheal regions from minimally-invasive mucosal swabs of SGS patients reveals a distinctively pro-inflammatory gene signature. Read More

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February 2022

"Chronic granulomatous invasive fungal rhinosinusitis associated with SARS-CoV-2 infection: A case report".

Ann Med Surg (Lond) 2021 Dec 2;72:103129. Epub 2021 Dec 2.

Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital "Dr. Jose E. González", Universidad Autónoma de Nuevo León, Dr. José Eleuterio González (Gonzalitos) S/N, Mitras Centro, 64460, Monterrey, N.L., Mexico.

Introduction And Importance: Granulomatous chronic invasive fungal rhinosinusitis (GCIFR) is a rare entity with scarce cases reported mainly in subtropical areas. Its prevalence among individuals with clinical suspicion of fungal rhinosinusitis has been reported in approximately 20% in subtropical populations, unlike North America with a prevalence of 0.5%. Read More

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December 2021

Leprosy of the great auricular nerve: case report and review of the literature.

Clin Imaging 2022 Feb 15;82:63-66. Epub 2021 Oct 15.

Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Infection Disease, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

We report clinical, imaging and pathology findings of a patient with leprosy of the great auricular nerve who presented with palpable nodules and numbness of the left ear and scalp. Ultrasound and contrast-enhanced CT imaging of the neck demonstrated diffuse enlargement and enhancement of the great auricular nerve. Biopsy of the enlarged left great auricular nerve revealed granulomatous inflammation with necrosis involving the nerve with rare Fite-positive organisms compatible with mycobacterium. Read More

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February 2022

[Sarcoidosis in head and neck area - a diagnostic challenge using the example of skin manifestations].

Laryngorhinootologie 2022 Jul 11;101(7):585-591. Epub 2021 Nov 11.

Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Bonn.

Background:  Sarcoidosis is a granulomatous multisystem disease of unknown etiology and relatively rare. The heterogeneous clinical picture is a diagnostic challenge. We are investigating whether the superficially visible cutaneous lesions can lead to the differential diagnosis of sarcoidosis and what systemic manifestations are present. Read More

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Retroanalytical Study of Epidemiological Factors of Rhinosporidiosis.

Int Arch Otorhinolaryngol 2021 Oct 30;25(4):e504-e508. Epub 2020 Nov 30.

Department of ENT & HNS, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

 Rhinosporidiosis is a granulomatous disease of humans and animals that is caused by . This disease is endemic in certain states of India, like Chhattisgarh, Tamil Nadu, Kerala, Orissa, and eastern Madhya Pradesh. We conducted a retrospective, record-based study in the department of ENT & Head and Neck Surgery of a tertiary case institute in Chhattisgarh. Read More

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October 2021

Surgical management of parotid non-tuberculous mycobacteria lymphadenitis in children: A pediatric tertiary-care hospital's experience.

Int J Pediatr Otorhinolaryngol 2021 Dec 27;151:110960. Epub 2021 Oct 27.

Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Otolaryngology Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Objective: Non-tuberculous mycobacteria (NTM) represents an important etiology of cervicofacial lymphadenitis (CFL) and skin/soft tissue infections in children. It can also affect the salivary glands, including the parotid gland, which is unique due to the presence of intra-salivary lymph nodes. There are no established guidelines for treatment of NTM CFL. Read More

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December 2021

Analysis of pathogens and antimicrobial treatment in different groups of patients with chronic otitis media.

J Laryngol Otol 2022 Mar 27;136(3):219-222. Epub 2021 Oct 27.

Department of Microbiology, Faculty of Pharmacy, Collegium Medicum Nicolaus Copernicus University, Bydgoszcz, Poland.

Objective: Microbial infection plays an important role in exacerbation of chronic otitis media. The aim of this study was to analyse the microbiota in chronic otitis media in the context of local treatment.

Method: In this prospective study, samples for microbiological examination were taken from 119 patients who underwent operation because of chronic otitis media. Read More

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Mimics of perineural tumor spread in the head and neck.

Br J Radiol 2021 Dec 7;94(1128):20210099. Epub 2021 Sep 7.

Section of Neuroradiology, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Perineural spread (PNS) is an important potential complication of head and neck malignancy, as it is associated with decreased survival and a higher risk of local recurrence and metastasis. There are many review articles focused on the imaging findings of PNS. However, a false-positive diagnosis of PNS can be just as harmful to the patient as an overlooked case. Read More

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December 2021

Concurrent diagnosis of sinus fungus ball and invasive fungal sinusitis: A retrospective case series.

Mycoses 2021 Sep 5;64(9):1117-1123. Epub 2021 Jul 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Sinus fungal ball (SFB) is the most common type of non-invasive fungal sinusitis and develops mostly in immunocompetent individuals, whereas invasive fungal sinusitis (IFS), with high mortality, develops mostly in immunocompromised patients. SFB may progress to IFS depending on the patient's immune status and underlying diseases.

Objectives: To investigate the possibility of SFB progressing to IFS. Read More

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September 2021

Laryngeal Sarcoidosis and Swallowing: What Do We Know About Dysphagia Assessment and Management in this Population?

Dysphagia 2022 06 26;37(3):548-557. Epub 2021 May 26.

Department of Otolaryngology, Head and Neck Surgery, National Centre for Airway Reconstruction, Imperial College Healthcare NHS Trust, London, UK.

Introduction: Sarcoidosis is a chronic granulomatous disease of unknown aetiology and laryngeal involvement is seen in a small percentage of cases. Dysphagia is a common but under-reported symptom. Little is known about how dysphagia typically presents or is managed in the context of this fluctuating disease. Read More

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Nasal-type extranodal NK/T-cell lymphoma presenting as recurrent periorbital cellulitis.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Otolaryngology, Tallaght University Hospital, Dublin, Dublin, Ireland.

Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) is a rare disease with a poor prognosis. It has features similar to other granulomatous and infectious diseases of the nose and paranasal sinuses, which can make diagnosis challenging and delayed. We present a case of 38-year-old man who was admitted to the hospital on three occasions over a 3-month period for right periorbital erythema, nasal congestion and discharge. Read More

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Invasive, aggressive mastoid bone eumycetoma: a treatment challenge.

Trans R Soc Trop Med Hyg 2021 04;115(4):431-435

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a chronic granulomatous disease that significant affects the subcutaneous tissue and deep structures. Mycetoma is caused by certain fungi (eumycetoma) or higher bacteria (actinomycetoma). The clinical presentation is variable and depends on the causative agent. Read More

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Managing a Complicated Acute Otomastoiditis at Day Four of Life.

Cureus 2021 Jan 25;13(1):e12905. Epub 2021 Jan 25.

Otolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Acute mastoiditis in a newborn complicated by the presence of facial nerve palsy is an alarming finding requiring rapid assessment and further investigation. Such an early presentation should point the clinician towards an underlying systemic pathology or congenital anatomical abnormality. Facial nerve involvement indicates severe infection and possible dehiscence of the facial canal. Read More

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January 2021

Tolosa-Hunt Syndrome Misdiagnosed as Surgical Complication After Frontal Balloon Sinuplasty.

J Craniofac Surg 2021 Sep;32(6):e534-e535

Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine.

Abstract: Tolosa-Hunt syndrome (THS) is a rare benign disease caused by granulomatous inflammation in the craniofacial region. It is mostly idiopathic and generally presents with painful ophthalmoplegia, ipsilateral oculomotor paresis, and steroid responsiveness. There are few reports of THS after sinus surgery. Read More

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September 2021

Foreign body reaction toward hydrophilic polymer at the site of endovascular procedure: A report of two cases.

J Cutan Pathol 2021 Jun 11;48(6):781-784. Epub 2021 Feb 11.

Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.

Hydrophilic polymer-coated devices have been increasingly utilized for various endovascular procedures, however not been without adverse effects. We report two cases of subacute cutaneous lesions on the neck encountered in our dermatology clinic. Histopathologic findings were significant for a nodular aggregate of epithelioid histiocytes and lymphocytes with numerous foreign body giant cells in the dermis. Read More

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Extensive bony sarcoidosis of the head and neck region: a rare presentation.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Oral and Maxillofacial Surgery, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, Derbyshire, UK.

We present a rare case of sarcoidosis with extensive bony destruction of the maxillofacial and skull base bones. A 65-year-old woman was referred with an asymptomatic, non-healing dental socket. Examination revealed an oroantral fistula that was biopsied and repaired under general anaesthesia. Read More

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January 2021

An uncommon case of lip swelling: Granulomatous cheilitis associated with Crohn's disease.

Am J Otolaryngol 2021 Mar-Apr;42(2):102897. Epub 2021 Jan 4.

Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh School of Medicine, United States of America. Electronic address:

Unbeknownst to most otolaryngologists, there is quite a range of oral manifestations which commonly manifest in the context of inflammatory bowel disease. As providers who will encounter such patients in consultation it is beneficial to be aware of that association. Lip swelling (granulomatous cheilitis) is just one such presentation, which is often otherwise mistaken for angioneurotic edema and can lead to unwarranted testing and misdirected treatment. Read More

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September 2021

Diagnostic performance of EBUS-TBNA and its interrelation with PET-CT in patients with extra-thoracic malignancies.

Tuberk Toraks 2020 Sep;68(3):285-292

Department of Chest Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic tool for lung cancer, sarcoidosis, and suspected metastatic extra-thoracic malignancy (ETM). Patients with primary ETM often have hypermetabolic mediastinal/hilar lymph node enlargement in the PET-scan done for initial staging or post treatment followup. We aimed to determine the diagnostic performance of EBUS-TBNA and the relationship between PET-SUV values and diagnosis of malignancy metastasis in patients with ETM. Read More

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September 2020

Parotitis caused by Mycobacteroides abscessus subspecies abscessus.

Auris Nasus Larynx 2022 Jun 24;49(3):525-528. Epub 2020 Nov 24.

Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Rapidly growing mycobacteria rarely causes parotitis. We report a rare case of Mycobacteroides abscessus subspecies abscessus (MAB) parotitis in a previously healthy 26-year-old woman. She presented to the previous hospital with a swelling over the right parotid region, and a computed tomography scan revealed multiple abscesses in the swollen parotid gland. Read More

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Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient.

Ear Nose Throat J 2020 Nov 25:145561320973772. Epub 2020 Nov 25.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, 5232University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

A 12-year-old male with a family history of inflammatory bowel disease presented with sleep-disordered breathing and was found to have chronic, granulomatous swelling of the supraglottic larynx. His airway was managed with tracheostomy, regular interval laryngeal steroid injections, supraglottoplasty, and "pepper pot" CO2 laser resurfacing leading to eventual decannulation. Due to the non-necrotic nature of the granulomatous inflammation, as well as the patient's family history of inflammatory bowel disease, the leading diagnosis was Crohn disease, but isolated laryngeal sarcoidosis could not be ruled out. Read More

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November 2020

A rare case of pediatric Crohn's disease and alveolar bone loss: a report and review.

Transl Pediatr 2020 Oct;9(5):720-725

Department of Stomatology, the Children's Hospital, Zhejiang University School of Medicine, National Clinic Research Center for Child Health, Hangzhou, China.

Crohn's disease (CD) is a granulomatous inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, but its etiology is still unclear. CD patients usually have extraintestinal manifestations including oral manifestations, and this can also occasionally appear in children. Oral manifestations, including aphthous stomatitis, typically develop on the mucocutaneous tissue. Read More

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October 2020