306,929 results match your criteria Graft Versus Host Disease


Nerve grafting for peripheral nerve injuries with extended defect sizes.

Wien Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Artificial and non-artificial nerve grafts are the gold standard in peripheral nerve reconstruction in cases with extensive loss of nerve tissue, particularly where a direct end-to-end suture or an autologous nerve graft is inauspicious. Different materials are marketed and approved by the US Food and Drug Administration (FDA) for peripheral nerve graft reconstruction. The most frequently used materials are collagen and poly(DL-lactide-ε-caprolactone). Read More

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December 2018

Explantation of infected thoracic endovascular aortic repair.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):307-310. Epub 2018 Dec 4.

Division of Vascular and Endovascular Surgery, University of Massachusetts Medical School, Worcester, Mass.

Prosthetic graft infection is a rare and serious complication of thoracic endovascular aortic repair associated with high mortality and posing unique challenges for treatment. The prosthetic graft infection is often identified late as patients present with mild nonspecific symptoms. We describe the successful medical management and surgical explantation of an infected thoracic endograft with an aorta-bronchial fistula, using an inline reconstruction with an antibiotic-soaked synthetic graft. Read More

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December 2018

Aortic treatment of native infection by reconstruction with the Omniflow II biologic prosthesis.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):296-300. Epub 2018 Dec 4.

Department of Thoracic and Cardiovascular Surgery, Trousseau University Hospital, Tours, France.

Aortic infection is a challenging condition. Fortunately, surgical revision of infected aorta with in situ reconstruction can provide long-term cure. The material for aortic repair remains an area of debate. Read More

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December 2018

Repair of a symptomatic true radial artery aneurysm at the anatomic snuff box with interposition great saphenous vein graft.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):292-295. Epub 2018 Dec 4.

Division of Vascular Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.

Radial artery aneurysms are exceedingly rare, with only a few reported cases of surgical revascularization. We describe a 25-year-old man who presented with severe ischemia of the right hand secondary to an idiopathic true radial artery aneurysm at the anatomic snuff box. The patient had embolic occlusions in his hand and fingers that were treated with catheter-directed thrombolysis. Read More

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December 2018

Aneurysmal degeneration and rupture of deep vein conduit with formation of an arterial-vaginal fistula 13 years after creation of a femoral-femoral bypass.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):287-291. Epub 2018 Dec 4.

Department of Surgery, UT Southwestern Medical Center, Dallas, Tex.

The autologous deep vein is a suitable alternative to prosthetic or cadaveric grafts as a bypass conduit because of its superior durability and lower risk of complications. Aneurysmal degeneration of deep vein grafts is rarely seen but can potentially be fatal when it does occur. We describe the case of an 87-year-old woman who presented with acute vaginal bleeding due to the rupture of an aneurysmal femorofemoral bypass vein graft into the vagina. Read More

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December 2018

Minimally invasive treatment of vascular complications after neoaortoiliac system reconstruction using autologous vein grafts.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):283-286. Epub 2018 Dec 4.

Department of Vascular Surgery, Leiden University Medical Center, Leiden, the Netherlands.

Treatment of complications after neoaortoiliac system vein reconstruction is a complex clinical problem with poor results. Endovascular treatment might offer an acceptable outcome in selected cases. We report two rare complications after neoaortoiliac system vein reconstruction for an infected aortic graft. Read More

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December 2018

Do Tibial Eminence Fractures and Anterior Cruciate Ligament Tears Have Similar Outcomes?

Orthop J Sports Med 2018 Dec 7;6(12):2325967118811854. Epub 2018 Dec 7.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Avulsion fractures involving the tibial eminence are considered equivalent in terms of the cause to anterior cruciate ligament (ACL) tears; however, there are limited data comparing the outcomes of adolescent patients undergoing surgical fixation of a tibial eminence fracture (TEF) with those undergoing ACL reconstruction.

Purpose: To compare the clinical outcomes, subsequent ACL injury rates, and activity levels between adolescent patients who underwent TEF fixation with patients with midsubstance ACL tears who required acute reconstruction.

Study Design: Cohort study; Level of evidence, 3. Read More

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December 2018

Effects of Remnant Tissue Preservation on Tunnel Enlargement After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using the Hamstring Tendon.

Orthop J Sports Med 2018 Dec 6;6(12):2325967118811293. Epub 2018 Dec 6.

Sports Medicine and Arthroscopy Center, Yagi Orthopaedic Hospital, Sapporo, Japan.

Background: The effects of remnant tissue preservation on tunnel enlargement after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction have not yet been established.

Hypothesis: The preservation of ACL remnant tissue may significantly reduce the degree and incidence of tunnel enlargement after anatomic double-bundle ACL reconstruction, while the remnant-preserving procedure may not significantly increase the incidence of tunnel coalition after surgery.

Study Design: Cohort study; Level of evidence, 2. Read More

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December 2018

Ameloblastoma: Management and Outcome.

Cureus 2018 Oct 10;10(10):e3437. Epub 2018 Oct 10.

Otolaryngology, Aga Khan University Hospital, Karachi, PAK.

Introduction Ameloblastoma is a locally destructive tumor with a propensity for recurrence if not entirely excised. Management of ameloblastoma poses a challenge for all involved in the field of head and neck surgery because successful treatment requires not only adequate resection but also a functional and aesthetically acceptable reconstruction of the residual defect. Methods Patients who had histologically proven ameloblastoma between 1991 and 2009 were identified from the database of Aga Khan University Hospital. Read More

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October 2018

Evaluation of the relative efficacy of autologous platelet-rich fibrin membrane in combination with β-tricalcium phosphate (Septodont- resorbable tissue replacement)™ alloplast versus β-TCP alloplast alone in the treatment of grade II furcation defects.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):196-204

Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.

Introduction: Platelet-rich fibrin (PRF) is considered as the second-generation platelet concentrate, contains combined properties of fibrin, platelets, leukocytes, growth factors, and cytokines that make it as healing biomaterial with incredible potential for hard tissue and soft tissue regeneration. The present study was aimed to evaluate the effectiveness of PRF with β-tricalcium phosphate (β-TCP) graft (R. T. Read More

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December 2018

Use of plasma-enriched demineralized freeze-dried bone matrix in postsurgical jaw defects.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):174-183

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, IMS, BHU, Varanasi, Uttar Pradesh, India.

Aim And Objectives: The aim is to know the augmented new bone formation in postsurgical bony defects in the maxillofacial region when filled with plasma-enriched demineralized freeze-dried bone allograft (DFDBA).

Materials And Methods: The study group included 45 patients, selected randomly, and divided in three equated groups. In Group I (control) patients, the wound was closed primarily without incorporating any graft in the bony defect. Read More

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December 2018

A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia-lymphoma.

Bone Marrow Transplant 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.

Currently, allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only available curative modality for patients with adult T-cell leukemia-lymphoma (ATL). When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sources, especially cord blood and conventional HLA haplo-identical donors, are needed to validate the safety and efficacy of this modality. Read More

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December 2018
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Healthcare Resource Use, Cost, and Sick Leave Following Kidney Transplantation in Sweden: A Population-Based, 5-Year, Retrospective Study of Outcomes: COIN.

Ann Transplant 2018 Dec 14;23:852-866. Epub 2018 Dec 14.

Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden.

BACKGROUND Improved understanding of the impact of kidney transplantation on healthcare resource use/costs and loss of productivity could aid decision making about funding allocation and resources needed for the treatment of chronic kidney disease in stage 5. MATERIAL AND METHODS This was a retrospective study utilizing data from Swedish national health registers of patients undergoing kidney transplantation. Primary outcomes were renal disease-related healthcare resource utilization and costs during the 5 years after transplantation. Read More

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December 2018

Intensive care, right ventricular support and lung transplantation in patients with pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Intensive care of patients with pulmonary hypertension (PH) and right-sided heart failure includes treatment of factors causing or contributing to heart failure, careful fluid management, and strategies to reduce ventricular afterload and improve cardiac function. Extracorporeal membrane oxygenation (ECMO) should be considered in distinct situations, especially in candidates for lung transplantation (bridge to transplant) or, occasionally, in patients with a reversible cause of right-sided heart failure (bridge to recovery). ECMO should not be used in patients with end-stage disease without a realistic chance for recovery or for transplantation. Read More

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December 2018

The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels.

J Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, 03550 San Juan de Alicante, Spain

TRPM8 is a polymodal, non-selective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, including the treatment of organ rejection following transplants, treatment of atopic dermatitis and dry eye disease. Tacrolimus is an inhibitor of the phosphatase calcineurin, an action shared with cyclosporine. Read More

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December 2018
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Ossicular chain reconstruction in chronic otitis media: hearing results and analysis of prognostic factors.

Braz J Otorhinolaryngol 2018 Oct 18. Epub 2018 Oct 18.

Hospital Governador Celso Ramos, Departamento de Otorrinolaringologia, Florianópolis, SC, Brazil.

Introduction: The goal of ossiculoplasty is to improve hearing and the success of this procedure depends on several factors.

Objective: Analyze the hearing results in patients with chronic otitis media undergoing ossicular chain reconstruction, as well as predictive factors for successful surgery.

Methods: Charts of patients undergoing ossiculoplasty between 2006 and 2016 were reviewed. Read More

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October 2018

Coexisting hypogastric aneurysms worsen the outcomes of endovascular treatment by the iliac branch devices within the pELVIS Registry.

J Vasc Surg 2018 Dec 10. Epub 2018 Dec 10.

New York University, New York, NY.

Objective: Hypogastric aneurysms (HAs) frequently coexist with aortoiliac aneurysms (AIAs). However, the presence of an HA is a contraindication to endovascular aneurysm treatment by iliac branch devices (IBDs) because of the risk of distal sealing-related endoleaks. No robust evidence exists in the published literature, and therefore we sought to evaluate the performance of IBDs in the presence of HAs within a multicenter registry of nine vascular centers. Read More

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December 2018

Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease.

Cell Immunol 2018 Dec 4. Epub 2018 Dec 4.

School of Biological Sciences, University of Wollongong, Wollongong, NSW 2252, Australia; Molecular Horizons, University of Wollongong, NSW 2252, Australia; Illawarra Health and Medical Research Institute, Wollongong, NSW 2252, Australia. Electronic address:

Allogeneic haematopoietic stem cell transplantation (HSCT) is a frequent curative therapy for numerous haematological malignancies. However, HSCT is limited by the occurrence of graft-versus-host disease (GVHD), with current therapies restricted to general immunosuppression. Activation of the P2X7 receptor by extracellular adenosine triphosphate (ATP) causes inflammation and tissue damage in GVHD. Read More

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December 2018

Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports.

J Med Case Rep 2018 Dec 14;12(1):368. Epub 2018 Dec 14.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Introduction: Acquired partial lipoatrophy has been reported after bone marrow transplantation during childhood; however, no adult cases have previously been reported. We herein report two adult cases of acquired partial lipoatrophy after transplantation.

Case Presentation: A 28-year-old Japanese woman developed diabetic ketoacidosis and received insulin therapy after bone marrow transplantation. Read More

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December 2018
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Hamstring Injuries in Major League Baseball Pitchers: Implications in Graft Selection for Ulnar Collateral Ligament Reconstruction.

Am J Sports Med 2018 Dec 13:363546518815689. Epub 2018 Dec 13.

Kerlan-Jobe Orthopaedic Clinic, Los Angeles, California, USA.

Background:: Hamstring tendons are commonly harvested as autograft for ulnar collateral ligament reconstruction. There is no consensus in the literature whether the hamstring tendon should be harvested from the ipsilateral (drive) leg or contralateral (landing) leg of baseball pitchers undergoing ulnar collateral ligament reconstruction. Hamstring injuries commonly occur in baseball players, but there are no reports on their incidence specifically among Major League Baseball (MLB) pitchers, nor are there reports on whether they occur more commonly in the drive leg or the landing leg. Read More

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December 2018

The Option of Motion Preservation in Cervical Spondylosis: Cervical Disc Arthroplasty Update.

Neurospine 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.

Cervical disc arthroplasty (CDA), or total disc replacement, has emerged as an option in the past two decades for the management of 1- and 2-level cervical disc herniation and spondylosis causing radiculopathy, myelopathy, or both. Multiple prospective randomized controlled trials have demonstrated CDA to be as safe and effective as anterior cervical discectomy and fusion, which has been the standard of care for decades. Moreover, CDA successfully preserved segmental mobility in the majority of surgical levels for 5-10 years. Read More

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December 2018

Neurological and Inflammatory Manifestations in Sjögren's Syndrome: The Role of the Kynurenine Metabolic Pathway.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Ribeirao Preto Medical School, Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049-900 Brazil.

For decades, neurological, psychological, and cognitive alterations, as well as other glandular manifestations (EGM), have been described and are being considered to be part of Sjögren's syndrome (SS). Dry eye and dry mouth are major findings in SS. The lacrimal glands (LG), ocular surface (OS), and salivary glands (SG) are linked to the central nervous system (CNS) at the brainstem and hippocampus. Read More

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December 2018

The Cytomegalovirus-Specific IL-21 ELISpot Correlates with Allograft Function of Kidney Transplant Recipients.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Department of Nephrology, University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany.

In kidney transplant recipients, the cytomegalovirus (CMV) is frequently causing infection/reactivation and can trigger allograft rejection. To assess the risk of reactivation, the cellular immune response against CMV is increasingly assessed by cellular in vitro methods, such as the interferon (IFN)-γ ELISpot. In the current study we compared the IFN-γ ELISpot with our newly established CMV-specific ELISpot assays determining IL-17A, IL-21, IL-22, granzyme B, and perforin and correlated the results with flow cytometric data and clinical parameters. Read More

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December 2018

Thoracic endovascular repair technique for the treatment of patent ductus arteriosus in an elderly patient: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13558

Department of Thoracic and Cardiovascular surgery, College of Medicine, Yeungnam University, Daegu, Korea.

Rationale: Patent ductus arteriosus (PDA) ligation by open surgery is more difficult and dangerous in elderly patients than in infants. Nowadays, simple and safe interventional catheterization technology is used for the closure of uncomplicated isolated PDAs. Therefore, an alternative less invasive therapeutic option must be developed to treat complicated PDA. Read More

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December 2018

Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13487

Division of Infection Control and Prevention, Osaka University Hospital.

Rationale: Daptomycin (DAP) is a key drug for treating severe Staphylococcus infections. The emergence of DAP non-susceptible Staphylococcus aureus has been widely recognized in clinical situations, although the clinical status of DAP non-susceptible coagulase-negative Staphylococcus (CoNS) infections is unclear. We encountered 2 cases of cardiovascular device infections that were associated with DAP non-susceptible CoNS. Read More

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December 2018

Quality of life of patients with a colonic interposition postoesophagectomy.

Eur J Cardiothorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastro-Intestinal Surgery, Ghent University Hospital, Ghent, Belgium.

Objectives: After oesophagectomy, stomach grafts are most frequently used to restore intestinal continuity. Less frequently, a colonic graft is used. There is quite a large body of literature addressing the functional outcome after gastric pull-up, but little is known about the functional results of colonic interposition (CI). Read More

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December 2018

Post-sternotomy deep wound infection following aortic surgery: wound care strategies to prevent prosthetic graft replacement.

Eur J Cardiothorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: The aim of this study was to evaluate the early and long-term outcomes of our multidisciplinary strategy for treating deep sternal wound infection after aortic grafting, which consisted of debridement by a plastic surgeon, negative pressure wound therapy with continuous irrigation and chest wall reconstruction.

Methods: We performed a retrospective analysis of 18 patients who had a deep sternal wound infection following aortic grafting through a median sternotomy between January 2009 and December 2017. All patients had organisms cultured from mediastinal tissue within 2 months from the initial aortic surgery. Read More

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December 2018

Gender Disparities in Vascular Access Surgical Outcomes in Elderly Hemodialysis Patients.

Am J Nephrol 2018 Dec 13;49(1):11-19. Epub 2018 Dec 13.

Division of Nephrology, Department of Medicine, University of Alabama at, Birmingham, Alabama, USA.

Background: Despite national vascular access guidelines promoting the use of arteriovenous fistulas (AVF) over arteriovenous grafts (AVGs) for dialysis, AVF use is substantially lower in females. We assessed clinically relevant AVF and AVG surgical outcomes in elderly male and female patients initiating hemodialysis with a central venous catheter (CVC).

Methods: Using the United States Renal Data System standard analytic files linked with Medicare claims, we assessed incident hemodialysis patients in the United States, 9,458 elderly patients (≥67 years; 4,927 males and 4,531 females) initiating hemodialysis from July 2010 to June 2011 with a catheter and had an AVF or AVG placed within 6 months. Read More

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December 2018

Total arch replacement for aortic arch aneurysm with coexisting middle aortic syndrome.

Int J Surg Case Rep 2018 Nov 24;54:79-82. Epub 2018 Nov 24.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan. Electronic address:

Introduction: Middle aortic syndrome (MAS) combined with thoracic aortic aneurysm (TAA) is a rare vascular disease. One stage open surgery to treat this condition, becomes a challenge for our cardiovascular surgery.

Presentation Of Case: A 69-year-old man presented with a saccular type aortic arch aneurysm, shaggy aorta and severe atherosclerotic stenosis of the thoracoabdominal aorta with middle aortic syndrome and aberrant right subclavian artery, renovascular hypertension, renal dysfunction, and intermittent claudication of both legs. Read More

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November 2018

Effects of recombinant thrombomodulin therapy and soluble human leukocyte antigen-G levels during hematopoietic stem cell transplantation.

Transpl Immunol 2018 Dec 10. Epub 2018 Dec 10.

Kansai Medical University, Japan.

Background: Conditioning chemotherapies for hematopoietic stem cell transplantation (HSCT), especially those that include total body irradiation, can result in serious complications such as graft-versus-host disease (GVHD). Human leukocyte antigen G (HLA-G) is a non-classical class I molecule with multiple immunoregulatory functions.

Methods: We measured interleukin (IL)-10, transforming growth factor (TGF)β, and soluble HLA-G (sHLA-G) in HSCT patients and examined the relationship between sHLA-G levels and acute GVHD (aGVHD). Read More

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December 2018

The prevention of tracheal graft occlusion using pioglitazone: A mouse tracheal transplant model study.

Transpl Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Bronchiolitis obliterans (BO), which begins with lymphocytic bronchiolitis (LB), is the most serious manifestations of chronic rejection following lung transplantation. We have evaluated the effects of intraperitoneal administration of pioglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist, on LB in mice tracheal transplant model. Tracheal grafts from BALB/c or C57BL/6 were transplanted to C57BL/6 recipients. Read More

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December 2018

Bone Marrow Aspirate Concentrate Does Not Improve Osseous Integration of Osteochondral Allografts for the Treatment of Chondral Defects in the Knee at 6 and 12 Months: A Comparative Magnetic Resonance Imaging Analysis.

Am J Sports Med 2018 Dec 13:363546518813915. Epub 2018 Dec 13.

Sports Medicine Service, Hospital for Special Surgery, New York, New York, USA.

Background:: Poor osseous integration after fresh osteochondral allograft transplantation (OCA) may be associated with graft subsidence and subchondral bone collapse after implantation. The augmentation of OCA with bone marrow aspirate concentrate (BMAC) has been hypothesized to improve osseous incorporation of the implanted allograft.

Purpose:: To evaluate the effect of autogenous BMAC treatment on osseous integration at the graft-host bony interface after OCA. Read More

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December 2018

Application of Enamel Matrix Derivative and Intrusive Orthodontic Movement in the Treatment of Vertical Bony Defects: A Case Report.

Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):73-81

This case report presents treatment of a severe localized horizontal bone loss combined with infrabony defects adjacent to pathologically migrated teeth by orthodontic intrusion following a graft of enamel matrix derivative (EMD) without root surface conditioning. The patient was diagnosed with Angle Class II malocclusion, anterior spacing, and pathologically migrated incisors. Graft of EMD mixed with bone materials was applied for periodontal regeneration before orthodontic treatment, and periapical radiographs were taken every 3 months for radiographic evaluation. Read More

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December 2018

Decreased preoperative functional status is associated with increased mortality following coronary artery bypass graft surgery.

PLoS One 2018 13;13(12):e0207883. Epub 2018 Dec 13.

Brigham and Women's Hospital, The Nathan E. Hellman Memorial Laboratory, Renal Division, Channing Division of Network Medicine, Department of Medicine, Boston, Massachusetts, United States of America.

Objectives: Functional status prior to coronary artery bypass graft surgery may be a risk factor for post-operative adverse events. We sought to examine the association between functional status in the 3 months prior to coronary artery bypass graft surgery and subsequent 180 day mortality.

Design, Setting, And Participants: We performed a single center retrospective cohort study in 718 adults who received coronary artery bypass graft surgery from 2002 to 2014. Read More

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December 2018

Supervised physiotherapy leads to a better return to physical activity after anterior cruciate ligament reconstruction.

J Sports Med Phys Fitness 2018 Dec 13. Epub 2018 Dec 13.

Intensive Cardiac Therapy Clinic, Department of Invasive Cardiology and Electrocardiology, Medical University, Lodz, Poland.

Background: The main goal of rehabilitation after anterior cruciate ligament reconstruction (ACLR) is to return to functional and sports activity at a preinjury level. The aim of this study was to assess the influence of supervised (SU) versus non-supervised (NS) rehabilitation protocols after ACLR on the return to sports activity and quality of life of amateur athletes.

Methods: The study included a total of 50 patients after ACLR, with 25 in the SU group and 25 in the NS group. Read More

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December 2018

Investigation of the effect of combined use of alloplastic-based tricalcium phosphate bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically induced bone defects in nondiabetic rats: an experimental animal study

Turk J Med Sci 2018 12 12;48(6):1302-1314. Epub 2018 Dec 12.

Department of Histology and Embryology, Faculty of Medicine, Dicle University Diyarbakir, Turkey

Background/aim: In this experimental study, we aimed to evaluate the late period effects of the combination of Ankaferd Blood Stopper (ABS), which has bone wound healing effects, and β-tricalcium phosphate (TCP) on the regeneration of bone tissue through histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats.

Materials And Methods: Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7. Read More

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December 2018

A Grafting Technique for Efficiently Transplanting Transgenic Regenerated Plants of Cotton.

Methods Mol Biol 2019 ;1902:195-198

Department of Biology, East Carolina University, Greenville, NC, USA.

Recovery of transgenic cotton plants from tissue culture condition to greenhouse condition is a critical step for improving cotton through genetic engineering. Traditional methods always cause low survival rate of transplanted plants. In 1998, we developed an efficient grafting technique for recovery of transgenic cotton plants, which significantly increased the survival rate of the transplanting regeneration plants. Read More

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January 2019

Hematopoietic Stem Cell Transplantation in Patients with Heterozygous STAT1 Gain-of-Function Mutation.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Division of Pediatric Allergy/Immunology, Marmara University, Fevzi Çakmak Mah. No: 41, Pendik, Istanbul, Turkey.

Purpose: Human signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations present with a broad range of manifestations ranging from chronic mucocutaneous candidiasis and autoimmunity to combined immunodeficiency (CID). So far, there is very limited experience with hematopoietic stem cell transplantation (HSCT) as a therapeutic modality in this disorder. Here, we describe two patients with heterozygous STAT1 GOF mutations mimicking CID who were treated with HSCT. Read More

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December 2018

Cyclosporine levels > 195 μg/L on day 10 post-transplant was associated with significantly reduced acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.

Ann Hematol 2018 Dec 12. Epub 2018 Dec 12.

Division of Hematology, Department of Medicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Acute graft-versus-host disease (aGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Prophylaxis with cyclosporine A (CsA) is the backbone of GvHD prevention. In a retrospective analysis of patients treated with allo-HSCT, we correlated CsA levels on the day of transplantation (day 0) and on day + 10 with the incidence of acute and chronic GvHD. Read More

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December 2018

Donor site complications following anterior iliac crest bone graft for treatment of distal radius fractures.

Arch Orthop Trauma Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Anesthesiology and Operative Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Introduction: In distal radius fractures with metaphyseal comminution, bone grafting or the use of a bone substitute may be necessary. Harvesting autologous iliac crest bone graft for other orthopedic procedures has complications. The aim of this study was to evaluate the complication rate after harvesting a small amount of bone as used for the treatment of radius fractures. Read More

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December 2018

Single-Incision Double-Plating Approach in the Management of Isolated, Closed Osteoporotic Distal Femoral Fractures.

Geriatr Orthop Surg Rehabil 2018 11;9:2151459318799856. Epub 2018 Nov 11.

Ain-Shams University, Cairo, Egypt.

Introduction: Distal femoral fractures in elderly population had recorded an increase in incidence in the last 2 decades. Lateral distal femoral locking plating is considered one of the best options especially when dealing with comminuted fractures but varus collapse of the medial femoral condyle occurs frequently in patients with osteoporosis. Anatomical reduction of the fracture with stable rigid fixation using double-plating approach allows early mobilization of geriatric population and prevents varus collapse minimizing the comorbidities in such fractures. Read More

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November 2018

Transfusion-associated graft-versus-host disease: A concise review.

Authors:
Palma Manduzio

Hematol Rep 2018 Nov 6;10(4):7724. Epub 2018 Nov 6.

Diagnostic Department, Clinical Pathology, 'Augusto Murri' Civil Hospital of Fermo, Italy.

Transfusion-associated graft-versushost disease (TA-GVHD) represents a rare fatal event observed in immunocompromised patients and immunocompetent individuals. The main clinical features of this transfusion reaction are pancitopenia and multiorgan failure (skin, liver, gut). The possible pathogenesis includes donor T lymphocyte proliferation in blood, their engraftment and host tissue attack. Read More

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November 2018

Osteofibrous dysplasia arising in the humerus: A case report.

Rare Tumors 2018 5;10:2036361318808852. Epub 2018 Nov 5.

Department of Pathology, Tohoku University Hospital, Sendai, Japan.

Osteofibrous dysplasia is a benign fibro-osseous lesion of bone which is most commonly occurred in cortical bone of anterior mid-shaft of the tibia of infancy and childhood. This study reported a case of osteofibrous dysplasia arising in the humerus of adult, resulting in good prognosis after a surgical treatment. A 34-year-old male had felt left upper arm pain and was suspected as having a bone tumor at the humeral shaft by X-ray pictures. Read More

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November 2018

Factors Produced by Macrophages Eliminating Apoptotic Cells Demonstrate Pro-Resolutive Properties and Terminate Ongoing Inflammation.

Front Immunol 2018 13;9:2586. Epub 2018 Nov 13.

INSERM, EFS Bourgogne Franche-Comté, UMR1098, Interactions Hôte-Greffon-Tumeur, LabEX LipSTIC, FHU INCREASE, Université Bourgogne Franche-Comté, Besançon, France.

Unresolved inflammation is a common feature in the pathogenesis of chronic inflammatory/autoimmune diseases. The factors produced by macrophages eliminating apoptotic cells during resolution are crucial to terminate inflammation, and for subsequent tissue healing. We demonstrated here that the factors produced by macrophages eliminating apoptotic cells were sufficient to reboot the resolution of inflammation , and thus definitively terminated ongoing chronic inflammation. Read More

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November 2018

The histopathological effects of calcium triglyceride bone cement and chitosan on the healing of experimental bone defects

Turk J Med Sci 2018 12 12;48(6):1268-1277. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, İstanbul University, İstanbul, Turkey

Background/aim: This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement (CTBC) and chitosan, on the healing of experimental bone defects.

Materials And Methods: Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. Read More

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December 2018

Strategies for Targeted Delivery to the Peripheral Nerve.

Front Neurosci 2018 27;12:887. Epub 2018 Nov 27.

Audie L. Murphy VA Hospital, San Antonio, TX, United States.

Delivery of compounds to the peripheral nervous system has the potential to be used as a treatment for a broad range of conditions and applications, including neuropathic pain, regional anesthesia, traumatic nerve injury, and inherited and inflammatory neuropathies. However, efficient delivery of therapeutic doses can be difficult to achieve due to peripheral neuroanatomy and the restrictiveness of the blood-nerve barrier. Depending on the underlying integrity of the blood-nerve barrier in the application at hand, several strategies can be employed to navigate the peripheral nerve architecture and facilitate targeted delivery to the peripheral nerve. Read More

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November 2018

Anterolateral Complex Reconstruction: Another Fad or Method to Improve ACL Outcomes?

Tech Orthop 2018 Dec 25;33(4):239-245. Epub 2017 Dec 25.

The Fowler Kennedy Sport Medicine Clinic.

Anterolateral rotational laxity of the knee is a persistent problem following anterior cruciate ligament reconstruction (ACLR) that can lead to increased rates of graft failure. Renewed interest in the anterolateral complex of the knee has led to a resurgence in the use of adjunctive techniques such as lateral extra-articular tenodesis and anterolateral ligament reconstruction. Use of these techniques can restore normal knee kinematics and potentially thereby reduce the rate of graft failure. Read More

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December 2018

Clinical Results of Lateral Extra-Articular Tenodesis.

Tech Orthop 2018 Dec 25;33(4):232-238. Epub 2017 Dec 25.

Melbourne Orthopaedic Group, Windsor, Vic., Australia.

In the anterior cruciate ligament (ACL) deficient knee, excellent outcomes are achieved in many patients with an isolated, intra-articular ACL reconstruction. Some patients, however, have ongoing instability or suffer graft rupture. Failure after ACL reconstruction is multifactorial, but residual anterolateral rotatory laxity is 1 potential contributing factor. Read More

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December 2018

Clinical Outcomes After Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction.

Tech Orthop 2018 Dec 25;33(4):225-231. Epub 2017 Dec 25.

Centre Orthopédique Santy, FIFA Medical Centre of Excellence, Groupe Ramsay-Générale de Santé, Hôpital Privé Jean Mermoz, Lyon, France.

Background: Graft rupture rate, return to sport and persistent rotational instability remain a concern postoperatively following anterior cruciate ligament (ACL) reconstruction. The anterolateral ligament (ALL) has recently been shown to act as a lateral knee stabilizer that helps improve rotational stability. To improve functional and clinical outcomes, a combined ACL reconstruction with an associated ALL reconstruction has been proposed. Read More

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December 2018