26,283 results match your criteria Granulocytopenia


Dabigratan-related acute agranulocytosis.

Blood Transfus 2019 Mar 21;17(2):163-164. Epub 2019 Jan 21.

Department of Hematology and Transfusion Medicine, "Carlo Poma" Hospital, Mantua, Italy.

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http://dx.doi.org/10.2450/2019.0237-18DOI Listing

Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records.

Expert Opin Drug Saf 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Clinical Research Center , National Center for Children's Health, Beijing Children's Hospital, Capital Medical University , Beijing , China.

Objectives: This study aimed to develop a procedure to explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or drug-induced agranulocytosis (DIA) in children using an electronic health records (EHRs) database.

Methods: A two-stage design was presented. First, the suspected drugs to induce DIN or DIA were selected. Read More

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http://dx.doi.org/10.1080/14740338.2019.1604682DOI Listing

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
2 Reads

Invasive fungal consecutive infections in a patient with acute myeloid leukaemia.

Niger J Clin Pract 2019 Apr;22(4):582-584

Department of Infectious Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

A woman with AML who became febrile and neutropenic after chemotherapy. At the first, Aspergillus was isolated from a sinus biopsy. After 4 weeks, while she was taking voriconazole, another episode of fever combined with dry coughs was detected. Read More

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http://dx.doi.org/10.4103/njcp.njcp_359_17DOI Listing
April 2019
2 Reads

Cytomegalovirus Retinitis in Children and Adolescents with Acute Leukemia following allogeneic Hematopoietic Stem Cell Transplantation.

Transpl Infect Dis 2019 Apr 10:e13089. Epub 2019 Apr 10.

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster.

Cytomegalovirus retinitis (CMVR) may occur after allogeneic hematopoietic stem cell transplantation (HSCT). However, little is known about its incidence, strategies for ophthalmic surveillance, and timely implementation of adequate antiviral treatment in pediatric allogeneic HSCT recipients. We provide a retrospective analysis of the epidemiology and clinical features of CMVR in pediatric allogeneic HSCT patients transplanted at our center over a 16-year period. Read More

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http://dx.doi.org/10.1111/tid.13089DOI Listing
April 2019
5 Reads

Multiple cutaneous and mucosal lesions in a patient with cocaine-levamisole-induced vasculopathy syndrome.

Proc (Bayl Univ Med Cent) 2019 Jan 27;32(1):93-95. Epub 2018 Dec 27.

Division of Rheumatology, Department of Internal Medicine, Rush University Medical CenterChicagoIllinois.

Levamisole is an adulterant found in nearly 70% of cocaine in the United States. The concomitant use of levamisole and cocaine leads to a distinct clinical syndrome that typically manifests as agranulocytosis, leukocytoclastic vasculitis, and elevated antineutrophil cytoplasmic antibody (ANCA) levels. Systemic involvement has also been rarely reported with this syndrome. Read More

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http://dx.doi.org/10.1080/08998280.2018.1503478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442875PMC
January 2019
2 Reads

[Comparison of Pegfilgrastim and Filgrastim for the Primary Prophylactic Effect for Preventing Febrile Neutropenia in Patients Undergoing Rituximab with Dose-adjusted EPOCH Chemotherapy].

Yakugaku Zasshi 2019 ;139(4):629-633

Department of Pharmacy, Hiroshima University Hospital.

The combination of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin with rituximab (DA-EPOCH-R) is used for non-Hodgkin lymphoma patients. Febrile neutropenia (FN) is a common complication of treatment with myelo-suppressive chemotherapy, so preventing FN is important for maintaining chemotherapy dosage. Recently, pegfilgrastim has been used as the primary prophylaxis of FN in Japan, but there have been few cases reported using pegfilgrastim for the primary prophylaxis in DA-EPOCH-R. Read More

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http://dx.doi.org/10.1248/yakushi.18-00101DOI Listing
April 2019
1 Read

Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Oral Pathology and Family Dentistry Section, Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background/purpose: Physicians' and dentists' knowledge of levamisole-induced agranulocytosis or pancytopenia remains incomplete. This study aimed to evaluate the treatment effectiveness of levamisole plus prednisolone on oral lichen planus (OLP) patients with emphasis on levamisole-induced hematological changes.

Methods: Ninety patients with erosive OLP were given 120 mg/day new levamisole (Levazol) and 15 mg/day prednisolone for three consecutive days each week. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.007DOI Listing
March 2019
3 Reads

Prescribing trends and safety of clozapine in an older persons mental health population.

Int Psychogeriatr 2019 Mar 21:1-7. Epub 2019 Mar 21.

Psychiatrist of Old Age, Older Persons Health Specialist Service (OPHSS),Canterbury District Health Board,Christchurch,New Zealand.

ABSTRACTObjectives:To provide additional data concerning the safety, effectiveness and local prescribing trends of clozapine in elderly patients.

Design: Retrospective observational case-series analysis.

Setting: Data were collected from the medical files of 167 patients prescribed clozapine. Read More

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http://dx.doi.org/10.1017/S1041610219000255DOI Listing
March 2019
1 Read

Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event.

Cochrane Database Syst Rev 2019 Mar 19;3:CD009031. Epub 2019 Mar 19.

Centro de adiestramiento en Investigación Clínica, Insitiuto Mexicano del Seguro Social, Centro Medico Nacional Siglo XXI, Hospital de Pediatria del CMN SXXI, Avenida Cuauhtemoc #330, Mexico City, Mexico.

Background: People with febrile neutropaenia are usually treated in a hospital setting. Recently, treatment with oral antibiotics has been proven to be as effective as intravenous therapy. However, the efficacy and safety of outpatient treatment have not been fully evaluated. Read More

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http://dx.doi.org/10.1002/14651858.CD009031.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423292PMC
March 2019
1 Read

Efficacy of levofloxacin as an antibacterial prophylaxis for acute leukemia patients receiving intensive chemotherapy: a systematic review and meta-analysis.

Hematology 2019 Dec;24(1):362-368

b Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

Objectives: The incidence of febrile neutropenia (FN) in acute leukemia patients following induction or consolidation chemotherapy is high. Several clinical practice guidelines recommend the use of a fluoroquinolone prophylaxis to prevent bacterial infection in patients being prone to prolonged profound neutropenia.

Methods: This systematic review and meta-analysis aimed to investigate the efficacy and complications of levofloxacin as a prophylaxis for FN patients following chemotherapy for acute leukemia. Read More

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http://dx.doi.org/10.1080/16078454.2019.1589706DOI Listing
December 2019
1 Read
1.189 Impact Factor

Failure of rechallenge clozapine after agranulocytosis: A case report.

Encephale 2019 Mar 13. Epub 2019 Mar 13.

Department of psychiatry and addictology, Paul Brousse hospital, AP-HP, 12, avenue Paul Vaillant Couturier, 94800 Villejuif, France; Faculté de médecine, Paris Sud university, Le Kremlin-Bicetre, 94270 Île-de-France, France; Institut national de la santé et de la recherche médicale U 1178, 91190 Paris, France.

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http://dx.doi.org/10.1016/j.encep.2019.02.003DOI Listing
March 2019
1 Read

Oxacillin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Am J Case Rep 2019 Mar 16;20:345-348. Epub 2019 Mar 16.

Department of Pulmonary and Critical Care, NYU Langone, New York City, NY, USA.

BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic life-threatening reaction comprised of fevers, rash, and leukocytosis with eosinophilia. Though characteristically associated with leukocytosis, there are rare case reports of DRESS-induced agranulocytosis. DRESS is most frequently caused by antiepileptic medications; however, it has very rarely been reported in relation to oxacillin. Read More

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http://dx.doi.org/10.12659/AJCR.913748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434607PMC

A multicenter observational study of the real-world use of docetaxel for metastatic castration-resistant prostate cancer in China.

Asia Pac J Clin Oncol 2019 Mar 15. Epub 2019 Mar 15.

Fudan University Shanghai Cancer Center, Shanghai, China.

Aim: To investigate the use of docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in real-world clinical practice in China.

Methods: This single-arm, prospective, observational study was conducted at 32 study centers in China and included male patients aged ≥18 years with histologically confirmed prostate cancer who received ≥1 dose of docetaxel following failure of hormonal therapy (disease progression with serum testosterone <50 ng/dL). The primary aim was to investigate patterns of docetaxel treatment. Read More

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http://dx.doi.org/10.1111/ajco.13142DOI Listing
March 2019
3 Reads

A meta-analysis of controlled studies comparing the association between clozapine and other antipsychotic medications and the development of neutropenia.

Aust N Z J Psychiatry 2019 Mar 13:4867419833166. Epub 2019 Mar 13.

2 School of Medicine, The University of Queensland, St Lucia, QLD, Australia.

Background:: In most countries, clozapine can only be prescribed with regular monitoring of white blood cell counts because of concerns that clozapine has a stronger association with neutropenia than other antipsychotics. However, this has not been previously demonstrated conclusively with meta-analysis of controlled studies.

Methods:: The aim of this study was to assess the strength of the association between clozapine and neutropenia when compared to other antipsychotic medications by a meta-analysis of controlled studies. Read More

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http://dx.doi.org/10.1177/0004867419833166DOI Listing
March 2019
1 Read

[Association between the time of neutrophils to the lowest and prognosis of patients with esophageal squamous cell carcinoma treated with non-operative therapy].

Zhonghua Zhong Liu Za Zhi 2019 Feb;41(2):124-128

School of Public Health, Fujian Medical University, Fuzhou 350100, China.

To investigate the association between the time of neutrophils to the lowest and prognosis of patients with esophageal squamous cell carcinoma (ESCC) treated with non-operative therapy. The clinical data of 325 non-operative treated ESCC patients were collected in this study. The X-title software was applied to establish optimal threshold of neutrophil reduction to the lowest value. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.02.009DOI Listing
February 2019
1 Read

The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies.

Psychol Med 2019 Mar 12:1-12. Epub 2019 Mar 12.

Unit of Psychiatry,Centre of Translational Medicine, Faculty of Health Sciences, University of Macau,Macao SAR,China.

Background: Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients.

Methods: A literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Read More

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http://dx.doi.org/10.1017/S0033291719000369DOI Listing
March 2019
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Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand.

Asian J Psychiatr 2019 Mar 5;41:13-16. Epub 2019 Mar 5.

Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.03.002DOI Listing

[Leukemia caused by collision with a wild pig?]

Dtsch Med Wochenschr 2019 Mar 5;144(5):335-339. Epub 2019 Mar 5.

Medizinische Klinik 3, Centrum für Integrierte Onkologie (CIO) Köln-Bonn, Universitätsklinikum Bonn.

History:  A 23 years old, previously healthy woman was admitted to our clinic with neutropenic fever to rule out acute leukemia. Upon admission the patient reported that a few days ago the carcass of a pig had fallen on her from above, so that she experienced strong back pain.

Findings And Diagnosis:  The blood count showed thrombocytopenia and marked neutropenia of 0. Read More

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http://dx.doi.org/10.1055/a-0826-2446DOI Listing
March 2019
1 Read

Alcohol abuse and disorder of granulopoiesis.

Pharmacol Ther 2019 Mar 1. Epub 2019 Mar 1.

Department of Integrative Medical Sciences, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, United States of America; Department of Surgery, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, United States of America. Electronic address:

Granulocytes are the major type of phagocytes constituting the front line of innate immune defense against bacterial infection. In adults, granulocytes are derived from hematopoietic stem cells in the bone marrow. Alcohol is the most frequently abused substance in human society. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.03.001DOI Listing
March 2019
2 Reads

Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.

Ann Nutr Metab 2019 27;74(3):200-206. Epub 2019 Feb 27.

College of Medicine and Forensic, Health Science Center, Xi'an Jiao Tong University, Xi'an, China,

Some effective antithyroid drugs (ATDs) have been widely used for patients with Graves' disease (GD) but are associated with ATD-induced agranulocytosis. We selected 29 ATD-induced agranulocytosis patients, 44 ATD-induced neutropenia patients, and 140 GD controls among the Chinese Han population who were recruited at the First Affiliated Hospital of Xi'an Jiao Tong University. We assessed their response to ATDs treatment by performing genotyping for a candidate gene association study of samples from patients receiving treatment. Read More

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http://dx.doi.org/10.1159/000497314DOI Listing
February 2019
2 Reads

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 02;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1814213
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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019
15 Reads

Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence.

Indian J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Pharmacology, TOBB Economics and Technology University Medical School, Söğütözü cad no, 43 06560, Ankara, Turkey.

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http://dx.doi.org/10.1007/s12098-019-02881-zDOI Listing
February 2019
1 Read

Sequencing of anthracyclines and taxanes in neoadjuvant and adjuvant therapy for early breast cancer.

Cochrane Database Syst Rev 2019 02 18;2:CD012873. Epub 2019 Feb 18.

Medical Oncology Department, Concord Repatriation General Hospital, Concord, New South Wales, Australia, 2139.

Background: Anthracyclines and taxanes are chemotherapeutic agents widely used in a sequential regimen in the adjuvant and neoadjuvant treatment of early breast cancer to reduce the risk of cancer recurrence. Standard practice is to administer anthracycline-based chemotherapy followed by a taxane. Anthracyclines tend to be administered first as they were established before taxanes for treatment of early breast cancer. Read More

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http://dx.doi.org/10.1002/14651858.CD012873.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378927PMC
February 2019
8 Reads

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective.

Pharmacogenomics 2019 Mar 15;20(4):279-290. Epub 2019 Feb 15.

MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia. We now know that the genetic etiology of clozapine-associated neutropenia is complex and is likely to involve variants from several genes including HLA-DQB1, HLA-B and SLCO1B3/SLCO1B7. Read More

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http://dx.doi.org/10.2217/pgs-2018-0188DOI Listing
March 2019
1 Read

Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.

Anticancer Res 2019 Feb;39(2):1029-1034

Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.

Aim: This study aimed to clarify the tolerability of a trifluridine/tipiracil combination tablet (TAS-102) in patients with advanced or recurrent colorectal cancer over 75 years of age.

Patients And Methods: Patients were divided into groups under the age of 75 years (n=62), and 75 years and over (n=17). The treatment period with TAS-102 tablet, reasons for discontinuation, adverse events (AEs), and overall survival (OS) were compared between the groups. Read More

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http://dx.doi.org/10.21873/anticanres.13209DOI Listing
February 2019
8 Reads

A rare diagnosis of primary native kidney non-hodgkin's lymphoma after kidney transplantation.

Nephrology (Carlton) 2019 Feb;24(2):272

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR.

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http://dx.doi.org/10.1111/nep.13426DOI Listing
February 2019
1 Read

Comparison of neutropenia profiles in different treatment protocols for acute myeloid leukemia using the D-index.

Int J Hematol 2019 Apr 25;109(4):470-476. Epub 2019 Jan 25.

Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Neutropenia is a major risk factor for opportunistic infections in patients with acute myeloid leukemia (AML) who undergo chemotherapy. In the present study, we retrospectively compared the D-index, which reflects both the depth and duration of neutropenia, between two different chemotherapy regimens for AML. Sixty-seven patients with AML were included: 37 received an induction regimen of daunorubicin (DNR) and cytarabine followed by consolidation therapies consisting of standard-dose cytarabine (SDAC) and other antineoplastic agents; the remaining 30 received idarubicin (IDR) and cytarabine as remission induction therapy followed by high-dose cytarabine (HDAC). Read More

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http://link.springer.com/10.1007/s12185-019-02593-2
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http://dx.doi.org/10.1007/s12185-019-02593-2DOI Listing
April 2019
11 Reads
1.679 Impact Factor

[Perioperative use of metamizole and other nonopioid analgesics in children : Results of a survey].

Anaesthesist 2019 Mar 24;68(3):152-160. Epub 2019 Jan 24.

Klinik für Anästhesiologie und Schmerztherapie, Universitätsklinik Bern, Inselspital, Universität Bern, Freiburgstrasse, 3010, Bern, Schweiz.

Background: Nonopioid analgesics are frequently used for perioperative pain management in children. In many countries, the nonopioid metamizole (dipyrone) is administered as an alternative to paracetamol and traditional NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen and diclofenac; however, concerns over possible life-threatening adverse events (agranulocytosis) have prompted a debate over the use of metamizole.

Objective: To investigate current practice and use of nonopioid analgesics, particularly of metamizole in children younger than 14 years, in the perioperative setting. Read More

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http://dx.doi.org/10.1007/s00101-018-0532-4DOI Listing
March 2019
3 Reads

[Mitoxantrone-cytarabine-etoposide induction therapy in children with acute myeloid leukemia: a single-center study of complications and clinical outcomes].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):24-28

Department of Pediatric Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

Objective: To investigate the complications and clinical outcome of children with acute myeloid leukemia (AML) undergoing mitoxantrone-cytarabine-etoposide (MAE) induction therapy.

Methods: A total of 170 children with AML were given MAE induction therapy, and the complications and remission rate were analyzed after treatment.

Results: The male/female ratio was 1. Read More

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January 2019
11 Reads

Congenital neutropenia and primary immunodeficiency diseases.

Crit Rev Oncol Hematol 2019 Jan 13;133:149-162. Epub 2018 Oct 13.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Neutropenia is a dangerous and potentially fatal condition that renders patients vulnerable to recurrent infections. Its severity is commensurate with the absolute count of neutrophil granulocytes in the circulation. In paediatric patients, neutropenia can have many different aetiologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428173049
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http://dx.doi.org/10.1016/j.critrevonc.2018.10.003DOI Listing
January 2019
12 Reads
4.027 Impact Factor

Neutropenia at the time of subcutaneous port insertion may not be a risk factor for early infectious complications in pediatric oncology patients.

J Pediatr Surg 2019 Jan 5;54(1):145-149. Epub 2018 Oct 5.

Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center and Le Bonheur Children's Hospital, Memphis, TN. Electronic address:

Background: The risk of infection associated with subcutaneous port (SQP) placement in patients with neutropenia remains unclear. We reviewed the rate of early infectious complications (<30 days) following SQP placement in pediatric oncology patients with or without neutropenia [absolute neutrophil count (ANC) <500/mm].

Methods: Baseline characteristics and infectious complications were compared between groups using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347387PMC
January 2019
5 Reads

Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment.

BMJ Case Rep 2019 Jan 18;12(1). Epub 2019 Jan 18.

Monter Cancer Center-Division of Hematology Oncology, Northwell Health, Lake Success, New York, USA.

A 26-year-old man with history of schizophrenia was admitted for neutropaenia. He was started on clozapine 3 months prior to admission. As a result he had weekly monitoring of his blood counts and on day of admission was noted to have an absolute neutrophil count (ANC) of 450 cells/μL. Read More

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http://dx.doi.org/10.1136/bcr-2018-226016DOI Listing
January 2019
7 Reads

Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.

Biochem Pharmacol 2019 May 14;163:345-356. Epub 2019 Jan 14.

Division of Clinical Pharmacology & Toxicology, University Hospital, Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Centre of Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address:

Metamizole is an analgesic and antipyretic, but can cause neutropenia and agranulocytosis. We investigated the toxicity of the metabolites N-methyl-4-aminoantipyrine (MAA), 4-aminoantipyrine (AA), N-formyl-4-aminoantipyrine (FAA) and N-acetyl-4-aminoantipyrine (AAA) on neutrophil granulocytes and on HL60 cells (granulocyte precursor cell line). MAA, FAA, AA, and AAA (up to 100 µM) alone were not toxic for HL60 cells or granulocytes. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.01.011DOI Listing
May 2019
4 Reads

Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study.

Thyroid 2019 Feb;29(2):193-201

3 Department of Community Medicine and Epidemiology, Clalit Health Services, Haifa, Israel.

Background: Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. Read More

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http://dx.doi.org/10.1089/thy.2018.0274DOI Listing
February 2019
2 Reads

Evaluation of a Carbapenem-Saving Strategy Using Empirical Combination Regimen of Piperacillin-Tazobactam and Amikacin in Hemato-Oncology Patients.

J Korean Med Sci 2019 Jan 4;34(2):e17. Epub 2019 Jan 4.

Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We implemented a carbapenem-saving strategy in hemato-oncology patients from 2013, using an empirical combination of piperacillin-tazobactam and amikacin for high-risk hemato-oncology patients with febrile neutropenia, who remain hemodynamically unstable > 72 hours despite initial cefepime treatment. All-cause mortality was not different between the two periods (6.54 and 6. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327090PMC
January 2019
2 Reads

Acute agranulocytosis when switching from risperidone to paliperidone.

Aust N Z J Psychiatry 2019 Jan 14:4867418821441. Epub 2019 Jan 14.

Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1177/0004867418821441DOI Listing
January 2019
8 Reads

Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency.

Proc Natl Acad Sci U S A 2019 01 9;116(4):1241-1250. Epub 2019 Jan 9.

Walloon Excellence in Lifesciences and Biotechnology, B-1200 Brussels, Belgium;

Neutropenia represents an important problem in patients with genetic deficiency in either the glucose-6-phosphate transporter of the endoplasmic reticulum (G6PT/SLC37A4) or G6PC3, an endoplasmic reticulum phosphatase homologous to glucose-6-phosphatase. While affected granulocytes show reduced glucose utilization, the underlying mechanism is unknown and causal therapies are lacking. Using a combination of enzymological, cell-culture, and in vivo approaches, we demonstrate that G6PT and G6PC3 collaborate to destroy 1,5-anhydroglucitol-6-phosphate (1,5AG6P), a close structural analog of glucose-6-phosphate and an inhibitor of low- hexokinases, which catalyze the first step in glycolysis in most tissues. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1816143116
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http://dx.doi.org/10.1073/pnas.1816143116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347702PMC
January 2019
10 Reads

Real world evidence on gemcitabine and nab-paclitaxel combination chemotherapy in advanced pancreatic cancer.

BMC Cancer 2019 Jan 8;19(1):40. Epub 2019 Jan 8.

Division of Oncology, Department of clinical and experimental medicine, Faculty of medicine and health sciences, Linköping University, 58183, Linköping, Sweden.

Background: In the recent phase III trial MPACT the combination of gemcitabine and nab-paclitaxel (Gem/NabP) showed increased overall survival compared to gemcitabine alone in the treatment of advanced pancreatic ductal adenocarcinoma (aPDA). Until now there has been limited information on the clinical benefit and toxicity of the combination regimen in a real world setting. In addition the value for patients with locally advanced rather than metastatic aPDA has been unclear, since the former category of patients was not included in the MPACT trial. Read More

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http://dx.doi.org/10.1186/s12885-018-5244-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325739PMC
January 2019
2 Reads

Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.

PLoS Comput Biol 2019 01 7;15(1):e1006664. Epub 2019 Jan 7.

Systems Engineering Group, Silesian University of Technology, Gliwice, Poland.

Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passenger (neutral or mildly deleterious) mutations. We focus on a real-world leukemia model evolving on the background of a germline mutation. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336352PMC
January 2019
6 Reads

Safety of Y-ibritumomab Tiuxetan Treatment for Japanese Patients in Real-world Clinical Practice.

Yakugaku Zasshi 2019 ;139(1):131-134

Department of Pharmaceutical Services, Hiroshima University Hospital.

When undergoing Y-ibritumomab tiuxetan (90Y-IT) treatment, patients are discharged from hospital soon after initiation of treatment and followed up as outpatients. Thus it is important to apprise patients of the safety information regarding 90Y-IT treatment. However, studies investigating the safety of 90Y-IT in real-world clinical practice are lacking. Read More

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http://dx.doi.org/10.1248/yakushi.18-00112DOI Listing
April 2019
1 Read

Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer.

Cochrane Database Syst Rev 2019 Jan 3;1:CD012184. Epub 2019 Jan 3.

Division of Infectious Diseases, Rambam Health Care Campus, Ha-aliya 8 St, Haifa, Israel, 33705.

Background: People with cancer with febrile neutropenia are at risk of severe infections and mortality and are thus treated empirically with broad-spectrum antibiotic therapy. However, the recommended duration of antibiotic therapy differs across guidelines.

Objectives: To assess the safety of protocol-guided discontinuation of antibiotics regardless of neutrophil count, compared to continuation of antibiotics until neutropenia resolution in people with cancer with fever and neutropenia, in terms of mortality and morbidity. Read More

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http://dx.doi.org/10.1002/14651858.CD012184.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353178PMC
January 2019
4 Reads

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies.

AAPS PharmSciTech 2019 Jan 2;20(1):22. Epub 2019 Jan 2.

Department of Pharmaceutics, Sinhgad Institute of Pharmacy, Sinhgad Technical Education Society, Narhe, Pune, MS, 411041, India.

Potential risk of agranulocytosis is one of the drug-induced adverse effects of the second-generation antipsychotic agents. The present investigation aimed to formulate and investigate olanzapine (OLZ)-loaded nanostructured lipid carriers (OLZ-NLCs) via intranasal (i.n. Read More

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http://dx.doi.org/10.1208/s12249-018-1213-yDOI Listing
January 2019
10 Reads

5-HT deletion protects against Clozapine-induced hyperglycemia.

J Pharmacol Sci 2019 Feb 18;139(2):133-135. Epub 2018 Dec 18.

National Centre for Biological Sciences, TIFR, GKVK Campus, Bellary Road, Bengaluru, India; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. Electronic address:

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.015DOI Listing
February 2019
3 Reads

A qualitative exploration of clozapine prescribing and monitoring practices in the Arabian Gulf countries.

Asian J Psychiatr 2019 Jan 21;39:93-97. Epub 2018 Dec 21.

Hamad Medical Corporation, Mental Health Hospital, Doha, Qatar.

Clozapine is considered as the first line antipsychotic for treatment resistant schizophrenia (TRS). Worldwide reports indicate an overall underutilization of clozapine in patients experiencing TRS. This study aims to understand the prescribing practices, monitoring strategies and barriers to the use of clozapine in the Arabian Gulf (AG) region. Read More

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http://dx.doi.org/10.1016/j.ajp.2018.12.011DOI Listing
January 2019
2 Reads

Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report.

BMC Infect Dis 2018 Dec 29;18(1):706. Epub 2018 Dec 29.

Department of Emergency Internal Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, People's Republic of China.

Background: Blood infection with Candida glabrata often occurs in during severe acute pancreatitis (SAP). It complicate severe agranulocytosis has not been reported.

Case Presentation: We present a case where a SAP patient presenting with a sudden hyperpyrexia was treated for 19 days. Read More

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http://dx.doi.org/10.1186/s12879-018-3623-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310945PMC
December 2018
8 Reads
2.613 Impact Factor

Intravenously administered cloxacillin-induced neutropenia with eosinophilia in a patient with infective endocarditis: a case report.

J Med Case Rep 2018 Dec 29;12(1):384. Epub 2018 Dec 29.

Teaching Hospital Kurunegala, Kurunegala, Sri Lanka.

Background: Bacteremia following Staphylococcus aureus is a serious clinical condition which is often associated with distant metastatic infections. One of the most dreaded complications of Staphylococcus aureus bacteremia is infective endocarditis. Cloxacillin is a common antibiotic prescribed for suspected staphylococcal infections and confirmed methicillin-sensitive Staphylococcus aureus infections. Read More

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http://dx.doi.org/10.1186/s13256-018-1933-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310943PMC
December 2018
3 Reads

Levamisole-induced vasculitis.

JAAPA 2019 Jan;32(1):23-27

At the John S. Dunn Burn Center at Memorial Hermann Hospital, part of the University of Texas Health Science Center at Houston, Tex., Tonya C. George is an assistant professor of surgery, Daniel J. Freet is an assistant professor, James M. Cross is a professor of surgery, and Todd F. Huzar is an associate professor of surgery. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Levamisole is a veterinary antihelminthic, chemotherapeutic agent, and immunomodulator that also is used as an adulterant and cutting agent in cocaine distribution. This drug may potentiate the sympathomimetic actions of cocaine and can cause neutropenia, agranulocytosis, purpuric retiform lesions, and skin necrosis. This article describes two cases of suspected levamisole-induced vasculitis. Read More

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http://dx.doi.org/10.1097/01.JAA.0000547746.08181.f7DOI Listing
January 2019
2 Reads

A Qualitative Analysis of the Impact of Carboplatin AUC 10 on Physical, Work Functioning and Bone Marrow Toxicity Among Seminoma Patients - A Single-centre Experience.

In Vivo 2019 Jan-Feb;33(1):233-237

Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, U.K.

Background: Single-agent carboplatin at area under the curve 10 (AUC10) is an effective treatment for metastatic seminoma. As far as we are aware of, there have been no studies reporting its effects on short-term quality of life. The objective was to study the efficacy, safety and tolerability, using health-related quality of life, of carboplatin AUC10 chemotherapy in patients with metastatic seminoma. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11465
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http://dx.doi.org/10.21873/invivo.11465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364087PMC
April 2019
19 Reads

Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report.

Transplant Proc 2018 Dec 18;50(10):3925-3927. Epub 2018 Apr 18.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

Background: Azathioprine (AZA) is the drug recommended for the continuation of immunosuppressive treatment after renal transplant in women during pregnancy.

Case Report: A 37-year-old Japanese female developed agranulocytosis and severe alopecia after initiation of AZA (50 mg), used as an alternative to mycophenolate mofetil (MMF, 1000 mg) therapy in anticipation of a planned pregnancy. Within 4 days of the initiation of AZA therapy, the patient developed a high fever, leucopenia, and cranial alopecia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.039DOI Listing
December 2018
2 Reads