Am J Dermatopathol 2021 Mar 9. Epub 2021 Mar 9.
Department of Pathology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; Department of Pathology, Stanford University School of Medicine, Stanford, CA; Department of Dermatology, Stanford University School of Medicine, Stanford, CA; Department of Pathology, Veterans Affairs Central California Health Care System, Fresno, CA; and Cytogenetics Laboratory, Department of Pathology, Stanford Health Care, Palo Alto, CA.
Abstract: Atypical fibroxanthoma (AFX) is a neoplasm that most commonly occurs on sun-damaged skin of the head and neck in elderly patients and that usually exhibits indolent clinical behavior with complete excision. The granular cell variant of AFX demonstrates overlapping histopathologic features with dermal non-neural granular cell tumor (NNGCT), which typically arises on the extremities of young to middle aged adults with rare reports of regional metastasis. A subset of NNGCT harbors ALK rearrangements and expresses ALK by immunohistochemistry. Read More