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JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

Cureus 2019 Feb 3;11(2):e4000. Epub 2019 Feb 3.

Pathology, University of Texas Medical Branch, Galveston, USA.

Background Benign mesenchymal tumors of the breast are rare and may mimic invasive carcinoma on imaging and morphology, thus becoming clinically challenging for clinicians, radiologists, and pathologists. To improve the understanding of these lesions and to avoid erroneous diagnosis and inappropriate treatment, we report our institution's experience with seven cases of granular cell tumor (GCT) and myofibroblastoma (MFB) in the past 10 years. Materials and methods Seven cases of benign mesenchymal tumors of the breast were identified at the University of Texas Medical Branch from 2008 to 2018. Read More

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Ankara University, Faculty of Medicine, Department of Pathology, Ankara, Turkey.

Cutaneous adnexial tumours derived from the outer root sheath of hair follicles are trichilemmal tumours or pilar cysts. These tumours show trichilemmal keratinization as formation of a dense keratin layer without interposition of the granular cell layer. Trichilemmal cysts can form rapidly multiplying trichilemmal tumors, also called proliferating trichilemmal tumour (PTT) or cyst. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):330-331

Department of Pathology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

Breast J 2019 Apr 6. Epub 2019 Apr 6.

Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania.

Abdom Radiol (NY) 2019 Apr 6. Epub 2019 Apr 6.

Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Purpose: To review the pertinent anatomy and the imaging features of common and uncommon benign and malignant neoplasms and masses of the ischiorectal fossa.

Results: The ischiorectal or ischioanal fossa is the largest space in the anorectal region. The benign neoplasms that develop in the ischiorectal originate from the different components that forms the fossa including vascular tumors such as aggressive angiomyxoma or hemangioma; neural tumors as plexiform neurofibroma or schwannoma; fat tumors as lipoma; skin/skin appendages tumors as hidradenoma papilliferum; smooth or skeletal muscle tumors as solitary fibrous tumor. Read More

Pan Afr Med J 2018 13;31:28. Epub 2018 Sep 13.

Service d'Hématologie CHU Mohammed VI, Marrakech, Maroc.

Aggressive natural killer cell leukemia (ANKL) is a disease entity within the spectrum of lymphoproliferative syndromes of NK cells. It is rare, preferentially affecting Asiatic people. It has been very rarely reported in the African population; hence the interest of our case. Read More

SAGE Open Med Case Rep 2019 19;7:2050313X19838184. Epub 2019 Mar 19.

Pôle d'Odontologie, Hôpital Maison Blanche, Centre Hospitalier Universitaire Reims, Reims, France.

Schwannomas are benign peripheral nerve sheath tumors originating from the Schwann cells. Most schwannomas in the head and neck region are solitary; however, multiple schwannomas affecting one or more nerves suggest a possible association with neurofibromatosis type 2 and schwannomatosis. Plexiform schwannoma is a rare variant of conventional schwannoma that is characterized by intraneural multinodular growth. Read More

Rev Esp Cir Ortop Traumatol 2019 May - Jun;63(3):239-245. Epub 2019 Mar 21.

Hospital de Ortopedia Dr. Victorio de la Fuente Narváez, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Introduction: Perivascular epithelioid cell (PEC) is a cell type constantly present in a group of tumours including angiomyolipoma (AML), clear-cell «sugar» tumour (CCST) of the lung and extrapulmonary sites, lymphangioleiomyomatosis (LAM), and clear-cell tumours of other anatomical sites. It has morphologic distinctive features: epithelioid appearance with a clear to granular cytoplasm, a round to oval, centrally located nucleus and an inconspicuous nucleolus. Immunohistochemically, PEC expresses myogenic and melanocytic markers. Read More

Int J Surg Pathol 2019 Mar 21:1066896919836499. Epub 2019 Mar 21.

1 The Affiliated Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu Province, China.

Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Read More

Head Neck Pathol 2019 Mar 19. Epub 2019 Mar 19.

Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada.

Congenital granular cell epulis (CGCE) is an uncommon lesion of unclear pathogenesis. It occurs predominantly in female newborns with a predilection site of the maxillary alveolar ridge. The mass enlarges prenatally but the growth arrests after birth. Read More

Rev Prat 2018 Dec;68(10):1103

Service de dermatologie, hôpital Charles-Nicolle, université Tunis El Manar, Tunis, Tunisie.

Rev Endocr Metab Disord 2019 Mar 12. Epub 2019 Mar 12.

Department of Endocrinology, Bellvitge University Hospital, Carrer de la Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

In 2017, the World Health Organization established that pituicytoma, granular cell tumor (GCT), spindle cell oncocytoma (SCO) and sellar ependymomas (SE) are posterior pituitary tumors (PPT). They probably arise from the pituicytes and may constitute a unique histopathological entity. We carried out a systematic review using PubMed's database. Read More

Int J Nanomedicine 2019 15;14:1177-1191. Epub 2019 Feb 15.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China,

Background: Treatment for melanoma is a challenging clinical problem, and some new strategies are worth exploring.

Purpose: The objective of this study was to investigate the in vitro and in vivo anti-melanoma effects of hydroxyapatite nanoparticles (HANPs) and discuss the involved material factors.

Materials And Methods: Five types of HANPs, ie, HA-A, HA-B, HA-C, HA-D, and HA-E, were prepared by wet chemical method combining with polymer template and appropriate post-treatments. Read More

Clin Cosmet Investig Dermatol 2019 13;12:123-132. Epub 2019 Feb 13.

Compass Dermatopathology, San Diego, CA, USA.

Painful tumors of the skin present as dermal or subcutaneous nodules. They can originate from several sources: adipose tissue, cartilage degeneration, deposition of bone or calcium, eccrine glands, fibrous tissue, infiltration of benign (endometrium) or malignant (metastatic neoplasm) tissue, muscle, nerve, or vascular structures. Although pathologic evaluation of the lesion is necessary to determine the diagnosis, it is possible to make a reasonable differential diagnosis based on knowledge of prior tumors that have appeared as tender lesions. Read More

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

General Surgery Department, Hospital Sao Francisco Xavier, Lisboa, Portugal.

Granular cell tumours are rare neoplasms that may occur anywhere in the body. The most common locations are the oral cavity, skin and subcutaneous tissue, with only 8% of these tumours occurring at a gastrointestinal site. In the specific case of gastric granular cell tumours, only a few cases have been published until today. Read More

J Gastrointest Surg 2019 Feb 28. Epub 2019 Feb 28.

Hospital Universitario 12 de Octubre, Av. Cordoba, s/n, 28041, Madrid, Spain.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. Read More

Autops Case Rep 2018 Oct-Dec;8(4):e2018052. Epub 2018 Oct 9.

Universidade de São Paulo (USP), School of Dentistry, Department of Stomatology. São Paulo, SP, Brazil.

Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. Read More

VideoGIE 2019 Feb 11;4(2):58-61. Epub 2019 Jan 11.

Faculty of Medicine, Department of Medicine II, University Hospital Freiburg, University of Freiburg, Freiburg, Germany.

Rinsho Ketsueki 2019;60(1):39-45

Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

T-cell large granular lymphocyte (T-LGL) leukemia is a chronic T-cell monoclonal disease that is occasionally associated with pure red cell aplasia (PRCA). A 71-year-old previously healthy man complained of physical fatigue and exhibited anemia (hemoglobin, 10.5 g/dl) with lymphocytosis (76%) showing LGL. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):79-81

Department of Pathology, Hospital Militar Central, Universidad Militar Nueva Granada, Bogotá, Colombia.

We report the case of a 47-year-old male patient with S100 negative granular cell tumor of the oral cavity, focusing on dermoscopic features as well as surgical approach, not previously reported in the literature. The study contributes to the literature on dermoscopy and surgical treatment for this tumor and provides a practical approach to differentiating non-neural granular cell tumors and granular cell tumors. Read More

Clin J Gastroenterol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, Kitasato University School of Medicine, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.

Pancreatic granular cell tumors (GCTs) are rare and making an imaging diagnosis of pancreatic GCT is difficult because it has no definite characteristics on contrast-enhanced computed tomography (CE-CT) or magnetic resonance imaging (MRI) owing to varying findings. We report about a 32-year-old woman who presented with an incidental finding of a pancreatic tumor with a past history of excision of a right forearm GCT nodule 12 years ago. CE-CT revealed a 23-mm-sized homogeneous low enhancement tumor in the arterial phase in the pancreatic body. Read More

Head Neck Pathol 2019 Mar 31;13(1):33-46. Epub 2019 Jan 31.

Virginia Commonwealth University School of Dentistry, Richmond, VA, USA.

When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Read More

J Colloid Interface Sci 2019 Apr 17;541:192-203. Epub 2019 Jan 17.

Convergence of Smart Sensors Institute, Dong-Eui University, Busan, Republic of Korea; Department of Radiological Science, Dong-Eui University, Busan, Republic of Korea. Electronic address:

This article outlines the synthesis of gadolinium (Gd)-doped manganese zinc ferrite magnetic nanoparticles (MNPs) as potential magnetic carriers for magnetic fluid hyperthermia (MFH). MNPs with high specific loss power (SLP; 146 W/g) have been developed and used for an in vitro hyperthermia study. The treatment of MFH is fruitful if there is an adequate number of MNPs in tumor cells with the highest SLP to rapidly generate heat while minimizing thermal injury to surrounding healthy tissue. Read More

Gastroenterol Res Pract 2018 2;2018:2149564. Epub 2018 Dec 2.

Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Submucosal tumors (SMTs) are primarily benign tumors, but some may have a malignant potential. Endoscopic submucosal dissection that has been used for removing esophageal SMTs could cause perforation. Submucosal tunnel endoscopic resection (STER) is an improved and an effective technique for treating esophageal SMTs. Read More

Genes Chromosomes Cancer 2019 Jun 21;58(6):373-380. Epub 2019 Jan 21.

Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan.

Granular cell tumors (GCTs) are rare mesenchymal tumors that exhibit a characteristic morphology and a finely granular cytoplasm. The genetic alterations responsible for GCT tumorigenesis had been unknown until recently, when loss-of-function mutations of ATP6AP1 and ATP6AP2 were described. Thus, we performed whole-exome sequencing, RNA sequencing, and targeted sequencing of 51 GCT samples. Read More

Diagn Cytopathol 2019 Mar 27;47(3):226-229. Epub 2018 Dec 27.

Department of Pathology, Rush University Medical Center, Chicago, Illinois.

Granular cell tumors (GCT) are mesenchymal neoplasms of Schwann cell/neural origin. Malignant granular cell tumors (MGCTs) represent <1-2% of all GCT and defined as tumors demonstrating metastases or destructive local growth. Other clinical parameters suggestive of malignancy include rapid growth, size > 4 cm and necrosis. Read More

J Morphol 2019 Feb 27;280(2):205-213. Epub 2018 Dec 27.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

We evaluated the histology of the spiral intestine of the blackmouth catshark (Galeus melastomus), a small shark distributed in the eastern Atlantic and Mediterranean Sea basin. Entire digestive tracts of 10 G. melastomus were studied using histochemical, immunohistochemical, and ultrastructural methods. Read More

Indian J Dent Res 2018 Nov-Dec;29(6):830-835

Department of Conservative and Endodontics. M.A. Rangoonwala College of Dental Sciences and Research Center, Pune, Maharashtra, India.

Ameloblastoma is a benign locally aggressive type of odontogenic tumor derived exclusively from the epithelium. Histologically, ameloblastoma is classified into many variants, of which granular cell ameloblastoma (GCA) is a rare type, characterized by nest of large eosinophilic granular cells. This article describes a case of GCA in a 50-year-old female patient with clinical, radiological, and histological features along with a systematic review of the literature. Read More

Rev Esp Patol 2019 Jan - Mar;52(1):11-19. Epub 2018 Jul 6.

Departamento de Anatomía Patológica, Hospital y Fundación Médica Sur, Ciudad de México, México; Departamento de Biología Celular y Tisular, Escuela de Medicina, Universidad Panamericana, Ciudad de México, México.

Introduction And Objective: Granular cell tumour (GCT) is a benign neoplasm of neural/schwannian origin, usually presenting as a single asymptomatic lesion, mainly located in the dermis and subcutaneous tissue or submucosa, although multiple tumours may occur. Microscopically, GCTs are composed of large cells with abundant eosinophilic, granular cytoplasm arranged in sheets, nests, cords or trabeculae. Based on the cytological characteristics and the presence of necrosis, three types are recognized: benign, atypical and malignant. Read More

Diagn Cytopathol 2019 Apr 23;47(4):345-346. Epub 2018 Dec 23.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

A 46-year-old female with history of asthma, active smoking (20 pack-years), and schizophrenia was evaluated for a persistent asymptomatic pulmonary nodule. Her past medical history was notable for hypertension, obesity, polycystic ovary syndrome, abnormal uterine bleeding, multinodular thyroid gland, and vitamin D deficiency. Seven months before presentation, a chest radiograph (CXR) was obtained to evaluate unintended weight loss, and showed a 3 cm spiculated mass in the left lower lobe concerning for a primary lung malignancy. Read More

Cancers (Basel) 2018 Dec 20;11(1). Epub 2018 Dec 20.

Department of Medicine, University of Ottawa, Ottawa, ON K1H8L1, Canada.

Natural Killer (NK) cells are granular lymphocytes of the innate immune system that are able to recognize and kill tumor cells without undergoing clonal selection. Discovered over 40 years ago, they have since been recognized to possess both cytotoxic and cytokine-producing effector functions. Following trauma, NK cells are suppressed and their effector functions are impaired. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Pediatrics, Monmouth Medical Center, Long Branch, New Jersey, USA.

Congenital granular cell lesion (CGCL) is an uncommon, benign soft tissue lesion that usually arises from the alveolar mucosa of neonates. The present report describes a case of CGCL originating from the tongue of a newborn female infant. The lesion was negative for S-100 differentiating it from congenital granular cell tumour. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Molecular Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain.

Fewer than 90 cases of granular cell tumour (GCT) of the biliary tract have been reported, including only five cases of multiple GCTs. We present the unusual case of a 40-year-old woman with multifocal GCTs affecting the intrahepatic biliary tree, which were initially suspected to be hepatic multiple metastases from a malignancy of unknown origin. The surgical specimen consisted of a hepatic segment in which five whitish nodular lesions were observed. Read More

Rev Esp Enferm Dig 2019 Apr;111(4):329

Gastrenterology, Hospital de Braga, Portugal.

We read with interest the article by Sevilla Ribota et al1 that described an unexpected finding of a granular cell tumour (GCT) of the rectum, which was removed by band ligation-assisted mucosectomy. We present a similar case of a GCT of the cecum, which was resected using a different endoscopic procedure. Read More

Diagn Cytopathol 2019 Apr 18;47(4):337-340. Epub 2018 Dec 18.

Department of Pathology and Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Granular cell tumor (GCT) is a rare benign neoplasm of Schwannian origin which accounts of 0.5% of soft tissue tumors. Although the most common site for GCT is tongue, it can occur at any site. Read More

Acta Radiol Open 2018 Dec 10;7(12):2058460118816537. Epub 2018 Dec 10.

Department of Radiology, St. Marianna University School of Medicine, Kanagawa, Japan.

Granular cell tumor (GCT) is a rare neoplasm of the soft tissues and <1% of all GCTs are malignant. Initially, GCT was considered a myogenic lesion affecting the female breast (myoblastoma). We report the case of an 83-year-old woman with a palpable lump in the left breast; mammography and ultrasound showed an irregular lesion. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13624

Department of Ophthalmology, Second Hospital of Jilin University, Changchun, China.

Rationale: Occurrence of granulosa cell tumors (GCTs) in the eye are rare and may be diagnosed by imaging examination and immune-histochemical studies. Two common signs of a rectus muscle tumor are the proptosis of the eye ball and the complaint of bi-ocular diploma.

Patient Concerns: A 45-year-old man visited our ophthalmology department with an about a 3-year history of vertical diplopia. Read More

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.

Zinc finger AN1-type containing 4 (ZFAND4) has emerged as a promising prognostic marker and predictor of metastasis for patients with oral squamous cell carcinoma (OSCC). However, further validation is fundamental before clinical implementation. Hence, this study evaluated the expression pattern of ZFAND4 protein expression by immunohistochemistry using an independent cohort of 125 patients with OSCC, and correlations with the clinicopathologic parameters and disease outcome. Read More

Indian J Surg Oncol 2018 Dec 21;9(4):598-600. Epub 2018 Jul 21.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai-12, India.

Granular cell tumours are uncommon, usually benign soft tissue tumours. They are thought to be neural, arising from Schwann cells and can occur at various sites. Their occurrence in gastrointestinal tract is rare, the commonest site being oesophagus followed by large intestine. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Minia University, Minia, Egypt.

Cerebellum seems to be a specific target for both the decrease of estrogen and hypertension in menopause. The aim of this study was to investigate the hypertension and menopause-induced changes in rat's cerebellar cortex and the possible mechanisms of these changes. Rats were divided into four groups: the sham-operated control (SC-group), the ovariectomized (OVX-group), the hypertensive (H-group), and the ovariectomized-hypertensive (OVX-H-group) group. Read More

Autops Case Rep 2018 Apr-Jun;8(2):e2018025. Epub 2018 Jun 8.

a Centro Hospitalar de São João, Medical Oncology Department. Porto, Portugal.

Large-cell neuroendocrine tumors (NETs) are poorly differentiated malignancies of rare incidence and aggressive nature. NETs mostly arise in the lung followed by the gastrointestinal tract, although they are potentially ubiquitous throughout the body. Primary unknown NET has a worse prognosis and shorter survival comparing with other NETs, with limited available data in the literature concerning this subgroup. Read More

Clin Cancer Res 2019 Feb 28;25(4):1379-1388. Epub 2018 Nov 28.

Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.

Purpose: Although most children with medulloblastoma are cured of their disease, Sonic Hedgehog (SHH) subgroup medulloblastoma driven by mutations is essentially lethal. Casein kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We therefore tested a second-generation CK1α activator against -mutant, -amplified medulloblastoma. Read More

Ann Dermatol Venereol 2018 Nov;145 Suppl 5:VS3-VS11

Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:

Basal cell carcinoma (BCC) is a very common tumor, of which the diagnosis is generally easy. Clinical prediction of histopathological subtype however is however often difficult, i.e. Read More

AJR Am J Roentgenol 2019 Feb 26;212(2):450-455. Epub 2018 Nov 26.

1 Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

Objective: The purpose of this study is to describe our experience with pathologically proven breast masses at a tertiary care pediatric institution, review published management strategies, and propose new management recommendations for the pediatric population.

Materials And Methods: All pediatric breast ultrasound examinations performed at a dedicated pediatric facility over a 4-year period were reviewed. Maximum measurements of solid masses with features of a fibroadenoma were recorded. Read More

J Nippon Med Sch 2018 ;85(5):279-282

Department of Plastic, Reconstructive & Aesthetic Surgery, Nippon Medical School.

We report two cases of granular cell tumors (GCTs) arising on rare sites, namely, the nape and umbilicus. While GCTs have a very characteristic histology, their clinical signs and symptoms are non-specific. Therefore, it is extremely difficult to make a diagnosis of GCT on the basis of clinical findings only. Read More

Exp Neurol 2019 Feb 16;312:33-42. Epub 2018 Nov 16.

Institute of Cell Biology and Neurobiology, Italian National Research Council (CNR), I-00015, Monterotondo Scalo, Rome, Italy.

The G-protein coupled receptor 37-like 1 (Gpr37l1) is specifically expressed in most astrocytic glial cells, including cerebellar Bergmann astrocytes and interacts with patched 1 (Ptch1), a co-receptor of the sonic hedgehog (Shh)-smoothened (Smo) signaling complex. Gpr37l1 null mutant mice exhibit precocious post-natal cerebellar development, with altered Shh-Smo mitogenic cascade and premature down-regulation of granule cell precursor (GCP) proliferation. Gpr37l1 expression is downregulated in medulloblastoma (MB) and upregulated in glioma and glioblastoma tumors. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

A diverse spectrum of benign oral mucosal lesions exists, presenting as either isolated oral findings or in association with dermatological conditions. Oral lesions can closely resemble one another; therefore, it is important for clinicians to be able to recognize their distinctive features and recognize benign versus malignant disease and when a biopsy is warranted. In this continuing medical education series, we review oral anatomy and the clinical attributes of several benign lesions of the oral cavity along with the appropriate management and therapeutic modalities. Read More

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:620-623

Aberration in tissue architecture is an essential index for cancer diagnosis and tumor grading. Therefore, extracting features of aberrant phenotypes and classification of the histology tissue can provide a model for computer-aided pathology (CAP). As a case study, we investigate the application of convolutional neural networks (CNN)s for tumor grading and decomposing tumor architecture from hematoxylin and eosin (H&E) stained histology sections of kidney. Read More