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MSMR 2021 12;28(12):22

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):393-395

Department of Dermatology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):215-217. Epub 2020 Jul 31.

Department of Dermatology, Venereology and Leprosy, Sree Mookambika Institute of Medical Sciences, Kanyakumari, Tamil Nadu, India.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):162-168. Epub 2020 Jul 31.

Department of Dermatology, B. J. Medical College, Ahmedabad, Gujarat, India.

Context: Sexually transmitted infections (STIs) have a well-established synergistic relationship with human immunodeficiency virus (HIV) infection. Coinfection with HIV and STI can increase the probability of HIV transmission to an uninfected partner by increasing HIV concentrations in genital lesions, genital secretions, or both. Concurrent HIV infection alters the natural history of the classic STIs. Read More

An Bras Dermatol 2020 Nov - Dec;95(6):675-683. Epub 2020 Sep 17.

Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Donovanosis is a chronic, progressive, and indolent bacterial disease that affects the skin and mucous membranes of the genital and perigenital regions, often associated with sexual transmission, and with low infectivity. The malignant transformation of donovanosis lesions occurs exceptionally, as is usually seen in long-term ulcerations. Read More

Am J Dermatopathol 2020 Mar;42(3):218-219

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma, Barcelona, Spain; and.

Sex Transm Infect 2020 12 19;96(8):596-600. Epub 2020 Feb 19.

STI Section, Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.

Objectives: We used an in-house molecular assay for the detection of in ulcer specimens collected over a 12-year surveillance period in order to determine whether a diagnosis of donovanosis could be ascribed to genital ulcer disease (GUD) of unknown aetiology in our setting.

Methods: Between 2007 and 2018, a total of 974 genital ulcer specimens with no previously identified sexually transmitted (STI) pathogens were selected from STI aetiological surveys conducted in all nine provinces of South Africa. Giemsa-stained ulcer smears from the same participants had previously been routinely analysed for the presence of typical Donovan bodies within large mononuclear cells. Read More

J Eur Acad Dermatol Venereol 2019 Dec 29;33(12):e438-e440. Epub 2019 Aug 29.

Dermatology Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

Hautarzt 2018 Nov;69(11):945-959

Department of Dermatology, Preah Kossamak-Hospital, BP 1006, Phnom Penh, Kambodscha.

Sexually transmitted infections (STI) are common all over the world and the incidence of chlamydia, gonorrhea, syphilis and trichomoniasis alone is estimated at 500 million/year. Of these infections 75% occur in tropical countries in Latin America, sub-Saharan Africa and South as well as Southeast Asia. The bacterial infections chancroid, lymphogranuloma venereum (LGV) and granuloma inguinale (GI, Donovanosis) are termed tropical STI. Read More

An Bras Dermatol 2018 Jul-Aug;93(4):592-594

Laboratory of Pathology, Santa Casa de São Paulo, São Paulo (SP), Brazil.

Donovanosis is a chronic infectious disease caused by the Gram-negative bacteria Klebsiella granulomatis, which mainly affects the skin and mucous membranes of the genital, perigenital, and inguinal regions. Also known as venereal granuloma or granuloma inguinale, it is endemic in tropical and subtropical regions of the globe and often associated with sexual transmission. We report the case of an 11-year-old female victim of chronic sexual abuse, who was diagnosed with donovanosis and presented a good therapeutic response to doxycycline. Read More

Int J STD AIDS 2018 09 10;29(10):946-948. Epub 2018 May 10.

3 The Northern Sexual Health, Contraception and HIV Service, The Hathersage Centre, Manchester, UK.

The objective of this guideline is to provide guidance for the diagnosis and management of donovanosis, a now rare sexually transmitted infection. This guidance is primarily for professionals working in UK Sexual Health services (although others may find it useful) and refers to the management of individuals presenting with possible symptoms of donovanosis who are over the age of 16. An updated literature review since the last Clinical Effectiveness Group (CEG) guideline produced for this condition in 2011 has shown few new developments. Read More

Indian J Dermatol 2017 Nov-Dec;62(6):630-634

Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Introduction: Treatment of sexually transmitted infections (STIs) has been made easy for field workers due to syndromic approach. The etiological agent responsible for different STI syndromes needs to be validated from time to time so as to guide the therapeutic regimen.

Aims And Objectives: The aim of this study was to evaluate the etiological agent for STI syndromes and correlate the syndromic diagnosis with etiological diagnosis. Read More

Skinmed 2017;15(1):73-75. Epub 2017 Feb 1.

Silver Oaks Multispecialty Hospital, Mohali, Punjab, India.

A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. Read More

J Clin Diagn Res 2016 Dec 1;10(12):PD05-PD06. Epub 2016 Dec 1.

Professor, Department of Surgery, Madurai Medical College , Madurai, Tamil Nadu, India .

Tuberculosis (TB) of penis is a very rare entity, even in developing countries. It may present as primary or secondary to Pulmonary TB (PTB). Penile TB mimics carcinoma penis, granulomatous penile ulcer, genital herpes simplex, granuloma inguinale and HIV infection. Read More

Semin Diagn Pathol 2017 May 14;34(3):301-311. Epub 2016 Dec 14.

Section of Dermatopathology, Division of Surgical & Cytological Pathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:

Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. Read More

Ann Dermatol Venereol 2016 Nov 20;143(11):767-769. Epub 2016 Oct 20.

Service de dermatologie, hôpital Saint-André, CHU, 1, rue Jean-Burguet, 33000 Bordeaux, France.

Ann Dermatol Venereol 2016 Nov 20;143(11):739-740. Epub 2016 Oct 20.

Centre clinique et biologique des MST, hôpital Saint-Louis, 42, rue Bichat, 75010 Paris, France.

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

School of Medicine, UC Davis.

Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. Read More

Int J STD AIDS 2017 03 20;28(4):411-414. Epub 2016 Aug 20.

1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Donovanosis is a rare, chronic and indolent sexually transmitted infection caused by Klebsiella granulomatis. The ulcers in donovanosis rarely undergo malignant transformation, which is usually seen in longstanding ulcers. We present a case of a 32-year-old male who presented with a two-month history of rapidly progressive, large, foul-smelling ulcers over the groin, distal penile shaft and scrotum. Read More

Ann Dermatol Venereol 2016 Nov 9;143(11):697-700. Epub 2016 May 9.

Service de dermatologie et de vénérologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon, France.

Introduction: Donovanosis (granuloma inguinale) is a bacterial infection caused by Klebsiella granulomatis that occurs mainly in the genital area and is primarily sexually transmitted; it is seen predominantly in the tropics. Herein, we report a case of the disease contracted in metropolitan France.

Patients And Methods: A 47-year-old man presented with painless ulceration of the glans, present for one month, with progressive extension; there was no history of any recent trip abroad. Read More

Dis Mon 2016 Aug 20;62(8):306-13. Epub 2016 Apr 20.

Int J STD AIDS 2016 07 15;27(8):605-7. Epub 2016 Feb 15.

Olafia Clinic, Oslo University Hospital, Institute of Medicine, University of Oslo, Norway.

Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis, though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb nov The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described - ulcerogranulomatous, hypertrophic, necrotic and sclerotic. Read More

Fed Regist 2016 Jan;81(16):4191-206

The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), is issuing this final rule (FR) to amend its regulations governing medical examinations that aliens must undergo before they may be admitted to the United States. Based on public comment received, HHS/CDC did not make changes from the NPRM published on June 23, 2015. Accordingly, this FR will: Revise the definition of communicable disease of public health significance by removing chancroid, granuloma inguinale, and lymphogranuloma venereum as inadmissible health-related conditions for aliens seeking admission to the United States; update the notification of the health-related grounds of inadmissibility to include proof of vaccinations to align with existing requirements established by the Immigration and Nationality Act (INA); revise the definitions and evaluation criteria for mental disorders, drug abuse and drug addiction; clarify and revise the evaluation requirements for tuberculosis; clarify and revise the process for the HHS/CDC-appointed medical review board that convenes to reexamine the determination of a Class A medical condition based on an appeal; and update the titles and designations of federal agencies within the text of the regulation. Read More

Commun Dis Intell Q Rep 2015 Dec 31;39(4):E584-9. Epub 2015 Dec 31.

Office of Health Protection, Australian Government Department of Health, Canberra, Australian Capital Territory.

Folia Med Cracov 2015 ;55(1):35-41

Department of Dermatology Jagiellonian University Medical College, Skawinska 8, Krakow, Poland.

We analyzed publications and articles in the PubMed database about the use of trimethoprim and sulfamethoxazole (TMP-SMX) in dermatology. Literature published in the English language, at least in the past two decades, was reviewed. Specific dermatologic indications for TMP-SMX are few but it is often used as the second- or third- line agent. Read More

Int Marit Health 2015 ;66(4):238-46

Head of Department of Epidemiology and Tropical Medicine, Military Institute of Medicine, Warsaw, Poland.

Sexually transmitted infections (STIs) are among the most common notifiable health problems worldwide, with particularly high rates in developing countries. Men and women with multiple sexual partners at home or a previous history of STIs are more likely to have casual sexual exposure (CSE) while travelling. Over the last several decades 5% to even 50% of short-term travellers engaged in CSE during foreign trips. Read More

Urol Clin North Am 2015 Nov;42(4):507-18

Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 900, Chicago, IL 60611, USA. Electronic address:

Sexually transmitted infections (STIs) remain a significant burden on public health in the United States. Primary prevention counseling with early diagnosis and treatment remain the best methods to decrease the incidence of STIs. Through significant public heath interventions, the incidence of gonorrhea, Chlamydia, and trichomoniasis is decreasing; however, the incidence of primary and secondary syphilis is increasing. Read More

Scientifica (Cairo) 2015 8;2015:601624. Epub 2015 Sep 8.

Department of Urology, North Manchester General Hospital, Delaunay's Road, Manchester, UK.

Background. Tuberculosis of the penis (TBP) is rare. Aim. Read More