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Immunity 2018 Dec 4. Epub 2018 Dec 4.

Center for Immunology, Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address:

Salmonella enterica (Se) bacteria cause persistent intracellular infections while stimulating a robust interferon-γ-producing CD4 T (Th1) cell response. We addressed this paradox of concomitant infection and immunity by tracking fluorescent Se organisms in mice. Se bacteria persisted in nitric oxide synthase (iNOS)-producing resident and recruited macrophages while inducing genes related to protection from nitric oxide. Read More

Nihon Rinsho 2016 Oct;74(10):1721-1728

Eosinophilic granulomatosis with polyangiitis(EGPA) is characterized by ANCA-related small vessel vasculitis with granuloma formation and chronic eosinophilic airway inflammation including severe asthma and nasal polyposis. Allergic bronchopulmonary mycosis(ABPM) is characterized by asthma, central bronchiectasis, eosinophilic mucoid impaction, and fungal sensitization. The accurate diagnosis in early stages for these severe type of asthma is very important for good prognosis. Read More

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, University of Miami, Jackson Memorial Hospital, Miami, Florida.

The catheter tip "granuloma" is a rare inflammatory mass that forms in about 3% of patients with an intradural catheter, most commonly from a morphine pump. It has also been seen with other narcotic pumps, narcotic-non-narcotic combinations, and baclofen pumps. Mass formation is associated with increased opioid dose and concentration. Read More

Scand J Immunol 2018 Dec 13:e12743. Epub 2018 Dec 13.

Sección de Patología Experimental, Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, México.

High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model during the first month there is a temporal control of bacillary growth, in co-existence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective cytokines (IFN-γ, TNF-α). Read More

Transpl Infect Dis 2018 Dec 12:e13037. Epub 2018 Dec 12.

Division of Infectious Diseases, Carver College of Medicine University of Iowa, Iowa City, IA, USA.

Q fever is uncommon in solid organ transplant (SOT) recipients. We describe a case of granulomatous lung disease as an unusual presentation of chronic Q fever in a kidney-pancreas transplant recipient. This article is protected by copyright. Read More

Diagn Cytopathol 2018 Dec 8. Epub 2018 Dec 8.

Department of ENT, Maulana Azad Medical College, Delhi, India.

Objective: Tuberculosis (TB) is a common granulomatous disease leading to high morbidity and mortality worldwide. Though rare, oral tuberculosis (OTB) may manifest during the primary and/or secondary stages of the illness. We studied the manifestations and incidence of oral granulomatous lesions (OGL) and OTB diagnosed on fine needle aspiration cytology (FNAC). Read More

J Cardiol Cases 2016 Oct 11;14(4):107-110. Epub 2016 Jul 11.

Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.

Cardiac involvement in sarcoidosis is related to lethal arrhythmias and is considered a serious condition. Because steroid therapy is an effective treatment, early diagnosis of cardiac sarcoidosis (CS) is of paramount importance in respect to improving prognosis. However, the diagnostic yield of histologic examination by endomyocardial biopsy (EMB) in CS is usually low. Read More

J Cardiol Cases 2015 Sep 17;12(3):72-73. Epub 2015 Jul 17.

Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.

Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.

Incorrect title of the article. Read More

Rheumatol Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, 45110, Ioannina, Greece.

Granuloma annulare (GA) is the most common non-infectious disease. Despite the fact that it is a benign disease, it can be associated with a variety of disorders and certain drugs including biological disease-modifying anti-rheumatic drugs (bDMARDs). A 50-year-old man with a history of rheumatoid arthritis refractory to methotrexate, hydroxychloroquine and infliximab was treated with tocilizumab (TCZ), an interleukin-6 receptor antagonist, 162 mg subcutaneously every week. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1247-S1248

Department of Pathology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey, ş.

J Med Case Rep 2018 Dec 11;12(1):365. Epub 2018 Dec 11.

Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.

Background: Epithelioid cell granuloma with caseating necrosis is a typical pathological finding in tuberculosis. While specific inflammation, including that related to tuberculosis, can induce caseating granuloma formation, there have been very few reports on the induction of caseating granuloma by non-specific inflammation. Chronic periapical periodontitis is usually related to bacterial biofilm formation as well as fungal or viral infection in the periapical lesion. Read More

J Cardiol Cases 2014 Jun 18;9(6):239-242. Epub 2014 Apr 18.

Cardiovascular, Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.

A 68-year-old woman with a history of hypertension was admitted to our hospital because of dyspnea during physical exertion. Echocardiography demonstrated impaired left ventricular systolic function, and her ejection fraction was reduced to 30%. Coronary angiography did not show significant stenosis. Read More

J Cardiol Cases 2011 Dec 20;4(3):e138-e142. Epub 2011 Aug 20.

Department of Pathology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.

A 49-year-old woman was referred to our hospital for uncontrollable heart failure. She had never been diagnosed as having sarcoidosis. Chest X-ray showed cardiomegaly without bilateral hilar lymphadenopathy. Read More

Rom J Morphol Embryol 2018 ;59(3):811-817

Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;

Introduction: Periapical granuloma is one of the most frequent periodontal pathology and belongs to the group named as apical periodontitis.

Materials And Methods: Out of 78 of diagnosed granulomas, we selected samples that we analyzed histologically and immunohistochemically.

Results: The histopathological aspect has been dominated by the presence of mononuclear cells of the lymphocyte and plasma cells type, showing the chronic aspect of the apical lesion. Read More

Rom J Morphol Embryol 2018 ;59(3):679-690

Discipline of Histology, Department of Morphological Sciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Read More

Front Immunol 2018 26;9:2717. Epub 2018 Nov 26.

Granulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.

Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial growth. (M. Read More

J Bone Jt Infect 2018 24;3(5):255-257. Epub 2018 Nov 24.

Service de Bactériologie-Hygiène hospitalière, CHU de Nantes, Nantes, France.

After rifampin and levofloxacin treatment for a bone infection, a pyogenic granuloma due to a newly described species, developed on the tibia former external fixator. This rifampin resistant bacterium, selected during treatment, harbored a mutation in the gene. This case illustrates the possible selection of resistant mutant most likely due to the bacterial burden and therefore the importance of adequate bone infection treatment. Read More

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):263-269

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

Objectives: Many community-based and hospital-based studies across the world have yielded contradictory results regarding association of positive serology and epilepsy. The present study was planned to analyze disease burden of epilepsy in rural community of North India and its association with exposure to in this part of the world.

Methods: A door-to-door screening survey was carried out in the rural community using a validated questionnaire for epilepsy by trained field workers, which was finally confirmed by trained neurologists. Read More

J Am Dent Assoc 2018 Dec 7. Epub 2018 Dec 7.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion of unknown cause. The purpose of this study is to present a series of LJSGH cases and compare the findings with the literature.

Methods: After obtaining institutional review board approval, cases of biopsy-proven LJSGH from 2008 through 2018 were retrieved from the University of Pittsburgh Oral Pathology Biopsy Service archives and reviewed. Read More

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Xinhua hospital affiliated to Shanghai Jiaotong University School of Medicine. Electronic address:

Objective: Extra-axial lymphoma involving the trigeminal nerve, an uncommon condition that presents as a trigeminal schwannoma, resulted in misdiagnosis and a flawed surgical strategy. We report two cases: a primary lymphoma of Meckel's cave and a metastasis lymphoma in the prepontine cistern arising from the supraclavicular lymph node.

Cases Report: The first patient presented with a 3-month history of persistent, sharp facial pain across the area innervated by the V2 nerve. Read More

Reprod Biol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, Texas Woman's University, Denton, Texas, USA. Electronic address:

Sperm granuloma may develop in the epididymis following vasectomy or chemical insults. Inflammation due to sperm granuloma causes abdominal and scrotal pain. Prolonged and persistent inflammation in the epididymis due to sperm granuloma may lead to infertility. Read More

Radiographics 2018 Dec 7:180108. Epub 2018 Dec 7.

From the Departments of Radiology (M.S., A.L., N.K.), Histopathology (A.B.), General Surgery (T.D.Y.), and Gastroenterology (R.K., S.K.S.), PGIMER, Chandigarh, India; and the Abdominal Imaging Section, Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Ave, Ottawa, ON, Canada, K1Y 4E9 (S.K., S.N., A.M.S.).

Encapsulating peritoneal sclerosis (EPS) is a rare but serious condition that results in (a) encapsulation of bowel within a thickened fibrocollagenous peritoneal membrane and (b) recurrent episodes of bowel obstruction. Although described by various names in the literature, the preferred term is encapsulating peritoneal sclerosis because it best describes the morphologic and histologic changes in this disorder. The etiology of EPS is multifactorial, with a wide variety of implicated predisposing factors that disrupt the normal physiologic function of the peritoneal membrane-prime among these factors being long-term peritoneal dialysis and bacterial peritoneal infections, especially tuberculosis. Read More

Respirol Case Rep 2019 Feb 28;7(2):e00390. Epub 2018 Nov 28.

Respiratory Department Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Pleural anthracosis is rare and, in most cases, is diagnosed incidentally or at autopsy. We report a 67-year-old man with pleural anthracosis. He was initially referred for possible tuberculous pleural effusion and had recurrent admissions for symptomatic pleural effusion, which increased with each subsequent episode. Read More

BMC Clin Pathol 2018 28;18:13. Epub 2018 Nov 28.

Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, 10000 Rabat, Morocco.

Background: Urinary schistosomiasis is a common parasitic disease in endemic countries.

Case Presentation: We report the case of a patient who was on a working trip to Mauritania. This parasitosis, suspected in the presence of hematuria and the notion of stay in an endemic zone, was confirmed by the presence of Schistosoma heamatobium eggs during the histological examination of the bladder biopsy performed after cystoscopy, highlighting a bilharzial granuloma and of course, the diagnosis was confirmed by the presence of eggs during the direct examination of the freshly collected urine. Read More

Clin Exp Dermatol 2018 Dec 1. Epub 2018 Dec 1.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA.

Am J Ophthalmol Case Rep 2019 Mar 14;13:9-12. Epub 2018 Nov 14.

MUHC - McGill University Ocular Pathology Laboratory, 1001 Boul Decarie, Block E, E02.6217, Montreal, QC, H4A 3J1, Canada.

Purpose: Granuloma annulare (GA) is a rare clinical entity that does not classically arise from the peri-orbital area in adults. The purpose of this case report is to present a 69-year-old female with GA of the orbit. As well, the pathological and immunohistochemical features of these tumors will be discussed. Read More

Indian Dermatol Online J 2018 Nov-Dec;9(6):409-413

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Background: Granuloma annulare (GA) is an uncommon dermatologic disorder that presents as annular, skin-colored to erythematous plaques. Histopathologically, it is characterized by palisaded histiocytic granulomas. A definitive diagnosis of GA is based on clinicopathologic correlation. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):227-231

Department of Cornea, The Eye Foundation Hospital, Coimbatore, Tamil Nadu, India.

Aim: The aim of this study is to compare the surgical outcomes of pterygium excision with conjunctival autograft using sutures, fibrin glue (tisseel), and autologous blood for the management of primary pterygium.

Patients And Methods: A retrospective study done in 681 eyes with primary nasal pterygium. Excision of the pterygium was performed followed by closure of the bare sclera with conjunctival autograft using interrupted 10-0 monofilament nylon sutures in 173 eyes (Group 1), fibrin glue (tisseel-baxter healthcare corporation, westlake village, ca-91362 USA) in 351 eyes (Group 2), and autologous blood in 157 eyes (Group 3). Read More

Nat Methods 2018 Dec 30;15(12):1098-1107. Epub 2018 Nov 30.

Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.

A central and critical structure in tuberculosis, the mycobacterial granuloma consists of highly organized immune cells, including macrophages that drive granuloma formation through a characteristic epithelioid transformation. Difficulties in imaging within intact animals and caveats associated with in vitro assembly models have severely limited the study and experimental manipulation of mature granulomas. Here we describe a new ex vivo culture technique, wherein mature, fully organized zebrafish granulomas are microdissected and maintained in three-dimensional (3D) culture. Read More

Cell Physiol Biochem 2018 30;51(4):1815-1829. Epub 2018 Nov 30.

Department of Molecular Biology, University of Duisburg-Essen, Essen,

Background/aims: Mycobacteria-induced diseases, especially tuberculosis, cause more than 1 million deaths each year, which is higher than any other single bacterial pathogen. Neutral sphingomyelinase 2 (Nsm2) has been implied in many physiological processes and diseases, but the role of Nsm2 in pathogen-host interactions and mycobacterial infections has barely been studied.

Methods: We investigated the role of the Nsm2/ceramide system in systemic infection of mice and murine macrophages with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) as a model for mycobacterial infection. Read More

Immunol Lett 2018 Nov 29;206:11-18. Epub 2018 Nov 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with Schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. Read More

Am J Otolaryngol 2018 Oct 29. Epub 2018 Oct 29.

Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.

Pyogenic granuloma (PG) may involve gingival mucosa (granuloma gravidarum) in pregnancy but rarely involves the airway. This case report is perhaps the only reported presentation of PG in the larynx causing hemoptysis at a late stage of pregnancy. On laryngoscopic exam, a vascular, right false vocal fold neoplasm was identified with pathological characteristics consistent with PG. Read More

Tuberculosis (Edinb) 2018 Dec 10;113:130-138. Epub 2018 Oct 10.

Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia; Department of Immunology, School of Biology, Moscow State University, Russia. Electronic address:

TB infection in mice develops relatively rapidly which interferes with experimental dissection of immune responses and lung pathology features that differ between genetically susceptible and resistant hosts. Earlier we have shown that the M. tuberculosis strain lacking four of five Rpf genes (ΔACDE) is seriously attenuated for growth in vivo. Read More

BMC Pediatr 2018 Dec 4;18(1):382. Epub 2018 Dec 4.

Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Nanlishi Road 56, Xicheng District, Beijing, People's Republic of China.

Background: Mediastinal teratoma is uncommon in children. It can be very difficult to diagnose especially in early stage. Rarely, teratoma may rupture into adjacent structures and lead to lung lesions or pleuritis. Read More

BMC Infect Dis 2018 Dec 4;18(1):619. Epub 2018 Dec 4.

Department of Hepatobiliary Pancreatic and Transplant surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Anisakid nematodes (Anisakis spp. or Pseudoterranova spp.) usually infect gastric or intestinal walls, while they rarely infect in extra-gastrointestinal sites of human body. Read More

Free Radic Biol Med 2018 Nov 27;131:50-58. Epub 2018 Nov 27.

Microbiology and Cell Biology, Centre for Infectious Disease Research (CIDR), Indian Institute of Science (IISc), CV Raman Av, Bangalore 12, India. Electronic address:

Mycobacterium tuberculosis (Mtb) survives under oxidatively and nitosatively hostile niches inside host phagocytes. In other bacteria, adaptation to these stresses is dependent upon the redox sensitive two component systems (e.g. Read More

Vestn Oftalmol 2018 ;134(5):32-38

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283.

Eye lesion in sarcoidosis is often the first and only sign of a disorder, which suggests a possible systemic disease. Currently sarcoidosis is considered a multisystemic granulomatous disease that requires multidisciplinary approach.

Purpose: To study the prevalence and clinical aspects of sarcoidosis eyes based on the representative sample of patients diagnosed with extraocular nonspecific granulomatous disease. Read More

Acta Neurochir (Wien) 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.

J Neurosurg 2018 Oct 1:1-11. Epub 2018 Oct 1.

OBJECTIVEIntracranial giant cell tumors (GCTs) are extremely rare neoplasms with dismal survival and recurrence rates. The authors aimed to confirm independent adverse factors for progression-free survival (PFS) and to propose an optimal treatment algorithm.METHODSThe authors reviewed the clinical data of 43 cases of intracranial GCTs in their series. Read More

Pediatr Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, Oregon Health & Science University, Portland, Oregon.

Reports detailing the acute formation of aluminum granulomas, which can cause persistent, intensely pruritic nodules secondary to the administration of aluminum-containing vaccines, are infrequently described in medical literature. To our knowledge, this is the first report describing the development of an aluminum granuloma causing a persistent, pruritic nodule at the injection site following the administration of the DTaP-IPV vaccine. We present the case of a 6-year-old girl who developed a severely pruritic subcutaneous nodule on her anterior right thigh at the injection site three weeks after the administration of the aluminum-containing DTaP-IPV (Kinrix) vaccine. Read More

Int J STD AIDS 2018 Nov 28:956462418813505. Epub 2018 Nov 28.

Department of Dermatology, Topiwala National medical College & B. Y. L. Nair Ch. Hospital, Mumbai, India.

Zhonghua Yi Xue Za Zhi 2018 Nov;98(44):3587-3591

Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, China.

To investigate the effect of different cryoablation time on tracheal traumatic granulation formation and its mechanism. A total of 32 rabbits were randomly assigned into four groups (A-D). Group A underwent tracheotomy alone. Read More

An Bras Dermatol 2018 Nov/Dec;93(6):878-880

Division of Dermatopathology, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro (RJ), Brazil.

Granuloma annulare is a relatively common, idiopathic, benign inflammatory dermatosis, with a varied clinical presentation that often makes diagnosis difficult. It mainly affects the extremities, such as the dorsa of the hands and feet, forearms and legs. Palmar and plantar regions are generally spared. Read More

JGH Open 2018 Apr 2;2(2):34-38. Epub 2018 Apr 2.

Department of Gastroenterology GB Pant Hospital New Delhi India.

Background And Aim: Esophageal involvement in tuberculosis (TB) is rare and is usually secondary. Data on esophageal TB are scarce. We aimed to analyze clinical and endoscopic features and outcomes of treatment in esophageal TB. Read More

Tuberk Toraks 2018 Sep;66(3):212-216

Department of Pathology, Faculty of Medicine, Karadeniz Teknik University, Trabzon, Turkey.

Introduction: Granulomatous lung disease (GLD) is caused by a wide range of conditions and it is challenge for pulmonologist. A detailed history of exposures is fundamental in GDL and has been found pivotal to reach a precise diagnosis.

Materials And Methods: Between September 2014 and December 2016, the distribution of patients diagnosed with granulomatous lymphadenitis in the mediastinal/hilar lymph nodes by endobronchial ultrasound (EBUS) or mediastinoscopy was analyzed. Read More

J Endod 2018 Dec;44(12):1783-1787

Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de Pernambuco, Camaragibe, Pernambuco, Brazil.

Introduction: The purpose of this study was to evaluate the expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor alpha (TNF-α) in periapical granuloma (PG) and radicular cyst (RC) samples and to correlate it with the type of lesion, the intensity of the inflammatory infiltrate, and the thickness of the epithelial lining.

Methods: A total of 51 cases of periapical lesions (25 PGs and 26 RCs) were subjected to morphologic analysis and immunohistochemical study. The anti-COX-2 and anti-TNF-α antibodies were applied using the immunoperoxidase technique. Read More

J Exp Ther Oncol 2018 Nov;12(4):291-294

MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.

Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More