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    28586 results match your criteria Graft Versus Host Disease

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    Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4.
    Transpl Infect Dis 2017 Jul 19. Epub 2017 Jul 19.
    Department of Pharmacy, Radboud University Nijmegen Medical Centre and Centre of Expertise in Mycology Radboud UMC/CWZ, Nijmegen, The Netherlands.
    Patients undergoing treatment with immunosuppressant drugs following solid organ or hematopoietic stem cell transplantation are at particular risk for development of serious infections such as invasive aspergillosis. Four triazole antifungal drugs, voriconazole, posaconazole, itraconazole, and isavuconazole, are approved to treat invasive aspergillosis either as first- or second-line therapy. All of these agents are inhibitors of cytochrome P450 3A4, which plays a key role in metabolizing immunosuppressant drugs such as cyclosporine, tacrolimus, and sirolimus. Read More

    Treg-protected donor lymphocyte infusions: a new tool to address the graft-versus-leukemia effect in the absence of graft-versus-host disease in patients relapsed after HSCT.
    Int J Hematol 2017 Jul 18. Epub 2017 Jul 18.
    Department of Hematology, Transfusion Medicine and Biotechnologies, Ospedale Civile, Pescara, Italy.
    In high-risk acute leukemia patients undergoing haploidentical hematopoietic stem cell transplantation (HSCT), adoptive immunotherapy with T regulatory cells (Tregs) and T conventional cells (Tcons) prevented acute and chronic graft-versus-host disease (GvHD), favored post-transplant immunological reconstitution and was associated with a powerful graft-versus-leukemia (GvL) effect. With a particularly innovative approach, we developed a treatment with a Treg-protected donor lymphocyte infusion (DLI) for patients with early relapse after HSCT and we report here the results obtained in the first patient with APL (M3v) relapsed after a second matched allogeneic HSCT (15% blasts and 75% of donor cells in bone marrow). The patient received a first infusion of 2. Read More

    Potential for Monitoring Gut Microbiota for Diagnosing Infections and Graft-versus-Host Disease in Cancer and Stem Cell Transplant Patients.
    Clin Chem 2017 Jul 18. Epub 2017 Jul 18.
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX;
    Background: Gut microbiota, the collective community of microorganisms inhabiting the intestine, have been shown to provide many beneficial functions for the host. Recent advances in next-generation sequencing and advanced molecular biology approaches have allowed researchers to identify gut microbiota signatures associated with disease processes and, in some cases, establish causality and elucidate underlying mechanisms.

    Content: This report reviews 3 commonly used methods for studying the gut microbiota and microbiome (the collective genomes of the gut microorganisms): 16S rRNA gene sequencing, bacterial group or species-specific quantitative polymerase chain reaction (qPCR), and metagenomic shotgun sequencing (MSS). Read More

    The Role of Low-dose Anti-thymocyte Globulin as Standard Prophylaxis in Mismatched and Matched Unrelated Hematopoietic Peripheral Stem Cell Transplantation for Hematologic Malignancies.
    Clin Lymphoma Myeloma Leuk 2017 Jun 29. Epub 2017 Jun 29.
    Hematology Department, BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.
    Introduction: Anti-thymocyte globulin (ATG)-based immunosuppressive therapy is often used in allogeneic hematopoietic cell transplantation to reduce incidence and severity of graft-versus-host disease (GVHD).

    Patients And Methods: In our observational study, ATG (rabbit, Thymoglobulin; Sanofi, 5 mg/kg) was administered as a standardized part of the conditioning in 97 patients with a median age of 34 years (range, 14-58 years), allotransplanted for hematologic malignancies from matched (8/8; n = 52) and allele or antigen mismatched (7/8; n = 43 and 6/8; n = 2) unrelated donors.

    Results: Five-year overall survival (OS) was 46. Read More

    Respiratory Virus prior to Hematopoietic Cell Transplantation is associated with allo-immune mediated lung syndromes.
    J Allergy Clin Immunol 2017 Jul 14. Epub 2017 Jul 14.
    Blood and Marrow Transplantation Program, Department of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands; U-DANCE Laboratory of Translational Immunology, University Medical Center Utrecht, The Netherlands.
    Background: Allo-immune mediated lung syndromes (allo-LS) are life-threatening complications after hematopoietic cell transplantation (HCT). Respiratory virus (RV) has been suggested to play a role in the pathogenesis.

    Objective: We studied the relation between RV-DNA/RNA detection in upper/lower airway before HCT and the occurrence of allo-LS. Read More

    Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model.
    Front Immunol 2017 30;8:756. Epub 2017 Jun 30.
    Sorbonne Universités, UPMC Université Paris 06, CIMI-PARIS (Centre d'Immunologie et des Maladies Infectieuses), INSERM U 1135, CNRS ERL 8255, Paris, France.
    Background: Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. Previous studies using a mouse model of GVHD have shown that targeting the T-cell Inducible COStimulator (ICOS, CD278) molecule is beneficial, but it is unclear whether the same applies to human cells. Read More

    Donor Lymphocyte Infusions Used to Treat Mixed Chimeric and High-Risk Patient Populations in the Relapsed and Non-Relapsed Settings after Allogeneic Transplant for Hematologic Malignancies are Associated with High 5-Year Survival if Persistent Full Donor Chimerism is Obtained or Maintained.
    Biol Blood Marrow Transplant 2017 Jul 13. Epub 2017 Jul 13.
    Indiana Blood and Marrow Transplantation, Franciscan Health, 8111 South Emerson Avenue, Suite 207, Indianapolis, IN 46237.
    Mixed chimerism (MC), a persistent or increasing number of host cells after allogeneic hematopoietic stem cell transplant (HSCT), is a predictor of disease relapse. Donor lymphocyte infusions (DLI) have the potential to enhance the graft vs. malignancy (GvM) effect, reducing the risk of relapse in patients with MC. Read More

    Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Jul 16. Epub 2017 Jul 16.
    Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations. Read More

    Allogeneic Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide as Graft-Versus-Host Disease Prophylaxis in Multiple Myeloma.
    Biol Blood Marrow Transplant 2017 Jul 12. Epub 2017 Jul 12.
    Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
    Allogeneic blood or marrow transplantation (alloBMT) may lead to long-term disease control in patients with multiple myeloma (MM). However, historically, the use of alloBMT in MM has been limited by its high non-relapse mortality (NRM) rates primarily from graft versus host disease (GVHD). We previously demonstrated that post-transplantation cyclophosphamide (PTCy) decreases the toxicities of both acute and chronic GVHD rates following alloBMT. Read More

    Surgical treatment of intestinal complications of graft versus host disease in the pediatric population: Case series and review of literature.
    J Pediatr Surg 2017 Jun 28. Epub 2017 Jun 28.
    Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY; Department of Pediatric Surgery, Women and Children's Hospital of Buffalo, Buffalo, NY. Electronic address:
    Background/purpose: Intestinal complications of acute graft-versus-host disease (aGVHD) include hemorrhage and perforation in the short-term, and stricture with bowel obstruction in the long-term. As medical management of severe aGVHD has improved, more patients are surviving even advanced stages of intestinal aGVHD. This review summarizes the available pediatric literature on surgical treatment of complications of intestinal GVHD. Read More

    Dynamics of Torque Teno virus plasma DNAemia in allogeneic stem cell transplant recipients.
    J Clin Virol 2017 Jul 8;94:22-28. Epub 2017 Jul 8.
    Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain. Electronic address:
    Background: Torque Teno virus (TTV) plasma DNA load directly correlate with the level of immunosuppresion in different clinical settings. It is uncertain whether this may be the case in allogeneic hematopoietic stem cell transplant recipients (allo-HSCT).

    Objectives: We characterized the dynamics of TTV DNAemia in patients undergoing T-cell replete allo-SCT. Read More

    Clinical-associated characteristics and microbiological features of bloodstream nontyphoidal salmonella infection in adult patients receiving allogeneic hematopoietic stem cell transplantation.
    Ann Hematol 2017 Jul 15. Epub 2017 Jul 15.
    Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
    Bloodstream nontyphoidal salmonella (NTS) infection is rare, but its associated characteristics and microbiological features in immunocompromised patients are worth paying attention to, particularly for those receiving allogeneic hematopoietic stem cell transplantation (SCT). No studies so far have analyzed post-transplant bloodstream NTS infection. Therefore, we reviewed 423 adult patients undergoing allogeneic hematopoietic SCT from 2003 to 2014. Read More

    What compatibility in 2017 for the haematopoietic stem cell transplantation?
    Transfus Clin Biol 2017 Jul 11. Epub 2017 Jul 11.
    EFS Aquitaine Limousin, unité Inserm 1035, équipe cellules souches hématopoïétiques normales et leucémiques, place Amélie-Raba-Léon, CS 21010, 33075 Bordeaux cedex, France. Electronic address:
    The diversification of potential donors to perform stem cell allografts now enables to propose a compatible graft cell source adapted to the different clinical situations. Transplants with a geno-identical sibling donor, otherwise with the most HLA-compatible unrelated donor, remain the first-line solutions. Alternative transplants allow to graft patients having no donors in international registries, owing to the rarity of their HLA typing. Read More

    MRI-based evaluation of multiorgan iron overload is a predictor of adverse outcomes in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation.
    Oncotarget 2017 Jul 5. Epub 2017 Jul 5.
    Department of Radiology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
    The medical records of 44 pediatric patients who underwent allogeneic transplantation from 2011 to 2015 were retrospectively reviewed. Magnetic resonance imaging was used to measure iron concentrations in the liver, spleen, pancreas and bone. These patients were divided into two groups, 18 with non-elevated (< 100 μmol/g; Group 1) liver iron concentration before transplantation and 26 with elevated (> 100 μmol/g; Group 2) concentration . Read More

    Cytomegalovirus appendicitis after hematopoietic stem cell transplantation.
    Transpl Infect Dis 2017 Jul 14. Epub 2017 Jul 14.
    Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    We present the case of a young man with acute lymphoblastic leukemia who developed cytomegalovirus (CMV) appendicitis after receiving alemtuzumab for acute refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (HSCT). CMV appendicitis is a rare complication; and we are reporting the first case to our knowledge of CMV appendicitis following HSCT. Our case highlights the importance of recognition of CMV viral reactivation following the use of alemtuzumab. Read More

    Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor.
    Transplant Direct 2017 Jul 6;3(7):e169. Epub 2017 Jun 6.
    Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, Australia.
    The syndrome of fever and pancytopenia is not infrequently encountered postliver transplant, and a broad differential list of infectious and noninfectious aetiologies can be invoked. A transplant patient is susceptible to more than 1 opportunistic infection or disease process. We described the diagnostic conundrums in managing our patient who ran a complex protracted course postliver transplant. Read More

    Disseminated Nocardia cyriacigeorgia causing pancreatitis in a haploidentical stem cell transplant recipient.
    IDCases 2017 27;9:73-76. Epub 2017 Jun 27.
    Division of Infectious Diseases, Department of Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, 1015 Chestnut St., Suite 1020, Philadelphia, PA 19107, United States.
    We report the first published case of acute pancreatitis secondary to disseminated nocardiosis in a hematopoietic stem cell transplant (HSCT) recipient on chronic immunosuppression for graft-versus-host disease (GVHD). Nocardiosis in the HSCT population is relatively rare, and has not yet been described in haploidentical HSCT recipients. Our patient is a 28-year-old male with a history of haploidentical HSCT and GVHD of the skin and lung who was admitted to the hospital with acute pancreatitis. Read More

    Efficacy of two different doses of rabbit anti-T-lymphocyte globulin to prevent graft-versus-host disease in children with haematological malignancies transplanted from an unrelated donor: a multicentre, randomised, open-label, phase 3 trial.
    Lancet Oncol 2017 Jul 10. Epub 2017 Jul 10.
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico "San Matteo", Pavia, Italy.
    Background: Although rabbit anti-T-lymphocyte globulin (ATLG) is largely used for the prevention of immune-mediated complications in patients given allogeneic haemopoietic stem-cell transplantation (HSCT) from an unrelated donor, the optimum dose of this drug in children is still undefined. We aimed to test whether a higher dose of ATLG was superior to a lower dose for prevention of grade II-IV acute graft-versus-host disease (GVHD).

    Methods: We conducted a multicentre, randomised, open-label, phase 3 trial in seven Italian centres comparing two different doses of ATLG (30 mg/kg vs 15 mg/kg, given intravenously over 3 days, from day -4 to -2) in children (aged 0-18 years) with haematological malignancies transplanted from an unrelated donor, selected using high-resolution typing for HLA-class I/II loci. Read More

    Dynamics of Torque Teno virus viremia could predict risk of complications after allogeneic hematopoietic stem cell transplantation.
    Med Microbiol Immunol 2017 Jul 12. Epub 2017 Jul 12.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases. However, the first year post-transplantation is often complicated by infections and graft-versus-host disease (GVHD). Improvements in immunological monitoring could reduce such post-transplant complications. Read More

    BK Virus-associated Hemorrhagic Cystitis in Patients with Allogeneic Hematopoietic Cell Transplantation: Report of Three Cases.
    Hematol Rep 2017 Jun 26;9(2):7205. Epub 2017 Jun 26.
    Infectious Diseases and Clinical Microbiology Clinic, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
    BK viras is a human polyoma viras. It is acquired in early childhood and remains life-long latent in the genitourinary system. BK virus replication is more common in receiving immunosuppressive therapy receiving patients and transplant patients. Read More

    Early and Late Complications in Patients with Allogeneic Transplantation of Hematopoietic Stem Cell - Case Report.
    Open Access Maced J Med Sci 2017 Jun 9;5(3):340-343. Epub 2017 May 9.
    GOB "8-mi Septemvri" Skopje, Skopje, Republic of Macedonia.
    Background: Allogeneic hematopoietic stem cells transplantation (HSCT) is a curative intervention in patients with haematological malignant and non-malignant diseases, immunodeficiency, autoimmune, and other genetic diseases. Early complications are complications that are occurring in the first 100 days, while complications arising after the 100th day of transplantation belong to late complications.

    Case Report: Forty-nine years old patient with AML treated with allogeneic HSCT from HLA-identical (sister) donor. Read More

    Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40.
    Mol Ther 2017 Jul 8. Epub 2017 Jul 8.
    Bellicum Pharmaceuticals, Houston, TX 77030, USA. Electronic address:
    Anti-tumor efficacy of T cells engineered to express chimeric antigen receptors (CARs) is dependent on their specificity, survival, and in vivo expansion following adoptive transfer. Toll-like receptor (TLR) and CD40 signaling in T cells can improve persistence and drive proliferation of antigen-specific CD4(+) and CD8(+) T cells following pathogen challenge or in graft-versus-host disease (GvHD) settings, suggesting that these costimulatory pathways may be co-opted to improve CAR-T cell persistence and function. Here, we present a novel strategy to activate TLR and CD40 signaling in human T cells using inducible MyD88/CD40 (iMC), which can be triggered in vivo via the synthetic dimerizing ligand, rimiducid, to provide potent costimulation to CAR-modified T cells. Read More

    STAT3 Expression in Host Myeloid Cells Controls GVHD Severity.
    Biol Blood Marrow Transplant 2017 Jul 7. Epub 2017 Jul 7.
    Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA. Electronic address:
    Professional antigen presenting cell (APCs) are important modulators of acute graft-versus-host disease (GVHD). Although dendritic cells (DCs) are most potent APC subset, other myeloid cells, especially macrophages (MFs) and neutrophils have recently been shown to play a role in the severity of GVHD. However, the critical molecular mechanisms that determine the functions of myeloid cells in GVHD are unclear. Read More

    Reduced BUCY 2 and G-CSF-primed bone marrow associates with low graft-versus-host-disease and transplant-related mortality in allogeneic HSCT.
    Ann Hematol 2017 Jul 9. Epub 2017 Jul 9.
    Internal Medicine Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
    Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the ideal treatment for several diseases. However, the morbidity and mortality associated with the procedure might limit its widespread use; therefore, we implemented reduced BUCY2 as conditioning method along with the use of G-CSF-primed bone marrow (G-BM) in order to reduce complications, including graft-versus-host-disease (GVHD), and to improve survival in these patients. An analysis of transplant characteristics, complications, and survival of patients undergoing an allo-HSCT using this conditioning regimen (busulfan 12 mg/kg and cyclophosphamide 80 mg/kg) plus G-BM was performed. Read More

    Serum Vitamin A Levels May Affect the Severity of Ocular Graft-versus-Host Disease.
    Front Med (Lausanne) 2017 22;4:67. Epub 2017 Jun 22.
    Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
    Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established therapeutic option for a range of inherited and acquired hematological disorders. However, graft-versus-host disease (GVHD) remains the leading cause of non-relapse mortality in allogeneic HSCT recipients. Ocular involvement occurs in up to 80% of chronic GVHD patients. Read More

    Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4(+) Foxp3(+) Regulatory T Cells.
    Front Immunol 2017 23;8:721. Epub 2017 Jun 23.
    Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
    Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of donor CD4(+) conventional (CD4(+)CD25(-)Foxp3(-), Tconv) and regulatory (CD4(+)CD25(+)Foxp3(+), Treg) T cells in aGvHD using tamoxifen-inducible CD28 knockout (iCD28KO) or wild-type (wt) littermates as donors of CD4(+) Tconv and Treg. In the highly inflammatory C57BL/6 into BALB/c allo-HSCT transplantation model, CD28 depletion on donor CD4(+) Tconv reduced clinical signs of aGvHD, but did not significantly prolong survival of the recipient mice. Read More

    Pulmonary endothelial chimerism after hematopoietic stem cell transplantation.
    Surg Today 2017 Jul 8. Epub 2017 Jul 8.
    Department of Thoracic Surgery, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
    Purpose: Few studies have investigated pulmonary endothelial chimerism after hematopoietic stem cell transplantation. In the present study, we investigated pulmonary endothelial chimerism using the ABH histo-blood group antigen as an identifying marker in cases of ABO-incompatible hematopoietic stem cell transplantation.

    Methods: Sixteen lung samples were analyzed. Read More

    Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes.
    Curr Res Transl Med 2017 Jul 5. Epub 2017 Jul 5.
    Department of Hematology, CHRU de Lille, 59037 Lille, France. Electronic address:
    Antifungal prophylaxis (AP) has dramatically changed the epidemiology of invasive aspergillosis (IA). To better understand the differences in terms of clinical significance of IA between allogeneic stem cell transplantation (allo-SCT) recipients and patients treated for leukemia, we report a single-center study of 735 unselected consecutive patients treated between 2000 and 2004, before the era of systematic AP. Probable or confirmed IA were observed in 29 patients (2008 EORTC/MSG criteria), including 7/235 undergoing allo-SCT (5. Read More

    Liver Biopsy Findings in Patients with Hematopoietic-cell Transplantation.
    Hum Pathol 2017 Jul 5. Epub 2017 Jul 5.
    Department of Pathology, Medical College of Wisconsin, Milwaukee. Electronic address:
    Liver dysfunction is a frequent complication after hematopoietic-cell transplantation (HCT). Liver biopsy has an important role for confirming the diagnosis of graft versus host disease (GVHD) or other liver diseases. The histological features of GVHD are not specific, and GVHD and other coexisting diseases may be present in the same biopsy, which makes the histologic interpretation of the liver biopsy more complex and challenging. Read More

    B Lymphocyte Chemoattractant (CXCL13) Is an Indicator of Acute Gastrointestinal GVHD in Murine Model.
    Inflammation 2017 Jul 7. Epub 2017 Jul 7.
    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou, Zhejiang, 325002, China.
    Gastrointestinal acute graft-vs.-host disease (GI aGVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation and is a major cause of morbidity and mortality. In addition, GI aGVHD is often clinically indistinguishable from other causes of GI dysfunction such as conditioning regimen toxicity, infections, or medications, which complicates the diagnosis. Read More

    Associations between acute GVHD-related biomarkers and endothelial cell activation after allogeneic hematopoietic stem cell transplantation.
    Transpl Immunol 2017 Jul 5. Epub 2017 Jul 5.
    Kansai Medical University, Japan.
    Background: Hematopoietic stem cell transplantation (HSCT) can cause serious transplant-related complications such as graft-versus-host disease (GVHD). Acute GVHD (aGVHD) has been diagnosed by clinical manifestations, laboratory data and pathological effects until now, but recently the discovery of specific biomarkers such as suppression of tumorigenicity 2 (ST2), elafin and regenerating islet-derived 3α (REG3α) is challenging this approach.

    Methods: We investigated the expression of aGVHD-related markers (regulated on activation normal T-cell expressed and secretes: RANTES, elafin, REG3α and ST2) and endothelial cell activation markers (soluble vascular cell adhesion molecule: sVCAM-1 and plasminogen activator inhibitor: PAI-1) in patients undergoing allogeneic HSCT. Read More

    Integrated meta-omic analyses of the gastrointestinal tract microbiome in patients undergoing allogeneic hematopoietic stem cell transplantation.
    Transl Res 2017 Jun 20. Epub 2017 Jun 20.
    Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Saarland University Medical Center, Klinik für Innere Medizin II, Homburg, Germany. Electronic address:
    In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), treatment-induced changes to the gastrointestinal tract (GIT) microbiome have been linked to adverse outcomes, most notably graft-versus-host disease (GvHD). However, it is presently unknown whether this relationship is causal or consequential. Here, we performed an integrated meta-omic analysis to probe deeper into the GIT microbiome changes during allo-HSCT and its accompanying treatments. Read More

    Pseudo-autologous stem cell transplantation for donor-derived mantle cell lymphoma 12 years after allogeneic transplantation.
    Int J Hematol 2017 Jul 6. Epub 2017 Jul 6.
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho Omiya-ku, Saitama, 330-8503, Japan.
    Donor-derived malignancy is a rare morbidity after allogeneic hematopoietic stem cell transplantation (HSCT), in which most previous cases have presented as acute leukemia or myelodysplastic syndrome. There have, however, been very few reports of donor-derived lymphoma. Here, we present a case of donor-derived mantle cell lymphoma 12 years after allogeneic HSCT, which was successfully treated with chemotherapy followed by pseudo-autologous HSCT (pASCT), i. Read More

    Sickle Cell Anemia and Comorbid Leg Ulcer Treated With Curative Peripheral Blood Stem Cell Transplantation.
    Int J Low Extrem Wounds 2017 Mar 9;16(1):56-59. Epub 2017 Jan 9.
    4 National Heart, Lung, and Blood Institute and National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda MD, USA.
    Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease. Read More

    TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease.
    Immune Netw 2017 Jun 20;17(3):144-151. Epub 2017 Jun 20.
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
    Graft-versus-host disease (GHVD) is a severe complication after allogeneic hematopoietic stem cell transplantation. The degree of inflammation in the gastrointestinal tract, a major GVHD target organ, correlates with the disease severity. Intestinal inflammation is initiated by epithelial damage caused by pre-conditioning irradiation. Read More

    In vitro effects of different 8-methoxypsoralen treatment protocols for extracorporeal photopheresis on mononuclear cells.
    Cent Eur J Immunol 2017 8;42(1):1-9. Epub 2017 May 8.
    University Medical Center Göttingen, Göttingen, Germany.
    Extracorporeal photopheresis (ECP) is an important second-line therapy for graft-versus-host disease. A central therapeutic mechanism is the induction of immune tolerance through apoptosis in patient's leukocytes, caused by ex vivo incubation with 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation. We hypothesized that different 8-MOP incubation times and an additional 8-MOP removal step could influence the apoptosis kinetics of leukocytes in general and in particular could lead to different apoptotic levels in the leukocyte subpopulations. Read More

    Myelodysplastic syndrome with myelofibrosis in which azacitidine therapy was effective and cord blood transplantation was carried out.
    Rinsho Ketsueki 2017 ;58(6):601-606
    Department of Clinical Oncology and Hematology, The Jikei University Hospital.
    Myelodysplastic syndrome with myelofibrosis (MDS-F) is a disease with a poor prognosis, and patients with this condition are at an increased risk of engraftment failures after allogeneic hematopoietic stem cell transplantation (SCT). Azacitidine (AZA) is effective in high-risk MDS patients. However, the effects of AZA on MDS-F have not been elucidated. Read More

    CIK as therapeutic agents against tumors.
    J Autoimmun 2017 Jul 2. Epub 2017 Jul 2.
    USS Centro di Terapia Cellulare "G. Lanzani", USC Ematologia, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:
    Cytokine Induced Killer (CIK) cells are ex vivo expanded and activated T lymphocytes obtained by sequential incubation of Peripheral Blood Mononuclear cells (PBMNC) with Interferon γ (IFNG), anti CD3 monoclonal antibody OKT3 and IL2. These cells, while retaining few characteristics of the Effector memory T cells subpopulation, acquired during culture CD56 expression, as well as non specific, Natural Killer like, anti tumoral cytotoxicity. CIK cells from human are equivalent to expanded NKT cells in mouse. Read More

    Partial T-cell depletion improves the composite endpoint graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic stem cell transplantation.
    Leuk Lymphoma 2017 Jul 6:1-11. Epub 2017 Jul 6.
    a Department of Oncology, Division of Hematology , Geneva University Hospitals , Geneva , Switzerland.
    Graft-versus-host disease (GvHD)-free, relapse-free survival (GRFS) is a recently reported composite endpoint that allows to simultaneously estimate risk of death, relapse and GvHD after allogeneic hematopoietic stem cell transplantation (HSCT). In this retrospective study comprising 333 patients transplanted for hematologic malignancies, we compared GRFS in patients receiving partial T-cell-depleted (pTCD) grafts with patients receiving T-cell-replete grafts (No-TCD). pTCD was associated with a significantly improved GRFS. Read More

    The emerging role of immune checkpoint based approaches in AML and MDS.
    Leuk Lymphoma 2017 Jul 6:1-13. Epub 2017 Jul 6.
    a Department of Leukemia , The University of Texas M. D. Anderson Cancer Center , Houston , TX , USA.
    The development of immune checkpoint inhibitors represents a major breakthrough in the field of cancer therapeutics. Pursuant to their success in melanoma and numerous solid tumor malignancies, these agents are being investigated in hematological malignancies including acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Although AML/MDS have traditionally been considered to be less immunogenic than solid tumor malignancies, recent pre-clinical models suggest a therapeutic role for immune checkpoint inhibition in these diseases. Read More

    Children Receiving Hematopoietic Stem Cell Transplantation are at Increased Risk of Onychocryptosis Requiring Surgical Management.
    J Pediatr Hematol Oncol 2017 Jul 3. Epub 2017 Jul 3.
    *Department of Surgery †Division of Pediatric Hematology and Oncology, Duke University Medical Center, Durham, NC.
    Purpose: At our institution, a high proportion of children with onychocryptosis (ingrown toenail) requiring surgical intervention were noted to have a history of hematopoietic stem cell transplantation (HSCT). We analyzed the characteristics of patients who underwent surgical intervention for onychocryptosis and examined our institutional HSCT database to determine if an association exists between onychocryptosis and HSCT.

    Materials And Methods: Surgical cases for onychocryptosis performed from 2000 to 2012 were identified. Read More

    Superior GVHD-free, relapse-free survival for G-BM to G-PBSC grafts is associated with higher MDSCs content in allografting for patients with acute leukemia.
    J Hematol Oncol 2017 Jul 4;10(1):135. Epub 2017 Jul 4.
    Department of Hematology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
    Background: Granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood stem cells (G-PBSC) has largely replaced unstimulated bone marrow (un-BM) for allografting because of accelerated engraftment, but with a higher morbidity and mortality of graft-versus-host-disease (GVHD). Recent studies suggested that G-CSF-primed BM (G-BM) had similar engraftment but lower morbidity and mortality of GVHD comparing to G-PBSC. A prospective, randomized, multicenter study was conducted to compare G-BM with G-PBSC as the grafts in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute leukemia in first complete remission (CR1). Read More

    Outcomes of allogeneic stem cell transplantation in patients with paroxysmal nocturnal hemoglobinuria with or without aplastic anemia.
    Eur J Haematol 2017 Jul 4. Epub 2017 Jul 4.
    Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Objective: The aim of this study was to evaluate the long-term outcomes of allogeneic stem cell transplantation (SCT) in patients with paroxysmal nocturnal hemoglobinuria (PNH) with or without aplastic anemia (AA).

    Method: A total of 33 patients with PNH clones who underwent allogeneic SCT were analyzed.

    Results: After a median follow-up of 57 months (range, 6. Read More

    Psoriasiform graft-versus-host disease distributed along Blaschko's lines.
    J Cutan Pathol 2017 Jul 4. Epub 2017 Jul 4.
    Department of Internal Medicine, Division of Dermatology, Ohio State University Wexner Medical Center.
    The skin is one of the most frequently affected organs in chronic graft-versus-host disease (cGVHD). Cutaneous involvement of cGVHD presents varied features from lichenoid to sclerodermiform changes that some clinicians may find difficult to accurately diagnose, particularly when the cGVHD mimics other disease processes. Read More

    Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease.
    Front Immunol 2017 19;8:717. Epub 2017 Jun 19.
    Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden.
    Chronic graft-versus-host disease (cGVHD) is a debilitating complication arising in around half of all patients treated with an allogeneic hematopoietic stem cell transplantation. Even though treatment of severe cGVHD has improved during recent years, it remains one of the main causes of morbidity and mortality in affected patients. Biomarkers in blood that could aid in the diagnosis and classification of cGVHD severity are needed for the development of novel treatment strategies that can alleviate symptoms and reduce the need for painful and sometimes complicated tissue biopsies. Read More

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