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    249 results match your criteria Granuloma Faciale

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    [Extra-facial Lever granuloma on a herpes zoster scar: Wolf's isotopic response].
    Ann Dermatol Venereol 2018 Apr 16. Epub 2018 Apr 16.
    Service de dermatologie, CHR Metz-Thionville, 1, allée du Château, 57245 Ars-Laquenexy, France.
    Background: Granuloma faciale (GF), or facial granuloma of Lever, is an uncommon dermatosis occurring classically on the face. We report a case of a GF on zoster scars located on the trunk, which is a highly particular isotopic response.

    Patients And Methods: A 60-year-old man with a sole history of left lumbar zoster presented with a skin lesion present for two months. Read More

    Cholesterol granuloma of the maxilla.
    Morphologie 2018 Mar 13;102(336):41-43. Epub 2018 Feb 13.
    Service de chirurgie maxillo-faciale et stomatologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex, France; Groupe études remodelage osseux et biomatériaux (GEROM) - LHEA, IRIS-Institut de biologie en santé (IBS), université d'Angers, CHU d'Angers, 49933 Angers cedex, France. Electronic address:
    Intra-osseous cholesterol granuloma (CG) is a rare and benign lesion. Very few cases of CG of the jaws have been described in the literature. CG of the jaws seems to be due to the accumulation of cholesterol of hematogenous origin in odontogenic cysts. Read More

    [Humoral immune diseases: Cutaneous vasculitis and auto-immune bullous dermatoses].
    Ann Pathol 2018 Feb 27;38(1):31-42. Epub 2017 Dec 27.
    Département de pathologie, service d'anatomie et de cytologie pathologiques, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    Humoral immunity is the cause of multiple diseases related to antibodies (IgA, IgG, IgM) produced by the patient. Two groups of diseases are identified. The first group is related to circulating antigen-antibody complexes. Read More

    Granuloma Faciale Treatment: A Systematic Review.
    Acta Derm Venereol 2018 Jan;98(1):14-18
    Department of Dermatology and Allergology, University Hospital Jena, Erfurter Strasse 35, DE-07743 Jena, Germany.
    Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. Read More

    Evaluating the clinical and demographic features of extrafacial granuloma faciale.
    Cutis 2017 Jul;100(1):E18-E22
    Department of Dermatology and the Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    Granuloma faciale (GF) is an uncommon cutaneous disease of uncertain etiology that predominantly affects the face. Extrafacial lesions are rare. The purpose of this study was to describe the clinical and demographic features of a series of patients with extrafacial manifestations of GF who were diagnosed and treated at a single center over more than 5 decades. Read More

    Extrafacial Granuloma Faciale: A Case Report and Brief Review.
    Case Rep Dermatol 2017 May-Aug;9(2):79-85. Epub 2017 Jul 13.
    Department of Dermatology, Mater Misericordiae Hospital, Brisbane, Queensland, Australia.
    Granuloma faciale (GF) is a rare, inflammatory, cutaneous disorder of unknown aetiology. It presents clinically as one or several well-circumscribed violaceous papules, plaques, and nodules almost exclusively confined to the facial region. Rarely, extrafacial lesions can occur, most often on sun-exposed sites. Read More

    [Common benign lesions of the vocal fold : diagnostic criteria and management].
    Rev Med Suisse 2016 Oct;12(533):1661-1664
    Unité de phoniatrie et de logopédie, Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHUV, 1011 Lausanne.
    The vocal cord or vocal fold is a remarkable structure, capable to support significant physical constraints. When the voice malmenage becomes chronic, it may appear an organic alteration causing nodules, polyps or Reinke edema even a lesion of the posterior glottis, the granuloma. These lesions are benign but lead to dysphonia that can be invalidating. Read More

    Complete Clearance of Resistant Granuloma Faciale With Pulsed Dye Laser After Pre-treatment With Mometasone and Tacrolimus.
    J Lasers Med Sci 2017 28;8(2):95-97. Epub 2017 Mar 28.
    Consultant Dermatologist and Senior Lecturer in Dermatology, Sir Paul Boffa Hospital, Harper Lane, Floriana FLR1940, Malta.
    Granuloma faciale is an uncommon inflammatory dermatosis which usually affects the face and is often resistant to treatment. A 39-year-old English lady with Fitzpatrick skin phototype II presented with typical lesions of granuloma faciale, confirmed on biopsy, on her cheeks and nose. Treatment with ScleroPlus pulsed dye laser (Candela Corporation, Wayland, Mass) produced no visible improvement. Read More

    [Granulomatous periocular eruption].
    Ann Dermatol Venereol 2017 Jun - Jul;144(6-7):430-433. Epub 2017 Apr 12.
    Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
    Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

    Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

    Granuloma faciale: clinical, morphological and immunohistochemical aspects in a series of 10 patients.
    An Bras Dermatol 2016 Nov-Dec;91(6):803-807
    Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - Botucatu (SP), Brazil.
    Granuloma faciale is a chronic, benign, cutaneous vasculitis with well-established clinical and morphological patterns, but with an unknown etiology. This study describes clinical and pathologic aspects of patients diagnosed with granuloma faciale. The authors analyzed demographic, clinical, morphological and immunohistochemical data from patients with a final diagnosis of granuloma faciale, confirmed between 1998 and 2012. Read More

    Disorders characterized by predominant or exclusive dermal inflammation.
    Semin Diagn Pathol 2017 May 14;34(3):273-284. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020 University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, USA. Electronic address:
    Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Read More

    Kimura's disease in a 50-year-old Tunisian man.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Apr 28;134(2):127-129. Epub 2016 Dec 28.
    Service d'anatomopathologie, hôpital d'instruction des armées Bégin, 94160 Saint-Mandé, France.
    Introduction: Kimura's disease is an uncommon disease of unknown aetiology affecting men in their thirties from Southeast Asia. The authors report a case of Kimura's disease in a 50-year-old Tunisian man that was diagnosed after surgery.

    Case Report: This patient had two 2-cm diameter chronic nodular lesions over the right mandible with no local inflammation and no other clinical findings of systemic disease. Read More

    Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum.
    Am J Dermatopathol 2017 Jun;39(6):479-484
    *Department of Pathology, Albany Medical College, Albany, NY; and †Departamento de Dermatología, Area de Dermatopatología, Hospital Luis Vernaza, Guayaquil, Ecuador.
    One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV. Read More

    Nasal NK/T-cell lymphoma: A tragic case.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Apr 24;134(2):121-122. Epub 2016 Oct 24.
    Service d'ORL et de Chirurgie Cervico-faciale, Hôpital 20-Août-1953, Casablanca, Morocco.
    Introduction: Nasal NK/T-cell lymphoma is a rare clinicopathological entity, formerly called midline lethal granuloma. Following progress in histology and the routine use of immunohistochemistry, nasal NK/T-cell lymphoma was recognized as a distinct entity by WHO in 2001.

    Case Report: The authors report the case of a 22-year-old, insulin-dependent diabetic woman, who presented with mid-facial inflammatory swelling following facial trauma, initially diagnosed and treated as cellulitis of the face. Read More

    [Differential diagnosis of basal cell carcinoma of the face: Dermatologist advice may avoid surgery].
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Nov 14;117(5):335-339. Epub 2016 Jul 14.
    Aix Marseille université, 13916 Marseille, France; Service de dermatologie, hôpital Nord, AP-HM, 13915 Marseille cedex 20, France.
    Introduction: Basal cell carcinoma (BCC) is the most common skin cancer in France. It is commonly diagnosed in front of a papule or nodule of the face. The surgeon should be able to question the diagnosis of BCC when nodular lesions are untypical, keeping in mind that some differential diagnoses require only medical treatment. Read More

    Approach to cutaneous vasculitides with special emphasis on small vessel vasculitis: histopathology and direct immunofluorescence.
    Curr Opin Rheumatol 2017 Jan;29(1):39-44
    Department of Pathology, Acıbadem University, Istanbul, Turkey.
    Purpose Of Review: The present review will focus on recent publications in cutaneous vasculitides.

    Recent Findings: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk. Read More

    Granuloma faciale treatment with tacrolimus.
    Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.
    Hospital Universitario Doctor Peset, Spain.
    We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region. A biopsy established the diagnosis of granuloma faciale. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism.
    Hum Pathol 2016 12 3;58:62-71. Epub 2016 Aug 3.
    INSERM, UMRS 1138, Centre de Recherche de Cordeliers, Molecular Oral Pathology, 75006 Paris, France; Université Paris Descartes, 75006 Paris, France; APHP, Necker Enfants Malades, Service de Chirurgie Maxillo-Faciale et Plastique, 75015 Paris, France; APHP, CRMR des Malformations Rares de la Face et de la Cavité Buccale, 75015 Paris, France.
    Cherubism is a rare genetic disease characterized by bilateral giant cell reparative granuloma of the jaws consisting of a fibrotic stroma with giant multinucleated cells (GMCs) and osteoclastic features. Cherubism severity is highly variable, and recurrence after surgery is the most important risk. Currently, there are no prognostic indicators. Read More

    Granuloma faciale successfully treated with ingenol mebutate.
    Dermatol Ther 2016 Sep 30;29(5):325-329. Epub 2016 Jun 30.
    Department of Clinical and Molecular Sciences, Dermatological Unit and.
    Granuloma faciale (GF) is a rare chronic inflammatory dermatosis of unknown etiology, characterized by leukocitoclastic vasculitis usually occurring on the face. We report a case of 60-years-old man with 3 year history of multiple actinic keratoses (AK) and persistent asymptomatic erythematous papules and plaques located over his left temporal region and the cheek: histopathology was consistent with GF. Herein we describe the successful treatment of the lesion with ingenol mebutate 0. Read More

    Granuloma faciale: An unusual diascopic finding.
    Indian Dermatol Online J 2016 May-Jun;7(3):174-6
    Department of Skin and STD, Dr. BR Ambedkar Medical College, Bangalore, Karnataka, India.
    Granuloma faciale (GF) is a benign, chronic inflammatory disorder, characterized by reddish brown plaques with prominent follicular orificesand telangeictasia, usually occurring over the face. The condition often presents a problem in differential diagnosis. Herein we describe a case of GF with an unusual diascopic finding of an apple jelly appearance on diascopy. Read More

    A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis.
    Ophthal Plast Reconstr Surg 2017 Mar/Apr;33(2):e47-e49
    Emory University School of Medicine, Atlanta, Georgia, U.S.A.
    Granuloma faciale is an eosinophilic dermatosis that typically presents as red-brown facial plaques of middle-aged white men, while eosinophilic angiocentric fibrosis is a histologically similar fibrotic condition affecting the respiratory mucosa. Both are very uncommon conditions and pose a therapeutic challenge. While a handful of reports have reported concurrent presentation, the authors present the first case of eyelid granuloma faciale with eosinophlilic angiocentric fibrosis. Read More

    "Drug-resistant granuloma faciale": treatment with carbon dioxide-GaAs laser.
    Dermatol Ther 2016 Sep 6;29(5):317-319. Epub 2016 Jun 6.
    ASL Viterbo, UOSD Dermatology, C.O.B. Belcolle, Italy.
    Granuloma faciale (GF), also known as "eosinophilic granuloma," is a rare benign leukocytoclastic vasculitis which most commonly occurs on the face of middle-aged Caucasian males. Clinically, GF appears as single or multiple, slowly growing, reddish-brown papules, nodules or plaques which may be cosmetically unpleasant. Its pathogenesis is unknown and GF is notoriously resistant to treatments. Read More

    Granuloma Faciale and Erythema Elevatum Diutinum in Relation to Immunoglobulin G4-Related Disease: An Appraisal of 32 Cases.
    Am J Clin Pathol 2016 Mar 2;145(3):401-6. Epub 2016 Mar 2.
    Departments of Dermatology, Pathology and Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, MN.
    Objectives: To elucidate whether granuloma faciale (GF) and erythema elevatum diutinum (EED), two inflammatory skin dermatoses, meet the consensus histopathologic diagnostic criteria for immunoglobulin G4-related disease (IgG4-RD).

    Methods: With institutional review board approval, we assessed the clinical, microscopic, and immunophenotypic features of skin specimens of patients with GF and EED. We compared these findings with previously published consensus diagnostic criteria for IgG4-RD. Read More

    [NK/T-cell Lymphoma of nasal-type: A rare affection with a poor prognosis].
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Jun 10;117(3):167-9. Epub 2016 Mar 10.
    Laboratoire d'anatomie et de cytologie pathologiques, hôpital Aristide le Dantec, Dakar, Sénégal.
    Introduction: NK/T cell lymphoma of nasal-type was described in 1933 as a malignant midfacial granuloma. The diagnosis of this rare affection is clinical and immunohistopathological. We report a case of NK/T cell lymphoma diagnosed at an advanced stage. Read More

    Cervicofacial non-tuberculous mycobacteria: A report of 30 cases.
    Eur Ann Otorhinolaryngol Head Neck Dis 2016 Apr 4;133(2):107-11. Epub 2016 Mar 4.
    Service d'ORL et chirurgie cervico-faciale, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France. Electronic address:
    Background: Mycobacterial infection is the most common cause of cervical granuloma, implicating either a tuberculous or a non-tuberculous mycobacterium (NTM). NTM is a ubiquitous organism, found in soil, water, food, etc. The most frequently implicated is Mycobacterium avium-intracellular. Read More

    [Central giant cell granuloma in children: Presentation of different therapeutic options].
    Rev Stomatol Chir Maxillofac Chir Orale 2016 Jun 19;117(3):142-6. Epub 2016 Feb 19.
    Service de chirurgie maxillo-faciale, stomatologie et chirurgie plastique de la face, université d'Auvergne, NHE, CHU de Clermont-Ferrand, 1, place Lucie-Aubrac, 63003 Clermont-Ferrand, France; UMR Inserm/UdA, U1107, neuro-dol, trigeminal pain and migraine, faculté de chirurgie dentaire, BP 10448, 63000 Clermont-Ferrand, France; Faculté de médecine, université d'Auvergne, Clermont université, BP 10448, 63000 Clermont-Ferrand, France.
    Central giant cell granuloma (CGCG) is a benign tumor that may be subdivided in a non-aggressive form and an aggressive form. In aggressive forms, tumor size and high recurrence risk need large surgical resections. In order to minimize surgical morbidity, especially in children, medical treatments acting on the tumor proliferation are currently being assessed: steroids (triamcinolone), anti-osteoclastic drugs (calcitonine, alendronate, denosumab), anti-angiogenic drugs (interferon α). Read More

    Granuloma Faciale and Eosinophilic Angiocentric Fibrosis: Similar Entities in Different Anatomic Sites.
    Appl Immunohistochem Mol Morphol 2017 03;25(3):213-220
    Departments of *Pathology †Dermatology, Medical Sciences School, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil ‡Department of Dermatology, Ealing Hospital, London, UK.
    Background: Eosinophilic angiocentric fibrosis (EAF) and granuloma faciale (GF) share several histopathologic features, including eosinophil-rich inflammation, microangiitis, and progressive fibrosis. Concurrent presentation of EAF and GF suggests a pathogenetic link between them.

    Objectives: To identify histologic findings that tell them apart and construe the pathogenetic mechanisms behind each morphologic variable, 14 immunohistochemical markers were used to study the cells subpopulations in 14 cases of GF and 3 cases of EAF. Read More

    Eosinophilic Angiocentric Fibrosis of Sinonasal Region: A Rare & Under Reported Entity.
    J Clin Diagn Res 2015 Nov 1;9(11):ED05-6. Epub 2015 Nov 1.
    Professor and Head, Department of Pathology, Dayanand Medical College and Hospital , Ludhiana, Punjab, India .
    Eosinophilic angiocentric fibrosis is a rare pathology of the sinonasal tract and the upper respiratory system characterised by fibrosis with poorly understood pathogenesis. A 47-year-old male presented with a swelling over the dorsum of the nose. The possibility of fungal granuloma was being suggested on Magnetic Resonance Imaging (MRI). Read More

    Granuloma faciale: a good therapeutic response with the use of topical tacrolimus.
    An Bras Dermatol 2015 Sep-Oct;90(5):735-7
    Fundação Alfredo da Matta, Manaus, AM, Brasil.
    Granuloma faciale is a rare dermatosis of chronic course, benign, usually asymptomatic, first described in 1945 by Wingley. It is characterized by the appearance of well-defined, single or multiple papules, plaques and nodules, predominantly located in sun-exposed areas, especially the face. In this work we report the case of a female patient, 58 years old, evolving for ten years with multiple erythematous-brownish and asymptomatic papules on the face, whose histological examination confirmed the diagnosis of granuloma faciale. Read More

    [Our experience about the use of resorbable plates in the treatment of craniostenosis].
    Rev Stomatol Chir Maxillofac Chir Orale 2015 Sep 17;116(4):245-9. Epub 2015 Jul 17.
    Service de neurochirurgie pédiatrique, hôpital neurologique et neurochirurgical Pierre-Wertheimer, 69500 Lyon, France.
    Introduction: The use of resorbable plates increases for craniosynostosis surgery. This material, based on polymere (PLA, PGA) can replace steel wire and non resorbable plates. A few studies present surgical results about the use of this material with a long follow-up. Read More

    Treatment of Laser Resistant Granuloma Faciale with Intralesional Triamcinolone acetonide and 5-Fluorouracil Combination Therapy.
    J Cutan Aesthet Surg 2015 Apr-Jun;8(2):111-3
    Dermatology Institute of Victoria, Melbourne, Australia.
    This report describes a sixty year old male with biopsy proven Granuloma Faciale (GF). The patient had been unsuccessfully treated with multiple therapies. A mixture 0. Read More

    Laryngeal tuberculosis diagnosed by stool sample cultures: a case report.
    J Med Case Rep 2015 Mar 31;9:74. Epub 2015 Mar 31.
    Assistance Publique-Hôpitaux de Marseille, CHU Nord, Pôle Infectieux, Institut Hospitalo-Universitaire Méditerranée Infection, 13015, Marseille, France.
    Introduction: Laryngeal tuberculosis is a rare and often misdiagnosed disease. Its diagnosis is based on the association of a laryngeal lesion and the microbiological detection of Mycobacterium tuberculosis. Stool cultures have recently been described as a useful tool in the diagnosis of atypical forms of tuberculosis. Read More

    Eosinophilic Skin Diseases: A Comprehensive Review.
    Clin Rev Allergy Immunol 2016 Apr;50(2):189-213
    Department of Dermatology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.
    Eosinophilic skin diseases, commonly termed as eosinophilic dermatoses, refer to a broad spectrum of skin diseases characterized by eosinophil infiltration and/or degranulation in skin lesions, with or without blood eosinophilia. The majority of eosinophilic dermatoses lie in the allergy-related group, including allergic drug eruption, urticaria, allergic contact dermatitis, atopic dermatitis, and eczema. Parasitic infestations, arthropod bites, and autoimmune blistering skin diseases such as bullous pemphigoid, are also common. Read More

    Off-label use of TNF-alpha inhibitors in a dermatological university department: retrospective evaluation of 118 patients.
    Dermatol Ther 2015 May-Jun;28(3):158-65. Epub 2015 Mar 3.
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Tumor necrosis factor-alpha (TNF)-alpha inhibitors are licensed for patients with severe refractory psoriasis and psoriatic arthritis. However, TNF-alpha inhibitors have also been used off-label for various recalcitrant mucocutaneous diseases. This study aimed to evaluate the efficacy and safety of TNF-alpha inhibitors used for off-label dermatological indications. Read More

    Chronic localized leukocytoclastic vasculitis: clinicopathological spectrum of granuloma faciale with and without extrafacial and mucosal involvement.
    G Ital Dermatol Venereol 2015 Feb 16;150(1):87-94. Epub 2015 Jan 16.
    Dermatology Unit, Department of Medical, Surgical Diagnostic and Pediatric Science, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy -
    Granuloma faciale (GF) is a rare cutaneous condition of unknown origin, that usually presents as one or more brown-purple papules, plaques and/or nodules, localized mostly on the face, although extrafacial lesions can also occur. Eosinophilic angiocentric fibrosis (EAF) is regarded as the mucosal counterpart of GF. Histologically, it has been described as a persistent leukocytoclastic vasculitis, with a dense polymorphous inflammatory infiltrate in the superficial and mid dermis, typically sparing the subpapillary dermis, the so called grenz zone. Read More

    The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism.
    J Bone Miner Res 2015 May;30(5):878-85
    Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS1138, Team Molecular Oral Pathophysiology, Cordeliers Research Center, University Paris-Diderot, University Paris-Descartes, and University Pierre and Marie Curie, Paris, France; Service de Chirurgie Maxillo-Faciale, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Unités de Formation et de Recherche (UFR) de Médecine Paris Descartes, Université Paris V, Paris, France; Centre de Références des Malformations de la Face et de la Cavité Buccale, Paris, France; Laboratoire de Physiopathologie Orale et Moléculaire, INSERM, UMRS 872, Equipe 5, Centre de Recherche des Cordeliers, Paris, France.
    Cherubism is a rare genetic disorder characterized by extensive growth of a bilateral granuloma of the jaws, resulting in facial disfigurement. Cherubism is caused by gain-of-function mutations in the SH3BP2 gene, leading to overactivation of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1)-dependent osteoclastogenesis. Recent findings in human and mouse cherubism have suggested that calcineurin inhibitors might be drug candidates in cherubism medical treatment. Read More

    [Cryptococcosis: a potential aetiology of facial ulceration].
    J Mycol Med 2014 Dec;24(4):e185-8
    Service de dermatologie et de vénérologie, CHU Yalgado, Ouédraogo, Burkina Faso.
    Unlabelled: Cutaneous cryptococcosis is an uncommon aetiology of chronic facial ulceration but which may be associated to a potentially lethal focus of cryptococcosis.

    Observation: A 35-year-old AIDS patient under antiretroviral therapy, presented with a chronic facial ulceration. Histopathological examination of a biopsy of the facial ulceration showed an inflammatory granuloma and masses of yeasts. Read More

    Granuloma faciale treated with topical dapsone: a case report.
    Dermatol Online J 2014 Aug 17;20(8). Epub 2014 Aug 17.
    University of Connecticut School of Medicine.
    Granuloma faciale (GF) is an unusual, treatment-resistant skin disorder that commonly affects the face. Several medical and surgical interventions are available that offer varying degrees of benefit. Both the condition and the treatment modalities can lead to significant disfigurement. Read More

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