89,644 results match your criteria Gram-Negative Toe Web Infection
J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.
J. Craig Venter Institute, Rockville, MD USA.
Capsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. Read More
PLoS One 2018 12;13(12):e0208530. Epub 2018 Dec 12.
Plant Virology Laboratory, ICAR-Indian Institute of Horticulture, Bengaluru, Karnataka, India.
Huanglongbing (HLB) or citrus greening is highly destructive disease that is affecting the citrus industry worldwide and it has killed millions of citrus plants globally. HLB is caused by the phloem limited, Gram negative, non-culturable, alpha-proteobacterium, 'Candidatus Liberibacter asiaticus'. Currently, polymerase chain reaction (PCR) and real time PCR have been the gold standard techniques used for detection of 'Ca. Read More
Rev Gastroenterol Peru 2018 Jul-Sep;38(3):301-305
Servicio de Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo. Lima, Perú; Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.
Non-O1, non-O139 Vibrio cholerae (NOVC) strains are an uncommon cause of gastroenteritis. However, they have been recently associated with severe extraintestinal infections in immunocompromised hosts. Among them, bacteremia in cirrhotic patients is noteworthy. Read More
J Water Health 2018 Dec;16(6):1029-1032
Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK E-mail: School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK and Centre for Experimental Medicine, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
The frequency of seasonal snowfall results in the transient covering of gardens/amenity sites/open public spaces, which encourages recreational interaction mainly with children. No data is available demonstrating the microbiological composition of such fallen snow and therefore a study was undertaken to examine the microbiology of snow from 37 sites, estimating (i) total viable count (TVC), (ii) identification of bacteria, and (iii) the presence of Pseudomonas aeruginosa. Mean TVC count of 8. Read More
Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.
3Northwest Hubei Research Institute of Traditional Fermented Food, College of Food Science and Technology, Hubei University of Arts and Science, Xiangyang 441053, PR China.
In a survey of endophytic bacteria in Miscanthus sinensis, a strain of Gram-negative, non-endospore-forming, rod-shaped, aerobic bacterium was isolated and designated as RS10. Phylogenetic analysis based on its 16S rRNA gene sequence showed that the strain RS10 was affiliated with the genus Pedobacter and exhibited the highest sequence similarities to Pedobacter kyungheensis KACC 16221 (97.78 %), Pedobacter roseus KCTC 22187 (97. Read More
Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.
2Department of Marine and Environmental Science, Ocean Genome Legacy Center, Northeastern University, Nahant MA 01908, USA.
A chemolithoautotrophic sulfur-oxidizing, diazotrophic, facultatively heterotrophic, endosymbiotic bacterium, designated as strain 2141T, was isolated from the gills of the giant shipworm Kuphus polythalamius (Teredinidae: Bivalvia). Based on its 16S rRNA sequence, the endosymbiont falls within a clade that includes the as-yet-uncultivated thioautotrophic symbionts of a marine ciliate and hydrothermal vent gastropods, uncultivated marine sediment bacteria, and a free-living sulfur-oxidizing bacterium ODIII6, all of which belong to the Gammaproteobacteria. The endosymbiont is Gram-negative, rod-shaped and has a single polar flagellum when grown in culture. Read More
Cien Saude Colet 2018 Dec;23(12):4231-4239
Faculdade de Ciências Humanas, Econômicas e da Saúde de Araguaína, Instituto Tocantinense Presidente Antônio Carlos. Av. Filadélfia 568, Setor Oeste. 77816-540 Araguaína TO Brasil.
Q fever is a zoonosis that is broadly distributed worldwide, despite few reports associated with its occurrence in Brazil. Coxiella burnetii, namely the causative agent of Q fever is a gram-negative coccobacillus and an obligate intracellular bacterial parasite of the order of Legionellales. The microorganism is generally present in the urine and feces of infected animals and can be found in large quantities in placental membranes of at-term or aborted animals. Read More
Future Microbiol 2018 Dec 12. Epub 2018 Dec 12.
Department of Microbiology, Government College University, Faisalabad, Pakistan.
Quorum sensing (QS) is a cell density dependent regulatory process that uses signaling molecules to manage the expression of virulence genes and biofilm formation. The study of QS inhibitors has emerged as one of the most fascinating areas of research to discover novel antimicrobial agents. Compounds that block QS have become candidates as unusual antimicrobial agents, as they are leading players in the regulation of virulence of drug-resistant pathogens. Read More
Future Microbiol 2018 Dec 12. Epub 2018 Dec 12.
Research & Development, Abbott (Alere Technologies GmbH), Jena, Germany.
Aim: A newly designed multiplex real-time PCR (rt-PCR) was validated to detect four clinically relevant Gram-negative bacteria (Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa).
Materials & Methods: Serial dilutions of genomic DNA were used to determine the limit of detection. Colony PCR was performed with isolates of the four selected species and other species as negative controls. Read More
Biomed Res Int 2018 12;2018:2649585. Epub 2018 Nov 12.
Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, China.
Increased high mobility group box 1 (HMGB1) in dialysis effluence is associated with the presence of peritoneal dialysis-related peritonitis in patients and peritoneal dysfunction in acute peritonitis mice model, but it remains unclear whether HMGB1 is involved in peritoneal mesothelial cell injury and functions via molecular posttranslational modifications by acetylation in this process. Here we first showed correlation between HMGB1 acetylation level in dialysis effluence of patients and occurrence of Gram-negative peritonitis. The increased level of acetylated HMGB1 was similarly observed under the lipopolysaccharides (LPS) treatment in both human peritoneal mesothelial cell line (HMrSV5) and mice visceral peritoneum tissue. Read More
Water Environ Res 2018 Dec;90(12):2090-2099
In this study a laboratory-scale sequencing batch bioreactor was constructed, using phenanthrene/pyrene as the sole carbon-source, to demonstrate the removal efficiencies of polycyclic aromatic hydrocarbons (PAHs) and the evolution process of a functional bacterial community. The removal rates were: COD, 51.4 to 76. Read More
Diagn Pathol 2018 Dec 11;13(1):95. Epub 2018 Dec 11.
Department of Immunology, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
Both Gram-Positive and Gram-Negative bacteria can secrete outer membrane vesicles (OMVs) in their growth and metabolism process. Originally, OMVs were considered as a by-product of bacterial merisis. However, many scientists have reported the important role of OMVs in many fields recently. Read More
Prog Transplant 2018 Dec 11:1526924818817028. Epub 2018 Dec 11.
2 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Background:: Hypogammaglobulinemia (HGG), immunoglobulin G (IgG) <700 mg/dL, is associated with infections, chronic lung allograft dysfunction, and death following lung transplantation. This study evaluates the use of on-demand intravenous IgG in lung transplant recipients with HGG.
Materials And Methods:: This single-center retrospective cohort study of adult lung recipients evaluated 3 groups, no, untreated (u), or treated (t) HGG at first IgG administration or a matched time posttransplant. Read More
FEBS J 2018 Dec 7. Epub 2018 Dec 7.
Division of Respiratory and Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
Gram-negative bacteria defend against the toxicity of polymyxins by modifying their outer membrane lipopolysaccharide (LPS). This modification mainly occurs through the addition of cationic molecules such as phosphoethanolamine (PEA). EcEptC is a PEA transferase from Escherichia coli (E. Read More
Biotechnol Bioeng 2018 Dec 8. Epub 2018 Dec 8.
School of Biosciences, University of Kent, Canterbury, U.K.
The large-scale production and isolation of recombinant protein is a central element of the biotechnology industry and many of the products have proved extremely beneficial for therapeutic medicine. Escherichia coli is the microorganism of choice for the expression of heterologous proteins for therapeutic application, and a range of high-value proteins have been targeted to the periplasm using the well characterised Sec protein export pathway. More recently, the ability of the second mainstream protein export system, the twin-arginine translocase, to transport fully-folded proteins into the periplasm of not only E. Read More
Mol Microbiol 2018 Dec 9. Epub 2018 Dec 9.
Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Envelope-localized proteins, such as adhesins and secretion systems, play critical roles in host infection by Gram-negative pathogens. As such, their folding is monitored by envelope stress response systems. Previous studies demonstrated that the Cpx envelope stress response is required for virulence of Citrobacter rodentium, a murine pathogen used to model infections by the human pathogens enteropathogenic and enterohemorrhagic Escherichia coli; however, the mechanisms by which the Cpx response promotes host infection were previously unknown. Read More
Eur J Clin Microbiol Infect Dis 2018 Dec 7. Epub 2018 Dec 7.
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
The introduction of dedicated phlebotomy teams certified for blood collection has been reported to be highly cost-effective by reducing contamination rates. However, data on their effects on blood volume and true positive rate are limited. Therefore, we investigated the effect of replacing interns with a phlebotomy team on blood culture results. Read More
Ann Intensive Care 2018 Dec 7;8(1):121. Epub 2018 Dec 7.
Critical Care Center, Parc Tauli Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.
Background: Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and biological response to hemoperfusion in patients with septic shock and acute kidney injury. Read More
Clin Infect Dis 2018 Dec 11. Epub 2018 Dec 11.
Infectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Background: Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration of antibiotic therapy are limited.
Methods: Randomized, multicenter, open-label, non-inferiority trial. Read More
Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.
Clinical Microbiology, University Hospital Basel, Basel, Switzerland.
This cohort study describes mortality predictors of necrotizing fasciitis (NF). Higher age, chronic kidney disease and higher Charlson score increased mortality rate. Mortality was more than three times higher in monomicrobial gram-negative NF than in type I or type II NF. Read More
J Antimicrob Chemother 2018 Dec 10. Epub 2018 Dec 10.
Loyola University Medical Center, Maywood, IL, USA.
Objectives: To ensure the accuracy of susceptibility testing methods for ceftazidime/avibactam.
Methods: The performances of the Etest (bioMérieux), 30/20 μg disc (Hardy diagnostics) and 10/4 μg disc (Mast Group) were evaluated against the reference broth microdilution (BMD) method for 102 clinically relevant Gram-negative organisms: 69 ceftazidime- and meropenem-resistant Klebsiella pneumoniae and 33 MDR non-K. pneumoniae. Read More
Rev Chilena Infectol 2018 ;35(3):321-325
Universidad CES, Medellín, Colombia.
Use of Intrathecal colistin has increased in recent years and has become an alternative for the management of infections of the central nervous system caused by multidrug resistant (MDR) bacteria. Evidence of therapeutic success and safety profile is increasing, particularly in MDR Acinetobacter baumanii infections in adults. Conversely, evidence in children is limited. Read More
Rev Chilena Infectol 2018 ;35(3):246-252
Servicio de Medicina Interna, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.
Introduction: Nosocomially acquired urinary tract infections (NAUTI) represent an important public health issue, but its characteristics when they are not catheter associated (CA-UTI) or when they take place outside intensive care units (ICU) are poorly understood.
Objectives: To determine the patients' characteristics, etiology and antimicrobial susceptibility of NAUTI, both CA-UTI and no CA-UTI, in general ward and ICU.
Methods: We conducted a retrospective analytic cross-sectional study, between 2009 and 2013, in a third level universitary hospital. Read More
Photochem Photobiol Sci 2018 Dec 11. Epub 2018 Dec 11.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
We have recently shown that a wide range of different inorganic salts can potentiate antimicrobial photodynamic inactivation (aPDI) and TiO2-mediated antimicrobial photocatalysis. Potentiation has been shown with azide, bromide, thiocyanate, selenocyanate, and most strongly, with iodide. Here we show that sodium nitrite can also potentiate broad-spectrum aPDI killing of Gram-positive MRSA and Gram-negative Escherichia coli bacteria. Read More
BMC Hematol 2018 4;18:35. Epub 2018 Dec 4.
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200 Thailand.
Background: Infection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infections in patients with AA. Secondary objectives were to evaluate overall survival after infections as well as risk factors of infections in patients with AA. Read More
Int J Microbiol 2018 11;2018:3912326. Epub 2018 Nov 11.
Department of Microbiology, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia.
colonizing gastrointestinal and urogenital tracts of humans and animals is widely used in manufacturing of fermented products and as probiotics. These bacteria may function as vehicles of antibiotic resistance genes, which can be transferred to pathogenic bacteria. Therefore, monitoring and control of transmissible antibiotic resistance determinants in these microorganisms is necessary to approve their safety status. Read More
Front Microbiol 2018 26;9:2803. Epub 2018 Nov 26.
State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China.
The intra-aggregate architecture of soil macroaggregates provides suitable microhabitats for nematodes to graze on microorganisms. However, it is not fully clear how nematodes and microbial communities interactively mediate soil organic carbon (SOC) turnover. Here, we aimed to illustrate the relationships between nematodes, microbial community, and SOC turnover in the macroaggregates of a red soil receiving long-term manure application. Read More
Microbiol Resour Announc 2018 Aug 23;7(7). Epub 2018 Aug 23.
College of Science and Technology, Bellevue University, Bellevue, Nebraska, USA.
Rhodovulum is a marine Gram-negative purple photosynthetic bacterial genus that is a member of the . Strain BSW8 is a variant that does not appear to make a polysaccharide slime capsule, and its genome sequence further contributes to the diversity of sequenced genomes belonging to this genus. Read More
Microbiol Resour Announc 2018 Aug 23;7(7). Epub 2018 Aug 23.
Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany.
Streptomyces sp. strain SW4 exhibited broad-spectrum antibacterial activity toward Gram-positive and Gram-negative pathogens. The 7. Read More
Microbiol Resour Announc 2018 Nov 29;7(21). Epub 2018 Nov 29.
Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland, USA.
Shigella is a genus of Gram-negative enteric pathogenic bacteria which has four species, Shigella dysenteriae, S. flexneri, S. boydii, and S. Read More
Microbiol Resour Announc 2018 Nov 29;7(21). Epub 2018 Nov 29.
King Abdullah International Medical Research Center, Infectious Diseases Research Department, Riyadh, Saudi Arabia.
The intracellular Gram-negative bacterium Brucella melitensis causes a zoonotic disease in humans originating from animals. Here, we report the whole-genome sequence (WGS) of Brucella melitensis strain KSA_BM_07, isolated from sheep in March 2017 in Huraymila, Kingdom of Saudi Arabia. Read More
Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.
Pathobiology Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.
Klebsiella pneumoniae is a Gram-negative bacterium that may cause infection in a broad range of hosts. We report here the genome sequences of seven K. pneumoniae isolates from New Zealand sea lions. Read More
Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.
Wildbase, School of Veterinary Science, Massey University, Palmerston North, New Zealand.
Klebsiella pneumoniae is a Gram-negative bacterium that can be found in the environment, as well as on mucosal surfaces of humans and animals. Here, we report the genome sequence of five K. pneumoniae isolates from substrate samples and bird feces collected in the Subantarctic Islands of New Zealand. Read More
Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.
Biology Program, University of New Hampshire, Manchester, New Hampshire, USA.
The Gram-negative genus Kangiella contains a number of halophilic species that display high levels of iso-branched fatty acids. Kangiella spongicola was isolated from a marine sponge, Chondrilla nucula, from the Florida Keys in the United States. A genome assembly of 2,825,399 bp with a 44. Read More
Microbiol Resour Announc 2018 Nov 15;7(19). Epub 2018 Nov 15.
Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Klebsiella pneumoniae is a Gram-negative bacterium associated with the gastrointestinal tract and is a significant nosocomial pathogen due to its antibiotic resistance. Phage therapy against K. pneumoniae may prove useful in treating infections caused by this bacterium. Read More
Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.
Biological Assessment and Standardization Section, Environment and Climate Change Canada, Ottawa, Ontario, Canada.
Pseudomonas fluorescens is a Gram-negative bacterium with versatile metabolic functions and potential industrial uses. We sequenced P. fluorescens strain ATCC 13525 with the goal of determining virulence factors and antibiotic resistance genes to predict the potential impacts on human and environmental health in the event of exposure. Read More
Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.
School of Marine Sciences, Ningbo University, Ningbo, China.
Pseudomonas plecoglossicida is a Gram-negative fish pathogen responsible for visceral granular disease in large yellow croaker, . Here, we report the complete genome sequence of a verified virulent strain, XSDHY-P, that was isolated from spleen tissue of a diseased large yellow croaker. Read More
Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.
Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses (IBIZ), Jena, Germany.
Here, we report the draft genome sequence of Taylorella equigenitalis strain 210217RC10635, a Gram-negative bacterium belonging to the genus Taylorella and the order Burkholderiales. Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM). The strain reported here was isolated in 2017 from a German stallion. Read More
Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.
Department of Pharmaceutical Biology, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany.
Pseudomonas aeruginosa TUEPA7472 is extensively drug resistant (XDR) and is a representative Gram-negative rod that is multiresistant toward 4 classes of clinically relevant antibiotics (4MRGN). The 6.8-Mb draft genome sequence of this strain provides insight into these resistance mechanisms and the potential of the strain to produce virulence factors. Read More
Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.
College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
Pasteurella multocida is an animal-associated Gram-negative member of the Pasteurellaceae family. It is an opportunistic pathogen and is one of the principal bacterial species contributing to bovine respiratory disease complex (BRDC) in feedlot cattle. We present 16 closed genome sequences and antibiograms of isolates cultured from calves exhibiting clinical signs of BRDC and from control calves not showing signs of BRDC. Read More
Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.
Fuels and Energy Branch, Aerospace Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Ohio, USA.
Achromobacter spanius strain 6 is a Gram-negative soil bacterium isolated from a hydrocarbon-degrading microcosm. The draft genome sequence of A. spanius strain 6 is 6. Read More
Mycology 2018 31;9(4):264-272. Epub 2018 May 31.
School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
Forty-four endophytes were isolated from and identified morphologically. The ethyl acetate extracts of all endophytes were obtained. The ethyl acetate extracts were subjected to study antibacterial and antioxidant activities. Read More
PLoS One 2018 11;13(12):e0208769. Epub 2018 Dec 11.
Biology Department, Dakota State University, Madison, South Dakota, United States of America.
Laboratory science requires careful maintenance of sterile reagents and tools as well as the sterilization of waste prior to disposal. However, steam autoclaves typically used for this purpose may not be readily accessible to everyone in the scientific community, such as K-12 teachers, researchers in the field, students in under-funded laboratories, or persons in the developing world who lack funding and resources. This work examines the use of commercial electric pressure cookers as an alternative method for the sterilization of media, instruments, and waste. Read More
Int J Microbiol 2018 4;2018:6475072. Epub 2018 Nov 4.
Department of Plant Biotechnology, National Research Centre (NRC), Cairo 12622, Egypt.
The discovery of novel and more efficient antimicrobial agents from natural sources like plants is one of the most important ways through which the growing threat of antibiotic-resistant pathogens can be overcome. Herein, we report the potential antimicrobial activity of L. subsp. Read More
Front Microbiol 2018 23;9:2864. Epub 2018 Nov 23.
Clinical Microbiology and Bioactive Screening Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India.
Nosocomial infections caused by antibiotic-resistant Gram-negative pathogens are of grave concern today. Polymyxins are considered as the last resorts of therapy to treat these multi-drug resistant (MDR) bacteria. But their associated nephrotoxicity and neurotoxicity calls for the development of safer polymyxin therapy until novel and less toxic antibiotics are discovered. Read More
Front Microbiol 2018 23;9:2810. Epub 2018 Nov 23.
Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Outer membrane vesicles (OMVs) are spherical membranous structures released by Gram-negative bacteria. Several bacterial pathogens utilize OMVs as vehicles for the delivery of virulence factors into host cells. Results of our previous study on proteomic analysis revealed that OMVs isolated from serovar Typhimurium had virulence effectors that are known to be translocated by pathogenicity island 1 (SPI-1)-encoded type III secretion system (T3SS1) into the host cell. Read More
Saudi Pharm J 2018 Dec 31;26(8):1089-1097. Epub 2018 May 31.
Faculty of Science, Al-Baha University, Baha, Saudi Arabia.
In recent years, the decreased efficacy of existing antibiotics toward management of emergent drug-resistant strains has necessitated the search for novel antibiotics from natural products. In this regard, sp is well known for producing variety of secondary metabolites of potential use. Therefore, we performed an investigation to isolate and identify sp from oral cavity for production of novel antimicrobial compounds. Read More
Infect Drug Resist 2018 15;11:2311-2319. Epub 2018 Nov 15.
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China,
Objective: This study aimed to determine the risk factors for intra-abdominal infections (IAIs), assess the clinical outcomes of IAIs, and investigate the spectrum and antimicrobial resistance of major pathogens causing IAIs.
Patients And Methods: This prospective observational study enrolled patients from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) program between 2007 and 2016. Data on the clinicopathological factors and causative pathogens were collected. Read More
Int J Nanomedicine 2018 15;13:7565-7574. Epub 2018 Nov 15.
Micro & Nanomédecines Translationelles-MINT, UNIV Angers, INSERM U1066, CNRS UMR 6021, UBL Universite Bretagne Loire, Angers, France.
Introduction: Resistance to traditional antibiotics is an increasingly serious problem. Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential against infectious diseases, as they are less prone to induce resistance. Nanotechnology-based delivery strategies can improve the efficiency and stability of AMPs, particularly against proteolytic degradation. Read More
Nat Commun 2018 12 7;9(1):5231. Epub 2018 Dec 7.
Department of Chemistry and Biochemistry, Columbia, SC, 29208, United States.
Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to enhance interactions with bacterial membranes without requiring a globally conformational arrangement associated with highly unfavorable entropic loss. This concept of macromolecular architectures is demonstrated with a series of multicyclic natural product-based cationic polymers. Read More