Pediatrics 2018 Feb 3;141(2). Epub 2018 Jan 3.

Dermatology Department, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal; and.

Granuloma gluteale infantum is a rare nodular complication of irritant diaper dermatitis. The association of this condition with the widespread use of nondisposable cloth diapers has been increasingly recognized. We present the case of an 18-month-old girl with granuloma gluteale infantum. Read More

J Dermatol 2013 Dec 4;40(12):1038-41. Epub 2013 Dec 4.

Department of Dermatology, Nara Hospital, Kinki University School of Medicine, Nara, Japan.

An infant skin disease with clusters of nodules in the diaper contact area was reported as granuloma gluteale infantum. Recently, the number of elderly patients with this condition has increased, and it has been reported as diaper-area granuloma of the aged. These lesions are presumably caused by irritation from feces and urine. Read More

J Family Community Med 2010 May;17(2):107-9

Department of Dermatology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.

Granuloma Gluteale Infantum (GGI) is a rare condition of unclear etiology,[1] presenting as asymptomatic cherry red nodules in the diaper area appearing in the setting of primary irritant contact dermatitis.[2] A 50 day old infant with GGI is presented to emphasize that the condition may be easily missed, and that it may result from the misuse of fluorinated topical steroids used to treat a rash in the diaper area. This is the first case reported from Saudi Arabia. Read More

Cutis 2008 Jul;82(1):72-4

Baylor College of Medicine, Houston, TX, USA.

Jacquet erosive diaper dermatitis is typically described as a severe irritant dermatitis of the perianal region. However, Jacquet erosive diaper dermatitis, perianal pseudoverrucous papules and nodules, and granuloma gluteale infantum/ adultorum have been regarded as discrete entities or all part of the same clinical spectrum, representing the result of chronic, severe, irritant contact dermatitis. We present a case of Jacquet erosive diaper dermatitis and a discussion of the clinical spectrum of diseases to which it belongs. Read More

J Am Acad Dermatol 2006 Nov 1;55(5 Suppl):S74-80. Epub 2006 Sep 1.

Department of Dermatology, University of Utah, USA.

Granuloma gluteale infantum/adultorum, pseudoverrucous papules, and Jacquet's erosive diaper dermatitis are fairly uncommon manifestations of irritant contact dermatitis historically thought to be distinct clinical entities. Here we report two informative cases of an erosive papulonodular dermatosis in the genital and suprapubic area associated with topical benzocaine. We review granuloma gluteale infantum, pseudoverrucous papules and nodules, and Jacquet's erosive diaper dermatitis, and propose that these disorders may all be variants of genitocrural irritant dermatitis. Read More

J Cutan Med Surg 2002 May-Jun;6(3):221-5. Epub 2002 May 13.

Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Alberta, Canada.

Background: Granuloma gluteale infantum is a skin disorder of controversial etiology manifested clinically by oval reddish-purple granulomatous nodules on the gluteal surfaces and groin areas of infants. Similar granulomas are noted in adults and the elderly and are referred to as granuloma gluteale adultorum and diaper area granuloma of the aged, respectively. Occlusion from diapers, paper napkins, plastic pants, detergents, starch, powder, halogenated steroids, candidal infection, and urine and feces are postulated as possible etiologies. Read More

J Dermatol 2001 Apr;28(4):231-3

Department of Dermatology, Faculty for Clinical Research, Kumamoto National Hospital, 1-5 Ninomaru, Kumamoto 860-0008, Japan.

Two Japanese girls had small grouped papules on the buttocks without diaper dermatitis or bacterial or fungal infection. These granulomas spontaneously regressed over two weeks, even though oral antibiotics were administered. We discuss this variant of granuloma gluteale infantum of Tappeiner et al. Read More

Pediatr Dermatol 2000 Mar-Apr;17(2):141-3

Department of Dermatology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.

Granuloma gluteale infantum is a benign disorder with the clinical appearance of "granulomatous" nodules involving the diaper area. It is an uncommon disorder considered a complication of primary irritant diaper dermatitis. A 6-month-old boy with reddish-purple oval nodules located on the right inguinal fold and right buttock diagnosed as granuloma gluteale infantum is presented. Read More

Australas J Dermatol 1996 Feb;37(1):57-8

Westmead Hospital, Westmead, New South Wales, Australia.

Granuloma gluteale infantum is an uncommon disorder, the pathogenesis of which remains unclear. Occlusion is a common factor and irritant napkin dermatitis is a frequent association. A six month old female infant with mild napkin dermatitis treated only with a dusting powder is presented. Read More

J Pediatr 1994 Dec;125(6 Pt 1):914-6

Department of Dermatology, Hospital General Vall D'Hebron, Barcelona, Spain.

We report two patients with Hirschsprung disease in whom severe diarrhea and a distinctive diaper dermatitis developed after delayed ileoanal anastomosis. The perianal papulonodular lesions cleared in months or years without specific treatment after resolution of the diarrhea. These perianal pseudoverrucous papules and nodules represent a peculiar form of primary irritant diaper dermatitis, distinct from Jacquet erosive diaper dermatitis and granuloma gluteale infantum. Read More

J Dermatol 1991 Nov;18(11):671-5

Department of Dermatology, Tenri Hospital, Nara, Japan.

Two cases of diaper area granuloma are reported. Patient 1, a 34-year-old man, had multiple reddish-purple nodules over the diaper area of the right part of the genitocrural region. Candida albicans was not detected from the lesion. Read More

Pediatr Dermatol 1990 Sep;7(3):196-8

Division of Dermatology, University of Texas Health Science Center, San Antonio 78284-7876.

Granuloma gluteale infantum, a benign granulomatous eruption involving the gluteal region, histologically shows a nonspecific dermal inflammatory infiltrate composed of neutrophils, lymphocytes, histiocytes, plasma cells, and eosinophils. It is important to recognize this condition, as it may clinically simulate a neoplastic process. It arises as a complication of primary irritant diaper dermatitis, however, and typically resolves without treatment. Read More

Arch Dermatol 1989 Dec;125(12):1703-4, 1706-7

American University of Beirut (Lebanon) Medical Center.

Arch Emerg Med 1988 Jun;5(2):113-5

Accident and Emergency Department, Royal Liverpool Children's Hospital (Alder Hey), England.

Pediatr Med Chir 1985 Jan-Feb;7(1):137-9

A 5 months old infant having "granuloma gluteale infantum" (G.G.I. Read More

Cutis 1983 May;31(5):489, 493

Ann Pediatr (Paris) 1982 Jan;29(1):53-9

Cutis 1981 Dec;28(6):644, 648

An infant had a persistent ulcerative nodular diaper dermatitis with negative laboratory findings for pathogens. With bland therapy and avoidance of powdering, the lesions cleared. This reaction was considered, without proof, to be granuloma gluteale infantum. Read More

Clin Exp Dermatol 1981 Jan;6(1):23-9

Acta Derm Venereol Suppl (Stockh) 1981 ;95:40-2

Seborrhoeic dermatitis is described clinically and histologically with emphasis upon the vague definition of the disease. The relationship between pityriasis asteatosa and psoriasis is discussed. Napkin dermatitis is subdivided into infantile seborrhoeic dermatitis and true napkin dermatitis. Read More

Ann Dermatol Venereol 1980 Jul;107(7):631-4

Intracytoplasmic structures resembling rickettsia-like bodies are observed in the dermal macrophages of a case of granuloma gluteale infantum. The cells which contained these bodies show severe necrotic changes. No yeast and nor crystalline structures were observed in the dermal infiltrate. Read More

Arch Dermatol 1978 Mar;114(3):382-3

Nine women, aged 77 to 89 years, suffered from diaper dermatitis, and many granulomas were seen in the genital or gluteal region restricted to the lesion of dermatitis. Because these granulomas resembled granuloma gluteale infantum of Tappeiner and Pfleger, we propose to call this condition diaper area granuloma of the aged. Read More

Orv Hetil 1977 Nov;118(48):2905-7

Australas J Dermatol 1977 Apr;18(1):20-4

Arch Dermatol 1976 Apr;112(4):564

Med Cutan Ibero Lat Am 1976 ;4(5):359-64

Bibliographic review of all the published cases of granuloma gluteale infantum and study of the second observation in Argentina. In this case there was a previous Leiner's erythrodermia treated with fluorinatec corticoid creams. The typical lesions appeared suddenly. Read More

Hautarzt 1971 Sep;22(9):383-8