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Endocrine 2020 Jul 1. Epub 2020 Jul 1.

Departments of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

Posterior pituitary tumors are rare nonneuroendocrine neoplasms originating in the neurohypophysis that lack hormonal secretory capacity. Surprisingly, these tumors are relatively frequently associated with adenohypophyseal syndromes of hormonal hypersecretion such as Cushing's disease and acromegaly. Fifteen cases of posterior pituitary tumor associated with hypercortisolism have been reported to date, 13 of them were pituicytomas (Pi) and 2 were granular cell tumors (GCT). Read More

Sisli Etfal Hastan Tip Bul 2018 1;52(2):129-134. Epub 2018 Jun 1.

Department of Histology and Embryology, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.

Objectives: The currently widely used technological devices give rise to electromagnetic fields (EMFs) at various frequencies. Recent studies have reported that EMFs damage the central nervous system. The cerebellum is of considerable importance to human life due to its involvement in motor control, language, and cognitive-sensory functions. Read More

J Pediatr Adolesc Gynecol 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology department, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine,University of Science and Technology of China, Hefei 230001,Anhui ,P.R.

Background: Granular cell tumors (GCTs) are usually benign and occur primarily in the trunk and head. Vaginal tumors are rare, particularly in children.

Case: A 9-year-old girl was admitted with irregular vaginal bleeding for 1 year. Read More

Cureus 2020 May 26;12(5):e8287. Epub 2020 May 26.

Hematology/Oncology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Malignant granular cell tumors (MGCTs) are rare and aggressive variants of granular cell tumors. They usually involve the head and neck region, skin and soft tissues. There are no standard therapeutic guidelines for management; however, surgical resection, whenever feasible, is considered to be first line. Read More

Front Cell Neurosci 2020 3;14:142. Epub 2020 Jun 3.

Physiology Department, Universidade Federal de São Paulo, São Paulo, Brazil.

Inflammatory processes occurring in the perinatal period may affect different brain regions, resulting in neurologic sequelae. Injection of lipopolysaccharide (LPS) at different neurodevelopmental stages produces long-term consequences in several brain structures, but there is scarce evidence regarding alterations in the cerebellum. The aim of this study was to evaluate the long-term consequences on the cerebellum of a systemic inflammatory process induced by neonatal LPS injection. Read More

Front Neurosci 2020 11;14:644. Epub 2020 Jun 11.

Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto "Giannina Gaslini", Genoa, Italy.

Mutations in the gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans. The encoded Wwox protein is a WW domain-containing oxidoreductase that participates in crucial biological processes including tumor suppression, cell growth/differentiation and regulation of steroid metabolism, while its role in neural development is less understood. We analyzed the exomes of a family affected with multiple pre- and postnatal anomalies, including cerebellar vermis hypoplasia, severe neurodevelopmental impairment and refractory epilepsy, and identified a segregating homozygous mutation leading to a premature stop codon. Read More

Clin Pract 2020 May 19;10(1):1255. Epub 2020 May 19.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

Ameloblastoma is the only odontogenic tumor that displays diversified histomorphological features with subtypes like follicular, plexiform, acanthomatous, granular cell, clear cell, desmoplastic etc. In this paper we presented an extremely unusual presentation of ameloblastoma, which is characterized by desmolysis or acantholysis of stellate reticulum-like cells caused due to keratinocyte dissociation. A 35-year-old male patient presented with a painless hard 3×3 cm swelling in the mandibular right posterior region in the past 4-5 months. Read More

Indian J Surg Oncol 2020 Jun 26;11(2):321-324. Epub 2020 Mar 26.

Department of Surgery, ESIC Medical College, Faridabad, Haryana India.

Granular cell tumor (GCT) also known as Abrikossoff's tumor is an uncommon soft tissue tumor of neurogenic origin. GCT of the breast accounts for < 0.1% of breast tumors and 6% of all reported cases of granular cell tumor. Read More

Int J Surg Pathol 2020 Jun 8:1066896920928586. Epub 2020 Jun 8.

Department and Chair of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.

The disease entity of acquired cystic disease-associated renal cell carcinoma (ACD-RCC) has been recently incorporated into the international renal tumor classification. We performed a clinicopathologic study of a patient with bilateral and multifocal ACD-RCCs. The patient received long-term hemodialysis in the end-stage renal disease caused by systemic lupus erythematous. Read More

Dig Endosc 2020 Jun 8. Epub 2020 Jun 8.

Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

The esophageal granular cell tumor (GCT) is rare, often benign tumor originating in the Schwann cells of the nerve sheath. GCT showing growth in size should be resected because of malignant potential. Underwater endoscopic mucosal resection (UW-EMR), which was proposed first for the resection of colorectal neoplasm, enables us to lift and float away the mucosal or submucosal tumor from the muscularis propria without submucosal injection. Read More

Proteomics 2020 Jun 8:e1900359. Epub 2020 Jun 8.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) initiative has generated extensive multi-omics data resources of deep proteogenomic profiles for multiple cancer types. To enable the broader community of biological and medical researchers to intuitively query, explore, and download data and analysis results from various CPTAC projects, we built a prototype user-friendly web application called "ProTrack" with the CPTAC clear cell renal cell carcinoma (ccRCC) data set (http://ccrcc.cptac-data-view. Read More

Surg Neurol Int 2020 9;11:101. Epub 2020 May 9.

Departments of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan.

Background: Granular cell tumor (GCT) of the sellar region is a rare tumor of the sellar and suprasellar regions that originate from the neurohypophysis. This tumor is very difficult to differentiate from other pituitary neoplasms, such as pituitary adenoma, pituicytoma, and spindle cell oncocytoma. We report a rare case of GCT arising from the posterior pituitary of the sellar region and suggest a useful indicator for accurate diagnosis and pitfalls for surgical procedures. Read More

JAAD Case Rep 2020 Jun 4;6(6):546-548. Epub 2020 May 4.

Rush University Medical Center, Chicago, Illinois.

Dig Dis Sci 2020 May 30. Epub 2020 May 30.

Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: Esophageal granular cell tumors (GCTs) are rare tumors. Differences in reports on the clinical features of GCTs in the esophagus and some controversies about the diagnostic strategy for esophageal GCTs exist.

Objectives: We aimed to investigate the clinical features and diagnosis of esophageal GCTs. Read More

Clin Imaging 2020 May 3;66:111-120. Epub 2020 May 3.

Department of Radiology, St Louis University School of Medicine, United States of America. Electronic address:

Breast malignancy is the second most common cause of cancer death in women. However, less common breast masses can mimic carcinoma and can pose diagnostic challenges. This case-based review describes a spectrum of rare breast neoplastic and non-neoplastic masses ranging from malignant to benign entities. Read More

Dis Esophagus 2020 May 25. Epub 2020 May 25.

Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Given their malignant potential, resection of esophageal granular cell tumors (GCTs) is often undertaken, yet the optimal technique is unknown. We present a large series of dedicated endoscopic resection using band ligation (EMR-B) of esophageal GCTs. Patients diagnosed with esophageal GCTs between 2002 and 2019 were identified using a prospectively collected pathology database. Read More

Hum Pathol 2020 May 20;102:7-12. Epub 2020 May 20.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287 USA; Departments of Urology and Oncology, Johns Hopkins University School of Medicine, Baltimore, 21231 MD, USA. Electronic address:

The grading and prognosis of prostatic adenocarcinoma with Paneth cell-like differentiation (PanEC) is controversial with limited available data. We identified 80 cases, not previously published, of PanEC first identified on biopsy (n = 69), transurethral resection of the prostate (n = 1), and radical prostatectomy (RP) (n = 10). Of 69 biopsies, 22 did not have a grade assigned. Read More

World Neurosurg 2020 May 11;140:60-62. Epub 2020 May 11.

Department of Neurosurgery, AZ Delta, Roeselare, Belgium.

Granular cell tumors of the pituitary gland are rare, slow-growing lesions arising from the neurohypophysis or pituitary stalk. We describe an extremely rare presentation of a pituitary granular cell tumor mimicking an anterior communicating artery aneurysmal rupture with ventricular hemorrhage. The patient was admitted in a comatose state and underwent urgent bilateral external ventricular drainage. Read More

Int J Surg Pathol 2020 May 13:1066896920918289. Epub 2020 May 13.

Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China.

Papillary renal neoplasm with reverse polarity is a form of recently described tumor. These tumors are defined by GATA3 positivity, negative vimentin staining, and the presence of both papillary structures and a layer of eosinophilic cells with apical nuclei and a granular cytoplasm. In the present report, we review 7 cases of papillary renal neoplasm with reverse polarity that were GATA3+ and vimentin-, consistent with past reports. Read More

Gastrointest Tumors 2020 Apr 18;7(1-2):41-49. Epub 2019 Dec 18.

Department of Radiology, University of Florida Health, Jacksonville, Florida, USA.

Background: Granular cell tumors (GCTs) or Abrikossoff's tumors are rare neoplasms known to originate from Schwann cells in the peripheral nervous system. These lesions are usually benign; malignancy only occurs in 1-2% of cases. Surgical resection is the traditional treatment method for GCTs, but it poses several risks and disadvantages related to the surgical incompatibility of the patient, the extended recovery time, and the chance of relapse. Read More

Case Rep Gastrointest Med 2020 13;2020:8563718. Epub 2020 Jan 13.

Green Cross Reference Laboratory, Yongin, Republic of Korea.

We report a very rare case of granular cell tumor with a center ulcer of the rectum, which was detected in a 47-year-old man during screening colonoscopy. It is difficult to distinguish granular cell tumor from other subepithelial tumors. However, our case had a center ulcer unlike previous cases. Read More

J Nanosci Nanotechnol 2020 Oct;20(10):6040-6046

Department of Biochemistry, Changzhi Medical College, Changzhi 046000, Shanxi, PR China.

To investigate the anti-proliferative effect of flavonoid nanoparticles on the human ovarian cancer cell line SKOV3. Ten nude mice were intraperitoneally inoculated with the human ovarian cancer SKOV3 cell mixture. The treatment group received tail vein injections with 1. Read More

Zhongguo Gu Shang 2020 04;33(4):352-5

Department of Bone and Joint, the First Bethune Hospital of Jilin University, Changchun 130021, Jilin, China.

Radiol Bras 2020 Mar-Apr;53(2):105-111

Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, Portugal.

Objective: To review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins.

Materials And Methods: We reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018.

Results: All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). Read More

Adv Mater 2020 Jun 21;32(22):e2000020. Epub 2020 Apr 21.

School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.

The formation of an immunological synapse (IS) on recognition of a cancer cell is the main mechanism underlying the natural killer (NK)-cell-mediated killing of tumor cells. Herein, an integrative strategy for cancer therapy against solid tumors is reported, in which alterations in the cleft of IS, following the secretion of acidic granular content, are utilized as a trigger for the delivery of chemotherapeutic drugs. NK cells are decorated with the IS-environment-responsive micellar system to ensure the release of the payload when they attack cancer cells. Read More

World Neurosurg 2020 Apr 10;139:136-141. Epub 2020 Apr 10.

Department of Neurosurgery, Medstar Georgetown University Hospital, Washington, DC, USA.

Background: Granular cell tumors (GCT) are rare soft tissue neoplasms with a nerve sheath origin, most often found in female adult populations. When these tumors arise in the central nervous system, they most commonly appear intradurally in the thoracic or lumbar spine. GCT malignancy rates vary and recurrence rates can be relatively high, thereby necessitating complete resection. Read More

Pathol Int 2020 Jun 5;70(6):364-369. Epub 2020 Apr 5.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

A 36-year-old man was admitted to hospital for a right thyroid nodule incidentally discovered on a chest computed tomography scan for a rib fracture. He had no history of radiation to the head and neck, no known family history of endocrine disease, and no medical or surgical history. A 17 × 10 mm, well-demarcated, multinodular, whitish nodule with neither necrosis nor hemorrhage was found in the right thyroid. Read More

Head Neck Pathol 2020 Apr 2. Epub 2020 Apr 2.

University of Miami Hospital, Miller School of Medicine, 1400 NW 12th Avenue, Room 4078, Miami, FL, 33136, USA.

Granular cell tumors (GCT) are rare soft tissue tumors that involve the head and neck in 50% of patients. Two distinct variants of GCT, one benign (bGCT) and the other malignant (mGCT), involving the hypopharynx, a subsite of the larynx, are presented here. The clinical presentations, radiographic features, pathologic diagnosis in these two variants of GCT are discussed. Read More

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S101-S105. Epub 2020 Feb 28.

Department of Experimental and Clinical Medicine, Maxillo-Facial Unit, Magna Graecia University, Catanzaro, Italy.

Abrikossoff 's tumor, also called granular cell tumor (GCT), is a rare benign neoplasm of the soft tissues. In almost 70% of the cases, it occurs in the head-and-neck region (especially in the tongue), even though it may present in every other part of the body. This neoplasm has a benign behavior usually, but there have been described a malignant transformation in 2%-3% of the cases. Read More

J Vet Diagn Invest 2020 May 19;32(3):440-443. Epub 2020 Mar 19.

Department of Veterinary Diagnostic and Production Animal Medicine (Rahe); College of Veterinary Medicine, Iowa State University, Ames, IA.

Chondrosarcomas are common tumors of the canine appendicular and axial skeleton; however, extraskeletal chondrosarcomas are very rare. Herein we report a case of extraskeletal chondrosarcoma in the tongue of a dog. Histologically, glossal skeletal muscle was infiltrated and effaced by islands of cartilage and streams of spindle-shaped cells. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Mar;49(3):234-238

Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

To analyze the expression of SMARCE1 in clear cell meningioma (CCM), and evaluate the role of SMARCE1 in the differential diagnosis in morphologically similar diseases. Thirteen samples/11 cases of CCMs were collected from the First Affiliated Hospital of Fujian Medical University, Shandong Provincial Hospital, Xuanwu Hospital of Capital Medical University and Thaihe Hospital of Hubei Province from January 2000 to December 2018, as well as 17 cases of meningiomas with clear-cell-like morphology, 782 cases of other types of meningiomas and other intracranial tumors with clear-like morphology. A tissue microarray was made using these cases, on which immunohistochemical/histochemical staining of SMARCE1, SSTR2, EMA, Ki-67, p53, PAS and D-PAS were performed. Read More

Diagn Cytopathol 2020 Jun 18;48(6):576-580. Epub 2020 Mar 18.

Department of Pathology, NYU Langone Health, New York, New York, USA.

Extracardiac rhabdomyoma is an uncommon benign striated muscle tumor with a predilection for the head and neck region. However, it is extremely rare for extracardiac rhabdomyoma to present as a thyroid nodule. We report a case of rhabdomyoma diagnosed by thyroid fine-needle aspiration (FNA) in a patient with Birt-Hogg-Dubé (BHD) syndrome. Read More

Diagn Cytopathol 2020 Jun 14;48(6):571-575. Epub 2020 Mar 14.

Department of Hospital Pathology, Uijeongbu St. Mary's Hospital, Seoul, The Catholic University of Korea, Uijeongbu, Republic of Korea.

Histiocytic sarcoma (HS) is a comparatively rare hematolymphoid neoplasm. Differential diagnosis of this entity has generally been proven to be so difficult that extensive immunohistochemical staining is required to confirm its presence. We herein present a case of HS manifesting as a retroperitoneal mass in which imprint cytology (IC) contributed to the diagnosis. Read More

J Microsc Ultrastruct 2020 Jan-Mar;8(1):1-6. Epub 2019 Nov 8.

Department of Anatomic Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia.

Mesenchymal tumors of the thyroid are extremely rare. Only few isolated cases of primary thyroid granular cell tumor (GrCT) have been reported. The anatomic location of this lesion plays an important role in the differential diagnosis. Read More

Vet Med Int 2020 21;2020:5691974. Epub 2020 Feb 21.

Al-Muthanna Veterinary Hospital, Al-Muthanna Governorate, Iraq.

The papilloma viruses are constituted of double-stranded DNA and are a more common lesion in ruminant's skin in Iraq. The p53 tumor suppressor protein reveals an essential role in cell cycle control. This study intends to investigate the clinical, histopathological, and immunohistochemical features of cutaneous papilloma in ruminants in Iraq. Read More

Front Oncol 2020 18;10:152. Epub 2020 Feb 18.

Hematology and Clinical Immunology Section, Department of Medicine (DIMED), Padova University School of Medicine, Padova, Italy.

Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic lymphocytes, usually presenting with cytopenias and yet lacking a specific therapy. The disease is heterogeneous, including different subsets of patients distinguished by LGL immunophenotype (CD8+ Tαβ, CD4+ Tαβ, Tγδ, NK) and the clinical course of the disease (indolent/symptomatic/aggressive). Even if the etiology of LGLL remains elusive, evidence is accumulating on the genetic landscape driving and/or sustaining chronic LGL proliferations. Read More

Tissue Eng Regen Med 2020 Apr 29;17(2):141-153. Epub 2020 Feb 29.

Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, 682041, India.

Background: Extracellular trap formation (ETosis) by various blood cells has been reported. This trap contains DNA, histones and granular proteins which can elicit an innate immune response by entrapping microorganisms. The trap thus formed has been reported to have an involvement in various pathogenic conditions as well. Read More

Surg Case Rep 2020 Feb 27;6(1):44. Epub 2020 Feb 27.

Department of Surgery, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Background: Granular cell tumors (GCT) in the gastrointestinal tract are rare. Herein, we describe a case of a gastric GCT diagnosed preoperatively by endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) and successfully resected by single-incision laparoscopic surgery (SILS).

Case Presentation: A 46-year-old Japanese woman had a tumor located in the angle of the stomach that was approximately 1. Read More

Turk Neurosurg 2020 ;30(2):237-243

Hitit University School of Medicine, Department of Anesthesiology and Reanimation, Çorum, Turkey.

Aim: To examine the effect of sevoflurane, a halogenated anesthetic used in clinical applications, on oxidative stress and inflammation after an acute traumatic brain injury (TBI) in rats.

Material And Methods: Thirty male Spragueâ€"Dawley rats were divided into three groups: control (Group 1), trauma (Group 2), and trauma+sevoflurane (Group 3). A diffuse TBI model was created for Groups 2 and 3. Read More

Pathol Res Pract 2020 Apr 12;216(4):152865. Epub 2020 Feb 12.

Department of Pathology, North Hospital, University Hospital of St-Etienne, France.

Background: Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature.

Material And Methods: 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration. Read More

Clin Rev Allergy Immunol 2020 Jun;58(3):377-387

Respiratory Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

Mast cells (MCs) are granular cells of the innate immune system which develop from CD34/CD117 progenitors and play a role in orchestrating adaptive immune responses. They have a well-known role in allergic reactions following immunoglobulin (Ig)E-mediated activation of the cell-surface expressed IgE high-affinity receptor (FcεRI). MCs can also respond to various other stimuli due to the expression of a variety of receptors including toll-like receptors (TLRs), immunoglobulin (IgG) receptors (FcγR), complement receptors such as C5a (CD88) expressed by skin MCs, neuropeptides receptors including nerve growth factor receptor, (NGFR), cytokines receptors such as (IL)-1R and IL-3R, and chemokines receptors including CCR-1 and CCR-3. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Feb;23(2):193-195

Isr Med Assoc J 2020 02;22(2):125-126

Department of Gastroenterology and Hepatology, Nazareth Hospital EMMS, Nazareth, affiliated with Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.

Respir Med Case Rep 2020 22;29:101002. Epub 2020 Jan 22.

Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Malignant pulmonary granular cell tumor (GCT) is extremely rare and difficult to distinguish from benign GCT. Most GCTs are neural-type and express S-100. However, a small subset of tumors sub-classified as the non-neural type do not express S-100. Read More

Top Magn Reson Imaging 2020 Feb;29(1):1-16

DASA Company, São Paulo, Brazil.

Magnetic resonance imaging (MRI) has been increasingly used in the detection, localization, and staging of prostate cancer. Because of its excellent soft tissue contrast and multiplane imaging, it can be also very useful in the evaluation of benign prostate diseases. Prostatic benign disorders have a high prevalence, vastly represented by benign prostatic hyperplasia and prostatitis. Read More

Acta Neuropathol Commun 2020 01 30;8(1). Epub 2020 Jan 30.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 70101, Taiwan.

Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric patients from consanguineous families, including microcephaly, cerebellar ataxia with epilepsy, mental retardation, retinal degeneration, developmental delay and early death. Here, we report that targeted disruption of Wwox gene in mice causes neurodevelopmental disorders, encompassing abnormal neuronal differentiation and migration in the brain. Read More

Open Vet J 2019 10 29;9(3):246-252. Epub 2019 Aug 29.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.

Background: Cerebellar cortical degeneration (CCD) is the premature death of cerebellar neurons of heterogeneous etiology that is uncommonly observed as a neurological complication of certain neoplasia.

Case Description: Here, we report an 8-month-old male domestic cat with altered consciousness, symmetric ataxia, hypermetric gait, vertical positional nystagmus, mydriasis, strabismus, intention tremor of the head, and increased patellar reflexes. Neuroanatomical diagnosis suggested a multifocal brain dysfunction (cerebellar and cerebral). Read More

Case Rep Oncol Med 2020 3;2020:3787250. Epub 2020 Jan 3.

Department of Neurological Critical Care Medicine, AtlantiCare Regional Medical Center, 1925 Pacific Avenue, Atlantic City, NJ, USA.

Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures. The category of intracranial germ cell tumors is divided into pure germ cell tumors (GCTs) versus nongerminomatous germ cell tumors (NGGCTs). They are usually present in the second decade of life with a male preponderance. Read More

Am J Dermatopathol 2020 Jan 21. Epub 2020 Jan 21.

Departments of Dermatology, and.

Hybrid peripheral nerve sheath tumors (PNSTs) are rare benign composite neoplasms demonstrating features of multiple endogenous nerve sheath cell types. Hybrid PNSTs with granular cell components are exceedingly rare. Only a handful number of hybrid PNSTs composed of granular cell tumor and perineurioma have been described to date. Read More