Search Our Scientific Publications & Authors

Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221109646

Department of Rehabilitation, 556508The Affiliated Hospital of Southwest Medical University, Luzhou, China.

The study aims to detect the expression of Na/taurocholate cotransporter polypeptide in hilar cholangiocarcinoma of rat model, to provide a new therapeutic target for gene therapy of hilar cholangiocarcinoma. 60 male Wistar rats (weighing 190 ± 8 g) were randomly divided into 3 groups (experimental group, control group, and sham operation group; 20 rats in each group). The 3 groups were fed with standard diet. Read More

Clin Exp Dermatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Cellular Pathology, St. George's Hospital, London, UK.

Granular cell tumours are rare soft tissue neoplasms which occur at a wide variety of sites and commonly involve the skin. Distinction between benign and malignant granular cell tumours is important because benign tumours are commonly cured by complete excision and malignant tumours commonly recur and cause fatal metastatic disease. Communication between the dermatologist and pathologist is also important, as the pathologist may provide false reassurance by evaluating a benign appearing part of a clinically malignant tumour. Read More

Iran J Kidney Dis 2022 May;16(3):203-208

Department of Maxillofacial Radiology, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: This study aimed to investigate the relationship between serum levels of PTH and dental and bone changes in the panoramic view of hemodialysis patients.

Methods: Out of 236 patients with end-stage kidney disease (ESKD) who were hospitalized in two hemodialysis centers, 68 ones were selected and concerning their PTH serum levels, they were assigned to case group (PTH > 300 pg/mL) and control group (150 < PTH < 300 pg/mL). Patients in both groups had undergone dialysis for at least 6 months. Read More

Am J Surg Pathol 2022 Jun 20. Epub 2022 Jun 20.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that shows overlapping features with PRDM10-rearranged soft tissue tumor (PRDM10-STT). This study characterizes the clinicopathologic, immunohistochemical, and molecular features of SCD34FT in a series of 59 cases. Fluorescence in situ hybridization to assess for PRDM10 rearrangement was performed in 12 tumors. Read More

Evid Based Complement Alternat Med 2022 6;2022:3642349. Epub 2022 Jun 6.

Department of Gynaecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Background: Although triptolide (TP) has been widely used for the treatment of inflammatory, autoimmune diseases, and various kinds of tumors, the long experimental and clinical applications have exhibited severe reproductive system toxicity in TP-treated animals and patients. More importantly, the underlying molecular mechanism involved in TP-induced reproductive system toxicity still needs more research.

Methods: Adult female Sprague Dawley rats and human ovarian granulosa cell lines were treated with TP and then treated with XinJiaCongRongTuSiZiWan (XJCRTSZW). Read More

J Korean Med Sci 2022 Jun 13;37(23):e184. Epub 2022 Jun 13.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: No definite guidelines for the management of small esophageal subepithelial tumors (SETs) have been established, because there are limited data and studies on their natural history. We aimed to assess the natural history and propose optimal management strategies for small esophageal SETs.

Methods: Patients diagnosed as esophageal SETs ≤ 30 mm in size between 2003 and 2017 using endoscopic ultrasound (EUS) with a minimal follow-up of 3 months were enrolled, and their esophagogastroduodenoscopy (EGD) and EUS were retrospectively reviewed. Read More

Diagnostics (Basel) 2022 Apr 27;12(5). Epub 2022 Apr 27.

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Alveolar soft part sarcoma (ASPS) is a rare malignant mesenchymal tumor mainly affecting adolescents and young adults, with a predilection for the deep soft tissues of extremities. ASPS arising in the female genital tract is extremely rare and poses a significant diagnostic challenge. We herein present two rare cases of ASPS, one occurring in the uterine corpus of a 27-year-old woman, and the other in the uterine cervix of a 10-year-old girl. Read More

Sci Rep 2022 May 24;12(1):8741. Epub 2022 May 24.

Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.

The study objective was to detect the expression of farnesoid X receptor (FXR) in a rat model of hilar cholangiocarcinoma to provide a new therapeutic target for gene therapy in hilar cholangiocarcinoma. Sixty male Wistar rats (weighing 190 ± 8 g) were randomly divided into three groups (experimental group, control group and sham operation group, 20 rats in each group). The three groups were fed a standard diet. Read More

Int J Surg Case Rep 2022 Jun 11;95:107193. Epub 2022 May 11.

Department of General Surgery, Clínica Universitaria Reina Fabiola, Universidad Católica de Córdoba, Oncativo 1248. Córdoba Capital, Argentina. Electronic address:

Introduction And Importance: Granular cell tumors (GCT) are rare neoplasms. The most common places are the head and neck. The larynx accounts for 3-10% of cases. Read More

Scand J Gastroenterol 2022 May 16:1-8. Epub 2022 May 16.

Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.

Background And Aim: Diagnosis and complete resection of esophageal granular cell tumors (GCTs) is an area of concern. However, articles on endoscopic ultrasound (EUS) and endoscopic resection of esophageal granular cell tumors are few. To evaluate the role of endoscopic ultrasound and endoscopic resection in the diagnosis and treatment of esophageal granular cell tumors. Read More

Indian J Pathol Microbiol 2022 May;65(Supplement):S24-S32

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.

Glioblastoma is the most common malignant central nervous system (CNS) tumor in adults. Acute common clinical symptoms include headache, seizure, behavior changes, focal neurological deficits, and signs of increased intracranial pressure. The classic MRI finding of glioblastoma is an irregularly shaped, rim-enhancing or ring-enhancing lesion with a central dark area of necrosis. Read More

Endocr Connect 2022 Jun 17;11(6). Epub 2022 Jun 17.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China.

Introduction: Most studies reporting posterior pituitary tumors (PPTs) are small case series or single cases.

Methods: Patients with a histological diagnosis of PPT from January 2010 to December 2021 in a tertiary center were identified. We reported clinical symptoms, endocrine assessments, radiological and pathological features, and surgical outcomes of PPTs. Read More

Eur J Endocrinol 2022 Jun 1;187(1):K13-K18. Epub 2022 Jun 1.

Department of Pediatric Endocrinology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.

Objective: The aim of this study was to assess the prevalence of ovarian and paraovarian adrenal rest tumors (ARTs) in gonadectomy materials of a subgroup of congenital adrenal hyperplasia (CAH) patients.

Methods: A total of 20 historical cases with clinical/molecular diagnosis of classical CAH were included in the study. All patients had 46,XX karyotype and underwent gonadectomy because of being raised as male. Read More

Urol Case Rep 2022 May 16;42:102034. Epub 2022 Feb 16.

Department of Urology, Sulaymaniyah Teaching Hospital, Sulaymaniyah, Iraq.

Granular cell tumors (GCT) are uncommon tumors that originate in any part of the body. They have been mainly observed in the skin and soft tissue of the head and neck, and are mostly benign tumors. Urinary bladder GCT are extremely rare tumors. Read More

Case Rep Gastroenterol 2022 Jan-Apr;16(1):216-222. Epub 2022 Mar 31.

Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

This report describes a granular cell tumor (GCT) with insufficient endoscopic manipulation in the hepatic flexure (HF) of the colon, which was treated by endoscopic submucosal dissection (ESD) using a splinting tube and the spring S-O clip traction method. A 44-year-old man presented with a 10 mm subepithelial tumor in the HF near the ascending colon on colonoscopy. The lesion had a smooth surface without erosion. Read More

Zhonghua Bing Li Xue Za Zhi 2022 May;51(5):437-443

Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo 315000, China.

To study the clinicopathological features, immunophenotype, molecular changes, differential diagnosis and prognosis of eosinophilic vacuolated tumor (EVT) of the kidney. Four cases were collected retrospectively from 2014 to 2020 at Ningbo Diagnostic Pathology Center. The clinicopathologic features and immunophenotypic profile were studied by light microscopy and immunohistochemistry. Read More

Indian J Hematol Blood Transfus 2022 Apr 4;38(2):235-245. Epub 2021 Jun 4.

Department of Public Health Dentistry, SCB Dental College and Hospital, Cuttack, India.

To study the cyclooxygenase 2 (Cox 2) expression in newly diagnosed plasma cell myeloma cases by immunohistochemistry (IHC) and correlate with clinicohematological characteristics. Immunohistochemical expression of Cox 2 on bone marrow trephine biopsy was studied in newly diagnosed myeloma [56 males, 17 females, median age; 58 years (36-75)] and fifteen controls using SP21 clone antibody. A median immuno-score (proportion x intensity) stratified the entire cohort into low and high expressors. Read More

J Stomatol Oral Maxillofac Surg 2022 Apr 26. Epub 2022 Apr 26.

Praticien hospitalier du service de chirurgie maxillo-faciale et orale de l'hôpital Saint-Joseph, Paris, France.

Granular cell tumors are rare tumors with multiple localizations. The most common localizations are in the cervicofacial region in 45-65% of cases. The characterization of this tumor depends on its clinical and histopathological findings. Read More

J Immunoassay Immunochem 2022 Apr 27:1-14. Epub 2022 Apr 27.

Department of Cytopathology, "Venizeleio-Pananeio" General Hospital, Heraklion, Crete, Greece.

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy that arises from the parafollicular cells (C cells) secreting calcitonin. This study summarizes our experience in the diagnosis of MTC with ultrasound-guided thyroid FNA, subsequently processed with liquid-based cytology (LBC) and immunocytochemistry (ICC). We searched our laboratory archives for thyroid FNA cases with an interpretation of positive or suspicious for MTC, during the period 2004-2018. Read More

Diagn Cytopathol 2022 Apr 26. Epub 2022 Apr 26.

Division of Pathology, Nippon Medical School Hospital, Tokyo, Japan.

Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64-year-old Japanese man who presented with a 14 × 20 cm mass in the left inguinal region. Read More

Diagnostics (Basel) 2022 Apr 2;12(4). Epub 2022 Apr 2.

Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

A 66-year-old man presented with a 2.8 cm lesion of the left vocal cord. On contrast-enhanced computed tomography scans, the tumor extended to the supraglottis, subglottis, paraglottic space and anterior commissure, causing partial obstruction of the laryngeal lumen. Read More

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S77-S79. Epub 2022 Feb 28.

Department of Laboratory of Lasers in Dentistry (LELO), University of Sao Paulo (USP), Brazil.

Congenital epulis (CE) is a rare condition in newborns, whose histogenesis remains unclear. It mostly presents as a circumscribed mass in the maxilla alveolar ridge of female neonates and can interfere with their normal breathing and breastfeeding. This benign oral lesion usually appears as a pedunculated nodule covered with normal mucosa that extends from the anterior vestibular alveolar ridge up to the posterior region. Read More

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S91-S95. Epub 2022 Feb 28.

Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana, India.

Small cell neuroendocrine carcinoma (SNEC) was first described in the 19 century which is usually seen in association with lung cancer and is very rare in the oral cavity. Here, we report one such case in a 39-year-old male patient who presented with swelling on the left middle third of the face for 6 months. This is the 12 SNEC of oral cavity case so far reported in the English literature and the third case to be present on buccal mucosa. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):381-386

Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Background And Aim: Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphomas (ALK-LBCLs) are aggressive CD20-negative lymphomas, accounting for <1% of diffuse LBCLs. Being rare and with peculiar immunophenotypic characteristics, these can be easily misdiagnosed. We present 11 cases of ALK-LBCLs diagnosed over a period of 11 years at a tertiary care hospital in South India to analyze the clinical, morphological, and immunophenotypic profile of these tumors. Read More

Clin Case Rep 2022 Apr 12;10(4):e05691. Epub 2022 Apr 12.

Department of Dermatology Habib Thameur Hospital of Tunis Tunis Tunisia.

The aim of my clinical image is to recall this rare and benign tumor and to emphasize the role of dermoscopy in the diagnosis. Read More

Int J Mol Sci 2022 Mar 22;23(7). Epub 2022 Mar 22.

Division of Chinese Medicine Obstetrics and Gynecology, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.

When activated by thrombin, the platelets release their granular store of factors. These thrombin-activated platelets (TAPLT) have been shown to be capable of ameliorating pro-inflammatory processes. In this study, we tested if TAPLT could also protect the endothelium against tumor-related pro-inflammatory changes that promote angiogenesis and metastasis. Read More

Histopathology 2022 Jul 4;81(1):32-43. Epub 2022 May 4.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Aims: Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a recently described renal tumour entity with frequent cytokeratin (CK)20 positivity, commonly harbouring TSC mutations. In contrast, frequency of CK20 expression and presence of TSC mutations are unclear in TFEB-amplified RCC and TFEB-translocated RCC, which frequently express Melan A. Herein, we provide a comparative analysis of six ESC RCC with four TFEB-amplified/translocated RCC. Read More

Int J Surg Case Rep 2022 May 6;94:107031. Epub 2022 Apr 6.

Division of Surgery, Istituto Auxologico Italiano IRCCS, Piazzale Brescia, 20, 20149 Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.

Introduction And Importance: Granular cell tumor (GCT) is a rare neurogenic neoplasm originating from Schwann cells that predominantly affects women and can involve skin and mucousae. In the respiratory system it most frequently involves bronchi and larynx, while it is rare in the trachea.

Case Presentation: A 26-year old female smoker was hospitalized for a suspected hypoechoic nodule in the right thyroid lobe closely adherent to the trachea. Read More

Interact Cardiovasc Thorac Surg 2022 Apr 7. Epub 2022 Apr 7.

Division of Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.

Granular cell tumours are usually benign with a 1-2% incidence of malignancy. They are less sensitive to radiotherapy and chemotherapy and are treated by surgical excision. We report a case of a malignant granular cell tumour located at the interventricular septum. Read More

Cureus 2022 Mar 3;14(3):e22829. Epub 2022 Mar 3.

Pathology, ESTEVA Patología Diagnóstica, Santo Domingo, DOM.

Granular cell tumors (GCTs) are uncommon neoplasms of unknown origin that can manifest in multiple locations throughout the body. Physicians should be aware of this type of tumor presenting in unusual locations such as the larynx, particularly in pediatric patients with stridor and dysphonia. We describe an 11-year-old female with a large laryngeal mass that obstructed the majority of the laryngeal lumen. Read More