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J Immunother Cancer 2021 Jun;9(6)

State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Background: The clinical benefits of antiprogrammed cell death protein 1 (PD-1) therapy are compromised by resistance in immunologically cold tumors. Convergence of immunotherapy and bioengineering is potential to overcome the resistance. Mesoporous silica nanoparticles (MSNs) are considered the most promising inorganic biological nanomaterials for clinical transformation, however, the fundamental influence of MSNs on immunotherapy is unclear. Read More

Diagn Pathol 2021 Jun 8;16(1):49. Epub 2021 Jun 8.

Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Box 356100, 1959 NE Pacific St, Seattle, WA, 98195, USA.

Background: Esophageal granular cell tumor (eGCT) is rare, and the recent literature suggests a link between eosinophilic esophagitis (EoE) and eGCT. The aim of our study was to determine if EoE or other disorders associated with eosinophilia are consistently associated with eGCT.

Methods: We retrospectively searched pathology databases of three academic institutions from 1999 to 2018 for eGCTs. Read More

Rev Med Inst Mex Seguro Soc 2020 ;58(2):212-215

Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica del Noreste, Departamento de Fisiología Celular y Genética. Monterrey, Nuevo León, México.

Background: The newborn congenital epulis or granular cell tumor is a benign tumor that appears in the oral cavity of newborns with more frequency in the gingiva of the alveolar crest of the maxilla at the level of the incisive and canine area, predominantly in the female sex. It is of diagnostic importance since it can interfere with feeding, swallowing and via area, putting the health of the newborn at risk. It usually involutes spontaneously and in case of surgical treatment there are no reports of recurrence. Read More

Urol Case Rep 2021 Sep 29;38:101669. Epub 2021 Mar 29.

Department of Urology, Sapienza University, Rome, Italy.

Granular cell tumors (GCTs) are rare neoplasms of neural origin and usually tend to have a benign behaviour. We report a case of a 54 years old woman with severe gross hematuria caused by an atypical granular cell tumor which was successfully managed with a transurethral resection of the bladder (TURB). No local recurrence was observed after a three-year follow-up. Read More

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S94-S98. Epub 2021 Mar 19.

Department of Oral Pathology and Microbiology, Mar Baselios Dental College, Kothamangalam, Kerala, India.

Squamous odontogenic tumor (SOT) is a rare benign neoplasm and may be located to multiple sites in the oral cavity mouth. As per the literature, there have been <50 reported cases. The tumor is often asymptomatic, although it can present with symptoms of pain and tooth mobility. Read More

Biomater Sci 2021 May 19. Epub 2021 May 19.

School of Materials Science and Engineering, University of New South Wales, Sydney, NSW 2052, Australia. and School of Chemistry, Australian Centre for Nanomedicine, University of New South Wales, Sydney, NSW 2052, Australia.

The tissue microenvironment contains a complex assortment of multiple cell types, matrices, and vessel structures, which is difficult to reconstruct in vitro. Here, we demonstrate model tumor microenvironments formed through direct writing of vasculature channels and tumor cell aggregates, within a cell-laden microgel matrix. Photocrosslinkable microgels provide control over local and global mechanics, while enabling the integration of virtually any cell type. Read More

Gynecol Oncol Rep 2021 May 23;36:100767. Epub 2021 Apr 23.

Pathology, Academic Hospital, İstanbul, Turkey.

•Abrikossoff tumor is a rare tumor but not always benign.•Re-excission for positive margins in benign tumors may not be invariably necessary.•Cosmetic issues may play role in the treatment and follow-up in benign tumors. Read More

Ann Med Surg (Lond) 2021 May 26;65:102271. Epub 2021 Apr 26.

Division of Surgery Gastroentelogical Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Introduction: and importance: Granular cell tumor (GCT) is a benign, mesenchymal tumor that originates from Schwann cells.

Case Presentation: A 75-year-old Japanese woman was referred to our hospital due to epigastric discomfort. Upper gastrointestinal endoscopy revealed an ulcerated cancer lesion, approximately 1. Read More

Ann Surg Oncol 2021 May 14. Epub 2021 May 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Phyllodes tumors are rare fibroepithelial neoplasms that are classified by tiered histopathologic features. While there are protocols for the reporting of cancer specimens, no standardized reporting protocol exists for phyllodes.

Methods: We performed an 11-institution contemporary review of phyllodes tumors. Read More

J Surg Case Rep 2021 Apr 24;2021(4):rjab145. Epub 2021 Apr 24.

Department of Pathology, Cornwall Regional Hospital, Montego Bay, Jamaica.

Granular cell tumours of the scalp are rare. Malignant transformation of these tumours is even more uncommon, making the diagnosis exceedingly difficult. The recommended treatment of surgical excision with negative margins is not easily achieved in this location, given the anatomy of the scalp. Read More

Int J Appl Basic Med Res 2021 Apr-Jun;11(2):111-113. Epub 2021 Apr 8.

Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especially tongue. The origin of this neoplasia, after remaining a controversy for years, was finally identified to be from Schwann cell or neuroendocrine cell. They usually present as asymptomatic, firm, sessile, submucosal, solitary, or multiple nodule/papule like lesions. Read More

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Department of Pathology, Japanese Red Cross Akita Hospital, Akita, Japan.

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Read More

Diagn Pathol 2021 Apr 23;16(1):35. Epub 2021 Apr 23.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.

Background: Small cell neuroendocrine carcinoma of the prostate (SCNECP) is a rare, aggressive subtype of prostate carcinoma. Most SCNECP arise from conventional prostate adenocarcinoma (CPAC) treated with androgen deprivation therapy (ADT).

Case Presentations: We identified four cases of CPAC treated with ADT, which evolved to SCNECP with liver metastasis. Read More

Vet Pathol 2021 Apr 23:3009858211009779. Epub 2021 Apr 23.

311308Purdue University, West Lafayette, IN, USA.

Malakoplakia in humans most often affects the urinary bladder and is characterized by inflammation with von Hansemann-type macrophages, with or without Michaelis-Gutmann bodies, and is frequently associated with infection. We describe the microscopic features of malakoplakia in the urinary bladder of 4 puppies. In all cases, the lamina propria of the urinary bladder was markedly expanded by sheets of large, round to polygonal macrophages with intracytoplasmic, periodic acid-Schiff-positive granules and granular inclusions, and rare Prussian blue-positive inclusions. Read More

Pathologe 2021 May 20;42(3):333-351. Epub 2021 Apr 20.

Institute für Pathologie und Neuropathologie, Universität Hamburg, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.

The 2017 WHO classification of pituitary tumors is still based on structural analyses and expression of various pituitary hormones. Three innovations have to be considered: (1) The expression of pituitary transcription factors Pit‑1, T‑Pit and SF‑1. (2) The term "atypical adenoma" was replaced by "aggressive adenoma". Read More

J Clin Immunol 2021 Apr 19. Epub 2021 Apr 19.

University of Freiburg, Freiburg, Germany.

Purpose: Common variable immune deficiency (CVID) confers an increased risk of lymphoid neoplasms, but reports describing the precise WHO specification of the lymphoma subtypes and their immunological environment are lacking. We therefore classified lymphomas-occurring in a cohort of 21 adult CVID patients during a 17-year period at our center-according to the 2016 WHO classification and characterized the local and systemic immunological context RESULTS: The median time between the onset of CVID and lymphoma was 14 years. Patients showed a high prevalence of preceding immune dysregulation: lymphadenopathy (n = 13, 62%), splenomegaly (n = 18, 86%), autoimmune cytopenia (n = 14, 67%), and gastrointestinal involvement (n = 15, 71%). Read More

J Belg Soc Radiol 2021 Apr 5;105(1):18. Epub 2021 Apr 5.

AZ Sint-Maarten, BE.

Granular cell tumors are rare soft tissue tumors that may occur in the breast. While almost always benign, they may mimic a malignant tumor both clinically and on imaging. Read More

Transl Androl Urol 2021 Mar;10(3):1506-1520

Department of Pathology and Molecular Pathology, University and University Hospital Zurich, CH-8091 Zurich, Switzerland.

In 1952, renal cell carcinomas had been divided into 2 categories-clear cell or granular cell-depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the addition of tumors named by their architectural pattern (i.e. Read More

Surg Case Rep 2021 Apr 13;7(1):90. Epub 2021 Apr 13.

Department of Pathology, NHO Kanazawa Medical Center, 1-1 Shimoishibikicho, Kanazawa, Ishikawa, 920-8650, Japan.

Background: Pancreatic acinar cell carcinoma (PACC) is a rare exocrine malignant tumor. Its widespread intraductal extension into the main pancreatic duct (MPD) is also rare.

Case Presentation: We report the case of a 71-year-old man with PACC with MPD extension. Read More

J Clin Oncol 2021 May 6;39(14):1563-1574. Epub 2021 Apr 6.

St Bartholomew's Hospital, London, United Kingdom.

Purpose: The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990.

Materials And Methods: Data on 9,728 men with metastatic nonseminomatous germ cell tumors treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Europe, North America, and Australia. Clinical trial and registry data were included. Read More

Am J Hematol 2021 07 24;96(7):772-780. Epub 2021 Apr 24.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Large granular lymphocytic leukemia (LGLL) is a rare hematological malignancy that arises from cytotoxic T lymphocytes (T-LGLL) in 85% of cases and natural killer (NK) cells in the rest. A significant knowledge gap exists regarding the pathogenesis, treatment choices, and prognostic factors of LGLL. We report a cohort of 319 consecutive LGLL patients who presented to our cancer center between 2001 and 2020. Read More

Exp Ther Med 2021 May 23;21(5):536. Epub 2021 Mar 23.

Anatomic Pathology Service, 'Pius Brînzeu' County Emergency Clinical Hospital, 300723 Timisoara, Romania.

A granular cell tumor (GCT) is a rare neoplasia that originates from Schwann cells. It usually appears in the skin or soft tissues, but it may occur anywhere in the body. The gastrointestinal tract is an unusual developmental site for a GCT, the esophagus being the most common site of origin for this tumor. Read More

Ann Dermatol Venereol 2021 Apr 1. Epub 2021 Apr 1.

Cabinet Mathurin Moreau Paris 19, 35, avenue Mathurin Moreau, 75019 Paris, France.

J Pak Med Assoc 2021 Feb;71(Suppl 2)(2):S146-S150

Department of Anatomical Pathology, Universitas Indonesia, Jakarta, Indonesia.

Steroid cell tumours are rare type of sex cord-stromal tumour of the ovary, with the average age at diagnosis during the fourth decade of life. A 2-year-old girl presented with virilisation, precocious pseudopuberty and Cushing syndrome. Her morning cortisol level was elevated and there was left lower abdominal mass found in radiological examination. Read More

Pediatr Neurosurg 2021 29;56(3):279-285. Epub 2021 Mar 29.

Nerosurgery Unit, Instituto Nacional de Salud del Niño San Borja, Lima, Peru.

Introduction: Lhermitte-Duclos disease (LDD), also known as dysplastic cerebellar gangliocytoma, is an uncommon disorder in children, characterized by being a slow-growing lesion of the posterior fossa, which mainly affects the granular cell layer of the cerebellar parenchyma and may be associated with other multiple hereditary hamartomas and neoplasms.

Case Presentation: We report 2 cases of LDD in pediatric patients and describe clinical symptoms and radiological and histopathological characteristics. In addition, we analyzed the relation to Cowden Syndrome based on the International Cowden Syndrome Consortium Operational Criteria and the most updated guidelines by the National Comprehensive Cancer Network (NCCN Guidelines Version 1. Read More

Case Rep Oncol 2021 Jan-Apr;14(1):303-308. Epub 2021 Mar 3.

Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.

Granular cell tumor (GCT) is a benign tumor arising from Schwann cells. GCT of the breast is rare and while predominantly benign, it can be difficult to differentiate from breast cancer by imaging. While it is not generally associated with breast cancer, we here report a rare case of GCT coexisting with ductal carcinoma in situ (DCIS). Read More

Am J Dermatopathol 2021 Mar 9. Epub 2021 Mar 9.

Department of Pathology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; Department of Pathology, Stanford University School of Medicine, Stanford, CA; Department of Dermatology, Stanford University School of Medicine, Stanford, CA; Department of Pathology, Veterans Affairs Central California Health Care System, Fresno, CA; and Cytogenetics Laboratory, Department of Pathology, Stanford Health Care, Palo Alto, CA.

Abstract: Atypical fibroxanthoma (AFX) is a neoplasm that most commonly occurs on sun-damaged skin of the head and neck in elderly patients and that usually exhibits indolent clinical behavior with complete excision. The granular cell variant of AFX demonstrates overlapping histopathologic features with dermal non-neural granular cell tumor (NNGCT), which typically arises on the extremities of young to middle aged adults with rare reports of regional metastasis. A subset of NNGCT harbors ALK rearrangements and expresses ALK by immunohistochemistry. Read More

Am Surg 2021 Mar 20:3134821989047. Epub 2021 Mar 20.

Department of Surgery, 7831University of South Florida, Tampa, FL, USA.

Background: Granular cell tumors, derived from neural crest cells, are rare tumors infrequently located in the colon or rectum. We will discuss a patient with a rectal granular cell tumor invading the anal sphincters requiring an abdominoperineal resection.

Methods: A 56-year-old male, with anal pain, was found to have a perirectal mass. Read More

J Ovarian Res 2021 Mar 20;14(1):48. Epub 2021 Mar 20.

Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Polycystic ovary syndrome (PCOS) is the most common hormonal disorder among reproductive-aged women worldwide, however, the mechanisms and progression of PCOS still unclear due to its heterogeneous nature. Using the human granulosa-like tumor cell line (KGN) and PCOS mice model, we explored the function of lncRNA UCA1 in the pathological progression of PCOS.

Results: CCK8 assay and Flow cytometry were used to do the cell cycle, apoptosis and proliferation analysis, the results showed that UCA1 knockdown in KGN cells inhibited cell proliferation by blocking cell cycle progression and promoted cell apoptosis. Read More

Curr Treat Options Oncol 2021 Mar 20;22(5):38. Epub 2021 Mar 20.

Department of Medicine, Division of Medical Oncology, Duke University, Durham, NC, 27710, USA.

Opinion Statement: Immune checkpoint blockade (ICB) has revolutionized the treatment landscape across multiple solid tumor types. In triple-negative breast cancer (TNBC), clinical benefit for the addition of ICB to chemotherapy has been shown in both the metastatic and early stage disease settings. A minority of patients with TNBC will truly benefit from ICB, with many tumors unlikely to respond, and ICB can cause additional toxicities for patients to incur. Read More