- Mariusz Z Ratajczak,
- Mateusz Adamiak,
- Magda Kucia,
- William Tse,
- Janina Ratajczak,
- Wieslaw Wiktor-Jedrzejczak
Front Immunol 2018 5;9:1295. Epub 2018 Jun 5.
Department of Hematology Warsaw Medical University, Warsaw, Poland.
Innate immunity plays an important role in orchestrating the immune response, and the complement cascade (ComC) is a major component of this ancient defense system, which is activated by the classical-, alternative-, or mannan-binding lectin (MBL) pathways. However, the MBL-dependent ComC-activation pathway has been somewhat underappreciated for many years; recent evidence indicates that it plays a crucial role in regulating the trafficking of hematopoietic stem/progenitor cells (HSPCs) by promoting their egress from bone marrow (BM) into peripheral blood (PB). This process is initiated by the release of danger-associated molecular patterns (DAMPs) from BM cells, including the most abundant member of this family, adenosine triphosphate (ATP). Read More