26,719 results match your criteria Granulomatous Diseases of the Head and Neck


An Unusual Presentation of Lupus Vulgaris and the Practical Usefulness of Dermatoscopy.

Case Rep Dermatol Med 2018 14;2018:1036162. Epub 2018 Nov 14.

Specialist in Dermatology-Venereology, Chief of State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Delfon 124, 54643 Thessaloniki, Greece.

We report a case report of lupus vulgaris (LV) presented on the extremities of an 80-year-old man. He was misdiagnosed as having psoriasis and referred to our department for a second-opinion evaluation. The discrepancy between the clinical manifestation which was misleading and the dermatoscopic findings raised the suspicion of an underlying granulomatous disease and we proceeded to skin biopsy. Read More

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November 2018
1 Read

A patient with Wegener's granulomatosis in apparent remission presenting with complete atrioventricular block.

J Cardiol Cases 2011 Apr 20;3(2):e71-e74. Epub 2011 Feb 20.

Department of Cardiology, Royal Blackburn Hospital, Haslingden Road, Blackburn BB2 3HH, United Kingdom.

Wegener's granulomatosis is a systemic necrotizing granulomatous vasculitis of small- to medium-sized vessels typically affecting upper and lower airways, lungs, and kidneys. Cardiac involvement is less common and conducting tissue involvement is extremely rare. Cardiac manifestations are often not clinically apparent, but are associated with increased mortality. Read More

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April 2011
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Whole-Genome Sequences of Propionibacterium australiense NML (LCDC) 98A072 and NML (LCDC) 98A078, Associated with Granulomatous Bovine Lesions.

Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.

National Microbiology Laboratory (NML)-CSCHAH Site, Public Health Agency of Canada, Winnipeg, Canada.

Draft genome sequences of Propionibacterium australiense isolates NML 98A072 and NML 98A078, derived from granulomatous lesions of infected bovines, were assembled and studied. Respectively, the genome sizes were 2.99 and 3. Read More

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November 2018

Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis.

Case Rep Med 2018 5;2018:4628439. Epub 2018 Nov 5.

Texas A&M University, College Station, TX, USA.

Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by presence of noncaseating granulomas in the involved organs. The pulmonary interstitium is most commonly affected but extrapulmonary involvement can occur in almost any other organ system. Such an involvement can occur with or without the presence of pulmonary involvement, but isolated extrapulmonary involvement has been noted only in around 10% of cases. Read More

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November 2018

Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis.

Authors:
Adilia Warris

Pediatr Infect Dis J 2018 Dec 10. Epub 2018 Dec 10.

MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.

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December 2018

Two atypical presentations of lepra reactions.

Int J Mycobacteriol 2018 Oct-Dec;7(4):390-393

Army College of Medical Sciences, New Delhi, India.

Leprosy or Hansen's disease is a chronic infectious granulomatous disease with varied presentation, especially in the setting of lepra reactions. We report two such atypical presentations each of Type I and Type II Lepra reactions; the first being an elderly male presenting with fever, while the second case being of a young boy being evaluated for cervical lymphadenitis. Read More

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December 2018

Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases.

J Autoimmun 2018 Oct 24. Epub 2018 Oct 24.

Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Objective: To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM).

Methods: We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982-2017). 13/191 patients presented with a TLM. Read More

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October 2018

Long-Term Outcome in Probable Versus Absolute Cardiac Sarcoidosis.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland.

Suspicion of cardiac sarcoidosis (CS) arises when a patient has clinical cardiac manifestations and findings on cardiac imaging suggestive of inflammatory cardiomyopathy with or without history of extracardiac sarcoidosis. The additional requirement for diagnosis is proof of sarcoidosis histology. Endomyocardial biopsy (EMB) showing granulomatous inflammation in absence of other explanations confirms an absolute diagnosis of CS while similar histology in an extracardiac biopsy gives a probable diagnosis of CS. Read More

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November 2018
1 Read

Atypical presentation of necrobiosis lipoidica in a pediatric patient.

Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Dermatology Department, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Necrobiosis lipoidica (NL) is a rare chronic granulomatous inflammatory skin disease characterized by brownish-red papules and yellowish plaques with atrophic centers, which usually affect the legs, bilaterally. The average age of onset is 30-40 years, and there are very few reported cases of necrobiosis lipoidica in children. A nondiabetic girl aged 14 years presented to our clinic with a history of an asymptomatic, 7 × 5-cm single red plaque over her back in the interscapular area, which had started 5 years ago. Read More

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December 2018
4 Reads

Chronic granulamatous disease: two decades of experience from a pediatric immunology unit in a country with high rate of consangineous marriages.

Scand J Immunol 2018 Dec 1:e12737. Epub 2018 Dec 1.

Ege University, Faculty of Medicine, Department of Pediatric Immunology, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by susceptibility to bacterial and fungal infections resulting from the inadequacy of phagocytic leukocytes to produce reactive oxygen radicals. CGD is a genetically heterogeneous disease with an X-linked recessive (XR-CGD) form caused by mutations in the CYBB (OMIM #300481) gene encoding the gp91(phox) protein, and an autosomal recessive (AR-CGD) form caused by mutations in the CYBA (OMIM #608508), NCF1 (OMIM #608512), NCF2 (OMIM #608515) and NCF4 (OMIM #601488) genes encoding p22(phox), p47(phox), p67(phox), and p40(phox), respectively. The genetic mutation of one of the cytosolic p47phox/p67phox proteins and membrane-bound gp91phox/p22phox proteins, which constitutes the NADPH oxidase enzyme complex, causes the disease. Read More

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December 2018
1 Read

Aggressive granulomatosis of the hip: a forgotten mode of aseptic failure.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Hip Surgery Unit, Italian Hospital of Buenos Aires, Institute of Orthopaedics "Carlos E. Ottolenghi", 4247 Potosí St, C1199ACK, Buenos Aires, Argentina.

Purpose: It has been acknowledged that implant wear correlates with the risk for periprosthetic osteolysis, being aggressive granulomatosis the worst expression of bone resorption. We sought to determine the clinical, radiological, and histological features of aggressive granulomatosis after primary total hip arthroplasty (THA).

Methods: We included nine cases with aggressive granulomatosis of the hip around cemented stems. Read More

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November 2018
1 Read

Management of broncholithiasis.

J Thorac Dis 2018 Oct;10(Suppl 28):S3419-S3427

Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Broncholithiasis is a condition in which calcified material has entered the tracheobronchial tree, at times causing airway obstruction and inflammation. Broncholiths generally originate as calcified material in mediastinal lymph nodes that subsequently erode into adjacent airways, often as a result of prior granulomatous infection. Disease manifestations range from asymptomatic stones in the airway to life-threatening complications, including massive hemoptysis and post-obstructive pneumonia. Read More

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October 2018
3 Reads

Epidermotropism in Nodular Secondary Syphilis.

Indian J Dermatol 2018 Nov-Dec;63(6):509-511

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

Nodular secondary syphilis results from the hematogenous and lymphatic dissemination of spirochetes. Clinically, the lesions appear as partially infiltrated plaques or red-violaceous nodules, which can be solitary or multiple. Several hypotheses have been put forward to explain the formation of these infiltrated or granulomatous lesions. Read More

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December 2018

Palisaded Neutrophilic Granulomatous Dermatoses: An Unusual Lesion Affecting the Palms.

J Rheumatol 2018 Dec;45(12):1706-1707

Rheumatology, University of British Columbia, British Columbia, Canada.

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December 2018
1 Read

Mycobacterium genavense Infection in a Domestic Ferret (Mustela putorius furo).

Top Companion Anim Med 2018 Dec 10;33(4):119-121. Epub 2018 Oct 10.

Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), 25124 Brescia, Italy.

Mycobacterium genavense infection was diagnosed in an adult ferret with ptosis of the left eye, a proliferative lesion of the conjunctiva of the nictitating membrane, conjunctival swelling, and tumefaction of the periorbital tissues with a watery ocular discharge and the presence of a retrobulbar mass. The diagnosis was based on characteristic cytology of the retrobulbar mass and left mandibular lymph node that revealed granulomatous inflammation. Ziehl-Neelsen staining showed the presence of positive acid-fast bacilli in the cytoplasm of the macrophages. Read More

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December 2018
1 Read

Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs.

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine and Epidemiology, Veterinary Medical Teaching Hospital, University of California-Davis School of Veterinary Medicine, California.

Background: Proliferative urethritis (PU) is a lower urinary tract disease of dogs characterized by frond-like lesions in the urethra. The etiology of PU is unknown, although an association with bacterial cystitis is reported.

Objectives: Deep-seated bacterial cystitis is associated with PU, particularly in dogs with neutrophilic or granulomatous inflammation. Read More

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December 2018
1 Read

Second-harmonic generation imaging analysis can help distinguish sarcoidosis from tuberculoid leprosy.

J Biomed Opt 2018 Dec;23(12):1-7

Technology on Photonics Applied to Cell Biology, Campinas, Brazil.

Sarcoidosis and tuberculoid leprosy (TL) are prototypes of granulomatous inflammation in dermatology, which embody one of the histopathology limitations in distinguishing some diseases. Recent advances in the use of nonlinear optical microscopy in skin have enabled techniques, such as second-harmonic generation (SHG), to become powerful tools to study the physical and biochemical properties of skin. We use SHG images to analyze the collagen network, to distinguish differences between sarcoidosis and TL granulomas. Read More

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December 2018
3 Reads
2.859 Impact Factor

Bartonella infections in cats and dogs including zoonotic aspects.

Parasit Vectors 2018 Dec 4;11(1):624. Epub 2018 Dec 4.

Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

Bartonellosis is a vector-borne zoonotic disease with worldwide distribution that can infect humans and a large number of mammals including small companion animals (cats and dogs). In recent years, an increasing number of studies from around the world have reported Bartonella infections, although publications have predominantly focused on the North American perspective. Currently, clinico-pathological data from Europe are more limited, suggesting that bartonellosis may be an infrequent or underdiagnosed infectious disease in cats and dogs. Read More

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December 2018
1 Read

Systemic Dissemination of Injected Foreign Material.

J Forensic Sci 2018 Dec 4. Epub 2018 Dec 4.

Forensic Science SA, GPO Box 2790, Adelaide, 5001.

A 32-year-old woman collapsed following an intravenous injection of material that included crushed pharmaceutical tablets. Resuscitation was attempted but was unsuccessful. She had an extensive past medical history of complications resulting from intravenous drug use. Read More

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December 2018
3 Reads

A case of Brucella aortitis associated with development of thoracic aortic aneurysm and aortobronchial fistula.

Cardiovasc Pathol 2018 Nov 7;39:5-7. Epub 2018 Nov 7.

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston/Memorial Hermann Hospital-Texas Medical Center, 6431 Fannin St, Houston, TX 77030, USA. Electronic address:

Objectives: The purpose of this case report is to document the occurrence of granulomatous aortitis complicated by formation of a saccular aneurysm and aortobronchial fistula due to Brucella infection.

Methods: A 65-year-old man with a history of feral swine hunting presented with hemoptysis and was found to have a saccular thoracic aortic aneurysm and associated aortobronchial fistula. The aneurysm underwent operative repair with closure of the aortobronchial fistula. Read More

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November 2018
2 Reads

Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child.

Turk J Pediatr 2018 ;60(3):340-343

Division of Infectious Diseases, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.

Sütçü M, Aktürk H, Gülümser-Şişko S, Acar M, Erol OB, Somer A, Bilgiç B, Salman N. Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child. Turk J Pediatr 2018; 60: 340-343. Read More

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January 2018
1 Read

Diagnostic histochemistry in non-neoplastic skin diseases.

Semin Diagn Pathol 2018 Nov 16;35(6):390-398. Epub 2018 Oct 16.

PRW Laboratories, Charlottesville, VA, USA.

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. Read More

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November 2018
2 Reads

[CVID is a multifaceted disease].

Ugeskr Laeger 2018 Nov;180(47)

Common variable immunodeficiency disease (CVID) is the most common primary immunodeficiency in adults, and multiple organs may be involved. This is a case report of a 49-year-old female patient with granulomatous-lymphocytic interstitial lung disease, liver fibrosis, portal hypertension and rectal cancer. Examinations showed non-necrotic granulomas in her lungs, mediastinal glands and liver, and she was seen in six different specialities. Read More

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November 2018
2 Reads

[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement].

Vestn Oftalmol 2018 ;134(5):32-38

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283.

Eye lesion in sarcoidosis is often the first and only sign of a disorder, which suggests a possible systemic disease. Currently sarcoidosis is considered a multisystemic granulomatous disease that requires multidisciplinary approach.

Purpose: To study the prevalence and clinical aspects of sarcoidosis eyes based on the representative sample of patients diagnosed with extraocular nonspecific granulomatous disease. Read More

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January 2018
4 Reads

Hepatic leptospiral infections in dogs without obvious renal involvement.

J Vet Intern Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

Background: Reports of chronic hepatitis in dogs caused by Leptospira spp. are confined to small case series. Fluorescence in situ hybridization (FISH) allows the identification of spirochetes in liver samples. Read More

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November 2018
3 Reads

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients.

Breast Care (Basel) 2018 Oct 5;13(5):359-363. Epub 2018 Jul 5.

Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong, China.

Background: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome.

Methods: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Read More

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October 2018
3 Reads

A rare case report of polyangiitis overlap syndrome: granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis.

BMC Pulm Med 2018 Nov 29;18(1):181. Epub 2018 Nov 29.

Department of Pulmonary, Critical Care, Hyperbaric and Sleep Medicine, Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA, 92354, USA.

Background: Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophilic granulomatosis with polyangiitis (EGPA) is also a systemic ANCA-associated vasculitis, but EGPA is characterized by eosinophilic as well as granulomatous inflammation and is more commonly associated with asthma and eosinophilia. Polyangiitis overlap syndrome is defined as systemic vasculitis that does not fit precisely into a single category of classical vasculitis classification and/or overlaps with more than one category. Read More

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November 2018
2 Reads

Coryneform Bacteria in Granulomatous Lobular Mastitis: Morphological Diagnosis in Breast Biopsies.

Int J Surg Pathol 2018 Nov 29:1066896918815580. Epub 2018 Nov 29.

1 Pontificia Universidad Católica de Chile, Santiago, Chile.

Granulomatous lobular mastitis is a rare disease whose origin is still unknown and shows an increase in its frequency. Morphological, microbiological, and molecular biology studies have linked this disease to lipophilic and fastidious corynebacteria, suggesting its possible infectious etiology. This series describes and reviews in detail the distinctive morphological characteristics of the bacteria present in the granulomas of this disease, the usefulness of histochemical techniques for their identification, and our proposal for a tissue quantification score for the bacteria. Read More

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November 2018
1 Read
0.961 Impact Factor

Magnetic resonance perfusion and diffusion characteristics of granulomatous diseases mimic those of malignant lesions: six case reports.

Oral Radiol 2018 Jan 16;34(1):73-82. Epub 2017 Mar 16.

Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki, 852-8588, Japan.

The perfusion and diffusion properties of a tumor are important clues in evaluating its growth potential and predicting its histological type, such as benign or malignant. Tumor perfusion can be estimated by assessing time-dependent changes in the intratumoral levels of the contrast agent during dynamic contrast-enhanced magnetic resonance (MR) imaging, whereas tumor diffusion can be estimated by assessing intratumoral water diffusivity on diffusion-weighted MR imaging. Granulomatous diseases with different etiologies occur in various head and neck regions, including the mandible, maxillary sinus, salivary glands, and lymph nodes. Read More

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January 2018
1 Read

Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype.

Front Immunol 2018 12;9:2580. Epub 2018 Nov 12.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.

Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth , but the transcriptional changes that underlie this effect are poorly understood. To explore this, we sorted the two previously recognized hepatic macrophage populations (perivascular and Kupffer cells) from naïve and -infected male mice and performed microarray analysis as part of the Immunological Genome Project. The two hepatic macrophage populations exhibited remarkably different genomic profiles. Read More

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November 2018
1 Read

Human Chronic Necrotizing Granulomatous Meningoencephalitis: A Novel Case Report.

Case Rep Neurol 2018 Sep-Dec;10(3):302-308. Epub 2018 Oct 24.

Geisinger Medical Center, Danville, Pennsylvania, USA.

Necrotizing and granulomatous meningoencephalitis are common central nervous system diseases known to affect canines. To date, necrotizing granulomatous meningoencephalitis has yet to be described in humans. Current studies of presumed pathogenesis and possible treatment options have only been described in canines. Read More

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October 2018
3 Reads

Long-term use of Le Fort I osteotomy for the management of nasopharyngeal rhinosporidiosis: A case series.

Ear Nose Throat J 2018 Oct-Nov;97(10-11):E36-E43

Department of Craniofacial Surgery, Nitte Meenakshi Institute of Craniofacial Surgery, Deralakatte, Mangalore, Karnataka, India.

Rhinosporidiosis is a rare, chronic, granulomatous infection of the mucous membranes that mainly involves the nose and nasopharynx; it occasionally involves the pharynx, conjunctiva, larynx, trachea and, rarely, the skin. The characteristic clinical features of this disease include the formation of painless polyps in the nasal mucosa or the nasopharynx that bleed easily on touch. At our center, excision of the lesion with a Le Fort I osteotomy is carried out in patients (1) in whom two or more previous attempts at excision of biopsy-proven rhinosporidiosis arising from the nasal mucosa was carried out or (2) in whom the rhinosporidiosis arises from the nasophayrngeal mucosa and/or extranasal sites. Read More

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November 2018
2 Reads

Role of Ultrasound-Guided Fine-Needle Aspiration Cytology of Omentum in Diagnosis of Abdominal Tuberculosis.

Surg Infect (Larchmt) 2018 Nov 27. Epub 2018 Nov 27.

2 Department of Gastroenterology, Postgraduate Institute of Medical Education and Research , Chandigarh, India .

Aim: To evaluate the efficacy of ultrasound-guided (USG) fine-needle aspiration cytology examination (FNAC) of the omentum in the diagnosis of abdominal tuberculosis (TB).

Methods: Retrospective review was conducted of data from patients who presented with clinically suspected peritoneal TB between June 2016 and April 2018. We included patients in whom imaging showed omental thickening with or without ascites. Read More

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November 2018
1 Read

Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities.

Ann Med Surg (Lond) 2018 Dec 9;36:162-167. Epub 2018 Nov 9.

Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Idiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory disease which can clinically and radiographically mimic abscess or breast cancer. Definitive diagnosis was made by histopathology and exclusion of an identifying etiology. Optimal treatment has not been yet established. Read More

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December 2018
1 Read

Sympathetic Ophthalmia: Experience from a Tertiary Care Center in Northern India.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):439-446

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To describe our clinical experience with sympathetic ophthalmia (SO) at a tertiary eye care center in north India.

Methods: In this retrospective case series, analysis of the clinical features and visual outcomes of patients diagnosed with SO between March 2012 and March 2016 were performed.

Results: Ten male and four female patients (median age, 15. Read More

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November 2018
1 Read

[Causes of mediastinal/hilar granulomatous lymphadenitis].

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

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September 2018
8 Reads

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii.

Parasit Vectors 2018 Nov 26;11(1):604. Epub 2018 Nov 26.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

Background: Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis. Cysteine biosynthesis and the L-serine metabolic pathway play important roles in the energy metabolism of Acanthamoeba spp. Read More

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November 2018
1 Read

Scalp Sarcoidosis Presenting as Cicatricial Alopecia.

J Am Osteopath Assoc 2018 Dec;118(12):824-826

Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. Read More

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December 2018
2 Reads

Approach to Molecular Diagnosis of Chronic Granulomatous Disease (CGD): an Experience from a Large Cohort of 90 Indian Patients.

J Clin Immunol 2018 Nov 23. Epub 2018 Nov 23.

National Institute of Immunohaematology-ICMR, 13th floor, KEM Hospital Campus, Mumbai, Parel, 400012, India.

Background: Chronic granulomatous disease (CGD) is characterized by mutation in any one of the five genes coding NADPH oxidase components that leads to functional abnormality preventing the killing of phagocytosed microbes by affecting the progression of a respiratory burst. CGD patients have an increased susceptibility to infections by opportunistic and pathogenic organisms. Though initial diagnosis of CGD using a nitroblue tetrazolium (NBT) test or dihydrorhodamine (DHR) test is relatively easy, molecular diagnosis is challenging due to involvement of multiple genes, presence of pseudogenes, large deletions, and GC-rich regions, among other factors. Read More

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November 2018
4 Reads

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

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November 2018
6 Reads

Advances in Inflammatory Granulomatous Skin Diseases.

Dermatol Clin 2019 Jan;37(1):49-64

Dermatology Administration, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 7th Floor, South Tower, Philadelphia, PA 19104, USA. Electronic address:

Inflammatory granulomatous dermatitides include cutaneous sarcoidosis, necrobiosis lipoidica, granuloma annulare, and reactive granulomatous dermatitis. The etiopathogenesis of these disorders is not well understood; but the T helper 1 response mediated by interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL) 1, 2, and 6 and the T helper 17 response mediated by IL-17 play a role. These inflammatory granulomatous disorders often have cutaneous manifestations in addition to extracutaneous manifestations or associations with systemic diseases. Read More

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January 2019
7 Reads

[Chronic granulomatous disease as a rare differential diagnosis of inflammatory bowel disease].

Z Gastroenterol 2018 Dec 22;56(12):1507-1512. Epub 2018 Nov 22.

I. Medizinische Klinik und Poliklinik, Gastroenterologie und Hepatologie, Universitätsmedizin Mainz.

Background:  Chronic granulomatous disease is a rare disease with a prevalence of approximately 150 cases in Germany. An intestinal manifestation that mimics chronic inflammatory bowel disease (IBD) has only been described in a few cases. As a result of a deficient superoxide-synthesis, frequent and recurrent infections caused by rare pathogens have been described. Read More

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December 2018
1 Read

CBNAAT: A Boon for Early Diagnosis of Tuberculosis-Head and Neck.

Indian J Otolaryngol Head Neck Surg 2018 Dec 16;70(4):572-577. Epub 2018 Apr 16.

Department of Otorhinolaryngology, NSCB Medical College and Hospital, Jabalpur, 482003 India.

Tuberculosis of head and neck has been an under diagnosed entity due to large number of smear negative cases, which results in missing out the positive cases, further increasing the burden of TB. The role of cartridge- based nucleic acid amplification test (CBNAAT) with a potential to diagnose TB and rifampicin resistance within 2 h is promising. The study highlights the extended implications of CBNAAT in infectious lesions of head and neck, where the pus or aspirate was subjected to this test, along with other investigations which have been routinely used for detection of extra pulmonary tuberculosis. Read More

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December 2018
8 Reads

Performance of a bioglass-based dentine desensitizer under lactid acid exposition: an in-vitro study.

BMC Oral Health 2018 Nov 21;18(1):193. Epub 2018 Nov 21.

Clinic for Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Plattenstr. 11, 8032, Zurich, Switzerland.

Background: Dentine hypersensitivity is especially frequent in patients with pronounced periodontal attachment loss. Aim of the treatment is an obstruction of the dentine tubules in order to inhibit liquid or osmotic motion, which is considered as trigger for pain sensations. Novel approaches aim for obstruction by calcium phosphate compounds in order to rely on biocompatible compounds. Read More

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November 2018
1 Read

Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study.

Dermatology 2018 Nov 21:1-7. Epub 2018 Nov 21.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More

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November 2018
8 Reads

Superficial granulomatous pyoderma in a patient with ulcerative colitis successfully treated with cyclosporine A.

Int J Dermatol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.

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November 2018
1 Read

Granulomatous reaction on a double-level cervical total disc arthroplasty : case report.

World Neurosurg 2018 Nov 17. Epub 2018 Nov 17.

Department of Neurosurgery, Saint-Luc Hospital, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

Background: Cervical Total Disc Arthroplasty (TDA) or cervical artificial disc replacement (C-ADR) is an alternative technique to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic degenerative cervical spine disease. The main goal of TDA is to maintain cervical motion and therefore lower the risk of adjacent levels' deterioration. Granuloma formation on a cervical TDA is exceptional. Read More

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November 2018
4 Reads

[Chronic granulomatous disease: multiple infections as clinical presentation. Pediatric case report].

Arch Argent Pediatr 2018 Dec;116(6):e744-e748

Servicio de Infectología, Hospital de Niños Sor María Ludovica.

Chronic granulomatous disease is an uncommon primary immunodeficiency due to a defect of the killing activity of phagocytes, caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system. The incidence is 1 in 250 000 live births. It can occur from infancy to adulthood, usually in children under 2 years. Read More

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December 2018
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Isolation of Burkholderia pseudomallei from a Pet Green Iguana, Belgium.

Emerg Infect Dis 2018 Dec;24(12):2331-2333

We isolated Burkholderia pseudomallei, the causative agent of melioidosis, from liver granulomas of a pet green iguana (Iguana iguana) in Belgium. This case highlights a risk for imported green iguanas acting as a reservoir for introduction of this high-threat, zoonotic pathogen into nonendemic regions. Read More

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December 2018
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