26,140 results match your criteria Granulocytopenia


Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective.

Pharmacogenomics 2019 Feb 15. Epub 2019 Feb 15.

MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia. We now know that the genetic etiology of clozapine-associated neutropenia is complex and is likely to involve variants from several genes including HLA-DQB1, HLA-B and SLCO1B3/SLCO1B7. Read More

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http://dx.doi.org/10.2217/pgs-2018-0188DOI Listing
February 2019

[Perioperative use of metamizole and other nonopioid analgesics in children : Results of a survey].

Anaesthesist 2019 Jan 24. Epub 2019 Jan 24.

Klinik für Anästhesiologie und Schmerztherapie, Universitätsklinik Bern, Inselspital, Universität Bern, Freiburgstrasse, 3010, Bern, Schweiz.

Background: Nonopioid analgesics are frequently used for perioperative pain management in children. In many countries, the nonopioid metamizole (dipyrone) is administered as an alternative to paracetamol and traditional NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen and diclofenac; however, concerns over possible life-threatening adverse events (agranulocytosis) have prompted a debate over the use of metamizole.

Objective: To investigate current practice and use of nonopioid analgesics, particularly of metamizole in children younger than 14 years, in the perioperative setting. Read More

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http://dx.doi.org/10.1007/s00101-018-0532-4DOI Listing
January 2019
1 Read

[Mitoxantrone-cytarabine-etoposide induction therapy in children with acute myeloid leukemia: a single-center study of complications and clinical outcomes].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):24-28

Department of Pediatric Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Objective: To investigate the complications and clinical outcome of children with acute myeloid leukemia (AML) undergoing mitoxantrone-cytarabine-etoposide (MAE) induction therapy.

Methods: A total of 170 children with AML were given MAE induction therapy, and the complications and remission rate were analyzed after treatment.

Results: The male/female ratio was 1. Read More

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January 2019
4 Reads

Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Monter Cancer Center-Division of Hematology Oncology, Northwell Health, Lake Success, New York, USA.

A 26-year-old man with history of schizophrenia was admitted for neutropaenia. He was started on clozapine 3 months prior to admission. As a result he had weekly monitoring of his blood counts and on day of admission was noted to have an absolute neutrophil count (ANC) of 450 cells/μL. Read More

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http://dx.doi.org/10.1136/bcr-2018-226016DOI Listing
January 2019
6 Reads

Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.

Biochem Pharmacol 2019 Jan 14. Epub 2019 Jan 14.

Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Centre of Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address:

Metamizole is an analgesic and antipyretic, but can cause neutropenia and agranulocytosis. We investigated the toxicity of the metabolites N-methyl-4-aminoantipyrine (MAA), 4-aminoantipyrine (AA), N-formyl-4-aminoantipyrine (FAA) and N-acetyl-4-aminoantipyrine (AAA) on neutrophil granulocytes and on HL60 cells (granulocyte precursor cell line). MAA, FAA, AA, and AAA (up to 100 µM) alone were not toxic for HL60 cells or granulocytes. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.01.011DOI Listing
January 2019
2 Reads

Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study.

Thyroid 2019 Feb;29(2):193-201

3 Department of Community Medicine and Epidemiology, Clalit Health Services, Haifa, Israel.

Background: Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. Read More

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http://dx.doi.org/10.1089/thy.2018.0274DOI Listing
February 2019
1 Read

Acute agranulocytosis when switching from risperidone to paliperidone.

Aust N Z J Psychiatry 2019 Jan 14:4867418821441. Epub 2019 Jan 14.

Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1177/0004867418821441DOI Listing
January 2019
2 Reads

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019
3 Reads

5-HT deletion protects against Clozapine-induced hyperglycemia.

J Pharmacol Sci 2019 Feb 18;139(2):133-135. Epub 2018 Dec 18.

National Centre for Biological Sciences, TIFR, GKVK Campus, Bellary Road, Bengaluru, India; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. Electronic address:

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.015DOI Listing
February 2019
1 Read

A qualitative exploration of clozapine prescribing and monitoring practices in the Arabian Gulf countries.

Asian J Psychiatr 2019 Jan 21;39:93-97. Epub 2018 Dec 21.

Hamad Medical Corporation, Mental Health Hospital, Doha, Qatar.

Clozapine is considered as the first line antipsychotic for treatment resistant schizophrenia (TRS). Worldwide reports indicate an overall underutilization of clozapine in patients experiencing TRS. This study aims to understand the prescribing practices, monitoring strategies and barriers to the use of clozapine in the Arabian Gulf (AG) region. Read More

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http://dx.doi.org/10.1016/j.ajp.2018.12.011DOI Listing
January 2019
1 Read

Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report.

BMC Infect Dis 2018 Dec 29;18(1):706. Epub 2018 Dec 29.

Department of Emergency Internal Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, People's Republic of China.

Background: Blood infection with Candida glabrata often occurs in during severe acute pancreatitis (SAP). It complicate severe agranulocytosis has not been reported.

Case Presentation: We present a case where a SAP patient presenting with a sudden hyperpyrexia was treated for 19 days. Read More

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http://dx.doi.org/10.1186/s12879-018-3623-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310945PMC
December 2018
2 Reads
2.613 Impact Factor

Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report.

J Med Case Rep 2018 Dec 29;12(1):384. Epub 2018 Dec 29.

Teaching Hospital Kurunegala, Kurunegala, Sri Lanka.

Background: Bacteremia following Staphylococcus aureus is a serious clinical condition which is often associated with distant metastatic infections. One of the most dreaded complications of Staphylococcus aureus bacteremia is infective endocarditis. Cloxacillin is a common antibiotic prescribed for suspected staphylococcal infections and confirmed methicillin-sensitive Staphylococcus aureus infections. Read More

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http://dx.doi.org/10.1186/s13256-018-1933-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310943PMC
December 2018
1 Read

Levamisole-induced vasculitis.

JAAPA 2019 Jan;32(1):23-27

At the John S. Dunn Burn Center at Memorial Hermann Hospital, part of the University of Texas Health Science Center at Houston, Tex., Tonya C. George is an assistant professor of surgery, Daniel J. Freet is an assistant professor, James M. Cross is a professor of surgery, and Todd F. Huzar is an associate professor of surgery. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Levamisole is a veterinary antihelminthic, chemotherapeutic agent, and immunomodulator that also is used as an adulterant and cutting agent in cocaine distribution. This drug may potentiate the sympathomimetic actions of cocaine and can cause neutropenia, agranulocytosis, purpuric retiform lesions, and skin necrosis. This article describes two cases of suspected levamisole-induced vasculitis. Read More

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http://dx.doi.org/10.1097/01.JAA.0000547746.08181.f7DOI Listing
January 2019
1 Read

Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report.

Transplant Proc 2018 Dec 18;50(10):3925-3927. Epub 2018 Apr 18.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Azathioprine (AZA) is the drug recommended for the continuation of immunosuppressive treatment after renal transplant in women during pregnancy.

Case Report: A 37-year-old Japanese female developed agranulocytosis and severe alopecia after initiation of AZA (50 mg), used as an alternative to mycophenolate mofetil (MMF, 1000 mg) therapy in anticipation of a planned pregnancy. Within 4 days of the initiation of AZA therapy, the patient developed a high fever, leucopenia, and cranial alopecia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.039DOI Listing
December 2018
1 Read

Fatal Invasive Pulmonary Aspergillosis Associated with Nonspecific Interstitial Pneumonia: An Autopsy Case Report.

Intern Med 2018 15;57(24):3619-3624. Epub 2018 Dec 15.

Department of Respiratory Medicine, Toho University Omori Medical Center, Japan.

Invasive pulmonary aspergillosis (IPA) usually occurs in patients with severe immunodeficiencies involving neutropenia. Underlying lung disease is a well-known risk factor of IPA; however, interstitial lung disease has not been recognized as a risk factor of IPA. We herein report a patient with fibrotic nonspecific interstitial pneumonia who experienced IPA without neutropenia. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/57/24/
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http://dx.doi.org/10.2169/internalmedicine.1144-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355419PMC
January 2019
11 Reads

Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky.

Prim Care Companion CNS Disord 2018 Nov 29;20(6). Epub 2018 Nov 29.

PSTAR Clinic, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.4088/PCC.18l02282DOI Listing
November 2018

Diagnostic workup in front of an adult neutropenia.

Ann Biol Clin (Paris) 2018 Dec;76(6):651-658

Service de médecine interne, Centre hospitalier de Royan, Vaux-sur-mer, France, Groupement de coopération sanitaire de Saintonge, Laboratoire inter-hospitalier de biologie médicale, Centres hospitaliers de Saint-Jean-d'Angély, Saintes, Royan et Jonzac, Saint-Jean-d'Angély.

Adult neutropenia, defined as a blood neutrophil count below 1.5 G/L, is a common condition. The most common cause of acute neutropenia is a drug-related reaction or an acute infectious disease. Read More

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http://dx.doi.org/10.1684/abc.2018.1393DOI Listing
December 2018

Complete remission of pure white cell aplasia associated with thymoma after thymectomy and cyclosporine administration.

Int J Hematol 2018 Dec 9. Epub 2018 Dec 9.

Department of Haematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

We present the case of a 63-year-old male with pure white cell aplasia (PWCA), a rare complication of thymoma, who was successfully treated with cyclosporine A (CyA) and thymectomy. The patient presented with high fever and agranulocytosis. Complete blood count revealed a white blood cell count of 0. Read More

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http://dx.doi.org/10.1007/s12185-018-02573-yDOI Listing
December 2018
1 Read

[Agranulocytosis during therapy of chronic myeloid leukemia lymphoid blast crisis with dasatinib].

Rinsho Ketsueki 2018;59(11):2438-2440

Department of Hematology, Japan Community Health Care Organization, Kyoto Kuramaguchi Medical Center.

A 61-year-old female was diagnosed with a lymphoid crisis of chronic myeloid leukemia (CML) in February 201X and started chemotherapy combined with dasatinib (DAS). After 1 month of initiating second consolidation therapy, the neutrophils decreased to 1%, bone marrow examination revealed large granular lymphocytes (LGL) at 13%, and complete cytogenetic remission was attained (CCyR). Suspecting DAS-induced agranulocytosis, DAS was discontinued. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/11/59_2438/
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http://dx.doi.org/10.11406/rinketsu.59.2438DOI Listing
January 2018
9 Reads

Patterns of Use of Docetaxel-Containing Adjuvant Chemotherapy Among Chinese Patients with Operable Breast Cancer: A Multicenter Observational Study.

Adv Ther 2019 Jan 3;36(1):131-146. Epub 2018 Dec 3.

Jiangsu Province Hospital (The First Affiliated Hospital of Nanjing Medical University), Nanjing, China.

Introduction: Adjuvant docetaxel-based chemotherapy is frequently used in the treatment of operable early breast cancer (EBC). This study investigated patterns of docetaxel use in patients with EBC in real-world clinical practice in China.

Methods: This was a multicenter, prospective, observational study of Chinese women with operable breast cancer in tier 1 non-oncology-specific hospitals and other city hospitals in China. Read More

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http://dx.doi.org/10.1007/s12325-018-0841-7DOI Listing
January 2019
2 Reads

The role of temperature in the detection and diagnosis of neutropenic sepsis in adult solid tumour cancer patients receiving chemotherapy.

Eur J Oncol Nurs 2018 Dec 21;37:12-18. Epub 2018 Oct 21.

University of Sheffield, Weston Park Hospital, Witham Road, Sheffield, S10 2SJ, UK.

Purpose: The primary aim of this study was to examine the value of temperature as a diagnostic and prognostic indicator of infection and sepsis in neutropenic patients. A secondary aim was to gain insight into the presenting symptoms reported by these patients at home or on their initial admission assessment.

Methods: A cohort study was carried out using a case note review of 220 emergency admissions to a regional cancer centre. Read More

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http://dx.doi.org/10.1016/j.ejon.2018.10.001DOI Listing
December 2018
6 Reads

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report.

Clin Psychopharmacol Neurosci 2018 Nov;16(4):501-504

Departments of Child Hematology and Oncology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient's own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified into two groups according to serological features and secondary causes including drugs induced hemolytic anemia. Drugs induced autoimmune hemolytic anemia is very rare in pediatric patients. Read More

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http://dx.doi.org/10.9758/cpn.2018.16.4.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245293PMC
November 2018
1 Read

Effects of Clozapine on the Gut: Cross-Sectional Study of Delayed Gastric Emptying and Small and Large Intestinal Dysmotility.

CNS Drugs 2019 Jan;33(1):81-91

Department of Psychological Medicine, University of Otago, PO Box 7343, Wellington, 6242, New Zealand.

Background: Gastrointestinal hypomotility in people taking clozapine is common, poorly understood and potentially dangerous. It causes distress and sometimes sudden death, with greater associated morbidity than the better known adverse effect of clozapine, agranulocytosis. Neither the mechanism nor prevalence of clozapine-induced gastrointestinal hypomotility is well understood. Read More

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http://dx.doi.org/10.1007/s40263-018-0587-4DOI Listing
January 2019
12 Reads

Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma.

N Engl J Med 2018 11;379(19):1811-1822

From the National and Kapodistrian University of Athens, Athens (M.A.D.); Karol Marcinkowski University of Medical Sciences, Poznań (D.D.), and Silesian Medical University, Katowice (S.G.) - both in Poland; University Hospital, Nantes (P.M.), and Centre Hospitalier Universitaire de Poitiers-La Milétrie, Poitiers (X.L.) - both in France; National Hospital Organization Disaster Medical Center (N.T.) and the Japanese Red Cross Medical Center (K.S.), Tokyo, and Ibaraki Prefectural Central Hospital, Kasama (M.H.) - all in Japan; Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal (R.L.); Heidelberg University Hospital, Heidelberg, Germany (M.S.R.); Dana-Farber Cancer Institute, Boston (P.G.R.); Bristol-Myers Squibb, Princeton, NJ (M.P.M., Y.-M.J., S.G.S., M.R., B.R.); and Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra (IDISNA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Pamplona, Spain (J.S.-M.).

Background: The immunostimulatory monoclonal antibody elotuzumab plus lenalidomide and dexamethasone has been shown to be effective in patients with relapsed or refractory multiple myeloma. The immunomodulatory agent pomalidomide plus dexamethasone has been shown to be effective in patients with multiple myeloma that is refractory to lenalidomide and a proteasome inhibitor.

Methods: Patients with multiple myeloma that was refractory or relapsed and refractory to lenalidomide and a proteasome inhibitor were randomly assigned to receive elotuzumab plus pomalidomide and dexamethasone (elotuzumab group) or pomalidomide and dexamethasone alone (control group). Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805762
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http://dx.doi.org/10.1056/NEJMoa1805762DOI Listing
November 2018
17 Reads

[Therapeutic Effect and Adverse Events of Ramucirumab in Patients with Gastric Cancer in Our Hospital].

Gan To Kagaku Ryoho 2018 Oct;45(10):1549-1551

Dept. of Surgery, Gifu Municipal Hospital.

From January 2016 through December 2017, 18 patients received paclitaxel plus ramucirumab combination therapy and 1 patient received ramucirumab monotherapy. Thus, a total of 19 patients were analyzed in terms of both therapeutic effect and adverse events. The response evaluation of the targeted lesion was as follows; CR: 0, PR: 1, SD: 16, PD: 2. Read More

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October 2018
2 Reads

[Examination of Fever Risk Factors after Prophylaxis with G-CSF].

Gan To Kagaku Ryoho 2018 Oct;45(10):1431-1434

Dept. of Pharmacy, Jichi Medical University Hospital.

Febrile neutropenia is a serious adverse drugreaction to cancer chemotherapy. Prophylactic administration of granulocyte colony-stimulatingfactor (G-CSF)is recommended in patients who require cancer chemotherapy associated with a risk of febrile neutropenia or intense treatment. However, we had patients who developed fever after prophylactic administration of G-CSF. Read More

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October 2018
1 Read

Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency.

Allergy Asthma Clin Immunol 2018 22;14:65. Epub 2018 Oct 22.

1Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC Australia.

Background: Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune disease activity, in inflammatory conditions like relapsing and remitting multiple sclerosis. Here, we present the first report of agranulocytosis with daclizumab therapy in a patient with relapsing and remitting multiple sclerosis. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0272-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196561PMC
October 2018
17 Reads

A case of Alemtuzumab-induced neutropenia in multiple sclerosis in association with the expansion of large granular lymphocytes.

BMC Neurol 2018 Oct 29;18(1):178. Epub 2018 Oct 29.

1st Department of Neurology, Medical School of Athens, National & Kapodistrian University, Aeginition Hospital, Athens, Greece.

Background: Alemtuzumab has been demonstrated to reduce the risks of relapse and accumulation of sustained disability in Multiple Sclerosis (MS) patients compared to β-interferon. It acts against CD52, leading primarily to lymphopenia. Recent data have shown that mild neutropenia is observed in 16% of treated MS-patients whereas severe neutropenia occurred in 0. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-018-1183-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206708PMC
October 2018
9 Reads

An atypical occurrence of Aspergillosis in leukemic patient: Brief description of a clinical case.

J Mycol Med 2018 Dec 23;28(4):655-658. Epub 2018 Oct 23.

Laboratory of Microbiology, A.O. SS Antonio e Biagio e Cesare Arrigo, Via Venezia 16, 15121 Alessandria, Italy. Electronic address:

Herein we describe a 43 year-old Caucasian female patient with acute myeloid leukemia that developed an unconventional form of invasive Aspergillosis. For therapeutic reasons, a Groshong-type central venous catheter was positioned. Monitoring the patient's clinical conditions, positive values for C-reactive protein and galactomannan were correlated with a probably Aspergillosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11565233183010
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http://dx.doi.org/10.1016/j.mycmed.2018.10.002DOI Listing
December 2018
12 Reads

Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis.

Oxf Med Case Reports 2018 Nov 22;2018(11):omy094. Epub 2018 Oct 22.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan.

An 82-year-old man with a recurrence of pulmonary pleomorphic carcinoma was treated with pembrolizumab. He achieved partial response after three cycles of pembrolizumab. However, he developed febrile neutropenia. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy09
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http://dx.doi.org/10.1093/omcr/omy094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196766PMC
November 2018
9 Reads

Appraising of the Clinical Practice Guidelines Quality in the Non-Pharmacological Management of Chemotherapy-Induced Febrile Neutropenia; A Review

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2701-2707. Epub 2018 Oct 26.

Social Determinant Health Research Center, Faculty of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran. Email: Taleghani@ nm.mui.ac.ir

Background: Febrile neutropenia is a common and serious chemotherapy side effect, is associated with increased mortality, morbidity, and treatment expenditures. Several CPGs (Clinical practice guidelines) have been released for managing chemotherapy-induced febrile neutropenia. The aim of this study is Appraisal of the clinical practice Guidelines quality in the management of chemotherapy-induced febrile neutropenia. Read More

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http://journal.waocp.org/article_69905.html
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291058PMC
October 2018
10 Reads

Invasive Fungal Disease in Children with Acute Leukemia: The Elusive Culprit.

Indian J Pediatr 2018 12 16;85(12):1059-1060. Epub 2018 Oct 16.

Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://link.springer.com/10.1007/s12098-018-2802-1
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http://dx.doi.org/10.1007/s12098-018-2802-1DOI Listing
December 2018
6 Reads
0.920 Impact Factor

Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole.

Indian J Pediatr 2018 Oct 16. Epub 2018 Oct 16.

Department of Pediatric Surgery, Cukurova University Faculty of Medicine, Adana, Turkey.

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http://dx.doi.org/10.1007/s12098-018-2799-5DOI Listing
October 2018
20 Reads

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis.

Front Pharmacol 2018 26;9:1049. Epub 2018 Sep 26.

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.

Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01049
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http://dx.doi.org/10.3389/fphar.2018.01049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169204PMC
September 2018
14 Reads

Implication of antibodies against human leukocyte antigen in simultaneous presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia.

Transfus Apher Sci 2018 Dec 29;57(6):773-776. Epub 2018 Sep 29.

Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, United States.

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal alloimmune neutropenia (NAN) are two rare complications of newborns caused by antibodies against paternal inherited antigens. Human platelet (HPA) and neutrophil antigens (HNA) are the common targets. Human leukocyte antigen (HLA) class I proteins are also expressed on platelets and neutrophils and anti-HLA antibodies have occasionally been implicated in these complications. Read More

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http://dx.doi.org/10.1016/j.transci.2018.09.018DOI Listing
December 2018
4 Reads

Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity?

Authors:
Rashmi R Shah

J Clin Pharm Ther 2019 Feb 11;44(1):129-133. Epub 2018 Oct 11.

Pharmaceutical Consultant, Buckinghamshire, UK.

What Is Known And Objective: Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence.

Comment: Although interethnic differences in drug response are well known, there are no reliable epidemiologic data to support the above claim. Read More

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http://dx.doi.org/10.1111/jcpt.12768DOI Listing
February 2019
20 Reads

Beta-lactam-induced severe neutropaenia: a descriptive study.

Fundam Clin Pharmacol 2018 Oct 5. Epub 2018 Oct 5.

Centre Régional de Pharmacovigilance, Hospices Civils de Lyon, Service Hospitalo-Universitaire de Pharmacotoxicologie, 162 avenue Lacassagne, Lyon, 69424, France.

The objectives of this study were to describe the characteristics and natural history of beta-lactam-induced severe neutropaenia and to evaluate the risk of recurrences after another beta-lactam readministration. Reports of pure agranulocytosis associated with a beta-lactam exposure within the 10 days preceding the neutropaenia were extracted from the French Pharmacovigilance Database over the year 2010. Cases with another evident cause or more likely attributable to another drug were excluded. Read More

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http://doi.wiley.com/10.1111/fcp.12419
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http://dx.doi.org/10.1111/fcp.12419DOI Listing
October 2018
6 Reads

Continuing Clozapine Treatment in Acute Psychosis With Neutropenia.

J Neuropsychiatry Clin Neurosci 2019 4;31(1):95-96. Epub 2018 Oct 4.

From the Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan (P-C L, K-H C); Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan (K-H C); and the Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (K-H C).

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http://dx.doi.org/10.1176/appi.neuropsych.18060139DOI Listing
October 2018
4 Reads

Trends in adverse drug reaction-related hospitalisations over 13 years in New South Wales, Australia.

Intern Med J 2019 Jan;49(1):84-93

Research School of Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.

Background: Adverse drug reactions (ADR) are severe problems in global public health, and result in high mortality and morbidity. Various trends of ADR-related hospitalisations have been studied in many countries, while estimates of the trends in Australia are limited.

Aim: To examine trends in ADR-related hospitalisations in New South Wales (NSW). Read More

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http://doi.wiley.com/10.1111/imj.14134
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http://dx.doi.org/10.1111/imj.14134DOI Listing
January 2019
5 Reads

Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis.

Ann Pharmacother 2018 Oct 3:1060028018805866. Epub 2018 Oct 3.

National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1177/1060028018805866DOI Listing
October 2018
3 Reads

[Host Defense against Bacterial Infection and Bacterial Toxin-induced Impairment of Innate Immunity].

Authors:
Masaya Takehara

Yakugaku Zasshi 2018 ;138(10):1249-1253

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

 Whereas granulopoiesis during Gram-negative bacterial infection is accelerated through activation of toll-like receptor 4 (TLR4), it has not been elucidated whether Gram-positive bacterial infection can stimulate granulopoiesis. Using the well-known TLR2 agonist peptidoglycan (PGN), it was shown that neutrophils in bone marrow and spleen and plasma granulocyte colony-stimulating factor were increased in mice that had received intraperitoneal administration of PGN. Incorporation of bromodeoxyuridine into bone marrow neutrophils increased in mice administered PGN, demonstrating that PGN promotes granulopoiesis. Read More

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http://dx.doi.org/10.1248/yakushi.18-00102DOI Listing
October 2018
5 Reads

The relationship between mortality and microbiological parameters in febrile neutropenic patients with hematological malignancies.

Saudi Med J 2018 Sep;39(9):878-885

Department of Infectious Diseases & Clinical Microbiology, Izmir Bozyaka Training and Research hospital, University of Health Science, Izmir, Turkey. E-mail.

Objectives: To determine effective risk factors on mortality in febrile neutropenic cases with hematologic malignancy. Patients with hematologic diseases are more prone to infections and those are frequent causes of mortality.

Methods: This retrospective study was performed using data of 164 febrile neutropenic cases with hematologic malignancies who were followed up in a hematology clinic of a tertiary health care center between 2011-2015. Read More

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http://dx.doi.org/10.15537/smj.2018.9.22824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201010PMC
September 2018
4 Reads

The change in peripheral blood monocyte count: A predictor to make the management of chemotherapy-induced neutropenia.

J Cancer Res Ther 2018 Sep;14(Supplement):S565-S570

Department of Radiation and Medical Oncology; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, China.

Purpose: The occurrence of neutropenia following chemotherapy makes the management of myelosuppression important. The main objective of this study was to evaluate whether the decrease of peripheral blood monocytes was a potential indicator to predict the occurrence of neutropenia.

Patients And Methods: We retrospectively reviewed the medical records of 103 chemotherapy patients who underwent neutropenia. Read More

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http://dx.doi.org/10.4103/0973-1482.177502DOI Listing
September 2018
2 Reads

Febrile neutropenia (FN) occurrence outside of clinical trials: occurrence and predictive factors in adult patients treated with chemotherapy and an expected moderate FN risk. Rationale and design of a real-world prospective, observational, multinational study.

BMC Cancer 2018 Sep 24;18(1):917. Epub 2018 Sep 24.

Medical Oncology, Institut Jules Bordet, Brussels, Belgium.

Background: Febrile neutropenia (FN) is a common occurrence during chemotherapy. Granulocyte colony-stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSF for patients receiving chemotherapy with FN risk of ≥20% or 10% to 20% with defined risk factors. Read More

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http://dx.doi.org/10.1186/s12885-018-4838-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154917PMC
September 2018
3 Reads

Complementary Treatment with Mistletoe Extracts During Chemotherapy: Safety, Neutropenia, Fever, and Quality of Life Assessed in a Randomized Study.

J Altern Complement Med 2018 Sep/Oct;24(9-10):954-961

2 Clinical Research Dr. Tröger (CRDT) , Freiburg, Germany .

Objectives: Evaluate the safety and clinical response of complementary treatment with European mistletoe extracts during chemotherapy.

Design: Monocentric controlled trial with 95 patients randomized into three groups.

Settings/location: National Cancer Research Center of Serbia. Read More

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http://dx.doi.org/10.1089/acm.2018.0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157372PMC
October 2018
3 Reads

Bloodstream infections in oncology patients at Red Cross War Memorial Children's Hospital, Cape Town, from 2012 to 2014.

Int J Infect Dis 2018 Dec 19;77:40-47. Epub 2018 Sep 19.

Haematology-Oncology Unit, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Objectives: This study was performed to investigate the epidemiology of bloodstream infection (BSI) in oncology patients at Red Cross War Memorial Children's Hospital (RCWMCH), Cape Town, with focus placed on the most common causes, complications, and antimicrobial susceptibilities in BSI.

Methods: A retrospective cross-sectional study was conducted in the Haematology-Oncology Unit of RCWMCH. All positive blood cultures from RCWMCH oncology patients obtained in 2012 to 2014 were retrieved to identify cases of BSI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183452
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http://dx.doi.org/10.1016/j.ijid.2018.09.012DOI Listing
December 2018
10 Reads
2.330 Impact Factor

Relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs: a meta-analysis.

Int J Biol Markers 2018 Sep 21:1724600818792897. Epub 2018 Sep 21.

3 First Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

Although many previous studies have reported the relationship between GSTP1 rs1695 gene polymorphism and myelosuppression induced by platinum-based drugs, the conclusions are not consistent. The aim of the study is to evaluate the association between granulocytopenia and thrombocytopenia induced by platinum-based drugs and GSTP1 rs1695 gene polymorphism by meta-analysis. A literature search was performed using the Pubmed, Embase, CNKI, and Wanfang databases, and the odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the correlation. Read More

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http://dx.doi.org/10.1177/1724600818792897DOI Listing
September 2018
10 Reads

Toxicity and Efficacy of Sequential Chemotherapy in Patients with p-stage I Non-small Cell Lung Cancer that Recurring during Postoperative Tegafur-Uracil Adjuvant Chemotherapy.

Cancer Invest 2018 20;36(8):424-430. Epub 2018 Sep 20.

a Division of Respiratory Disease , Kumamoto Regional Medical Center , Kumamoto , Japan.

It is not clear whether sequential chemotherapy can be performed immediately in patients with p-stage I non-small cell lung cancer recurring during a 2-year period of daily oral administration with tegafur-uracil (UFT) as postoperative adjuvant chemotherapy. Patients receiving chemotherapy within 1 month after the discontinuation of UFT (n = 10) (five cases with aggressive recurrent tumors) had the increased risk of grade 4 neutropenia, but the overall survival was not inferior to that in patients who received chemotherapy beginning more than 1 month (n = 11). We could perform sequential chemotherapy immediately while paying attention to grade 4 neutropenia. Read More

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https://www.tandfonline.com/doi/full/10.1080/07357907.2018.1
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http://dx.doi.org/10.1080/07357907.2018.1515954DOI Listing
November 2018
8 Reads

Efficacy of pegfilgrastim administration in patients with esophageal cancer treated with docetaxel, cisplatin, and 5-fluorouracil.

Pharmazie 2018 10;73(10):613-616

Chemotherapy is among the standard treatments for esophageal cancer. The docetaxel, 5-fluorouracil, and cisplatin (DCF) protocol yields a better response rate than 5-fluorouracil plus cisplatin. However, the incidence of side effects, such as febrile neutropenia and hematologic toxicity, is also significantly high with the DCF protocol. Read More

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http://dx.doi.org/10.1691/ph.2018.8576DOI Listing
October 2018
3 Reads

Cytomegalovirus-associated haemophagocytic lymphohistiocytosis: a rare cause of febrile neutropenia during cancer chemotherapy.

BMJ Case Rep 2018 Sep 14;2018. Epub 2018 Sep 14.

Department of Haematology, Vejle Hospital, Vejle, Denmark.

Febrile neutropenia (FN) is a common complication in patients with cancer during treatment with antineoplastic drugs. The initial cause is usually bacterial, and treatment of FN follows well-defined algorithms. We report a case of a 62-year-old patient with chronic lymphocytic leukaemia (CLL), who developed FN, which was unresponsive to both empirical antibacterial and empirical antifungal therapy. Read More

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http://dx.doi.org/10.1136/bcr-2018-225592DOI Listing
September 2018
3 Reads