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Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Petrous apex cholesterol granulomas are believed to result from blockage of the normal aeration of the petrous air cells, resulting in a repetitive cycle of mucosal engorgement, hemorrhage, and granuloma formation.1 The lesion usually progressively expands causing compressive symptoms. The thick granulomatous wall envelopes various ages of breakdown products, including a cholesterol-containing fluid, which is typically hyperintense on T1 and T2 weighted magnetic resonance imaging. Read More

BJU Int 2021 Jun 10. Epub 2021 Jun 10.

Alder Hey Children's Hospital, Liverpool, United Kingdom.

Objectives: To determine: (i) feasibility for an RCT comparing circumcision to preputioplasty and intralesional triamcinolone (PIT) to treat Balanitis Xerotica Obliterans (BXO) and (ii) patient outcomes to inform future study design.

Patients And Methods: Approval was obtained from HRA/REC (16/NW/0364) and trial protocol registered (NCT02854995). Twenty boys (2-16 years) with BXO were randomized to either circumcision or PIT (online parallel group 1:1 allocation, non blinded). Read More

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

School of Medicine, University of Notre Dame, Fremantle, Western Australia, Australia.

We present a case of a 70-year-old Caucasian woman with multisystem granulomatous disease involving her lungs, bones and lymph nodes. The patient initially presented with cervical lymphadenopathy and subsequently developed progressive breathlessness. Imaging revealed extensive mediastinal, hilar and intra-abdominal lymphadenopathy as well as bilateral pulmonary parenchymal infiltrates. Read More

J Infect Dev Ctries 2021 May 31;15(5):736-741. Epub 2021 May 31.

Institute of Animal Health and Production, Federal Rural University of Amazonia, Belém, Brazil.

Introduction: Zoonotic tuberculosis is a disease of public health importance worldwide, especially in developing countries. The present study aimed to investigate the role played by Mycobacterium bovis and other mycobacteria as etiologic agents of bubaline tuberculosis (TB) in the Brazilian Amazon region.

Methodology: Granulomatous lesions suggestive of TB obtained from 109 buffaloes (n =109) during sanitary inspection at slaughter were subjected to histopathological evaluation, immunohistochemical (IHC) detection of Mycobacterium antigens, and to molecular tests (PCR) to detect hsp65, IS6110 and RD4 genes, which are specific to Mycobacterium spp. Read More

Medicine (Baltimore) 2021 May;100(19):e25860

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Kiyose City, Tokyo.

Rationale: Inhalation of toxic agents can induce eosinophilic pneumonia. However, only a few case reports demonstrate that exposure to materials can induce chronic eosinophilic pneumonia (CEP). Here, we describe a rare case of CEP with mild alveolar hemorrhage due to the inhalation of aerosols from face lotion. Read More

JAMA Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: Although granuloma annulare (GA) has been associated with several other conditions, these studies have been limited by single-center designs and small sample sizes.

Objective: To evaluate whether there is an association between GA and type 2 diabetes, hyperlipidemia, autoimmune conditions, and hematologic malignant neoplasms, using a large population-based cohort study.

Design, Setting, And Participants: This retrospective cohort study conducted between January 1, 2016, and June 30, 2019, used deidentified data from the US Optum Clinformatics Data Mart Database. Read More

JAMA Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: Although several single-center studies have estimated that granuloma annulare may account for approximately 0.1% to 0.4% of new patients presenting to dermatologists, large-scale population-based studies estimating the prevalence and incidence of granuloma annulare are lacking. Read More

Occup Med (Lond) 2021 Jun 9. Epub 2021 Jun 9.

Orthopedic and Trauma Surgery Department, Hospital de Terrassa, Barcelona, Spain.

Giant cell reparative granuloma (GCRG) is a rare, pseudotumoural intraosseous lesion, considered a reactive injury after repeated trauma. Reactive lesions and benign bone tumours may show aggressive clinical and radiographic findings. Differential diagnosis must be performed in order to offer suitable treatment to the patient. Read More

J Surg Case Rep 2021 Jun 4;2021(6):rjab199. Epub 2021 Jun 4.

Department of Breast Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

Granulomatous mastitis is a rare breast disease that is categorized as a benign tumor with chronic inflammation. Since the cause of the chronic inflammation is usually unknown, it is sometimes called idiopathic granulomatous mastitis (IGM). Although imaging modalities, such as ultrasound, magnetic resonance imaging and mammography can detect tumors, they are sometimes unable to differentiate between benign and malignant tumors. Read More

Pan Afr Med J 2021 8;38:245. Epub 2021 Mar 8.

Department of Radiology, Alexis Multispecialty Hospital, Nagpur, Maharashtra, India.

Pulmonary lesions on imaging are presumed to be metastatic lesions in patients with breast cancer. Here, we report an interesting case of a 63-year-old lady with breast carcinoma showing pulmonary lesions on imaging suggestive of pulmonary metastases. Detailed evaluation of pulmonary lesions confirmed the presence of co-existing pulmonary sarcoidosis. Read More

Urologe A 2021 Jun 8. Epub 2021 Jun 8.

Klinik für Urologie, Universitätsklinikum Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Deutschland.

We present the case of a 57-year-old man who developed an intraperitoneal bladder fistula with BCG-induced (bacillus Calmette-Guérin) abdominal granulomatosis after transurethral resection of a papillary non-muscle invasive bladder cancer and subsequent BCG-instillation therapy. The bladder fistula was eliminated surgically. The detection of Mycobacterium tuberculosis in the operative sample drawings as well as the histological detection of BCG-granuloma led to specific treatment and a report to the responsible health department. Read More

Indian J Tuberc 2021 Jul 4;68(3):416-419. Epub 2020 Nov 4.

Pulmonology, National Institute of Diseases of Chest and Hospital (NIDCH), Dhaka, Bangladesh.

Myocardial tuberculosis is an exceptionally rare form of extra-pulmonary TB. Few cases were reported world-wide. Here a young snake charmer who had skin tuberculosis 5 yrs back admitted into National institute of diseases of Chest and hospital (NIDCH), Dhaka with the complaints of cough, palpitation and breathlessness for 2 months. Read More

Indian J Tuberc 2021 Jul 9;68(3):389-395. Epub 2019 Aug 9.

Department of Obstetrics and Gynaecology, All India Institute of Medical Science, New Delhi-110029, India. Electronic address:

Aims: To demonstrate a new laparoscopic sign "Sharma's Parachute sign" in abdominopelvic tuberculosis in women with infertility.

Methods: A total of 104 women who were diagnosed to have abdominopelvic tuberculosis, on endometrial sampling or on laparoscopy were enrolled in this ongoing study on tuberculosis in infertility. A new laparoscopic "Sharma's parachute sign" was looked for in these cases on laparoscopy. Read More

Indian J Tuberc 2021 Jul 24;68(3):340-349. Epub 2020 Oct 24.

Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.

Background: Tuberculosis is a chronic infection caused by Mycobacterium tuberculosis (M.tb), which needs proper macrophage activation for control. It has been debated whether the co-infection with helminth will affect the immune response to mycobacterial infection. Read More

Biol Futur 2021 Mar 25;72(1):61-68. Epub 2021 Feb 25.

Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, USA.

Persistent irritants that are resistant to innate and cognate immunity induce granulomas. These macrophage-dominated lesions that partially isolate the healthy tissue from the irritant and the irritant induced inflammation. Particles, toxins, autoantigens and infectious agents can induce granulomas. Read More

Urol Case Rep 2021 Sep 23;38:101728. Epub 2021 May 23.

Department of Surgical, Oncological and Oral Sciences, Section of Urology, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.

Pearling is a practice of inserting small beads beneath the skin of the genitalia. Patients generally underwent this practice believing that this would have made their penis bigger and able to better satisfy their partners during intercourse. Pearling can cause complications. Read More

Case Rep Dent 2021 21;2021:5575896. Epub 2021 May 21.

Department of Oral and Maxillofacial Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Pyogenic granuloma (PG) refers to a common, acquired, benign, and vascular tumor that arises in tissues such as the skin and mucous membranes. However, it is extremely rare for PG to arise from an empty socket after tooth extraction. Herein, we describe a rare case of PG that arose from the empty extraction socket of the second molar adjacent to a dentigerous cyst of the left mandibular wisdom tooth in a 57-year-old man. Read More

Oxid Med Cell Longev 2021 14;2021:6652775. Epub 2021 May 14.

Research Institute for Experimental and Clinical Medicine, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, Russia.

The redox-sensitive signaling system Keap1/Nrf2/ARE is a premier protective mechanism against oxidative stress that plays a key role in the pathogenesis and development of various diseases, including tuberculous granulomatous inflammation. We have previously reported that novel water-soluble phenolic antioxidant TS-13 (sodium 3-(4'-methoxyphenyl)propyl thiosulfonate) induces Keap1/Nrf2/ARE and attenuates inflammation. The aim of this study is the examination of the effect of TS-13 on tuberculous granulomatous inflammation. Read More

J Oral Pathol Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells. It can involve single or multiple organs and systems, with bone and skin being the most commonly affected sites. Regarding skeletal manifestations, the jawbones are involved in about 20% to 30% of all cases. Read More

Dermatol Ther 2021 Jun 5. Epub 2021 Jun 5.

Department of Dermatology, Dr Ram Manohar Lohia Hospital and ABVIMS, New Delhi, India.

Actas Dermosifiliogr 2021 Jun 11;112(6):559-563. Epub 2021 Feb 11.

Departamento de Dermatología, Hospital Clínic de Barcelona, Universidad de Barcelona, Barcelona, Spain.

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):308-314

Servicio de Patología, Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú.

Epithelioid granuloma is a characteristic histological feature of Crohn's disease (CD), but their significance with respect to the severity and progression of the disease is still uncertain.

Objective: To evaluate the clinical characteristics of CD patients in relation to the presence or not of granulomas in histological findings.

Materials And Methods: An observational, descriptive, retrospective study in patients diagnosed with CD from January 2004 to December 2019 in the gastroenterology department of the Guillermo Almenara Irigoyen National Hospital, Lima-Peru. Read More

Ophthalmic Plast Reconstr Surg 2021 Jun 4. Epub 2021 Jun 4.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia Division of Sonic Healthcare Limited, Clinpath Pathology, Mile End, South Australia, Australia Flinders Eye Centre, Bedford Park, South Australia, Australia.

We present the case of a Caucasian woman with a histology-confirmed granuloma faciale of the tarsoconjunctival surface of the eyelid. A 66-year-old female patient presented with a 1-week history of painless left upper eyelid mass without history of allergy, trauma, or ocular surgery. There was an elevated well-demarcated flesh-colored lesion within the tarsus. Read More

Ann Saudi Med 2021 May-Jun;41(3):186-189. Epub 2021 Jun 1.

From the Department of Surgery Pietro Valdoni, Umberto I Policlinico, Roma, Italy.

At least 27 million men present with urogenital manifestations of genital filariasis (GF). Although there is a large burden of GF in residents in endemic regions, infection in short-term travellers and in non-endemic areas is rare. We report the case of a 75-year-old Italian man referred to our institution for a testicular discomfort. Read More

Korean Circ J 2021 May 10. Epub 2021 May 10.

Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.

The etiology and the progression of sarcoidosis remain unknown. However, cardiac sarcoidosis (CS) is significantly associated with a poor prognosis due to the associated congestive heart failure, arrhythmias (such as an advanced atrioventricular block), and ventricular tachyarrhythmia. Novel imaging modalities are now available to detect CS lesions secondary to active inflammation, granuloma formation, and fibrotic changes. Read More

Surg Neurol Int 2021 19;12:167. Epub 2021 Apr 19.

Department of Neurosurgery, Northeast National Medical Center, Monterrey, Mexico.

Background: has a tropism for the nervous system with a higher prevalence of infection in immunosuppressed patients; it remains a major cause of human immunodeficiency virus (HIV)-related mortality worldwide. Neurological compromise caused by this microorganism mainly debuts as a meningeal syndrome, spinal involvement has been reported in literature, neuropathological assessments have found Cryptococci in spinal roots and meninges, with perineuritic adhesions probably explaining compromise lower cranial nerves and even spinal nerve roots.

Case Description: 39-year-old male seronegative for HIV, with a surgical history of hydrocephalus treated with ventriculoperitoneal shut 1 year before, he presented with progressive weakness in the four extremities evolving to be disabling with bilateral accessory nerve palsy and loss of sensation below his neck. Read More

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S99-S108. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Post Graduate Institute of Dental Sciences, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana, India.

A 24-year-old male reported to the outpatient department with a complaint of swelling of the anterior lower jaw region for 9 months with history of traumatic injury and extraction of teeth from the same region, a month before the onset of swelling. Swelling was obvious extra- and intraorally which on examination presented as a soft to firm non-tender and non-fluctuant mass with an approximate size of 4 cm × 3 cm, extending from 34 to 43 region with obliteration of labial vestibule. Panoramic radiograph and cone-beam computed tomography showed a well-defined radiolucency in the mandibular anterior region crossing the midline with erosion of labial bony plates and root of 42 along with a tooth-like radiopaque mass within the lesion. Read More

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S42-S45. Epub 2021 Mar 19.

Department of Public Health Dentistry, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an ulcerative condition of the oral mucosa amid a chronic course and delayed healing. It is a reactive lesion that usually affects the tongue. TUGSE is a rare mucosal lesion to aid as an ulcer or an indurated submucosal mass and might cause diagnostic problems as it mimics a traumatic or neoplastic ulcer. Read More

Dermatol Ther 2021 Jun 3:e15021. Epub 2021 Jun 3.

Department of Dermatology, University of Trieste, Trieste, Italy.