Search Our Scientific Publications & Authors

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Southern Illinois University School of Medicine, Springfield, IL.

We present an adult woman with subcutaneous nodules without any signs or symptoms of rheumatoid arthritis. These nodules are believed to be pseudorheumatoid nodules, which are considered a deep form of granuloma annulare. This case is unique because these are typically found in children and have rarely been reported in adults. Read More

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

Dermatol Ther 2020 Jun 25. Epub 2020 Jun 25.

Department of Dermatovenereology, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia.

Clin Case Rep 2020 Jun 23;8(6):1065-1068. Epub 2020 Mar 23.

Good Health Clinic Tavernier Florida.

The only myeloproliferative neoplasm associated with generalized granuloma annulare (GA) is chronic myelogenous leukemia (CML). We present the first reported case of GA in a patient with essential thrombocythemia (ET). Future work investigating the shared pathophysiology of GA-associated CML and ET may improve our understanding of GA pathophysiology and treatment. Read More

JAAD Case Rep 2020 Jun 24;6(6):534-536. Epub 2020 Apr 24.

Department of Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, Tennessee.

Indian Dermatol Online J 2020 Mar-Apr;11(2):288-290. Epub 2020 Mar 9.

Department of Dermatology, Venereology, and Leprosy, Dr. KN Barua Institute of Dermatological Sciences, Guwahati, Assam, India.

A 60-year-old male patient presented with a solitary pink plaque over the inner aspect of the left forearm of 4 years duration. The lesion was persistent and unresponsive to treatment. A skin biopsy was done with differential diagnosis of lupus vulgaris, tuberculoid leprosy, and granuloma annulare. Read More

J Cutan Pathol 2020 May 29. Epub 2020 May 29.

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Dermatology 2020 May 13:1-6. Epub 2020 May 13.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland,

Background: Granuloma annulare is a chronic noninfectious granulomatous skin condition with variable clinical presentations. Generalized granuloma annulare, defined as widespread disease with >10 skin lesions, accounts for 15% of all cases. Numerous associated diseases have been controversially discussed, most importantly diabetes mellitus, dyslipidemia, thyroid disease, malignancy and systemic infections. Read More

JAMA Dermatol 2020 May 13. Epub 2020 May 13.

Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands.

Australas J Dermatol 2020 May 10. Epub 2020 May 10.

Pitney Dermatology, Toowong, Brisbane, Queensland, Australia.

Background: The therapeutic value of ultraviolet A1 (UVA1) phototherapy has been acknowledged for many years. Initially developed predominately for experimental and diagnostic purposes, it was subsequently recognised as a beneficial therapeutic modality in atopic dermatitis and localised scleroderma, and more recently a variety of sclerosing and fibrosing dermatoses, T-lymphocyte mediated disorders, both inflammatory and infiltrative, and several predominately dermal processes previously unresponsive to current therapies.

Methods: We present a retrospective evaluation of outcomes and treatment tolerability in adult patients using a low dose (30 joules/cm ), regimen administered in our private dermatologic practice, between 2006 and December 2019. Read More

J Dermatol 2020 Jun 22;47(6):677-679. Epub 2020 Apr 22.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Subcutaneous granuloma annulare is a rare variant of granuloma annulare. It mostly presents as painless subcutaneous nodule(s) with or without annular lesions on the lower legs and scalp of children. We herein report a case of a 5-year-old Japanese girl with subcutaneous granuloma annulare on the right heel. Read More

Pediatr Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

We present three children who presented with papules and plaques over the knuckles, mimicking Gottron's papules of juvenile dermatomyositis, as well as subcutaneous nodules over the joints of the extremities that were initially thought to represent calcinosis cutis. However, thorough clinical and laboratory evaluation, as well as imaging, failed to support this diagnosis. Skin biopsies were consistent with a diagnosis of subcutaneous granuloma annulare. Read More

J Cutan Pathol 2020 Apr 12. Epub 2020 Apr 12.

Department of Dermatology, University of California, San Francisco, California, USA.

Background: Granuloma annulare (GA) is a skin disorder of uncertain etiology. Patch (type) GA is an uncommon variant of GA with a paucity of data characterizing it. We describe the features of 23 cases of patch GA. Read More

Dermatol Ther 2020 May 4;33(3):e13375. Epub 2020 May 4.

Dermatology Department, Ankara University School of Medicine, Ankara, Turkey.

Indian J Dermatol Venereol Leprol 2020 04 3. Epub 2020 Apr 3.

Department of Dermatology, University General Hospital of Valencia, Valencia, Spain.

J Neuroophthalmol 2020 Mar 31. Epub 2020 Mar 31.

Faculty of Medicine (PN), University of Toronto, Toronto, Canada; Department of Ophthalmology and Vision Sciences (JAM), University of Toronto, Toronto, Canada; and Division of Neurology (JAM), Department of Medicine, University of Toronto, Toronto, Canada.

Yale J Biol Med 2020 03 27;93(1):187-195. Epub 2020 Mar 27.

Department of Dermatology, Yale School of Medicine, New Haven, CT.

Certain inflammatory disorders are characterized by macrophage activation and accumulation in tissue; sometimes leading to the formation of granulomas, as in sarcoidosis. These disorders are often difficult to treat and more effective, molecularly targeted therapies are needed. Recent work has shown that overproduction of inflammatory cytokines, such as interferon gamma (IFN-γ) leading to constitutive activation of the JAK-STAT pathway may be a conserved feature of these disorders. Read More

J Eur Acad Dermatol Venereol 2020 Mar 26. Epub 2020 Mar 26.

Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, US.

Objectives: Evaluate the efficacy of sulfasalazine in treating GA, AEGCG, and IGD.

Methods: Sixteen patients were identified with granulomatous disease who were treated with sulfasalazine between September 2015 and September 2019. Outcomes were based on patients' and providers' subjective evaluations. Read More

Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):314-316

Department of Pathology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.

Ann Dermatol Venereol 2020 Apr 11;147(4):271-278. Epub 2020 Mar 11.

Clinique dermatologique, université de Strasbourg et hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

Background: Granuloma annulare (GA) is a benign granulomatous skin disorder that is generalized (GGA) in 15 % of cases. Although many case reports describe a relationship between GGA and systemic diseases, few large series have been published, and their association is debated. We present herein a series of GGA in order to describe their clinical and histological features. Read More

JAAD Case Rep 2020 Mar 19;6(3):184-186. Epub 2020 Feb 19.

Naval Hospital Guam, Agana Heights, Guam.

Am J Dermatopathol 2020 Mar;42(3):157-164

Dermatology Specialist, Department of Dermatology, Hospital de Santa Maria, Lisboa, Portugal.

Granulomatous skin diseases comprise an extensive group of pathologies whose diagnosis usually requires a histopathological examination. At this level, various types of granulomas can be distinguished, namely tuberculoid, sarcoid, necrobiotic, suppurative, xanthogranuloma, and foreign-body granulomas. This study aimed to determine the frequency and pattern of different granulomatous skin lesions in the Dermatopathology Department of Hospital de Santa Maria (Lisboa, Portugal). Read More

Indian Dermatol Online J 2020 Jan-Feb;11(1):83-86. Epub 2019 Sep 26.

Department of Dermatology and Venereology, Centro Hospitalar e Universitário de São João EPE, Porto, Portugal.

Necrobiotic xanthogranuloma (NXG) is a rare form of inflammatory granulomatous disease of the skin characterized by the presence of pruritic to painful lesions, generally located in the periorbital area, although trunk and proximal extremities may also be involved. We report a case of a 69-year-old male patient with extensive involvement of the trunk, upper and lower extremities, and an associated gamma monoclonal gammopathy. The skin biopsy was consistent with the diagnosis of NXG. Read More

J Cosmet Dermatol 2020 Feb 6. Epub 2020 Feb 6.

Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Botulinum toxin is generally considered safe and has been used in constantly expanded cosmetic and therapeutic indications. However, long-term side effects such as granulomatous reactions have been associated with this drug.

Aims: We aim to evaluate a rare reaction to Botulonium toxin A injection. Read More

JAAD Case Rep 2020 Feb 24;6(2):133-135. Epub 2020 Jan 24.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

J Dermatol 2020 Apr 3;47(4):e117-e119. Epub 2020 Feb 3.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.

Endocr Metab Immune Disord Drug Targets 2020 Jan 28. Epub 2020 Jan 28.

Dermatology Section, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Nickel is the most common cause of contact allergy in general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD). Nickel Allergy: ACD from nickel is a typical type IV hypersensitivity. Nickel allergy is mostly caused by non-occupational exposure, such as jewelry and clothing decorations, metal tools, medical devices (mainly orthopedic and orthodontic implants, cardiovascular prosthesis), eyeglasses, utensils, keys, pigment for paint, cosmetics and food (mainly legumes, chocolate, salmon, peanuts). Read More

JAAD Case Rep 2020 Jan 30;6(1):69-71. Epub 2019 Dec 30.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

Eur J Dermatol 2019 12;29(6):677-678

Department of Dermatology, Beijing Tsinghua Changgung Hospital, Tsinghua University, 168 Litang Rd, Beijing 102218, China.

J Am Acad Dermatol 2020 Jul 20;83(1):63-70. Epub 2019 Dec 20.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, New York; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York. Electronic address:

Background: Granuloma annulare (GA) is an inflammatory skin disorder. Localized GA is often self-resolving, but generalized GA is often recalcitrant to treatments. There are no targeted treatments for GA, largely due to lack of mechanistic understanding. Read More

BMJ Case Rep 2019 Dec 16;12(12). Epub 2019 Dec 16.

Department of Dermatology and Venereology, Hospital de Braga, Braga, Portugal.

Elastolytic giant cell granuloma (EGCG), also known as actinic granuloma, is an uncommon granulomatous dermatosis usually characterised by asymptomatic annular plaques on sun-exposed skin. Its aetiology is not fully elucidated, but actinic damage has been considered the main causal factor. Atypical variants with lesions in a non-photodistributed pattern are rare and often related to a systemic disorder, suggesting a more complex pathogenesis and demanding for a screening work-up. Read More

JAAD Case Rep 2019 Nov 24;5(11):976-978. Epub 2019 Oct 24.

Department of Dermatology, Saint Joseph Mercy Ann Arbor Hospital, Ypsilanti, Michigan.

J Dermatol 2020 Feb 24;47(2):e71-e72. Epub 2019 Nov 24.

Department of Dermatology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

J Family Med Prim Care 2019 Oct 31;8(10):3419-3421. Epub 2019 Oct 31.

Department of Medicine, S.N. Medical College, Agra, Uttar Pradesh, India.

Granuloma annulare (GA) is usually a self-limited, benign granulomatous disease of the dermis and subcutaneous tissue. It's generalized or disseminated form is associated with underlying diabetes mellitus and at times it precedes the sign and symptoms of diabetes mellitus. We are reporting a case of a 56-year-old female, who is a known case of type 2 diabetes mellitus she presented to us with symmetric lesions on her trunk, arms, and legs. Read More

Cureus 2019 Sep 9;11(9):e5598. Epub 2019 Sep 9.

Rheumatology, University of Connecticut Health Center, Farmington, USA.

Tumor necrosis factor (TNF) inhibitors are used for treatment of different autoimmune diseases. Interestingly they are also being noted to cause autoimmune side effects such as vasculitis, systemic lupus erythematosus, interstitial lung disease, etc. We describe one such case of granuloma annulare being treated with Adalimumab, who then developed pulmonary-renal syndrome form anti-neutrophilic cytoplasmic antibody (ANCA)-induced vasculitis. Read More

Am J Ther 2019 Oct 25. Epub 2019 Oct 25.

Department of Dermatology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Case Rep Dermatol Med 2019 7;2019:5485034. Epub 2019 Oct 7.

Department of Pathology, Universal College of Medical Sciences-Teaching Hospital, Ranigaon, Bhairahawa 32900, Nepal.

Granuloma Multiforme (GM) is a reactive skin disorder with annular lesion and focal necrobiosis. It was first described in Nigeria (Africa), since than it was mostly described from various regions of Africa where leprosy was endemic. Outside Africa, this disease is rarely reported. Read More

Cutis 2019 Aug;104(2):E15-E17

Division of Dermatology, Children's Mercy Hospital, Kansas City, Missouri, USA.

Eur J Dermatol 2019 Oct;29(5):562-564

Department of Dermatology, Kizawa Memorial Hospital, 590 Shimokobi, Kobicho, Minokamo, Gifu 505-8503, Japan.

J Dermatol 2019 Dec 25;46(12):e476-e477. Epub 2019 Sep 25.

Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.

Acta Dermatovenerol Alp Pannonica Adriat 2019 Sep;28(3):103-105

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Introduction: Teledermatology is a useful tool for underserved areas. However, because it is not without costs, knowledge of the burdens incurred by teledermatology treatment would be valuable for future types of management.

Methods: All specialist dermatology services in the Faroe Islands have been provided by our department through a mix of standard and teledermatology consultations. Read More

Case Rep Dermatol 2019 May-Aug;11(2):233-238. Epub 2019 Aug 6.

Private Practice Oakview Dermatology, Springfield, Ohio, USA.

We present a 54-year-old Caucasian female with a history of diabetes mellitus, multiple sclerosis, and ulcerative colitis who presented with nail dystrophy, polyarthralgia in her hands and hips, myalgia, proximal myopathy, dactylitis, and psoriasiform-appearing progressive, painful plaques on the dorsal aspect of her hands. Histologic examination of the lesion from the left index finger revealed an interstitial and necrobiotic granulomatous dermatitis with connective tissue mucin deposition associated with a perivascular lymphoid infiltrate. Additionally, there was focal transepidermal elimination of the necrobiotic material. Read More

Paediatr Child Health 2019 Sep 7;24(6):366-367. Epub 2019 Mar 7.

Department of Paediatrics, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia.

JAAD Case Rep 2019 Sep 29;5(9):749-751. Epub 2019 Aug 29.

Department of Dermatology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina.

Presse Med 2019 Oct 27;48(10):1200-1201. Epub 2019 Aug 27.

Dermatology Department, Habib Thameur Hospital, 1008 Tunis, Tunisia; Research Unit "Genodermatoses and cancers" LR12SP03, 1008 Tunis, Tunisia.

J Dermatolog Treat 2019 Sep 10:1-2. Epub 2019 Sep 10.

Dermatology Associates of West Michigan, Michigan State University College of Osteopathic Medicine , Grand Rapids , MI , USA.

Granuloma annulare is frequently described in association with numerous systemic conditions and is often refractory to treatment. This retrospective review explored a large patient cohort to further strengthen associated comorbid conditions and assess response to different treatments in patients with granuloma annulare. This study found that patients with granuloma annulare frequently carried a diagnosis of hypothyroidism. Read More

Front Immunol 2019 8;10:1918. Epub 2019 Aug 8.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

The impressive potential of biologics has been demonstrated in psoriasis, hidradenitis suppurativa, and urticaria. Numerous biologicals are entering the field for a restricted number of skin disorders. Off-label use of biologics in other recalcitrant skin diseases has increased. Read More

JAMA Dermatol 2019 Aug 21. Epub 2019 Aug 21.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Afr J Infect Dis 2019 3;13(2):1-12. Epub 2019 Jul 3.

London North West Healthcare NHS Trust, London, UK.

Background: Granuloma annulare (GA) is a benign inflammatory dermatosis of unknown cause, of which generalised granuloma annulare (GGA) is a subtype that tends to be resistant to treatment. Various antibiotics have been used to treat GGA, the most recent being combination therapy with rifampicin, ofloxacin and minocycline (ROM). This study aims to explore the efficacy of antibiotics in treating GGA, and whether antibiotics may be useful in children with GGA. Read More

Cutis 2019 Jun;103(6):E14-E15

Division of Dermatology, University of Ottawa, Ontario, Canada.