Search Our Scientific Publications & Authors

J Eur Acad Dermatol Venereol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Venereology, Leprology, Post Graduate Institute of Medical Education and Research, Sector 12Chandigarh, India.

Background: Leprosy is a chronic granulomatous infection with varied clinical presentations. In this study, we aimed to describe the dermatoscopic features of the entire spectrum of leprosy and to correlate with clinical and histopathological findings.

Methodology: This was a prospective observational study of treatment naïve leprosy patients over a period of 1 year. Read More

Front Microbiol 2019 3;10:693. Epub 2019 Apr 3.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Infections caused by complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated and associated with relatively poor outcome. Identification of new animal models that demonstrate a similar pulmonary pathology as humans infected with MAC has the potential to significantly advance our understanding of nontuberculosis mycobacteria (NTM) pathogenesis as well as provide a tractable model for screening candidate compounds for therapy. Read More

PLoS Pathog 2019 Apr 18;15(4):e1007724. Epub 2019 Apr 18.

Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, The Netherlands.

Type 2 diabetes mellitus (DM) is a major risk factor for developing tuberculosis (TB). TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence. At present, the causal underlying mechanisms linking DM and TB remain unclear. Read More

PLoS One 2019 18;14(4):e0215621. Epub 2019 Apr 18.

Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Bologna, Italy.

Squamous cell carcinoma is the most common malignant oral tumor in cats. The late presentation is one of the factors contributing to the detrimental prognosis of this disease. The immunohistochemical expression of the p53 tumor suppressor protein has been reported in 24% to 65% of feline oral squamous cell carcinomas, but no study has systematically evaluated in this tumor the presence of p53 encoding gene (TP53) mutations. Read More

J Craniofac Surg 2019 Apr 12. Epub 2019 Apr 12.

MGM Dental College and Hospital, Navi Mumbai, India.

Flap necrosis is a very common complication encountered after cleft palate repair, especially in uni-pedicled flaps. Many causes have been attributed to this complication but very limited data is available in the literature on dental infection as the cause of flap necrosis. This report of a case describes loss of flap caused due to a periapical granuloma of dental origin impinging on the pedicle causing suspected thrombosis of the pedicle resulting in flap necrosis. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e128-e132

A 71-year-old white male presented with unilateral trace vitreous cell and hypopigmented choroidal lesions, corresponding to hyporeflective areas on optical coherence tomography (OCT). The lesions grew slowly during a period of 2.5 years, but the patient remained asymptomatic. Read More

Clin Ter 2019 Mar-Apr;170(2):e86-e92

Registered Nurse, Clinical Specialist in Wound Care, Clinical Specialist in Ostomy Care, Independent Tissue Viability Consultant, Rome, Italy.

Background: Peristomal granulomatosis is a chronic inflammatory disease of uncertain aetiology, and a high recurrence rate. It frequently occurs in patients with enterostomy and urostomy. The most frequent type affects the mucocutaneous junction, causing bleeding and painful nodular lesions, which complicate management of the ostomy pouching system. Read More

J Am Acad Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Consultant Dermatologist, Kaya Skin Clinic, New Delhi, India.

Pathol Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Tokai University School of Medicine, Isehara, Japan.

We aimed to propose a biosafety algorithmfor the protection of pathology staff during intraoperative examinations of pulmonary lesions when working with cytological imprints and/or frozen sections for the intraoperative diagnosis of pulmonary lesions. We examined 148 pulmonary surgical tissues obtained intraoperatively for imprint cytology (IC) and for frozen sectioning and compared the diagnoses against the final pathological diagnoses. We analyzed concordance and non-concordance rates and then used the data to produce a biosafety algorithm. Read More

Ocul Immunol Inflamm 2019 Apr 15:1-4. Epub 2019 Apr 15.

a Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Background: Ocular tuberculosis can have protean manifestations. Anti-tubercular therapy (ATT) and oral steroids are employed in the management of this condition. There is evidence in the literature which has highlighted the use of intravitreal anti-vascular endothelial growth factor drugs as an adjunct to systemic therapy. Read More

Indian J Nephrol 2019 Mar-Apr;29(2):132-134

Department of Nephrology, PGIMER, Chandigarh, India.

Massive rectal bleeding is an uncommon presentation of ileal tuberculosis (TB). We report an uncommon cause of anemia in a post-renal transplant patient due to massive lower gastrointestinal (LGI) bleed. The index case had a normal upper and LGI endoscopy, but the technetium labeled red blood cell scan showed active bleeding from terminal ileum and caecum. Read More

Oper Neurosurg (Hagerstown) 2019 May;16(5):557-570

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: The endoscopic endonasal approach (EEA) was recently added to the neurosurgical armamentarium as an alternative approach to the petrous apex (PA) region. However, the maximal extension, anatomical landmarks, and indications of this procedure remain to be established.

Objective: To investigate the limitations and suggest a classification of PA lesions for endoscopic petrosectomy. Read More

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Granuloma annulare (GA) is a fairly common inflammatory skin condition with a range of clinical subtypes. We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. Read More

J Stomatol Oral Maxillofac Surg 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Epulis is a benign tumor, rarely involves aggressive alveolar bone resorption. This study reported a rare case of a rapid growth of pregnancy epulis with extensive alveolar bone destruction and the management of this case. A 24-year old pregnant woman at 35 weeks and 1 day of gestation presented a large asymptomatic nodular mass with severe teeth loosening at the anterior mandibular region for 4 weeks. Read More

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Dermatology, Catholic University - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

A 66-year-old psoriatic patient was examined for the occurrence of annular lesions with a dermatomeric distribution on the trunk since four weeks. The patient claimed that the lesions appeared at the site of a previous Herpes Zoster virus (HZV) infection, which had been treated with intravenous acyclovir three months earlier. At the time of the annular eruption, the patient was under treatment with apremilast (30 mg twice daily) for moderate-to-severe psoriasis, and systemic mycophenolate mofetil (1,250 gr daily), methylprednisolone (4 mg daily) and tacrolimus (1 mg daily) due to liver transplantation four years earlier for a cryptogenic liver cirrhosis. Read More

Hernia 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10000, Zagreb, Croatia.

Purpose: The study aimed to evaluate the histologic properties and infection resistance of three different mesh materials in a rat model.

Methods: Each mesh, in both infectious (n = 96) and non-infectious groups (n = 270), was positioned both in sublay (preperitoneally) and onlay (subcutaneously) locations. Properties of the biological (Surgisis; Cook Surgical), composite, partially resorbing (Vypro II mesh; Ethicon) and non-resorbing (TiMesh; GFE Medizintechnik GmbH) mesh were evaluated and compared. Read More

J Bone Oncol 2019 Jun 6;16:100229. Epub 2019 Mar 6.

Department of Pediatric Orthopaedic Surgery, Children's Hospital Hamburg-Altona, Hamburg, Germany.

Backround: This retrospective study aimed to determine the frequency of bone tumours of the clavicle and their histopathological, anatomical and epidemiological characteristics in a large case series.

Methods: The records of 327 lesions of the clavicle collected from 1976 to 2018 in our bone tumour registry and institute of pathology were reviewed. Following data were evaluated: age, gender, side, radiological assessment, tumour location within the clavicle, and histopathological findings. Read More

Open Access Maced J Med Sci 2019 Mar 27;7(6):973-977. Epub 2019 Mar 27.

Section of Dermatology, University of Naples Federico II, Naples, Italy via Sergio Pansini 5, 80131 Naples, Italy.

Background: Tyrosine kinase inhibitors (TKIs) have been introduced for the treatment of lung cancer, improving progression-free survival, objective response rate, and quality of life. However, TKIs can lead to cutaneous toxicities, including papulopustular rash, xerosis, paronychia with/without pyogenic granulomas, scalp disorders, facial hair and/or eyelash growth.

Aim: In this study, we describe retrospectively all cases of mucocutaneous side effects in patients with lung cancer under TKIs referring to our outpatient for the skin care of oncological patients. Read More

J Thorac Dis 2019 Feb;11(2):557-563

Department of Thoracic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Background: The detection rate of ground-glass opacity (GGO) in young patients has increased year by year with the increasingly widespread use of high-resolution computed tomography (HRCT) and the increased resolution of HRCT imaging. However, no scholars have reported the clinical characteristics and prognosis of GGO in young patients systematically. The purpose of this study is to investigate the clinical characteristics and prognosis presenting as GGO in young patients. Read More

Ann Med Surg (Lond) 2019 May 21;41:1-5. Epub 2019 Mar 21.

Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Introduction: Bacterial biofilms can be calcified. Granulomas or cystic lesions are the most commonly found entities in endodontics. Surprisingly, this case report presents a rare radiopaque image, in a fan shape, of a calculus-like deposit in the periapical region of the maxillary left central incisor. Read More

J Dtsch Dermatol Ges 2019 04;17(4):445-447

Hautklinik des Universitätsklinikums Münster, Westfälische Wilhelms-Universität Münster, Münster, Deutschland.

J Paediatr Child Health 2019 Apr;55(4):486-487

Division of Oral and Maxillofacial Surgery, Dublin Dental Univeristy Hospital Trinity College Dublin, Dublin, Republic of Ireland.

Case Rep Med 2019 6;2019:4341098. Epub 2019 Mar 6.

Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA.

Sarcoidosis is a multisystem granulomatous disease that most commonly affects the lungs but can affect other organs including the heart due to granuloma infiltration. Atrioventricular block is a common manifestation of cardiac sarcoidosis which can progress to sudden cardiac death. We report a case of cardiac sarcoidosis presenting as complete heart block, progressing to diastolic and systolic dysfunction without extracardiac manifestations early in the disease. Read More

Med Clin North Am 2019 May 21;103(3):527-534. Epub 2019 Feb 21.

Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Sarcoidosis is a multisystemic granulomatous disease that affects individuals worldwide. The lungs are most commonly involved but any organ can be involved. It has variable manifestations and clinical course. Read More

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840736

2 Hand Microsurgery Orthopaedics and Traumatology (EMOT) Hospital, Izmir, Turkey.

Purpose:: Deep palmar tumors of the hand are very rare, and reported cases are usually benign. The most important issue is frequent anatomical variations with challenging surgical exposure and excision of these lesions. Some case reports or a small series of patients have been reported in the literature. Read More

Microb Pathog 2019 Apr 3;131:158-163. Epub 2019 Apr 3.

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, USA. Electronic address:

Mycobacterium tuberculosis (Mtb) has the extraordinary ability to persist for decades within granulomas in the human host. These histopathological structures involved in both protection and pathogenesis, are subject to various influences from the host systemically and through micro-niche environments. Despite the fact that vitamin D (VD) has a key role in macrophage activation and mycobacterial clearance in the early stages of Mtb infection, the overall role of VD in granuloma maintenance or functionality has been scarcely studied. Read More

Ophthalmology 2019 Apr 3. Epub 2019 Apr 3.

Vanderbilt Eye Institute, Vanderbilt University, Nashville, Tennessee.

Purpose: To determine the efficacy and complication rates of monocanalicular stents in the setting of canalicular lacerations.

Methods: A literature search was performed in May 2018 in the PubMed database to identify all English-language reports of monocanalicular stenting to address canalicular lacerations. Studies that did not include at least 10 patients with at least 3 months of follow-up evaluation after surgery were excluded. Read More

Trans R Soc Trop Med Hyg 2019 Apr 6. Epub 2019 Apr 6.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, UP, India 226014.

Background: Patients with neurocysticercosis (NCC) may have an increased frequency of migraine. We studied the characteristics of migraine attacks in patients with calcified NCC on brain imaging.

Methods: Of 350 migraine patients who visited our outpatient department from January 2016 through June 2018, 166 had undergone brain imaging. Read More

Clin Liver Dis 2019 May 2;23(2):331-343. Epub 2019 Mar 2.

Division of Gastroenterology, University of South Alabama College of Medicine, UCOM 6000, 75 University Boulevard South, Mobile, AL 36688, USA. Electronic address:

Hepatic granulomas are a common finding in systemic sarcoidosis, but most patients remain asymptomatic. Elevated alkaline phosphatase is the most common sign of hepatic sarcoidosis (HS). Lacking a specific diagnostic test, the diagnosis of HS is one of exclusion. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15039

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Amyloidosis secondary to intrapulmonary Castleman disease (CD) is a rare benign disease diagnosed by histopathology. It seems to be associated with chronic inflammation, and large amounts of IL-6 produced in the germinal center of CD may enhance the production of precursor of amyloid.

Patient Concerns: We reported a case of an 18-year-old woman presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia. Read More

Eye (Lond) 2019 Apr 3. Epub 2019 Apr 3.

Mansoura Ophthalmic center, Mansoura University, Mansoura, Egypt.

Purpose: The purpose of this study is to evaluate the efficacy of systemic antiparasitic medications alone or in combination with surgical aspiration in management of presumed trematode-induced anterior uveitis in children.

Patients And Methods: Prospective case series. Children who presented with anterior chamber (AC) granuloma were included in the study. Read More

Breast J 2019 Apr 3. Epub 2019 Apr 3.

Pathology Department, Instituto Português de Oncologia do Porto, Porto, Portugal.

Evid Based Complement Alternat Med 2019 3;2019:8497980. Epub 2019 Mar 3.

Wonkwang University, College of Pharmacy, Department of Oriental Pharmacy & Wonkwang Oriental Medicines Research Institute, Iksan, Jeonbuk, Republic of Korea.

Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Read More

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

J Leukoc Biol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA.

Macrophages are the primary host cells for Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), during its intracellular survival in humans. The pathogen has a remarkable capacity to survive within the hostile environment of macrophages. However, primary infection does not result in active TB disease in most individuals. Read More

Int J Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, GMERS Medical College & Hospital, Sola, Ahmedabad, India.

Turkiye Parazitol Derg 2019 Mar;43(1):21-25

Adıyaman University Faculty of Medicine, Department of Pediatric Surgery, Adıyaman, Turkey

Objective: To evaluate the histopathological findings in appendectomy materials with infection.

Methods: Appendectomy materials with infection of 24 cases were evaluated for the presence of acute inflammation, congestion, hemorrhage, perforation, lymphoid hyperplasia (LH), necrosis, granuloma, fecalith, obliteration, hyalinization, eosinophilic infiltration and mucosal architectural distortion.

Results: The frequency of among 3222 appendectomies that were scanned for the study was 0. Read More

J Dent (Shiraz) 2019 Mar;20(1):10-15

Dept. of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.

Statement Of The Problem: There are some differences between clinical features of central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic features. The possible role of angiogenesis in this issue is still a matter of debate.

Purpose: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34. Read More

Saudi J Ophthalmol 2019 Jan-Mar;33(1):109-111. Epub 2018 Jul 25.

Pediatric Ophthalmology and Strabismus, Ophthalmology Department, King Abdul-Aziz University Hospital, King Saud University, Saudi Arabia.

We present a rare case of infected pyogenic conjunctival granuloma mimicking a conjunctival abscess as complication of strabismus surgery in a Saudi girl with exotropia. Despite administration of local antibiotics following strabismus surgery, a patient presented with localised redness and discharge after three weeks. The patient was afebrile with no signs of pre-septal or orbital cellulitis. Read More

J Infect Dis 2019 Mar 31. Epub 2019 Mar 31.

Texas Biomedical Research Institute, San Antonio, Texas.

Despite intensive research efforts, several fundamental disease processes for tuberculosis (TB) remain poorly understood. A central enigma is that host immunity is necessary to control disease yet promotes transmission by causing lung immunopathology. Our inability to distinguish these processes makes it challenging to design rational novel interventions. Read More

Vet Clin Pathol 2019 Mar;48(1):67-70

Department of Pathology, University of Georgia, Athens, Georgia.

A 4-year-old, spayed female French Bulldog was presented for respiratory distress and suspected aspiration pneumonia after oral administration of activated charcoal for possible ingestion of a suspected toxic dose of trazodone. The patient had a moderate volume of pleural effusion, which contained free and intracellular black particulate matter consistent with charcoal. Due to presumed charcoal aspiration with subsequent lung rupture, the right middle and right caudal lung lobes were surgically removed. Read More

Sci Rep 2019 Mar 28;9(1):5297. Epub 2019 Mar 28.

Department of Pathology and Immunology, Centre Medical Universitaire (CMU), Faculty of Medicine, University of Geneva, Geneva, 1211, Switzerland.

TNF plays a critical role in mononuclear cell recruitment during acute Bacillus Calmette-Guérin (BCG) infection leading to an effective immune response with granuloma formation, but may also cause tissue injury mediated by TNFR1 or TNFR2. Here we investigated the role of myeloid and T cell specific TNFR1 and R2 expression, and show that absence of TNFR1 in myeloid cells attenuated liver granuloma formation and liver injury in response to acute BCG infection, while TNFR2 expressed in myeloid cells contributed only to liver injury. TNFR1 was the main receptor controlling cytokine production by liver mononuclear cells after antigenic specific response, modified CD4/CD8 ratio and NK, NKT and regulatory T cell recruitment. Read More

BMC Ophthalmol 2019 Mar 29;19(1):83. Epub 2019 Mar 29.

Department of Ophthalmology & Visual Science Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-Ku, Tokyo, 113-8519, Japan.

Background: To report 2 cases of bilateral granulomatous panuveitis accompanied by chronic active Epstein-Barr virus infection (CAEBV).

Case Presentation: Case 1 was a 38-year-old man who had a history of bilateral mild panuveitis who was diagnosed with CAEBV. Fifteen months later, a severe bilateral granulomatous panuveitis developed. Read More

Ophthalmic Plast Reconstr Surg 2019 Mar 26. Epub 2019 Mar 26.

Department of Ophthalmology, UT Southwestern Medical Center.

Foreign-body granuloma formation following filler injections is most commonly seen with permanent fillers; these reactions can occur years following the injections and often require either an intralesional steroid injection or surgical excision. The authors present a case of a 75-year-old woman with a history of systemic sarcoidosis previously treated with numerous immunosuppressive medications who was examined for bilateral infraorbital nodules and swelling that were unresponsive to treatment. She underwent a bilateral anterior orbitotomy through a transconjunctival approach with mass excision. Read More

Eur J Immunol 2019 Mar 28. Epub 2019 Mar 28.

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Liège, Belgium.

Alternatively-activated Mφs (AAMφ) accumulate in hepatic granulomas during schistosomiasis and have been suggested to originate in the bone marrow. What is less understood is how these Mφ responses are regulated after S. mansoni infection. Read More

Pan Afr Med J 2018;31:11. Epub 2018 Sep 4.

Department of Plastic Surgery, Mohammed V Military Training Hospital, Rabat, Morocco.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Japan.

A 43-year-old man with malignant lymphoma who had been treated with the C-MOPP regimen was admitted to our hospital with skin eruption. He was diagnosed to have varicella, and treatment with acyclovir and immune globulin was started. Chest computed tomography revealed multiple nodules in the both lung fields. Read More